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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TGFBRAP1-DPP10 (FusionGDB2 ID:90489)

Fusion Gene Summary for TGFBRAP1-DPP10

check button Fusion gene summary
Fusion gene informationFusion gene name: TGFBRAP1-DPP10
Fusion gene ID: 90489
HgeneTgene
Gene symbol

TGFBRAP1

DPP10

Gene ID

9392

57628

Gene nametransforming growth factor beta receptor associated protein 1dipeptidyl peptidase like 10
SynonymsTRAP-1|TRAP1|VPS3DPL2|DPPY|DPRP-3|DPRP3
Cytomap

2q12.1-q12.2

2q14.1

Type of geneprotein-codingprotein-coding
Descriptiontransforming growth factor-beta receptor-associated protein 1TGF-beta receptor-associated protein 1VPS3 CORVET complex subunitinactive dipeptidyl peptidase 10DPP Xdipeptidyl peptidase 10dipeptidyl peptidase IV-related protein 3dipeptidyl peptidase Xdipeptidyl peptidase-like protein 2dipeptidyl-peptidase 10 (inactive)dipeptidyl-peptidase 10 (non-functional)
Modification date2020031320200313
UniProtAcc.

Q8N608

Ensembl transtripts involved in fusion geneENST00000258449, ENST00000393359, 
ENST00000310323, ENST00000393147, 
ENST00000409163, ENST00000410059, 
ENST00000488208, 
Fusion gene scores* DoF score8 X 6 X 5=24012 X 13 X 3=468
# samples 1013
** MAII scorelog2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/468*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TGFBRAP1 [Title/Abstract] AND DPP10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTGFBRAP1(105912813)-DPP10(115464694), # samples:2
TGFBRAP1(105912813)-DPP10(116066815), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTGFBRAP1

GO:0006355

regulation of transcription, DNA-templated

11278302

HgeneTGFBRAP1

GO:0007165

signal transduction

11278302

TgeneDPP10

GO:1903078

positive regulation of protein localization to plasma membrane

15671030


check buttonFusion gene breakpoints across TGFBRAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DPP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A8BU-01ATGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
ChimerDB4SARCTCGA-DX-A8BU-01ATGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
ChimerDB4SARCTCGA-DX-AB2J-01ATGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
ChimerDB4SARCTCGA-DX-AB2J-01ATGFBRAP1chr2

105912813

-DPP10chr2

116066815

+


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Fusion Gene ORF analysis for TGFBRAP1-DPP10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000258449ENST00000310323TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
5CDS-5UTRENST00000258449ENST00000393147TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
5CDS-5UTRENST00000258449ENST00000409163TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
5CDS-5UTRENST00000393359ENST00000310323TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
5CDS-5UTRENST00000393359ENST00000393147TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
5CDS-5UTRENST00000393359ENST00000409163TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
5CDS-intronENST00000258449ENST00000310323TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000258449ENST00000393147TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000258449ENST00000409163TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000258449ENST00000410059TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000258449ENST00000488208TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000258449ENST00000488208TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
5CDS-intronENST00000393359ENST00000310323TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000393359ENST00000393147TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000393359ENST00000409163TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000393359ENST00000410059TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000393359ENST00000488208TGFBRAP1chr2

105912813

-DPP10chr2

115464694

+
5CDS-intronENST00000393359ENST00000488208TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
In-frameENST00000258449ENST00000410059TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+
In-frameENST00000393359ENST00000410059TGFBRAP1chr2

105912813

-DPP10chr2

116066815

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393359TGFBRAP1chr2105912813-ENST00000410059DPP10chr2116066815+7203146528337951170
ENST00000258449TGFBRAP1chr2105912813-ENST00000410059DPP10chr2116066815+679610582033881122

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393359ENST00000410059TGFBRAP1chr2105912813-DPP10chr2116066815+0.0002896950.99971026
ENST00000258449ENST00000410059TGFBRAP1chr2105912813-DPP10chr2116066815+0.0001774030.9998227

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Fusion Genomic Features for TGFBRAP1-DPP10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TGFBRAP1chr2105912812-DPP10chr2116066814+6.59E-080.9999999
TGFBRAP1chr2105912812-DPP10chr2116066814+6.59E-080.9999999
TGFBRAP1chr2105912812-DPP10chr2116066814+6.59E-080.9999999
TGFBRAP1chr2105912812-DPP10chr2116066814+6.59E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TGFBRAP1-DPP10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:105912813/chr2:115464694)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DPP10

Q8N608

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155). {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:15671030}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGFBRAP1chr2:105912813chr2:116066815ENST00000258449-31124_297346861.0DomainCNH
HgeneTGFBRAP1chr2:105912813chr2:116066815ENST00000393359-41224_297346861.0DomainCNH
TgeneDPP10chr2:105912813chr2:116066815ENST000004091631271_560747.0RegionNote=Mediates effects on KCND2
TgeneDPP10chr2:105912813chr2:116066815ENST0000031032302656_79613790.0Topological domainExtracellular
TgeneDPP10chr2:105912813chr2:116066815ENST0000039314702656_79624801.0Topological domainExtracellular
TgeneDPP10chr2:105912813chr2:116066815ENST000004091631271_340747.0Topological domainCytoplasmic
TgeneDPP10chr2:105912813chr2:116066815ENST0000040916312756_7960747.0Topological domainExtracellular
TgeneDPP10chr2:105912813chr2:116066815ENST0000041005902656_79620797.0Topological domainExtracellular
TgeneDPP10chr2:105912813chr2:116066815ENST0000031032302635_5513790.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDPP10chr2:105912813chr2:116066815ENST0000039314702635_5524801.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDPP10chr2:105912813chr2:116066815ENST0000040916312735_550747.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDPP10chr2:105912813chr2:116066815ENST0000041005902635_5520797.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGFBRAP1chr2:105912813chr2:116066815ENST00000258449-311564_728346861.0RepeatNote=CHCR
HgeneTGFBRAP1chr2:105912813chr2:116066815ENST00000393359-412564_728346861.0RepeatNote=CHCR
TgeneDPP10chr2:105912813chr2:116066815ENST000003103230261_5613790.0RegionNote=Mediates effects on KCND2
TgeneDPP10chr2:105912813chr2:116066815ENST000003931470261_5624801.0RegionNote=Mediates effects on KCND2
TgeneDPP10chr2:105912813chr2:116066815ENST000004100590261_5620797.0RegionNote=Mediates effects on KCND2
TgeneDPP10chr2:105912813chr2:116066815ENST000003103230261_3413790.0Topological domainCytoplasmic
TgeneDPP10chr2:105912813chr2:116066815ENST000003931470261_3424801.0Topological domainCytoplasmic
TgeneDPP10chr2:105912813chr2:116066815ENST000004100590261_3420797.0Topological domainCytoplasmic


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Fusion Gene Sequence for TGFBRAP1-DPP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90489_90489_1_TGFBRAP1-DPP10_TGFBRAP1_chr2_105912813_ENST00000258449_DPP10_chr2_116066815_ENST00000410059_length(transcript)=6796nt_BP=1058nt
CAGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTACGCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGC
GCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTACGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGA
GGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACAGCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTG
CGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTCCATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGG
CCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCCTGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCA
AACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGTGCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGG
CTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTACATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCT
ACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAGACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCA
CAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGAGAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCG
ATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACAGAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTG
AAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTTGGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCC
GCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAGGAACATTCCAAAGGAAAAATTTCAGGAACTGGGAAGTAACAGCCCTC
CACAGAGAAACTGGAAGGGAATTGCTATTGCTCTGCTGGTGATTTTAGTTGTATGCTCACTCATCACTATGTCAGTCATCCTCTTAACCC
CAGATGAACTCACAAATTCGTCAGAAACCAGATTGTCTTTGGAAGACCTCTTTAGGAAAGACTTTGTGCTTCACGATCCAGAGGCTCGGT
GGATCAATGATACAGATGTGGTGTATAAAAGCGAGAATGGACATGTCATTAAACTGAATATAGAAACAAATGCTACCACATTATTATTGG
AAAACACAACTTTTGTAACCTTCAAAGCATCAAGACATTCAGTTTCACCAGATTTAAAATATGTCCTTCTGGCATATGATGTCAAACAGA
TTTTTCATTATTCGTATACTGCTTCATATGTGATTTACAACATACACACTAGGGAAGTTTGGGAGTTAAATCCTCCAGAAGTAGAGGACT
CCGTCTTGCAGTACGCGGCCTGGGGTGTCCAAGGGCAGCAGCTGATTTATATTTTTGAAAATAATATCTACTATCAACCTGATATAAAGA
GCAGTTCATTGCGACTGACATCTTCTGGAAAAGAAGAAATAATTTTTAATGGGATTGCTGACTGGTTATATGAAGAGGAACTCCTGCATT
CTCACATCGCCCACTGGTGGTCACCAGATGGAGAAAGACTTGCCTTCCTGATGATAAATGACTCTTTGGTACCCACCATGGTTATCCCTC
GGTTTACTGGAGCGTTGTATCCCAAAGGAAAGCAGTATCCGTATCCTAAGGCAGGTCAAGTGAACCCAACAATAAAATTATATGTTGTAA
ACCTGTATGGACCAACTCACACTTTGGAGCTCATGCCACCTGACAGCTTTAAATCAAGAGAATACTATATCACTATGGTTAAATGGGTAA
GCAATACCAAGACTGTGGTAAGATGGTTAAACCGAGCTCAGAACATCTCCATCCTCACAGTCTGTGAGACCACTACAGGTGCTTGTAGTA
AAAAATATGAGATGACATCAGATACGTGGCTCTCTCAGCAGAATGAGGAGCCCGTGTTTTCTAGAGACGGCAGCAAATTCTTTATGACAG
TGCCTGTTAAGCAAGGGGGACGTGGAGAATTTCACCACGTAGCTATGTTCCTCATCCAGAGTAAAAGTGAGCAAATTACCGTGCGGCATC
TGACATCAGGAAACTGGGAAGTGATAAAGATCTTGGCATACGATGAAACTACTCAAAAAATTTACTTTCTGAGCACTGAATCTTCTCCCA
GAGGAAGGCAGCTGTACAGTGCTTCTACTGAAGGATTATTGAATCGCCAATGCATTTCATGTAATTTCATGAAAGAACAATGTACATATT
TTGATGCCAGTTTTAGTCCCATGAATCAACATTTCTTATTATTCTGTGAAGGTCCAAGGGTCCCAGTGGTCAGCCTACATAGTACGGACA
ACCCAGCAAAATATTTTATATTGGAAAGCAATTCTATGCTGAAGGAAGCTATCCTGAAGAAGAAGATAGGAAAGCCAGAAATTAAAATCC
TTCATATTGACGACTATGAACTTCCTTTACAGTTGTCCCTTCCCAAAGATTTTATGGACCGAAACCAGTATGCTCTTCTGTTAATAATGG
ATGAAGAACCAGGAGGCCAGCTGGTTACAGATAAGTTCCATATTGACTGGGATTCCGTACTCATTGACATGGATAATGTCATTGTAGCAA
GATTTGATGGCAGAGGAAGTGGATTCCAGGGTCTGAAAATTTTGCAGGAGATTCATCGAAGATTAGGTTCAGTAGAAGTAAAGGACCAAA
TAACAGCTGTGAAATTTTTGCTGAAACTGCCTTACATTGACTCCAAAAGATTAAGCATTTTTGGAAAGGGTTATGGTGGCTATATTGCAT
CAATGATCTTAAAATCAGATGAAAAGCTTTTTAAATGTGGATCCGTGGTTGCACCTATCACAGACTTGAAATTGTATGCCTCAGCTTTCT
CTGAAAGATACCTTGGGATGCCATCTAAGGAAGAAAGCACTTACCAGGCAGCCAGTGTGCTACATAATGTTCATGGCTTGAAAGAAGAAA
ATATATTAATAATTCATGGAACTGCTGACACAAAAGTTCATTTCCAACACTCAGCAGAATTAATCAAGCACCTAATAAAAGCTGGAGTGA
ATTATACTATGCAGGTCTACCCAGATGAAGGTCATAACGTATCTGAGAAGAGCAAGTATCATCTCTACAGCACAATCCTCAAATTCTTCA
GTGATTGTTTGAAGGAAGAAATATCTGTGCTACCACAGGAACCAGAAGAAGATGAATAATGGACTGTATTTATACAGAACTGAAGGGAAT
ATTGAGGCTCAATGAAACCTGACAAAGAGACTGTAATATTGTAGTTGCTCCAGAATGTCAAGGGCAGCTTACGGAGATGTCACTGGAGCA
GCACGCTCAGAGACAGTGAACTAGCATTTGAATACACAAGTCCAAGTCTACTGTGTTGCTAGGGGTGCAGAACCCGTTTCTTTGTATGAG
AGAGGTCAAAGGGTTGGTTTCCTGGGAGAAATTAGTTTTGCATTAAAGTAGGAGTAGTGCATGTTTTCTTCTGTTATCCCCCTGTTTGTT
CTGTAACTAGTTGCTCTCATTTTAATTTCACTGGCCACCATCATCTTTGCATATAATGCACAATCTATCATCTGTCCTACAGTCCCTGAT
CTTTCATGGCTGAGCTGCAATCTAACACTTTACTGTACCTTTATAATAAGTGCAATTCTTTCATTGTCTATTATTATGCTTAAGAAAATA
TTCAGTTAATAAAAAACAGAGTATTTTATGTAATTTCTGTTTTTAAAAAGACATTATTAAATGGGTCAAAGGACATATAGAAATGTGGAT
TTCAGCACCTTCCAAAGTTCAGCCAGTTATCAGTAGATACAATATCTTTAAATGAACACACGAGTGTATGTCTCACAATATATATACACA
AGTGTGCATATACAGTTAATGAAACTATCTTTAAATGTTATTCATGCTATAAAGAGTAAACGTTTGATGAATTAGAAGAGATGCTCTTTT
CCAAGCTATAATGGATGCTTTGTTTAATGAGCCAAATATGATGAAACATTTTTTCCAATTCAAATTCTAGCTATTGCTTTCCTATAAATG
TTTGGGTTGTGTTTGGTATTGTTTTTAGTGGTTAATAGTTTTCCAGTTGCATTTAATTTTTTGAATATGATACCTTGTCACATGTAAATT
AGATACTTAAATATTAAATTATAGTTTCTGATAAAGAAATTTTGTTAACAATGCAATGCCACTGAGTGCTATTTTGCTCTTTTGGTGGAG
AAGGCTTTTTTCAAAACTCTTGGTCCTTTTACTTCTTTCTCTCAGTGCAGAATCAATTCTCATTTTCATCGTAAAAGCAAATAGCTGGAT
TATTTCATTTGCCAGTTTCTATTTAGTATTCCATGCCTGCCCAATTCATCTGTTACTGTTTAATTTCAATTCTTCTGGTGAGAATTAGAA
ATGAAATATTTTTTATTCATTGGCCAAAAAGTTCACAGACAGCAGTGTTTGCTATTTACTTTGAATTGAAGGCACAAAATGCATCAATTC
CTGTGCTGTGTTGACTTGCAGTAGTAAGTAACTGAGAGCATAAAATAAACCTGACTGTATGAAGTCAATTTAAGTGATGAGAACATTTAA
CTTTGGTGACTAAAGTCAGAATATCTTCTCACTTCACTTAAGGGATCTTCCAGAAGATATCTAAAAGTCTGTAATAAGCTTAGAAGTTCA
GATAAATCTAGGCAGGATACTGCATTTTTGTGGTTTTAAAAAAGTCCTTAGGACAGACTGAATTATCATAACTTATGGCATCAGGAGGAA
ACTTTAAAATATCAAGGAATCACTCAGTCACCCTCCTGTTTTGTTGAAGGATCAACCCCAAATTCTGGGTATTTGAGTACATGTGAATCA
TGGATTTGGTATTCAACTTTTTCCCTGGATGCTTTGGAATCGTGTCTTCCATGCTCCACTGGGTTCAATTTAAAATAGGAGAGGCTTTCT
CTTCTGAAAGATCCATTTTAGGTCTTTTTCAAGAATAGTGAACACATTTTTTAACAAAATAAGTTGTAATTTTAAAAGGAAAGTTTTGCC
TATTTTATTAAGATGGAAATTTCTTTTTAGGCTAATTTGAAATCCAACTGAAGCTTTTTAACCAATATTTTAAATTTGAACCACTAGAGT
TTTTTATGATGCAAATGATTATGTTGTCTGAAAGGTGTGGTTTTATTGAATGTCTATTTGAGTATCATTTAAAAAGTATTTGCCTTTTAC
TGTCATCATTTCTCTTGTTTTATTATTATTATCAATGTTTATCTATTTTTCAATTAATTTAATACAGTTTCTAATGTGAAAGACATTTTT
CTGGAACCCGTTTTCCCCTTAAACACTAAAGAGACCTCAAGTGAAAGCATATTGCTTAGTAGGAAGGTAGAAAATGTTAATCCCTGCGAT
TCTTTGAGTTTTAATGACAGGGTCATTTTCAGTAAAGGAAATGCTCACCAACACATAGTCACCAACTATTAAAGGAATCATGTGATTGGA
TTTTCCCCTGTATACATGTACCCTTGGTCATAATCCCACTATTTCATACATATTTATGCATTGCTAGATTTTCCTAGGACTCCAATAGCA
TGCTTTCCAAGTGTTATTATTCCCTTAATGTTAAAGAAAAAAATCAATATATTGAATTCTTTAATTAAATAGGTAAGCAGTATTAAATCA
TCCACAGAGATAAACAATCTCTTGAAACTCTTTTGAAAGAGAAAAGTGTTTGTTCACTTTCATTGCCTTCATTAAGATCTCCAAATACTC
AGAGACTAAGCAGGCTATTCTCATCTCTTTGAGTTTCCTGACAGAACTAAAGGAAGGAATCACTCTTCAAAAGATGGATCTCACTTCACT
CTGAAAATGTGCCTTTTTTTAATTGGGTGTTTAGCATAAAAATCACTATTGGGGATCTTACAGATGTCTGTTGTAGATCTATTACAATGA
GGTGACTTAGACATTGGGCTTTACCATATTAGAGAATTACTTAAGCCATTGTCCTTCAAATGTTGGGCTTGGAGACAGAAGTACCTTGGA
CTGAATTGCTTTCAAGTCTCTAGAATCACTGACAGCACATAGCTTCTATGAGGAGTTATATATGAAATACCACTTGTGTCCCTCCTCAAG
TTCTCTGACCACCTTCACATCCTGCGGCCACCAACACTGTATGGATACAATCTGGCCTCTCAGCTCTGCTCACTTTCACTTTCTGTTCTG
GGGATTCTCTGATACTAATTTTGGCTACTTGGTAGAACCAAGAGACAAATCGCTTACATGCTGCAAACCGATGTGAAGGTGTTACTAACC
CGCTAAAACACAATTAATGAAAGACTGTAGCAGGTAACTGATCTTTCCCTCAGATATTCTACATGGTCCATGGAAGACTCTGTGGGCCGC
AGAAGCCCATAGCTGCATACCCTTCTATTTTCCTCTTCCCCATTTCACTCTTTTAAGCTCCCTACTCCTATTCCCTATGATCACTTTCCA
AAATAAACGGCAGGTGTGCTAGCTGTTGTCTTAGACTCTGCTTTCTGGAAACTATTTTTCCCCTCCACAAGAAATTATCACTGTGAATAT

>90489_90489_1_TGFBRAP1-DPP10_TGFBRAP1_chr2_105912813_ENST00000258449_DPP10_chr2_116066815_ENST00000410059_length(amino acids)=1122AA_BP=346
MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNR
LLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFL
CLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITV
HSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQELGSNSPPQRNWKG
IAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVT
FKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLT
SSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTH
TLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGG
RGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSP
MNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQ
LVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSD
EKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVY

--------------------------------------------------------------
>90489_90489_2_TGFBRAP1-DPP10_TGFBRAP1_chr2_105912813_ENST00000393359_DPP10_chr2_116066815_ENST00000410059_length(transcript)=7203nt_BP=1465nt
CCCGCAGCGGCGGGGGCGGAGAAGAGACCTCAGCCCCGCGGGCTCGCACAGCTGGCGCGGACCACGCTCTCGCCCGGGGCCGGCGGCCTC
AGCGCCCCCCGAATGAACACCTTCCGCCCGCTGGCCGCCCCGCGAGGCGGGCCGTGTCGTGGCCCCGGTGCACGGAGGGGGACGCCGAGG
CCCGGAGCAGGGCCCGTCTCGGCCTGTGCTCGGAGCCAGGCGGCAGGGCCCGCGGGCCGGCGGGCGGCGCGGAGACGGCTGCGCTCCCGC
CCTCCGCCAGCGCCTGGCGGCCGCCCCACGTGACGGGAAGCGGCGGCTGCGGGGTCGGGCCAGCCCAGGAGCCGCGGGCCGGAGCGGGGC
GGCGGGGCCCCAGGCCGCGGGGCGGCGCGGGACGGCGGGCGCCGGCGCCGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTAC
GCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGCGCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTA
CGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGAGGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACA
GCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTGCGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTC
CATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGGCCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCC
TGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCAAACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGT
GCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGGCTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTA
CATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCTACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAG
ACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCACAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGA
GAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCGATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACA
GAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTGAAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTT
GGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCCGCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAG
GAACATTCCAAAGGAAAAATTTCAGGAACTGGGAAGTAACAGCCCTCCACAGAGAAACTGGAAGGGAATTGCTATTGCTCTGCTGGTGAT
TTTAGTTGTATGCTCACTCATCACTATGTCAGTCATCCTCTTAACCCCAGATGAACTCACAAATTCGTCAGAAACCAGATTGTCTTTGGA
AGACCTCTTTAGGAAAGACTTTGTGCTTCACGATCCAGAGGCTCGGTGGATCAATGATACAGATGTGGTGTATAAAAGCGAGAATGGACA
TGTCATTAAACTGAATATAGAAACAAATGCTACCACATTATTATTGGAAAACACAACTTTTGTAACCTTCAAAGCATCAAGACATTCAGT
TTCACCAGATTTAAAATATGTCCTTCTGGCATATGATGTCAAACAGATTTTTCATTATTCGTATACTGCTTCATATGTGATTTACAACAT
ACACACTAGGGAAGTTTGGGAGTTAAATCCTCCAGAAGTAGAGGACTCCGTCTTGCAGTACGCGGCCTGGGGTGTCCAAGGGCAGCAGCT
GATTTATATTTTTGAAAATAATATCTACTATCAACCTGATATAAAGAGCAGTTCATTGCGACTGACATCTTCTGGAAAAGAAGAAATAAT
TTTTAATGGGATTGCTGACTGGTTATATGAAGAGGAACTCCTGCATTCTCACATCGCCCACTGGTGGTCACCAGATGGAGAAAGACTTGC
CTTCCTGATGATAAATGACTCTTTGGTACCCACCATGGTTATCCCTCGGTTTACTGGAGCGTTGTATCCCAAAGGAAAGCAGTATCCGTA
TCCTAAGGCAGGTCAAGTGAACCCAACAATAAAATTATATGTTGTAAACCTGTATGGACCAACTCACACTTTGGAGCTCATGCCACCTGA
CAGCTTTAAATCAAGAGAATACTATATCACTATGGTTAAATGGGTAAGCAATACCAAGACTGTGGTAAGATGGTTAAACCGAGCTCAGAA
CATCTCCATCCTCACAGTCTGTGAGACCACTACAGGTGCTTGTAGTAAAAAATATGAGATGACATCAGATACGTGGCTCTCTCAGCAGAA
TGAGGAGCCCGTGTTTTCTAGAGACGGCAGCAAATTCTTTATGACAGTGCCTGTTAAGCAAGGGGGACGTGGAGAATTTCACCACGTAGC
TATGTTCCTCATCCAGAGTAAAAGTGAGCAAATTACCGTGCGGCATCTGACATCAGGAAACTGGGAAGTGATAAAGATCTTGGCATACGA
TGAAACTACTCAAAAAATTTACTTTCTGAGCACTGAATCTTCTCCCAGAGGAAGGCAGCTGTACAGTGCTTCTACTGAAGGATTATTGAA
TCGCCAATGCATTTCATGTAATTTCATGAAAGAACAATGTACATATTTTGATGCCAGTTTTAGTCCCATGAATCAACATTTCTTATTATT
CTGTGAAGGTCCAAGGGTCCCAGTGGTCAGCCTACATAGTACGGACAACCCAGCAAAATATTTTATATTGGAAAGCAATTCTATGCTGAA
GGAAGCTATCCTGAAGAAGAAGATAGGAAAGCCAGAAATTAAAATCCTTCATATTGACGACTATGAACTTCCTTTACAGTTGTCCCTTCC
CAAAGATTTTATGGACCGAAACCAGTATGCTCTTCTGTTAATAATGGATGAAGAACCAGGAGGCCAGCTGGTTACAGATAAGTTCCATAT
TGACTGGGATTCCGTACTCATTGACATGGATAATGTCATTGTAGCAAGATTTGATGGCAGAGGAAGTGGATTCCAGGGTCTGAAAATTTT
GCAGGAGATTCATCGAAGATTAGGTTCAGTAGAAGTAAAGGACCAAATAACAGCTGTGAAATTTTTGCTGAAACTGCCTTACATTGACTC
CAAAAGATTAAGCATTTTTGGAAAGGGTTATGGTGGCTATATTGCATCAATGATCTTAAAATCAGATGAAAAGCTTTTTAAATGTGGATC
CGTGGTTGCACCTATCACAGACTTGAAATTGTATGCCTCAGCTTTCTCTGAAAGATACCTTGGGATGCCATCTAAGGAAGAAAGCACTTA
CCAGGCAGCCAGTGTGCTACATAATGTTCATGGCTTGAAAGAAGAAAATATATTAATAATTCATGGAACTGCTGACACAAAAGTTCATTT
CCAACACTCAGCAGAATTAATCAAGCACCTAATAAAAGCTGGAGTGAATTATACTATGCAGGTCTACCCAGATGAAGGTCATAACGTATC
TGAGAAGAGCAAGTATCATCTCTACAGCACAATCCTCAAATTCTTCAGTGATTGTTTGAAGGAAGAAATATCTGTGCTACCACAGGAACC
AGAAGAAGATGAATAATGGACTGTATTTATACAGAACTGAAGGGAATATTGAGGCTCAATGAAACCTGACAAAGAGACTGTAATATTGTA
GTTGCTCCAGAATGTCAAGGGCAGCTTACGGAGATGTCACTGGAGCAGCACGCTCAGAGACAGTGAACTAGCATTTGAATACACAAGTCC
AAGTCTACTGTGTTGCTAGGGGTGCAGAACCCGTTTCTTTGTATGAGAGAGGTCAAAGGGTTGGTTTCCTGGGAGAAATTAGTTTTGCAT
TAAAGTAGGAGTAGTGCATGTTTTCTTCTGTTATCCCCCTGTTTGTTCTGTAACTAGTTGCTCTCATTTTAATTTCACTGGCCACCATCA
TCTTTGCATATAATGCACAATCTATCATCTGTCCTACAGTCCCTGATCTTTCATGGCTGAGCTGCAATCTAACACTTTACTGTACCTTTA
TAATAAGTGCAATTCTTTCATTGTCTATTATTATGCTTAAGAAAATATTCAGTTAATAAAAAACAGAGTATTTTATGTAATTTCTGTTTT
TAAAAAGACATTATTAAATGGGTCAAAGGACATATAGAAATGTGGATTTCAGCACCTTCCAAAGTTCAGCCAGTTATCAGTAGATACAAT
ATCTTTAAATGAACACACGAGTGTATGTCTCACAATATATATACACAAGTGTGCATATACAGTTAATGAAACTATCTTTAAATGTTATTC
ATGCTATAAAGAGTAAACGTTTGATGAATTAGAAGAGATGCTCTTTTCCAAGCTATAATGGATGCTTTGTTTAATGAGCCAAATATGATG
AAACATTTTTTCCAATTCAAATTCTAGCTATTGCTTTCCTATAAATGTTTGGGTTGTGTTTGGTATTGTTTTTAGTGGTTAATAGTTTTC
CAGTTGCATTTAATTTTTTGAATATGATACCTTGTCACATGTAAATTAGATACTTAAATATTAAATTATAGTTTCTGATAAAGAAATTTT
GTTAACAATGCAATGCCACTGAGTGCTATTTTGCTCTTTTGGTGGAGAAGGCTTTTTTCAAAACTCTTGGTCCTTTTACTTCTTTCTCTC
AGTGCAGAATCAATTCTCATTTTCATCGTAAAAGCAAATAGCTGGATTATTTCATTTGCCAGTTTCTATTTAGTATTCCATGCCTGCCCA
ATTCATCTGTTACTGTTTAATTTCAATTCTTCTGGTGAGAATTAGAAATGAAATATTTTTTATTCATTGGCCAAAAAGTTCACAGACAGC
AGTGTTTGCTATTTACTTTGAATTGAAGGCACAAAATGCATCAATTCCTGTGCTGTGTTGACTTGCAGTAGTAAGTAACTGAGAGCATAA
AATAAACCTGACTGTATGAAGTCAATTTAAGTGATGAGAACATTTAACTTTGGTGACTAAAGTCAGAATATCTTCTCACTTCACTTAAGG
GATCTTCCAGAAGATATCTAAAAGTCTGTAATAAGCTTAGAAGTTCAGATAAATCTAGGCAGGATACTGCATTTTTGTGGTTTTAAAAAA
GTCCTTAGGACAGACTGAATTATCATAACTTATGGCATCAGGAGGAAACTTTAAAATATCAAGGAATCACTCAGTCACCCTCCTGTTTTG
TTGAAGGATCAACCCCAAATTCTGGGTATTTGAGTACATGTGAATCATGGATTTGGTATTCAACTTTTTCCCTGGATGCTTTGGAATCGT
GTCTTCCATGCTCCACTGGGTTCAATTTAAAATAGGAGAGGCTTTCTCTTCTGAAAGATCCATTTTAGGTCTTTTTCAAGAATAGTGAAC
ACATTTTTTAACAAAATAAGTTGTAATTTTAAAAGGAAAGTTTTGCCTATTTTATTAAGATGGAAATTTCTTTTTAGGCTAATTTGAAAT
CCAACTGAAGCTTTTTAACCAATATTTTAAATTTGAACCACTAGAGTTTTTTATGATGCAAATGATTATGTTGTCTGAAAGGTGTGGTTT
TATTGAATGTCTATTTGAGTATCATTTAAAAAGTATTTGCCTTTTACTGTCATCATTTCTCTTGTTTTATTATTATTATCAATGTTTATC
TATTTTTCAATTAATTTAATACAGTTTCTAATGTGAAAGACATTTTTCTGGAACCCGTTTTCCCCTTAAACACTAAAGAGACCTCAAGTG
AAAGCATATTGCTTAGTAGGAAGGTAGAAAATGTTAATCCCTGCGATTCTTTGAGTTTTAATGACAGGGTCATTTTCAGTAAAGGAAATG
CTCACCAACACATAGTCACCAACTATTAAAGGAATCATGTGATTGGATTTTCCCCTGTATACATGTACCCTTGGTCATAATCCCACTATT
TCATACATATTTATGCATTGCTAGATTTTCCTAGGACTCCAATAGCATGCTTTCCAAGTGTTATTATTCCCTTAATGTTAAAGAAAAAAA
TCAATATATTGAATTCTTTAATTAAATAGGTAAGCAGTATTAAATCATCCACAGAGATAAACAATCTCTTGAAACTCTTTTGAAAGAGAA
AAGTGTTTGTTCACTTTCATTGCCTTCATTAAGATCTCCAAATACTCAGAGACTAAGCAGGCTATTCTCATCTCTTTGAGTTTCCTGACA
GAACTAAAGGAAGGAATCACTCTTCAAAAGATGGATCTCACTTCACTCTGAAAATGTGCCTTTTTTTAATTGGGTGTTTAGCATAAAAAT
CACTATTGGGGATCTTACAGATGTCTGTTGTAGATCTATTACAATGAGGTGACTTAGACATTGGGCTTTACCATATTAGAGAATTACTTA
AGCCATTGTCCTTCAAATGTTGGGCTTGGAGACAGAAGTACCTTGGACTGAATTGCTTTCAAGTCTCTAGAATCACTGACAGCACATAGC
TTCTATGAGGAGTTATATATGAAATACCACTTGTGTCCCTCCTCAAGTTCTCTGACCACCTTCACATCCTGCGGCCACCAACACTGTATG
GATACAATCTGGCCTCTCAGCTCTGCTCACTTTCACTTTCTGTTCTGGGGATTCTCTGATACTAATTTTGGCTACTTGGTAGAACCAAGA
GACAAATCGCTTACATGCTGCAAACCGATGTGAAGGTGTTACTAACCCGCTAAAACACAATTAATGAAAGACTGTAGCAGGTAACTGATC
TTTCCCTCAGATATTCTACATGGTCCATGGAAGACTCTGTGGGCCGCAGAAGCCCATAGCTGCATACCCTTCTATTTTCCTCTTCCCCAT
TTCACTCTTTTAAGCTCCCTACTCCTATTCCCTATGATCACTTTCCAAAATAAACGGCAGGTGTGCTAGCTGTTGTCTTAGACTCTGCTT
TCTGGAAACTATTTTTCCCCTCCACAAGAAATTATCACTGTGAATATTACAGGAGGAGAAATAAAATAAGAATAAATCAGTGGTTTATTT

>90489_90489_2_TGFBRAP1-DPP10_TGFBRAP1_chr2_105912813_ENST00000393359_DPP10_chr2_116066815_ENST00000410059_length(amino acids)=1170AA_BP=394
MAAAPRDGKRRLRGRASPGAAGRSGAAGPQAAGRRGTAGAGAADQPVDMMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTN
DCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGD
PFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFL
LAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLP
LEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFR
KDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTRE
VWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMI
NDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISIL
TVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQ
KIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAIL
KKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIH
RRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAAS
VLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE

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Fusion Gene PPI Analysis for TGFBRAP1-DPP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TGFBRAP1-DPP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TGFBRAP1-DPP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource