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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:TGFB2-WLS (FusionGDB2 ID:90437)

Fusion Gene Summary for TGFB2-WLS

Fusion gene summary

Fusion gene information	Fusion gene name: TGFB2-WLS
	Fusion gene ID: 90437
		Hgene	Tgene
	Gene symbol	TGFB2	WLS
	Gene ID	7042	79971
	Gene name	transforming growth factor beta 2	Wnt ligand secretion mediator
	Synonyms	G-TSF\|LDS4\|TGF-beta2	C1orf139\|EVI\|GPR177\|MRP\|mig-14
	Cytomap	1q41	1p31.3
	Type of gene	protein-coding	protein-coding
	Description	transforming growth factor beta-2 proproteinBSC-1 cell growth inhibitorceterminglioblastoma-derived T-cell suppressor factorpolyerginprepro-transforming growth factor beta-2	protein wntless homologG protein-coupled receptor 177integral membrane protein GPR177protein evenness interrupted homologputative NF-kappa-B-activating protein 373putative NFkB activating protein 373wntless Wnt ligand secretion mediator
	Modification date	20200322	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000366929, ENST00000366930, ENST00000479322,	ENST00000370971, ENST00000370976, ENST00000491811, ENST00000262348, ENST00000354777, ENST00000540432,
Fusion gene scores	* DoF score	5 X 5 X 3=75	13 X 8 X 7=728
	# samples	5	13
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/728*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TGFB2 [Title/Abstract] AND WLS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TGFB2(218536759)-WLS(68659910), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TGFB2	GO:0000902	cell morphogenesis	15896309
Hgene	TGFB2	GO:0001654	eye development	15944186
Hgene	TGFB2	GO:0001837	epithelial to mesenchymal transition	10092230\|18223299
Hgene	TGFB2	GO:0001942	hair follicle development	10433821
Hgene	TGFB2	GO:0003007	heart morphogenesis	10092230
Hgene	TGFB2	GO:0006468	protein phosphorylation	18358889
Hgene	TGFB2	GO:0007050	cell cycle arrest	18223299
Hgene	TGFB2	GO:0007179	transforming growth factor beta receptor signaling pathway	11157754\|18358889
Hgene	TGFB2	GO:0007507	heart development	15896309
Hgene	TGFB2	GO:0008219	cell death	16227582
Hgene	TGFB2	GO:0008284	positive regulation of cell proliferation	15896309
Hgene	TGFB2	GO:0008285	negative regulation of cell proliferation	15944186
Hgene	TGFB2	GO:0008347	glial cell migration	18431253
Hgene	TGFB2	GO:0010002	cardioblast differentiation	15896309
Hgene	TGFB2	GO:0010629	negative regulation of gene expression	25217442
Hgene	TGFB2	GO:0010634	positive regulation of epithelial cell migration	17960115
Hgene	TGFB2	GO:0010693	negative regulation of alkaline phosphatase activity	18358889
Hgene	TGFB2	GO:0010718	positive regulation of epithelial to mesenchymal transition	17999987\|18505915
Hgene	TGFB2	GO:0010936	negative regulation of macrophage cytokine production	20875417
Hgene	TGFB2	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	18223299
Hgene	TGFB2	GO:0016477	cell migration	10092230
Hgene	TGFB2	GO:0016525	negative regulation of angiogenesis	25217442\|28977001
Hgene	TGFB2	GO:0030199	collagen fibril organization	16891397
Hgene	TGFB2	GO:0030307	positive regulation of cell growth	15896309\|20573232
Hgene	TGFB2	GO:0030308	negative regulation of cell growth	18358889
Hgene	TGFB2	GO:0032147	activation of protein kinase activity	17192487\|17960115
Hgene	TGFB2	GO:0032570	response to progesterone	18039789
Hgene	TGFB2	GO:0032874	positive regulation of stress-activated MAPK cascade	17192487
Hgene	TGFB2	GO:0033630	positive regulation of cell adhesion mediated by integrin	17960115\|18223299
Hgene	TGFB2	GO:0042493	response to drug	20573232
Hgene	TGFB2	GO:0043525	positive regulation of neuron apoptotic process	16227582
Hgene	TGFB2	GO:0045216	cell-cell junction organization	18505915
Hgene	TGFB2	GO:0045726	positive regulation of integrin biosynthetic process	17960115
Hgene	TGFB2	GO:0045747	positive regulation of Notch signaling pathway	25217442
Hgene	TGFB2	GO:0045823	positive regulation of heart contraction	15896309
Hgene	TGFB2	GO:0050680	negative regulation of epithelial cell proliferation	17217916
Hgene	TGFB2	GO:0050714	positive regulation of protein secretion	18505915
Hgene	TGFB2	GO:0051794	regulation of timing of catagen	15955085
Hgene	TGFB2	GO:0051795	positive regulation of timing of catagen	15955085
Hgene	TGFB2	GO:0051891	positive regulation of cardioblast differentiation	15896309
Hgene	TGFB2	GO:0060038	cardiac muscle cell proliferation	15896309
Hgene	TGFB2	GO:0060317	cardiac epithelial to mesenchymal transition	10092230
Hgene	TGFB2	GO:0060389	pathway-restricted SMAD protein phosphorylation	11157754\|18358889
Hgene	TGFB2	GO:0060395	SMAD protein signal transduction	17192487
Hgene	TGFB2	GO:0097191	extrinsic apoptotic signaling pathway	17217916
Hgene	TGFB2	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	25217442

Fusion gene breakpoints across TGFB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WLS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-EL-A3D0	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-

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Fusion Gene ORF analysis for TGFB2-WLS

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000366929	ENST00000370971	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
5CDS-intron	ENST00000366929	ENST00000370976	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
5CDS-intron	ENST00000366929	ENST00000491811	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
In-frame	ENST00000366929	ENST00000262348	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
In-frame	ENST00000366929	ENST00000354777	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
In-frame	ENST00000366929	ENST00000540432	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-3CDS	ENST00000366930	ENST00000262348	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-3CDS	ENST00000366930	ENST00000354777	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-3CDS	ENST00000366930	ENST00000540432	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-3CDS	ENST00000479322	ENST00000262348	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-3CDS	ENST00000479322	ENST00000354777	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-3CDS	ENST00000479322	ENST00000540432	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-intron	ENST00000366930	ENST00000370971	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-intron	ENST00000366930	ENST00000370976	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-intron	ENST00000366930	ENST00000491811	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-intron	ENST00000479322	ENST00000370971	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-intron	ENST00000479322	ENST00000370976	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-
intron-intron	ENST00000479322	ENST00000491811	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366929	TGFB2	chr1	218536759	+	ENST00000540432	WLS	chr1	68659910	-	2602	897	467	2428	653
ENST00000366929	TGFB2	chr1	218536759	+	ENST00000354777	WLS	chr1	68659910	-	2582	897	467	2422	651
ENST00000366929	TGFB2	chr1	218536759	+	ENST00000262348	WLS	chr1	68659910	-	3285	897	467	2416	649

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366929	ENST00000540432	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-	0.00096214	0.99903786
ENST00000366929	ENST00000354777	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-	0.001190949	0.9988091
ENST00000366929	ENST00000262348	TGFB2	chr1	218536759	+	WLS	chr1	68659910	-	0.000539037	0.999461

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Fusion Genomic Features for TGFB2-WLS

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TGFB2-WLS

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:218536759/chr1:68659910)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

254_268

542.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

290_303

542.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

325_331

542.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

353_380

542.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

37_232

542.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

402_431

542.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

453_471

542.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

493_541

542.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

254_268

544.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

290_303

544.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

325_331

544.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

353_380

544.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

37_232

544.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

402_431

544.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

453_471

544.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

493_541

544.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

1_15

451.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

254_268

451.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

290_303

451.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

325_331

451.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

353_380

451.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

37_232

451.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

402_431

451.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

453_471

451.0

Topological domain

Lumenal

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

493_541

451.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

233_253

542.0

Transmembrane

Helical%3B Name%3D2

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

269_289

542.0

Transmembrane

Helical%3B Name%3D3

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

304_324

542.0

Transmembrane

Helical%3B Name%3D4

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

332_352

542.0

Transmembrane

Helical%3B Name%3D5

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

381_401

542.0

Transmembrane

Helical%3B Name%3D6

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

432_452

542.0

Transmembrane

Helical%3B Name%3D7

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

472_492

542.0

Transmembrane

Helical%3B Name%3D8

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

233_253

544.0

Transmembrane

Helical%3B Name%3D2

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

269_289

544.0

Transmembrane

Helical%3B Name%3D3

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

304_324

544.0

Transmembrane

Helical%3B Name%3D4

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

332_352

544.0

Transmembrane

Helical%3B Name%3D5

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

381_401

544.0

Transmembrane

Helical%3B Name%3D6

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

432_452

544.0

Transmembrane

Helical%3B Name%3D7

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

472_492

544.0

Transmembrane

Helical%3B Name%3D8

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

16_36

451.0

Transmembrane

Helical%3B Name%3D1

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

233_253

451.0

Transmembrane

Helical%3B Name%3D2

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

269_289

451.0

Transmembrane

Helical%3B Name%3D3

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

304_324

451.0

Transmembrane

Helical%3B Name%3D4

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

332_352

451.0

Transmembrane

Helical%3B Name%3D5

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

381_401

451.0

Transmembrane

Helical%3B Name%3D6

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

432_452

451.0

Transmembrane

Helical%3B Name%3D7

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000370976

472_492

451.0

Transmembrane

Helical%3B Name%3D8

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

1_15

542.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

1_15

544.0

Topological domain

Cytoplasmic

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000262348

16_36

542.0

Transmembrane

Helical%3B Name%3D1

Tgene

WLS

chr1:218536759

chr1:68659910

ENST00000354777

16_36

544.0

Transmembrane

Helical%3B Name%3D1

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Fusion Gene Sequence for TGFB2-WLS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>90437_90437_1_TGFB2-WLS_TGFB2_chr1_218536759_ENST00000366929_WLS_chr1_68659910_ENST00000262348_length(transcript)=3285nt_BP=897nt
GCCCCTCCCGTCAGTTCGCCAGCTGCCAGCCCCGGGACCTTTTCATCTCTTCCCTTTTGGCCGGAGGAGCCGAGTTCAGATCCGCCACTC
CGCACCCGAGACTGACACACTGAACTCCACTTCCTCCTCTTAAATTTATTTCTACTTAATAGCCACTCGTCTCTTTTTTTCCCCATCTCA
TTGCTCCAAGAATTTTTTTCTTCTTACTCGCCAAAGTCAGGGTTCCCTCTGCCCGTCCCGTATTAATATTTCCACTTTTGGAACTACTGG
CCTTTTCTTTTTAAAGGAATTCAAGCAGGATACGTTTTTCTGTTGGGCATTGACTAGATTGTTTGCAAAAGTTTCGCATCAAAAACAACA
ACAACAAAAAACCAAACAACTCTCCTTGATCTATACTTTGAGAATTGTTGATTTCTTTTTTTTATTCTGACTTTTAAAAACAACTTTTTT
TTCCACTTTTTTAAAAAATGCACTACTGTGTGCTGAGCGCTTTTCTGATCCTGCATCTGGTCACGGTCGCGCTCAGCCTGTCTACCTGCA
GCACACTCGATATGGACCAGTTCATGCGCAAGAGGATCGAGGCGATCCGCGGGCAGATCCTGAGCAAGCTGAAGCTCACCAGTCCCCCAG
AAGACTATCCTGAGCCCGAGGAAGTCCCCCCGGAGGTGATTTCCATCTACAACAGCACCAGGGACTTGCTCCAGGAGAAGGCGAGCCGGA
GGGCGGCCGCCTGCGAGCGCGAGAGGAGCGACGAAGAGTACTACGCCAAGGAGGTTTACAAAATAGACATGCCGCCCTTCTTCCCCTCCG
AAACTGTCTGCCCAGTTGTTACAACACCCTCTGGCTCAGTGGGCAGCTTGTGCTCCAGACAGTCCCAGGTGCTCTGTGGGTACCTTGCTC
CAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTTGGG
GACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACATTC
CCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAATCA
GAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTAC
CACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAA
TTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAA
AGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCA
TCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCA
TGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCT
TCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGA
AGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACA
GTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTAT
GCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGG
GGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGG
AAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTG
CTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGCGATCTGGGTGTCCATAGTGGGGAAGAACTCC
AGCTCACCACCACTATCACCCATGTGGACGGACCCACTGAGATCTACAAGTTGACCCGCAAGGAGGCCCAGGAGTAGGAGGCTGCAGCGC
CCGGCTGGGACGGTCTCTCCATACCCCAGCCCCTCTAACTAGAGTGGGGAGCATGCCAGAGAGAGCTCAATGTACAAATGAATGCCTCAT
GGCTCTTAGCTGTGGTTTCTTGGACCAGCGGCATGGACATTTGTCAGTTTGCCTTCTGACGGTAGCTTTTGGAGGAAGATTCCTGCAGCC
ACTAATGCATTGTGTATGATAACAAAAACTCTGGTATGACACATTTTCTGTGATCATTGTTAATTAGTGACATAGTAACATCTGTAGCAG
CTGGTTAGTAAACCTCATGTGGGGGTGGGGTGGGGGTGTATTCCTTGGGGGATGGTTTGGGCCGAATGGGGAGTGGAATATTTGACATTT
TTCCTGTTTTAAATTCTAGGATAGATTTTAACATCCTTTGCGGTCCCAGTCCAAGGTAGGCTGGTGTCATAGTCTTCTCACTCCTAATCC
ATGACCACTGTTTTTTTCCTATTTATATCACCAGGTAGCCCACTGAGTTAATATTTAAGTTGTCAATAGATAAGTGTCCCTGTTTTGTGG
CATAATATAACTGAATTTCATGAGAAGATTTATTCCACCAGGGGTATTTCAGCTTTGAAACCAAATCTGTGTATCTAATACTAACCAATC
TGTTGGATGTGGGTTTTAAAAAATGTTTGCTAAACTACCCAAGTAAGATTTACTGTATTAAATGGCCTTCGGGTCTGAAAAGCTTTTTTA
ACTTCTTGCTTAAAATGCGTTTTATTTTGATAAGATACTTCAAATAGCCTCCAAAAGTGTAGATCCAATCATTTAAATAAACCTGTATGT

>90437_90437_1_TGFB2-WLS_TGFB2_chr1_218536759_ENST00000366929_WLS_chr1_68659910_ENST00000262348_length(amino acids)=649AA_BP=143
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACE
RERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCD
KIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKC
TFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWY
WRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPI
AVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRF
KFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTI

--------------------------------------------------------------
>90437_90437_2_TGFB2-WLS_TGFB2_chr1_218536759_ENST00000366929_WLS_chr1_68659910_ENST00000354777_length(transcript)=2582nt_BP=897nt
GCCCCTCCCGTCAGTTCGCCAGCTGCCAGCCCCGGGACCTTTTCATCTCTTCCCTTTTGGCCGGAGGAGCCGAGTTCAGATCCGCCACTC
CGCACCCGAGACTGACACACTGAACTCCACTTCCTCCTCTTAAATTTATTTCTACTTAATAGCCACTCGTCTCTTTTTTTCCCCATCTCA
TTGCTCCAAGAATTTTTTTCTTCTTACTCGCCAAAGTCAGGGTTCCCTCTGCCCGTCCCGTATTAATATTTCCACTTTTGGAACTACTGG
CCTTTTCTTTTTAAAGGAATTCAAGCAGGATACGTTTTTCTGTTGGGCATTGACTAGATTGTTTGCAAAAGTTTCGCATCAAAAACAACA
ACAACAAAAAACCAAACAACTCTCCTTGATCTATACTTTGAGAATTGTTGATTTCTTTTTTTTATTCTGACTTTTAAAAACAACTTTTTT
TTCCACTTTTTTAAAAAATGCACTACTGTGTGCTGAGCGCTTTTCTGATCCTGCATCTGGTCACGGTCGCGCTCAGCCTGTCTACCTGCA
GCACACTCGATATGGACCAGTTCATGCGCAAGAGGATCGAGGCGATCCGCGGGCAGATCCTGAGCAAGCTGAAGCTCACCAGTCCCCCAG
AAGACTATCCTGAGCCCGAGGAAGTCCCCCCGGAGGTGATTTCCATCTACAACAGCACCAGGGACTTGCTCCAGGAGAAGGCGAGCCGGA
GGGCGGCCGCCTGCGAGCGCGAGAGGAGCGACGAAGAGTACTACGCCAAGGAGGTTTACAAAATAGACATGCCGCCCTTCTTCCCCTCCG
AAACTGTCTGCCCAGTTGTTACAACACCCTCTGGCTCAGTGGGCAGCTTGTGCTCCAGACAGTCCCAGGTGCTCTGTGGGTACCTTGGGC
CCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTTGGGGACCCA
ATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACATTCCCCTCC
CCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAATCAGAGAAA
ATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTACCACGGA
AACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAATTGGGT
CTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAAAGGATA
TCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCATCATTA
TGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCATGACCT
TTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCTTCTATG
CGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGAAGCAAG
TCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACAGTATCT
GGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTATGCTTCA
TGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGGGGCTAA
TTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGGAAGGCC
ATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTGCTCTGA
TGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGAATGCAACTCCCATGTAAATCGAGGGAAGATTGTGCTT
TGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCGAAATATTCCTTCATCAATGACAACGCAGCTTCTGGTATTTGAGTCAACA
AGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCACAGTCACATTGATTGTACTTGTATACGCACACAAATACACTCATTTAGCC

>90437_90437_2_TGFB2-WLS_TGFB2_chr1_218536759_ENST00000366929_WLS_chr1_68659910_ENST00000354777_length(amino acids)=651AA_BP=143
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACE
RERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKI
RDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTF
TSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWR
RITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAV
GSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKF
LMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGMQLPCKSREDCALFVSEL

--------------------------------------------------------------
>90437_90437_3_TGFB2-WLS_TGFB2_chr1_218536759_ENST00000366929_WLS_chr1_68659910_ENST00000540432_length(transcript)=2602nt_BP=897nt
GCCCCTCCCGTCAGTTCGCCAGCTGCCAGCCCCGGGACCTTTTCATCTCTTCCCTTTTGGCCGGAGGAGCCGAGTTCAGATCCGCCACTC
CGCACCCGAGACTGACACACTGAACTCCACTTCCTCCTCTTAAATTTATTTCTACTTAATAGCCACTCGTCTCTTTTTTTCCCCATCTCA
TTGCTCCAAGAATTTTTTTCTTCTTACTCGCCAAAGTCAGGGTTCCCTCTGCCCGTCCCGTATTAATATTTCCACTTTTGGAACTACTGG
CCTTTTCTTTTTAAAGGAATTCAAGCAGGATACGTTTTTCTGTTGGGCATTGACTAGATTGTTTGCAAAAGTTTCGCATCAAAAACAACA
ACAACAAAAAACCAAACAACTCTCCTTGATCTATACTTTGAGAATTGTTGATTTCTTTTTTTTATTCTGACTTTTAAAAACAACTTTTTT
TTCCACTTTTTTAAAAAATGCACTACTGTGTGCTGAGCGCTTTTCTGATCCTGCATCTGGTCACGGTCGCGCTCAGCCTGTCTACCTGCA
GCACACTCGATATGGACCAGTTCATGCGCAAGAGGATCGAGGCGATCCGCGGGCAGATCCTGAGCAAGCTGAAGCTCACCAGTCCCCCAG
AAGACTATCCTGAGCCCGAGGAAGTCCCCCCGGAGGTGATTTCCATCTACAACAGCACCAGGGACTTGCTCCAGGAGAAGGCGAGCCGGA
GGGCGGCCGCCTGCGAGCGCGAGAGGAGCGACGAAGAGTACTACGCCAAGGAGGTTTACAAAATAGACATGCCGCCCTTCTTCCCCTCCG
AAACTGTCTGCCCAGTTGTTACAACACCCTCTGGCTCAGTGGGCAGCTTGTGCTCCAGACAGTCCCAGGTGCTCTGTGGGTACCTTGCTC
CAGGGCCCACAACGGCAGTGTCCTACATGTCGGTGAAATGTGTGGATGCCCGTAAGAACCATCACAAGACAAAATGGTTCGTGCCTTGGG
GACCCAATCATTGTGACAAGATCCGAGACATTGAAGAGGCAATTCCAAGGGAAATTGAAGCCAATGACATCGTGTTTTCTGTTCACATTC
CCCTCCCCCACATGGAGATGAGTCCTTGGTTCCAATTCATGCTGTTTATCCTGCAGCTGGACATTGCCTTCAAGCTAAACAACCAAATCA
GAGAAAATGCAGAAGTCTCCATGGACGTTTCCCTGGCTTACCGTGATGACGCGTTTGCTGAGTGGACTGAAATGGCCCATGAAAGAGTAC
CACGGAAACTCAAATGCACCTTCACATCTCCCAAGACTCCAGAGCATGAGGGCCGTTACTATGAATGTGATGTCCTTCCTTTCATGGAAA
TTGGGTCTGTGGCCCATAAGTTTTACCTTTTAAACATCCGGCTGCCTGTGAATGAGAAGAAGAAAATCAATGTGGGAATTGGGGAGATAA
AGGATATCCGGTTGGTGGGGATCCACCAAAATGGAGGCTTCACCAAGGTGTGGTTTGCCATGAAGACCTTCCTTACGCCCAGCATCTTCA
TCATTATGGTGTGGTATTGGAGGAGGATCACCATGATGTCCCGACCCCCAGTGCTTCTGGAAAAAGTCATCTTTGCCCTTGGGATTTCCA
TGACCTTTATCAATATCCCAGTGGAATGGTTTTCCATCGGGTTTGACTGGACCTGGATGCTGCTGTTTGGTGACATCCGACAGGGCATCT
TCTATGCGATGCTTCTGTCCTTCTGGATCATCTTCTGTGGCGAGCACATGATGGATCAGCACGAGCGGAACCACATCGCAGGGTATTGGA
AGCAAGTCGGACCCATTGCCGTTGGCTCCTTCTGCCTCTTCATATTTGACATGTGTGAGAGAGGGGTACAACTCACGAATCCCTTCTACA
GTATCTGGACTACAGACATTGGAACAGAGCTGGCCATGGCCTTCATCATCGTGGCTGGAATCTGCCTCTGCCTCTACTTCCTGTTTCTAT
GCTTCATGGTATTTCAGGTGTTTCGGAACATCAGTGGGAAGCAGTCCAGCCTGCCAGCTATGAGCAAAGTCCGGCGGCTACACTATGAGG
GGCTAATTTTTAGGTTCAAGTTCCTCATGCTTATCACCTTGGCCTGCGCTGCCATGACTGTCATCTTCTTCATCGTTAGTCAGGTAACGG
AAGGCCATTGGAAATGGGGCGGCGTCACAGTCCAAGTGAACAGTGCCTTTTTCACAGGCATCTATGGGATGTGGAATCTGTATGTCTTTG
CTCTGATGTTCTTGTATGCACCATCCCATAAAAACTATGGAGAAGACCAGTCCAATGGAATGCAACTCCCATGTAAATCGAGGGAAGATT
GTGCTTTGTTTGTTTCGGAACTTTATCAAGAATTGTTCAGCGCTTCGAAATATTCCTTCATCAATGACAACGCAGCTTCTGGTATTTGAG
TCAACAAGGCAACACATGTTTATCAGCTTTGCATTTGCAGTTGTCACAGTCACATTGATTGTACTTGTATACGCACACAAATACACTCAT

>90437_90437_3_TGFB2-WLS_TGFB2_chr1_218536759_ENST00000366929_WLS_chr1_68659910_ENST00000540432_length(amino acids)=653AA_BP=143
MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACE
RERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCD
KIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKC
TFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWY
WRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPI
AVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRF
KFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGMQLPCKSREDCALFVS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TGFB2-WLS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	WLS	chr1:218536759	chr1:68659910	ENST00000262348		0	12	101_232	35.333333333333336	542.0	Wnt proteins
Tgene	WLS	chr1:218536759	chr1:68659910	ENST00000354777		0	12	101_232	35.333333333333336	544.0	Wnt proteins
Tgene	WLS	chr1:218536759	chr1:68659910	ENST00000370976		0	11	101_232	0	451.0	Wnt proteins

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TGFB2-WLS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TGFB2-WLS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source