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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TGFBR1-SEC61B (FusionGDB2 ID:90457)

Fusion Gene Summary for TGFBR1-SEC61B

Fusion gene summary

Fusion gene information	Fusion gene name: TGFBR1-SEC61B
	Fusion gene ID: 90457
		Hgene	Tgene
	Gene symbol	TGFBR1	SEC61B
	Gene ID	7046	10952
	Gene name	transforming growth factor beta receptor 1	SEC61 translocon subunit beta
	Synonyms	AAT5\|ACVRLK4\|ALK-5\|ALK5\|ESS1\|LDS1\|LDS1A\|LDS2A\|MSSE\|SKR4\|TBR-i\|TBRI\|TGFR-1\|tbetaR-I	-
	Cytomap	9q22.33	9q22.33
	Type of gene	protein-coding	protein-coding
	Description	TGF-beta receptor type-1activin A receptor type II-like kinase, 53kDaactivin A receptor type II-like protein kinase of 53kDactivin receptor-like kinase 5mutant transforming growth factor beta receptor Iserine/threonine-protein kinase receptor R4tran	protein transport protein Sec61 subunit betaSEC61 translocon beta subunitSec61 beta subunitSec61 complex, beta subunitprotein translocation complex betaprotein transport protein SEC61 beta subunit
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000374990, ENST00000374994, ENST00000552516, ENST00000550253,	ENST00000481573, ENST00000223641, ENST00000498603,
Fusion gene scores	* DoF score	4 X 4 X 3=48	3 X 2 X 3=18
	# samples	4	3
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TGFBR1 [Title/Abstract] AND SEC61B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TGFBR1(101867584)-SEC61B(101992619), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TGFBR1	GO:0000186	activation of MAPKK activity	18625725
Hgene	TGFBR1	GO:0001837	epithelial to mesenchymal transition	15761148
Hgene	TGFBR1	GO:0006355	regulation of transcription, DNA-templated	14517293
Hgene	TGFBR1	GO:0006468	protein phosphorylation	12015308\|12065756
Hgene	TGFBR1	GO:0007165	signal transduction	14633705
Hgene	TGFBR1	GO:0007179	transforming growth factor beta receptor signaling pathway	9389648\|11157754
Hgene	TGFBR1	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	9311995\|9389648
Hgene	TGFBR1	GO:0018105	peptidyl-serine phosphorylation	15761148
Hgene	TGFBR1	GO:0018107	peptidyl-threonine phosphorylation	19736306
Hgene	TGFBR1	GO:0030307	positive regulation of cell growth	18625725
Hgene	TGFBR1	GO:0030335	positive regulation of cell migration	19736306
Hgene	TGFBR1	GO:0031396	regulation of protein ubiquitination	18758450
Hgene	TGFBR1	GO:0045893	positive regulation of transcription, DNA-templated	9311995\|9389648
Hgene	TGFBR1	GO:0051897	positive regulation of protein kinase B signaling	18625725
Hgene	TGFBR1	GO:0060389	pathway-restricted SMAD protein phosphorylation	11157754\|12015308\|18625725\|19736306
Hgene	TGFBR1	GO:0060391	positive regulation of SMAD protein signal transduction	9389648
Hgene	TGFBR1	GO:0070723	response to cholesterol	17878231
Hgene	TGFBR1	GO:0071560	cellular response to transforming growth factor beta stimulus	19494318
Hgene	TGFBR1	GO:2001235	positive regulation of apoptotic signaling pathway	18758450
Tgene	SEC61B	GO:0030433	ubiquitin-dependent ERAD pathway	8945469

Fusion gene breakpoints across TGFBR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC61B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N9-A4Q4	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+

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Fusion Gene ORF analysis for TGFBR1-SEC61B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000374990	ENST00000481573	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
5CDS-intron	ENST00000374994	ENST00000481573	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
5CDS-intron	ENST00000552516	ENST00000481573	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
In-frame	ENST00000374990	ENST00000223641	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
In-frame	ENST00000374990	ENST00000498603	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
In-frame	ENST00000374994	ENST00000223641	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
In-frame	ENST00000374994	ENST00000498603	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
In-frame	ENST00000552516	ENST00000223641	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
In-frame	ENST00000552516	ENST00000498603	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
intron-3CDS	ENST00000550253	ENST00000223641	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
intron-3CDS	ENST00000550253	ENST00000498603	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+
intron-intron	ENST00000550253	ENST00000481573	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000374994	TGFBR1	chr9	101867584	+	ENST00000498603	SEC61B	chr9	101992619	+	493	214	133	435	100
ENST00000374994	TGFBR1	chr9	101867584	+	ENST00000223641	SEC61B	chr9	101992619	+	493	214	133	435	100
ENST00000374990	TGFBR1	chr9	101867584	+	ENST00000498603	SEC61B	chr9	101992619	+	471	192	111	413	100
ENST00000374990	TGFBR1	chr9	101867584	+	ENST00000223641	SEC61B	chr9	101992619	+	471	192	111	413	100
ENST00000552516	TGFBR1	chr9	101867584	+	ENST00000498603	SEC61B	chr9	101992619	+	432	153	72	374	100
ENST00000552516	TGFBR1	chr9	101867584	+	ENST00000223641	SEC61B	chr9	101992619	+	432	153	72	374	100

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374994	ENST00000498603	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+	0.16512632	0.8348737
ENST00000374994	ENST00000223641	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+	0.16512632	0.8348737
ENST00000374990	ENST00000498603	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+	0.3384838	0.66151625
ENST00000374990	ENST00000223641	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+	0.3384838	0.66151625
ENST00000552516	ENST00000498603	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+	0.2828398	0.71716017
ENST00000552516	ENST00000223641	TGFBR1	chr9	101867584	+	SEC61B	chr9	101992619	+	0.2828398	0.71716017

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Fusion Genomic Features for TGFBR1-SEC61B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TGFBR1	chr9	101867584	+	SEC61B	chr9	101992618	+	2.67E-08	1
TGFBR1	chr9	101867584	+	SEC61B	chr9	101992618	+	2.67E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TGFBR1-SEC61B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:101867584/chr9:101992619)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SEC61B

chr9:101867584

chr9:101992619

ENST00000223641

71_91

97.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374990

175_204

427.0

Domain

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374990

205_495

427.0

Domain

Protein kinase

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374994

175_204

504.0

Domain

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374994

205_495

504.0

Domain

Protein kinase

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000552516

175_204

508.0

Domain

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000552516

205_495

508.0

Domain

Protein kinase

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374990

193_194

427.0

Motif

Note=FKBP1A-binding

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374994

193_194

504.0

Motif

Note=FKBP1A-binding

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000552516

193_194

508.0

Motif

Note=FKBP1A-binding

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374990

211_219

427.0

Nucleotide binding

ATP

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374994

211_219

504.0

Nucleotide binding

ATP

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000552516

211_219

508.0

Nucleotide binding

ATP

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374990

148_503

427.0

Topological domain

Cytoplasmic

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374990

34_126

427.0

Topological domain

Extracellular

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374994

148_503

504.0

Topological domain

Cytoplasmic

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374994

34_126

504.0

Topological domain

Extracellular

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000552516

148_503

508.0

Topological domain

Cytoplasmic

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000552516

34_126

508.0

Topological domain

Extracellular

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374990

127_147

427.0

Transmembrane

Helical

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000374994

127_147

504.0

Transmembrane

Helical

Hgene

TGFBR1

chr9:101867584

chr9:101992619

ENST00000552516

127_147

508.0

Transmembrane

Helical

Tgene

SEC61B

chr9:101867584

chr9:101992619

ENST00000223641

2_70

97.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for TGFBR1-SEC61B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>90457_90457_1_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000374990_SEC61B_chr9_101992619_ENST00000223641_length(transcript)=471nt_BP=192nt
GCGGCGGCTAGGGAGGTGGGGCGAGGCGAGGTTTGCTGGGGTGAGGCAGCGGCGCGGCCGGGCCGGGCCGGGCCACAGGCGGTGGCGGCG
GGACCATGGAGGCGGCGGTCGCTGCTCCGCGTCCCCGGCTGCTCCTCCTCGTGCTGGCGGCGGCGGCGGCGGCGGCGGCGGCGCTGCTCC
CGGGGGCGACGGTGGCCCTGTTCCAGTATTGGTTATGAGTCTTCTGTTCATCGCTTCTGTATTTATGTTGCACATTTGGGGCAAGTACAC
TCGTTCGTAGATTCAGTTACATCCATCTGTCATCTGAAGAAGGAGGAAAAAACCCAACATTTCTTGGACCAAAAGTATAGTGACTATCTG
TTCATGAGAGAAATTTTCTGTAAGCTTGCTGTTTTACAGGGGATTTATCAATAATTGATTTTGAGGAATCAGTTTTTTTCTATGGCTAAT

>90457_90457_1_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000374990_SEC61B_chr9_101992619_ENST00000223641_length(amino acids)=100AA_BP=1
MLRVPGCSSSCWRRRRRRRRRCSRGRRWPCSSIGYESSVHRFCIYVAHLGQVHSFVDSVTSICHLKKEEKTQHFLDQKYSDYLFMREIFC

--------------------------------------------------------------
>90457_90457_2_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000374990_SEC61B_chr9_101992619_ENST00000498603_length(transcript)=471nt_BP=192nt
GCGGCGGCTAGGGAGGTGGGGCGAGGCGAGGTTTGCTGGGGTGAGGCAGCGGCGCGGCCGGGCCGGGCCGGGCCACAGGCGGTGGCGGCG
GGACCATGGAGGCGGCGGTCGCTGCTCCGCGTCCCCGGCTGCTCCTCCTCGTGCTGGCGGCGGCGGCGGCGGCGGCGGCGGCGCTGCTCC
CGGGGGCGACGGTGGCCCTGTTCCAGTATTGGTTATGAGTCTTCTGTTCATCGCTTCTGTATTTATGTTGCACATTTGGGGCAAGTACAC
TCGTTCGTAGATTCAGTTACATCCATCTGTCATCTGAAGAAGGAGGAAAAAACCCAACATTTCTTGGACCAAAAGTATAGTGACTATCTG
TTCATGAGAGAAATTTTCTGTAAGCTTGCTGTTTTACAGGGGATTTATCAATAATTGATTTTGAGGAATCAGTTTTTTTCTATGGCTAAT

>90457_90457_2_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000374990_SEC61B_chr9_101992619_ENST00000498603_length(amino acids)=100AA_BP=1
MLRVPGCSSSCWRRRRRRRRRCSRGRRWPCSSIGYESSVHRFCIYVAHLGQVHSFVDSVTSICHLKKEEKTQHFLDQKYSDYLFMREIFC

--------------------------------------------------------------
>90457_90457_3_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000374994_SEC61B_chr9_101992619_ENST00000223641_length(transcript)=493nt_BP=214nt
AAAGGGCCGGAGCGAGGCCGCCGCGGCGGCTAGGGAGGTGGGGCGAGGCGAGGTTTGCTGGGGTGAGGCAGCGGCGCGGCCGGGCCGGGC
CGGGCCACAGGCGGTGGCGGCGGGACCATGGAGGCGGCGGTCGCTGCTCCGCGTCCCCGGCTGCTCCTCCTCGTGCTGGCGGCGGCGGCG
GCGGCGGCGGCGGCGCTGCTCCCGGGGGCGACGGTGGCCCTGTTCCAGTATTGGTTATGAGTCTTCTGTTCATCGCTTCTGTATTTATGT
TGCACATTTGGGGCAAGTACACTCGTTCGTAGATTCAGTTACATCCATCTGTCATCTGAAGAAGGAGGAAAAAACCCAACATTTCTTGGA
CCAAAAGTATAGTGACTATCTGTTCATGAGAGAAATTTTCTGTAAGCTTGCTGTTTTACAGGGGATTTATCAATAATTGATTTTGAGGAA

>90457_90457_3_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000374994_SEC61B_chr9_101992619_ENST00000223641_length(amino acids)=100AA_BP=1
MLRVPGCSSSCWRRRRRRRRRCSRGRRWPCSSIGYESSVHRFCIYVAHLGQVHSFVDSVTSICHLKKEEKTQHFLDQKYSDYLFMREIFC

--------------------------------------------------------------
>90457_90457_4_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000374994_SEC61B_chr9_101992619_ENST00000498603_length(transcript)=493nt_BP=214nt
AAAGGGCCGGAGCGAGGCCGCCGCGGCGGCTAGGGAGGTGGGGCGAGGCGAGGTTTGCTGGGGTGAGGCAGCGGCGCGGCCGGGCCGGGC
CGGGCCACAGGCGGTGGCGGCGGGACCATGGAGGCGGCGGTCGCTGCTCCGCGTCCCCGGCTGCTCCTCCTCGTGCTGGCGGCGGCGGCG
GCGGCGGCGGCGGCGCTGCTCCCGGGGGCGACGGTGGCCCTGTTCCAGTATTGGTTATGAGTCTTCTGTTCATCGCTTCTGTATTTATGT
TGCACATTTGGGGCAAGTACACTCGTTCGTAGATTCAGTTACATCCATCTGTCATCTGAAGAAGGAGGAAAAAACCCAACATTTCTTGGA
CCAAAAGTATAGTGACTATCTGTTCATGAGAGAAATTTTCTGTAAGCTTGCTGTTTTACAGGGGATTTATCAATAATTGATTTTGAGGAA

>90457_90457_4_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000374994_SEC61B_chr9_101992619_ENST00000498603_length(amino acids)=100AA_BP=1
MLRVPGCSSSCWRRRRRRRRRCSRGRRWPCSSIGYESSVHRFCIYVAHLGQVHSFVDSVTSICHLKKEEKTQHFLDQKYSDYLFMREIFC

--------------------------------------------------------------
>90457_90457_5_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000552516_SEC61B_chr9_101992619_ENST00000223641_length(transcript)=432nt_BP=153nt
GGTGAGGCAGCGGCGCGGCCGGGCCGGGCCGGGCCACAGGCGGTGGCGGCGGGACCATGGAGGCGGCGGTCGCTGCTCCGCGTCCCCGGC
TGCTCCTCCTCGTGCTGGCGGCGGCGGCGGCGGCGGCGGCGGCGCTGCTCCCGGGGGCGACGGTGGCCCTGTTCCAGTATTGGTTATGAG
TCTTCTGTTCATCGCTTCTGTATTTATGTTGCACATTTGGGGCAAGTACACTCGTTCGTAGATTCAGTTACATCCATCTGTCATCTGAAG
AAGGAGGAAAAAACCCAACATTTCTTGGACCAAAAGTATAGTGACTATCTGTTCATGAGAGAAATTTTCTGTAAGCTTGCTGTTTTACAG

>90457_90457_5_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000552516_SEC61B_chr9_101992619_ENST00000223641_length(amino acids)=100AA_BP=1
MLRVPGCSSSCWRRRRRRRRRCSRGRRWPCSSIGYESSVHRFCIYVAHLGQVHSFVDSVTSICHLKKEEKTQHFLDQKYSDYLFMREIFC

--------------------------------------------------------------
>90457_90457_6_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000552516_SEC61B_chr9_101992619_ENST00000498603_length(transcript)=432nt_BP=153nt
GGTGAGGCAGCGGCGCGGCCGGGCCGGGCCGGGCCACAGGCGGTGGCGGCGGGACCATGGAGGCGGCGGTCGCTGCTCCGCGTCCCCGGC
TGCTCCTCCTCGTGCTGGCGGCGGCGGCGGCGGCGGCGGCGGCGCTGCTCCCGGGGGCGACGGTGGCCCTGTTCCAGTATTGGTTATGAG
TCTTCTGTTCATCGCTTCTGTATTTATGTTGCACATTTGGGGCAAGTACACTCGTTCGTAGATTCAGTTACATCCATCTGTCATCTGAAG
AAGGAGGAAAAAACCCAACATTTCTTGGACCAAAAGTATAGTGACTATCTGTTCATGAGAGAAATTTTCTGTAAGCTTGCTGTTTTACAG

>90457_90457_6_TGFBR1-SEC61B_TGFBR1_chr9_101867584_ENST00000552516_SEC61B_chr9_101992619_ENST00000498603_length(amino acids)=100AA_BP=1
MLRVPGCSSSCWRRRRRRRRRCSRGRRWPCSSIGYESSVHRFCIYVAHLGQVHSFVDSVTSICHLKKEEKTQHFLDQKYSDYLFMREIFC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TGFBR1-SEC61B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TGFBR1-SEC61B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TGFBR1-SEC61B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source