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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TFEB-CADM2 (FusionGDB2 ID:90322)

Fusion Gene Summary for TFEB-CADM2

check button Fusion gene summary
Fusion gene informationFusion gene name: TFEB-CADM2
Fusion gene ID: 90322
HgeneTgene
Gene symbol

TFEB

CADM2

Gene ID

7942

253559

Gene nametranscription factor EBcell adhesion molecule 2
SynonymsALPHATFEB|BHLHE35|TCFEBIGSF4D|NECL3|Necl-3|SynCAM 2|synCAM2
Cytomap

6p21.1

3p12.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor EBT-cell transcription factor EBclass E basic helix-loop-helix protein 35cell adhesion molecule 2immunoglobulin superfamily member 4Dnectin-like 3nectin-like protein 3synaptic cell adhesion molecule 2
Modification date2020032920200322
UniProtAcc.

Q8N3J6

Ensembl transtripts involved in fusion geneENST00000230323, ENST00000358871, 
ENST00000373033, ENST00000403298, 
ENST00000420312, ENST00000394283, 
ENST00000485126, ENST00000383699, 
ENST00000405615, ENST00000407528, 
Fusion gene scores* DoF score12 X 11 X 8=105615 X 13 X 8=1560
# samples 1417
** MAII scorelog2(14/1056*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1560*10)=-3.19793937761191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TFEB [Title/Abstract] AND CADM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTFEB(41653828)-CADM2(85851197), # samples:1
Anticipated loss of major functional domain due to fusion event.TFEB-CADM2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TFEB-CADM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TFEB-CADM2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TFEB-CADM2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TFEB-CADM2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTFEB

GO:0010468

regulation of gene expression

27278822

HgeneTFEB

GO:0045893

positive regulation of transcription, DNA-templated

27278822|29146937

HgeneTFEB

GO:0045944

positive regulation of transcription by RNA polymerase II

19556463


check buttonFusion gene breakpoints across TFEB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CADM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-B9-A69E-01ATFEBchr6

41653828

-CADM2chr3

85851197

+


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Fusion Gene ORF analysis for TFEB-CADM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000230323ENST00000485126TFEBchr6

41653828

-CADM2chr3

85851197

+
5CDS-intronENST00000358871ENST00000485126TFEBchr6

41653828

-CADM2chr3

85851197

+
5CDS-intronENST00000373033ENST00000485126TFEBchr6

41653828

-CADM2chr3

85851197

+
5CDS-intronENST00000403298ENST00000485126TFEBchr6

41653828

-CADM2chr3

85851197

+
5CDS-intronENST00000420312ENST00000485126TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000230323ENST00000383699TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000230323ENST00000405615TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000230323ENST00000407528TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000358871ENST00000383699TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000358871ENST00000405615TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000358871ENST00000407528TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000403298ENST00000383699TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000403298ENST00000405615TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000403298ENST00000407528TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000420312ENST00000383699TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000420312ENST00000405615TFEBchr6

41653828

-CADM2chr3

85851197

+
Frame-shiftENST00000420312ENST00000407528TFEBchr6

41653828

-CADM2chr3

85851197

+
In-frameENST00000373033ENST00000383699TFEBchr6

41653828

-CADM2chr3

85851197

+
In-frameENST00000373033ENST00000405615TFEBchr6

41653828

-CADM2chr3

85851197

+
In-frameENST00000373033ENST00000407528TFEBchr6

41653828

-CADM2chr3

85851197

+
intron-3CDSENST00000394283ENST00000383699TFEBchr6

41653828

-CADM2chr3

85851197

+
intron-3CDSENST00000394283ENST00000405615TFEBchr6

41653828

-CADM2chr3

85851197

+
intron-3CDSENST00000394283ENST00000407528TFEBchr6

41653828

-CADM2chr3

85851197

+
intron-intronENST00000394283ENST00000485126TFEBchr6

41653828

-CADM2chr3

85851197

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373033TFEBchr641653828-ENST00000383699CADM2chr385851197+10005123210932358421
ENST00000373033TFEBchr641653828-ENST00000407528CADM2chr385851197+2531123210932478461
ENST00000373033TFEBchr641653828-ENST00000405615CADM2chr385851197+2479123210932478462

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373033ENST00000383699TFEBchr641653828-CADM2chr385851197+0.0001477020.9998523
ENST00000373033ENST00000407528TFEBchr641653828-CADM2chr385851197+0.0033376190.9966624
ENST00000373033ENST00000405615TFEBchr641653828-CADM2chr385851197+0.0032463410.99675363

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Fusion Genomic Features for TFEB-CADM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TFEBchr641653827-CADM2chr385851196+0.0004857240.9995142
TFEBchr641653827-CADM2chr385851196+0.0004857240.9995142

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TFEB-CADM2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:41653828/chr3:85851197)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CADM2

Q8N3J6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. {ECO:0000269|PubMed:17967169}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFEBchr6:41653828chr3:85851197ENST00000230323-91010_44317477.0Compositional biasNote=Gln-rich
HgeneTFEBchr6:41653828chr3:85851197ENST00000230323-91035_44317477.0Compositional biasNote=Poly-Gln
HgeneTFEBchr6:41653828chr3:85851197ENST00000373033-8910_44317477.0Compositional biasNote=Gln-rich
HgeneTFEBchr6:41653828chr3:85851197ENST00000373033-8935_44317477.0Compositional biasNote=Poly-Gln
HgeneTFEBchr6:41653828chr3:85851197ENST00000403298-8910_44317477.0Compositional biasNote=Gln-rich
HgeneTFEBchr6:41653828chr3:85851197ENST00000403298-8935_44317477.0Compositional biasNote=Poly-Gln
HgeneTFEBchr6:41653828chr3:85851197ENST00000420312-8910_44232392.0Compositional biasNote=Gln-rich
HgeneTFEBchr6:41653828chr3:85851197ENST00000420312-8935_44232392.0Compositional biasNote=Poly-Gln
HgeneTFEBchr6:41653828chr3:85851197ENST00000230323-910235_288317477.0DomainbHLH
HgeneTFEBchr6:41653828chr3:85851197ENST00000373033-89235_288317477.0DomainbHLH
HgeneTFEBchr6:41653828chr3:85851197ENST00000403298-89235_288317477.0DomainbHLH
HgeneTFEBchr6:41653828chr3:85851197ENST00000230323-910136_153317477.0MotifNuclear export signal
HgeneTFEBchr6:41653828chr3:85851197ENST00000373033-89136_153317477.0MotifNuclear export signal
HgeneTFEBchr6:41653828chr3:85851197ENST00000403298-89136_153317477.0MotifNuclear export signal
HgeneTFEBchr6:41653828chr3:85851197ENST00000420312-89136_153232392.0MotifNuclear export signal
HgeneTFEBchr6:41653828chr3:85851197ENST00000230323-910156_165317477.0RegionStrong transcription activation domain
HgeneTFEBchr6:41653828chr3:85851197ENST00000230323-910298_319317477.0RegionNote=Leucine-zipper
HgeneTFEBchr6:41653828chr3:85851197ENST00000373033-89156_165317477.0RegionStrong transcription activation domain
HgeneTFEBchr6:41653828chr3:85851197ENST00000373033-89298_319317477.0RegionNote=Leucine-zipper
HgeneTFEBchr6:41653828chr3:85851197ENST00000403298-89156_165317477.0RegionStrong transcription activation domain
HgeneTFEBchr6:41653828chr3:85851197ENST00000403298-89298_319317477.0RegionNote=Leucine-zipper
HgeneTFEBchr6:41653828chr3:85851197ENST00000420312-89156_165232392.0RegionStrong transcription activation domain
TgeneCADM2chr6:41653828chr3:85851197ENST00000383699110319_35029405.0Compositional biasNote=Thr-rich
TgeneCADM2chr6:41653828chr3:85851197ENST00000405615010319_35022438.0Compositional biasNote=Thr-rich
TgeneCADM2chr6:41653828chr3:85851197ENST00000407528010319_35020436.0Compositional biasNote=Thr-rich
TgeneCADM2chr6:41653828chr3:85851197ENST00000383699110127_21929405.0DomainNote=Ig-like C2-type 1
TgeneCADM2chr6:41653828chr3:85851197ENST00000383699110227_31229405.0DomainNote=Ig-like C2-type 2
TgeneCADM2chr6:41653828chr3:85851197ENST0000038369911027_11929405.0DomainNote=Ig-like V-type
TgeneCADM2chr6:41653828chr3:85851197ENST00000405615010127_21922438.0DomainNote=Ig-like C2-type 1
TgeneCADM2chr6:41653828chr3:85851197ENST00000405615010227_31222438.0DomainNote=Ig-like C2-type 2
TgeneCADM2chr6:41653828chr3:85851197ENST0000040561501027_11922438.0DomainNote=Ig-like V-type
TgeneCADM2chr6:41653828chr3:85851197ENST00000407528010127_21920436.0DomainNote=Ig-like C2-type 1
TgeneCADM2chr6:41653828chr3:85851197ENST00000407528010227_31220436.0DomainNote=Ig-like C2-type 2
TgeneCADM2chr6:41653828chr3:85851197ENST0000040752801027_11920436.0DomainNote=Ig-like V-type
TgeneCADM2chr6:41653828chr3:85851197ENST00000383699110389_43529405.0Topological domainCytoplasmic
TgeneCADM2chr6:41653828chr3:85851197ENST0000040561501025_36722438.0Topological domainExtracellular
TgeneCADM2chr6:41653828chr3:85851197ENST00000405615010389_43522438.0Topological domainCytoplasmic
TgeneCADM2chr6:41653828chr3:85851197ENST0000040752801025_36720436.0Topological domainExtracellular
TgeneCADM2chr6:41653828chr3:85851197ENST00000407528010389_43520436.0Topological domainCytoplasmic
TgeneCADM2chr6:41653828chr3:85851197ENST00000383699110368_38829405.0TransmembraneHelical
TgeneCADM2chr6:41653828chr3:85851197ENST00000405615010368_38822438.0TransmembraneHelical
TgeneCADM2chr6:41653828chr3:85851197ENST00000407528010368_38820436.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTFEBchr6:41653828chr3:85851197ENST00000230323-910366_414317477.0Compositional biasNote=Pro-rich
HgeneTFEBchr6:41653828chr3:85851197ENST00000373033-89366_414317477.0Compositional biasNote=Pro-rich
HgeneTFEBchr6:41653828chr3:85851197ENST00000403298-89366_414317477.0Compositional biasNote=Pro-rich
HgeneTFEBchr6:41653828chr3:85851197ENST00000420312-89366_414232392.0Compositional biasNote=Pro-rich
HgeneTFEBchr6:41653828chr3:85851197ENST00000420312-89235_288232392.0DomainbHLH
HgeneTFEBchr6:41653828chr3:85851197ENST00000420312-89298_319232392.0RegionNote=Leucine-zipper
TgeneCADM2chr6:41653828chr3:85851197ENST0000038369911025_36729405.0Topological domainExtracellular


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Fusion Gene Sequence for TFEB-CADM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90322_90322_1_TFEB-CADM2_TFEB_chr6_41653828_ENST00000373033_CADM2_chr3_85851197_ENST00000383699_length(transcript)=10005nt_BP=1232nt
GTGGAGTGACAGCCGGAGCCCGGGCGCCGGGCGCGGGGCTCGGTGACAGCGGAGGCGGCGGCCCGGGCGGGACGCAGGGAGCGGCCGCGG
CGCCGACGGCGGCGGGAAGGGCGGACGGGGCGGGCCTCCCTGGTGGCACGGGGCCGGAGCAGGCCGGGAGCAGGTGGCGGGCACAGCTTG
CGGGCCAGGCACCCGAACTTGCGACAAGTTGCCGGAGCCGCGGGGCGCGGGCGGCGGACAGATTGACCTTCAGAGCGAGGGAGCCAGCGC
CGGCAGCCACCATGGCGTCACGCATAGGGTTGCGCATGCAGCTCATGCGGGAGCAGGCGCAGCAGGAGGAGCAGCGGGAGCGCATGCAGC
AACAGGCTGTCATGCATTACATGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCTCGGAGGGCCGCCCACCCCGGCCATCAATACCCCCG
TCCACTTCCAGTCGCCACCACCTGTGCCTGGGGAGGTGTTGAAGGTGCAGTCCTACCTGGAGAATCCCACATCCTACCATCTGCAGCAGT
CGCAGCATCAGAAGGTGCGGGAGTACCTGTCCGAGACCTATGGGAACAAGTTTGCTGCCCACATCAGCCCAGCCCAGGGCTCTCCGAAAC
CCCCACCAGCCGCCTCCCCAGGGGTGCGAGCTGGACACGTGCTGTCCTCCTCCGCTGGCAACAGTGCTCCCAATAGCCCCATGGCCATGC
TGCACATTGGCTCCAACCCTGAGAGGGAGTTGGATGATGTCATTGACAACATTATGCGTCTGGACGATGTCCTTGGCTACATCAATCCTG
AAATGCAGATGCCCAACACGCTACCCCTGTCCAGCAGCCACCTGAATGTGTACAGCAGCGACCCCCAGGTCACAGCCTCCCTGGTGGGCG
TCACCAGCAGCTCCTGCCCTGCGGACCTGACCCAGAAGCGAGAGCTCACAGATGCTGAGAGCAGGGCCCTGGCCAAGGAGCGGCAGAAGA
AAGACAATCACAACTTAATTGAAAGGAGACGAAGGTTCAACATCAATGACCGCATCAAGGAGTTGGGAATGCTGATCCCCAAGGCCAATG
ACCTGGACGTGCGCTGGAACAAGGGCACCATCCTCAAGGCCTCTGTGGATTACATCCGGAGGATGCAGAAGGACCTGCAAAAGTCCAGGG
AGCTGGAGAACCACTCTCGCCGCCTGGAGATGACCAACAAGCAGCTCTGGCTCCGTATCCAGGCAGCCAAGGGCAGTTTCCACTAACACA
GAATGTAACCGTTGTTGAAGGTGGAACTGCAATTTTGACCTGCAGGGTTGATCAAAATGATAACACCTCCCTCCAGTGGTCAAATCCAGC
TCAACAGACTCTGTACTTTGACGACAAGAAAGCTTTAAGGGACAATAGGATCGAGCTGGTTCGCGCTTCCTGGCATGAATTGAGTATTAG
TGTCAGTGATGTGTCTCTCTCTGATGAAGGACAGTACACCTGTTCTTTATTTACAATGCCTGTCAAAACTTCCAAGGCATATCTCACCGT
TCTGGGTGTTCCTGAAAAGCCTCAGATTAGTGGATTCTCATCACCAGTTATGGAGGGTGACTTGATGCAGCTGACTTGCAAAACATCTGG
TAGTAAACCTGCAGCTGATATAAGATGGTTCAAAAATGACAAAGAGATTAAAGATGTAAAATATTTAAAAGAAGAGGATGCAAATCGCAA
GACATTCACTGTCAGCAGCACACTGGACTTCCGAGTGGACCGGAGTGATGATGGAGTGGCGGTCATCTGCAGAGTAGATCACGAATCCCT
CAATGCCACCCCTCAGGTAGCCATGCAGGTGCTAGAAATACACTATACACCATCAGTTAAGATTATACCATCGACTCCTTTTCCACAAGA
AGGACAGCCTTTAATTTTGACTTGTGAATCCAAAGGAAAACCACTGCCAGAACCTGTTTTGTGGACAAAGGATGGCGGAGAATTACCAGA
TCCTGACCGAATGGTTGTGAGTGGTAGGGAGCTAAACATTCTTTTCCTGAACAAAACGGATAATGGTACATATCGATGTGAAGCCACAAA
CACCATTGGCCAAAGCAGTGCGGAATATGTTCTCATTGTGCATGATCCTAATGCTTTGGCTGGCCAGAATGGCCCTGACCATGCTCTCAT
AGGAGGAATAGTGGCTGTAGTTGTATTTGTCACGCTGTGTTCTATCTTTCTGCTTGGTCGATATCTGGCAAGGCATAAAGGAACGTATTT
AACAAATGAAGCTAAAGGAGCTGAAGATGCACCAGATGCTGATACAGCCATTATCAATGCTGAAGGCAGCCAAGTCAATGCTGAAGAGAA
AAAAGAGTATTTCATTTAAGATGCAGGCCAAGATTCTGAGTTTTACTACCAGGCTGAATGCTGGAGAAAACTGGCTATCATCTTTCAGAA
GTCATTTCTACCATCGTCTGCTACCCTTATTAACTCCCATACTGTACTGCTATCAGTAGCCAGTGTATACCAACAATCAGCTGTTGAAAG
CATCATTCTTTAATTACTGTACCATCCATAATGCAGGACATTTCTTACTGCCTAAATTTCACACCATTGCTCTTTTAACATACAGTGCTT
GAATATACAGCCTTAACAATGTTAATCATCTCCTTGGATCATTATATTGAGTGGTTTTTATACATTAAAAAATGTATGCAGAGTTTTTTT
CCCCCATTTTTTCCCCTTTAAGTCATAGACCTTATCAGTTTGCCATTGGACAGCTTTCACAAGTAACAGGATTAGGGAAGGACATAATGT
ATTTAAGAATAAGTGAAGGTTAGAGGTTTACAATTAATGTTTTCTACATGTCTGTCTTCAAAGACAACATGCTTTGGAAACATATGTCCT
AGAAAACATAAAATTAAAAAAAAACACTATAGTGTAGTTTTTGGAATGTTGGAGATTATACTGGTAAAGCTGTATCGATTTGCTATTGAA
ATATAGTATTTGATACAGGAGCCATGTGTACGAATTGCAATCATGACATGGTATTTTCTATAATTATAGAGATCTTACTATTAGGATATT
GTAGCTTCATTTACCAATAAATTATTCCAAATGATTTACTGCTTTTGGAATCACAAATATTTAATTCATTTCTCTAATTTGATTCTATAA
TTTATTTGCTTCATAAAGATTCACCTGCCTAAACAATATTGAAGTATCCATAGGGCACAATTTTCAGACATTTTAGTATCTGTATATAGT
GCATATAATAAATCCAATTAAACATTATTTGATACATATTTAACTTTTTTGGCTGTATGTAATTCAGTCATAAGTAAGCATTTTCTAACG
TCCATTATATCCCTTTAGGTATTACTTAAACCAATATTATAAGTAGATAACATGTATTAGTATTTTTGTCTGTATGTCCTAGCACTGTTC
AACAACAAATTTTTCTAGTTCTTGTTAATTTTTATTTGTTATACAATGGAAGCACAATGTTATAAGGAAAGGTAATTTTAAGCTAACAAC
CAGTGCACAGCCTCAGGTTTTAAATTACAACCACAGTTGAATAATAACCTAAAAATAAATTTTAGTTTGCTAAAAATTTACAAATTTTCA
TTTTGCAGTTCCAGAGCTGCTTACCTATGTTGGTTTGCCAAAAAGAAGTGTTTAAGATATGTTTTCTGTATAAATGAACTAATTCTTTAT
ATTAAATTCCTGTCTATGCATTTTGTGAGGTACAAACTGATGAAACAGTGAGTGATAGAGAATTTCTGCCATGCTTTTAACTCCAAAGTG
AAAGTCTCTTTCTCTGGATTATTTTAAAATTTTGGCGTGTTTAACCATTAAGAAATGCTGTATTCTTAAATATGAAACAGTTAATCTAAA
GTCTTATTATTTCTTCTAGTAAAATAAAATATTGTTAGATTAGTTCTCATTAAATTTATTATATGCTAAAGAATAAAACTCCAGTTAGAT
TTAAAAAAATCCCATTTACAAGCATTGCACCTTTAAGAAGAAAACAAATATGACAGTATGGTAGCTATACTTGTGATGTCTGACGCATGA
TGGCCTATGGTTTTAAAAATAGTATTGTGGAATATATTTTTGGGTAATAAGAATGGTTGAGTGCAACATCATGTATTAATATCAAATGAA
AGACAAGGGTGCTGTATCTTTGATTATTTATCAAAAAAGTATAAATCTTTTAAGGAAAATGTTAGAATTTTAAAGTTTTTTTTTGATTGT
TGAAGCATTTATCTTGTTGATTTCTTACAAAAGAAAAAGGACGATGTCAGTCAAGCAGCACTTTTTCAGAATATACAGAACATAAATAAT
ATGATGTGGTTGAGTGTTAACATAATAAATCATATACAGTATGACATTTTAAGGAAATAAGTCTGCATTGATGTGATTGCATGCTTGTTT
TTACAGTTCACTCCATACCATCTGTGGAAAAATGCAATAATATGTTAATATAGTATGGTAGTTTGAGAGAATCAGGTAGGTGCTACTAGA
CACATTGAAACTAGAATAGGTTTATAAACTGTTCATATCTTTCAATGCATAATCTTTAGAAAGACTCCACAAAGCAAAATTCATCCTGTT
AGTACAAAATGGAAAGGTTCTTATTACAGAAGTAAGTTGTACAAACTGCATCATCAATTACTATGTAAAGCCTAATTTCAGGATGCACTT
ACAAAATTGCTACTCTTCATCGATGCCGTATTTACATCCCTCTTCATTTCATCTATATTCTACTTGGCTCCAACAACTAAATTGTTGCCT
AAATAACTCAATCATTATTTATAGCACTGTAAAATTAGAAATCCAAAATTGGTTGCATTTCATGATTTTTGACTCTTTTAACCCTTCAGA
GTAATATAAAATCTCATTAGAACTCTTATAAAACCAGTTAGCTAAAACAACTAGATTATTATACTAGTTATAAATGCTGGTATATTATAA
TTTGTGGGATCTAATTAAATGTTTGCCTATTAAATATAGTTTGATTTAAATGAGACACCATGTTCTGAACTGGAGAAAACAATATCAATG
AAGTCATATTTTCATACCTTTAAAAATTATTTAATTTTCAACCAAACAAAAAATAAATTGTAAAAATTATGCTCATTTCTATTCCAACAA
GTCAGAAAATAATGACATAATATTTCTAAATGAGAATGATGTCAATTTCATTGTCTGGAACATGCACACTTGTGTGCACATAGAGTCAAT
TTCTGTCTCTTCTAAGTGAGCACAGTAGGTAGGGAACTCAATGGAAGCAGTGTGCACACACACACACCCTTAGTAGAATATGGAGCATTA
TTCTTTACCAAAAGTAGCTATTCTCTGCCAGTGTACTGTTTACAGTGTAAATTGATTGTCCTCCGTCAAAATCAAGTCTAAGCGGCATTT
TACTTTTCTTTTCTTTTTTATTTTCCATTTTTGGGTGTTCTAGATAGGATTATTATCAAAAGTAGGAGGAAAAAGAAATGTTTGTGAGTG
CAAGATTAAAGACAGAGCGCATGAGCAGAGTACTGATGGTGTGCGTGTTTGTGTGTGTGTATATGTGTGTGTATAAGAGAGAAAGAGAAA
TCGAAAAGAGAGAGAAATTTCAACTTGTTTTCTTTTACCAGAGAATCCAAGAAGCAGTTTAAGGAACCTGATATTGGAGTTTAATCTAGA
AACTGGATGATCTCATATTGATTCATGATGCTTAATCTTTCATTGAAACTCCACAATTAAAATAACAAATAGAGAAAGAAAACTAACTTT
CCTAAATATGGCAAAGAAACTAACACCTCATTTATTTTTATTTCTTTGTAAAAATATAAATATCTCAATCAAAAGTACAGGCTCATTTGT
AATTATGTACTCATGATTGTAACAGCATTGAGATTTCATATAGGCACATGTATAGCAGCTGTTTGACAGTGATGGCTCTTCCATGTAACA
TAGCAGTTATCGTGTAATTTAGTGCCACTTATTGCAAAGTGTTACCAAGGGGAACATTTCAAATGCCTTTTGTTTTTCTTTGGACATCAA
GGTAATTTAGTGGACAACAAATATTAAATTTTACATTATGCTTTTTAATTGTGGAGAAAATGCAAAACCTCATGTCTTACCACAACTTTC
CCATGGTATTGCTAATTACTTAGAGTCTCTAAAATTGCCCAATATTATTTCCCTTTGCAAATGGTAATTTCTGATAAAACAATACAAAAC
AAAAAAAAAGCAGTAATCACAGCCAAATAAATGAAACACCTAATGAGAATTACTGTTGAGTAATGCTTTTTATTAAGTGGCACAAAGTAC
ACACTAAAAACTATGCAAAATATAGGTAACTACAGTGTACGTACATGTAAGTATCTTGTACTTGCTGTGTATGGATGTTGGAAACCCATG
TAATTATAATATGCATTTTGAATATTGGGAAAGAGGAAATCTTAGTGTAGATAATAGAATTTGTTTTGAAATATACACTGGCAATATTGA
AATATACTCAGTGCAATATCTGCAGTTCTATTGCTGGATACTTAATGCAAAGGGATTTTAAAGAATTCTTCAGCAAGATCCAAGAGGTTG
CTAATCTTCACCTCTCACATACTAAAGCATTCATTAAAAATACAACTAATTCAAGGACAAGTTAAGTTTTTCTTATTAATGTGACACAGT
AACATTTTTATTTGGATTAGTTTTTGGTGTTATTGCAGAGAAAGAAATAACCTGAGTTTTAAATTTCGATTCATATCTCATTGAATTGGG
AATTCTTCAATTTTGTTTGAAATGTGTGCATGTTTTCATAGATTGTAGCAAGTACAAATGTATTCAATGAAAGAACATAGGGTAGTTTTA
ATAGTTAAAGTCACTATATCTTAATGGGAATTTTAAAATATCTTTTCTTTTTCTATTCATTTTTTCCCTTTCTCTCTCTATTCTACCCCC
AAACAAGCCCTTTGCACTCATACCCTTCCAAAGGCAATGGATTGAAAGTAGCAAGATAATAAAGAGAGTTAAAGGGGACAACATATAACA
ATGGGTTCTAAAATCATCAGCATTTTTATGTATTGAGATTATTAATATTGAATGCAATAGTTATTGGATATAGCTGGTAAGTTCTCTGCC
ATGCATACTTACAATAATCCTTCTACCTCTCACTTTTAACATGGGCTATGATACTTCAATATAAATAGAGGAAATAATTATTTACCAGAT
ATCCCAGGAAGCATTCTTATGGAACTATTATAACAGTGCACTCCCCACCCCCTGGGAAATCTCAAAAGCCAAGTTCTTCAGTGTATTCTA
TGGTGTATGAATCTGCATTTGTTTTTCCTTTTCTATCATTAGCTTTTCCTAAAGGCAAAATATTATAACTTTATAAGAATAGTCCTTCTC
CTGCCTATTTAATATTTCAATGTTAATATAATTGTATTGGTTTTTAAAAATAATTAAAATGGCAACACTTTGCGATCCAATCTGATATTT
AATTTTTAAAATGTAACAATTTCTTATAAATTCATGCTGTGTTTTAAGTAAAAATCATGTATATGAATTATTTTACCAAGTAGTATTATC
TGCACGAGACAAATTTAAGTATTTTAAAAATCATCCTTATTAATAAATAATCCTCATATAATGCACAGTATTGCCACAAATGCCCACTTC
ATTTTGTCTGCATAGACATATTAAGAATTTTTCAATGATGTAATTTAATTATCCTAAAAGAAATGACAGATTCTTCTGTAGGAAAAAATA
AAAACATGAATATCTCAAATTATAATGGTTAATCTCTAAAATATGCTTAAAGTAAGATGTTTCTATGTTATGTGGTTATGTTATCAATAA
TATTTGGTTGATCTTCACATATTTTATATGCATATATATATCAAGAAGTTATATATATATAACTCAAGAAACTCAAGTTATATATATATG
TCAAGAAATGTATGATTATTTTGGAGAGAATGGGCCCAAATGTGAAAAAGATATAAAAAAAACAAAAAAAACAAAAAAAAAACACTATTT
TCCCCTACGAAATATACTGTATATTTCAAAAGAAGAAAAGTTAAAAGATATTTGAAGATTGCAGGGGCAAAACAAAAACCTACCAGGGCT
CAGCACTTAAGCACTTTTCCCACATCCAGGGTCAAAGCAGCAGTAACTACATGGACTTTTAAGTGCGGTATGAAATGCAACATTACGCTT
ACAAACAGTACTGTCAAACCTCAAATGCTTTCTTTCTTCAGATGCTTTTTCGTGTACATGATACTAGTAGACACTTTTCTCTTTATATTT
ACTGATAGTGAAAATCATACGCAATAAAATATTGATGTTTGAAGGCAGTGGTCACCAATTGGTTAAAAAACTATGAAATGTAAACTGAAT
TGTTATATCTCTATCCTTTTTGCTTTTCTCTGTGTTTTTAATGTATGGAATAAATCTCATAAATAGAAAGAAAAATAATCTAGAAATTTT
TCAAAGCTAGTACTCTTTCTCCTTATAAATGTACACAATTTTAATCTTTTTACAAATTTATTTAACTGTACCTACTGTACTTATTGTAGA
TTCAATGACGCAGTTAAGTCATCACCCAAGGATTTATGAATTTGAGATTACTGACCTGTTTTCTTCATATTGCATTCACATCAATATTTG
TGAATTTGTTGTTCAGCTTTTCATTCAAACAAAAAATATTCCCTCAAGAAAGCTCCATTTTTATCATAAACATTTCAACATAACCAACAT
TAGAACAAGTCTGCCATGTTAAAAATAATTTAAAGACTTATCTCTGAAAACGGTATCCAGAAACGCAGGTGTTCCCAGTAATGTAGCTTC
AAAAATAAAATGTGCTATTTATATGACATGAAATTCATAACTTTTGGAAGGGTATATTTATGACAGCATAAAAAATAAATTCTGTGCTAT
AAAGAAGATCCAACAAATTAACCATATAAGCACAGAAAATAGAGAAACACAGTTATTGAATCTACTCTTGTCATTAACATTTTCAAAAAA
CAAAATGCATATTGTAATATTTGGTACATGACACTTGCATGTTGATATGCCTATATACTTACAAAGTATTCAATGTGTACTTAGCGGCGC
TTAAAATATGTCATGTACAACTCTTATAAACATTTTTACAGGGTTCCCATTTGCACTTCATCTTTCAGTAAAGTCTTGTCAGAAAAAAAT
TGTCTGATAAATATGGAAAAATAAAATTTGAATTTTAGTTATCTGTTGGACATTACTGAATTGTCTATTCATTTAGTACATTTTCTTAAC
CTTGAAAACAGACATTGAAAGATGGAACTTTCTTTTTTCCAGTGACAGGTCATTAAATCGATGGTACAAAACATACTTCTTTATGCCAAA
CACATTATTTTGAATACCTTTTTTTCAACTTCATACATTATCCATCCATTTTAGTTTTCCTCGATGATGCCCATTTTCTTTGTAAATTTC
TAAGTGGAAGTTTTAAAAATTAAGCATCAGTAAAATAAATGTTATCTTATTTGTACAACATTTAATCGTTATTCCTTGGAATATATGAAC
CTTGTAAAGTGATGACTAAGGGTCAAAAAAAATGTTGCTGACTTAGGGAAATTTGCTTGAGAATGCCAAAATTTTAAAACTCTGTAAAGG
TAATTTTACATTCACTTATGTGTGTTTACTAATGTTGAGTAGGAACAGAAGCAAAAATACCTAAACCTATTTTTTTTAACCTTCACACTC
TAACCAGTATTATATATTTCAGCTACCTAAGATAATGCAATTAATCATATATCCAACCTAAGCTTCTGCCAATAAGGATTTCAGATAAGC
TTTTAAATTTATGGAGGATTTTCTTTGTGTCTTTGGAAGTTCACTTACCATAAAGTATTTTATAGTCTACTTTAAATAACAGATTTTGTT
ACACAGGGTAAGCCAAAGGCTGTACAAGATTTAGTGTCATTGGGTCTCATATTTGTGTTAGACCATGAAATATTCCATTAAAATTTATCT

>90322_90322_1_TFEB-CADM2_TFEB_chr6_41653828_ENST00000373033_CADM2_chr3_85851197_ENST00000383699_length(amino acids)=421AA_BP=46
MEQGHHPQGLCGLHPEDAEGPAKVQGAGEPLSPPGDDQQAALAPYPGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTL
YFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPA
ADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPL
ILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDPNALAGQNGPDHALIGGIV

--------------------------------------------------------------
>90322_90322_2_TFEB-CADM2_TFEB_chr6_41653828_ENST00000373033_CADM2_chr3_85851197_ENST00000405615_length(transcript)=2479nt_BP=1232nt
GTGGAGTGACAGCCGGAGCCCGGGCGCCGGGCGCGGGGCTCGGTGACAGCGGAGGCGGCGGCCCGGGCGGGACGCAGGGAGCGGCCGCGG
CGCCGACGGCGGCGGGAAGGGCGGACGGGGCGGGCCTCCCTGGTGGCACGGGGCCGGAGCAGGCCGGGAGCAGGTGGCGGGCACAGCTTG
CGGGCCAGGCACCCGAACTTGCGACAAGTTGCCGGAGCCGCGGGGCGCGGGCGGCGGACAGATTGACCTTCAGAGCGAGGGAGCCAGCGC
CGGCAGCCACCATGGCGTCACGCATAGGGTTGCGCATGCAGCTCATGCGGGAGCAGGCGCAGCAGGAGGAGCAGCGGGAGCGCATGCAGC
AACAGGCTGTCATGCATTACATGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCTCGGAGGGCCGCCCACCCCGGCCATCAATACCCCCG
TCCACTTCCAGTCGCCACCACCTGTGCCTGGGGAGGTGTTGAAGGTGCAGTCCTACCTGGAGAATCCCACATCCTACCATCTGCAGCAGT
CGCAGCATCAGAAGGTGCGGGAGTACCTGTCCGAGACCTATGGGAACAAGTTTGCTGCCCACATCAGCCCAGCCCAGGGCTCTCCGAAAC
CCCCACCAGCCGCCTCCCCAGGGGTGCGAGCTGGACACGTGCTGTCCTCCTCCGCTGGCAACAGTGCTCCCAATAGCCCCATGGCCATGC
TGCACATTGGCTCCAACCCTGAGAGGGAGTTGGATGATGTCATTGACAACATTATGCGTCTGGACGATGTCCTTGGCTACATCAATCCTG
AAATGCAGATGCCCAACACGCTACCCCTGTCCAGCAGCCACCTGAATGTGTACAGCAGCGACCCCCAGGTCACAGCCTCCCTGGTGGGCG
TCACCAGCAGCTCCTGCCCTGCGGACCTGACCCAGAAGCGAGAGCTCACAGATGCTGAGAGCAGGGCCCTGGCCAAGGAGCGGCAGAAGA
AAGACAATCACAACTTAATTGAAAGGAGACGAAGGTTCAACATCAATGACCGCATCAAGGAGTTGGGAATGCTGATCCCCAAGGCCAATG
ACCTGGACGTGCGCTGGAACAAGGGCACCATCCTCAAGGCCTCTGTGGATTACATCCGGAGGATGCAGAAGGACCTGCAAAAGTCCAGGG
AGCTGGAGAACCACTCTCGCCGCCTGGAGATGACCAACAAGCAGCTCTGGCTCCGTATCCAGGCAGCCAAGGGCAGTTTCCACTAACACA
GAATGTAACCGTTGTTGAAGGTGGAACTGCAATTTTGACCTGCAGGGTTGATCAAAATGATAACACCTCCCTCCAGTGGTCAAATCCAGC
TCAACAGACTCTGTACTTTGACGACAAGAAAGCTTTAAGGGACAATAGGATCGAGCTGGTTCGCGCTTCCTGGCATGAATTGAGTATTAG
TGTCAGTGATGTGTCTCTCTCTGATGAAGGACAGTACACCTGTTCTTTATTTACAATGCCTGTCAAAACTTCCAAGGCATATCTCACCGT
TCTGGGTGTTCCTGAAAAGCCTCAGATTAGTGGATTCTCATCACCAGTTATGGAGGGTGACTTGATGCAGCTGACTTGCAAAACATCTGG
TAGTAAACCTGCAGCTGATATAAGATGGTTCAAAAATGACAAAGAGATTAAAGATGTAAAATATTTAAAAGAAGAGGATGCAAATCGCAA
GACATTCACTGTCAGCAGCACACTGGACTTCCGAGTGGACCGGAGTGATGATGGAGTGGCGGTCATCTGCAGAGTAGATCACGAATCCCT
CAATGCCACCCCTCAGGTAGCCATGCAGGTGCTAGAAATACACTATACACCATCAGTTAAGATTATACCATCGACTCCTTTTCCACAAGA
AGGACAGCCTTTAATTTTGACTTGTGAATCCAAAGGAAAACCACTGCCAGAACCTGTTTTGTGGACAAAGGATGGCGGAGAATTACCAGA
TCCTGACCGAATGGTTGTGAGTGGTAGGGAGCTAAACATTCTTTTCCTGAACAAAACGGATAATGGTACATATCGATGTGAAGCCACAAA
CACCATTGGCCAAAGCAGTGCGGAATATGTTCTCATTGTGCATGATGTTCCCAACACTTTGCTTCCCACTACTATCATCCCCTCCCTTAC
CACTGCAACAGTCACAACCACTGTAGCCATAACAACCAGCCCAACCACATCTGCAACAACCAGCAGCATCAGAGATCCTAATGCTTTGGC
TGGCCAGAATGGCCCTGACCATGCTCTCATAGGAGGAATAGTGGCTGTAGTTGTATTTGTCACGCTGTGTTCTATCTTTCTGCTTGGTCG
ATATCTGGCAAGGCATAAAGGAACGTATTTAACAAATGAAGCTAAAGGAGCTGAAGATGCACCAGATGCTGATACAGCCATTATCAATGC

>90322_90322_2_TFEB-CADM2_TFEB_chr6_41653828_ENST00000373033_CADM2_chr3_85851197_ENST00000405615_length(amino acids)=462AA_BP=46
MEQGHHPQGLCGLHPEDAEGPAKVQGAGEPLSPPGDDQQAALAPYPGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTL
YFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPA
ADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPL
ILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTATV
TTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQ

--------------------------------------------------------------
>90322_90322_3_TFEB-CADM2_TFEB_chr6_41653828_ENST00000373033_CADM2_chr3_85851197_ENST00000407528_length(transcript)=2531nt_BP=1232nt
GTGGAGTGACAGCCGGAGCCCGGGCGCCGGGCGCGGGGCTCGGTGACAGCGGAGGCGGCGGCCCGGGCGGGACGCAGGGAGCGGCCGCGG
CGCCGACGGCGGCGGGAAGGGCGGACGGGGCGGGCCTCCCTGGTGGCACGGGGCCGGAGCAGGCCGGGAGCAGGTGGCGGGCACAGCTTG
CGGGCCAGGCACCCGAACTTGCGACAAGTTGCCGGAGCCGCGGGGCGCGGGCGGCGGACAGATTGACCTTCAGAGCGAGGGAGCCAGCGC
CGGCAGCCACCATGGCGTCACGCATAGGGTTGCGCATGCAGCTCATGCGGGAGCAGGCGCAGCAGGAGGAGCAGCGGGAGCGCATGCAGC
AACAGGCTGTCATGCATTACATGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCTCGGAGGGCCGCCCACCCCGGCCATCAATACCCCCG
TCCACTTCCAGTCGCCACCACCTGTGCCTGGGGAGGTGTTGAAGGTGCAGTCCTACCTGGAGAATCCCACATCCTACCATCTGCAGCAGT
CGCAGCATCAGAAGGTGCGGGAGTACCTGTCCGAGACCTATGGGAACAAGTTTGCTGCCCACATCAGCCCAGCCCAGGGCTCTCCGAAAC
CCCCACCAGCCGCCTCCCCAGGGGTGCGAGCTGGACACGTGCTGTCCTCCTCCGCTGGCAACAGTGCTCCCAATAGCCCCATGGCCATGC
TGCACATTGGCTCCAACCCTGAGAGGGAGTTGGATGATGTCATTGACAACATTATGCGTCTGGACGATGTCCTTGGCTACATCAATCCTG
AAATGCAGATGCCCAACACGCTACCCCTGTCCAGCAGCCACCTGAATGTGTACAGCAGCGACCCCCAGGTCACAGCCTCCCTGGTGGGCG
TCACCAGCAGCTCCTGCCCTGCGGACCTGACCCAGAAGCGAGAGCTCACAGATGCTGAGAGCAGGGCCCTGGCCAAGGAGCGGCAGAAGA
AAGACAATCACAACTTAATTGAAAGGAGACGAAGGTTCAACATCAATGACCGCATCAAGGAGTTGGGAATGCTGATCCCCAAGGCCAATG
ACCTGGACGTGCGCTGGAACAAGGGCACCATCCTCAAGGCCTCTGTGGATTACATCCGGAGGATGCAGAAGGACCTGCAAAAGTCCAGGG
AGCTGGAGAACCACTCTCGCCGCCTGGAGATGACCAACAAGCAGCTCTGGCTCCGTATCCAGGCAGCCAAGGGCAGTTTCCACTAACACA
GAATGTAACCGTTGTTGAAGGTGGAACTGCAATTTTGACCTGCAGGGTTGATCAAAATGATAACACCTCCCTCCAGTGGTCAAATCCAGC
TCAACAGACTCTGTACTTTGACGACAAGAAAGCTTTAAGGGACAATAGGATCGAGCTGGTTCGCGCTTCCTGGCATGAATTGAGTATTAG
TGTCAGTGATGTGTCTCTCTCTGATGAAGGACAGTACACCTGTTCTTTATTTACAATGCCTGTCAAAACTTCCAAGGCATATCTCACCGT
TCTGGGTGTTCCTGAAAAGCCTCAGATTAGTGGATTCTCATCACCAGTTATGGAGGGTGACTTGATGCAGCTGACTTGCAAAACATCTGG
TAGTAAACCTGCAGCTGATATAAGATGGTTCAAAAATGACAAAGAGATTAAAGATGTAAAATATTTAAAAGAAGAGGATGCAAATCGCAA
GACATTCACTGTCAGCAGCACACTGGACTTCCGAGTGGACCGGAGTGATGATGGAGTGGCGGTCATCTGCAGAGTAGATCACGAATCCCT
CAATGCCACCCCTCAGGTAGCCATGCAGGTGCTAGAAATACACTATACACCATCAGTTAAGATTATACCATCGACTCCTTTTCCACAAGA
AGGACAGCCTTTAATTTTGACTTGTGAATCCAAAGGAAAACCACTGCCAGAACCTGTTTTGTGGACAAAGGATGGCGGAGAATTACCAGA
TCCTGACCGAATGGTTGTGAGTGGTAGGGAGCTAAACATTCTTTTCCTGAACAAAACGGATAATGGTACATATCGATGTGAAGCCACAAA
CACCATTGGCCAAAGCAGTGCGGAATATGTTCTCATTGTGCATGATGTTCCCAACACTTTGCTTCCCACTACTATCATCCCCTCCCTTAC
CACTGCAACAGTCACAACCACTGTAGCCATAACAACCAGCCCAACCACATCTGCAACAACCAGCAGCATCAGAGATCCTAATGCTTTGGC
TGGCCAGAATGGCCCTGACCATGCTCTCATAGGAGGAATAGTGGCTGTAGTTGTATTTGTCACGCTGTGTTCTATCTTTCTGCTTGGTCG
ATATCTGGCAAGGCATAAAGGAACGTATTTAACAAATGAAGCTAAAGGAGCTGAAGATGCACCAGATGCTGATACAGCCATTATCAATGC
TGAAGGCAGCCAAGTCAATGCTGAAGAGAAAAAAGAGTATTTCATTTAAGATGCAGGCCAAGATTCTGAGTTTTACTACCAGGCTGAATG

>90322_90322_3_TFEB-CADM2_TFEB_chr6_41653828_ENST00000373033_CADM2_chr3_85851197_ENST00000407528_length(amino acids)=461AA_BP=46
MEQGHHPQGLCGLHPEDAEGPAKVQGAGEPLSPPGDDQQAALAPYPGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTL
YFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPA
ADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPL
ILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTATV
TTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TFEB-CADM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TFEB-CADM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TFEB-CADM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource