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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TG-SLA (FusionGDB2 ID:90553)

Fusion Gene Summary for TG-SLA

check button Fusion gene summary
Fusion gene informationFusion gene name: TG-SLA
Fusion gene ID: 90553
HgeneTgene
Gene symbol

TG

SLA

Gene ID

7038

51091

Gene namethyroglobulinSep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
SynonymsAITD3|TGNLP|PCH2D|SLA|SLA/LP
Cytomap

8q24.22

4p15.2

Type of geneprotein-codingprotein-coding
DescriptionthyroglobulinO-phosphoseryl-tRNA(Sec) selenium transferaseSLA-p35SLA/LP autoantigenUGA suppressor tRNA-associated proteinliver-pancreas antigensoluble liver antigensoluble liver antigen/liver pancreas antigentRNA(Ser/Sec)-associated antigenic protein
Modification date2020031320200313
UniProtAcc.

SLAMF9

Ensembl transtripts involved in fusion geneENST00000220616, ENST00000377869, 
ENST00000519543, ENST00000522523, 
ENST00000542445, 		ENST00000427060, 
ENST00000518565, ENST00000338087, 
ENST00000524345, ENST00000395352, 
ENST00000517648, 
Fusion gene scores* DoF score26 X 22 X 3=17163 X 2 X 3=18
# samples 273
** MAII scorelog2(27/1716*10)=-2.66801824044871
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TG [Title/Abstract] AND SLA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTG(133913798)-SLA(134050982), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-BJ-A192-01ATGchr8

133913798

+SLAchr8

134050982

-
ChimerDB4THCATCGA-BJ-A192TGchr8

133913798

+SLAchr8

134050982

-


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Fusion Gene ORF analysis for TG-SLA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000220616ENST00000427060TGchr8

133913798

+SLAchr8

134050982

-
5CDS-intronENST00000220616ENST00000518565TGchr8

133913798

+SLAchr8

134050982

-
5CDS-intronENST00000377869ENST00000427060TGchr8

133913798

+SLAchr8

134050982

-
5CDS-intronENST00000377869ENST00000518565TGchr8

133913798

+SLAchr8

134050982

-
Frame-shiftENST00000220616ENST00000338087TGchr8

133913798

+SLAchr8

134050982

-
Frame-shiftENST00000220616ENST00000524345TGchr8

133913798

+SLAchr8

134050982

-
Frame-shiftENST00000377869ENST00000338087TGchr8

133913798

+SLAchr8

134050982

-
Frame-shiftENST00000377869ENST00000524345TGchr8

133913798

+SLAchr8

134050982

-
In-frameENST00000220616ENST00000395352TGchr8

133913798

+SLAchr8

134050982

-
In-frameENST00000220616ENST00000517648TGchr8

133913798

+SLAchr8

134050982

-
In-frameENST00000377869ENST00000395352TGchr8

133913798

+SLAchr8

134050982

-
In-frameENST00000377869ENST00000517648TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000519543ENST00000338087TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000519543ENST00000395352TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000519543ENST00000517648TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000519543ENST00000524345TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000522523ENST00000338087TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000522523ENST00000395352TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000522523ENST00000517648TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000522523ENST00000524345TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000542445ENST00000338087TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000542445ENST00000395352TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000542445ENST00000517648TGchr8

133913798

+SLAchr8

134050982

-
intron-3CDSENST00000542445ENST00000524345TGchr8

133913798

+SLAchr8

134050982

-
intron-intronENST00000519543ENST00000427060TGchr8

133913798

+SLAchr8

134050982

-
intron-intronENST00000519543ENST00000518565TGchr8

133913798

+SLAchr8

134050982

-
intron-intronENST00000522523ENST00000427060TGchr8

133913798

+SLAchr8

134050982

-
intron-intronENST00000522523ENST00000518565TGchr8

133913798

+SLAchr8

134050982

-
intron-intronENST00000542445ENST00000427060TGchr8

133913798

+SLAchr8

134050982

-
intron-intronENST00000542445ENST00000518565TGchr8

133913798

+SLAchr8

134050982

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377869TGchr8133913798+ENST00000395352SLAchr8134050982-476036754137181225
ENST00000377869TGchr8133913798+ENST00000517648SLAchr8134050982-398636754137181225
ENST00000220616TGchr8133913798+ENST00000395352SLAchr8134050982-475936744037171225
ENST00000220616TGchr8133913798+ENST00000517648SLAchr8134050982-398536744037171225

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377869ENST00000395352TGchr8133913798+SLAchr8134050982-0.0022767510.9977233
ENST00000377869ENST00000517648TGchr8133913798+SLAchr8134050982-0.0021985070.9978015
ENST00000220616ENST00000395352TGchr8133913798+SLAchr8134050982-0.002252180.99774784
ENST00000220616ENST00000517648TGchr8133913798+SLAchr8134050982-0.0021697910.9978302

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Fusion Genomic Features for TG-SLA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TG-SLA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:133913798/chr8:134050982)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SLA

SLAMF9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.289

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481074_114512112769.0DomainThyroglobulin type-1 9
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481146_121012112769.0DomainThyroglobulin type-1 10
HgeneTGchr8:133913798chr8:134050982ENST00000220616+1648161_29712112769.0DomainThyroglobulin type-1 3
HgeneTGchr8:133913798chr8:134050982ENST00000220616+1648298_35812112769.0DomainThyroglobulin type-1 4
HgeneTGchr8:133913798chr8:134050982ENST00000220616+164831_9212112769.0DomainThyroglobulin type-1 1
HgeneTGchr8:133913798chr8:134050982ENST00000220616+1648605_65812112769.0DomainThyroglobulin type-1 5
HgeneTGchr8:133913798chr8:134050982ENST00000220616+1648659_72612112769.0DomainThyroglobulin type-1 6
HgeneTGchr8:133913798chr8:134050982ENST00000220616+1648727_92112112769.0DomainThyroglobulin type-1 7
HgeneTGchr8:133913798chr8:134050982ENST00000220616+1648922_107312112769.0DomainThyroglobulin type-1 8
HgeneTGchr8:133913798chr8:134050982ENST00000220616+164893_16012112769.0DomainThyroglobulin type-1 2
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471074_114512112712.0DomainThyroglobulin type-1 9
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471146_121012112712.0DomainThyroglobulin type-1 10
HgeneTGchr8:133913798chr8:134050982ENST00000377869+1647161_29712112712.0DomainThyroglobulin type-1 3
HgeneTGchr8:133913798chr8:134050982ENST00000377869+1647298_35812112712.0DomainThyroglobulin type-1 4
HgeneTGchr8:133913798chr8:134050982ENST00000377869+164731_9212112712.0DomainThyroglobulin type-1 1
HgeneTGchr8:133913798chr8:134050982ENST00000377869+1647605_65812112712.0DomainThyroglobulin type-1 5
HgeneTGchr8:133913798chr8:134050982ENST00000377869+1647659_72612112712.0DomainThyroglobulin type-1 6
HgeneTGchr8:133913798chr8:134050982ENST00000377869+1647727_92112112712.0DomainThyroglobulin type-1 7
HgeneTGchr8:133913798chr8:134050982ENST00000377869+1647922_107312112712.0DomainThyroglobulin type-1 8
HgeneTGchr8:133913798chr8:134050982ENST00000377869+164793_16012112712.0DomainThyroglobulin type-1 2
TgeneSLAchr8:133913798chr8:134050982ENST0000033808779212_276205277.0RegionNote=SLA C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481511_156512112769.0DomainThyroglobulin type-1 11
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471511_156512112712.0DomainThyroglobulin type-1 11
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16482188_276812112769.0RegionCholinesterase-like (ChEL)
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16472188_276812112712.0RegionCholinesterase-like (ChEL)
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481456_146912112769.0RepeatType II
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481470_148612112769.0RepeatType II
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481487_150312112769.0RepeatType II
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481603_172312112769.0RepeatType IIIA
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481724_189212112769.0RepeatType IIIB
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481893_199512112769.0RepeatType IIIA
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16481996_212912112769.0RepeatType IIIB
HgeneTGchr8:133913798chr8:134050982ENST00000220616+16482130_218712112769.0RepeatType IIIA
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471456_146912112712.0RepeatType II
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471470_148612112712.0RepeatType II
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471487_150312112712.0RepeatType II
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471603_172312112712.0RepeatType IIIA
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471724_189212112712.0RepeatType IIIB
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471893_199512112712.0RepeatType IIIA
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16471996_212912112712.0RepeatType IIIB
HgeneTGchr8:133913798chr8:134050982ENST00000377869+16472130_218712112712.0RepeatType IIIA
TgeneSLAchr8:133913798chr8:134050982ENST000003380877922_82205277.0DomainSH3
TgeneSLAchr8:133913798chr8:134050982ENST000003380877984_175205277.0DomainSH2


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Fusion Gene Sequence for TG-SLA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90553_90553_1_TG-SLA_TG_chr8_133913798_ENST00000220616_SLA_chr8_134050982_ENST00000395352_length(transcript)=4759nt_BP=3674nt
CAGTGGTTTCTCCTCCTTCCTCCCAGGAAGGGCCAGGAAAATGGCCCTGGTCCTGGAGATCTTCACCCTGCTGGCCTCCATCTGCTGGGT
GTCGGCCAATATCTTCGAGTACCAGGTGGATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACGGCCTTTCTGAAGCAAGCAGA
CTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACTGTCCAGTGCCAGAACGACGGCCGCTCCTGCTGGTGTGTGGGTGCCAACGG
CAGTGAAGTGCTGGGCAGCAGGCAGCCAGGACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAACAGCAGATCTTACTGAGTGG
CTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGTCAGGATTCAGGGGACTACGCGCCTGTTCAGTGTGATGTGCAGCAGGTCCA
GTGCTGGTGTGTGGACGCAGAGGGGATGGAGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGTCCAAGGAGCTGTGAAATAAG
AAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCACCCCAGTGTTCTGCGGAGGGAGAGTTTATGCCTGTCCAGTGCAAATTTGT
CAACACCACAGACATGATGATTTTTGATCTGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACCTTCAGTTCCTTCCAGAGGAG
GTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGCCAAGGGCGGGAACTGGCTGAGACAGGTTTGGAGTTGTTACTGGATGAAAT
TTATGACACCATTTTTGCTGGCCTGGACCTTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTGCAGAGACGGTTCCTCGCAGT
TCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAATGTGAAGTGGAGCGGTTTACAGCAACCAGCTTTGGTCACCCCTATGTTCC
AAGCTGCCGCCGAAATGGCGACTATCAGGCGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGACGCCCAGGGGAAGGAAATGCA
TGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAAGGCCAATCTTGTGCCTCCGAAAGGCAGCAGGCCTTGTCCAGACTCTACTT
TGGGACCTCAGGCTACTTCAGCCAGCACGACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGAGTAGCCAGATTTGCCACATC
CTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGGCTTCTCCGCCCAATGGTGGAGGGACAGAGCCAACAGTTTTCTGTCTCAGA
AAATCTTCTCAAAGAAGCCATCCGAGCAATTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTTACCACCAACCCAAAGAGACT
CCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTTGGCCAGTTTAACTTGTCTGGAGCCCTTGGCACAAGAGGCACATTTAACTT
CAGTCAATTTTTCCAGCAACTTGGTCTTGCAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAGCCACTCTCTGTGGGATTAGA
TTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAGGATGGTACTATGAATAAGCCAACTGTGGGCAGCTTTGGCTTTGAAATTAA
CCTACAAGAGAACCAAAATGCCCTCAAATTCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTCTTGCAACATGCTATCTCTGT
GCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAAACGGTACTCAGCTCCCAGACCTGTGAGCAGACACCTGAAAGGCTATTTGT
CCCATCATGCACGACAGAAGGAAGCTATGAGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAATTCCTGGGGCAAAGAGCTTCC
AGGCTCAAGAGTCAGAGGTGGACAGCCAAGGTGCCCCACAGACTGTGAAAAGCAAAGGGCTCGCATGCAAAGCCTCATGGGCAGCCAGCC
TGCTGGCTCCACCTTGTTTGTCCCTGCTTGTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAACTCAGAGTGCTACTGTGTTGA
TGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATAGGGAAGCCCAAGAAATGCCCCACGCCCTGTCAATTACAGTCTGAGCAAGC
TTTCCTCAGGACGGTGCAGGCCCTGCTCTCTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATCCCACAGTGCAGCACCGATGG
GCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAGGTCTTCGAGTTGTACCAACGATGGGAGGCTCAGAACAAGGGCCAGGATCT
GACGCCTGCCAAGCTGCTAGTGAAGATCATGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTTATTCAAAGTCTGTATGAGGC
TGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCTTCTCTGCAAGATGTCCCACTAGCAGCACTGGAAGGGAAACGGCCCCAGCC
CAGGGAGAATATCCTCCTGGAGCCCTACCTCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCGGGGTCCTACTCAGACTTCAG
CACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGTGTGGATGAGGCTGGCCAAGAACTGGAAGGAATGCGGTCTGAGCCAAGCAA
GCTCCCAACATGTCCTGGCTCCTGTGAGGAAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAAGAGATTGTTTCAGCTTCCAA
CAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCCAAGGGAATCCGGCTGAGGAATGAGGACCTCGGCCTTCCTCCGCTCTTCCC
GCCCCGGGAGGCTTTCGCGGAGCAGTTTCTGCGTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCTACCTTAAGCTTCTATCAGAG
ACGCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCCCTTCTGCGGTCGGGCCCCTACATGCCACAGTGTGATGCGTTTGGAAGTTG
GGAGCCTGTGCAGTGCCACGCTGGGACTGGGCACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCTGGCTCACTGACTGCCCGCTC
TCTGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCTCGAACCAGTGGGCTGCTTTCCAGTTGGAAACAGGCTAGATCCCAAGAAAA
CCCATCTCCAAAAGACCTGTTCGTCCCAGCCTGCCTAGAAACAGGAGAGTATGCCAGGCTGCAGGCATCGGGGGCTGGCACCTGGTGTGT
GGACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGCAGCAGTGCCCAGTGCCCAAGCCTCTGCAATGTGCTCAAGAGTGGAGTCCT
CTCCAGGAGAGTCAGCCCAGGCTATGTCCCAGCCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAATGTGACCAGGCCCAGGGCAG
CTGCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGGACGCGCGTGACCGGGGGCCAGCCCGCCTGTGAGAACTGCAGGAGGACCCC
GAGGGAACAGAGAACCCGCTTGGGGTAGACGAGTCCCTTTTCAGCTATGGCCTTCGAGAGAGCATTGCCTCTTACCTGTCCCTGACCAGT
GAGGACAACACCTCCTTTGATCGAAAGAAGAAAAGCATCTCCCTGATGTATGGTGGCAGCAAGAGAAAGAGCTCATTCTTCTCATCACCA
CCTTACTTTGAGGACTAGCCAAGAACAGACACAATGGTTCATGCCCAAAAGGAACAGAAGTTCCAACTATTGCCTGGGATCTTGCGAAAA
GCGAGGTTCCCTGATCCCTGGGAGCCTCACGTATTTTAGAAGCCAAGAGAAGCCACATGGAGACTCAAATTCGCATCTTCTCTATCCACA
TCATGACCAAAGGAACCCCTCCCTGGTGTCTGATCAGGGCTGTGGCATCACGAAACATTGGATCATGACATGTCGGGCGATGCTTGGAAG
AGCCCAGCATGTATGTATGCACACATTGTGTGTGTGGGAAGGACAAAGCCACTCTCACAAGAAAGGGCACCAGGACTGCTCTCCAAGGAA
CTGGACCTGTCCAGACAGTTACACTCCAAGGTCATTGGAGAGAACTTCTGTATGGGCAAGCCTGAGAGGGAGAGGAAACAAAAGCTGTGT
CCTGGCAGAAGGTCTGGGTTTGCAGATGGGTGCCCTGAATGGAACTACTTTAACTAATCCATAGGGACTTCTGGTATGCTTTCCTCTCTT
TTTAAAGGAACTTCGTGACACTAAACATTAGCCCAAAGGACTTCTTAGCCTTCAATTGGGAGATACCTTTGGTCTGCTCCTGCACCAAAG
CCATATGGGTGGAAGTCAGTTGGCCTCCCTGGTTCTGCAGAGGGCCAGAAGAATGAGAGAGAGGAAGACTGCTGGCAGGGAAATCGAGGA
GGCGAGACTAGAACTGCACCAGCTTCCCTGATGTCTGCAGCCATGGCTTTGCAGCGCAGACAGAGCTTCTCTGGGATGCTGGGATTCTTG

>90553_90553_1_TG-SLA_TG_chr8_133913798_ENST00000220616_SLA_chr8_134050982_ENST00000395352_length(amino acids)=1225AA_BP=
MALVLEIFTLLASICWVSANIFEYQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPV
ACLSFCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSCEIRNRRLLHGVGDKSP
PQCSAEGEFMPVQCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADSQGRELAETGLELLLDEIYDTIFAGLDLPST
FTETTLYRILQRRFLAVQSVISGRFRCPTKCEVERFTATSFGHPYVPSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHGTRQQGEPPSCAE
GQSCASERQQALSRLYFGTSGYFSQHDLFSSPEKRWASPRVARFATSCPPTIKELFVDSGLLRPMVEGQSQQFSVSENLLKEAIRAIFPS
RGLARLALQFTTNPKRLQQNLFGGKFLVNVGQFNLSGALGTRGTFNFSQFFQQLGLASFLNGGRQEDLAKPLSVGLDSNSSTGTPEAAKK
DGTMNKPTVGSFGFEINLQENQNALKFLASLLELPEFLLFLQHAISVPEDVARDLGDVMETVLSSQTCEQTPERLFVPSCTTEGSYEDVQ
CFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAI
GKPKKCPTPCQLQSEQAFLRTVQALLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNGPPEQVFELYQRWEAQNKGQDLTPAKLLVKIMSYR
EAASGNFSLFIQSLYEAGQQDVFPVLSQYPSLQDVPLAALEGKRPQPRENILLEPYLFWQILNGQLSQYPGSYSDFSTPLAHFDLRNCWC
VDEAGQELEGMRSEPSKLPTCPGSCEEAKLRVLQFIRETEEIVSASNSSRFPLGESFLVAKGIRLRNEDLGLPPLFPPREAFAEQFLRGS
DYAIRLAAQSTLSFYQRRRFSPDDSAGASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKS
RTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSSSSAQCPSLCNVLKSGVLSRRVSPGYVPACR

--------------------------------------------------------------
>90553_90553_2_TG-SLA_TG_chr8_133913798_ENST00000220616_SLA_chr8_134050982_ENST00000517648_length(transcript)=3985nt_BP=3674nt
CAGTGGTTTCTCCTCCTTCCTCCCAGGAAGGGCCAGGAAAATGGCCCTGGTCCTGGAGATCTTCACCCTGCTGGCCTCCATCTGCTGGGT
GTCGGCCAATATCTTCGAGTACCAGGTGGATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACGGCCTTTCTGAAGCAAGCAGA
CTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACTGTCCAGTGCCAGAACGACGGCCGCTCCTGCTGGTGTGTGGGTGCCAACGG
CAGTGAAGTGCTGGGCAGCAGGCAGCCAGGACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAACAGCAGATCTTACTGAGTGG
CTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGTCAGGATTCAGGGGACTACGCGCCTGTTCAGTGTGATGTGCAGCAGGTCCA
GTGCTGGTGTGTGGACGCAGAGGGGATGGAGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGTCCAAGGAGCTGTGAAATAAG
AAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCACCCCAGTGTTCTGCGGAGGGAGAGTTTATGCCTGTCCAGTGCAAATTTGT
CAACACCACAGACATGATGATTTTTGATCTGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACCTTCAGTTCCTTCCAGAGGAG
GTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGCCAAGGGCGGGAACTGGCTGAGACAGGTTTGGAGTTGTTACTGGATGAAAT
TTATGACACCATTTTTGCTGGCCTGGACCTTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTGCAGAGACGGTTCCTCGCAGT
TCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAATGTGAAGTGGAGCGGTTTACAGCAACCAGCTTTGGTCACCCCTATGTTCC
AAGCTGCCGCCGAAATGGCGACTATCAGGCGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGACGCCCAGGGGAAGGAAATGCA
TGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAAGGCCAATCTTGTGCCTCCGAAAGGCAGCAGGCCTTGTCCAGACTCTACTT
TGGGACCTCAGGCTACTTCAGCCAGCACGACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGAGTAGCCAGATTTGCCACATC
CTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGGCTTCTCCGCCCAATGGTGGAGGGACAGAGCCAACAGTTTTCTGTCTCAGA
AAATCTTCTCAAAGAAGCCATCCGAGCAATTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTTACCACCAACCCAAAGAGACT
CCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTTGGCCAGTTTAACTTGTCTGGAGCCCTTGGCACAAGAGGCACATTTAACTT
CAGTCAATTTTTCCAGCAACTTGGTCTTGCAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAGCCACTCTCTGTGGGATTAGA
TTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAGGATGGTACTATGAATAAGCCAACTGTGGGCAGCTTTGGCTTTGAAATTAA
CCTACAAGAGAACCAAAATGCCCTCAAATTCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTCTTGCAACATGCTATCTCTGT
GCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAAACGGTACTCAGCTCCCAGACCTGTGAGCAGACACCTGAAAGGCTATTTGT
CCCATCATGCACGACAGAAGGAAGCTATGAGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAATTCCTGGGGCAAAGAGCTTCC
AGGCTCAAGAGTCAGAGGTGGACAGCCAAGGTGCCCCACAGACTGTGAAAAGCAAAGGGCTCGCATGCAAAGCCTCATGGGCAGCCAGCC
TGCTGGCTCCACCTTGTTTGTCCCTGCTTGTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAACTCAGAGTGCTACTGTGTTGA
TGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATAGGGAAGCCCAAGAAATGCCCCACGCCCTGTCAATTACAGTCTGAGCAAGC
TTTCCTCAGGACGGTGCAGGCCCTGCTCTCTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATCCCACAGTGCAGCACCGATGG
GCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAGGTCTTCGAGTTGTACCAACGATGGGAGGCTCAGAACAAGGGCCAGGATCT
GACGCCTGCCAAGCTGCTAGTGAAGATCATGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTTATTCAAAGTCTGTATGAGGC
TGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCTTCTCTGCAAGATGTCCCACTAGCAGCACTGGAAGGGAAACGGCCCCAGCC
CAGGGAGAATATCCTCCTGGAGCCCTACCTCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCGGGGTCCTACTCAGACTTCAG
CACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGTGTGGATGAGGCTGGCCAAGAACTGGAAGGAATGCGGTCTGAGCCAAGCAA
GCTCCCAACATGTCCTGGCTCCTGTGAGGAAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAAGAGATTGTTTCAGCTTCCAA
CAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCCAAGGGAATCCGGCTGAGGAATGAGGACCTCGGCCTTCCTCCGCTCTTCCC
GCCCCGGGAGGCTTTCGCGGAGCAGTTTCTGCGTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCTACCTTAAGCTTCTATCAGAG
ACGCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCCCTTCTGCGGTCGGGCCCCTACATGCCACAGTGTGATGCGTTTGGAAGTTG
GGAGCCTGTGCAGTGCCACGCTGGGACTGGGCACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCTGGCTCACTGACTGCCCGCTC
TCTGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCTCGAACCAGTGGGCTGCTTTCCAGTTGGAAACAGGCTAGATCCCAAGAAAA
CCCATCTCCAAAAGACCTGTTCGTCCCAGCCTGCCTAGAAACAGGAGAGTATGCCAGGCTGCAGGCATCGGGGGCTGGCACCTGGTGTGT
GGACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGCAGCAGTGCCCAGTGCCCAAGCCTCTGCAATGTGCTCAAGAGTGGAGTCCT
CTCCAGGAGAGTCAGCCCAGGCTATGTCCCAGCCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAATGTGACCAGGCCCAGGGCAG
CTGCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGGACGCGCGTGACCGGGGGCCAGCCCGCCTGTGAGAACTGCAGGAGGACCCC
GAGGGAACAGAGAACCCGCTTGGGGTAGACGAGTCCCTTTTCAGCTATGGCCTTCGAGAGAGCATTGCCTCTTACCTGTCCCTGACCAGT
GAGGACAACACCTCCTTTGATCGAAAGAAGAAAAGCATCTCCCTGATGTATGGTGGCAGCAAGAGAAAGAGCTCATTCTTCTCATCACCA
CCTTACTTTGAGGACTAGCCAAGAACAGACACAATGGTTCATGCCCAAAAGGAACAGAAGTTCCAACTATTGCCTGGGATCTTGCGAAAA

>90553_90553_2_TG-SLA_TG_chr8_133913798_ENST00000220616_SLA_chr8_134050982_ENST00000517648_length(amino acids)=1225AA_BP=
MALVLEIFTLLASICWVSANIFEYQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPV
ACLSFCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSCEIRNRRLLHGVGDKSP
PQCSAEGEFMPVQCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADSQGRELAETGLELLLDEIYDTIFAGLDLPST
FTETTLYRILQRRFLAVQSVISGRFRCPTKCEVERFTATSFGHPYVPSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHGTRQQGEPPSCAE
GQSCASERQQALSRLYFGTSGYFSQHDLFSSPEKRWASPRVARFATSCPPTIKELFVDSGLLRPMVEGQSQQFSVSENLLKEAIRAIFPS
RGLARLALQFTTNPKRLQQNLFGGKFLVNVGQFNLSGALGTRGTFNFSQFFQQLGLASFLNGGRQEDLAKPLSVGLDSNSSTGTPEAAKK
DGTMNKPTVGSFGFEINLQENQNALKFLASLLELPEFLLFLQHAISVPEDVARDLGDVMETVLSSQTCEQTPERLFVPSCTTEGSYEDVQ
CFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAI
GKPKKCPTPCQLQSEQAFLRTVQALLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNGPPEQVFELYQRWEAQNKGQDLTPAKLLVKIMSYR
EAASGNFSLFIQSLYEAGQQDVFPVLSQYPSLQDVPLAALEGKRPQPRENILLEPYLFWQILNGQLSQYPGSYSDFSTPLAHFDLRNCWC
VDEAGQELEGMRSEPSKLPTCPGSCEEAKLRVLQFIRETEEIVSASNSSRFPLGESFLVAKGIRLRNEDLGLPPLFPPREAFAEQFLRGS
DYAIRLAAQSTLSFYQRRRFSPDDSAGASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKS
RTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSSSSAQCPSLCNVLKSGVLSRRVSPGYVPACR

--------------------------------------------------------------
>90553_90553_3_TG-SLA_TG_chr8_133913798_ENST00000377869_SLA_chr8_134050982_ENST00000395352_length(transcript)=4760nt_BP=3675nt
GCAGTGGTTTCTCCTCCTTCCTCCCAGGAAGGGCCAGGAAAATGGCCCTGGTCCTGGAGATCTTCACCCTGCTGGCCTCCATCTGCTGGG
TGTCGGCCAATATCTTCGAGTACCAGGTGGATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACGGCCTTTCTGAAGCAAGCAG
ACTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACTGTCCAGTGCCAGAACGACGGCCGCTCCTGCTGGTGTGTGGGTGCCAACG
GCAGTGAAGTGCTGGGCAGCAGGCAGCCAGGACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAACAGCAGATCTTACTGAGTG
GCTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGTCAGGATTCAGGGGACTACGCGCCTGTTCAGTGTGATGTGCAGCAGGTCC
AGTGCTGGTGTGTGGACGCAGAGGGGATGGAGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGTCCAAGGAGCTGTGAAATAA
GAAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCACCCCAGTGTTCTGCGGAGGGAGAGTTTATGCCTGTCCAGTGCAAATTTG
TCAACACCACAGACATGATGATTTTTGATCTGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACCTTCAGTTCCTTCCAGAGGA
GGTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGCCAAGGGCGGGAACTGGCTGAGACAGGTTTGGAGTTGTTACTGGATGAAA
TTTATGACACCATTTTTGCTGGCCTGGACCTTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTGCAGAGACGGTTCCTCGCAG
TTCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAATGTGAAGTGGAGCGGTTTACAGCAACCAGCTTTGGTCACCCCTATGTTC
CAAGCTGCCGCCGAAATGGCGACTATCAGGCGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGACGCCCAGGGGAAGGAAATGC
ATGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAAGGCCAATCTTGTGCCTCCGAAAGGCAGCAGGCCTTGTCCAGACTCTACT
TTGGGACCTCAGGCTACTTCAGCCAGCACGACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGAGTAGCCAGATTTGCCACAT
CCTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGGCTTCTCCGCCCAATGGTGGAGGGACAGAGCCAACAGTTTTCTGTCTCAG
AAAATCTTCTCAAAGAAGCCATCCGAGCAATTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTTACCACCAACCCAAAGAGAC
TCCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTTGGCCAGTTTAACTTGTCTGGAGCCCTTGGCACAAGAGGCACATTTAACT
TCAGTCAATTTTTCCAGCAACTTGGTCTTGCAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAGCCACTCTCTGTGGGATTAG
ATTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAGGATGGTACTATGAATAAGCCAACTGTGGGCAGCTTTGGCTTTGAAATTA
ACCTACAAGAGAACCAAAATGCCCTCAAATTCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTCTTGCAACATGCTATCTCTG
TGCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAAACGGTACTCAGCTCCCAGACCTGTGAGCAGACACCTGAAAGGCTATTTG
TCCCATCATGCACGACAGAAGGAAGCTATGAGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAATTCCTGGGGCAAAGAGCTTC
CAGGCTCAAGAGTCAGAGGTGGACAGCCAAGGTGCCCCACAGACTGTGAAAAGCAAAGGGCTCGCATGCAAAGCCTCATGGGCAGCCAGC
CTGCTGGCTCCACCTTGTTTGTCCCTGCTTGTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAACTCAGAGTGCTACTGTGTTG
ATGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATAGGGAAGCCCAAGAAATGCCCCACGCCCTGTCAATTACAGTCTGAGCAAG
CTTTCCTCAGGACGGTGCAGGCCCTGCTCTCTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATCCCACAGTGCAGCACCGATG
GGCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAGGTCTTCGAGTTGTACCAACGATGGGAGGCTCAGAACAAGGGCCAGGATC
TGACGCCTGCCAAGCTGCTAGTGAAGATCATGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTTATTCAAAGTCTGTATGAGG
CTGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCTTCTCTGCAAGATGTCCCACTAGCAGCACTGGAAGGGAAACGGCCCCAGC
CCAGGGAGAATATCCTCCTGGAGCCCTACCTCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCGGGGTCCTACTCAGACTTCA
GCACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGTGTGGATGAGGCTGGCCAAGAACTGGAAGGAATGCGGTCTGAGCCAAGCA
AGCTCCCAACATGTCCTGGCTCCTGTGAGGAAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAAGAGATTGTTTCAGCTTCCA
ACAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCCAAGGGAATCCGGCTGAGGAATGAGGACCTCGGCCTTCCTCCGCTCTTCC
CGCCCCGGGAGGCTTTCGCGGAGCAGTTTCTGCGTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCTACCTTAAGCTTCTATCAGA
GACGCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCCCTTCTGCGGTCGGGCCCCTACATGCCACAGTGTGATGCGTTTGGAAGTT
GGGAGCCTGTGCAGTGCCACGCTGGGACTGGGCACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCTGGCTCACTGACTGCCCGCT
CTCTGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCTCGAACCAGTGGGCTGCTTTCCAGTTGGAAACAGGCTAGATCCCAAGAAA
ACCCATCTCCAAAAGACCTGTTCGTCCCAGCCTGCCTAGAAACAGGAGAGTATGCCAGGCTGCAGGCATCGGGGGCTGGCACCTGGTGTG
TGGACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGCAGCAGTGCCCAGTGCCCAAGCCTCTGCAATGTGCTCAAGAGTGGAGTCC
TCTCCAGGAGAGTCAGCCCAGGCTATGTCCCAGCCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAATGTGACCAGGCCCAGGGCA
GCTGCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGGACGCGCGTGACCGGGGGCCAGCCCGCCTGTGAGAACTGCAGGAGGACCC
CGAGGGAACAGAGAACCCGCTTGGGGTAGACGAGTCCCTTTTCAGCTATGGCCTTCGAGAGAGCATTGCCTCTTACCTGTCCCTGACCAG
TGAGGACAACACCTCCTTTGATCGAAAGAAGAAAAGCATCTCCCTGATGTATGGTGGCAGCAAGAGAAAGAGCTCATTCTTCTCATCACC
ACCTTACTTTGAGGACTAGCCAAGAACAGACACAATGGTTCATGCCCAAAAGGAACAGAAGTTCCAACTATTGCCTGGGATCTTGCGAAA
AGCGAGGTTCCCTGATCCCTGGGAGCCTCACGTATTTTAGAAGCCAAGAGAAGCCACATGGAGACTCAAATTCGCATCTTCTCTATCCAC
ATCATGACCAAAGGAACCCCTCCCTGGTGTCTGATCAGGGCTGTGGCATCACGAAACATTGGATCATGACATGTCGGGCGATGCTTGGAA
GAGCCCAGCATGTATGTATGCACACATTGTGTGTGTGGGAAGGACAAAGCCACTCTCACAAGAAAGGGCACCAGGACTGCTCTCCAAGGA
ACTGGACCTGTCCAGACAGTTACACTCCAAGGTCATTGGAGAGAACTTCTGTATGGGCAAGCCTGAGAGGGAGAGGAAACAAAAGCTGTG
TCCTGGCAGAAGGTCTGGGTTTGCAGATGGGTGCCCTGAATGGAACTACTTTAACTAATCCATAGGGACTTCTGGTATGCTTTCCTCTCT
TTTTAAAGGAACTTCGTGACACTAAACATTAGCCCAAAGGACTTCTTAGCCTTCAATTGGGAGATACCTTTGGTCTGCTCCTGCACCAAA
GCCATATGGGTGGAAGTCAGTTGGCCTCCCTGGTTCTGCAGAGGGCCAGAAGAATGAGAGAGAGGAAGACTGCTGGCAGGGAAATCGAGG
AGGCGAGACTAGAACTGCACCAGCTTCCCTGATGTCTGCAGCCATGGCTTTGCAGCGCAGACAGAGCTTCTCTGGGATGCTGGGATTCTT

>90553_90553_3_TG-SLA_TG_chr8_133913798_ENST00000377869_SLA_chr8_134050982_ENST00000395352_length(amino acids)=1225AA_BP=
MALVLEIFTLLASICWVSANIFEYQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPV
ACLSFCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSCEIRNRRLLHGVGDKSP
PQCSAEGEFMPVQCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADSQGRELAETGLELLLDEIYDTIFAGLDLPST
FTETTLYRILQRRFLAVQSVISGRFRCPTKCEVERFTATSFGHPYVPSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHGTRQQGEPPSCAE
GQSCASERQQALSRLYFGTSGYFSQHDLFSSPEKRWASPRVARFATSCPPTIKELFVDSGLLRPMVEGQSQQFSVSENLLKEAIRAIFPS
RGLARLALQFTTNPKRLQQNLFGGKFLVNVGQFNLSGALGTRGTFNFSQFFQQLGLASFLNGGRQEDLAKPLSVGLDSNSSTGTPEAAKK
DGTMNKPTVGSFGFEINLQENQNALKFLASLLELPEFLLFLQHAISVPEDVARDLGDVMETVLSSQTCEQTPERLFVPSCTTEGSYEDVQ
CFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAI
GKPKKCPTPCQLQSEQAFLRTVQALLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNGPPEQVFELYQRWEAQNKGQDLTPAKLLVKIMSYR
EAASGNFSLFIQSLYEAGQQDVFPVLSQYPSLQDVPLAALEGKRPQPRENILLEPYLFWQILNGQLSQYPGSYSDFSTPLAHFDLRNCWC
VDEAGQELEGMRSEPSKLPTCPGSCEEAKLRVLQFIRETEEIVSASNSSRFPLGESFLVAKGIRLRNEDLGLPPLFPPREAFAEQFLRGS
DYAIRLAAQSTLSFYQRRRFSPDDSAGASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKS
RTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSSSSAQCPSLCNVLKSGVLSRRVSPGYVPACR

--------------------------------------------------------------
>90553_90553_4_TG-SLA_TG_chr8_133913798_ENST00000377869_SLA_chr8_134050982_ENST00000517648_length(transcript)=3986nt_BP=3675nt
GCAGTGGTTTCTCCTCCTTCCTCCCAGGAAGGGCCAGGAAAATGGCCCTGGTCCTGGAGATCTTCACCCTGCTGGCCTCCATCTGCTGGG
TGTCGGCCAATATCTTCGAGTACCAGGTGGATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACGGCCTTTCTGAAGCAAGCAG
ACTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACTGTCCAGTGCCAGAACGACGGCCGCTCCTGCTGGTGTGTGGGTGCCAACG
GCAGTGAAGTGCTGGGCAGCAGGCAGCCAGGACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAACAGCAGATCTTACTGAGTG
GCTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGTCAGGATTCAGGGGACTACGCGCCTGTTCAGTGTGATGTGCAGCAGGTCC
AGTGCTGGTGTGTGGACGCAGAGGGGATGGAGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGTCCAAGGAGCTGTGAAATAA
GAAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCACCCCAGTGTTCTGCGGAGGGAGAGTTTATGCCTGTCCAGTGCAAATTTG
TCAACACCACAGACATGATGATTTTTGATCTGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACCTTCAGTTCCTTCCAGAGGA
GGTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGCCAAGGGCGGGAACTGGCTGAGACAGGTTTGGAGTTGTTACTGGATGAAA
TTTATGACACCATTTTTGCTGGCCTGGACCTTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTGCAGAGACGGTTCCTCGCAG
TTCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAATGTGAAGTGGAGCGGTTTACAGCAACCAGCTTTGGTCACCCCTATGTTC
CAAGCTGCCGCCGAAATGGCGACTATCAGGCGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGACGCCCAGGGGAAGGAAATGC
ATGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAAGGCCAATCTTGTGCCTCCGAAAGGCAGCAGGCCTTGTCCAGACTCTACT
TTGGGACCTCAGGCTACTTCAGCCAGCACGACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGAGTAGCCAGATTTGCCACAT
CCTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGGCTTCTCCGCCCAATGGTGGAGGGACAGAGCCAACAGTTTTCTGTCTCAG
AAAATCTTCTCAAAGAAGCCATCCGAGCAATTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTTACCACCAACCCAAAGAGAC
TCCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTTGGCCAGTTTAACTTGTCTGGAGCCCTTGGCACAAGAGGCACATTTAACT
TCAGTCAATTTTTCCAGCAACTTGGTCTTGCAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAGCCACTCTCTGTGGGATTAG
ATTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAGGATGGTACTATGAATAAGCCAACTGTGGGCAGCTTTGGCTTTGAAATTA
ACCTACAAGAGAACCAAAATGCCCTCAAATTCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTCTTGCAACATGCTATCTCTG
TGCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAAACGGTACTCAGCTCCCAGACCTGTGAGCAGACACCTGAAAGGCTATTTG
TCCCATCATGCACGACAGAAGGAAGCTATGAGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAATTCCTGGGGCAAAGAGCTTC
CAGGCTCAAGAGTCAGAGGTGGACAGCCAAGGTGCCCCACAGACTGTGAAAAGCAAAGGGCTCGCATGCAAAGCCTCATGGGCAGCCAGC
CTGCTGGCTCCACCTTGTTTGTCCCTGCTTGTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAACTCAGAGTGCTACTGTGTTG
ATGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATAGGGAAGCCCAAGAAATGCCCCACGCCCTGTCAATTACAGTCTGAGCAAG
CTTTCCTCAGGACGGTGCAGGCCCTGCTCTCTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATCCCACAGTGCAGCACCGATG
GGCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAGGTCTTCGAGTTGTACCAACGATGGGAGGCTCAGAACAAGGGCCAGGATC
TGACGCCTGCCAAGCTGCTAGTGAAGATCATGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTTATTCAAAGTCTGTATGAGG
CTGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCTTCTCTGCAAGATGTCCCACTAGCAGCACTGGAAGGGAAACGGCCCCAGC
CCAGGGAGAATATCCTCCTGGAGCCCTACCTCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCGGGGTCCTACTCAGACTTCA
GCACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGTGTGGATGAGGCTGGCCAAGAACTGGAAGGAATGCGGTCTGAGCCAAGCA
AGCTCCCAACATGTCCTGGCTCCTGTGAGGAAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAAGAGATTGTTTCAGCTTCCA
ACAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCCAAGGGAATCCGGCTGAGGAATGAGGACCTCGGCCTTCCTCCGCTCTTCC
CGCCCCGGGAGGCTTTCGCGGAGCAGTTTCTGCGTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCTACCTTAAGCTTCTATCAGA
GACGCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCCCTTCTGCGGTCGGGCCCCTACATGCCACAGTGTGATGCGTTTGGAAGTT
GGGAGCCTGTGCAGTGCCACGCTGGGACTGGGCACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCTGGCTCACTGACTGCCCGCT
CTCTGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCTCGAACCAGTGGGCTGCTTTCCAGTTGGAAACAGGCTAGATCCCAAGAAA
ACCCATCTCCAAAAGACCTGTTCGTCCCAGCCTGCCTAGAAACAGGAGAGTATGCCAGGCTGCAGGCATCGGGGGCTGGCACCTGGTGTG
TGGACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGCAGCAGTGCCCAGTGCCCAAGCCTCTGCAATGTGCTCAAGAGTGGAGTCC
TCTCCAGGAGAGTCAGCCCAGGCTATGTCCCAGCCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAATGTGACCAGGCCCAGGGCA
GCTGCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGGACGCGCGTGACCGGGGGCCAGCCCGCCTGTGAGAACTGCAGGAGGACCC
CGAGGGAACAGAGAACCCGCTTGGGGTAGACGAGTCCCTTTTCAGCTATGGCCTTCGAGAGAGCATTGCCTCTTACCTGTCCCTGACCAG
TGAGGACAACACCTCCTTTGATCGAAAGAAGAAAAGCATCTCCCTGATGTATGGTGGCAGCAAGAGAAAGAGCTCATTCTTCTCATCACC
ACCTTACTTTGAGGACTAGCCAAGAACAGACACAATGGTTCATGCCCAAAAGGAACAGAAGTTCCAACTATTGCCTGGGATCTTGCGAAA

>90553_90553_4_TG-SLA_TG_chr8_133913798_ENST00000377869_SLA_chr8_134050982_ENST00000517648_length(amino acids)=1225AA_BP=
MALVLEIFTLLASICWVSANIFEYQVDAQPLRPCELQRETAFLKQADYVPQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLGSRQPGRPV
ACLSFCQLQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSCEIRNRRLLHGVGDKSP
PQCSAEGEFMPVQCKFVNTTDMMIFDLVHSYNRFPDAFVTFSSFQRRFPEVSGYCHCADSQGRELAETGLELLLDEIYDTIFAGLDLPST
FTETTLYRILQRRFLAVQSVISGRFRCPTKCEVERFTATSFGHPYVPSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHGTRQQGEPPSCAE
GQSCASERQQALSRLYFGTSGYFSQHDLFSSPEKRWASPRVARFATSCPPTIKELFVDSGLLRPMVEGQSQQFSVSENLLKEAIRAIFPS
RGLARLALQFTTNPKRLQQNLFGGKFLVNVGQFNLSGALGTRGTFNFSQFFQQLGLASFLNGGRQEDLAKPLSVGLDSNSSTGTPEAAKK
DGTMNKPTVGSFGFEINLQENQNALKFLASLLELPEFLLFLQHAISVPEDVARDLGDVMETVLSSQTCEQTPERLFVPSCTTEGSYEDVQ
CFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAI
GKPKKCPTPCQLQSEQAFLRTVQALLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNGPPEQVFELYQRWEAQNKGQDLTPAKLLVKIMSYR
EAASGNFSLFIQSLYEAGQQDVFPVLSQYPSLQDVPLAALEGKRPQPRENILLEPYLFWQILNGQLSQYPGSYSDFSTPLAHFDLRNCWC
VDEAGQELEGMRSEPSKLPTCPGSCEEAKLRVLQFIRETEEIVSASNSSRFPLGESFLVAKGIRLRNEDLGLPPLFPPREAFAEQFLRGS
DYAIRLAAQSTLSFYQRRRFSPDDSAGASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKS
RTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEELRPGSSSSAQCPSLCNVLKSGVLSRRVSPGYVPACR

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Fusion Gene PPI Analysis for TG-SLA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TG-SLA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TG-SLA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource