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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAZ2A-PTGES3 (FusionGDB2 ID:9048)

Fusion Gene Summary for BAZ2A-PTGES3

check button Fusion gene summary
Fusion gene informationFusion gene name: BAZ2A-PTGES3
Fusion gene ID: 9048
HgeneTgene
Gene symbol

BAZ2A

PTGES3

Gene ID

11176

10728

Gene namebromodomain adjacent to zinc finger domain 2Aprostaglandin E synthase 3
SynonymsTIP5|WALp3P23|TEBP|cPGES
Cytomap

12q13.3

12q13.3|12

Type of geneprotein-codingprotein-coding
Descriptionbromodomain adjacent to zinc finger domain protein 2ATTF-I interacting peptide 5TTF-I-interacting protein 5transcription termination factor I-interacting protein 5prostaglandin E synthase 3Hsp90 co-chaperonecytosolic prostaglandin E synthasecytosolic prostaglandin E2 synthaseprogesterone receptor complex p23prostaglandin E synthase 3 (cytosolic)telomerase-binding protein p23unactive progesterone receptor, 23
Modification date2020031320200313
UniProtAcc

Q9UIF9

.
Ensembl transtripts involved in fusion geneENST00000179765, ENST00000379441, 
ENST00000549884, ENST00000551812, 
ENST00000553222, 		ENST00000262033, 
ENST00000414274, ENST00000436399, 
ENST00000448157, ENST00000456859, 
ENST00000537473, 
Fusion gene scores* DoF score16 X 18 X 8=23048 X 9 X 4=288
# samples 2010
** MAII scorelog2(20/2304*10)=-3.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAZ2A [Title/Abstract] AND PTGES3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAZ2A(57023909)-PTGES3(57060050), # samples:1
BAZ2A(56993747)-PTGES3(57068015), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTGES3

GO:0001516

prostaglandin biosynthetic process

10922363

TgenePTGES3

GO:0007004

telomere maintenance via telomerase

10197982|19740745

TgenePTGES3

GO:0042327

positive regulation of phosphorylation

19740745

TgenePTGES3

GO:0051085

chaperone cofactor-dependent protein refolding

12853476

TgenePTGES3

GO:0051973

positive regulation of telomerase activity

10197982|19740745

TgenePTGES3

GO:1905323

telomerase holoenzyme complex assembly

10197982


check buttonFusion gene breakpoints across BAZ2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PTGES3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5KX-01ABAZ2Achr12

56993747

-PTGES3chr12

57068015

+
ChimerDB4STADTCGA-VQ-A928-01ABAZ2Achr12

57023909

-PTGES3chr12

57060050

-


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Fusion Gene ORF analysis for BAZ2A-PTGES3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000179765ENST00000262033BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000179765ENST00000414274BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000179765ENST00000436399BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000179765ENST00000448157BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000179765ENST00000456859BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000179765ENST00000537473BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000379441ENST00000262033BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000379441ENST00000414274BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000379441ENST00000436399BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000379441ENST00000448157BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000379441ENST00000456859BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000379441ENST00000537473BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000549884ENST00000262033BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000549884ENST00000414274BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000549884ENST00000436399BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000549884ENST00000448157BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000549884ENST00000456859BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000549884ENST00000537473BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000551812ENST00000262033BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000551812ENST00000414274BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000551812ENST00000436399BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000551812ENST00000448157BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000551812ENST00000456859BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5CDS-intronENST00000551812ENST00000537473BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
5UTR-3CDSENST00000549884ENST00000262033BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
5UTR-5UTRENST00000549884ENST00000414274BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
5UTR-5UTRENST00000549884ENST00000436399BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
5UTR-5UTRENST00000549884ENST00000537473BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
5UTR-intronENST00000549884ENST00000448157BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
5UTR-intronENST00000549884ENST00000456859BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-3CDSENST00000179765ENST00000262033BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-3CDSENST00000379441ENST00000262033BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-3CDSENST00000551812ENST00000262033BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-3CDSENST00000553222ENST00000262033BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000179765ENST00000414274BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000179765ENST00000436399BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000179765ENST00000537473BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000379441ENST00000414274BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000379441ENST00000436399BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000379441ENST00000537473BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000551812ENST00000414274BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000551812ENST00000436399BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000551812ENST00000537473BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000553222ENST00000414274BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000553222ENST00000436399BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-5UTRENST00000553222ENST00000537473BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-intronENST00000179765ENST00000448157BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-intronENST00000179765ENST00000456859BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-intronENST00000379441ENST00000448157BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-intronENST00000379441ENST00000456859BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-intronENST00000551812ENST00000448157BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-intronENST00000551812ENST00000456859BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-intronENST00000553222ENST00000262033BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
intron-intronENST00000553222ENST00000414274BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
intron-intronENST00000553222ENST00000436399BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
intron-intronENST00000553222ENST00000448157BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
intron-intronENST00000553222ENST00000448157BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-intronENST00000553222ENST00000456859BAZ2Achr12

56993747

-PTGES3chr12

57068015

+
intron-intronENST00000553222ENST00000456859BAZ2Achr12

57023909

-PTGES3chr12

57060050

-
intron-intronENST00000553222ENST00000537473BAZ2Achr12

56993747

-PTGES3chr12

57068015

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BAZ2A-PTGES3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BAZ2A-PTGES3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57023909/:57060050)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAZ2A

Q9UIF9

.
FUNCTION: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BAZ2A-PTGES3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BAZ2A-PTGES3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAZ2A-PTGES3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAZ2A-PTGES3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource