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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAZ2B-CREB1 (FusionGDB2 ID:9055)

Fusion Gene Summary for BAZ2B-CREB1

check button Fusion gene summary
Fusion gene informationFusion gene name: BAZ2B-CREB1
Fusion gene ID: 9055
HgeneTgene
Gene symbol

BAZ2B

CREB1

Gene ID

29994

1385

Gene namebromodomain adjacent to zinc finger domain 2BcAMP responsive element binding protein 1
SynonymsWALp4CREB|CREB-1
Cytomap

2q24.2

2q33.3

Type of geneprotein-codingprotein-coding
Descriptionbromodomain adjacent to zinc finger domain protein 2Bcyclic AMP-responsive element-binding protein 1active transcription factor CREBcAMP-response element-binding protein-1cyclic adenosine 3',5'-monophosphate response element binding proteincyclic adenosine 3',5'-monophosphate response element-binding pr
Modification date2020031320200315
UniProtAcc

Q9UIF8

P16220

Ensembl transtripts involved in fusion geneENST00000343439, ENST00000355831, 
ENST00000392782, ENST00000392783, 
ENST00000483316, 		ENST00000353267, 
ENST00000430624, ENST00000432329, 
ENST00000374397, ENST00000451164, 
ENST00000536726, ENST00000539789, 
Fusion gene scores* DoF score19 X 14 X 12=31927 X 8 X 4=224
# samples 227
** MAII scorelog2(22/3192*10)=-3.85888522269769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/224*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAZ2B [Title/Abstract] AND CREB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAZ2B(160472753)-CREB1(208461638), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCREB1

GO:0006468

protein phosphorylation

8798441

TgeneCREB1

GO:0010033

response to organic substance

8798441

TgeneCREB1

GO:0010944

negative regulation of transcription by competitive promoter binding

19861239

TgeneCREB1

GO:0045944

positive regulation of transcription by RNA polymerase II

1655749|8798441|19861239


check buttonFusion gene breakpoints across BAZ2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CREB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315469BAZ2Bchr2

160472753

-CREB1chr2

208461638

+


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Fusion Gene ORF analysis for BAZ2B-CREB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000343439ENST00000353267BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000343439ENST00000430624BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000343439ENST00000432329BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000355831ENST00000353267BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000355831ENST00000430624BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000355831ENST00000432329BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000392782ENST00000353267BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000392782ENST00000430624BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000392782ENST00000432329BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000392783ENST00000353267BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000392783ENST00000430624BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000392783ENST00000432329BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000483316ENST00000353267BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000483316ENST00000430624BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-3CDSENST00000483316ENST00000432329BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000343439ENST00000374397BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000343439ENST00000451164BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000343439ENST00000536726BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000343439ENST00000539789BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000355831ENST00000374397BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000355831ENST00000451164BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000355831ENST00000536726BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000355831ENST00000539789BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000392782ENST00000374397BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000392782ENST00000451164BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000392782ENST00000536726BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000392782ENST00000539789BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000392783ENST00000374397BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000392783ENST00000451164BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000392783ENST00000536726BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000392783ENST00000539789BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000483316ENST00000374397BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000483316ENST00000451164BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000483316ENST00000536726BAZ2Bchr2

160472753

-CREB1chr2

208461638

+
5UTR-intronENST00000483316ENST00000539789BAZ2Bchr2

160472753

-CREB1chr2

208461638

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BAZ2B-CREB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BAZ2Bchr2160472752-CREB1chr2208461637+0.0007447140.99925524
BAZ2Bchr2160472752-CREB1chr2208461637+0.0007447140.99925524

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BAZ2B-CREB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:160472753/:208461638)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAZ2B

Q9UIF8

CREB1

P16220

FUNCTION: Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000303|PubMed:10662543}.FUNCTION: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BAZ2B-CREB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BAZ2B-CREB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAZ2B-CREB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAZ2B-CREB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource