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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TGFBR2-XPC (FusionGDB2 ID:90466)

Fusion Gene Summary for TGFBR2-XPC

check button Fusion gene summary
Fusion gene informationFusion gene name: TGFBR2-XPC
Fusion gene ID: 90466
HgeneTgene
Gene symbol

TGFBR2

XPC

Gene ID

7048

7508

Gene nametransforming growth factor beta receptor 2XPC complex subunit, DNA damage recognition and repair factor
SynonymsAAT3|FAA3|LDS1B|LDS2|LDS2B|MFS2|RIIC|TAAD2|TBR-ii|TBRII|TGFR-2|TGFbeta-RIIRAD4|XP3|XPCC|p125
Cytomap

3p24.1

3p25.1

Type of geneprotein-codingprotein-coding
DescriptionTGF-beta receptor type-2TGF-beta receptor type IIBTGF-beta type II receptortbetaR-IItransforming growth factor beta receptor IItransforming growth factor beta receptor type IICtransforming growth factor, beta receptor II (70/80kDa)transforming growDNA repair protein complementing XP-C cellsmutant xeroderma pigmentosum group Cxeroderma pigmentosum, complementation group C
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000295754, ENST00000359013, 
ENST00000285021, ENST00000449060, 
Fusion gene scores* DoF score9 X 6 X 7=3785 X 4 X 4=80
# samples 95
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TGFBR2 [Title/Abstract] AND XPC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTGFBR2(30648469)-XPC(14214562), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTGFBR2

GO:0006468

protein phosphorylation

12015308

HgeneTGFBR2

GO:0006915

apoptotic process

17471240

HgeneTGFBR2

GO:0007179

transforming growth factor beta receptor signaling pathway

18453574

HgeneTGFBR2

GO:0010718

positive regulation of epithelial to mesenchymal transition

26459119

HgeneTGFBR2

GO:0018105

peptidyl-serine phosphorylation

12015308

HgeneTGFBR2

GO:0018107

peptidyl-threonine phosphorylation

12015308

HgeneTGFBR2

GO:0042493

response to drug

17878231

HgeneTGFBR2

GO:0060389

pathway-restricted SMAD protein phosphorylation

18453574

HgeneTGFBR2

GO:0070723

response to cholesterol

17878231

HgeneTGFBR2

GO:2000563

positive regulation of CD4-positive, alpha-beta T cell proliferation

17164348

TgeneXPC

GO:0000715

nucleotide-excision repair, DNA damage recognition

10873465|19941824

TgeneXPC

GO:0006289

nucleotide-excision repair

8168482|9734359|11259578

TgeneXPC

GO:0045893

positive regulation of transcription, DNA-templated

29973595|31527837

TgeneXPC

GO:0070914

UV-damage excision repair

8077226


check buttonFusion gene breakpoints across TGFBR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across XPC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1L2-01ATGFBR2chr3

30648469

-XPCchr3

14214562

-
ChimerDB4SARCTCGA-DX-A1L2-01ATGFBR2chr3

30648469

+XPCchr3

14214562

-
ChimerDB4SARCTCGA-DX-A1L2TGFBR2chr3

30648469

+XPCchr3

14214562

-
ChimerDB4SARCTCGA-DX-A8BJ-01ATGFBR2chr3

30648469

+XPCchr3

14214562

-


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Fusion Gene ORF analysis for TGFBR2-XPC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000295754ENST00000285021TGFBR2chr3

30648469

+XPCchr3

14214562

-
In-frameENST00000295754ENST00000449060TGFBR2chr3

30648469

+XPCchr3

14214562

-
In-frameENST00000359013ENST00000285021TGFBR2chr3

30648469

+XPCchr3

14214562

-
In-frameENST00000359013ENST00000449060TGFBR2chr3

30648469

+XPCchr3

14214562

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295754TGFBR2chr330648469+ENST00000285021XPCchr314214562-39904763823195937
ENST00000295754TGFBR2chr330648469+ENST00000449060XPCchr314214562-30854763823084901
ENST00000359013TGFBR2chr330648469+ENST00000285021XPCchr314214562-38913772833096937
ENST00000359013TGFBR2chr330648469+ENST00000449060XPCchr314214562-29863772832985901

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295754ENST00000285021TGFBR2chr330648469+XPCchr314214562-0.0010817850.9989183
ENST00000295754ENST00000449060TGFBR2chr330648469+XPCchr314214562-0.0027356190.9972644
ENST00000359013ENST00000285021TGFBR2chr330648469+XPCchr314214562-0.0011205910.9988794
ENST00000359013ENST00000449060TGFBR2chr330648469+XPCchr314214562-0.002865060.9971349

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Fusion Genomic Features for TGFBR2-XPC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TGFBR2-XPC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:30648469/chr3:14214562)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016124_13034941.0Compositional biasNote=Poly-Glu
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016359_39534941.0Compositional biasNote=Lys-rich (basic)
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016408_43134941.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016432_46134941.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016466_49334941.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016501_50734941.0Compositional biasNote=Poly-Ser
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016124_13034904.0Compositional biasNote=Poly-Glu
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016359_39534904.0Compositional biasNote=Lys-rich (basic)
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016408_43134904.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016432_46134904.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016466_49334904.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016501_50734904.0Compositional biasNote=Poly-Ser
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016390_39534941.0MotifNuclear localization signal
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016390_39534904.0MotifNuclear localization signal
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016607_74134941.0RegionNote=DNA-binding%3B preference for heteroduplex DNA
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016607_76634941.0RegionNote=Minimal sensor domain involved in damage recognition
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016767_83134941.0RegionNote=DNA-binding%3B preference for single stranded DNA%3B required for formation of stable nucleoprotein complex
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016607_74134904.0RegionNote=DNA-binding%3B preference for heteroduplex DNA
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016607_76634904.0RegionNote=Minimal sensor domain involved in damage recognition
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016767_83134904.0RegionNote=DNA-binding%3B preference for single stranded DNA%3B required for formation of stable nucleoprotein complex

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000295754+17244_54431568.0DomainProtein kinase
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000359013+18244_54431593.0DomainProtein kinase
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000295754+17250_25831568.0Nucleotide bindingATP
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000359013+18250_25831593.0Nucleotide bindingATP
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000295754+17188_56731568.0Topological domainCytoplasmic
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000295754+1723_16631568.0Topological domainExtracellular
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000359013+18188_56731593.0Topological domainCytoplasmic
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000359013+1823_16631593.0Topological domainExtracellular
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000295754+17167_18731568.0TransmembraneHelical
HgeneTGFBR2chr3:30648469chr3:14214562ENST00000359013+18167_18731593.0TransmembraneHelical
TgeneXPCchr3:30648469chr3:14214562ENST0000028502101630_17734941.0Compositional biasNote=Glu-rich (acidic)
TgeneXPCchr3:30648469chr3:14214562ENST0000028502101630_3434941.0Compositional biasNote=Poly-Glu
TgeneXPCchr3:30648469chr3:14214562ENST0000044906001630_17734904.0Compositional biasNote=Glu-rich (acidic)
TgeneXPCchr3:30648469chr3:14214562ENST0000044906001630_3434904.0Compositional biasNote=Poly-Glu


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Fusion Gene Sequence for TGFBR2-XPC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90466_90466_1_TGFBR2-XPC_TGFBR2_chr3_30648469_ENST00000295754_XPC_chr3_14214562_ENST00000285021_length(transcript)=3990nt_BP=476nt
GGAGAGGGAGAAGGCTCTCGGGCGGAGAGAGGTCCTGCCCAGCTGTTGGCGAGGAGTTTCCTGTTTCCCCCGCAGCGCTGAGTTGAAGTT
GAGTGAGTCACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGG
CCGCCGGGGGCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGC
CGGCCCGGCGCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCT
ATGACGAGCAGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCAC
GATCCCACCGCACGTTCAGAAGTCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAG
GAAAAGAGGCTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAA
GGTTATAAAGGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGC
TACCATGAATGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAACTTAGTGAGCCTGTGCTGGGTGA
CGTGAGAGAAAGTACAGCCTTCTCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAACGCCAGAGCAGGCGAAGACAAG
AGAAAGAAGTGAAAAGATAAAACTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACA
CAAGGTTCACCTTCTCTGCCTGCTAGCAAATGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCAT
CATCCCAGCCCGCTTTACCAGAGTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTAC
AGTTAATGCAGAACTTTCAGCCAGTGAACAAGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGA
GGAATTGGTCCATATATTCTTACTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTC
AGCAACAGCAAAGGGAAAGAAACCTTCCAAGGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAA
CCACACCAAACCAAAGACCAGCAAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAA
CAAGGGAGGCAGAAAGAAACGGAGCAAGCCCTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACG
TCCGCATGGCCGGGAGCGGCGGGTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGA
GCTCTCCAGTGGAGAAGCCTCTGATCCCTCTGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGAC
AAAGGCTGGGTCCAAGAGTGCCTCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAG
CAGTAAAAGAGGCAAGAAAATGTGCAGCGATGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTG
TGAGCAGGAGGAAAAGTGGGTATGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCAT
GACCTATGTGGTGGGCATTGACAGTGACGGCTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTG
CCGGGTTGATGCTGAGTGGTGGGCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCA
GGCTAAACACATGGACCAGCCTTTGCCCACTGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATA
TGAGGCCATCTATCCCGAGACAGCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTC
CAGGGACACGTGGCTGAAGAAAGCAAGAGTGGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAA
AGCCCGACTTGCTGAGCCCCAGCTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGC
CGTGGACGGGAAGGTGCCCCGGAACGAGTTTGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCT
GCCCAATCTACACCGCGTGGCCCGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCC
CGTGACTGATGGATACATCGTCTGCGAGGAATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGA
GAAGGAGAAAAAGGAGAAGCGGGCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGG
GCCCAAGAGTGAGGCAGCAGCTCCCCACACAGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGC
GGCCAGGATACTGGCTGCCTCCTGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGA
AAAGAAAGCAGCAGCTTCCCACCTGTTCCCATTTGAGCAGCTGTGAGCTGAGCGCCCACTAGAGGGGCACCCACCAGTTGCTGCTGCCCC
ACTACAGGCCCCACACCTGCCCTGGGCATGCCCAGCCCCTGGTGGTGGGGGCTTCTCTGCTGAGAAGGCAAACTGAGGCAGCATGCACGG
AGGCGGGGTCAGGGGAGACGAGGCCAAGCTGAGGAGGTGCTGCAGGTCCCGTCTGGCTCCAGCCCTTGTCAGATTCACCCAGGGTGAAGC
CTTCAAAGCTTTTTGCTACCAAAGCCCACTCACCCTTTGAGCTACAGAACACTTTGCTAGGAGATACTCTTCTGCCTCCTAGACCTGTTC
TTTCCATCTTTAGAAACATCAGTTTTTGTATGGAAGCCACCGGGAGATTTCTGGATGGTGGTGCATCCGTGAATGCGCTGATCGTTTCTT
CCAGTTAGAGTCTTCATCTGTCCGACAAGTTCACTCGCCTCGGTTGCGGACCTAGGACCATTTCTCTGCAGGCCACTTACCTTCCCCTGA
GTCAGGCTTACTAATGCTGCCCTCACTGCCTCTTTGCAGTAGGGGAGAGAGCAGAGAAGTACAGGTCATCTGCTGGGATCTAGTTTTCCA
AGTAACATTTTGTGGTGACAGAAGCCTAAAAAAAGCTAAAATCAGGAAAGAAAAGGAAAAATACGAATTGAAAATTAAGGAAATGTTAGT
AAAATAGATGAGTGTTAAACTAGATTGTATTCATTACTAGATAAAATGTATAAAGCTCTCTGTACTAAGGAGAAATGACTTTTATAACAT

>90466_90466_1_TGFBR2-XPC_TGFBR2_chr3_30648469_ENST00000295754_XPC_chr3_14214562_ENST00000285021_length(amino acids)=937AA_BP=31
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEAL
SDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSEKIK
LEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSA
SEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTS
KGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEAS
DPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWV
CVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQP
LPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQ
LREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIV
CEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAAS

--------------------------------------------------------------
>90466_90466_2_TGFBR2-XPC_TGFBR2_chr3_30648469_ENST00000295754_XPC_chr3_14214562_ENST00000449060_length(transcript)=3085nt_BP=476nt
GGAGAGGGAGAAGGCTCTCGGGCGGAGAGAGGTCCTGCCCAGCTGTTGGCGAGGAGTTTCCTGTTTCCCCCGCAGCGCTGAGTTGAAGTT
GAGTGAGTCACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGG
CCGCCGGGGGCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGC
CGGCCCGGCGCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCT
ATGACGAGCAGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCAC
GATCCCACCGCACGTTCAGAAGTCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAG
GAAAAGAGGCTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAA
GGTTATAAAGGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGC
TACCATGAATGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGCGAAGACAAGAGAAAGAAGTGAAAAGATAAA
ACTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCT
GCTAGCAAATGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGCTTTACCAG
AGTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGC
CAGTGAACAAGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCATATATTCTT
ACTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAA
ACCTTCCAAGGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCAAAGACCAG
CAAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACG
GAGCAAGCCCTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGGGAGCGGCG
GGTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTC
TGATCCCTCTGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCCAAGAGTGC
CTCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAAT
GTGCAGCGATGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAAAAGTGGGT
ATGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGA
CAGTGACGGCTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCTGAGTGGTG
GGCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACACATGGACCAGCC
TTTGCCCACTGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTATCCCGAGAC
AGCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACACGTGGCTGAAGAA
AGCAAGAGTGGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCTGAGCCCCA
GCTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCG
GAACGAGTTTGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACACCGCGTGGC
CCGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGATGGATACATCGT
CTGCGAGGAATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAGGAGAAGCG
GGCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGC
TCCCCACACAGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTGGCTGCCTC
CTGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCA

>90466_90466_2_TGFBR2-XPC_TGFBR2_chr3_30648469_ENST00000295754_XPC_chr3_14214562_ENST00000449060_length(amino acids)=901AA_BP=31
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEAL
SDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEAKTRERSEKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYR
NNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQ
LLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSE
EDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGS
HRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRD
VTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYC
RGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVY
LFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKL
LAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEQL

--------------------------------------------------------------
>90466_90466_3_TGFBR2-XPC_TGFBR2_chr3_30648469_ENST00000359013_XPC_chr3_14214562_ENST00000285021_length(transcript)=3891nt_BP=377nt
ACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGGCCGCCGGGG
GCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGCCGGCCCGGC
GCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCTATGACGAGC
AGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACC
GCACGTTCAGAAGTCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGG
CTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAA
GGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAA
TGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGTTGAAGAACTTAGTGAGCCTGTGCTGGGTGACGTGAGAGA
AAGTACAGCCTTCTCTCGATCTCTTCTGCCTGTGAAGCCAGTGGAGATAGAGATTGAAACGCCAGAGCAGGCGAAGACAAGAGAAAGAAG
TGAAAAGATAAAACTGGAGTTTGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCA
CCTTCTCTGCCTGCTAGCAAATGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGC
CCGCTTTACCAGAGTGCTGCCTCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGC
AGAACTTTCAGCCAGTGAACAAGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGT
CCATATATTCTTACTGATTCTCCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGC
AAAGGGAAAGAAACCTTCCAAGGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAA
ACCAAAGACCAGCAAAGGAACCAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGG
CAGAAAGAAACGGAGCAAGCCCTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGG
CCGGGAGCGGCGGGTGGCCTCCAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAG
TGGAGAAGCCTCTGATCCCTCTGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGG
GTCCAAGAGTGCCTCCAGGACCCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAG
AGGCAAGAAAATGTGCAGCGATGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGA
GGAAAAGTGGGTATGTGTAGACTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGT
GGTGGGCATTGACAGTGACGGCTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGA
TGCTGAGTGGTGGGCCGAGACCTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACA
CATGGACCAGCCTTTGCCCACTGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCAT
CTATCCCGAGACAGCTGCCATCCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACAC
GTGGCTGAAGAAAGCAAGAGTGGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACT
TGCTGAGCCCCAGCTGCGGGAAGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGG
GAAGGTGCCCCGGAACGAGTTTGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCT
ACACCGCGTGGCCCGCAAGCTGGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGA
TGGATACATCGTCTGCGAGGAATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAA
AAAGGAGAAGCGGGCTCTAGGGAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAG
TGAGGCAGCAGCTCCCCACACAGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGAT
ACTGGCTGCCTCCTGGCCTCAAAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGC
AGCAGCTTCCCACCTGTTCCCATTTGAGCAGCTGTGAGCTGAGCGCCCACTAGAGGGGCACCCACCAGTTGCTGCTGCCCCACTACAGGC
CCCACACCTGCCCTGGGCATGCCCAGCCCCTGGTGGTGGGGGCTTCTCTGCTGAGAAGGCAAACTGAGGCAGCATGCACGGAGGCGGGGT
CAGGGGAGACGAGGCCAAGCTGAGGAGGTGCTGCAGGTCCCGTCTGGCTCCAGCCCTTGTCAGATTCACCCAGGGTGAAGCCTTCAAAGC
TTTTTGCTACCAAAGCCCACTCACCCTTTGAGCTACAGAACACTTTGCTAGGAGATACTCTTCTGCCTCCTAGACCTGTTCTTTCCATCT
TTAGAAACATCAGTTTTTGTATGGAAGCCACCGGGAGATTTCTGGATGGTGGTGCATCCGTGAATGCGCTGATCGTTTCTTCCAGTTAGA
GTCTTCATCTGTCCGACAAGTTCACTCGCCTCGGTTGCGGACCTAGGACCATTTCTCTGCAGGCCACTTACCTTCCCCTGAGTCAGGCTT
ACTAATGCTGCCCTCACTGCCTCTTTGCAGTAGGGGAGAGAGCAGAGAAGTACAGGTCATCTGCTGGGATCTAGTTTTCCAAGTAACATT
TTGTGGTGACAGAAGCCTAAAAAAAGCTAAAATCAGGAAAGAAAAGGAAAAATACGAATTGAAAATTAAGGAAATGTTAGTAAAATAGAT
GAGTGTTAAACTAGATTGTATTCATTACTAGATAAAATGTATAAAGCTCTCTGTACTAAGGAGAAATGACTTTTATAACATTTTGAGAAA

>90466_90466_3_TGFBR2-XPC_TGFBR2_chr3_30648469_ENST00000359013_XPC_chr3_14214562_ENST00000285021_length(amino acids)=937AA_BP=31
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEAL
SDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEVEELSEPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSEKIK
LEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSA
SEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTS
KGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSEEDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEAS
DPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWV
CVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQP
LPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQ
LREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIV
CEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAAS

--------------------------------------------------------------
>90466_90466_4_TGFBR2-XPC_TGFBR2_chr3_30648469_ENST00000359013_XPC_chr3_14214562_ENST00000449060_length(transcript)=2986nt_BP=377nt
ACTCGCGCGCACGGAGCGACGACACCCCCGCGCGTGCACCCGCTCGGGACAGGAGCCGGACTCCTGTGCAGCTTCCCTCGGCCGCCGGGG
GCCTCCCCGCGCCTCGCCGGCCTCCAGGCCCCCTCCTGGCTGGCGAGCGGGCGCCACATCTGGCCCGCACATCTGCGCTGCCGGCCCGGC
GCGGGGTCCGGAGAGGGCGCGGCGCGGAGGCGCAGCCAGGGGTCCGGGAAGGCGCCGTCCGCTGCGCTGGGGGCTCGGTCTATGACGAGC
AGCGGGGTCTGCCATGGGTCGGGGGCTGCTCAGGGGCCTGTGGCCGCTGCACATCGTCCTGTGGACGCGTATCGCCAGCACGATCCCACC
GCACGTTCAGAAGTCGGATGCCTTTGAAGATGAGAAACCCCCAAAGAAGAGCCTTCTCTCCAAAGTTTCACAAGGAAAGAGGAAAAGAGG
CTGCAGTCATCCTGGGGGTTCAGCAGATGGTCCAGCAAAAAAGAAAGTGGCCAAGGTGACTGTTAAATCTGAAAACCTCAAGGTTATAAA
GGATGAAGCCCTCAGCGATGGGGATGACCTCAGGGACTTTCCAAGTGACCTCAAGAAGGCACACCATCTGAAGAGAGGGGCTACCATGAA
TGAAGACAGCAATGAAGAAGAGGAAGAAAGTGAAAATGATTGGGAAGAGGCGAAGACAAGAGAAAGAAGTGAAAAGATAAAACTGGAGTT
TGAGACATATCTTCGGAGGGCGATGAAACGTTTCAATAAAGGGGTCCATGAGGACACACACAAGGTTCACCTTCTCTGCCTGCTAGCAAA
TGGCTTCTATCGAAATAACATCTGCAGCCAGCCAGATCTGCATGCTATTGGCCTGTCCATCATCCCAGCCCGCTTTACCAGAGTGCTGCC
TCGAGATGTGGACACCTACTACCTCTCAAACCTGGTGAAGTGGTTCATTGGAACATTTACAGTTAATGCAGAACTTTCAGCCAGTGAACA
AGATAACCTGCAGACTACATTGGAAAGGAGATTTGCTATTTACTCTGCTCGAGATGATGAGGAATTGGTCCATATATTCTTACTGATTCT
CCGGGCTCTGCAGCTCTTGACCCGGCTGGTATTGTCTCTACAGCCAATTCCTCTGAAGTCAGCAACAGCAAAGGGAAAGAAACCTTCCAA
GGAAAGATTGACTGCGGATCCAGGAGGCTCCTCAGAAACTTCCAGCCAAGTTCTAGAAAACCACACCAAACCAAAGACCAGCAAAGGAAC
CAAACAAGAGGAAACCTTTGCTAAGGGCACCTGCAGGCCAAGTGCCAAAGGGAAGAGGAACAAGGGAGGCAGAAAGAAACGGAGCAAGCC
CTCCTCCAGCGAGGAAGATGAGGGCCCAGGAGACAAGCAGGAGAAGGCAACCCAGCGACGTCCGCATGGCCGGGAGCGGCGGGTGGCCTC
CAGGGTGTCTTATAAAGAGGAGAGTGGGAGTGATGAGGCTGGCAGCGGCTCTGATTTTGAGCTCTCCAGTGGAGAAGCCTCTGATCCCTC
TGATGAGGATTCCGAACCTGGCCCTCCAAAGCAGAGGAAAGCCCCCGCTCCTCAGAGGACAAAGGCTGGGTCCAAGAGTGCCTCCAGGAC
CCATCGTGGGAGCCATCGTAAGGACCCAAGCTTGCCAGCGGCATCCTCAAGCTCTTCAAGCAGTAAAAGAGGCAAGAAAATGTGCAGCGA
TGGTGAGAAGGCAGAAAAAAGAAGCATAGCTGGTATAGACCAGTGGCTAGAGGTGTTCTGTGAGCAGGAGGAAAAGTGGGTATGTGTAGA
CTGTGTGCACGGTGTGGTGGGCCAGCCTCTGACCTGTTACAAGTACGCCACCAAGCCCATGACCTATGTGGTGGGCATTGACAGTGACGG
CTGGGTCCGAGATGTCACACAGAGGTACGACCCAGTCTGGATGACAGTGACCCGCAAGTGCCGGGTTGATGCTGAGTGGTGGGCCGAGAC
CTTGAGACCATACCAGAGCCCATTTATGGACAGGGAGAAGAAAGAAGACTTGGAGTTTCAGGCTAAACACATGGACCAGCCTTTGCCCAC
TGCCATTGGCTTATATAAGAACCACCCTCTGTATGCCCTGAAGCGGCATCTCCTGAAATATGAGGCCATCTATCCCGAGACAGCTGCCAT
CCTTGGGTATTGTCGTGGAGAAGCGGTCTACTCCAGGGATTGTGTGCACACTCTGCATTCCAGGGACACGTGGCTGAAGAAAGCAAGAGT
GGTGAGGCTTGGAGAAGTACCCTACAAGATGGTGAAAGGCTTTTCTAACCGTGCTCGGAAAGCCCGACTTGCTGAGCCCCAGCTGCGGGA
AGAAAATGACCTGGGCCTGTTTGGCTACTGGCAGACAGAGGAGTATCAGCCCCCAGTGGCCGTGGACGGGAAGGTGCCCCGGAACGAGTT
TGGGAATGTGTACCTCTTCCTGCCCAGCATGATGCCTATTGGCTGTGTCCAGCTGAACCTGCCCAATCTACACCGCGTGGCCCGCAAGCT
GGACATCGACTGTGTCCAGGCCATCACTGGCTTTGATTTCCATGGCGGCTACTCCCATCCCGTGACTGATGGATACATCGTCTGCGAGGA
ATTCAAAGACGTGCTCCTGACTGCCTGGGAAAATGAGCAGGCAGTCATTGAAAGGAAGGAGAAGGAGAAAAAGGAGAAGCGGGCTCTAGG
GAACTGGAAGTTGCTGGCCAAAGGTCTGCTCATCAGGGAGAGGCTGAAGCGTCGCTACGGGCCCAAGAGTGAGGCAGCAGCTCCCCACAC
AGATGCAGGAGGTGGACTCTCTTCTGATGAAGAGGAGGGGACCAGCTCTCAAGCAGAAGCGGCCAGGATACTGGCTGCCTCCTGGCCTCA
AAACCGAGAAGATGAAGAAAAGCAGAAGCTGAAGGGTGGGCCCAAGAAGACCAAAAGGGAAAAGAAAGCAGCAGCTTCCCACCTGTTCCC

>90466_90466_4_TGFBR2-XPC_TGFBR2_chr3_30648469_ENST00000359013_XPC_chr3_14214562_ENST00000449060_length(amino acids)=901AA_BP=31
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDAFEDEKPPKKSLLSKVSQGKRKRGCSHPGGSADGPAKKKVAKVTVKSENLKVIKDEAL
SDGDDLRDFPSDLKKAHHLKRGATMNEDSNEEEEESENDWEEAKTRERSEKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYR
NNICSQPDLHAIGLSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVHIFLLILRALQ
LLTRLVLSLQPIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSE
EDEGPGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEPGPPKQRKAPAPQRTKAGSKSASRTHRGS
HRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCVHGVVGQPLTCYKYATKPMTYVVGIDSDGWVRD
VTQRYDPVWMTVTRKCRVDAEWWAETLRPYQSPFMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAILGYC
RGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQLREENDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVY
LFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKL
LAKGLLIRERLKRRYGPKSEAAAPHTDAGGGLSSDEEEGTSSQAEAARILAASWPQNREDEEKQKLKGGPKKTKREKKAAASHLFPFEQL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TGFBR2-XPC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016847_86634.333333333333336941.0CETN2
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016847_86634.333333333333336904.0CETN2
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016816_94034.333333333333336941.0ERCC2 and GTF2H1
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016816_94034.333333333333336904.0ERCC2 and GTF2H1
TgeneXPCchr3:30648469chr3:14214562ENST00000285021016496_73434.333333333333336941.0RAD23B
TgeneXPCchr3:30648469chr3:14214562ENST00000449060016496_73434.333333333333336904.0RAD23B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TGFBR2-XPC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TGFBR2-XPC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource