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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THADA-NBAS (FusionGDB2 ID:90571)

Fusion Gene Summary for THADA-NBAS

check button Fusion gene summary
Fusion gene informationFusion gene name: THADA-NBAS
Fusion gene ID: 90571
HgeneTgene
Gene symbol

THADA

NBAS

Gene ID

63892

51594

Gene nameTHADA armadillo repeat containingNBAS subunit of NRZ tethering complex
SynonymsARMC13|GITAILFS2|NAG|SOPH
Cytomap

2p21

2p24.3

Type of geneprotein-codingprotein-coding
Descriptionthyroid adenoma-associated proteindeath receptor-interacting proteingene inducing thyroid adenomas proteinneuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma amplified sequenceneuroblastoma-amplified gene protein
Modification date2020031320200313
UniProtAcc.

A2RRP1

Ensembl transtripts involved in fusion geneENST00000405006, ENST00000405975, 
ENST00000330266, ENST00000402360, 
ENST00000403856, ENST00000404790, 
ENST00000415080, ENST00000485353, 
ENST00000281513, ENST00000441750, 
Fusion gene scores* DoF score16 X 16 X 12=307215 X 15 X 6=1350
# samples 1815
** MAII scorelog2(18/3072*10)=-4.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1350*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THADA [Title/Abstract] AND NBAS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNBAS(15467874)-THADA(43819555), # samples:1
THADA(43712372)-NBAS(15523441), # samples:1
Anticipated loss of major functional domain due to fusion event.THADA-NBAS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across THADA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NBAS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4H2THADAchr2

43712372

-NBASchr2

15523441

-


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Fusion Gene ORF analysis for THADA-NBAS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000405006ENST00000281513THADAchr2

43712372

-NBASchr2

15523441

-
Frame-shiftENST00000405006ENST00000441750THADAchr2

43712372

-NBASchr2

15523441

-
Frame-shiftENST00000405975ENST00000281513THADAchr2

43712372

-NBASchr2

15523441

-
Frame-shiftENST00000405975ENST00000441750THADAchr2

43712372

-NBASchr2

15523441

-
In-frameENST00000330266ENST00000281513THADAchr2

43712372

-NBASchr2

15523441

-
In-frameENST00000330266ENST00000441750THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000402360ENST00000281513THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000402360ENST00000441750THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000403856ENST00000281513THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000403856ENST00000441750THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000404790ENST00000281513THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000404790ENST00000441750THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000415080ENST00000281513THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000415080ENST00000441750THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000485353ENST00000281513THADAchr2

43712372

-NBASchr2

15523441

-
intron-3CDSENST00000485353ENST00000441750THADAchr2

43712372

-NBASchr2

15523441

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000330266THADAchr243712372-ENST00000441750NBASchr215523441-69652966068242274
ENST00000330266THADAchr243712372-ENST00000281513NBASchr215523441-69642966068242274

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000330266ENST00000441750THADAchr243712372-NBASchr215523441-0.0010300810.9989699
ENST00000330266ENST00000281513THADAchr243712372-NBASchr215523441-0.0010266760.99897337

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Fusion Genomic Features for THADA-NBAS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THADA-NBAS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:15467874/chr2:43819555)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NBAS

A2RRP1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). {ECO:0000269|PubMed:19369418, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHADAchr2:43712372chr2:15523441ENST00000405006-2638886_91812781954.0Coiled coilOntology_term=ECO:0000255
HgeneTHADAchr2:43712372chr2:15523441ENST00000405975-2638886_91812781954.0Coiled coilOntology_term=ECO:0000255
HgeneTHADAchr2:43712372chr2:15523441ENST00000405006-26384_712781954.0Compositional biasNote=Poly-Lys
HgeneTHADAchr2:43712372chr2:15523441ENST00000405975-26384_712781954.0Compositional biasNote=Poly-Lys
TgeneNBASchr2:43712372chr2:15523441ENST0000028151327521421_142510852372.0Compositional biasNote=Poly-Thr
TgeneNBASchr2:43712372chr2:15523441ENST0000028151327522242_224710852372.0Compositional biasNote=Poly-Leu
TgeneNBASchr2:43712372chr2:15523441ENST0000044175025501421_14259652252.0Compositional biasNote=Poly-Thr
TgeneNBASchr2:43712372chr2:15523441ENST0000044175025502242_22479652252.0Compositional biasNote=Poly-Leu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHADAchr2:43712372chr2:15523441ENST00000402360-117886_9180938.0Coiled coilOntology_term=ECO:0000255
HgeneTHADAchr2:43712372chr2:15523441ENST00000402360-1171322_13270938.0Compositional biasNote=Poly-Leu
HgeneTHADAchr2:43712372chr2:15523441ENST00000402360-1171529_15320938.0Compositional biasNote=Poly-Ala
HgeneTHADAchr2:43712372chr2:15523441ENST00000402360-1174_70938.0Compositional biasNote=Poly-Lys
HgeneTHADAchr2:43712372chr2:15523441ENST00000405006-26381322_132712781954.0Compositional biasNote=Poly-Leu
HgeneTHADAchr2:43712372chr2:15523441ENST00000405006-26381529_153212781954.0Compositional biasNote=Poly-Ala
HgeneTHADAchr2:43712372chr2:15523441ENST00000405975-26381322_132712781954.0Compositional biasNote=Poly-Leu
HgeneTHADAchr2:43712372chr2:15523441ENST00000405975-26381529_153212781954.0Compositional biasNote=Poly-Ala
TgeneNBASchr2:43712372chr2:15523441ENST000002815132752130_16910852372.0RepeatNote=WD 1
TgeneNBASchr2:43712372chr2:15523441ENST000002815132752316_35510852372.0RepeatNote=WD 2
TgeneNBASchr2:43712372chr2:15523441ENST000004417502550130_1699652252.0RepeatNote=WD 1
TgeneNBASchr2:43712372chr2:15523441ENST000004417502550316_3559652252.0RepeatNote=WD 2


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Fusion Gene Sequence for THADA-NBAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90571_90571_1_THADA-NBAS_THADA_chr2_43712372_ENST00000330266_NBAS_chr2_15523441_ENST00000281513_length(transcript)=6964nt_BP=2966nt
ATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGACACTTGCCATGTTGGACTGG
CAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGAGTTCACAGATTAAAGAGCCA
ACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAAGTTCCCCGAGCCTAACGGAC
AGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCATTGGATGCTCTGAGACACCAA
ACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTGATCCTTTCTTTGTGGAATTG
ACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGTGCATAGGAGTTGAACATATT
TTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATGCAAGTGACCTCTTGGAAACC
ATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATGAGACTTGGGTTTCTCCTCTC
CTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTATTAAGTTACAGCCCTGAAAGC
TTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCATCCTTAGGGTCTTGTAATAGC
AGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAACTGATACCTGGGAGAACCTC
GTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCTTGCTTTGTGAAAGTAATCGG
AGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCCAGTCTCCAGGAGTGCGGCAA
CAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGGAGCAGAGTAAATCCAAACGT
GAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCATCCATTTGTAACAGTCTTTTT
GAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTGAAGTTTTTCATGTCCCAGAA
GGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAATGTTTTACCAGCACTTTTGAA
GACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGGGGAAACTGCAAGGCTTATTT
CAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACTTCTTAATCTGGCAGGATGCT
CTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTGTGGTGGAAAGGAACACATTA
ATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGGCAGCAGCAGCATTTCCAATG
TATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCGAGTGGAGACCTGTGGTAGAG
AAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAGGCCTCATCCCAATGGACACT
GATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATTTTAACCAAGCCAAAATATTG
AAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAATCAAAGGTAAAGAAGTAAAA
ACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTTTAGGCATGTTGTGCCAGCTT
CTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTT
TTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGT
CTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGC
AGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAG
TTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGAT
ACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGA
AATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGGCAG
CCTCCTGTCAGTGAGTCTCATTGGAGAACGTTGCTGCAAGACATGTTAACTATGCAGCAGAATGTATACACATGTCTAGATTCTGATGCC
TGCTATGAGATATTTACAGAAAGCCTTCTGTGCTCTAGTCGCCTTGAAAACATCCACCTGGCTGGACAGATGATGCACTGCAGTGCTTGT
TCAGAAAATCCTCCAGCTGGTATAGCCCATAAAGGGAAACCCCACTACAGGGTCAGCTACGAAAAGAGTATTGACTTGGTTTTGGCTGCC
AGCAGAGAGTACTTCAATTCTTCTACCAACCTCACTGATAGCTGCATGGATCTAGCCAGGTGCTGCTTACAACTGATAACAGACAGACCC
CCTGCCATTCAAGAGGAGCTAGATCTTATCCAAGCCGTTGGATGTCTTGAAGAATTTGGGGTAAAGATCCTGCCTTTGCAAGTGCGATTG
TGCCCTGATCGGATCAGTCTCATCAAGGAGTGTATTTCCCAGTCCCCCACATGCTATAAACAATCCACCAAGCTTCTGGGCCTTGCTGAG
CTGCTGAGGGTTGCAGGTGAGAACCCAGAAGAAAGGCGGGGACAGGTTCTAATCCTTTTAGTGGAGCAGGCACTTCGCTTCCATGACTAC
AAAGCAGCCAGTATGCATTGTCAGGAGCTGATGGCCACAGGTTATCCTAAAAGTTGGGATGTTTGTAGCCAGTTAGGACAATCAGAAGGT
TACCAGGACTTGGCCACTCGTCAAGAGCTCATGGCTTTTGCTTTGACACATTGCCCTCCTAGCAGCATTGAACTTCTTTTGGCAGCTAGC
AGCTCTCTGCAGACAGAAATTCTTTATCAAAGAGTGAATTTCCAGATCCATCATGAAGGAGGGGAAAATATCAGTGCTTCACCATTAACT
AGTAAAGCAGTACAAGAGGATGAAGTAGGTGTTCCAGGTAGCAATTCAGCTGACCTATTGCGCTGGACCACTGCTACCACCATGAAAGTC
CTTTCCAACACCACAACCACCACCAAAGCGGTGCTGCAGGCCGTCAGTGATGGGCAGTGGTGGAAGAAGTCTTTAACTTACCTTCGACCC
CTTCAGGGGCAAAAATGTGGTGGTGCATATCAAATCGGAACTACAGCCAATGAAGATCTAGAGAAACAAGGGTGTCATCCTTTTTATGAA
TCTGTCATCTCAAATCCTTTTGTCGCTGAGTCTGAAGGGACCTATGACACCTATCAGCATGTTCCAGTGGAAAGCTTTGCAGAAGTATTG
CTGAGAACTGGAAAATTGGCAGAGGCTAAAAATAAAGGAGAAGTATTTCCAACAACTGAAGTTCTCTTGCAACTAGCAAGTGAAGCCTTG
CCAAATGACATGACCTTGGCTCTTGCTTACCTTCTTGCCTTACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCT
GCATTATCTCTCCAGCTGGCAGCGTATTACTATAGCCTCCAGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTT
TACAGGGCTGATCCCAAAGAACTAATCAAGATGGTCACCAGGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCA
CTGACCAAGCAGTTACACTGCTACAATGAACGTCTCCTGGATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTG
CAGCGGTTTACTGCAGATGACCAGTATAAAAGGGAAACTATCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATT
TCTCTGGCACAACGTTACAGTGTCTCCCGCTGGGAAGTTTTTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTA
GAAATTGAAAATAGAGCCCAAGACCTTCATCTCTTTGAGACTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATT
TACCCTACTATTGGTGGCTTTGATCACGAAAGGCTGCAGTATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGT
GCCATTAAACCAGAAACCCACATTCGACTGCTGAAGAAGTTTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAAC
ATGAGTCCTCTTGAAGCATTGGAGCCAGTTCTTTCAAGTCAAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGAT
GGACAGATGCTTTCCCCAAGCTCTCTGTACACCATCTGGTTACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCA
GGCTCTTCACCGGAGTGGCTTCATGCCTATGATGTCTGCATGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGAT
GCAGTTACATTTTCTCCAAAAGCTGTGACCAAGCTGTCTGTGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGACAGTCAAACAT
TTTATTGAGAAGCCAAGGAAAAGAAACTCAGAAGACGAAGCTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATACTTTGAATCAT
CTGGAGAAATCACTTGCCCACCTGGAAACCCTGAGCCACAGCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACTGCAAAAATAC
AGTCACCTCTATGATCTGTCCCGATCAGAAAAAGAGAAACTTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCCTCTAGCAATG
ATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCCTCTTGACATCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAATAATTTCTGCA
TTGAGTGGTGGCAGTGCTGACCTTGGTGGGCCAAGGGACCCACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGCCAGTGTGGAC
AAGGGTGAGGAGCTGGTTTCACCTGAGGACCTGCTGGAGTGGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCGGCCCCGCATT
CACGTGCTGCAGATTTTGGGGCAATCATTTCACCTGACTGAGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGCCATTCTCAAA
GCCTCCTGGCCCCAGAGACAGGTAGACATAGCTGACATTGAGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCTGGAATCTAGT
CACCACGAGGCTGAATTTCAGCACTTGGTTTTACTTTTGCAAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAATAATCCATGG
GTGAGACTAGCTACAGTGATGCTAACCAGATGTACGATGGAGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTGTCGCTCTTTG
TATAACACCAAGCAGATGCTGCCTGCAGAGGGTGTGAAGGAGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCCATCTCTGAAA
CTTCTCCTCGAGAGCCGAGATGAGCATCTGCACGAGATGGCACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTCCAATTGTGAC
CAAGAACTTCTTTCCCTGCTCCTGGATGCCAAGCTGCTGGTGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGACCACCTCTTG
GCTAGCCTCCAGCAAGGGCGCTGGGATGCAGAGGAGCTGGGCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGGGTCTCTCCTT
CTGGCCGTGAGGGGGACTCACCAGGCCTTCAGAACCTTCAGTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCCACCTGTGGCC
CTGCTCCTTAGCAGAAAAAGCATCTGGAGTTGAATGCTGTTCCCAGAAGCAACATGTGTATCTGCCGATTGTTCTCCATGGTTCCAACAA

>90571_90571_1_THADA-NBAS_THADA_chr2_43712372_ENST00000330266_NBAS_chr2_15523441_ENST00000281513_length(amino acids)=2274AA_BP=988
MSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTD
SLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHI
LAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPES
LQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGLIHQHCQVRIDTLGLLCESNR
STEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLF
EALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLF
QAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAENSLLQAAAAFPM
YGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKIL
KEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHL
LQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKE
LISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRQ
PPVSESHWRTLLQDMLTMQQNVYTCLDSDACYEIFTESLLCSSRLENIHLAGQMMHCSACSENPPAGIAHKGKPHYRVSYEKSIDLVLAA
SREYFNSSTNLTDSCMDLARCCLQLITDRPPAIQEELDLIQAVGCLEEFGVKILPLQVRLCPDRISLIKECISQSPTCYKQSTKLLGLAE
LLRVAGENPEERRGQVLILLVEQALRFHDYKAASMHCQELMATGYPKSWDVCSQLGQSEGYQDLATRQELMAFALTHCPPSSIELLLAAS
SSLQTEILYQRVNFQIHHEGGENISASPLTSKAVQEDEVGVPGSNSADLLRWTTATTMKVLSNTTTTTKAVLQAVSDGQWWKKSLTYLRP
LQGQKCGGAYQIGTTANEDLEKQGCHPFYESVISNPFVAESEGTYDTYQHVPVESFAEVLLRTGKLAEAKNKGEVFPTTEVLLQLASEAL
PNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAPCFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLIS
LTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETLEESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTL
EIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLENCGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDEN
MSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTGDPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITVVD
AVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSKVTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQKY
SHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQSAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHASVD
KGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLVFFRTEAILKASWPQRQVDIADIENEENRYCLFMELLESS
HHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGNEVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPSLK
LLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPFYPRIVDHLLASLQQGRWDAEELGRHLREAGHEAEAGSLL

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>90571_90571_2_THADA-NBAS_THADA_chr2_43712372_ENST00000330266_NBAS_chr2_15523441_ENST00000441750_length(transcript)=6965nt_BP=2966nt
ATGAGCAGCTGCAGGAGCCTCTGTTGTGGTGACATCTCTCAGTCAGCTGTCTTATTCCTCTGTCAGGGGACACTTGCCATGTTGGACTGG
CAGAACGGAAGCATGGGTCGGAGTGGGGAGGCCCTGCTCTTGGATACTGCACATGTTTTGTTCACCTTGAGTTCACAGATTAAAGAGCCA
ACGCTGGAAATGTTTCTGTCTAGAATCTTAGCATCCTGGACTAATTCAGCCATACAAGTCCTTGAATCAAGTTCCCCGAGCCTAACGGAC
AGCCTGAATGGGAATTCAAGTATAGTTGGGAGACTTTTGGAATATGTCTATACCCATTGGGAACATCCATTGGATGCTCTGAGACACCAA
ACCAAAATCATGTTCAAAAACCTTCTCCAAATGCACCGGCTCACTGTGGAAGGTGCAGATTTCGTCCCTGATCCTTTCTTTGTGGAATTG
ACTGAGAGTCTTTTACGATTGGAATGGCATATTAAAGGAAAGTACACGTGCCTTGGTTGTTTGGTAGAGTGCATAGGAGTTGAACATATT
TTGGCTATAGATAAAACTATTCCATCTCAAATCTTAGAGGTGATGGGAGACCAGTCATTGGTACCTTATGCAAGTGACCTCTTGGAAACC
ATGTTTAGAAATCATAAGAGTCATTTGAAATCCCAGACTGCTGAGAGTTCTTGGATTGACCAGTGGCATGAGACTTGGGTTTCTCCTCTC
CTTTTTATATTGTGTGAAGGAAACTTGGATCAAAAATCTTACGTGATTGATTATTACTTGCCAAAATTATTAAGTTACAGCCCTGAAAGC
TTACAGTACATGGTAAAGATTCTTCAGACTTCTATTGATGCTAAAACTGGACAAGAGCAATCTTTCCCATCCTTAGGGTCTTGTAATAGC
AGGGGGGCTCTGGGAGCTTTGATGGCATGTCTGCGAATAGCTAGAGCTCATGGACATCTTCAGTCTGCAACTGATACCTGGGAGAACCTC
GTGTCTGATGCAAGAATAAAGCAAGGCTTAATTCATCAGCATTGCCAAGTAAGGATAGATACATTAGGCTTGCTTTGTGAAAGTAATCGG
AGCACAGAAATTGTTTCCATGGAAGAAATGCAGTGGATTCAGTTCTTTATTACATACAATCTTAACAGCCAGTCTCCAGGAGTGCGGCAA
CAGATCTGTTCTCTTCTTAAAAAGTTGTTTTGTAGGATACAGGAAAGTTCTCAGGTACTTTATAAATTGGAGCAGAGTAAATCCAAACGT
GAACCAGAGAATGAGTTAACCAAACAGCACCCTTCTGTTTCTTTACAGCAGTATAAGAATTTCATGTCATCCATTTGTAACAGTCTTTTT
GAAGCATTGTTTCCTGGATCTTCCTACTCGACTAGATTTTCAGCTTTAACCATTTTAGGTTCAATAGCTGAAGTTTTTCATGTCCCAGAA
GGCAGAATTTATACAGTATATCAGCTGAGTCATGATATTGATGTTGGTCGTTTCCAAACACTAATGGAATGTTTTACCAGCACTTTTGAA
GACGTGAAAATTTTAGCATTTGATCTTCTGATGAAGTTATCAAAAACAGCTGTACATTTTCAGGATTCGGGGAAACTGCAAGGCTTATTT
CAGGCAGCATTGGAGCTCAGCACAAGCACCAAACCATACGACTGTGTGACAGCTTCCTACCTGCTGAACTTCTTAATCTGGCAGGATGCT
CTACCGTCATCCTTGTCTGCCTACTTAACTCAGCAAGTTGCATGTGATAATGGAGATAGGCCTGCTGCTGTGGTGGAAAGGAACACATTA
ATGGTTATCAAATGCTTGATGGAAAATCTTGAGGAAGAAGTATCTCAGGCTGAAAATTCTCTGCTTCAGGCAGCAGCAGCATTTCCAATG
TATGGGCGAGTCCACTGTATAACAGGAGCTTTGCAGAAGTTATCTCTAAACAGCCTGCAGTTGGTGAGCGAGTGGAGACCTGTGGTAGAG
AAGCTCCTTTTGATGTCCTACAGGCTTTCCACTGTGGTGTCTCCAGTCATTCAGAGCTCATCCCCTGAAGGCCTCATCCCAATGGACACT
GATTCAGAGTCAGCAAGCCGCTTACAGATGATTCTGAATGAGATTCAGCCTCGAGATACTAATGATTATTTTAACCAAGCCAAAATATTG
AAAGAACATGATAGCTTTGATATGAAGGACTTGAATGCTAGTGTGGTGAATATTGATACTTCTACAGAAATCAAAGGTAAAGAAGTAAAA
ACATGTGATGTAACTGCGCAGATGGTGCTGGTATGTTGTTGGAGAAGTATGAAGGAAGTTGCTTTACTTTTAGGCATGTTGTGCCAGCTT
CTGCCCATGCAGCCTGTGCCAGAATCTTCTGATGGATTATTGACGGTGGAGCAGGTAAAAGAAATAGGAGATTACTTTAAACAACACCTT
TTGCAGTCCAGGCACAGAGGAGCATTTGAATTGGCTTATACTGGTTTTGTGAAACTCACTGAAGTACTAAACAGGTGCCCAAATGTGAGT
CTGCAAAAGCTGCCAGAACAGTGGCTATGGAGTGTTTTAGAGGAAATTAAATGCAGTGATCCTTCATCTAAACTCTGTGCTACAAGGCGC
AGTGCTGGAATTCCTTTCTACATACAGGCACTGTTGGCATCTGAACCAAAGAAAGGCAGAATGGATTTGTTGAAAATAACAATGAAAGAG
TTAATCTCTTTGGCTGGGCCTACAGATGACATACAGAGTACAGTCCCCCAGGTTCATGCTTTAAATATCCTTAGAGCATTGTTCAGAGAT
ACGCGCCTGGGAGAAAATATTATTCCTTATGTTGCTGATGGAGCTAAGGCTGCAATTCTGGGTTTTACATCACCGGTCTGGGCAGTGCGA
AATTCATCCACACTTCTCTTTAGTGCCTTGATCACAAGAATTTTTGGAGTTAAAAGGGCAAAGGATGAACATTCCAAAACAAATAGGCAG
CCTCCTGTCAGTGAGTCTCATTGGAGAACGTTGCTGCAAGACATGTTAACTATGCAGCAGAATGTATACACATGTCTAGATTCTGATGCC
TGCTATGAGATATTTACAGAAAGCCTTCTGTGCTCTAGTCGCCTTGAAAACATCCACCTGGCTGGACAGATGATGCACTGCAGTGCTTGT
TCAGAAAATCCTCCAGCTGGTATAGCCCATAAAGGGAAACCCCACTACAGGGTCAGCTACGAAAAGAGTATTGACTTGGTTTTGGCTGCC
AGCAGAGAGTACTTCAATTCTTCTACCAACCTCACTGATAGCTGCATGGATCTAGCCAGGTGCTGCTTACAACTGATAACAGACAGACCC
CCTGCCATTCAAGAGGAGCTAGATCTTATCCAAGCCGTTGGATGTCTTGAAGAATTTGGGGTAAAGATCCTGCCTTTGCAAGTGCGATTG
TGCCCTGATCGGATCAGTCTCATCAAGGAGTGTATTTCCCAGTCCCCCACATGCTATAAACAATCCACCAAGCTTCTGGGCCTTGCTGAG
CTGCTGAGGGTTGCAGGTGAGAACCCAGAAGAAAGGCGGGGACAGGTTCTAATCCTTTTAGTGGAGCAGGCACTTCGCTTCCATGACTAC
AAAGCAGCCAGTATGCATTGTCAGGAGCTGATGGCCACAGGTTATCCTAAAAGTTGGGATGTTTGTAGCCAGTTAGGACAATCAGAAGGT
TACCAGGACTTGGCCACTCGTCAAGAGCTCATGGCTTTTGCTTTGACACATTGCCCTCCTAGCAGCATTGAACTTCTTTTGGCAGCTAGC
AGCTCTCTGCAGACAGAAATTCTTTATCAAAGAGTGAATTTCCAGATCCATCATGAAGGAGGGGAAAATATCAGTGCTTCACCATTAACT
AGTAAAGCAGTACAAGAGGATGAAGTAGGTGTTCCAGGTAGCAATTCAGCTGACCTATTGCGCTGGACCACTGCTACCACCATGAAAGTC
CTTTCCAACACCACAACCACCACCAAAGCGGTGCTGCAGGCCGTCAGTGATGGGCAGTGGTGGAAGAAGTCTTTAACTTACCTTCGACCC
CTTCAGGGGCAAAAATGTGGTGGTGCATATCAAATCGGAACTACAGCCAATGAAGATCTAGAGAAACAAGGGTGTCATCCTTTTTATGAA
TCTGTCATCTCAAATCCTTTTGTCGCTGAGTCTGAAGGGACCTATGACACCTATCAGCATGTTCCAGTGGAAAGCTTTGCAGAAGTATTG
CTGAGAACTGGAAAATTGGCAGAGGCTAAAAATAAAGGAGAAGTATTTCCAACAACTGAAGTTCTCTTGCAACTAGCAAGTGAAGCCTTG
CCAAATGACATGACCTTGGCTCTTGCTTACCTTCTTGCCTTACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCT
GCATTATCTCTCCAGCTGGCAGCGTATTACTATAGCCTCCAGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTT
TACAGGGCTGATCCCAAAGAACTAATCAAGATGGTCACCAGGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCA
CTGACCAAGCAGTTACACTGCTACAATGAACGTCTCCTGGATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTG
CAGCGGTTTACTGCAGATGACCAGTATAAAAGGGAAACTATCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATT
TCTCTGGCACAACGTTACAGTGTCTCCCGCTGGGAAGTTTTTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTA
GAAATTGAAAATAGAGCCCAAGACCTTCATCTCTTTGAGACTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATT
TACCCTACTATTGGTGGCTTTGATCACGAAAGGCTGCAGTATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGT
GCCATTAAACCAGAAACCCACATTCGACTGCTGAAGAAGTTTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAAC
ATGAGTCCTCTTGAAGCATTGGAGCCAGTTCTTTCAAGTCAAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGAT
GGACAGATGCTTTCCCCAAGCTCTCTGTACACCATCTGGTTACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCA
GGCTCTTCACCGGAGTGGCTTCATGCCTATGATGTCTGCATGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGAT
GCAGTTACATTTTCTCCAAAAGCTGTGACCAAGCTGTCTGTGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGACAGTCAAACAT
TTTATTGAGAAGCCAAGGAAAAGAAACTCAGAAGACGAAGCTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATACTTTGAATCAT
CTGGAGAAATCACTTGCCCACCTGGAAACCCTGAGCCACAGCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACTGCAAAAATAC
AGTCACCTCTATGATCTGTCCCGATCAGAAAAAGAGAAACTTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCCTCTAGCAATG
ATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCCTCTTGACATCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAATAATTTCTGCA
TTGAGTGGTGGCAGTGCTGACCTTGGTGGGCCAAGGGACCCACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGCCAGTGTGGAC
AAGGGTGAGGAGCTGGTTTCACCTGAGGACCTGCTGGAGTGGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCGGCCCCGCATT
CACGTGCTGCAGATTTTGGGGCAATCATTTCACCTGACTGAGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGCCATTCTCAAA
GCCTCCTGGCCCCAGAGACAGGTAGACATAGCTGACATTGAGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCTGGAATCTAGT
CACCACGAGGCTGAATTTCAGCACTTGGTTTTACTTTTGCAAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAATAATCCATGG
GTGAGACTAGCTACAGTGATGCTAACCAGATGTACGATGGAGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTGTCGCTCTTTG
TATAACACCAAGCAGATGCTGCCTGCAGAGGGTGTGAAGGAGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCCATCTCTGAAA
CTTCTCCTCGAGAGCCGAGATGAGCATCTGCACGAGATGGCACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTCCAATTGTGAC
CAAGAACTTCTTTCCCTGCTCCTGGATGCCAAGCTGCTGGTGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGACCACCTCTTG
GCTAGCCTCCAGCAAGGGCGCTGGGATGCAGAGGAGCTGGGCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGGGTCTCTCCTT
CTGGCCGTGAGGGGGACTCACCAGGCCTTCAGAACCTTCAGTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCCACCTGTGGCC
CTGCTCCTTAGCAGAAAAAGCATCTGGAGTTGAATGCTGTTCCCAGAAGCAACATGTGTATCTGCCGATTGTTCTCCATGGTTCCAACAA

>90571_90571_2_THADA-NBAS_THADA_chr2_43712372_ENST00000330266_NBAS_chr2_15523441_ENST00000441750_length(amino acids)=2274AA_BP=988
MSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTD
SLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHI
LAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPES
LQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGLIHQHCQVRIDTLGLLCESNR
STEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLF
EALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLF
QAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAENSLLQAAAAFPM
YGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKIL
KEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHL
LQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKE
LISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRQ
PPVSESHWRTLLQDMLTMQQNVYTCLDSDACYEIFTESLLCSSRLENIHLAGQMMHCSACSENPPAGIAHKGKPHYRVSYEKSIDLVLAA
SREYFNSSTNLTDSCMDLARCCLQLITDRPPAIQEELDLIQAVGCLEEFGVKILPLQVRLCPDRISLIKECISQSPTCYKQSTKLLGLAE
LLRVAGENPEERRGQVLILLVEQALRFHDYKAASMHCQELMATGYPKSWDVCSQLGQSEGYQDLATRQELMAFALTHCPPSSIELLLAAS
SSLQTEILYQRVNFQIHHEGGENISASPLTSKAVQEDEVGVPGSNSADLLRWTTATTMKVLSNTTTTTKAVLQAVSDGQWWKKSLTYLRP
LQGQKCGGAYQIGTTANEDLEKQGCHPFYESVISNPFVAESEGTYDTYQHVPVESFAEVLLRTGKLAEAKNKGEVFPTTEVLLQLASEAL
PNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAPCFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLIS
LTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETLEESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTL
EIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLENCGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDEN
MSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTGDPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITVVD
AVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSKVTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQKY
SHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQSAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHASVD
KGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLVFFRTEAILKASWPQRQVDIADIENEENRYCLFMELLESS
HHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGNEVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPSLK
LLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPFYPRIVDHLLASLQQGRWDAEELGRHLREAGHEAEAGSLL

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Fusion Gene PPI Analysis for THADA-NBAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneNBASchr2:43712372chr2:15523441ENST0000044175025501036_2371965.66666666666662252.0ZW10 and RINT1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNBASchr2:43712372chr2:15523441ENST0000028151327521_10351085.66666666666672372.0USE1L
TgeneNBASchr2:43712372chr2:15523441ENST0000044175025501_1035965.66666666666662252.0USE1L
TgeneNBASchr2:43712372chr2:15523441ENST0000028151327521036_23711085.66666666666672372.0ZW10 and RINT1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THADA-NBAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THADA-NBAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource