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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THAP6-SETD2 (FusionGDB2 ID:90607)

Fusion Gene Summary for THAP6-SETD2

check button Fusion gene summary
Fusion gene informationFusion gene name: THAP6-SETD2
Fusion gene ID: 90607
HgeneTgene
Gene symbol

THAP6

SETD2

Gene ID

152815

29072

Gene nameTHAP domain containing 6SET domain containing 2, histone lysine methyltransferase
Synonyms-HBP231|HIF-1|HIP-1|HSPC069|HYPB|KMT3A|LLS|SET2|p231HBP
Cytomap

4q21.1

3p21.31

Type of geneprotein-codingprotein-coding
DescriptionTHAP domain-containing protein 6histone-lysine N-methyltransferase SETD2SET domain containing 2huntingtin interacting protein 1huntingtin yeast partner Bhuntingtin-interacting protein Blysine N-methyltransferase 3Aprotein-lysine N-methyltransferase SETD2
Modification date2020031320200315
UniProtAcc.

Q9BYW2

Ensembl transtripts involved in fusion geneENST00000311638, ENST00000380837, 
ENST00000502620, ENST00000504190, 
ENST00000507556, ENST00000507557, 
ENST00000507885, ENST00000508105, 
ENST00000514480, 		ENST00000492397, 
ENST00000409792, 
Fusion gene scores* DoF score5 X 5 X 3=7514 X 12 X 8=1344
# samples 517
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1344*10)=-2.98292648664106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THAP6 [Title/Abstract] AND SETD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHAP6(76442189)-SETD2(47061330), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSETD2

GO:0010569

regulation of double-strand break repair via homologous recombination

24843002

TgeneSETD2

GO:0018023

peptidyl-lysine trimethylation

27518565

TgeneSETD2

GO:0018026

peptidyl-lysine monomethylation

28753426

TgeneSETD2

GO:0032465

regulation of cytokinesis

27518565

TgeneSETD2

GO:0032727

positive regulation of interferon-alpha production

28753426

TgeneSETD2

GO:0034340

response to type I interferon

28753426

TgeneSETD2

GO:0051607

defense response to virus

28753426

TgeneSETD2

GO:0097198

histone H3-K36 trimethylation

23043551|24843002|26002201|27474439|28753426

TgeneSETD2

GO:0097676

histone H3-K36 dimethylation

26002201

TgeneSETD2

GO:1902850

microtubule cytoskeleton organization involved in mitosis

27518565

TgeneSETD2

GO:1905634

regulation of protein localization to chromatin

24843002


check buttonFusion gene breakpoints across THAP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SETD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GT-01ATHAP6chr4

76442189

+SETD2chr3

47061330

-


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Fusion Gene ORF analysis for THAP6-SETD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000311638ENST00000492397THAP6chr4

76442189

+SETD2chr3

47061330

-
5CDS-intronENST00000380837ENST00000492397THAP6chr4

76442189

+SETD2chr3

47061330

-
5CDS-intronENST00000502620ENST00000492397THAP6chr4

76442189

+SETD2chr3

47061330

-
5CDS-intronENST00000504190ENST00000492397THAP6chr4

76442189

+SETD2chr3

47061330

-
5CDS-intronENST00000507556ENST00000492397THAP6chr4

76442189

+SETD2chr3

47061330

-
5CDS-intronENST00000507557ENST00000492397THAP6chr4

76442189

+SETD2chr3

47061330

-
5CDS-intronENST00000507885ENST00000492397THAP6chr4

76442189

+SETD2chr3

47061330

-
5CDS-intronENST00000508105ENST00000492397THAP6chr4

76442189

+SETD2chr3

47061330

-
5CDS-intronENST00000514480ENST00000492397THAP6chr4

76442189

+SETD2chr3

47061330

-
In-frameENST00000311638ENST00000409792THAP6chr4

76442189

+SETD2chr3

47061330

-
In-frameENST00000380837ENST00000409792THAP6chr4

76442189

+SETD2chr3

47061330

-
In-frameENST00000502620ENST00000409792THAP6chr4

76442189

+SETD2chr3

47061330

-
In-frameENST00000504190ENST00000409792THAP6chr4

76442189

+SETD2chr3

47061330

-
In-frameENST00000507556ENST00000409792THAP6chr4

76442189

+SETD2chr3

47061330

-
In-frameENST00000507557ENST00000409792THAP6chr4

76442189

+SETD2chr3

47061330

-
In-frameENST00000507885ENST00000409792THAP6chr4

76442189

+SETD2chr3

47061330

-
In-frameENST00000508105ENST00000409792THAP6chr4

76442189

+SETD2chr3

47061330

-
In-frameENST00000514480ENST00000409792THAP6chr4

76442189

+SETD2chr3

47061330

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000507557THAP6chr476442189+ENST00000409792SETD2chr347061330-1034285120629169
ENST00000508105THAP6chr476442189+ENST00000409792SETD2chr347061330-100525691600169
ENST00000311638THAP6chr476442189+ENST00000409792SETD2chr347061330-110535668700210
ENST00000380837THAP6chr476442189+ENST00000409792SETD2chr347061330-110535668700210
ENST00000507556THAP6chr476442189+ENST00000409792SETD2chr347061330-110535668700210
ENST00000504190THAP6chr476442189+ENST00000409792SETD2chr347061330-100525691600169
ENST00000507885THAP6chr476442189+ENST00000409792SETD2chr347061330-100525691600169
ENST00000502620THAP6chr476442189+ENST00000409792SETD2chr347061330-99925085594169
ENST00000514480THAP6chr476442189+ENST00000409792SETD2chr347061330-15297804921124210

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000507557ENST00000409792THAP6chr476442189+SETD2chr347061330-0.0092562040.9907438
ENST00000508105ENST00000409792THAP6chr476442189+SETD2chr347061330-0.0089337780.99106616
ENST00000311638ENST00000409792THAP6chr476442189+SETD2chr347061330-0.0030064350.99699354
ENST00000380837ENST00000409792THAP6chr476442189+SETD2chr347061330-0.0030064350.99699354
ENST00000507556ENST00000409792THAP6chr476442189+SETD2chr347061330-0.0030064350.99699354
ENST00000504190ENST00000409792THAP6chr476442189+SETD2chr347061330-0.0089337780.99106616
ENST00000507885ENST00000409792THAP6chr476442189+SETD2chr347061330-0.0089337780.99106616
ENST00000502620ENST00000409792THAP6chr476442189+SETD2chr347061330-0.0103912950.9896087
ENST00000514480ENST00000409792THAP6chr476442189+SETD2chr347061330-0.0037189340.9962811

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Fusion Genomic Features for THAP6-SETD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THAP6-SETD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:76442189/chr3:47061330)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SETD2

Q9BYW2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (PubMed:19332550). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction (PubMed:23622243). Required for DNA double-strand break repair in response to DNA damage: acts by mediating formation of H3K36me3, promoting recruitment of RAD51 and DNA repair via homologous recombination (HR) (PubMed:24843002). Acts as a tumor suppressor (PubMed:24509477). H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A (PubMed:27317772). H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase (PubMed:21792193). Required during angiogenesis (By similarity). Required for endoderm development by promoting embryonic stem cell differentiation toward endoderm: acts by mediating formation of H3K36me3 in distal promoter regions of FGFR3, leading to regulate transcription initiation of FGFR3 (By similarity). In addition to histones, also mediates methylation of other proteins, such as tubulins and STAT1 (PubMed:27518565, PubMed:28753426). Trimethylates 'Lys-40' of alpha-tubulins such as TUBA1B (alpha-TubK40me3); alpha-TubK40me3 is required for normal mitosis and cytokinesis and may be a specific tag in cytoskeletal remodeling (PubMed:27518565). Involved in interferon-alpha-induced antiviral defense by mediating both monomethylation of STAT1 at 'Lys-525' and catalyzing H3K36me3 on promoters of some interferon-stimulated genes (ISGs) to activate gene transcription (PubMed:28753426). {ECO:0000250|UniProtKB:E9Q5F9, ECO:0000269|PubMed:16118227, ECO:0000269|PubMed:19141475, ECO:0000269|PubMed:21526191, ECO:0000269|PubMed:21792193, ECO:0000269|PubMed:23043551, ECO:0000269|PubMed:23325844, ECO:0000269|PubMed:23622243, ECO:0000269|PubMed:24509477, ECO:0000269|PubMed:24843002, ECO:0000269|PubMed:27317772, ECO:0000269|PubMed:27474439, ECO:0000269|PubMed:27518565, ECO:0000269|PubMed:28753426}.; FUNCTION: (Microbial infection) Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. {ECO:0000269|PubMed:11461154}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHAP6chr4:76442189chr3:47061330ENST00000311638+351_8996223.0Zinc fingerTHAP-type
HgeneTHAP6chr4:76442189chr3:47061330ENST00000380837+341_8996181.0Zinc fingerTHAP-type
HgeneTHAP6chr4:76442189chr3:47061330ENST00000514480+351_8996223.0Zinc fingerTHAP-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHAP6chr4:76442189chr3:47061330ENST00000311638+35149_19496223.0Coiled coilOntology_term=ECO:0000255
HgeneTHAP6chr4:76442189chr3:47061330ENST00000380837+34149_19496181.0Coiled coilOntology_term=ECO:0000255
HgeneTHAP6chr4:76442189chr3:47061330ENST00000514480+35149_19496223.0Coiled coilOntology_term=ECO:0000255
HgeneTHAP6chr4:76442189chr3:47061330ENST00000311638+35139_14296223.0MotifHCFC1-binding motif (HBM)
HgeneTHAP6chr4:76442189chr3:47061330ENST00000380837+34139_14296181.0MotifHCFC1-binding motif (HBM)
HgeneTHAP6chr4:76442189chr3:47061330ENST00000514480+35139_14296223.0MotifHCFC1-binding motif (HBM)
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217212117_214624502565.0Coiled coilOntology_term=ECO:0000255
TgeneSETD2chr4:76442189chr3:47061330ENST000004097921721166_24724502565.0Compositional biasNote=Pro-rich
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217212149_223224502565.0Compositional biasNote=Pro-rich
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217212266_236524502565.0Compositional biasNote=Gln-rich
TgeneSETD2chr4:76442189chr3:47061330ENST000004097921721385_45624502565.0Compositional biasNote=Arg-rich
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217211494_154824502565.0DomainAWS
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217211550_166724502565.0DomainSET
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217211674_169024502565.0DomainPost-SET
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217212389_242224502565.0DomainWW
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217211560_156224502565.0RegionS-adenosyl-L-methionine binding
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217211603_160524502565.0RegionS-adenosyl-L-methionine binding
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217211628_162924502565.0RegionS-adenosyl-L-methionine binding
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217212137_236624502565.0RegionLow charge region


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Fusion Gene Sequence for THAP6-SETD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90607_90607_1_THAP6-SETD2_THAP6_chr4_76442189_ENST00000311638_SETD2_chr3_47061330_ENST00000409792_length(transcript)=1105nt_BP=356nt
AGACGCAGTCTCCGTCGTTGACGTTAGTCGCAGTCTTCGCTGCTAACGTTTTGTTATGAGTTGCTAAAATGGTGAAATGCTGCTCCGCCA
TTGGATGTGCTTCTCGCTGCTTGCCAAATTCGAAGTTAAAAGGACTGACATTTCACGTATTCCCCACAGATGAAAACATCAAAAGGAAAT
GGGTATTAGCAATGAAAAGACTTGATGTGAATGCAGCCGGCATTTGGGAGCCTAAAAAAGGAGATGTGTTGTGTTCGAGGCACTTTAAGA
AGACAGATTTTGACAGAAGTGCTCCAAATATTAAACTGAAACCTGGAGTCATACCTTCTATCTTTGATTCTCCATATCACCTACAGGCCT
CGAAAAAGCCCAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCA
TCGTCCAGTGCCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGC
TGACTCACGGTGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGG
AGTACATTAAGAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGA
GGATGGGTGGTCAGGTAAGACAGACTCTAGGGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGAT
ACATCACCCTGGGGAATTCAACCCTGCAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTG
TTGGCATGTGGTTAGAAGCCATCAGAGGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCC
TTGGCGGTGCTGTCAGCGCACAGACCCATGCGCATCCCCACCCACAACCCTTTACCCTGATGATCTGTATTATATTTTAATGTATATGTG

>90607_90607_1_THAP6-SETD2_THAP6_chr4_76442189_ENST00000311638_SETD2_chr3_47061330_ENST00000409792_length(amino acids)=210AA_BP=96
MVKCCSAIGCASRCLPNSKLKGLTFHVFPTDENIKRKWVLAMKRLDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFD
SPYHLQASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNE

--------------------------------------------------------------
>90607_90607_2_THAP6-SETD2_THAP6_chr4_76442189_ENST00000380837_SETD2_chr3_47061330_ENST00000409792_length(transcript)=1105nt_BP=356nt
AGACGCAGTCTCCGTCGTTGACGTTAGTCGCAGTCTTCGCTGCTAACGTTTTGTTATGAGTTGCTAAAATGGTGAAATGCTGCTCCGCCA
TTGGATGTGCTTCTCGCTGCTTGCCAAATTCGAAGTTAAAAGGACTGACATTTCACGTATTCCCCACAGATGAAAACATCAAAAGGAAAT
GGGTATTAGCAATGAAAAGACTTGATGTGAATGCAGCCGGCATTTGGGAGCCTAAAAAAGGAGATGTGTTGTGTTCGAGGCACTTTAAGA
AGACAGATTTTGACAGAAGTGCTCCAAATATTAAACTGAAACCTGGAGTCATACCTTCTATCTTTGATTCTCCATATCACCTACAGGCCT
CGAAAAAGCCCAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCA
TCGTCCAGTGCCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGC
TGACTCACGGTGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGG
AGTACATTAAGAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGA
GGATGGGTGGTCAGGTAAGACAGACTCTAGGGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGAT
ACATCACCCTGGGGAATTCAACCCTGCAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTG
TTGGCATGTGGTTAGAAGCCATCAGAGGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCC
TTGGCGGTGCTGTCAGCGCACAGACCCATGCGCATCCCCACCCACAACCCTTTACCCTGATGATCTGTATTATATTTTAATGTATATGTG

>90607_90607_2_THAP6-SETD2_THAP6_chr4_76442189_ENST00000380837_SETD2_chr3_47061330_ENST00000409792_length(amino acids)=210AA_BP=96
MVKCCSAIGCASRCLPNSKLKGLTFHVFPTDENIKRKWVLAMKRLDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFD
SPYHLQASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNE

--------------------------------------------------------------
>90607_90607_3_THAP6-SETD2_THAP6_chr4_76442189_ENST00000502620_SETD2_chr3_47061330_ENST00000409792_length(transcript)=999nt_BP=250nt
AGTCTCCGTCGTTGACGTTAGTCGCAGTCTTCGCTGCTAACGATTCCCCACAGATGAAAACATCAAAAGGAAATGGGTATTAGCAATGAA
AAGACTTGATGTGAATGCAGCCGGCATTTGGGAGCCTAAAAAAGGAGATGTGTTGTGTTCGAGGCACTTTAAGAAGACAGATTTTGACAG
AAGTGCTCCAAATATTAAACTGAAACCTGGAGTCATACCTTCTATCTTTGATTCTCCATATCACCTACAGGCCTCGAAAAAGCCCAAGAC
AGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAA
CCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTAT
GAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTA
CATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGGTCAGGT
AAGACAGACTCTAGGGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCTGGGGAA
TTCAACCCTGCAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGCATGTGGTTAGA
AGCCATCAGAGGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCCTTGGCGGTGCTGTCAG
CGCACAGACCCATGCGCATCCCCACCCACAACCCTTTACCCTGATGATCTGTATTATATTTTAATGTATATGTGAATATATTGAAAATAA

>90607_90607_3_THAP6-SETD2_THAP6_chr4_76442189_ENST00000502620_SETD2_chr3_47061330_ENST00000409792_length(amino acids)=169AA_BP=55
MKRLDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFDSPYHLQASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQC

--------------------------------------------------------------
>90607_90607_4_THAP6-SETD2_THAP6_chr4_76442189_ENST00000504190_SETD2_chr3_47061330_ENST00000409792_length(transcript)=1005nt_BP=256nt
AGACGCAGTCTCCGTCGTTGACGTTAGTCGCAGTCTTCGCTGCTAACGATTCCCCACAGATGAAAACATCAAAAGGAAATGGGTATTAGC
AATGAAAAGACTTGATGTGAATGCAGCCGGCATTTGGGAGCCTAAAAAAGGAGATGTGTTGTGTTCGAGGCACTTTAAGAAGACAGATTT
TGACAGAAGTGCTCCAAATATTAAACTGAAACCTGGAGTCATACCTTCTATCTTTGATTCTCCATATCACCTACAGGCCTCGAAAAAGCC
CAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTG
CCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGG
TGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAA
GAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGG
TCAGGTAAGACAGACTCTAGGGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCT
GGGGAATTCAACCCTGCAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGCATGTG
GTTAGAAGCCATCAGAGGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCCTTGGCGGTGC
TGTCAGCGCACAGACCCATGCGCATCCCCACCCACAACCCTTTACCCTGATGATCTGTATTATATTTTAATGTATATGTGAATATATTGA

>90607_90607_4_THAP6-SETD2_THAP6_chr4_76442189_ENST00000504190_SETD2_chr3_47061330_ENST00000409792_length(amino acids)=169AA_BP=55
MKRLDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFDSPYHLQASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQC

--------------------------------------------------------------
>90607_90607_5_THAP6-SETD2_THAP6_chr4_76442189_ENST00000507556_SETD2_chr3_47061330_ENST00000409792_length(transcript)=1105nt_BP=356nt
AGACGCAGTCTCCGTCGTTGACGTTAGTCGCAGTCTTCGCTGCTAACGTTTTGTTATGAGTTGCTAAAATGGTGAAATGCTGCTCCGCCA
TTGGATGTGCTTCTCGCTGCTTGCCAAATTCGAAGTTAAAAGGACTGACATTTCACGTATTCCCCACAGATGAAAACATCAAAAGGAAAT
GGGTATTAGCAATGAAAAGACTTGATGTGAATGCAGCCGGCATTTGGGAGCCTAAAAAAGGAGATGTGTTGTGTTCGAGGCACTTTAAGA
AGACAGATTTTGACAGAAGTGCTCCAAATATTAAACTGAAACCTGGAGTCATACCTTCTATCTTTGATTCTCCATATCACCTACAGGCCT
CGAAAAAGCCCAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCA
TCGTCCAGTGCCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGC
TGACTCACGGTGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGG
AGTACATTAAGAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGA
GGATGGGTGGTCAGGTAAGACAGACTCTAGGGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGAT
ACATCACCCTGGGGAATTCAACCCTGCAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTG
TTGGCATGTGGTTAGAAGCCATCAGAGGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCC
TTGGCGGTGCTGTCAGCGCACAGACCCATGCGCATCCCCACCCACAACCCTTTACCCTGATGATCTGTATTATATTTTAATGTATATGTG

>90607_90607_5_THAP6-SETD2_THAP6_chr4_76442189_ENST00000507556_SETD2_chr3_47061330_ENST00000409792_length(amino acids)=210AA_BP=96
MVKCCSAIGCASRCLPNSKLKGLTFHVFPTDENIKRKWVLAMKRLDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFD
SPYHLQASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNE

--------------------------------------------------------------
>90607_90607_6_THAP6-SETD2_THAP6_chr4_76442189_ENST00000507557_SETD2_chr3_47061330_ENST00000409792_length(transcript)=1034nt_BP=285nt
TCCCGGGGCTACGAGGCGGAAGCGAAGGCAGACGCAGTCTCCGTCGTTGACGTTAGTCGCAGTCTTCGCTGCTAACGATTCCCCACAGAT
GAAAACATCAAAAGGAAATGGGTATTAGCAATGAAAAGACTTGATGTGAATGCAGCCGGCATTTGGGAGCCTAAAAAAGGAGATGTGTTG
TGTTCGAGGCACTTTAAGAAGACAGATTTTGACAGAAGTGCTCCAAATATTAAACTGAAACCTGGAGTCATACCTTCTATCTTTGATTCT
CCATATCACCTACAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGA
AAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTT
AAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAAT
GTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGA
CTGTTGGGCCAGGGTGGGAGGATGGGTGGTCAGGTAAGACAGACTCTAGGGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCA
GCACTGTGCTACTGATGATACATCACCCTGGGGAATTCAACCCTGCAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTG
ATTACCTAGTTGTGAGCTGTTGGCATGTGGTTAGAAGCCATCAGAGGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTC
TTAAACCTGGGTCTTCTCCTTGGCGGTGCTGTCAGCGCACAGACCCATGCGCATCCCCACCCACAACCCTTTACCCTGATGATCTGTATT

>90607_90607_6_THAP6-SETD2_THAP6_chr4_76442189_ENST00000507557_SETD2_chr3_47061330_ENST00000409792_length(amino acids)=169AA_BP=55
MKRLDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFDSPYHLQASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQC

--------------------------------------------------------------
>90607_90607_7_THAP6-SETD2_THAP6_chr4_76442189_ENST00000507885_SETD2_chr3_47061330_ENST00000409792_length(transcript)=1005nt_BP=256nt
AGACGCAGTCTCCGTCGTTGACGTTAGTCGCAGTCTTCGCTGCTAACGATTCCCCACAGATGAAAACATCAAAAGGAAATGGGTATTAGC
AATGAAAAGACTTGATGTGAATGCAGCCGGCATTTGGGAGCCTAAAAAAGGAGATGTGTTGTGTTCGAGGCACTTTAAGAAGACAGATTT
TGACAGAAGTGCTCCAAATATTAAACTGAAACCTGGAGTCATACCTTCTATCTTTGATTCTCCATATCACCTACAGGCCTCGAAAAAGCC
CAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTG
CCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGG
TGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAA
GAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGG
TCAGGTAAGACAGACTCTAGGGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCT
GGGGAATTCAACCCTGCAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGCATGTG
GTTAGAAGCCATCAGAGGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCCTTGGCGGTGC
TGTCAGCGCACAGACCCATGCGCATCCCCACCCACAACCCTTTACCCTGATGATCTGTATTATATTTTAATGTATATGTGAATATATTGA

>90607_90607_7_THAP6-SETD2_THAP6_chr4_76442189_ENST00000507885_SETD2_chr3_47061330_ENST00000409792_length(amino acids)=169AA_BP=55
MKRLDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFDSPYHLQASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQC

--------------------------------------------------------------
>90607_90607_8_THAP6-SETD2_THAP6_chr4_76442189_ENST00000508105_SETD2_chr3_47061330_ENST00000409792_length(transcript)=1005nt_BP=256nt
AGACGCAGTCTCCGTCGTTGACGTTAGTCGCAGTCTTCGCTGCTAACGATTCCCCACAGATGAAAACATCAAAAGGAAATGGGTATTAGC
AATGAAAAGACTTGATGTGAATGCAGCCGGCATTTGGGAGCCTAAAAAAGGAGATGTGTTGTGTTCGAGGCACTTTAAGAAGACAGATTT
TGACAGAAGTGCTCCAAATATTAAACTGAAACCTGGAGTCATACCTTCTATCTTTGATTCTCCATATCACCTACAGGCCTCGAAAAAGCC
CAAGACAGCAGAAGCAGACACCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTG
CCTGAACCCTTACCGGAAACCTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGG
TGTTATGAATAAGGAGCTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAA
GAAGTACATGCAGAAGTTTGGGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGG
TCAGGTAAGACAGACTCTAGGGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCT
GGGGAATTCAACCCTGCAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGCATGTG
GTTAGAAGCCATCAGAGGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCCTTGGCGGTGC
TGTCAGCGCACAGACCCATGCGCATCCCCACCCACAACCCTTTACCCTGATGATCTGTATTATATTTTAATGTATATGTGAATATATTGA

>90607_90607_8_THAP6-SETD2_THAP6_chr4_76442189_ENST00000508105_SETD2_chr3_47061330_ENST00000409792_length(amino acids)=169AA_BP=55
MKRLDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFDSPYHLQASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQC

--------------------------------------------------------------
>90607_90607_9_THAP6-SETD2_THAP6_chr4_76442189_ENST00000514480_SETD2_chr3_47061330_ENST00000409792_length(transcript)=1529nt_BP=780nt
GGTAATAACTCTTAGGTTGCCTGTTTTCCCCCAATCGCTACCCGCCCAAATCTCAGGGCGTAGTTCGGCGCGAGGTTGGCGGCAGCGGCG
CGGAGACGCTGGTTGGCCCCAGAGGAAAGGACGCTCACTGGGCGCATCGTTACCTGTGACGGGTCCTCCCTCTCTCCCTCCGGTGGCGGG
GAGCCTGGAGAAAGGGGCGGAGCTCGGCCCGGGCCCTGGGCTCAGCGGGTCCCGCGCGCTGCTCTTGGACGCCAGGGTGCTCGCTGGCAC
CTCGAAGTGCTTCTTGCTTCCTCCCTTTCCCGTTTACTTGCTGTTCTTTCAAAATATGTACTGACATTCACTATTGCCAGTCACCAGCTA
AACCGTGAGGACAAAAAGTAAGGAAAAATAGACACACTCCACCATGACCTCATGGAACTAACAAGACTGGTGGAGGAGGAAGACATTAAT
AAGAGCAATCACTGCAATAAATTTTTGTTATGAGTTGCTAAAATGGTGAAATGCTGCTCCGCCATTGGATGTGCTTCTCGCTGCTTGCCA
AATTCGAAGTTAAAAGGACTGACATTTCACGTATTCCCCACAGATGAAAACATCAAAAGGAAATGGGTATTAGCAATGAAAAGACTTGAT
GTGAATGCAGCCGGCATTTGGGAGCCTAAAAAAGGAGATGTGTTGTGTTCGAGGCACTTTAAGAAGACAGATTTTGACAGAAGTGCTCCA
AATATTAAACTGAAACCTGGAGTCATACCTTCTATCTTTGATTCTCCATATCACCTACAGGCCTCGAAAAAGCCCAAGACAGCAGAAGCA
GACACCTCCAGTGAACTAGCAAAGAAAAGCAAAGAAGTATTCAGAAAAGAGATGTCCCAGTTCATCGTCCAGTGCCTGAACCCTTACCGG
AAACCTGACTGCAAAGTGGGAAGAATTACCACAACTGAAGACTTTAAACATCTGGCTCGCAAGCTGACTCACGGTGTTATGAATAAGGAG
CTGAAGTACTGTAAGAATCCTGAGGACCTGGAGTGCAATGAGAATGTGAAACACAAAACCAAGGAGTACATTAAGAAGTACATGCAGAAG
TTTGGGGCTGTTTACAAACCCAAAGAGGACACTGAATTAGAGTGACTGTTGGGCCAGGGTGGGAGGATGGGTGGTCAGGTAAGACAGACT
CTAGGGAGAGGAAATCCTGTGGGCCTTTCTGTCCCACCCCTGTCAGCACTGTGCTACTGATGATACATCACCCTGGGGAATTCAACCCTG
CAGATGTCAACTGAAGGCCACAAAAATGAACTCCATCTACAAGTGATTACCTAGTTGTGAGCTGTTGGCATGTGGTTAGAAGCCATCAGA
GGTGCAAGGGCTTAGAAAAGACCCTGGCCAGACCTGACTCCACTCTTAAACCTGGGTCTTCTCCTTGGCGGTGCTGTCAGCGCACAGACC

>90607_90607_9_THAP6-SETD2_THAP6_chr4_76442189_ENST00000514480_SETD2_chr3_47061330_ENST00000409792_length(amino acids)=210AA_BP=96
MVKCCSAIGCASRCLPNSKLKGLTFHVFPTDENIKRKWVLAMKRLDVNAAGIWEPKKGDVLCSRHFKKTDFDRSAPNIKLKPGVIPSIFD
SPYHLQASKKPKTAEADTSSELAKKSKEVFRKEMSQFIVQCLNPYRKPDCKVGRITTTEDFKHLARKLTHGVMNKELKYCKNPEDLECNE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for THAP6-SETD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217212457_25642450.02565.0POLR2A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSETD2chr4:76442189chr3:47061330ENST0000040979217211418_17142450.02565.0TUBA1A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THAP6-SETD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THAP6-SETD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource