Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TGFBRAP1-RQCD1 (FusionGDB2 ID:90494)

Fusion Gene Summary for TGFBRAP1-RQCD1

Fusion gene summary

Fusion gene information	Fusion gene name: TGFBRAP1-RQCD1
	Fusion gene ID: 90494
		Hgene	Tgene
	Gene symbol	TGFBRAP1	RQCD1
	Gene ID	9392	9125
	Gene name	transforming growth factor beta receptor associated protein 1	CCR4-NOT transcription complex subunit 9
	Synonyms	TRAP-1\|TRAP1\|VPS3	CAF40\|CT129\|RCD-1\|RCD1\|RQCD1
	Cytomap	2q12.1-q12.2	2q35
	Type of gene	protein-coding	protein-coding
	Description	transforming growth factor-beta receptor-associated protein 1TGF-beta receptor-associated protein 1VPS3 CORVET complex subunit	CCR4-NOT transcription complex subunit 9RCD1 required for cell differentiation1 homologcancer/testis antigen 129cell differentiation protein RCD1 homologcell differentiation protein RQCD1 homologprotein involved in sexual development
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000258449, ENST00000393359,	ENST00000489687, ENST00000273064, ENST00000295701, ENST00000509807, ENST00000542068,
Fusion gene scores	* DoF score	8 X 6 X 5=240	2 X 2 X 2=8
	# samples	10	2
	** MAII score	log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: TGFBRAP1 [Title/Abstract] AND RQCD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TGFBRAP1(105912813)-RQCD1(219447694), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TGFBRAP1	GO:0006355	regulation of transcription, DNA-templated	11278302
Hgene	TGFBRAP1	GO:0007165	signal transduction	11278302
Tgene	RQCD1	GO:2000327	positive regulation of nuclear receptor transcription coactivator activity	18180299

Fusion gene breakpoints across TGFBRAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RQCD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-1505-01A	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+

Top

Fusion Gene ORF analysis for TGFBRAP1-RQCD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000258449	ENST00000489687	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+
5CDS-intron	ENST00000393359	ENST00000489687	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+
In-frame	ENST00000258449	ENST00000273064	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+
In-frame	ENST00000258449	ENST00000295701	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+
In-frame	ENST00000258449	ENST00000509807	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+
In-frame	ENST00000258449	ENST00000542068	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+
In-frame	ENST00000393359	ENST00000273064	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+
In-frame	ENST00000393359	ENST00000295701	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+
In-frame	ENST00000393359	ENST00000509807	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+
In-frame	ENST00000393359	ENST00000542068	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393359	TGFBRAP1	chr2	105912813	-	ENST00000509807	RQCD1	chr2	219447694	+	2507	1465	283	2256	657
ENST00000393359	TGFBRAP1	chr2	105912813	-	ENST00000273064	RQCD1	chr2	219447694	+	4965	1465	283	2160	625
ENST00000393359	TGFBRAP1	chr2	105912813	-	ENST00000542068	RQCD1	chr2	219447694	+	4273	1465	283	2160	625
ENST00000393359	TGFBRAP1	chr2	105912813	-	ENST00000295701	RQCD1	chr2	219447694	+	2310	1465	283	2037	584
ENST00000258449	TGFBRAP1	chr2	105912813	-	ENST00000509807	RQCD1	chr2	219447694	+	2100	1058	20	1849	609
ENST00000258449	TGFBRAP1	chr2	105912813	-	ENST00000273064	RQCD1	chr2	219447694	+	4558	1058	20	1753	577
ENST00000258449	TGFBRAP1	chr2	105912813	-	ENST00000542068	RQCD1	chr2	219447694	+	3866	1058	20	1753	577
ENST00000258449	TGFBRAP1	chr2	105912813	-	ENST00000295701	RQCD1	chr2	219447694	+	1903	1058	20	1630	536

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393359	ENST00000509807	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+	0.00628484	0.9937151
ENST00000393359	ENST00000273064	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+	0.002177955	0.99782205
ENST00000393359	ENST00000542068	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+	0.002981674	0.99701834
ENST00000393359	ENST00000295701	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+	0.002349796	0.9976502
ENST00000258449	ENST00000509807	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+	0.004359695	0.9956403
ENST00000258449	ENST00000273064	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+	0.001658056	0.9983419
ENST00000258449	ENST00000542068	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+	0.002123684	0.9978763
ENST00000258449	ENST00000295701	TGFBRAP1	chr2	105912813	-	RQCD1	chr2	219447694	+	0.001644583	0.99835545

Top

Fusion Genomic Features for TGFBRAP1-RQCD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TGFBRAP1	chr2	105912812	-	RQCD1	chr2	219447693	+	2.67E-06	0.9999974
TGFBRAP1	chr2	105912812	-	RQCD1	chr2	219447693	+	2.67E-06	0.9999974

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for TGFBRAP1-RQCD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:105912813/chr2:219447694)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TGFBRAP1

chr2:105912813

chr2:219447694

ENST00000258449

24_297

346

861.0

Domain

CNH

Hgene

TGFBRAP1

chr2:105912813

chr2:219447694

ENST00000393359

24_297

346

861.0

Domain

CNH

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TGFBRAP1

chr2:105912813

chr2:219447694

ENST00000258449

564_728

346

861.0

Repeat

Note=CHCR

Hgene

TGFBRAP1

chr2:105912813

chr2:219447694

ENST00000393359

564_728

346

861.0

Repeat

Note=CHCR

Top

Fusion Gene Sequence for TGFBRAP1-RQCD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>90494_90494_1_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000258449_RQCD1_chr2_219447694_ENST00000273064_length(transcript)=4558nt_BP=1058nt
CAGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTACGCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGC
GCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTACGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGA
GGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACAGCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTG
CGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTCCATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGG
CCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCCTGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCA
AACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGTGCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGG
CTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTACATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCT
ACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAGACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCA
CAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGAGAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCG
ATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACAGAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTG
AAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTTGGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCC
GCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAGGAACATTCCAAAGGAAAAATTTCAGGAAATTGTAAATATTTATCCAT
CTATCAACCCACCCACCTTGACAGCACACCAGTCTAACAGAGTTTGCAATGCTCTGGCATTACTGCAATGTGTAGCATCACATCCAGAAA
CCAGGTCAGCGTTTCTCGCAGCACACATCCCACTTTTTTTGTACCCCTTTTTGCACACTGTCAGCAAAACACGTCCCTTTGAGTATCTCC
GGCTCACCAGCCTTGGAGTTATTGGGGCCCTGGTGAAAACAGATGAACAAGAAGTAATCAACTTTTTATTAACAACAGAAATTATCCCTT
TATGTTTGCGAATTATGGAATCTGGAAGTGAACTTTCTAAAACAGTTGCCACATTCATCCTCCAGAAGATCTTGTTAGATGACACTGGTT
TGGCTTATATATGTCAGACGTATGAGCGTTTCTCCCATGTTGCCATGATCTTGGGTAAGATGGTCCTGCAGCTATCCAAAGAGCCTTCTG
CCCGTCTGCTGAAGCATGTAGTGAGATGTTACCTTCGACTTTCAGATAACCCCAGGGCACGTGAAGCACTCAGACAGTGCCTCCCTGACC
AGCTGAAAGACACAACCTTCGCCCAGGTGCTAAAAGATGACACCACCACGAAACGCTGGCTTGCACAACTGGTGAAGAACCTGCAAGAGG
GCCAGGTCACCGATCCCCGGGGTATCCCCCTGCCCCCTCAGTGATCCTTCCCTGTTCCCTCCCACTACTCCCCCAAGTTGGGGAAAGGAG
GGGGAACCTACGAGAAAAACAGCTCAGGTTTTATCACCGACTGGGAATAGACAACCTCAATGCTGAACCGCACTGGAGAAAAGGGGCAAG
GTACCCCTGCTGAGGTGTATGGGCTGCCATCTCAGGCTGTCTTGAGGACCTGGGCTCCCTCTGCTACTCCCAGGAAATGGGCTCCTGACA
CAGCAGTCTGCCACCACAGCCCCAGGAGGGTGTCAACACCAGCAAATGCTGTATTTGCAGCATGTCCAAGATGACCCTTCTCCCCTACCT
CTACCTAGCCACTGGCAGGGAGGGGAGACAGTGGTGATAGCAGCAGCACTCTAGGCATGGTGAACGCCTGGGACCAAGCCATGTGGCGTT
TTTTATTTTGCCTTTCTGGAAGACTCAAGATATGTCTCTTCATTCTCTCTCAGTATTTGTTTACTTTGGTTTTTTTGTTTTTAATCTCAG
AGAGAGGTGTGTTTAGTGGGCACAAGCTGTAATATTCAGCAAAACTTTGTCGACTGGCACTGTTTACAAGTCTGTTAGCTGCATAAGCTC
AATAAAAAGTTGGTCTGGGCATTACATCCCCTCTGGCAGGCCAATAGCTGCATCAAGCTGTTGGGAGAAATGGGAGGGCAGGGGAAAGAT
GTAAAGCCAAAGTACAGCAGGAACCCACCACCTGTTTCCCTTCCTTCTCCCATTCTACTCCCAGTCCGGAATGCCACGAGGACCTTAACC
TTGTTTCTGGCTTTAGCTGCTAGTTTTCCCAAATCTCAGTGCTTTCCCTTTTTGAACTTCCCTTCTATTAAACTTAAAACAGATGTCTTA
ATTAATCAGGCTGTCTTGGAAGGGTATTGTATTGGGAGACAAGGGGCGGTGGTGGACCTCACCTTCAATCCAAGTTTTCAAAGATATTTT
CTCAATAACTCTAAAAGGGAGGTGCTTGGGATTAAGGTGACAGTCCACTTGATCCTTTTCTTTGTTTTAGTGTGAATTTCAGCAGCTCCA
TCTGTCTTCATGATTGTACTTGAGCAGTATTAGCTGTATGAGTTAATTTTATTCAGATTGAAGATGGAGGGCTGGGTTCTGCTCACTCAG
TCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGACCATTCTCTTTTAGTCTATGGGAATTACAGGGTTGCCGCTAAAATATTCACTTGTTCA
TATCGTGTCAGAGATTTCCTCTTCTCTGGAGCTTAGGTGGCTCTTCACAATCCATAGGCTTGAATCTGCAACCTAGTGTAAACTGCCTTG
CTTTCCCCGGTTCTTTCCCCTGCTAGCACCTGCTTTCTCATCCCTATCTCCAGTCAAAGATGGGATTGCTTAATCCAACTCTGGAGAGGG
ACCAAGTCTTTTCTGCCCACATCTCACACAATTGAGGTGTCTGAACAAGCTTGGGGAGGGTCTATAAGGGGTAGGCTCAAAAAAAAAAAA
ACCCATTTGCAGAGGCAGTTTTGCCAACACAAGGGCTCTTTCAAGCCGACTTTCACAAAGAGAGCCGGACTTGTTAGTTGGCTTCTGTCT
CTTTAGAGCCAAGAAAATAGTAATTAAGTGGCCTAGATATAGGAAGGGCAGAATAAGCACTTACTCCCCCTGCCTTCCAAGATGAAGAGG
AGAAGCAGGCCAACCCTCAATAATTGCAAGCCTGAAGAGAAGTGATCTTAGAGAAAGCAGAGAACAGAATGGACTGGATAGACATCTTGA
CTCTATTCAGCCCGTAGTCTGTGATCTGGAGAGTCCAGTTAAGGTAACCCAGATTTTTGACAACCGCCTTCCTGCTGAGCCAAAGTTTTC
TCATTACCCCTCCACTGGGGAAGCAGCTGAGGCCCAGGGCCTTGCTCCCTGGGAAATTCTCTTCTCTCCATCTTTCGGTGCATTGGCCAT
GTTACTGTGCCAAAGTGTCTTAATTCTTGTCCCATCTATTCTCAGCTGGCCTTGGAACCCACATAGGAGTTGGTGGGGGAGGGATGGAAT
GGGTATTATTCATTGTAGTTGATCCTGGTGTGTGTATTATATAAAGAGACCCCTCCCCTTATTTTGTGTTTTCCATCCCTCTCCCTTAAC
AGGATTGAAATAAAACATGCTTCTGTTTTTGTAAAAATAATTTTTCCTTTACACTGGAGATTTTATTCTATCAGTATATGGGTAACTAGG
CACTTTGGTCAGGTGATCCTTGTCATGCCTGCTTCTCCCCTCTGTCTACCTACACAACACACACACACACACACACACAGCCCTGCTAAG
ATGGCAGTAGTGGTTCTTTTGTGAACATGTTTTTTGGGGAGACTCCATCTGAGGTACAAAAGCTGTTTGGGAGGCTGGGAGGGGGATGAT
GCCCCTTACCTGATAAAAGTATGTTTTACTGGGACAGAACTTCACTCCTGGCCATATTGGCCAGAACTTAGTGCCAGTGTAGGGAGAGAC
TTCCATAGTGACAAGGTAATGCTTGAAACATCTTACGAACTTTGATGTTCATTTCCTCAAGTTCAAGGCTTGGAGCACATCTCCAGGATT
GTTTCCATGCCTGGCTGTCAGTGGGACACAGCTGCCCTATGCTTCCACGTTCTTTTTTCAAGAGCCTTAGAGGGCCTGTGGCCTGTTTCA
CTGGTGGAACAGGAGCAGCATTGGTAGCCTTCAGAGCATGCCTTGCTTACTAACTACATATTATTCCTCTGCTCATTGTTCCTGCTGCTT

>90494_90494_1_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000258449_RQCD1_chr2_219447694_ENST00000273064_length(amino acids)=577AA_BP=344
MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNR
LLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFL
CLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITV
HSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQEIVNIYPSINPPTL
TAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIME
SGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTF

--------------------------------------------------------------
>90494_90494_2_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000258449_RQCD1_chr2_219447694_ENST00000295701_length(transcript)=1903nt_BP=1058nt
CAGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTACGCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGC
GCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTACGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGA
GGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACAGCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTG
CGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTCCATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGG
CCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCCTGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCA
AACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGTGCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGG
CTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTACATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCT
ACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAGACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCA
CAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGAGAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCG
ATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACAGAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTG
AAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTTGGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCC
GCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAGGAACATTCCAAAGGAAAAATTTCAGGAAATTGTAAATATTTATCCAT
CTATCAACCCACCCACCTTGACAGCACACCAGTCTAACAGAGTTTGCAATGCTCTGGCATTACTGCAATGTGTAGCATCACATCCAGAAA
CCAGGTCAGCGTTTCTCGCAGCACACATCCCACTTTTTTTGTACCCCTTTTTGCACACTGTCAGCAAAACACGTCCCTTTGAGTATCTCC
GGCTCACCAGCCTTGGAGTTATTGGGGCCCTGGTGAAAACAGATGAACAAGAAGTAATCAACTTTTTATTAACAACAGAAATTATCCCTT
TATGTTTGCGAATTATGGAATCTGGAAGTGAACTTTCTAAAACAGTTGCCACATTCATCCTCCAGAAGATCTTGTTAGATGACACTGGTT
TGGCTTATATATGTCAGACGTATGAGCGTTTCTCCCATGTTGCCATGATCTTGGGTAAGATGGTCCTGCAGCTATCCAAAGAGCCTTCTG
CCCGTCTGCTGAAGCATGTAGTGAGATGTTACCTTCGACTTTCAGATAACCCCAGGTTTTCAGATTTGACTTTCTGCTGGTCATCTTTTC
AAAGAAAATGAAACGTTTAAAAGTTCATCTGATAATACTGCTACCATAGTTTTGTTTTCACTGCTCATCTCTTATTAAGGTTTTTAACCA
TAAAACTGAAGCAATTTCTGTAAAGACACAAATTGATAACTTAGTATAGAATTAAAATTCATTAAGTTATCATAAGTTTGATGATATCCT
TGTTAATGTACTGATTTTTGAATTATTTTATTTGCCATAATCCATATATTTCTAACATGAGTATTTTGACAGTATTTAATAAATCAGAAA

>90494_90494_2_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000258449_RQCD1_chr2_219447694_ENST00000295701_length(amino acids)=536AA_BP=344
MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNR
LLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFL
CLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITV
HSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQEIVNIYPSINPPTL
TAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIME

--------------------------------------------------------------
>90494_90494_3_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000258449_RQCD1_chr2_219447694_ENST00000509807_length(transcript)=2100nt_BP=1058nt
CAGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTACGCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGC
GCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTACGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGA
GGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACAGCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTG
CGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTCCATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGG
CCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCCTGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCA
AACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGTGCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGG
CTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTACATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCT
ACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAGACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCA
CAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGAGAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCG
ATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACAGAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTG
AAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTTGGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCC
GCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAGGAACATTCCAAAGGAAAAATTTCAGGAAATTGTAAATATTTATCCAT
CTATCAACCCACCCACCTTGACAGCACACCAGTCTAACAGAGTTTGCAATGCTCTGGCATTACTGCAATGTGTAGCATCACATCCAGAAA
CCAGGTCAGCGTTTCTCGCAGCACACATCCCACTTTTTTTGTACCCCTTTTTGCACACTGTCAGCAAAACACGTCCCTTTGAGTATCTCC
GGCTCACCAGCCTTGGAGTTATTGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGATCTTGAACTCCCGACCTCAAGTGATCTGCCCG
CCTCGGCCTCCCAAAGTGCTGGGATTACAGGGGCCCTGGTGAAAACAGATGAACAAGAAGTAATCAACTTTTTATTAACAACAGAAATTA
TCCCTTTATGTTTGCGAATTATGGAATCTGGAAGTGAACTTTCTAAAACAGTTGCCACATTCATCCTCCAGAAGATCTTGTTAGATGACA
CTGGTTTGGCTTATATATGTCAGACGTATGAGCGTTTCTCCCATGTTGCCATGATCTTGGGTAAGATGGTCCTGCAGCTATCCAAAGAGC
CTTCTGCCCGTCTGCTGAAGCATGTAGTGAGATGTTACCTTCGACTTTCAGATAACCCCAGGGCACGTGAAGCACTCAGACAGTGCCTCC
CTGACCAGCTGAAAGACACAACCTTCGCCCAGGTGCTAAAAGATGACACCACCACGAAACGCTGGCTTGCACAACTGGTGAAGAACCTGC
AAGAGGGCCAGGTCACCGATCCCCGGGGTATCCCCCTGCCCCCTCAGTGATCCTTCCCTGTTCCCTCCCACTACTCCCCCAAGTTGGGGA
AAGGAGGGGGAACCTACGAGAAAAACAGCTCAGGTTTTATCACCGACTGGGAATAGACAACCTCAATGCTGAACCGCACTGGAGAAAAGG
GGCAAGGTACCCCTGCTGAGGTGTATGGGCTGCCATCTCAGGCTGTCTTGAGGACCTGGGCTCCCTCTGCTACTCCCAGGAAATGGGCTC

>90494_90494_3_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000258449_RQCD1_chr2_219447694_ENST00000509807_length(amino acids)=609AA_BP=344
MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNR
LLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFL
CLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITV
HSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQEIVNIYPSINPPTL
TAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIVETGFHHVGQADLELPTSSDLPASASQSA
GITGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLK

--------------------------------------------------------------
>90494_90494_4_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000258449_RQCD1_chr2_219447694_ENST00000542068_length(transcript)=3866nt_BP=1058nt
CAGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTACGCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGC
GCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTACGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGA
GGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACAGCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTG
CGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTCCATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGG
CCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCCTGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCA
AACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGTGCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGG
CTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTACATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCT
ACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAGACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCA
CAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGAGAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCG
ATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACAGAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTG
AAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTTGGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCC
GCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAGGAACATTCCAAAGGAAAAATTTCAGGAAATTGTAAATATTTATCCAT
CTATCAACCCACCCACCTTGACAGCACACCAGTCTAACAGAGTTTGCAATGCTCTGGCATTACTGCAATGTGTAGCATCACATCCAGAAA
CCAGGTCAGCGTTTCTCGCAGCACACATCCCACTTTTTTTGTACCCCTTTTTGCACACTGTCAGCAAAACACGTCCCTTTGAGTATCTCC
GGCTCACCAGCCTTGGAGTTATTGGGGCCCTGGTGAAAACAGATGAACAAGAAGTAATCAACTTTTTATTAACAACAGAAATTATCCCTT
TATGTTTGCGAATTATGGAATCTGGAAGTGAACTTTCTAAAACAGTTGCCACATTCATCCTCCAGAAGATCTTGTTAGATGACACTGGTT
TGGCTTATATATGTCAGACGTATGAGCGTTTCTCCCATGTTGCCATGATCTTGGGTAAGATGGTCCTGCAGCTATCCAAAGAGCCTTCTG
CCCGTCTGCTGAAGCATGTAGTGAGATGTTACCTTCGACTTTCAGATAACCCCAGGGCACGTGAAGCACTCAGACAGTGCCTCCCTGACC
AGCTGAAAGACACAACCTTCGCCCAGGTGCTAAAAGATGACACCACCACGAAACGCTGGCTTGCACAACTGGTGAAGAACCTGCAAGAGG
GCCAGGTCACCGATCCCCGGGGTATCCCCCTGCCCCCTCAGTGATCCTTCCCTGTTCCCTCCCACTACTCCCCCAAGTTGGGGAAAGGAG
GGGGAACCTACGAGAAAAACAGCTCAGGTTTTATCACCGACTGGGAATAGACAACCTCAATGCTGAACCGCACTGGAGAAAAGGGGCAAG
GTACCCCTGCTGAGGTGTATGGGCTGCCATCTCAGGCTGTCTTGAGGACCTGGGCTCCCTCTGCTACTCCCAGGAAATGGGCTCCTGACA
CAGCAGTCTGCCACCACAGCCCCAGGAGGGTGTCAACACCAGCAAATGCTGTATTTGCAGCATGTCCAAGATGACCCTTCTCCCCTACCT
CTACCTAGCCACTGGCAGGGAGGGGAGACAGTGGTGATAGCAGCAGCACTCTAGGCATGGTGAACGCCTGGGACCAAGCCATGTGGCGTT
TTTTATTTTGCCTTTCTGGAAGACTCAAGATATGTCTCTTCATTCTCTCTCAGTATTTGTTTACTTTGGTTTTTTTGTTTTTAATCTCAG
AGAGAGGTGTGTTTAGTGGGCACAAGCTGTAATATTCAGCAAAACTTTGTCGACTGGCACTGTTTACAAGTCTGTTAGCTGCATAAGCTC
AATAAAAAGTTGGTCTGGGCATTACATCCCCTCTGGCAGGCCAATAGCTGCATCAAGCTGTTGGGAGAAATGGGAGGGCAGGGGAAAGAT
GTAAAGCCAAAGTACAGCAGGAACCCACCACCTGTTTCCCTTCCTTCTCCCATTCTACTCCCAGTCCGGAATGCCACGAGGACCTTAACC
TTGTTTCTGGCTTTAGCTGCTAGTTTTCCCAAATCTCAGTGCTTTCCCTTTTTGAACTTCCCTTCTATTAAACTTAAAACAGATGTCTTA
ATTAATCAGGCTGTCTTGGAAGGGTATTGTATTGGGAGACAAGGGGCGGTGGTGGACCTCACCTTCAATCCAAGTTTTCAAAGATATTTT
CTCAATAACTCTAAAAGGGAGGTGCTTGGGATTAAGGTGACAGTCCACTTGATCCTTTTCTTTGTTTTAGTGTGAATTTCAGCAGCTCCA
TCTGTCTTCATGATTGTACTTGAGCAGTATTAGCTGTATGAGTTAATTTTATTCAGATTGAAGATGGAGGGCTGGGTTCTGCTCACTCAG
TCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGACCATTCTCTTTTAGTCTATGGGAATTACAGGGTTGCCGCTAAAATATTCACTTGTTCA
TATCGTGTCAGAGATTTCCTCTTCTCTGGAGCTTAGGTGGCTCTTCACAATCCATAGGCTTGAATCTGCAACCTAGTGTAAACTGCCTTG
CTTTCCCCGGTTCTTTCCCCTGCTAGCACCTGCTTTCTCATCCCTATCTCCAGTCAAAGATGGGATTGCTTAATCCAACTCTGGAGAGGG
ACCAAGTCTTTTCTGCCCACATCTCACACAATTGAGGTGTCTGAACAAGCTTGGGGAGGGTCTATAAGGGGTAGGCTCAAAAAAAAAAAA
ACCCATTTGCAGAGGCAGTTTTGCCAACACAAGGGCTCTTTCAAGCCGACTTTCACAAAGAGAGCCGGACTTGTTAGTTGGCTTCTGTCT
CTTTAGAGCCAAGAAAATAGTAATTAAGTGGCCTAGATATAGGAAGGGCAGAATAAGCACTTACTCCCCCTGCCTTCCAAGATGAAGAGG
AGAAGCAGGCCAACCCTCAATAATTGCAAGCCTGAAGAGAAGTGATCTTAGAGAAAGCAGAGAACAGAATGGACTGGATAGACATCTTGA
CTCTATTCAGCCCGTAGTCTGTGATCTGGAGAGTCCAGTTAAGGTAACCCAGATTTTTGACAACCGCCTTCCTGCTGAGCCAAAGTTTTC
TCATTACCCCTCCACTGGGGAAGCAGCTGAGGCCCAGGGCCTTGCTCCCTGGGAAATTCTCTTCTCTCCATCTTTCGGTGCATTGGCCAT
GTTACTGTGCCAAAGTGTCTTAATTCTTGTCCCATCTATTCTCAGCTGGCCTTGGAACCCACATAGGAGTTGGTGGGGGAGGGATGTGTA

>90494_90494_4_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000258449_RQCD1_chr2_219447694_ENST00000542068_length(amino acids)=577AA_BP=344
MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNR
LLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFL
CLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITV
HSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQEIVNIYPSINPPTL
TAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIME
SGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTF

--------------------------------------------------------------
>90494_90494_5_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000393359_RQCD1_chr2_219447694_ENST00000273064_length(transcript)=4965nt_BP=1465nt
CCCGCAGCGGCGGGGGCGGAGAAGAGACCTCAGCCCCGCGGGCTCGCACAGCTGGCGCGGACCACGCTCTCGCCCGGGGCCGGCGGCCTC
AGCGCCCCCCGAATGAACACCTTCCGCCCGCTGGCCGCCCCGCGAGGCGGGCCGTGTCGTGGCCCCGGTGCACGGAGGGGGACGCCGAGG
CCCGGAGCAGGGCCCGTCTCGGCCTGTGCTCGGAGCCAGGCGGCAGGGCCCGCGGGCCGGCGGGCGGCGCGGAGACGGCTGCGCTCCCGC
CCTCCGCCAGCGCCTGGCGGCCGCCCCACGTGACGGGAAGCGGCGGCTGCGGGGTCGGGCCAGCCCAGGAGCCGCGGGCCGGAGCGGGGC
GGCGGGGCCCCAGGCCGCGGGGCGGCGCGGGACGGCGGGCGCCGGCGCCGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTAC
GCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGCGCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTA
CGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGAGGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACA
GCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTGCGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTC
CATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGGCCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCC
TGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCAAACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGT
GCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGGCTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTA
CATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCTACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAG
ACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCACAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGA
GAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCGATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACA
GAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTGAAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTT
GGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCCGCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAG
GAACATTCCAAAGGAAAAATTTCAGGAAATTGTAAATATTTATCCATCTATCAACCCACCCACCTTGACAGCACACCAGTCTAACAGAGT
TTGCAATGCTCTGGCATTACTGCAATGTGTAGCATCACATCCAGAAACCAGGTCAGCGTTTCTCGCAGCACACATCCCACTTTTTTTGTA
CCCCTTTTTGCACACTGTCAGCAAAACACGTCCCTTTGAGTATCTCCGGCTCACCAGCCTTGGAGTTATTGGGGCCCTGGTGAAAACAGA
TGAACAAGAAGTAATCAACTTTTTATTAACAACAGAAATTATCCCTTTATGTTTGCGAATTATGGAATCTGGAAGTGAACTTTCTAAAAC
AGTTGCCACATTCATCCTCCAGAAGATCTTGTTAGATGACACTGGTTTGGCTTATATATGTCAGACGTATGAGCGTTTCTCCCATGTTGC
CATGATCTTGGGTAAGATGGTCCTGCAGCTATCCAAAGAGCCTTCTGCCCGTCTGCTGAAGCATGTAGTGAGATGTTACCTTCGACTTTC
AGATAACCCCAGGGCACGTGAAGCACTCAGACAGTGCCTCCCTGACCAGCTGAAAGACACAACCTTCGCCCAGGTGCTAAAAGATGACAC
CACCACGAAACGCTGGCTTGCACAACTGGTGAAGAACCTGCAAGAGGGCCAGGTCACCGATCCCCGGGGTATCCCCCTGCCCCCTCAGTG
ATCCTTCCCTGTTCCCTCCCACTACTCCCCCAAGTTGGGGAAAGGAGGGGGAACCTACGAGAAAAACAGCTCAGGTTTTATCACCGACTG
GGAATAGACAACCTCAATGCTGAACCGCACTGGAGAAAAGGGGCAAGGTACCCCTGCTGAGGTGTATGGGCTGCCATCTCAGGCTGTCTT
GAGGACCTGGGCTCCCTCTGCTACTCCCAGGAAATGGGCTCCTGACACAGCAGTCTGCCACCACAGCCCCAGGAGGGTGTCAACACCAGC
AAATGCTGTATTTGCAGCATGTCCAAGATGACCCTTCTCCCCTACCTCTACCTAGCCACTGGCAGGGAGGGGAGACAGTGGTGATAGCAG
CAGCACTCTAGGCATGGTGAACGCCTGGGACCAAGCCATGTGGCGTTTTTTATTTTGCCTTTCTGGAAGACTCAAGATATGTCTCTTCAT
TCTCTCTCAGTATTTGTTTACTTTGGTTTTTTTGTTTTTAATCTCAGAGAGAGGTGTGTTTAGTGGGCACAAGCTGTAATATTCAGCAAA
ACTTTGTCGACTGGCACTGTTTACAAGTCTGTTAGCTGCATAAGCTCAATAAAAAGTTGGTCTGGGCATTACATCCCCTCTGGCAGGCCA
ATAGCTGCATCAAGCTGTTGGGAGAAATGGGAGGGCAGGGGAAAGATGTAAAGCCAAAGTACAGCAGGAACCCACCACCTGTTTCCCTTC
CTTCTCCCATTCTACTCCCAGTCCGGAATGCCACGAGGACCTTAACCTTGTTTCTGGCTTTAGCTGCTAGTTTTCCCAAATCTCAGTGCT
TTCCCTTTTTGAACTTCCCTTCTATTAAACTTAAAACAGATGTCTTAATTAATCAGGCTGTCTTGGAAGGGTATTGTATTGGGAGACAAG
GGGCGGTGGTGGACCTCACCTTCAATCCAAGTTTTCAAAGATATTTTCTCAATAACTCTAAAAGGGAGGTGCTTGGGATTAAGGTGACAG
TCCACTTGATCCTTTTCTTTGTTTTAGTGTGAATTTCAGCAGCTCCATCTGTCTTCATGATTGTACTTGAGCAGTATTAGCTGTATGAGT
TAATTTTATTCAGATTGAAGATGGAGGGCTGGGTTCTGCTCACTCAGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGACCATTCTCTTT
TAGTCTATGGGAATTACAGGGTTGCCGCTAAAATATTCACTTGTTCATATCGTGTCAGAGATTTCCTCTTCTCTGGAGCTTAGGTGGCTC
TTCACAATCCATAGGCTTGAATCTGCAACCTAGTGTAAACTGCCTTGCTTTCCCCGGTTCTTTCCCCTGCTAGCACCTGCTTTCTCATCC
CTATCTCCAGTCAAAGATGGGATTGCTTAATCCAACTCTGGAGAGGGACCAAGTCTTTTCTGCCCACATCTCACACAATTGAGGTGTCTG
AACAAGCTTGGGGAGGGTCTATAAGGGGTAGGCTCAAAAAAAAAAAAACCCATTTGCAGAGGCAGTTTTGCCAACACAAGGGCTCTTTCA
AGCCGACTTTCACAAAGAGAGCCGGACTTGTTAGTTGGCTTCTGTCTCTTTAGAGCCAAGAAAATAGTAATTAAGTGGCCTAGATATAGG
AAGGGCAGAATAAGCACTTACTCCCCCTGCCTTCCAAGATGAAGAGGAGAAGCAGGCCAACCCTCAATAATTGCAAGCCTGAAGAGAAGT
GATCTTAGAGAAAGCAGAGAACAGAATGGACTGGATAGACATCTTGACTCTATTCAGCCCGTAGTCTGTGATCTGGAGAGTCCAGTTAAG
GTAACCCAGATTTTTGACAACCGCCTTCCTGCTGAGCCAAAGTTTTCTCATTACCCCTCCACTGGGGAAGCAGCTGAGGCCCAGGGCCTT
GCTCCCTGGGAAATTCTCTTCTCTCCATCTTTCGGTGCATTGGCCATGTTACTGTGCCAAAGTGTCTTAATTCTTGTCCCATCTATTCTC
AGCTGGCCTTGGAACCCACATAGGAGTTGGTGGGGGAGGGATGGAATGGGTATTATTCATTGTAGTTGATCCTGGTGTGTGTATTATATA
AAGAGACCCCTCCCCTTATTTTGTGTTTTCCATCCCTCTCCCTTAACAGGATTGAAATAAAACATGCTTCTGTTTTTGTAAAAATAATTT
TTCCTTTACACTGGAGATTTTATTCTATCAGTATATGGGTAACTAGGCACTTTGGTCAGGTGATCCTTGTCATGCCTGCTTCTCCCCTCT
GTCTACCTACACAACACACACACACACACACACACAGCCCTGCTAAGATGGCAGTAGTGGTTCTTTTGTGAACATGTTTTTTGGGGAGAC
TCCATCTGAGGTACAAAAGCTGTTTGGGAGGCTGGGAGGGGGATGATGCCCCTTACCTGATAAAAGTATGTTTTACTGGGACAGAACTTC
ACTCCTGGCCATATTGGCCAGAACTTAGTGCCAGTGTAGGGAGAGACTTCCATAGTGACAAGGTAATGCTTGAAACATCTTACGAACTTT
GATGTTCATTTCCTCAAGTTCAAGGCTTGGAGCACATCTCCAGGATTGTTTCCATGCCTGGCTGTCAGTGGGACACAGCTGCCCTATGCT
TCCACGTTCTTTTTTCAAGAGCCTTAGAGGGCCTGTGGCCTGTTTCACTGGTGGAACAGGAGCAGCATTGGTAGCCTTCAGAGCATGCCT
TGCTTACTAACTACATATTATTCCTCTGCTCATTGTTCCTGCTGCTTAAAGGCTAGGAAAAGGGGGATATACAAAGTTGTTGCTTTCAAA

>90494_90494_5_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000393359_RQCD1_chr2_219447694_ENST00000273064_length(amino acids)=625AA_BP=392
MAAAPRDGKRRLRGRASPGAAGRSGAAGPQAAGRRGTAGAGAADQPVDMMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTN
DCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGD
PFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFL
LAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLP
LEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLH
TVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILG

--------------------------------------------------------------
>90494_90494_6_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000393359_RQCD1_chr2_219447694_ENST00000295701_length(transcript)=2310nt_BP=1465nt
CCCGCAGCGGCGGGGGCGGAGAAGAGACCTCAGCCCCGCGGGCTCGCACAGCTGGCGCGGACCACGCTCTCGCCCGGGGCCGGCGGCCTC
AGCGCCCCCCGAATGAACACCTTCCGCCCGCTGGCCGCCCCGCGAGGCGGGCCGTGTCGTGGCCCCGGTGCACGGAGGGGGACGCCGAGG
CCCGGAGCAGGGCCCGTCTCGGCCTGTGCTCGGAGCCAGGCGGCAGGGCCCGCGGGCCGGCGGGCGGCGCGGAGACGGCTGCGCTCCCGC
CCTCCGCCAGCGCCTGGCGGCCGCCCCACGTGACGGGAAGCGGCGGCTGCGGGGTCGGGCCAGCCCAGGAGCCGCGGGCCGGAGCGGGGC
GGCGGGGCCCCAGGCCGCGGGGCGGCGCGGGACGGCGGGCGCCGGCGCCGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTAC
GCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGCGCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTA
CGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGAGGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACA
GCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTGCGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTC
CATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGGCCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCC
TGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCAAACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGT
GCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGGCTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTA
CATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCTACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAG
ACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCACAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGA
GAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCGATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACA
GAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTGAAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTT
GGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCCGCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAG
GAACATTCCAAAGGAAAAATTTCAGGAAATTGTAAATATTTATCCATCTATCAACCCACCCACCTTGACAGCACACCAGTCTAACAGAGT
TTGCAATGCTCTGGCATTACTGCAATGTGTAGCATCACATCCAGAAACCAGGTCAGCGTTTCTCGCAGCACACATCCCACTTTTTTTGTA
CCCCTTTTTGCACACTGTCAGCAAAACACGTCCCTTTGAGTATCTCCGGCTCACCAGCCTTGGAGTTATTGGGGCCCTGGTGAAAACAGA
TGAACAAGAAGTAATCAACTTTTTATTAACAACAGAAATTATCCCTTTATGTTTGCGAATTATGGAATCTGGAAGTGAACTTTCTAAAAC
AGTTGCCACATTCATCCTCCAGAAGATCTTGTTAGATGACACTGGTTTGGCTTATATATGTCAGACGTATGAGCGTTTCTCCCATGTTGC
CATGATCTTGGGTAAGATGGTCCTGCAGCTATCCAAAGAGCCTTCTGCCCGTCTGCTGAAGCATGTAGTGAGATGTTACCTTCGACTTTC
AGATAACCCCAGGTTTTCAGATTTGACTTTCTGCTGGTCATCTTTTCAAAGAAAATGAAACGTTTAAAAGTTCATCTGATAATACTGCTA
CCATAGTTTTGTTTTCACTGCTCATCTCTTATTAAGGTTTTTAACCATAAAACTGAAGCAATTTCTGTAAAGACACAAATTGATAACTTA
GTATAGAATTAAAATTCATTAAGTTATCATAAGTTTGATGATATCCTTGTTAATGTACTGATTTTTGAATTATTTTATTTGCCATAATCC

>90494_90494_6_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000393359_RQCD1_chr2_219447694_ENST00000295701_length(amino acids)=584AA_BP=392
MAAAPRDGKRRLRGRASPGAAGRSGAAGPQAAGRRGTAGAGAADQPVDMMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTN
DCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGD
PFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFL
LAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLP
LEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLH
TVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILG

--------------------------------------------------------------
>90494_90494_7_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000393359_RQCD1_chr2_219447694_ENST00000509807_length(transcript)=2507nt_BP=1465nt
CCCGCAGCGGCGGGGGCGGAGAAGAGACCTCAGCCCCGCGGGCTCGCACAGCTGGCGCGGACCACGCTCTCGCCCGGGGCCGGCGGCCTC
AGCGCCCCCCGAATGAACACCTTCCGCCCGCTGGCCGCCCCGCGAGGCGGGCCGTGTCGTGGCCCCGGTGCACGGAGGGGGACGCCGAGG
CCCGGAGCAGGGCCCGTCTCGGCCTGTGCTCGGAGCCAGGCGGCAGGGCCCGCGGGCCGGCGGGCGGCGCGGAGACGGCTGCGCTCCCGC
CCTCCGCCAGCGCCTGGCGGCCGCCCCACGTGACGGGAAGCGGCGGCTGCGGGGTCGGGCCAGCCCAGGAGCCGCGGGCCGGAGCGGGGC
GGCGGGGCCCCAGGCCGCGGGGCGGCGCGGGACGGCGGGCGCCGGCGCCGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTAC
GCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGCGCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTA
CGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGAGGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACA
GCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTGCGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTC
CATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGGCCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCC
TGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCAAACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGT
GCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGGCTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTA
CATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCTACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAG
ACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCACAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGA
GAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCGATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACA
GAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTGAAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTT
GGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCCGCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAG
GAACATTCCAAAGGAAAAATTTCAGGAAATTGTAAATATTTATCCATCTATCAACCCACCCACCTTGACAGCACACCAGTCTAACAGAGT
TTGCAATGCTCTGGCATTACTGCAATGTGTAGCATCACATCCAGAAACCAGGTCAGCGTTTCTCGCAGCACACATCCCACTTTTTTTGTA
CCCCTTTTTGCACACTGTCAGCAAAACACGTCCCTTTGAGTATCTCCGGCTCACCAGCCTTGGAGTTATTGTAGAGACGGGGTTTCACCA
TGTTGGCCAGGCTGATCTTGAACTCCCGACCTCAAGTGATCTGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGGGCCCTGGTGAA
AACAGATGAACAAGAAGTAATCAACTTTTTATTAACAACAGAAATTATCCCTTTATGTTTGCGAATTATGGAATCTGGAAGTGAACTTTC
TAAAACAGTTGCCACATTCATCCTCCAGAAGATCTTGTTAGATGACACTGGTTTGGCTTATATATGTCAGACGTATGAGCGTTTCTCCCA
TGTTGCCATGATCTTGGGTAAGATGGTCCTGCAGCTATCCAAAGAGCCTTCTGCCCGTCTGCTGAAGCATGTAGTGAGATGTTACCTTCG
ACTTTCAGATAACCCCAGGGCACGTGAAGCACTCAGACAGTGCCTCCCTGACCAGCTGAAAGACACAACCTTCGCCCAGGTGCTAAAAGA
TGACACCACCACGAAACGCTGGCTTGCACAACTGGTGAAGAACCTGCAAGAGGGCCAGGTCACCGATCCCCGGGGTATCCCCCTGCCCCC
TCAGTGATCCTTCCCTGTTCCCTCCCACTACTCCCCCAAGTTGGGGAAAGGAGGGGGAACCTACGAGAAAAACAGCTCAGGTTTTATCAC
CGACTGGGAATAGACAACCTCAATGCTGAACCGCACTGGAGAAAAGGGGCAAGGTACCCCTGCTGAGGTGTATGGGCTGCCATCTCAGGC

>90494_90494_7_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000393359_RQCD1_chr2_219447694_ENST00000509807_length(amino acids)=657AA_BP=392
MAAAPRDGKRRLRGRASPGAAGRSGAAGPQAAGRRGTAGAGAADQPVDMMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTN
DCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGD
PFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFL
LAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLP
LEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLH
TVSKTRPFEYLRLTSLGVIVETGFHHVGQADLELPTSSDLPASASQSAGITGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVA
TFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTT

--------------------------------------------------------------
>90494_90494_8_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000393359_RQCD1_chr2_219447694_ENST00000542068_length(transcript)=4273nt_BP=1465nt
CCCGCAGCGGCGGGGGCGGAGAAGAGACCTCAGCCCCGCGGGCTCGCACAGCTGGCGCGGACCACGCTCTCGCCCGGGGCCGGCGGCCTC
AGCGCCCCCCGAATGAACACCTTCCGCCCGCTGGCCGCCCCGCGAGGCGGGCCGTGTCGTGGCCCCGGTGCACGGAGGGGGACGCCGAGG
CCCGGAGCAGGGCCCGTCTCGGCCTGTGCTCGGAGCCAGGCGGCAGGGCCCGCGGGCCGGCGGGCGGCGCGGAGACGGCTGCGCTCCCGC
CCTCCGCCAGCGCCTGGCGGCCGCCCCACGTGACGGGAAGCGGCGGCTGCGGGGTCGGGCCAGCCCAGGAGCCGCGGGCCGGAGCGGGGC
GGCGGGGCCCCAGGCCGCGGGGCGGCGCGGGACGGCGGGCGCCGGCGCCGCAGATCAGCCAGTAGACATGATGAGCATCAAAGCCTTTAC
GCTTGTCTCTGCTGTGGAGCGGGAGCTGCTGATGGGCGACAAGGAGCGCGTCAACATAGAGTGCGTGGAGTGCTGCGGCAGGGACCTCTA
CGTGGGCACCAACGACTGCTTCGTCTACCACTTCCTGTTGGAGGAGAGGCCAGTGCCTGCTGGGCCAGCCACGTTCACTGCCACCAAACA
GCTGCAGAGACACTTGGGCTTCAAGAAGCCCGTGAACGAGCTGCGTGCGGCCTCAGCACTCAACAGGCTGCTGGTGCTGTGTGACAACTC
CATCAGCCTGGTCAACATGCTGAACCTCGAGCCAGTGCCTTCGGGGGCCCGCATCAAGGGGGCAGCCACGTTTGCACTGAACGAGAACCC
TGTGAGTGGGGACCCCTTCTGTGTAGAAGTTTGCATCATCTCTGTCAAACGCAGAACCATCCAGATGTTTCTGGTGTACGAGGACCGGGT
GCAGATCGTCAAGGAGGTGTCGACTGCCGAGCAGCCCCTCGCTGTGGCTGTGGACGGCCACTTCCTGTGTCTGGCTCTGACCACTCAGTA
CATCATCCACAATTACAGCACAGGCGTCTCCCAGGACCTGTTTCCCTACTGCAGTGAGGAGAGGCCGCCGATCGTCAAGAGGATAGGGAG
ACAGGAGTTCCTGCTGGCGGGCCCCGGAGGGCTGGGCATGTTTGCCACAGTCGCAGGGATATCCCAGCGCGCCCCCGTGCACTGGTCGGA
GAATGTGATTGGGGCGGCTGTGTCCTTTCCATACGTCATAGCGCTCGATGACGAATTCATCACAGTCCACAGCATGTTGGATCAGCAACA
GAAGCAGACGCTGCCCTTTAAGGAGGGCCATATCCTACAGGACTTTGAAGGAAGAGTGATCGTTGCCACAAGTAAAGGAGTTTACATCTT
GGTTCCATTACCTTTGGAAAAACAAATACAGGATCTTCTAGCAAGCCGCAGAGTAGAAGAGGCTTTGGTTTTAGCAAAAGGAGCCCGGAG
GAACATTCCAAAGGAAAAATTTCAGGAAATTGTAAATATTTATCCATCTATCAACCCACCCACCTTGACAGCACACCAGTCTAACAGAGT
TTGCAATGCTCTGGCATTACTGCAATGTGTAGCATCACATCCAGAAACCAGGTCAGCGTTTCTCGCAGCACACATCCCACTTTTTTTGTA
CCCCTTTTTGCACACTGTCAGCAAAACACGTCCCTTTGAGTATCTCCGGCTCACCAGCCTTGGAGTTATTGGGGCCCTGGTGAAAACAGA
TGAACAAGAAGTAATCAACTTTTTATTAACAACAGAAATTATCCCTTTATGTTTGCGAATTATGGAATCTGGAAGTGAACTTTCTAAAAC
AGTTGCCACATTCATCCTCCAGAAGATCTTGTTAGATGACACTGGTTTGGCTTATATATGTCAGACGTATGAGCGTTTCTCCCATGTTGC
CATGATCTTGGGTAAGATGGTCCTGCAGCTATCCAAAGAGCCTTCTGCCCGTCTGCTGAAGCATGTAGTGAGATGTTACCTTCGACTTTC
AGATAACCCCAGGGCACGTGAAGCACTCAGACAGTGCCTCCCTGACCAGCTGAAAGACACAACCTTCGCCCAGGTGCTAAAAGATGACAC
CACCACGAAACGCTGGCTTGCACAACTGGTGAAGAACCTGCAAGAGGGCCAGGTCACCGATCCCCGGGGTATCCCCCTGCCCCCTCAGTG
ATCCTTCCCTGTTCCCTCCCACTACTCCCCCAAGTTGGGGAAAGGAGGGGGAACCTACGAGAAAAACAGCTCAGGTTTTATCACCGACTG
GGAATAGACAACCTCAATGCTGAACCGCACTGGAGAAAAGGGGCAAGGTACCCCTGCTGAGGTGTATGGGCTGCCATCTCAGGCTGTCTT
GAGGACCTGGGCTCCCTCTGCTACTCCCAGGAAATGGGCTCCTGACACAGCAGTCTGCCACCACAGCCCCAGGAGGGTGTCAACACCAGC
AAATGCTGTATTTGCAGCATGTCCAAGATGACCCTTCTCCCCTACCTCTACCTAGCCACTGGCAGGGAGGGGAGACAGTGGTGATAGCAG
CAGCACTCTAGGCATGGTGAACGCCTGGGACCAAGCCATGTGGCGTTTTTTATTTTGCCTTTCTGGAAGACTCAAGATATGTCTCTTCAT
TCTCTCTCAGTATTTGTTTACTTTGGTTTTTTTGTTTTTAATCTCAGAGAGAGGTGTGTTTAGTGGGCACAAGCTGTAATATTCAGCAAA
ACTTTGTCGACTGGCACTGTTTACAAGTCTGTTAGCTGCATAAGCTCAATAAAAAGTTGGTCTGGGCATTACATCCCCTCTGGCAGGCCA
ATAGCTGCATCAAGCTGTTGGGAGAAATGGGAGGGCAGGGGAAAGATGTAAAGCCAAAGTACAGCAGGAACCCACCACCTGTTTCCCTTC
CTTCTCCCATTCTACTCCCAGTCCGGAATGCCACGAGGACCTTAACCTTGTTTCTGGCTTTAGCTGCTAGTTTTCCCAAATCTCAGTGCT
TTCCCTTTTTGAACTTCCCTTCTATTAAACTTAAAACAGATGTCTTAATTAATCAGGCTGTCTTGGAAGGGTATTGTATTGGGAGACAAG
GGGCGGTGGTGGACCTCACCTTCAATCCAAGTTTTCAAAGATATTTTCTCAATAACTCTAAAAGGGAGGTGCTTGGGATTAAGGTGACAG
TCCACTTGATCCTTTTCTTTGTTTTAGTGTGAATTTCAGCAGCTCCATCTGTCTTCATGATTGTACTTGAGCAGTATTAGCTGTATGAGT
TAATTTTATTCAGATTGAAGATGGAGGGCTGGGTTCTGCTCACTCAGTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTGACCATTCTCTTT
TAGTCTATGGGAATTACAGGGTTGCCGCTAAAATATTCACTTGTTCATATCGTGTCAGAGATTTCCTCTTCTCTGGAGCTTAGGTGGCTC
TTCACAATCCATAGGCTTGAATCTGCAACCTAGTGTAAACTGCCTTGCTTTCCCCGGTTCTTTCCCCTGCTAGCACCTGCTTTCTCATCC
CTATCTCCAGTCAAAGATGGGATTGCTTAATCCAACTCTGGAGAGGGACCAAGTCTTTTCTGCCCACATCTCACACAATTGAGGTGTCTG
AACAAGCTTGGGGAGGGTCTATAAGGGGTAGGCTCAAAAAAAAAAAAACCCATTTGCAGAGGCAGTTTTGCCAACACAAGGGCTCTTTCA
AGCCGACTTTCACAAAGAGAGCCGGACTTGTTAGTTGGCTTCTGTCTCTTTAGAGCCAAGAAAATAGTAATTAAGTGGCCTAGATATAGG
AAGGGCAGAATAAGCACTTACTCCCCCTGCCTTCCAAGATGAAGAGGAGAAGCAGGCCAACCCTCAATAATTGCAAGCCTGAAGAGAAGT
GATCTTAGAGAAAGCAGAGAACAGAATGGACTGGATAGACATCTTGACTCTATTCAGCCCGTAGTCTGTGATCTGGAGAGTCCAGTTAAG
GTAACCCAGATTTTTGACAACCGCCTTCCTGCTGAGCCAAAGTTTTCTCATTACCCCTCCACTGGGGAAGCAGCTGAGGCCCAGGGCCTT
GCTCCCTGGGAAATTCTCTTCTCTCCATCTTTCGGTGCATTGGCCATGTTACTGTGCCAAAGTGTCTTAATTCTTGTCCCATCTATTCTC
AGCTGGCCTTGGAACCCACATAGGAGTTGGTGGGGGAGGGATGTGTATTATATAAAGAGACCCCTCCCCTTATTTTGTGTTTTCCATCCC

>90494_90494_8_TGFBRAP1-RQCD1_TGFBRAP1_chr2_105912813_ENST00000393359_RQCD1_chr2_219447694_ENST00000542068_length(amino acids)=625AA_BP=392
MAAAPRDGKRRLRGRASPGAAGRSGAAGPQAAGRRGTAGAGAADQPVDMMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTN
DCFVYHFLLEERPVPAGPATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAATFALNENPVSGD
PFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFLCLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFL
LAGPGGLGMFATVAGISQRAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVATSKGVYILVPLP
LEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLH
TVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TGFBRAP1-RQCD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TGFBRAP1-RQCD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TGFBRAP1-RQCD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source