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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TGFBR2-CLASP2 (FusionGDB2 ID:90460)

Fusion Gene Summary for TGFBR2-CLASP2

check button Fusion gene summary
Fusion gene informationFusion gene name: TGFBR2-CLASP2
Fusion gene ID: 90460
HgeneTgene
Gene symbol

TGFBR2

CLASP2

Gene ID

7048

23122

Gene nametransforming growth factor beta receptor 2cytoplasmic linker associated protein 2
SynonymsAAT3|FAA3|LDS1B|LDS2|LDS2B|MFS2|RIIC|TAAD2|TBR-ii|TBRII|TGFR-2|TGFbeta-RII-
Cytomap

3p24.1

3p22.3

Type of geneprotein-codingprotein-coding
DescriptionTGF-beta receptor type-2TGF-beta receptor type IIBTGF-beta type II receptortbetaR-IItransforming growth factor beta receptor IItransforming growth factor beta receptor type IICtransforming growth factor, beta receptor II (70/80kDa)transforming growCLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2
Modification date2020032920200313
UniProtAcc.

O75122

Ensembl transtripts involved in fusion geneENST00000295754, ENST00000359013, 
ENST00000307312, ENST00000313350, 
ENST00000333778, ENST00000461133, 
ENST00000480013, ENST00000482896, 
ENST00000487200, ENST00000539981, 
ENST00000359576, ENST00000399362, 
ENST00000468888, 
Fusion gene scores* DoF score9 X 6 X 7=37815 X 10 X 9=1350
# samples 915
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1350*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TGFBR2 [Title/Abstract] AND CLASP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTGFBR2(30715738)-CLASP2(33686395), # samples:1
Anticipated loss of major functional domain due to fusion event.TGFBR2-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TGFBR2-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TGFBR2-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
TGFBR2-CLASP2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
TGFBR2-CLASP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTGFBR2

GO:0006468

protein phosphorylation

12015308

HgeneTGFBR2

GO:0006915

apoptotic process

17471240

HgeneTGFBR2

GO:0007179

transforming growth factor beta receptor signaling pathway

18453574

HgeneTGFBR2

GO:0010718

positive regulation of epithelial to mesenchymal transition

26459119

HgeneTGFBR2

GO:0018105

peptidyl-serine phosphorylation

12015308

HgeneTGFBR2

GO:0018107

peptidyl-threonine phosphorylation

12015308

HgeneTGFBR2

GO:0042493

response to drug

17878231

HgeneTGFBR2

GO:0060389

pathway-restricted SMAD protein phosphorylation

18453574

HgeneTGFBR2

GO:0070723

response to cholesterol

17878231

HgeneTGFBR2

GO:2000563

positive regulation of CD4-positive, alpha-beta T cell proliferation

17164348


check buttonFusion gene breakpoints across TGFBR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLASP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OJTGFBR2chr3

30715738

+CLASP2chr3

33686395

-


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Fusion Gene ORF analysis for TGFBR2-CLASP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000295754ENST00000307312TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000295754ENST00000313350TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000295754ENST00000333778TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000295754ENST00000461133TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000295754ENST00000480013TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000295754ENST00000482896TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000295754ENST00000487200TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000359013ENST00000307312TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000359013ENST00000313350TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000359013ENST00000333778TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000359013ENST00000461133TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000359013ENST00000480013TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000359013ENST00000482896TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
5CDS-5UTRENST00000359013ENST00000487200TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
Frame-shiftENST00000295754ENST00000539981TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
Frame-shiftENST00000359013ENST00000539981TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
In-frameENST00000295754ENST00000359576TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
In-frameENST00000295754ENST00000399362TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
In-frameENST00000295754ENST00000468888TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
In-frameENST00000359013ENST00000359576TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
In-frameENST00000359013ENST00000399362TGFBR2chr3

30715738

+CLASP2chr3

33686395

-
In-frameENST00000359013ENST00000468888TGFBR2chr3

30715738

+CLASP2chr3

33686395

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295754TGFBR2chr330715738+ENST00000468888CLASP2chr333686395-7994177838256071741
ENST00000295754TGFBR2chr330715738+ENST00000399362CLASP2chr333686395-7991177838256041740
ENST00000295754TGFBR2chr330715738+ENST00000359576CLASP2chr333686395-7963177838255801732
ENST00000359013TGFBR2chr330715738+ENST00000468888CLASP2chr333686395-7970175428355831766
ENST00000359013TGFBR2chr330715738+ENST00000399362CLASP2chr333686395-7967175428355801765
ENST00000359013TGFBR2chr330715738+ENST00000359576CLASP2chr333686395-7939175428355561757

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295754ENST00000468888TGFBR2chr330715738+CLASP2chr333686395-0.0004593330.9995407
ENST00000295754ENST00000399362TGFBR2chr330715738+CLASP2chr333686395-0.0004498480.99955016
ENST00000295754ENST00000359576TGFBR2chr330715738+CLASP2chr333686395-0.0003931950.9996068
ENST00000359013ENST00000468888TGFBR2chr330715738+CLASP2chr333686395-0.0004254920.9995745
ENST00000359013ENST00000399362TGFBR2chr330715738+CLASP2chr333686395-0.0004168350.9995832
ENST00000359013ENST00000359576TGFBR2chr330715738+CLASP2chr333686395-0.0003646240.99963534

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Fusion Genomic Features for TGFBR2-CLASP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TGFBR2-CLASP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:30715738/chr3:33686395)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLASP2

O75122

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000295754+57250_258465568.0Nucleotide bindingATP
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000359013+68250_258490593.0Nucleotide bindingATP
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000295754+5723_166465568.0Topological domainExtracellular
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000359013+6823_166490593.0Topological domainExtracellular
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000295754+57167_187465568.0TransmembraneHelical
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000359013+68167_187490593.0TransmembraneHelical
TgeneCLASP2chr3:30715738chr3:33686395ENST000003133500131104_110811432.0Compositional biasNote=Poly-Leu
TgeneCLASP2chr3:30715738chr3:33686395ENST00000313350013310_58711432.0Compositional biasNote=Ser-rich
TgeneCLASP2chr3:30715738chr3:33686395ENST000003133500131017_129411432.0RegionNote=Required for cortical localization
TgeneCLASP2chr3:30715738chr3:33686395ENST0000031335001360_31111432.0RegionTOG 1
TgeneCLASP2chr3:30715738chr3:33686395ENST00000313350013649_88111432.0RegionTOG 2
TgeneCLASP2chr3:30715738chr3:33686395ENST000003133500131054_109111432.0RepeatHEAT 6
TgeneCLASP2chr3:30715738chr3:33686395ENST000003133500131098_113511432.0RepeatHEAT 7
TgeneCLASP2chr3:30715738chr3:33686395ENST000003133500131216_125311432.0RepeatHEAT 8
TgeneCLASP2chr3:30715738chr3:33686395ENST00000313350013173_20811432.0RepeatHEAT 1
TgeneCLASP2chr3:30715738chr3:33686395ENST00000313350013209_24511432.0RepeatHEAT 2
TgeneCLASP2chr3:30715738chr3:33686395ENST00000313350013250_28711432.0RepeatHEAT 3
TgeneCLASP2chr3:30715738chr3:33686395ENST00000313350013710_74711432.0RepeatHEAT 4
TgeneCLASP2chr3:30715738chr3:33686395ENST00000313350013772_80911432.0RepeatHEAT 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000295754+57244_544465568.0DomainProtein kinase
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000359013+68244_544490593.0DomainProtein kinase
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000295754+57188_567465568.0Topological domainCytoplasmic
HgeneTGFBR2chr3:30715738chr3:33686395ENST00000359013+68188_567490593.0Topological domainCytoplasmic


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Fusion Gene Sequence for TGFBR2-CLASP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90460_90460_1_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000295754_CLASP2_chr3_33686395_ENST00000359576_length(transcript)=7963nt_BP=1778nt
GGAGAGGGAGAAGGCTCTCGGGCGGAGAGAGGTCCTGCCCAGCTGTTGGCGAGGAGTTTCCTGTTTCCCCCGCAGCGCTGAGTTGAAGTT
GAGTGAGTCACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGG
CCGCCGGGGGCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGC
CGGCCCGGCGCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCT
ATGACGAGCAGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCAC
GATCCCACCGCACGTTCAGAAGTCGGTTAATAACGACATGATAGTCACTGACAACAACGGTGCAGTCAAGTTTCCACAACTGTGTAAATT
TTGTGATGTGAGATTTTCCACCTGTGACAACCAGAAATCCTGCATGAGCAACTGCAGCATCACCTCCATCTGTGAGAAGCCACAGGAAGT
CTGTGTGGCTGTATGGAGAAAGAATGACGAGAACATAACACTAGAGACAGTTTGCCATGACCCCAAGCTCCCCTACCATGACTTTATTCT
GGAAGATGCTGCTTCTCCAAAGTGCATTATGAAGGAAAAAAAAAAGCCTGGTGAGACTTTCTTCATGTGTTCCTGTAGCTCTGATGAGTG
CAATGACAACATCATCTTCTCAGAAGAATATAACACCAGCAATCCTGACTTGTTGCTAGTCATATTTCAAGTGACAGGCATCAGCCTCCT
GCCACCACTGGGAGTTGCCATATCTGTCATCATCATCTTCTACTGCTACCGCGTTAACCGGCAGCAGAAGCTGAGTTCAACCTGGGAAAC
CGGCAAGACGCGGAAGCTCATGGAGTTCAGCGAGCACTGTGCCATCATCCTGGAAGATGACCGCTCTGACATCAGCTCCACGTGTGCCAA
CAACATCAACCACAACACAGAGCTGCTGCCCATTGAGCTGGACACCCTGGTGGGGAAAGGTCGCTTTGCTGAGGTCTATAAGGCCAAGCT
GAAGCAGAACACTTCAGAGCAGTTTGAGACAGTGGCAGTCAAGATCTTTCCCTATGAGGAGTATGCCTCTTGGAAGACAGAGAAGGACAT
CTTCTCAGACATCAATCTGAAGCATGAGAACATACTCCAGTTCCTGACGGCTGAGGAGCGGAAGACGGAGTTGGGGAAACAATACTGGCT
GATCACCGCCTTCCACGCCAAGGGCAACCTACAGGAGTACCTGACGCGGCATGTCATCAGCTGGGAGGACCTGCGCAAGCTGGGCAGCTC
CCTCGCCCGGGGGATTGCTCACCTCCACAGTGATCACACTCCATGTGGGAGGCCCAAGATGCCCATCGTGCACAGGGACCTCAAGAGCTC
CAATATCCTCGTGAAGAACGACCTAACCTGCTGCCTGTGTGACTTTGGGCTTTCCCTGCGTCTGGACCCTACTCTGTCTGTGGATGACCT
GGCTAACAGTGGGCAGGTGGGAACTGCAAGATACATGGCTCCAGAAGTCCTAGAATCCAGGATGAATTTGGAGAATGTTGAGTCCTTCAA
GCAGACCGATGTCTACTCCATGGCTCTGGTGCTCTGGGAAATGACATCTCGCTGTAATGCAGTGGGAGATAAAAGCTTCGATGATGAAGA
ATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAG
GAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGC
TTTTACAGATGTCCCTTCTATTCAGATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATAAAATCAGGGAAATTTTGTCAGATGATAA
ACATGACTGGGATCAGCGTGCCAATGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAGCTGCACAGTATGATTGCTTTTTTCAACA
TTTACGATTGTTGGATGGAGCACTTAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTAGAGAAGCTTGTATTACTGTAGCCCACCT
TTCAACAGTTTTGGGAAACAAGTTTGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTAATCTCGTCCCCAATAGTGCAAAAGTCAT
GGCAACTTCTGGATGTGCAGCAATCAGATTTATCATTCGGCATACTCATGTACCCAGACTTATACCTTTAATAACAAGCAATTGCACATC
AAAATCAGTTCCCGTGAGGAGACGTTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGCAGACTCATTCATTGGAAAGACATGCAGC
CGTCTTGGTTGAAACTATTAAAAAGGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGGCAAGAAAGACATACATGGGTCTTAGAAA
CCACTTTCCTGGTGAAGCTGAAACATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTCTTCAAACTTACTTAAAGAGTTCTGGCAG
TGTAGCATCTCTTCCACAATCAGACAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCCCTTTTTCTTCCAAATGGTCTACAGCAAA
TCCATCAACTGTGGCTGGAAGAGTATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAAGCCTGCAGCGTTCACGAAGTGACATTGA
TGTGAATGCTGCTGCAGGTGCCAAGGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGCGCTTAGGTGCAGGTGCCCTGAATGCAGG
TTCCTATGCGTCACTAGAGGATACTTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCCGGGTGAGAGCAAAACTTTCAGCACCACT
TGCTGGCATGGGAAATGCCAAGGCAGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTCAATCACAGCCTGGTAGCCGGTCTGGGTC
TCCAGGAAGAGTTCTGACCACAACAGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCCTGGTCAATTCAGCCTCAGCACAAAAAAG
AAGCAAGATACCACGGAGCCAGGGCTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGGCCCGAAGCAGTCGTATTCCTCGACCAAG
TGTGAGTCAAGGATGCAGCCGGGAAGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTCGCTCTTTTCAGCCCCTCGGTCCAGGTTA
TGGGATCAGCCAATCAAGTCGACTGTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAGGTTCTGATGTGGAGGAGGCGGTGGCAGA
TGCCTTGAAAAAACCAGCTCGAAGAAGATATGAATCATATGGAATGCATTCAGATGATGACGCCAACAGCGATGCATCTAGTGCTTGTTC
AGAACGCTCCTATAGTTCTCGAAATGGTAGTATTCCTACATATATGAGGCAGACGGAAGATGTGGCAGAAGTCCTCAATAGATGTGCTAG
TTCCAATTGGTCAGAAAGGAAAGAAGGCCTCCTAGGTCTGCAGAACTTATTAAAAAATCAGAGAACACTAAGTCGAGTTGAACTGAAAAG
ATTATGTGAAATTTTCACAAGAATGTTTGCTGACCCTCATGGCAAGGTATTCAGCATGTTTTTGGAGACTCTAGTGGATTTCATACAAGT
CCACAAAGATGATCTTCAAGATTGGTTGTTTGTACTGCTGACACAACTACTAAAAAAAATGGGTGCTGATTTGCTTGGATCTGTTCAGGC
AAAAGTTCAGAAAGCCCTTGATGTTACAAGAGAGTCTTTTCCAAATGATCTTCAGTTCAATATTCTAATGAGATTTACAGTTGATCAGAC
CCAGACACCAAGCTTAAAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTC
CAGTGAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCT
GATTTCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCT
TCATAATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTG
GTCCAGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGA
AGATATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAG
GGATTCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCA
AACAGCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTC
AGATAGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGA
TCATTCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTAT
GAAACTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGA
GCCTACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGT
CATGAAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAG
TCCAGAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGT
GATAGAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAG
TGTTCGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAG
TAAAATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTA
GTGAAGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTT
TGGAACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTA
ACTTTTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTT
CACATGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAA
AGCTTTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTAT
CATGTCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATAC
ATGTCATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAA
AACTGATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCA
TCTGCCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGC
TTTTTTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGAC
CGTCTTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTT
ACCATGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCT
ACCTCTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAG
CAAATTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGA
TAATTTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTA
TTAGGGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAA
GAGTACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCT
GTAACAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACAT
AACATTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTC
TTGTATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGC
TACATACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGA
TATGTTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAG
AGTGACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTA
CATAATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGT
TGATAAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGC
TACTTAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTA

>90460_90460_1_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000295754_CLASP2_chr3_33686395_ENST00000359576_length(amino acids)=1732AA_BP=465
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRK
NDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ
FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSM
ALVLWEMTSRCNAVGDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSI
QIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNK
FDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIK
KGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGR
VSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTASEDGRVRAKLSAPLAGMGNAK
ADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSR
EASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYESYGMHSDDDANSDASSACSERSYSSR
NGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQD
WLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFINSSETRLAV
SRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSP
TNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKA
SLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYELMKLTQEES
FSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKV
LCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNL

--------------------------------------------------------------
>90460_90460_2_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000295754_CLASP2_chr3_33686395_ENST00000399362_length(transcript)=7991nt_BP=1778nt
GGAGAGGGAGAAGGCTCTCGGGCGGAGAGAGGTCCTGCCCAGCTGTTGGCGAGGAGTTTCCTGTTTCCCCCGCAGCGCTGAGTTGAAGTT
GAGTGAGTCACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGG
CCGCCGGGGGCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGC
CGGCCCGGCGCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCT
ATGACGAGCAGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCAC
GATCCCACCGCACGTTCAGAAGTCGGTTAATAACGACATGATAGTCACTGACAACAACGGTGCAGTCAAGTTTCCACAACTGTGTAAATT
TTGTGATGTGAGATTTTCCACCTGTGACAACCAGAAATCCTGCATGAGCAACTGCAGCATCACCTCCATCTGTGAGAAGCCACAGGAAGT
CTGTGTGGCTGTATGGAGAAAGAATGACGAGAACATAACACTAGAGACAGTTTGCCATGACCCCAAGCTCCCCTACCATGACTTTATTCT
GGAAGATGCTGCTTCTCCAAAGTGCATTATGAAGGAAAAAAAAAAGCCTGGTGAGACTTTCTTCATGTGTTCCTGTAGCTCTGATGAGTG
CAATGACAACATCATCTTCTCAGAAGAATATAACACCAGCAATCCTGACTTGTTGCTAGTCATATTTCAAGTGACAGGCATCAGCCTCCT
GCCACCACTGGGAGTTGCCATATCTGTCATCATCATCTTCTACTGCTACCGCGTTAACCGGCAGCAGAAGCTGAGTTCAACCTGGGAAAC
CGGCAAGACGCGGAAGCTCATGGAGTTCAGCGAGCACTGTGCCATCATCCTGGAAGATGACCGCTCTGACATCAGCTCCACGTGTGCCAA
CAACATCAACCACAACACAGAGCTGCTGCCCATTGAGCTGGACACCCTGGTGGGGAAAGGTCGCTTTGCTGAGGTCTATAAGGCCAAGCT
GAAGCAGAACACTTCAGAGCAGTTTGAGACAGTGGCAGTCAAGATCTTTCCCTATGAGGAGTATGCCTCTTGGAAGACAGAGAAGGACAT
CTTCTCAGACATCAATCTGAAGCATGAGAACATACTCCAGTTCCTGACGGCTGAGGAGCGGAAGACGGAGTTGGGGAAACAATACTGGCT
GATCACCGCCTTCCACGCCAAGGGCAACCTACAGGAGTACCTGACGCGGCATGTCATCAGCTGGGAGGACCTGCGCAAGCTGGGCAGCTC
CCTCGCCCGGGGGATTGCTCACCTCCACAGTGATCACACTCCATGTGGGAGGCCCAAGATGCCCATCGTGCACAGGGACCTCAAGAGCTC
CAATATCCTCGTGAAGAACGACCTAACCTGCTGCCTGTGTGACTTTGGGCTTTCCCTGCGTCTGGACCCTACTCTGTCTGTGGATGACCT
GGCTAACAGTGGGCAGGTGGGAACTGCAAGATACATGGCTCCAGAAGTCCTAGAATCCAGGATGAATTTGGAGAATGTTGAGTCCTTCAA
GCAGACCGATGTCTACTCCATGGCTCTGGTGCTCTGGGAAATGACATCTCGCTGTAATGCAGTGGGAGATAAAAGCTTCGATGATGAAGA
ATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAG
GAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGC
TTTTACAGATGTCCCTTCTATTCAGATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATAAAATCAGGGAAATTTTGTCAGATGATAA
ACATGACTGGGATCAGCGTGCCAATGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAGCTGCACAGTATGATTGCTTTTTTCAACA
TTTACGATTGTTGGATGGAGCACTTAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTAGAGAAGCTTGTATTACTGTAGCCCACCT
TTCAACAGTTTTGGGAAACAAGTTTGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTAATCTCGTCCCCAATAGTGCAAAAGTCAT
GGCAACTTCTGGATGTGCAGCAATCAGATTTATCATTCGGCATACTCATGTACCCAGACTTATACCTTTAATAACAAGCAATTGCACATC
AAAATCAGTTCCCGTGAGGAGACGTTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGCAGACTCATTCATTGGAAAGACATGCAGC
CGTCTTGGTTGAAACTATTAAAAAGGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGGCAAGAAAGACATACATGGGTCTTAGAAA
CCACTTTCCTGGTGAAGCTGAAACATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTCTTCAAACTTACTTAAAGAGTTCTGGCAG
TGTAGCATCTCTTCCACAATCAGACAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCCCTTTTTCTTCCAAATGGTCTACAGCAAA
TCCATCAACTGTGGCTGGAAGAGTATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAAGCCTGCAGCGTTCACGAAGTGACATTGA
TGTGAATGCTGCTGCAGGTGCCAAGGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGCGCTTAGGTGCAGGTGCCCTGAATGCAGG
TTCCTATGCGTCACTAGAGGATACTTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCCGGGTGAGAGCAAAACTTTCAGCACCACT
TGCTGGCATGGGAAATGCCAAGGCAGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTCAATCACAGCCTGGTAGCCGGTCTGGGTC
TCCAGGAAGAGTTCTGACCACAACAGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCCTGGTCAATTCAGCCTCAGCACAAAAAAG
AAGCAAGATACCACGGAGCCAGGGCTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGGCCCGAAGCAGTCGTATTCCTCGACCAAG
TGTGAGTCAAGGATGCAGCCGGGAAGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTCGCTCTTTTCAGCCCCTCGGTCCAGGTTA
TGGGATCAGCCAATCAAGTCGACTGTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAGGTTCTGATGTGGAGGAGGCGGTGGCAGA
TGCCTTGCTCTTAGGAGACATACGGACTAAGAAAAAACCAGCTCGAAGAAGATATGAATCATATGGAATGCATTCAGATGATGACGCCAA
CAGCGATGCATCTAGTGCTTGTTCAGAACGCTCCTATAGTTCTCGAAATGGTAGTATTCCTACATATATGAGGCAGACGGAAGATGTGGC
AGAAGTCCTCAATAGATGTGCTAGTTCCAATTGGTCAGAAAGGAAAGAAGGCCTCCTAGGTCTGCAGAACTTATTAAAAAATCAGAGAAC
ACTAAGTCGAGTTGAACTGAAAAGATTATGTGAAATTTTCACAAGAATGTTTGCTGACCCTCATGGCAAGGTATTCAGCATGTTTTTGGA
GACTCTAGTGGATTTCATACAAGTCCACAAAGATGATCTTCAAGATTGGTTGTTTGTACTGCTGACACAACTACTAAAAAAAATGGGTGC
TGATTTGCTTGGATCTGTTCAGGCAAAAGTTCAGAAAGCCCTTGATGTTACAAGAGAGTCTTTTCCAAATGATCTTCAGTTCAATATTCT
AATGAGATTTACAGTTGATCAGACCCAGACACCAAGCTTAAAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGAT
GGATCCAGGAGATTTTATAAATTCCAGTGAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGT
TCGGAAGGCAGCACAGTCAGTGCTGATTTCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTT
TCAGGATGGTGCTACCAAGCTTCTTCATAATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACC
AACACCACGATCACCAGCTAACTGGTCCAGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTA
TGACACAGAAAATATGAACTCTGAAGATATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGA
AGATATGAATGAGCCATTGAAAAGGGATTCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGG
AGGTGATGCTACTGACTCAAGTCAAACAGCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCG
AGACTATAATCCATATAACTATTCAGATAGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCA
GTTTCCTGACGATCTTTCCCTAGATCATTCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAG
AAAAATTGCCCTCTATGAACTTATGAAACTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATT
GCTTGAAACGCTTGGAGATAAAGAGCCTACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATT
TAAAAACTATGCAGAATTGACTGTCATGAAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGC
ATCAGTGTTGGCCACTTCAATTAGTCCAGAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGC
TGCAATCAAAATGCAAACAAAAGTGATAGAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACA
GGGTTATGATAATTCAGAGAGCAGTGTTCGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACC
ACATCTCAGTCAACTTACTGGCAGTAAAATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCAC
TACTGATGTTTCTGGACAAAGTTAGTGAAGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGA
AAGGAAGTTCTCAAACACATCCTTTGGAACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAG
AGGACTATCCTCAGTCTGCATGTAACTTTTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGT
AATTTTTAATTTAATTCATCATTTCACATGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAA
TGCTGGTTAAACAGGAATGCTTAAAGCTTTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATT
GCTACTTTGAGTTTTGTTTCGTATCATGTCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGG
ACTCCGTTTGTGTGATGGTGATACATGTCATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATG
TTACAGAATCAGCCAGTTCTGTAAAACTGATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATC
CCTTAAGAAAGCTGCACCAAATCATCTGCCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGT
TTATATCTTTGTTGTGAATGATGCTTTTTTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAA
ATCAAGTGCGTGTGTGTCCTTGACCGTCTTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTA
AATGGTGGAACCTGGTTTCCTTTTACCATGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCT
TTGTATAATGGGCTCAAATTCTCTACCTCTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAA
GGGTGATTTTCTGTTACTTTTTAGCAAATTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCA
GTTTTGGTGAAAGGCTAAATTAGATAATTTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAA
TTTGATTGAAAAGGCAAATAGCTATTAGGGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAA
ATATATGTAAAGAATTTAAGACAAGAGTACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTT
TCTCTATATCCTCTCCCTCTACCTGTAACAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCA
TATACTGGCAATAAAACTGTACATAACATTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCA
GTTTTATTTTAACTTTAGACGGTCTTGTATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAG
CTACCACAATCAAAGGTATATAGCTACATACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCT
CAGTAGCATTTTATGACCTTTGGATATGTTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTT
TAACTACTGTTGACAACCAAGTAGAGTGACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCA
GGCACTCAAGAAATGAATTAACTACATAATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTG
TGTTTACAATTTTATAATCTCAGTTGATAAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTCATT
CCAGAAACATACTGAGATGTCAGCTACTTAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAA

>90460_90460_2_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000295754_CLASP2_chr3_33686395_ENST00000399362_length(amino acids)=1740AA_BP=465
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRK
NDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ
FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSM
ALVLWEMTSRCNAVGDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSI
QIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNK
FDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIK
KGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGR
VSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTASEDGRVRAKLSAPLAGMGNAK
ADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSR
EASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRYESYGMHSDDDANSDASSAC
SERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQ
VHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFIN
SSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPAN
WSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDSS
QTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYEL
MKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSI
SPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTG

--------------------------------------------------------------
>90460_90460_3_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000295754_CLASP2_chr3_33686395_ENST00000468888_length(transcript)=7994nt_BP=1778nt
GGAGAGGGAGAAGGCTCTCGGGCGGAGAGAGGTCCTGCCCAGCTGTTGGCGAGGAGTTTCCTGTTTCCCCCGCAGCGCTGAGTTGAAGTT
GAGTGAGTCACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGG
CCGCCGGGGGCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGC
CGGCCCGGCGCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCT
ATGACGAGCAGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCAC
GATCCCACCGCACGTTCAGAAGTCGGTTAATAACGACATGATAGTCACTGACAACAACGGTGCAGTCAAGTTTCCACAACTGTGTAAATT
TTGTGATGTGAGATTTTCCACCTGTGACAACCAGAAATCCTGCATGAGCAACTGCAGCATCACCTCCATCTGTGAGAAGCCACAGGAAGT
CTGTGTGGCTGTATGGAGAAAGAATGACGAGAACATAACACTAGAGACAGTTTGCCATGACCCCAAGCTCCCCTACCATGACTTTATTCT
GGAAGATGCTGCTTCTCCAAAGTGCATTATGAAGGAAAAAAAAAAGCCTGGTGAGACTTTCTTCATGTGTTCCTGTAGCTCTGATGAGTG
CAATGACAACATCATCTTCTCAGAAGAATATAACACCAGCAATCCTGACTTGTTGCTAGTCATATTTCAAGTGACAGGCATCAGCCTCCT
GCCACCACTGGGAGTTGCCATATCTGTCATCATCATCTTCTACTGCTACCGCGTTAACCGGCAGCAGAAGCTGAGTTCAACCTGGGAAAC
CGGCAAGACGCGGAAGCTCATGGAGTTCAGCGAGCACTGTGCCATCATCCTGGAAGATGACCGCTCTGACATCAGCTCCACGTGTGCCAA
CAACATCAACCACAACACAGAGCTGCTGCCCATTGAGCTGGACACCCTGGTGGGGAAAGGTCGCTTTGCTGAGGTCTATAAGGCCAAGCT
GAAGCAGAACACTTCAGAGCAGTTTGAGACAGTGGCAGTCAAGATCTTTCCCTATGAGGAGTATGCCTCTTGGAAGACAGAGAAGGACAT
CTTCTCAGACATCAATCTGAAGCATGAGAACATACTCCAGTTCCTGACGGCTGAGGAGCGGAAGACGGAGTTGGGGAAACAATACTGGCT
GATCACCGCCTTCCACGCCAAGGGCAACCTACAGGAGTACCTGACGCGGCATGTCATCAGCTGGGAGGACCTGCGCAAGCTGGGCAGCTC
CCTCGCCCGGGGGATTGCTCACCTCCACAGTGATCACACTCCATGTGGGAGGCCCAAGATGCCCATCGTGCACAGGGACCTCAAGAGCTC
CAATATCCTCGTGAAGAACGACCTAACCTGCTGCCTGTGTGACTTTGGGCTTTCCCTGCGTCTGGACCCTACTCTGTCTGTGGATGACCT
GGCTAACAGTGGGCAGGTGGGAACTGCAAGATACATGGCTCCAGAAGTCCTAGAATCCAGGATGAATTTGGAGAATGTTGAGTCCTTCAA
GCAGACCGATGTCTACTCCATGGCTCTGGTGCTCTGGGAAATGACATCTCGCTGTAATGCAGTGGGAGATAAAAGCTTCGATGATGAAGA
ATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAG
GAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGCAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAA
AGCTTTTACAGATGTCCCTTCTATTCAGATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATAAAATCAGGGAAATTTTGTCAGATGA
TAAACATGACTGGGATCAGCGTGCCAATGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAGCTGCACAGTATGATTGCTTTTTTCA
ACATTTACGATTGTTGGATGGAGCACTTAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTAGAGAAGCTTGTATTACTGTAGCCCA
CCTTTCAACAGTTTTGGGAAACAAGTTTGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTAATCTCGTCCCCAATAGTGCAAAAGT
CATGGCAACTTCTGGATGTGCAGCAATCAGATTTATCATTCGGCATACTCATGTACCCAGACTTATACCTTTAATAACAAGCAATTGCAC
ATCAAAATCAGTTCCCGTGAGGAGACGTTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGCAGACTCATTCATTGGAAAGACATGC
AGCCGTCTTGGTTGAAACTATTAAAAAGGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGGCAAGAAAGACATACATGGGTCTTAG
AAACCACTTTCCTGGTGAAGCTGAAACATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTCTTCAAACTTACTTAAAGAGTTCTGG
CAGTGTAGCATCTCTTCCACAATCAGACAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCCCTTTTTCTTCCAAATGGTCTACAGC
AAATCCATCAACTGTGGCTGGAAGAGTATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAAGCCTGCAGCGTTCACGAAGTGACAT
TGATGTGAATGCTGCTGCAGGTGCCAAGGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGCGCTTAGGTGCAGGTGCCCTGAATGC
AGGTTCCTATGCGTCACTAGAGGATACTTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCCGGGTGAGAGCAAAACTTTCAGCACC
ACTTGCTGGCATGGGAAATGCCAAGGCAGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTCAATCACAGCCTGGTAGCCGGTCTGG
GTCTCCAGGAAGAGTTCTGACCACAACAGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCCTGGTCAATTCAGCCTCAGCACAAAA
AAGAAGCAAGATACCACGGAGCCAGGGCTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGGCCCGAAGCAGTCGTATTCCTCGACC
AAGTGTGAGTCAAGGATGCAGCCGGGAAGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTCGCTCTTTTCAGCCCCTCGGTCCAGG
TTATGGGATCAGCCAATCAAGTCGACTGTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAGGTTCTGATGTGGAGGAGGCGGTGGC
AGATGCCTTGCTCTTAGGAGACATACGGACTAAGAAAAAACCAGCTCGAAGAAGATATGAATCATATGGAATGCATTCAGATGATGACGC
CAACAGCGATGCATCTAGTGCTTGTTCAGAACGCTCCTATAGTTCTCGAAATGGTAGTATTCCTACATATATGAGGCAGACGGAAGATGT
GGCAGAAGTCCTCAATAGATGTGCTAGTTCCAATTGGTCAGAAAGGAAAGAAGGCCTCCTAGGTCTGCAGAACTTATTAAAAAATCAGAG
AACACTAAGTCGAGTTGAACTGAAAAGATTATGTGAAATTTTCACAAGAATGTTTGCTGACCCTCATGGCAAGGTATTCAGCATGTTTTT
GGAGACTCTAGTGGATTTCATACAAGTCCACAAAGATGATCTTCAAGATTGGTTGTTTGTACTGCTGACACAACTACTAAAAAAAATGGG
TGCTGATTTGCTTGGATCTGTTCAGGCAAAAGTTCAGAAAGCCCTTGATGTTACAAGAGAGTCTTTTCCAAATGATCTTCAGTTCAATAT
TCTAATGAGATTTACAGTTGATCAGACCCAGACACCAAGCTTAAAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACA
GATGGATCCAGGAGATTTTATAAATTCCAGTGAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGA
TGTTCGGAAGGCAGCACAGTCAGTGCTGATTTCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAAC
TTTTCAGGATGGTGCTACCAAGCTTCTTCATAATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAG
ACCAACACCACGATCACCAGCTAACTGGTCCAGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGA
TTATGACACAGAAAATATGAACTCTGAAGATATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCA
AGAAGATATGAATGAGCCATTGAAAAGGGATTCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGC
AGGAGGTGATGCTACTGACTCAAGTCAAACAGCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTC
TCGAGACTATAATCCATATAACTATTCAGATAGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGA
CCAGTTTCCTGACGATCTTTCCCTAGATCATTCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGA
AAGAAAAATTGCCCTCTATGAACTTATGAAACTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTT
ATTGCTTGAAACGCTTGGAGATAAAGAGCCTACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAG
ATTTAAAAACTATGCAGAATTGACTGTCATGAAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGC
GGCATCAGTGTTGGCCACTTCAATTAGTCCAGAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCT
GGCTGCAATCAAAATGCAAACAAAAGTGATAGAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAAT
ACAGGGTTATGATAATTCAGAGAGCAGTGTTCGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAA
ACCACATCTCAGTCAACTTACTGGCAGTAAAATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCC
CACTACTGATGTTTCTGGACAAAGTTAGTGAAGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAA
TGAAAGGAAGTTCTCAAACACATCCTTTGGAACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAA
CAGAGGACTATCCTCAGTCTGCATGTAACTTTTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAA
AGTAATTTTTAATTTAATTCATCATTTCACATGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTT
AAATGCTGGTTAAACAGGAATGCTTAAAGCTTTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTT
ATTGCTACTTTGAGTTTTGTTTCGTATCATGTCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGC
TGGACTCCGTTTGTGTGATGGTGATACATGTCATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAG
ATGTTACAGAATCAGCCAGTTCTGTAAAACTGATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATG
ATCCCTTAAGAAAGCTGCACCAAATCATCTGCCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTT
TGTTTATATCTTTGTTGTGAATGATGCTTTTTTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAA
AAAATCAAGTGCGTGTGTGTCCTTGACCGTCTTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCT
TTAAATGGTGGAACCTGGTTTCCTTTTACCATGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTG
TCTTTGTATAATGGGCTCAAATTCTCTACCTCTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTT
AAAGGGTGATTTTCTGTTACTTTTTAGCAAATTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTA
CCAGTTTTGGTGAAAGGCTAAATTAGATAATTTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGT
GAATTTGATTGAAAAGGCAAATAGCTATTAGGGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTA
GAAATATATGTAAAGAATTTAAGACAAGAGTACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAA
GTTTCTCTATATCCTCTCCCTCTACCTGTAACAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGT
GCATATACTGGCAATAAAACTGTACATAACATTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCAC
TCAGTTTTATTTTAACTTTAGACGGTCTTGTATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTG
TAGCTACCACAATCAAAGGTATATAGCTACATACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCT
TCTCAGTAGCATTTTATGACCTTTGGATATGTTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTG
CTTTAACTACTGTTGACAACCAAGTAGAGTGACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAG
GCAGGCACTCAAGAAATGAATTAACTACATAATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAA
TTGTGTTTACAATTTTATAATCTCAGTTGATAAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTC
ATTCCAGAAACATACTGAGATGTCAGCTACTTAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAAT

>90460_90460_3_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000295754_CLASP2_chr3_33686395_ENST00000468888_length(amino acids)=1741AA_BP=465
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRK
NDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAI
SVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQ
FETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSM
ALVLWEMTSRCNAVGDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGAGASKEGGAGAVDEDDFIKAFTDVPS
IQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGN
KFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETI
KKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAG
RVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKLDGTASEDGRVRAKLSAPLAGMGNA
KADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCS
REASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRYESYGMHSDDDANSDASSA
CSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADPHGKVFSMFLETLVDFI
QVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPGDFI
NSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPA
NWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCGGPGMSDPRAGGDATDS
SQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERVEERKIALYE
LMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATS
ISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLT

--------------------------------------------------------------
>90460_90460_4_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000359013_CLASP2_chr3_33686395_ENST00000359576_length(transcript)=7939nt_BP=1754nt
ACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGGCCGCCGGGG
GCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGCCGGCCCGGC
GCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCTATGACGAGC
AGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACC
GCACGTTCAGAAGTCGGATGTGGAAATGGAGGCCCAGAAAGATGAAATCATCTGCCCCAGCTGTAATAGGACTGCCCATCCACTGAGACA
TATTAATAACGACATGATAGTCACTGACAACAACGGTGCAGTCAAGTTTCCACAACTGTGTAAATTTTGTGATGTGAGATTTTCCACCTG
TGACAACCAGAAATCCTGCATGAGCAACTGCAGCATCACCTCCATCTGTGAGAAGCCACAGGAAGTCTGTGTGGCTGTATGGAGAAAGAA
TGACGAGAACATAACACTAGAGACAGTTTGCCATGACCCCAAGCTCCCCTACCATGACTTTATTCTGGAAGATGCTGCTTCTCCAAAGTG
CATTATGAAGGAAAAAAAAAAGCCTGGTGAGACTTTCTTCATGTGTTCCTGTAGCTCTGATGAGTGCAATGACAACATCATCTTCTCAGA
AGAATATAACACCAGCAATCCTGACTTGTTGCTAGTCATATTTCAAGTGACAGGCATCAGCCTCCTGCCACCACTGGGAGTTGCCATATC
TGTCATCATCATCTTCTACTGCTACCGCGTTAACCGGCAGCAGAAGCTGAGTTCAACCTGGGAAACCGGCAAGACGCGGAAGCTCATGGA
GTTCAGCGAGCACTGTGCCATCATCCTGGAAGATGACCGCTCTGACATCAGCTCCACGTGTGCCAACAACATCAACCACAACACAGAGCT
GCTGCCCATTGAGCTGGACACCCTGGTGGGGAAAGGTCGCTTTGCTGAGGTCTATAAGGCCAAGCTGAAGCAGAACACTTCAGAGCAGTT
TGAGACAGTGGCAGTCAAGATCTTTCCCTATGAGGAGTATGCCTCTTGGAAGACAGAGAAGGACATCTTCTCAGACATCAATCTGAAGCA
TGAGAACATACTCCAGTTCCTGACGGCTGAGGAGCGGAAGACGGAGTTGGGGAAACAATACTGGCTGATCACCGCCTTCCACGCCAAGGG
CAACCTACAGGAGTACCTGACGCGGCATGTCATCAGCTGGGAGGACCTGCGCAAGCTGGGCAGCTCCCTCGCCCGGGGGATTGCTCACCT
CCACAGTGATCACACTCCATGTGGGAGGCCCAAGATGCCCATCGTGCACAGGGACCTCAAGAGCTCCAATATCCTCGTGAAGAACGACCT
AACCTGCTGCCTGTGTGACTTTGGGCTTTCCCTGCGTCTGGACCCTACTCTGTCTGTGGATGACCTGGCTAACAGTGGGCAGGTGGGAAC
TGCAAGATACATGGCTCCAGAAGTCCTAGAATCCAGGATGAATTTGGAGAATGTTGAGTCCTTCAAGCAGACCGATGTCTACTCCATGGC
TCTGGTGCTCTGGGAAATGACATCTCGCTGTAATGCAGTGGGAGATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATC
ATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCC
TAAGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCA
GATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATAAAATCAGGGAAATTTTGTCAGATGATAAACATGACTGGGATCAGCGTGCCAA
TGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAGCTGCACAGTATGATTGCTTTTTTCAACATTTACGATTGTTGGATGGAGCACT
TAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTAGAGAAGCTTGTATTACTGTAGCCCACCTTTCAACAGTTTTGGGAAACAAGTT
TGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTAATCTCGTCCCCAATAGTGCAAAAGTCATGGCAACTTCTGGATGTGCAGCAAT
CAGATTTATCATTCGGCATACTCATGTACCCAGACTTATACCTTTAATAACAAGCAATTGCACATCAAAATCAGTTCCCGTGAGGAGACG
TTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGCAGACTCATTCATTGGAAAGACATGCAGCCGTCTTGGTTGAAACTATTAAAAA
GGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGGCAAGAAAGACATACATGGGTCTTAGAAACCACTTTCCTGGTGAAGCTGAAAC
ATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTCTTCAAACTTACTTAAAGAGTTCTGGCAGTGTAGCATCTCTTCCACAATCAGA
CAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCCCTTTTTCTTCCAAATGGTCTACAGCAAATCCATCAACTGTGGCTGGAAGAGT
ATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAAGCCTGCAGCGTTCACGAAGTGACATTGATGTGAATGCTGCTGCAGGTGCCAA
GGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGCGCTTAGGTGCAGGTGCCCTGAATGCAGGTTCCTATGCGTCACTAGAGGATAC
TTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCCGGGTGAGAGCAAAACTTTCAGCACCACTTGCTGGCATGGGAAATGCCAAGGC
AGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTCAATCACAGCCTGGTAGCCGGTCTGGGTCTCCAGGAAGAGTTCTGACCACAAC
AGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCCTGGTCAATTCAGCCTCAGCACAAAAAAGAAGCAAGATACCACGGAGCCAGGG
CTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGGCCCGAAGCAGTCGTATTCCTCGACCAAGTGTGAGTCAAGGATGCAGCCGGGA
AGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTCGCTCTTTTCAGCCCCTCGGTCCAGGTTATGGGATCAGCCAATCAAGTCGACT
GTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAGGTTCTGATGTGGAGGAGGCGGTGGCAGATGCCTTGAAAAAACCAGCTCGAAG
AAGATATGAATCATATGGAATGCATTCAGATGATGACGCCAACAGCGATGCATCTAGTGCTTGTTCAGAACGCTCCTATAGTTCTCGAAA
TGGTAGTATTCCTACATATATGAGGCAGACGGAAGATGTGGCAGAAGTCCTCAATAGATGTGCTAGTTCCAATTGGTCAGAAAGGAAAGA
AGGCCTCCTAGGTCTGCAGAACTTATTAAAAAATCAGAGAACACTAAGTCGAGTTGAACTGAAAAGATTATGTGAAATTTTCACAAGAAT
GTTTGCTGACCCTCATGGCAAGGTATTCAGCATGTTTTTGGAGACTCTAGTGGATTTCATACAAGTCCACAAAGATGATCTTCAAGATTG
GTTGTTTGTACTGCTGACACAACTACTAAAAAAAATGGGTGCTGATTTGCTTGGATCTGTTCAGGCAAAAGTTCAGAAAGCCCTTGATGT
TACAAGAGAGTCTTTTCCAAATGATCTTCAGTTCAATATTCTAATGAGATTTACAGTTGATCAGACCCAGACACCAAGCTTAAAGGTGAA
GGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTCCAGTGAAACTCGCCTAGCAGTGTC
TCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCTGATTTCATTATTTGAACTCAATAC
CCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCTTCATAATCACCTTCGAAACACTGG
CAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTGGTCCAGTCCTCTTACTTCTCCTAC
CAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGAAGATATTTATAGCTCTCTTAGAGG
TGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAGGGATTCTAAAAAAGATGATGGCGA
TTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCAAACAGCTCTTGATAATAAAGCTTC
ATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTCAGATAGCATCAGTCCCTTCAACAA
GTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGATCATTCTGACCTAGTTGCAGAGTT
GTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTATGAAACTGACACAGGAAGAATCTTT
TAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGAGCCTACAATCAGGGCTTTGGCATT
AAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGTCATGAAAACATTGGAAGCACATAA
AGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAGTCCAGAGCAGTGCATCAAAGTGCT
TTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGTGATAGAGAGAGTGTCCAAGGAAAC
CCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAGTGTTCGGAAAGCTTGTGTCTTCTG
CCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAGTAAAATGAAGCTACTGAATCTTTA
CATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTAGTGAAGCTCATCACAGCGAACCAG
GTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTTTGGAACTTACTATTGTTTCCCAGT
TTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTAACTTTTATGATAGTTATTCCAAAT
TCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTTCACATGTTTGTACTTTGTCTTCCC
ATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAAAGCTTTAAAAGTTTAACAGTCTAA
AACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTATCATGTCCTATGCTAGAAATATTTA
AATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATACATGTCATTAGTTGCAACTTCTTTG
GGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAAAACTGATATTGTCTATTGGTTATT
GATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCATCTGCCTGTTTTTTCTTGATACTT
ACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGCTTTTTTGTATTTATTAATATCAAA
TTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGACCGTCTTCTGTTTCTCACGTAATAA
ACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTTACCATGAAATTGTCTTACTTGAAA
ATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCTACCTCTTCAGGGCTAATACTTTTA
ACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAGCAAATTTTTTTAATCACCTCTTGC
TACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGATAATTTGGAACCAGGATACTAATG
ATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTATTAGGGAAGCAGTTTGCCATTGTT
GCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAAGAGTACTGAATGGATGATTTGTCA
TAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCTGTAACAATTTTGTTTTCTACTGTT
AATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACATAACATTACTTGAAAAAGTTAATAA
TGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTCTTGTATCAGTGGTGGTCTCTTGAA
TTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGCTACATACGCATGTATATATTACAG
CTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGATATGTTTGTAATCATTTCGAATCA
AAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAGAGTGACTTAAGCTGAACAGTAACT
AACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTACATAATGGAAAAGTATGGTTTAAT
GTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGTTGATAAGACTATAAGAAAGCTGAT
TATTTAAATCACTATATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGCTACTTAAAAATGGTCACAAAAAGC
TACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTACTGCACTGCTGAGAACTAATTAAA

>90460_90460_4_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000359013_CLASP2_chr3_33686395_ENST00000359576_length(amino acids)=1757AA_BP=490
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQK
SCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT
SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE
LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE
YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM
APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGG
ASKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSA
KDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEF
LDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSS
SSQESLNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKL
DGTASEDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSRE
ASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALKKPARRRYES
YGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEIFTRMFADP
HGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPSLKVKVAIL
KYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQ
SSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKKDDGDSMCG
GPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKEL
SNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTLEAHKDPHK
EVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKACVFCLVAV

--------------------------------------------------------------
>90460_90460_5_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000359013_CLASP2_chr3_33686395_ENST00000399362_length(transcript)=7967nt_BP=1754nt
ACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGGCCGCCGGGG
GCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGCCGGCCCGGC
GCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCTATGACGAGC
AGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACC
GCACGTTCAGAAGTCGGATGTGGAAATGGAGGCCCAGAAAGATGAAATCATCTGCCCCAGCTGTAATAGGACTGCCCATCCACTGAGACA
TATTAATAACGACATGATAGTCACTGACAACAACGGTGCAGTCAAGTTTCCACAACTGTGTAAATTTTGTGATGTGAGATTTTCCACCTG
TGACAACCAGAAATCCTGCATGAGCAACTGCAGCATCACCTCCATCTGTGAGAAGCCACAGGAAGTCTGTGTGGCTGTATGGAGAAAGAA
TGACGAGAACATAACACTAGAGACAGTTTGCCATGACCCCAAGCTCCCCTACCATGACTTTATTCTGGAAGATGCTGCTTCTCCAAAGTG
CATTATGAAGGAAAAAAAAAAGCCTGGTGAGACTTTCTTCATGTGTTCCTGTAGCTCTGATGAGTGCAATGACAACATCATCTTCTCAGA
AGAATATAACACCAGCAATCCTGACTTGTTGCTAGTCATATTTCAAGTGACAGGCATCAGCCTCCTGCCACCACTGGGAGTTGCCATATC
TGTCATCATCATCTTCTACTGCTACCGCGTTAACCGGCAGCAGAAGCTGAGTTCAACCTGGGAAACCGGCAAGACGCGGAAGCTCATGGA
GTTCAGCGAGCACTGTGCCATCATCCTGGAAGATGACCGCTCTGACATCAGCTCCACGTGTGCCAACAACATCAACCACAACACAGAGCT
GCTGCCCATTGAGCTGGACACCCTGGTGGGGAAAGGTCGCTTTGCTGAGGTCTATAAGGCCAAGCTGAAGCAGAACACTTCAGAGCAGTT
TGAGACAGTGGCAGTCAAGATCTTTCCCTATGAGGAGTATGCCTCTTGGAAGACAGAGAAGGACATCTTCTCAGACATCAATCTGAAGCA
TGAGAACATACTCCAGTTCCTGACGGCTGAGGAGCGGAAGACGGAGTTGGGGAAACAATACTGGCTGATCACCGCCTTCCACGCCAAGGG
CAACCTACAGGAGTACCTGACGCGGCATGTCATCAGCTGGGAGGACCTGCGCAAGCTGGGCAGCTCCCTCGCCCGGGGGATTGCTCACCT
CCACAGTGATCACACTCCATGTGGGAGGCCCAAGATGCCCATCGTGCACAGGGACCTCAAGAGCTCCAATATCCTCGTGAAGAACGACCT
AACCTGCTGCCTGTGTGACTTTGGGCTTTCCCTGCGTCTGGACCCTACTCTGTCTGTGGATGACCTGGCTAACAGTGGGCAGGTGGGAAC
TGCAAGATACATGGCTCCAGAAGTCCTAGAATCCAGGATGAATTTGGAGAATGTTGAGTCCTTCAAGCAGACCGATGTCTACTCCATGGC
TCTGGTGCTCTGGGAAATGACATCTCGCTGTAATGCAGTGGGAGATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATC
ATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCC
TAAGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCA
GATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATAAAATCAGGGAAATTTTGTCAGATGATAAACATGACTGGGATCAGCGTGCCAA
TGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAGCTGCACAGTATGATTGCTTTTTTCAACATTTACGATTGTTGGATGGAGCACT
TAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTAGAGAAGCTTGTATTACTGTAGCCCACCTTTCAACAGTTTTGGGAAACAAGTT
TGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTAATCTCGTCCCCAATAGTGCAAAAGTCATGGCAACTTCTGGATGTGCAGCAAT
CAGATTTATCATTCGGCATACTCATGTACCCAGACTTATACCTTTAATAACAAGCAATTGCACATCAAAATCAGTTCCCGTGAGGAGACG
TTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGCAGACTCATTCATTGGAAAGACATGCAGCCGTCTTGGTTGAAACTATTAAAAA
GGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGGCAAGAAAGACATACATGGGTCTTAGAAACCACTTTCCTGGTGAAGCTGAAAC
ATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTCTTCAAACTTACTTAAAGAGTTCTGGCAGTGTAGCATCTCTTCCACAATCAGA
CAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCCCTTTTTCTTCCAAATGGTCTACAGCAAATCCATCAACTGTGGCTGGAAGAGT
ATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAAGCCTGCAGCGTTCACGAAGTGACATTGATGTGAATGCTGCTGCAGGTGCCAA
GGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGCGCTTAGGTGCAGGTGCCCTGAATGCAGGTTCCTATGCGTCACTAGAGGATAC
TTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCCGGGTGAGAGCAAAACTTTCAGCACCACTTGCTGGCATGGGAAATGCCAAGGC
AGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTCAATCACAGCCTGGTAGCCGGTCTGGGTCTCCAGGAAGAGTTCTGACCACAAC
AGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCCTGGTCAATTCAGCCTCAGCACAAAAAAGAAGCAAGATACCACGGAGCCAGGG
CTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGGCCCGAAGCAGTCGTATTCCTCGACCAAGTGTGAGTCAAGGATGCAGCCGGGA
AGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTCGCTCTTTTCAGCCCCTCGGTCCAGGTTATGGGATCAGCCAATCAAGTCGACT
GTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAGGTTCTGATGTGGAGGAGGCGGTGGCAGATGCCTTGCTCTTAGGAGACATACG
GACTAAGAAAAAACCAGCTCGAAGAAGATATGAATCATATGGAATGCATTCAGATGATGACGCCAACAGCGATGCATCTAGTGCTTGTTC
AGAACGCTCCTATAGTTCTCGAAATGGTAGTATTCCTACATATATGAGGCAGACGGAAGATGTGGCAGAAGTCCTCAATAGATGTGCTAG
TTCCAATTGGTCAGAAAGGAAAGAAGGCCTCCTAGGTCTGCAGAACTTATTAAAAAATCAGAGAACACTAAGTCGAGTTGAACTGAAAAG
ATTATGTGAAATTTTCACAAGAATGTTTGCTGACCCTCATGGCAAGGTATTCAGCATGTTTTTGGAGACTCTAGTGGATTTCATACAAGT
CCACAAAGATGATCTTCAAGATTGGTTGTTTGTACTGCTGACACAACTACTAAAAAAAATGGGTGCTGATTTGCTTGGATCTGTTCAGGC
AAAAGTTCAGAAAGCCCTTGATGTTACAAGAGAGTCTTTTCCAAATGATCTTCAGTTCAATATTCTAATGAGATTTACAGTTGATCAGAC
CCAGACACCAAGCTTAAAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAATTC
CAGTGAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGTGCT
GATTTCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCTTCT
TCATAATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAACTG
GTCCAGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTCTGA
AGATATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAAAAG
GGATTCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAGTCA
AACAGCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTATTC
AGATAGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCTAGA
TCATTCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACTTAT
GAAACTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAAAGA
GCCTACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGACTGT
CATGAAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAATTAG
TCCAGAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAAAGT
GATAGAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAGCAG
TGTTCGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGGCAG
TAAAATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAGTTA
GTGAAGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATCCTT
TGGAACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCATGTA
ACTTTTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCATTT
CACATGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCTTAA
AGCTTTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCGTAT
CATGTCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGATAC
ATGTCATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTGTAA
AACTGATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAATCA
TCTGCCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGATGC
TTTTTTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTTGAC
CGTCTTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCTTTT
ACCATGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTCTCT
ACCTCTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTTTAG
CAAATTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATTAGA
TAATTTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAGCTA
TTAGGGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGACAA
GAGTACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTACCT
GTAACAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTACAT
AACATTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACGGTC
TTGTATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATATAGC
TACATACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTTGGA
TATGTTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAGTAG
AGTGACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAACTA
CATAATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTCAGT
TGATAAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTCAGC
TACTTAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCATTTA

>90460_90460_5_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000359013_CLASP2_chr3_33686395_ENST00000399362_length(amino acids)=1765AA_BP=490
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQK
SCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT
SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE
LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE
YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM
APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGG
ASKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSA
KDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEF
LDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSS
SSQESLNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDKL
DGTASEDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSRE
ASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKK
PARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCEI
FTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTPS
LKVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHL
RNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSKK
DDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDL
VAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKTL
EAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRKA

--------------------------------------------------------------
>90460_90460_6_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000359013_CLASP2_chr3_33686395_ENST00000468888_length(transcript)=7970nt_BP=1754nt
ACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGGCCGCCGGGG
GCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGCCGGCCCGGC
GCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCTATGACGAGC
AGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACC
GCACGTTCAGAAGTCGGATGTGGAAATGGAGGCCCAGAAAGATGAAATCATCTGCCCCAGCTGTAATAGGACTGCCCATCCACTGAGACA
TATTAATAACGACATGATAGTCACTGACAACAACGGTGCAGTCAAGTTTCCACAACTGTGTAAATTTTGTGATGTGAGATTTTCCACCTG
TGACAACCAGAAATCCTGCATGAGCAACTGCAGCATCACCTCCATCTGTGAGAAGCCACAGGAAGTCTGTGTGGCTGTATGGAGAAAGAA
TGACGAGAACATAACACTAGAGACAGTTTGCCATGACCCCAAGCTCCCCTACCATGACTTTATTCTGGAAGATGCTGCTTCTCCAAAGTG
CATTATGAAGGAAAAAAAAAAGCCTGGTGAGACTTTCTTCATGTGTTCCTGTAGCTCTGATGAGTGCAATGACAACATCATCTTCTCAGA
AGAATATAACACCAGCAATCCTGACTTGTTGCTAGTCATATTTCAAGTGACAGGCATCAGCCTCCTGCCACCACTGGGAGTTGCCATATC
TGTCATCATCATCTTCTACTGCTACCGCGTTAACCGGCAGCAGAAGCTGAGTTCAACCTGGGAAACCGGCAAGACGCGGAAGCTCATGGA
GTTCAGCGAGCACTGTGCCATCATCCTGGAAGATGACCGCTCTGACATCAGCTCCACGTGTGCCAACAACATCAACCACAACACAGAGCT
GCTGCCCATTGAGCTGGACACCCTGGTGGGGAAAGGTCGCTTTGCTGAGGTCTATAAGGCCAAGCTGAAGCAGAACACTTCAGAGCAGTT
TGAGACAGTGGCAGTCAAGATCTTTCCCTATGAGGAGTATGCCTCTTGGAAGACAGAGAAGGACATCTTCTCAGACATCAATCTGAAGCA
TGAGAACATACTCCAGTTCCTGACGGCTGAGGAGCGGAAGACGGAGTTGGGGAAACAATACTGGCTGATCACCGCCTTCCACGCCAAGGG
CAACCTACAGGAGTACCTGACGCGGCATGTCATCAGCTGGGAGGACCTGCGCAAGCTGGGCAGCTCCCTCGCCCGGGGGATTGCTCACCT
CCACAGTGATCACACTCCATGTGGGAGGCCCAAGATGCCCATCGTGCACAGGGACCTCAAGAGCTCCAATATCCTCGTGAAGAACGACCT
AACCTGCTGCCTGTGTGACTTTGGGCTTTCCCTGCGTCTGGACCCTACTCTGTCTGTGGATGACCTGGCTAACAGTGGGCAGGTGGGAAC
TGCAAGATACATGGCTCCAGAAGTCCTAGAATCCAGGATGAATTTGGAGAATGTTGAGTCCTTCAAGCAGACCGATGTCTACTCCATGGC
TCTGGTGCTCTGGGAAATGACATCTCGCTGTAATGCAGTGGGAGATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATC
ATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCC
TAAGGTTGGAGCAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTAT
TCAGATTTATTCTAGTCGAGAACTCGAAGAAACATTAAATAAAATCAGGGAAATTTTGTCAGATGATAAACATGACTGGGATCAGCGTGC
CAATGCACTGAAGAAAATTCGATCACTGCTTGTTGCTGGAGCTGCACAGTATGATTGCTTTTTTCAACATTTACGATTGTTGGATGGAGC
ACTTAAACTTTCAGCTAAGGATCTTAGATCCCAGGTGGTTAGAGAAGCTTGTATTACTGTAGCCCACCTTTCAACAGTTTTGGGAAACAA
GTTTGATCATGGCGCTGAAGCCATTGTACCTACACTTTTTAATCTCGTCCCCAATAGTGCAAAAGTCATGGCAACTTCTGGATGTGCAGC
AATCAGATTTATCATTCGGCATACTCATGTACCCAGACTTATACCTTTAATAACAAGCAATTGCACATCAAAATCAGTTCCCGTGAGGAG
ACGTTCATTTGAATTTTTAGATTTATTGTTGCAAGAGTGGCAGACTCATTCATTGGAAAGACATGCAGCCGTCTTGGTTGAAACTATTAA
AAAGGGAATTCATGATGCTGACGCTGAGGCCAGAGTGGAGGCAAGAAAGACATACATGGGTCTTAGAAACCACTTTCCTGGTGAAGCTGA
AACATTATATAATTCCCTTGAGCCATCTTATCAGAAGAGTCTTCAAACTTACTTAAAGAGTTCTGGCAGTGTAGCATCTCTTCCACAATC
AGACAGGTCCTCATCCAGCTCACAGGAAAGTCTCAATCGCCCTTTTTCTTCCAAATGGTCTACAGCAAATCCATCAACTGTGGCTGGAAG
AGTATCAGCAGGCAGCAGCAAAGCCAGTTCCCTTCCAGGAAGCCTGCAGCGTTCACGAAGTGACATTGATGTGAATGCTGCTGCAGGTGC
CAAGGCACATCATGCTGCTGGACAGTCTGTGCGAAGCGGGCGCTTAGGTGCAGGTGCCCTGAATGCAGGTTCCTATGCGTCACTAGAGGA
TACTTCTGACAAGCTGGATGGAACAGCATCTGAAGATGGCCGGGTGAGAGCAAAACTTTCAGCACCACTTGCTGGCATGGGAAATGCCAA
GGCAGATTCTAGAGGAAGAAGTCGAACAAAAATGGTGTCTCAATCACAGCCTGGTAGCCGGTCTGGGTCTCCAGGAAGAGTTCTGACCAC
AACAGCCCTGTCCACTGTGAGCTCTGGTGTTCAAAGAGTCCTGGTCAATTCAGCCTCAGCACAAAAAAGAAGCAAGATACCACGGAGCCA
GGGCTGTAGCAGAGAGGCTAGTCCATCTAGGCTTTCAGTGGCCCGAAGCAGTCGTATTCCTCGACCAAGTGTGAGTCAAGGATGCAGCCG
GGAAGCTAGTCGGGAGAGCAGCAGAGACACAAGTCCTGTTCGCTCTTTTCAGCCCCTCGGTCCAGGTTATGGGATCAGCCAATCAAGTCG
ACTGTCGTCTTCTGTTAGTGCCATGCGAGTCCTGAACACAGGTTCTGATGTGGAGGAGGCGGTGGCAGATGCCTTGCTCTTAGGAGACAT
ACGGACTAAGAAAAAACCAGCTCGAAGAAGATATGAATCATATGGAATGCATTCAGATGATGACGCCAACAGCGATGCATCTAGTGCTTG
TTCAGAACGCTCCTATAGTTCTCGAAATGGTAGTATTCCTACATATATGAGGCAGACGGAAGATGTGGCAGAAGTCCTCAATAGATGTGC
TAGTTCCAATTGGTCAGAAAGGAAAGAAGGCCTCCTAGGTCTGCAGAACTTATTAAAAAATCAGAGAACACTAAGTCGAGTTGAACTGAA
AAGATTATGTGAAATTTTCACAAGAATGTTTGCTGACCCTCATGGCAAGGTATTCAGCATGTTTTTGGAGACTCTAGTGGATTTCATACA
AGTCCACAAAGATGATCTTCAAGATTGGTTGTTTGTACTGCTGACACAACTACTAAAAAAAATGGGTGCTGATTTGCTTGGATCTGTTCA
GGCAAAAGTTCAGAAAGCCCTTGATGTTACAAGAGAGTCTTTTCCAAATGATCTTCAGTTCAATATTCTAATGAGATTTACAGTTGATCA
GACCCAGACACCAAGCTTAAAGGTGAAGGTTGCTATCCTTAAATACATAGAAACTCTGGCCAAACAGATGGATCCAGGAGATTTTATAAA
TTCCAGTGAAACTCGCCTAGCAGTGTCTCGGGTCATCACTTGGACAACAGAACCCAAAAGTTCTGATGTTCGGAAGGCAGCACAGTCAGT
GCTGATTTCATTATTTGAACTCAATACCCCAGAGTTTACAATGTTATTAGGAGCTTTACCAAAAACTTTTCAGGATGGTGCTACCAAGCT
TCTTCATAATCACCTTCGAAACACTGGCAATGGAACCCAGAGTTCCATGGGGAGTCCTTTGACAAGACCAACACCACGATCACCAGCTAA
CTGGTCCAGTCCTCTTACTTCTCCTACCAATACATCACAGAATACTTTATCTCCAAGTGCATTTGATTATGACACAGAAAATATGAACTC
TGAAGATATTTATAGCTCTCTTAGAGGTGTCACTGAAGCAATCCAGAATTTCAGCTTCCGTAGCCAAGAAGATATGAATGAGCCATTGAA
AAGGGATTCTAAAAAAGATGATGGCGATTCAATGTGTGGTGGTCCTGGGATGTCTGACCCAAGAGCAGGAGGTGATGCTACTGACTCAAG
TCAAACAGCTCTTGATAATAAAGCTTCATTGCTCCATTCAATGCCTACTCACTCCTCTCCACGCTCTCGAGACTATAATCCATATAACTA
TTCAGATAGCATCAGTCCCTTCAACAAGTCTGCCCTCAAGGAAGCCATGTTTGATGATGATGCTGACCAGTTTCCTGACGATCTTTCCCT
AGATCATTCTGACCTAGTTGCAGAGTTGTTGAAGGAGCTGTCTAACCATAATGAGCGTGTAGAAGAAAGAAAAATTGCCCTCTATGAACT
TATGAAACTGACACAGGAAGAATCTTTTAGTGTTTGGGATGAACACTTCAAAACAATATTGCTTTTATTGCTTGAAACGCTTGGAGATAA
AGAGCCTACAATCAGGGCTTTGGCATTAAAGGTTTTAAGAGAAATCCTAAGGCATCAACCAGCAAGATTTAAAAACTATGCAGAATTGAC
TGTCATGAAAACATTGGAAGCACATAAAGATCCTCATAAGGAGGTGGTGAGATCTGCTGAGGAAGCGGCATCAGTGTTGGCCACTTCAAT
TAGTCCAGAGCAGTGCATCAAAGTGCTTTGTCCTATCATTCAAACTGCAGACTACCCAATTAATCTGGCTGCAATCAAAATGCAAACAAA
AGTGATAGAGAGAGTGTCCAAGGAAACCCTAAACCTGCTTTTGCCAGAGATTATGCCAGGTCTAATACAGGGTTATGATAATTCAGAGAG
CAGTGTTCGGAAAGCTTGTGTCTTCTGCCTGGTGGCTGTTCATGCGGTAATTGGTGATGAACTAAAACCACATCTCAGTCAACTTACTGG
CAGTAAAATGAAGCTACTGAATCTTTACATCAAACGTGCACAAACAGGTTCTGGAGGAGCTGATCCCACTACTGATGTTTCTGGACAAAG
TTAGTGAAGCTCATCACAGCGAACCAGGTCTCTCAAAAGAAAGGACAGATAGACCACCCTCATCAATGAAAGGAAGTTCTCAAACACATC
CTTTGGAACTTACTATTGTTTCCCAGTTTTAGTTTTTTGTTTCGTTTCGTTTTGTATTTTCTGTAACAGAGGACTATCCTCAGTCTGCAT
GTAACTTTTATGATAGTTATTCCAAATTCAAGAAGAAGCAGTATTAACATCAATTGATCGACACAAAGTAATTTTTAATTTAATTCATCA
TTTCACATGTTTGTACTTTGTCTTCCCATTAACCTTTGCCAGTGTTATGATTGTATAAATTTTTTTAAATGCTGGTTAAACAGGAATGCT
TAAAGCTTTAAAAGTTTAACAGTCTAAAACATTTTTGCTTTTATTCAACTGCAGAATAATATTTTTATTGCTACTTTGAGTTTTGTTTCG
TATCATGTCCTATGCTAGAAATATTTAAATGATGTGAAACAAAGCAGGACTAATTTGAACTACAGCTGGACTCCGTTTGTGTGATGGTGA
TACATGTCATTAGTTGCAACTTCTTTGGGGTGATCTATAGTTTGAAAACTAAAACCTCAAAGACAGATGTTACAGAATCAGCCAGTTCTG
TAAAACTGATATTGTCTATTGGTTATTGATCTTGCCATCTTTATTTAAAACCATGTCCCTTCTATGATCCCTTAAGAAAGCTGCACCAAA
TCATCTGCCTGTTTTTTCTTGATACTTACTGAAATAGAAGGTTTTATTGCAGGGTTTATTTTGGTTTGTTTATATCTTTGTTGTGAATGA
TGCTTTTTTGTATTTATTAATATCAAATTCACTTATGAATAAACTTGATAATGGAAACGGACAAAAAAAATCAAGTGCGTGTGTGTCCTT
GACCGTCTTCTGTTTCTCACGTAATAAACAAATTATCGAGACATGGGAGTGACCAGCACCTTTTCTTTAAATGGTGGAACCTGGTTTCCT
TTTACCATGAAATTGTCTTACTTGAAAATATTGATCCTGATGAGAGAGAAGATGGTGCCAAGGCTGTCTTTGTATAATGGGCTCAAATTC
TCTACCTCTTCAGGGCTAATACTTTTAACTGAGCTGCTGCCTATAGTGTCTTTTGGAAAACTACTTAAAGGGTGATTTTCTGTTACTTTT
TAGCAAATTTTTTTAATCACCTCTTGCTACACCCATTCTTTTCATGTGCAGCCGACTCAAAAATTACCAGTTTTGGTGAAAGGCTAAATT
AGATAATTTGGAACCAGGATACTAATGATTTCTCATCTTTACTTTTTTTTAATCCTAATATAAAGTGAATTTGATTGAAAAGGCAAATAG
CTATTAGGGAAGCAGTTTGCCATTGTTGCAGAGTTATCTGTACTTTGTTTAACTGAAAAAAATGTAGAAATATATGTAAAGAATTTAAGA
CAAGAGTACTGAATGGATGATTTGTCATAGGCTTTCCCCTTTCTTTCTGTTCTAGCAGCAGGAAAAGTTTCTCTATATCCTCTCCCTCTA
CCTGTAACAATTTTGTTTTCTACTGTTAATTACATTGTGTATTTATAGTTCTATGCTTACTGTTGTGCATATACTGGCAATAAAACTGTA
CATAACATTACTTGAAAAAGTTAATAATGTATATCAGTTTTTCTGTCTCACTGTGTAACAAGTCACTCAGTTTTATTTTAACTTTAGACG
GTCTTGTATCAGTGGTGGTCTCTTGAATTTTGTAAGTTCATCTGAGGAGAAAAGATTTTTCAGGTGTAGCTACCACAATCAAAGGTATAT
AGCTACATACGCATGTATATATTACAGCTTATCTGTAAGAAGAAAATGCATTTTAAACACAACTCTTCTCAGTAGCATTTTATGACCTTT
GGATATGTTTGTAATCATTTCGAATCAAAATATTGATTTAATTTTGACCTCTGGTTTAAGATACTGCTTTAACTACTGTTGACAACCAAG
TAGAGTGACTTAAGCTGAACAGTAACTAACTGGAAAATTAGATAAGCACCTGGCATCTAATGGCAGGCAGGCACTCAAGAAATGAATTAA
CTACATAATGGAAAAGTATGGTTTAATGTGTCCAAATGAAAGCTAGTAGATGTAAACATGGAAAAATTGTGTTTACAATTTTATAATCTC
AGTTGATAAGACTATAAGAAAGCTGATTATTTAAATCACTATATACAATACACCCTTAATTTGTTCATTCCAGAAACATACTGAGATGTC
AGCTACTTAAAAATGGTCACAAAAAGCTACTGTTTATATTTTTCCTCCTGCTATTCTCTCCCAAATTAATTATTAATAAGTGTTGTTCAT

>90460_90460_6_TGFBR2-CLASP2_TGFBR2_chr3_30715738_ENST00000359013_CLASP2_chr3_33686395_ENST00000468888_length(amino acids)=1766AA_BP=490
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRTAHPLRHINNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQK
SCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNT
SNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE
LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE
YLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM
APEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGA
GASKEGGAGAVDEDDFIKAFTDVPSIQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLS
AKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFE
FLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSS
SSSQESLNRPFSSKWSTANPSTVAGRVSAGSSKASSLPGSLQRSRSDIDVNAAAGAKAHHAAGQSVRSGRLGAGALNAGSYASLEDTSDK
LDGTASEDGRVRAKLSAPLAGMGNAKADSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGVQRVLVNSASAQKRSKIPRSQGCSR
EASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKK
KPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRVELKRLCE
IFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDVTRESFPNDLQFNILMRFTVDQTQTP
SLKVKVAILKYIETLAKQMDPGDFINSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNH
LRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMNEPLKRDSK
KDDGDSMCGGPGMSDPRAGGDATDSSQTALDNKASLLHSMPTHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSD
LVAELLKELSNHNERVEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLREILRHQPARFKNYAELTVMKT
LEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNLLLPEIMPGLIQGYDNSESSVRK

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Fusion Gene PPI Analysis for TGFBR2-CLASP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCLASP2chr3:30715738chr3:33686395ENST00000313350013444_58011.333333333333334432.0microtubules%2C MAPRE1 and MAPRE3
TgeneCLASP2chr3:30715738chr3:33686395ENST00000313350013872_129411.333333333333334432.0RSN and localization to the Golgi and kinetochores


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TGFBR2-CLASP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TGFBR2-CLASP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource