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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THEMIS-SLK (FusionGDB2 ID:90646)

Fusion Gene Summary for THEMIS-SLK

check button Fusion gene summary
Fusion gene informationFusion gene name: THEMIS-SLK
Fusion gene ID: 90646
HgeneTgene
Gene symbol

THEMIS

SLK

Gene ID

387357

9748

Gene namethymocyte selection associatedSTE20 like kinase
SynonymsC6orf190|C6orf207|GASP|SPOT|TSEPALOSK|STK2|bA16H23.1|se20-9
Cytomap

6q22.33

10q24.33-q25.1

Type of geneprotein-codingprotein-coding
Descriptionprotein THEMISGRB2-associated proteinsignaling phosphoprotein specific for T cellsthymocyte selection pathway associatedthymocyte-expressed molecule involved in selectionSTE20-like serine/threonine-protein kinaseCTCL tumor antigen se20-9Long Ste20-like KinaseSNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinaseSNF1 sucrose nonfermenting like kinaseSTE20-related kinaseSTE20-
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000368248, ENST00000543064, 
ENST00000368250, ENST00000537166, 
ENST00000474260, ENST00000335753, 
ENST00000369755, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: THEMIS [Title/Abstract] AND SLK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHEMIS(128221986)-SLK(105750432), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLK

GO:0042981

regulation of apoptotic process

22203681

TgeneSLK

GO:0046777

protein autophosphorylation

18239682

TgeneSLK

GO:0051893

regulation of focal adhesion assembly

23128389


check buttonFusion gene breakpoints across THEMIS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A4A9THEMISchr6

128221986

-SLKchr10

105750432

+


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Fusion Gene ORF analysis for THEMIS-SLK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000368248ENST00000474260THEMISchr6

128221986

-SLKchr10

105750432

+
5CDS-intronENST00000543064ENST00000474260THEMISchr6

128221986

-SLKchr10

105750432

+
5UTR-3CDSENST00000368250ENST00000335753THEMISchr6

128221986

-SLKchr10

105750432

+
5UTR-3CDSENST00000368250ENST00000369755THEMISchr6

128221986

-SLKchr10

105750432

+
5UTR-intronENST00000368250ENST00000474260THEMISchr6

128221986

-SLKchr10

105750432

+
In-frameENST00000368248ENST00000335753THEMISchr6

128221986

-SLKchr10

105750432

+
In-frameENST00000368248ENST00000369755THEMISchr6

128221986

-SLKchr10

105750432

+
In-frameENST00000543064ENST00000335753THEMISchr6

128221986

-SLKchr10

105750432

+
In-frameENST00000543064ENST00000369755THEMISchr6

128221986

-SLKchr10

105750432

+
intron-3CDSENST00000537166ENST00000335753THEMISchr6

128221986

-SLKchr10

105750432

+
intron-3CDSENST00000537166ENST00000369755THEMISchr6

128221986

-SLKchr10

105750432

+
intron-intronENST00000537166ENST00000474260THEMISchr6

128221986

-SLKchr10

105750432

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368248THEMISchr6128221986-ENST00000369755SLKchr10105750432+731124023437971187
ENST00000368248THEMISchr6128221986-ENST00000335753SLKchr10105750432+721824023437041156
ENST00000543064THEMISchr6128221986-ENST00000369755SLKchr10105750432+731124023437971187
ENST00000543064THEMISchr6128221986-ENST00000335753SLKchr10105750432+721824023437041156

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368248ENST00000369755THEMISchr6128221986-SLKchr10105750432+0.0002808960.9997191
ENST00000368248ENST00000335753THEMISchr6128221986-SLKchr10105750432+0.000351450.9996486
ENST00000543064ENST00000369755THEMISchr6128221986-SLKchr10105750432+0.0002808960.9997191
ENST00000543064ENST00000335753THEMISchr6128221986-SLKchr10105750432+0.000351450.9996486

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Fusion Genomic Features for THEMIS-SLK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
THEMISchr6128221986-SLKchr10105750432+4.82E-060.99999523
THEMISchr6128221986-SLKchr10105750432+4.82E-060.99999523

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for THEMIS-SLK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:128221986/chr10:105750432)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLKchr6:128221986chr10:105750432ENST000003357530181109_1183501205.0Coiled coilOntology_term=ECO:0000255
TgeneSLKchr6:128221986chr10:105750432ENST00000335753018826_1069501205.0Coiled coilOntology_term=ECO:0000255
TgeneSLKchr6:128221986chr10:105750432ENST000003697550191109_1183501236.0Coiled coilOntology_term=ECO:0000255
TgeneSLKchr6:128221986chr10:105750432ENST00000369755019826_1069501236.0Coiled coilOntology_term=ECO:0000255
TgeneSLKchr6:128221986chr10:105750432ENST00000335753018302_652501205.0Compositional biasNote=Glu-rich
TgeneSLKchr6:128221986chr10:105750432ENST00000369755019302_652501236.0Compositional biasNote=Glu-rich
TgeneSLKchr6:128221986chr10:105750432ENST00000335753018875_910501205.0DomainUVR
TgeneSLKchr6:128221986chr10:105750432ENST00000369755019875_910501236.0DomainUVR

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHEMISchr6:128221986chr10:105750432ENST00000368248-161_25930642.0RegionNote=CABIT 1
HgeneTHEMISchr6:128221986chr10:105750432ENST00000368248-16260_51830642.0RegionNote=CABIT 2
HgeneTHEMISchr6:128221986chr10:105750432ENST00000537166-161_2590607.0RegionNote=CABIT 1
HgeneTHEMISchr6:128221986chr10:105750432ENST00000537166-16260_5180607.0RegionNote=CABIT 2
TgeneSLKchr6:128221986chr10:105750432ENST0000033575301816_19501205.0Compositional biasNote=Poly-Lys
TgeneSLKchr6:128221986chr10:105750432ENST0000036975501916_19501236.0Compositional biasNote=Poly-Lys
TgeneSLKchr6:128221986chr10:105750432ENST0000033575301834_292501205.0DomainProtein kinase
TgeneSLKchr6:128221986chr10:105750432ENST0000036975501934_292501236.0DomainProtein kinase
TgeneSLKchr6:128221986chr10:105750432ENST0000033575301840_48501205.0Nucleotide bindingATP
TgeneSLKchr6:128221986chr10:105750432ENST0000036975501940_48501236.0Nucleotide bindingATP


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Fusion Gene Sequence for THEMIS-SLK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90646_90646_1_THEMIS-SLK_THEMIS_chr6_128221986_ENST00000368248_SLK_chr10_105750432_ENST00000335753_length(transcript)=7218nt_BP=240nt
AGCTACTCCACCCCACTCTGGCTGTAGTGTGACATTCCTGCCTGCCTGAGGAAGAAATGGTGAGCAGGGGCTGCAATTGCAGACAAGTGT
CACCCAGAAGCCACAAGTTTCTGTGAGCACCAGGTCTACAAACTACCCAAGGCATAGCAATGGCATTATCACTGGAAGAATTCGTCCACT
CCCTTGACCTCAGGACCCTACCCAGGGTTCTAGAAATCCAGGCAGGCATCTATCTTGAAGGCCCAGAATAAAGAGACCAGTGTTTTAGCT
GCTGCAAAAGTGATTGACACTAAATCTGAAGAAGAACTTGAAGATTACATGGTAGAGATTGACATATTAGCATCTTGTGATCACCCAAAT
ATAGTCAAGCTTCTAGATGCCTTCTATTATGAGAACAATCTTTGGATCCTCATTGAATTTTGTGCAGGTGGAGCAGTAGATGCTGTGATG
CTTGAACTTGAGAGACCATTAACTGAGTCCCAAATACAAGTAGTTTGCAAGCAGACTTTAGATGCATTGAACTACTTACATGATAATAAG
ATCATCCACAGAGATCTGAAGGCTGGCAACATTCTCTTTACCTTAGATGGAGATATCAAATTGGCGGATTTTGGAGTATCAGCTAAAAAC
ACGAGGACAATTCAAAGAAGAGATTCCTTTATTGGTACACCATATTGGATGGCTCCTGAAGTAGTCATGTGTGAAACATCTAAGGACAGA
CCCTATGACTACAAAGCTGATGTTTGGTCCCTGGGTATCACTTTAATAGAAATGGCTGAGATAGAACCACCTCATCATGAATTAAATCCA
ATGCGAGTGCTGCTAAAAATAGCAAAATCTGAGCCACCTACATTAGCACAGCCATCCAGATGGTCTTCAAATTTTAAGGACTTTCTAAAG
AAATGCTTAGAAAAGAATGTGGATGCCAGGTGGACTACATCTCAGCTGCTGCAGCATCCCTTTGTTACTGTTGATTCCAACAAACCCATC
CGAGAATTGATTGCAGAGGCGAAGGCTGAAGTAACAGAAGAAGTTGAAGATGGCAAAGAGGAAGATGAAGAGGAGGAAACAGAAAATTCT
CTGCCAATACCTGCAAGTAAGCGTGCATCTTCTGACCTTAGTATCGCCAGCTCTGAAGAAGATAAACTTTCACAAAATGCTTGTATTTTG
GAGTCTGTCTCAGAAAAAACAGAACGTAGTAACTCTGAAGATAAACTCAACAGCAAAATTCTTAATGAAAAACCCACCACTGATGAACCT
GAAAAGGCTGTGGAGGATATTAATGAACATATTACCGATGCTCAGTTAGAAGCAATGACTGAACTCCATGACAGAACAGCAGTAATCAAG
GAGAATGAAAGAGAGAAGAGGCCCAAGCTTGAAAATCTGCCTGACACAGAAGACCAAGAAACTGTGGACATTAATTCAGTCAGTGAAGGA
AAAGAGAATAATATAATGATAACCTTAGAAACAAATATTGAACATAATCTAAAATCTGAGGAAGAAAAGGATCAGGAAAAGCAACAGATG
TTTGAAAATAAGCTTATAAAATCTGAAGAAATTAAAGATACTATTTTGCAAACAGTAGATTTAGTTTCTCAAGAGACTGGAGAAAAAGAG
GCAAATATTCAGGCAGTTGATAGTGAAGTTGGGCTTACAAAGGAAGACACCCAAGAGAAATTGGGGGAAGACGACAAAACTCAAAAAGAT
GTGATCAGCAATACAAGTGATGTGATAGGAACATGTGAGGCAGCAGATGTGGCTCAGAAAGTGGATGAAGACAGTGCTGAGGATACGCAG
AGTAATGATGGGAAAGAAGTGGTCGAAGTAGGCCAGAAATTAATTAATAAGCCCATGGTGGGTCCTGAGGCTGGTGGTACTAAGGAAGTT
CCTATTAAAGAAATAGTTGAAATGAATGAAATAGAAGAAGGTAAAAATAAGGAACAAGCAATAAACAGTTCAGAGAACATAATGGACATC
AATGAGGAACCAGGAACAACTGAAGGTGAAGAAATCACTGAGTCAAGTAGCACTGAAGAAATGGAGGTCAGAAGTGTGGTGGCTGATACT
GACCAAAAGGCTTTAGGAAGTGAAGTTCAGGATGCTTCTAAAGTCACTACTCAGATAGATAAAGAGAAAAAAGAAATTCCAGTGTCAATT
AAAAAAGAGCCTGAAGTTACTGTAGTTTCACAGCCCACTGAACCTCAGCCTGTTCTAATACCCAGTATTAATATCAACTCTGACAGTGGA
GAAAATAAAGAAGAAATAGGTTCTTTATCAAAAACTGAAACTATTCTGCCACCAGAATCTGAGAATCCAAAGGAAAATGATAATGATTCA
GGCACTGGTTCCACTGCTGATACTAGCAGTATTGACTTGAATTTATCCATCTCTAGCTTTCTAAGTAAAACTAAAGACAGTGGATCGATA
TCTTTACAAGAAACAAGAAGACAAAAGAAAACATTGAAGAAAACACGCAAATTTATTGTTGATGGTGTAGAAGTGAGTGTAACAACATCA
AAGATAGTTACAGATAGTGATTCCAAAACTGAAGAATTGCGGTTTCTTAGACGTCAGGAACTTCGGGAATTAAGATTTCTTCAGAAAGAA
GAGCAAAGAGCCCAACAACAGCTCAATAGCAAACTACAGCAACAACGAGAACAAATTTTCCGGCGCTTTGAGCAGGAAATGATGAGTAAA
AAGCGACAATATGACCAGGAAATTGAGAATCTAGAAAAACAGCAGAAACAGACTATCGAACGCCTGGAACAAGAGCACACAAATCGCTTG
CGAGATGAAGCCAAACGCATCAAAGGAGAACAAGAGAAAGAGTTGTCCAAATTTCAGAATATGCTGAAGAACCGAAAGAAGGAGGAACAA
GAGTTTGTTCAGAAACAACAGCAAGAATTAGATGGCTCTCTGAAAAAGATCATCCAGCAGCAGAAGGCAGAGTTAGCTAATATTGAGAGA
GAGTGCCTGAATAACAAGCAACAGCTCATGAGAGCTCGAGAAGCTGCAATTTGGGAGCTCGAAGAACGACACTTACAAGAAAAACACCAG
CTGCTCAAACAGCAGCTTAAAGATCAGTATTTCATGCAAAGACATCAGCTACTTAAGCGCCACGAGAAGGAAACAGAGCAAATGCAGCGT
TACAATCAAAGACTTATTGAGGAATTGAAAAACAGACAGACTCAAGAAAGAGCAAGACTGCCCAAGATTCAGCGCAGTGAAGCCAAGACT
CGAATGGCCATGTTTAAGAAGAGTTTGAGAATTAACTCAACAGCCACACCAGATCAGGACCGTGATAAAATTAAACAGTTTGCTGCACAA
GAAGAAAAGAGGCAGAAAAATGAGAGAATGGCTCAGCATCAGAAACATGAGAATCAAATGCGAGATCTTCAGTTGCAGTGTGAAGCCAAT
GTCCGCGAACTGCATCAGCTGCAGAATGAAAAATGCCACTTGTTGGTTGAGCATGAGACTCAGAAACTGAAGGAGTTAGATGAGGAACAT
AGCCAAGAATTAAAGGAGTGGAGAGAGAAATTGAGACCTAGGAAAAAGACACTGGAAGAAGAGTTTGCCAGGAAACTACAGGAACAGGAA
GTATTCTTTAAAATGACTGGGGAGTCTGAATGCCTTAACCCATCAACACAGAGCCGGATTTCCAAATTTTATCCTATTCCCAGCTTGCAT
TCCACCGGATCATAACAAAGGGAAGCATTCTGTGCGTGGGTTTGGCTCTTTCAGTATGTCATTCTGTTCTCATCTTCTGCCACAGTCTCT
CAGATAGCTCATGAAGACAATCACCTGCCTCACCTTCTAGGTGTTTTCCTTTTTTGTTTTTTTTGTTTTGTTTTGTTTTTAAGCAAAGAT
GAAGGGAAAACGAACTAAGACAGACGCTAGGCCATGTTGGCAAAGTAGCATCTTGGTGACTAAGGTGACTTTGTATATTCATCTTAAAAA
TTATGTTCTTTAGACACTGCTACCTGAAAACTGTTGGAGAAATAATGTTTAAAGTTATTTAAGAAAAACTGTTACATCACTAAGTATTAA
TAAATTCTTCTTACCTGACGTAACTTCTCAATGCCTAAATTCTGTAGTTGAAGCTCTGCTGCAGAGAGTTGGGATAATTTTCTTTTGGTG
GATCAGCTCTCATAAAAAAGCTATGATTTGCTCAAATATGCTGTTGACTCAGTAAATGAATATATTTTTTTCTTTAAATAGGAACAACCT
CTTTTAAAAGAGAAAAATTATTTCAGTGATTTGTCAAAACGAATTACCTCTTTTGGCATGAGCTAATAATTGAGGGTGCTAATTTTCTTA
AGATAGTGCCTAAAACACTAAATTTCAGTCAAGTCGTAAGTAGGATTTTCTTTTTGATCAACAGGGACAAAAACATCTTTAGAATTAAAA
ACATGGTTGTTTTGGAATTTTTGCTTCTCTTACCGTTTGATAGAAATTTTCATCCTAAAATACATGTACAAAGTTTGGAAAGATGAAAAA
AAGAGGTAGCTTTTAGATTGCAAACTGGAAATGTAAAACTCATGAAATTTAAGCAATATAGGTTTAGCTATCTGTGTTTATTTTCTAAAA
TAATACCTGAGCTGGTTAAATGATTTCTCTCCATCTTAGCTAATTCTGTTTAAAACTCTGTCAGAGGCCTGCAGGCTGTGAGTTATATTT
ATAAATATATCTTCAGAAATTAATCTTAAAAGAGGCATTAGTTCAGAATACTTTTTTAAAAGTTTAAATTAAATATTTAGGCACGTCAGG
AATTACTTTTCCTTATTTTGAAATGAGGCTACTTATGTCTTGGTTTTATTTTGTTCCATGTTTAAATCATTCACTTTGATTTGAGTGGGA
AAAGCCTGAAGCCTTTATCATGTGGTTGCTGGTGTGTGTAATTATTAATGAAATGTTCACTCCTAGTCCCTTATGAGGCTTAGAATTTCA
ACCACGTGTCAGGTCAGACAGTATTATAAACTGTACTTTGCTGTCTGAGACAGCACATTTGTGAATGATGCTTGCTGCCTGCCATTTTCA
ACCTATTCTCTCTTAAGAGTGCTAGGTACCAAATTGTGAAAGTTTGTTTTCAGTTATATTACTTTTGAGGCTGGTGAAAAATTTAAATGT
AACTTTGTGGGAACACTGATTCATATTTAGAAAATGTAAATGTCTGTAGCACTTTCTTGCAGTTAATTTGAAAACTTTGGATGCTGAACC
TTGTTTGTCAGTGATTTAGATGATTTAAAAATGCATGTGTGATTTGAATTTTATAATTGTTTTGACAAGCATAATTTACTTGGACAACTT
CGTAGGTAGCCTTAACTTCTGGCCAAGTTTGTTTTTTATATAAATATATATACATATATACATATTATGTATGGTTGTAAATTCATACAC
TTATCACATGAATGTGTTACTGTATACAAAACTCTTAATGCTTTATTCTCAAATGCTGGGTTGAAAAATGTTTTGAAAGCCTTTTAAAAT
ATATATCTTTATAAAGTAATATTCAGGATGATGATAAAAATTGTTTATATTGTTATGATAAAAATGACAGTATAATGTTGCCCAGTGTAT
TTAATGATTTATTTGAAGAGGGATTGGGAAGGAACGTCTTCATACCACTTTCTCCTTTGAAATTTTCAGTTTATTGACTTTTAAAAAATG
AATACCTCAGGCAGTAGACATTTTTTTTCTAGTATCATTTAATTGATACCCTGTGCGCTAAATAGTGTGTGGTGCCTGATTAATTTGGTC
TGAATATTTGATTCTTTCTGTTCCTTTCAACTTGACATTCAGATTATTGACTCAAGGAGAGAGGCTCAGAGTGGAATGGTTGGCGCTGTG
GGTAAGGTTGGATCTCCCTTAAAACTGCCTTTTGGATTCAGTGTTTGTGCTTGAGTTCGCTTTCAAATATGACCATAATCGTGTGGGTGC
AAGACTGTACAGTGATACATATGTAGAGGTAAAGCATTCATTTTAATACTTAAAGTTATATAAATCTTTTCAAAAAGTGTTTTGTTATAA
AATACGCTGTTTGTACCCATACCAGCCCACCTCTTCTGAGGCCCTGTATTCAAATAGATGATAGTGATCTATCTTTCCTGCATGAAGTGT
AGGTGGCGAGTGGGCGAGGGGCGCAGACTTCTTTGAAATCGAAGGGTACAGTCAAATCTACTGCTGATTTGGTTGTTTTGTTGCTGTGGC
AGAATATGCCATGAAACACATACAGACTTCTCCGAACGTGCACCCTCATCAGCCACCTCCTCCCCTCTTTCCCTGAGTGCTGTGAACACA
GCAGACCTGCACACTTCTGCAGATCCAGCTCCTACAGCTTGGGGCACTAGGCTGCCTTTCCTAGTCCTGTCAACAACCATACAGTGCGAA
TTGCTGAATTAGCTGCTATTCTATGTGGAGTCACATTAAGCTTTTTCTTATCTTTTTCTATGGGGAAGCTATAGGGTGGGTAAGGAAAAA
ATGTTGAATGCTTTTACTTTGCTGAAAATATTAGAACTCTCTTGTGACAGGATACAGCAAATTATAATTAAATATAAATTACCAGAACCA
GAGCTACCTCTAAGTCATACTTCCTCAAGCACAAAGCTCTCAGGCATATGAGACCCACCTTAATGAAGGGTCTCTGATTTCTTGAGCATC
AGCGAGTTTCAGAAGTGACTATTTTTTTGTACTCTTCTAGTTTCCTTGTAACTATACACTTTTTCCCATTCCACACTGTGCTTAAATGAC
AAAGACTCTTCTGAGAAGCCAAATTCTGTCCAAGTATTAACTAGAGATATTGTTGATTAAAGAAAATCTAGAACTGAAGTGAAAGAAGAG
AGTTCCAGTTCTAATAGTCTTTTGATTAACAATTCTTTTCTGAGAAATGATTTTTATAAGAAATGGGGTGATTCTTTAAATGCTTTTCTT
AAGTTGAAGGCACAACAGTTAATGGCTGTATTGTTGCTATTCCGTTGCTGACATGTTTTTGATAAAGCTTTAACATTCCTGCTACTAATT
TTGGCGGAGAGTGTTTGCCAGGTTTCAATGTGGGCTGCAGCTTTTTGTGCTCCTTCTCTGGTTTGCAGTGTAATGAGTTCATAAGCTAAA
TTTTCAGAAAGAATTTTGTTTAAGATTATGCCTCTTATCTACTTGAGAGCAACATGTCTTTTCAATCATGGGATTGACACATGAAAAATA

>90646_90646_1_THEMIS-SLK_THEMIS_chr6_128221986_ENST00000368248_SLK_chr10_105750432_ENST00000335753_length(amino acids)=1156AA_BP=2
MKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQ
TLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEM
AEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDG
KEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEA
MTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQT
VDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKP
MVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQ
IDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSIS
SFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQ
IFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEEQEFVQKQQQELDGSLKKII
QQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERA
RLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEH

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>90646_90646_2_THEMIS-SLK_THEMIS_chr6_128221986_ENST00000368248_SLK_chr10_105750432_ENST00000369755_length(transcript)=7311nt_BP=240nt
AGCTACTCCACCCCACTCTGGCTGTAGTGTGACATTCCTGCCTGCCTGAGGAAGAAATGGTGAGCAGGGGCTGCAATTGCAGACAAGTGT
CACCCAGAAGCCACAAGTTTCTGTGAGCACCAGGTCTACAAACTACCCAAGGCATAGCAATGGCATTATCACTGGAAGAATTCGTCCACT
CCCTTGACCTCAGGACCCTACCCAGGGTTCTAGAAATCCAGGCAGGCATCTATCTTGAAGGCCCAGAATAAAGAGACCAGTGTTTTAGCT
GCTGCAAAAGTGATTGACACTAAATCTGAAGAAGAACTTGAAGATTACATGGTAGAGATTGACATATTAGCATCTTGTGATCACCCAAAT
ATAGTCAAGCTTCTAGATGCCTTCTATTATGAGAACAATCTTTGGATCCTCATTGAATTTTGTGCAGGTGGAGCAGTAGATGCTGTGATG
CTTGAACTTGAGAGACCATTAACTGAGTCCCAAATACAAGTAGTTTGCAAGCAGACTTTAGATGCATTGAACTACTTACATGATAATAAG
ATCATCCACAGAGATCTGAAGGCTGGCAACATTCTCTTTACCTTAGATGGAGATATCAAATTGGCGGATTTTGGAGTATCAGCTAAAAAC
ACGAGGACAATTCAAAGAAGAGATTCCTTTATTGGTACACCATATTGGATGGCTCCTGAAGTAGTCATGTGTGAAACATCTAAGGACAGA
CCCTATGACTACAAAGCTGATGTTTGGTCCCTGGGTATCACTTTAATAGAAATGGCTGAGATAGAACCACCTCATCATGAATTAAATCCA
ATGCGAGTGCTGCTAAAAATAGCAAAATCTGAGCCACCTACATTAGCACAGCCATCCAGATGGTCTTCAAATTTTAAGGACTTTCTAAAG
AAATGCTTAGAAAAGAATGTGGATGCCAGGTGGACTACATCTCAGCTGCTGCAGCATCCCTTTGTTACTGTTGATTCCAACAAACCCATC
CGAGAATTGATTGCAGAGGCGAAGGCTGAAGTAACAGAAGAAGTTGAAGATGGCAAAGAGGAAGATGAAGAGGAGGAAACAGAAAATTCT
CTGCCAATACCTGCAAGTAAGCGTGCATCTTCTGACCTTAGTATCGCCAGCTCTGAAGAAGATAAACTTTCACAAAATGCTTGTATTTTG
GAGTCTGTCTCAGAAAAAACAGAACGTAGTAACTCTGAAGATAAACTCAACAGCAAAATTCTTAATGAAAAACCCACCACTGATGAACCT
GAAAAGGCTGTGGAGGATATTAATGAACATATTACCGATGCTCAGTTAGAAGCAATGACTGAACTCCATGACAGAACAGCAGTAATCAAG
GAGAATGAAAGAGAGAAGAGGCCCAAGCTTGAAAATCTGCCTGACACAGAAGACCAAGAAACTGTGGACATTAATTCAGTCAGTGAAGGA
AAAGAGAATAATATAATGATAACCTTAGAAACAAATATTGAACATAATCTAAAATCTGAGGAAGAAAAGGATCAGGAAAAGCAACAGATG
TTTGAAAATAAGCTTATAAAATCTGAAGAAATTAAAGATACTATTTTGCAAACAGTAGATTTAGTTTCTCAAGAGACTGGAGAAAAAGAG
GCAAATATTCAGGCAGTTGATAGTGAAGTTGGGCTTACAAAGGAAGACACCCAAGAGAAATTGGGGGAAGACGACAAAACTCAAAAAGAT
GTGATCAGCAATACAAGTGATGTGATAGGAACATGTGAGGCAGCAGATGTGGCTCAGAAAGTGGATGAAGACAGTGCTGAGGATACGCAG
AGTAATGATGGGAAAGAAGTGGTCGAAGTAGGCCAGAAATTAATTAATAAGCCCATGGTGGGTCCTGAGGCTGGTGGTACTAAGGAAGTT
CCTATTAAAGAAATAGTTGAAATGAATGAAATAGAAGAAGGTAAAAATAAGGAACAAGCAATAAACAGTTCAGAGAACATAATGGACATC
AATGAGGAACCAGGAACAACTGAAGGTGAAGAAATCACTGAGTCAAGTAGCACTGAAGAAATGGAGGTCAGAAGTGTGGTGGCTGATACT
GACCAAAAGGCTTTAGGAAGTGAAGTTCAGGATGCTTCTAAAGTCACTACTCAGATAGATAAAGAGAAAAAAGAAATTCCAGTGTCAATT
AAAAAAGAGCCTGAAGTTACTGTAGTTTCACAGCCCACTGAACCTCAGCCTGTTCTAATACCCAGTATTAATATCAACTCTGACAGTGGA
GAAAATAAAGAAGAAATAGGTTCTTTATCAAAAACTGAAACTATTCTGCCACCAGAATCTGAGAATCCAAAGGAAAATGATAATGATTCA
GGCACTGGTTCCACTGCTGATACTAGCAGTATTGACTTGAATTTATCCATCTCTAGCTTTCTAAGTAAAACTAAAGACAGTGGATCGATA
TCTTTACAAGAAACAAGAAGACAAAAGAAAACATTGAAGAAAACACGCAAATTTATTGTTGATGGTGTAGAAGTGAGTGTAACAACATCA
AAGATAGTTACAGATAGTGATTCCAAAACTGAAGAATTGCGGTTTCTTAGACGTCAGGAACTTCGGGAATTAAGATTTCTTCAGAAAGAA
GAGCAAAGAGCCCAACAACAGCTCAATAGCAAACTACAGCAACAACGAGAACAAATTTTCCGGCGCTTTGAGCAGGAAATGATGAGTAAA
AAGCGACAATATGACCAGGAAATTGAGAATCTAGAAAAACAGCAGAAACAGACTATCGAACGCCTGGAACAAGAGCACACAAATCGCTTG
CGAGATGAAGCCAAACGCATCAAAGGAGAACAAGAGAAAGAGTTGTCCAAATTTCAGAATATGCTGAAGAACCGAAAGAAGGAGGTTATA
AATGAAGTGGAGAAAGCACCCAAAGAGCTGAGAAAAGAGCTCATGAAACGCAGGAAAGAGGAGCTTGCACAAAGCCAGCATGCTCAGGAA
CAAGAGTTTGTTCAGAAACAACAGCAAGAATTAGATGGCTCTCTGAAAAAGATCATCCAGCAGCAGAAGGCAGAGTTAGCTAATATTGAG
AGAGAGTGCCTGAATAACAAGCAACAGCTCATGAGAGCTCGAGAAGCTGCAATTTGGGAGCTCGAAGAACGACACTTACAAGAAAAACAC
CAGCTGCTCAAACAGCAGCTTAAAGATCAGTATTTCATGCAAAGACATCAGCTACTTAAGCGCCACGAGAAGGAAACAGAGCAAATGCAG
CGTTACAATCAAAGACTTATTGAGGAATTGAAAAACAGACAGACTCAAGAAAGAGCAAGACTGCCCAAGATTCAGCGCAGTGAAGCCAAG
ACTCGAATGGCCATGTTTAAGAAGAGTTTGAGAATTAACTCAACAGCCACACCAGATCAGGACCGTGATAAAATTAAACAGTTTGCTGCA
CAAGAAGAAAAGAGGCAGAAAAATGAGAGAATGGCTCAGCATCAGAAACATGAGAATCAAATGCGAGATCTTCAGTTGCAGTGTGAAGCC
AATGTCCGCGAACTGCATCAGCTGCAGAATGAAAAATGCCACTTGTTGGTTGAGCATGAGACTCAGAAACTGAAGGAGTTAGATGAGGAA
CATAGCCAAGAATTAAAGGAGTGGAGAGAGAAATTGAGACCTAGGAAAAAGACACTGGAAGAAGAGTTTGCCAGGAAACTACAGGAACAG
GAAGTATTCTTTAAAATGACTGGGGAGTCTGAATGCCTTAACCCATCAACACAGAGCCGGATTTCCAAATTTTATCCTATTCCCAGCTTG
CATTCCACCGGATCATAACAAAGGGAAGCATTCTGTGCGTGGGTTTGGCTCTTTCAGTATGTCATTCTGTTCTCATCTTCTGCCACAGTC
TCTCAGATAGCTCATGAAGACAATCACCTGCCTCACCTTCTAGGTGTTTTCCTTTTTTGTTTTTTTTGTTTTGTTTTGTTTTTAAGCAAA
GATGAAGGGAAAACGAACTAAGACAGACGCTAGGCCATGTTGGCAAAGTAGCATCTTGGTGACTAAGGTGACTTTGTATATTCATCTTAA
AAATTATGTTCTTTAGACACTGCTACCTGAAAACTGTTGGAGAAATAATGTTTAAAGTTATTTAAGAAAAACTGTTACATCACTAAGTAT
TAATAAATTCTTCTTACCTGACGTAACTTCTCAATGCCTAAATTCTGTAGTTGAAGCTCTGCTGCAGAGAGTTGGGATAATTTTCTTTTG
GTGGATCAGCTCTCATAAAAAAGCTATGATTTGCTCAAATATGCTGTTGACTCAGTAAATGAATATATTTTTTTCTTTAAATAGGAACAA
CCTCTTTTAAAAGAGAAAAATTATTTCAGTGATTTGTCAAAACGAATTACCTCTTTTGGCATGAGCTAATAATTGAGGGTGCTAATTTTC
TTAAGATAGTGCCTAAAACACTAAATTTCAGTCAAGTCGTAAGTAGGATTTTCTTTTTGATCAACAGGGACAAAAACATCTTTAGAATTA
AAAACATGGTTGTTTTGGAATTTTTGCTTCTCTTACCGTTTGATAGAAATTTTCATCCTAAAATACATGTACAAAGTTTGGAAAGATGAA
AAAAAGAGGTAGCTTTTAGATTGCAAACTGGAAATGTAAAACTCATGAAATTTAAGCAATATAGGTTTAGCTATCTGTGTTTATTTTCTA
AAATAATACCTGAGCTGGTTAAATGATTTCTCTCCATCTTAGCTAATTCTGTTTAAAACTCTGTCAGAGGCCTGCAGGCTGTGAGTTATA
TTTATAAATATATCTTCAGAAATTAATCTTAAAAGAGGCATTAGTTCAGAATACTTTTTTAAAAGTTTAAATTAAATATTTAGGCACGTC
AGGAATTACTTTTCCTTATTTTGAAATGAGGCTACTTATGTCTTGGTTTTATTTTGTTCCATGTTTAAATCATTCACTTTGATTTGAGTG
GGAAAAGCCTGAAGCCTTTATCATGTGGTTGCTGGTGTGTGTAATTATTAATGAAATGTTCACTCCTAGTCCCTTATGAGGCTTAGAATT
TCAACCACGTGTCAGGTCAGACAGTATTATAAACTGTACTTTGCTGTCTGAGACAGCACATTTGTGAATGATGCTTGCTGCCTGCCATTT
TCAACCTATTCTCTCTTAAGAGTGCTAGGTACCAAATTGTGAAAGTTTGTTTTCAGTTATATTACTTTTGAGGCTGGTGAAAAATTTAAA
TGTAACTTTGTGGGAACACTGATTCATATTTAGAAAATGTAAATGTCTGTAGCACTTTCTTGCAGTTAATTTGAAAACTTTGGATGCTGA
ACCTTGTTTGTCAGTGATTTAGATGATTTAAAAATGCATGTGTGATTTGAATTTTATAATTGTTTTGACAAGCATAATTTACTTGGACAA
CTTCGTAGGTAGCCTTAACTTCTGGCCAAGTTTGTTTTTTATATAAATATATATACATATATACATATTATGTATGGTTGTAAATTCATA
CACTTATCACATGAATGTGTTACTGTATACAAAACTCTTAATGCTTTATTCTCAAATGCTGGGTTGAAAAATGTTTTGAAAGCCTTTTAA
AATATATATCTTTATAAAGTAATATTCAGGATGATGATAAAAATTGTTTATATTGTTATGATAAAAATGACAGTATAATGTTGCCCAGTG
TATTTAATGATTTATTTGAAGAGGGATTGGGAAGGAACGTCTTCATACCACTTTCTCCTTTGAAATTTTCAGTTTATTGACTTTTAAAAA
ATGAATACCTCAGGCAGTAGACATTTTTTTTCTAGTATCATTTAATTGATACCCTGTGCGCTAAATAGTGTGTGGTGCCTGATTAATTTG
GTCTGAATATTTGATTCTTTCTGTTCCTTTCAACTTGACATTCAGATTATTGACTCAAGGAGAGAGGCTCAGAGTGGAATGGTTGGCGCT
GTGGGTAAGGTTGGATCTCCCTTAAAACTGCCTTTTGGATTCAGTGTTTGTGCTTGAGTTCGCTTTCAAATATGACCATAATCGTGTGGG
TGCAAGACTGTACAGTGATACATATGTAGAGGTAAAGCATTCATTTTAATACTTAAAGTTATATAAATCTTTTCAAAAAGTGTTTTGTTA
TAAAATACGCTGTTTGTACCCATACCAGCCCACCTCTTCTGAGGCCCTGTATTCAAATAGATGATAGTGATCTATCTTTCCTGCATGAAG
TGTAGGTGGCGAGTGGGCGAGGGGCGCAGACTTCTTTGAAATCGAAGGGTACAGTCAAATCTACTGCTGATTTGGTTGTTTTGTTGCTGT
GGCAGAATATGCCATGAAACACATACAGACTTCTCCGAACGTGCACCCTCATCAGCCACCTCCTCCCCTCTTTCCCTGAGTGCTGTGAAC
ACAGCAGACCTGCACACTTCTGCAGATCCAGCTCCTACAGCTTGGGGCACTAGGCTGCCTTTCCTAGTCCTGTCAACAACCATACAGTGC
GAATTGCTGAATTAGCTGCTATTCTATGTGGAGTCACATTAAGCTTTTTCTTATCTTTTTCTATGGGGAAGCTATAGGGTGGGTAAGGAA
AAAATGTTGAATGCTTTTACTTTGCTGAAAATATTAGAACTCTCTTGTGACAGGATACAGCAAATTATAATTAAATATAAATTACCAGAA
CCAGAGCTACCTCTAAGTCATACTTCCTCAAGCACAAAGCTCTCAGGCATATGAGACCCACCTTAATGAAGGGTCTCTGATTTCTTGAGC
ATCAGCGAGTTTCAGAAGTGACTATTTTTTTGTACTCTTCTAGTTTCCTTGTAACTATACACTTTTTCCCATTCCACACTGTGCTTAAAT
GACAAAGACTCTTCTGAGAAGCCAAATTCTGTCCAAGTATTAACTAGAGATATTGTTGATTAAAGAAAATCTAGAACTGAAGTGAAAGAA
GAGAGTTCCAGTTCTAATAGTCTTTTGATTAACAATTCTTTTCTGAGAAATGATTTTTATAAGAAATGGGGTGATTCTTTAAATGCTTTT
CTTAAGTTGAAGGCACAACAGTTAATGGCTGTATTGTTGCTATTCCGTTGCTGACATGTTTTTGATAAAGCTTTAACATTCCTGCTACTA
ATTTTGGCGGAGAGTGTTTGCCAGGTTTCAATGTGGGCTGCAGCTTTTTGTGCTCCTTCTCTGGTTTGCAGTGTAATGAGTTCATAAGCT
AAATTTTCAGAAAGAATTTTGTTTAAGATTATGCCTCTTATCTACTTGAGAGCAACATGTCTTTTCAATCATGGGATTGACACATGAAAA

>90646_90646_2_THEMIS-SLK_THEMIS_chr6_128221986_ENST00000368248_SLK_chr10_105750432_ENST00000369755_length(amino acids)=1187AA_BP=2
MKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQ
TLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEM
AEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDG
KEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEA
MTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQT
VDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKP
MVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQ
IDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSIS
SFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQ
IFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRR
KEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQL
LKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHE
NQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQ

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>90646_90646_3_THEMIS-SLK_THEMIS_chr6_128221986_ENST00000543064_SLK_chr10_105750432_ENST00000335753_length(transcript)=7218nt_BP=240nt
AGCTACTCCACCCCACTCTGGCTGTAGTGTGACATTCCTGCCTGCCTGAGGAAGAAATGGTGAGCAGGGGCTGCAATTGCAGACAAGTGT
CACCCAGAAGCCACAAGTTTCTGTGAGCACCAGGTCTACAAACTACCCAAGGCATAGCAATGGCATTATCACTGGAAGAATTCGTCCACT
CCCTTGACCTCAGGACCCTACCCAGGGTTCTAGAAATCCAGGCAGGCATCTATCTTGAAGGCCCAGAATAAAGAGACCAGTGTTTTAGCT
GCTGCAAAAGTGATTGACACTAAATCTGAAGAAGAACTTGAAGATTACATGGTAGAGATTGACATATTAGCATCTTGTGATCACCCAAAT
ATAGTCAAGCTTCTAGATGCCTTCTATTATGAGAACAATCTTTGGATCCTCATTGAATTTTGTGCAGGTGGAGCAGTAGATGCTGTGATG
CTTGAACTTGAGAGACCATTAACTGAGTCCCAAATACAAGTAGTTTGCAAGCAGACTTTAGATGCATTGAACTACTTACATGATAATAAG
ATCATCCACAGAGATCTGAAGGCTGGCAACATTCTCTTTACCTTAGATGGAGATATCAAATTGGCGGATTTTGGAGTATCAGCTAAAAAC
ACGAGGACAATTCAAAGAAGAGATTCCTTTATTGGTACACCATATTGGATGGCTCCTGAAGTAGTCATGTGTGAAACATCTAAGGACAGA
CCCTATGACTACAAAGCTGATGTTTGGTCCCTGGGTATCACTTTAATAGAAATGGCTGAGATAGAACCACCTCATCATGAATTAAATCCA
ATGCGAGTGCTGCTAAAAATAGCAAAATCTGAGCCACCTACATTAGCACAGCCATCCAGATGGTCTTCAAATTTTAAGGACTTTCTAAAG
AAATGCTTAGAAAAGAATGTGGATGCCAGGTGGACTACATCTCAGCTGCTGCAGCATCCCTTTGTTACTGTTGATTCCAACAAACCCATC
CGAGAATTGATTGCAGAGGCGAAGGCTGAAGTAACAGAAGAAGTTGAAGATGGCAAAGAGGAAGATGAAGAGGAGGAAACAGAAAATTCT
CTGCCAATACCTGCAAGTAAGCGTGCATCTTCTGACCTTAGTATCGCCAGCTCTGAAGAAGATAAACTTTCACAAAATGCTTGTATTTTG
GAGTCTGTCTCAGAAAAAACAGAACGTAGTAACTCTGAAGATAAACTCAACAGCAAAATTCTTAATGAAAAACCCACCACTGATGAACCT
GAAAAGGCTGTGGAGGATATTAATGAACATATTACCGATGCTCAGTTAGAAGCAATGACTGAACTCCATGACAGAACAGCAGTAATCAAG
GAGAATGAAAGAGAGAAGAGGCCCAAGCTTGAAAATCTGCCTGACACAGAAGACCAAGAAACTGTGGACATTAATTCAGTCAGTGAAGGA
AAAGAGAATAATATAATGATAACCTTAGAAACAAATATTGAACATAATCTAAAATCTGAGGAAGAAAAGGATCAGGAAAAGCAACAGATG
TTTGAAAATAAGCTTATAAAATCTGAAGAAATTAAAGATACTATTTTGCAAACAGTAGATTTAGTTTCTCAAGAGACTGGAGAAAAAGAG
GCAAATATTCAGGCAGTTGATAGTGAAGTTGGGCTTACAAAGGAAGACACCCAAGAGAAATTGGGGGAAGACGACAAAACTCAAAAAGAT
GTGATCAGCAATACAAGTGATGTGATAGGAACATGTGAGGCAGCAGATGTGGCTCAGAAAGTGGATGAAGACAGTGCTGAGGATACGCAG
AGTAATGATGGGAAAGAAGTGGTCGAAGTAGGCCAGAAATTAATTAATAAGCCCATGGTGGGTCCTGAGGCTGGTGGTACTAAGGAAGTT
CCTATTAAAGAAATAGTTGAAATGAATGAAATAGAAGAAGGTAAAAATAAGGAACAAGCAATAAACAGTTCAGAGAACATAATGGACATC
AATGAGGAACCAGGAACAACTGAAGGTGAAGAAATCACTGAGTCAAGTAGCACTGAAGAAATGGAGGTCAGAAGTGTGGTGGCTGATACT
GACCAAAAGGCTTTAGGAAGTGAAGTTCAGGATGCTTCTAAAGTCACTACTCAGATAGATAAAGAGAAAAAAGAAATTCCAGTGTCAATT
AAAAAAGAGCCTGAAGTTACTGTAGTTTCACAGCCCACTGAACCTCAGCCTGTTCTAATACCCAGTATTAATATCAACTCTGACAGTGGA
GAAAATAAAGAAGAAATAGGTTCTTTATCAAAAACTGAAACTATTCTGCCACCAGAATCTGAGAATCCAAAGGAAAATGATAATGATTCA
GGCACTGGTTCCACTGCTGATACTAGCAGTATTGACTTGAATTTATCCATCTCTAGCTTTCTAAGTAAAACTAAAGACAGTGGATCGATA
TCTTTACAAGAAACAAGAAGACAAAAGAAAACATTGAAGAAAACACGCAAATTTATTGTTGATGGTGTAGAAGTGAGTGTAACAACATCA
AAGATAGTTACAGATAGTGATTCCAAAACTGAAGAATTGCGGTTTCTTAGACGTCAGGAACTTCGGGAATTAAGATTTCTTCAGAAAGAA
GAGCAAAGAGCCCAACAACAGCTCAATAGCAAACTACAGCAACAACGAGAACAAATTTTCCGGCGCTTTGAGCAGGAAATGATGAGTAAA
AAGCGACAATATGACCAGGAAATTGAGAATCTAGAAAAACAGCAGAAACAGACTATCGAACGCCTGGAACAAGAGCACACAAATCGCTTG
CGAGATGAAGCCAAACGCATCAAAGGAGAACAAGAGAAAGAGTTGTCCAAATTTCAGAATATGCTGAAGAACCGAAAGAAGGAGGAACAA
GAGTTTGTTCAGAAACAACAGCAAGAATTAGATGGCTCTCTGAAAAAGATCATCCAGCAGCAGAAGGCAGAGTTAGCTAATATTGAGAGA
GAGTGCCTGAATAACAAGCAACAGCTCATGAGAGCTCGAGAAGCTGCAATTTGGGAGCTCGAAGAACGACACTTACAAGAAAAACACCAG
CTGCTCAAACAGCAGCTTAAAGATCAGTATTTCATGCAAAGACATCAGCTACTTAAGCGCCACGAGAAGGAAACAGAGCAAATGCAGCGT
TACAATCAAAGACTTATTGAGGAATTGAAAAACAGACAGACTCAAGAAAGAGCAAGACTGCCCAAGATTCAGCGCAGTGAAGCCAAGACT
CGAATGGCCATGTTTAAGAAGAGTTTGAGAATTAACTCAACAGCCACACCAGATCAGGACCGTGATAAAATTAAACAGTTTGCTGCACAA
GAAGAAAAGAGGCAGAAAAATGAGAGAATGGCTCAGCATCAGAAACATGAGAATCAAATGCGAGATCTTCAGTTGCAGTGTGAAGCCAAT
GTCCGCGAACTGCATCAGCTGCAGAATGAAAAATGCCACTTGTTGGTTGAGCATGAGACTCAGAAACTGAAGGAGTTAGATGAGGAACAT
AGCCAAGAATTAAAGGAGTGGAGAGAGAAATTGAGACCTAGGAAAAAGACACTGGAAGAAGAGTTTGCCAGGAAACTACAGGAACAGGAA
GTATTCTTTAAAATGACTGGGGAGTCTGAATGCCTTAACCCATCAACACAGAGCCGGATTTCCAAATTTTATCCTATTCCCAGCTTGCAT
TCCACCGGATCATAACAAAGGGAAGCATTCTGTGCGTGGGTTTGGCTCTTTCAGTATGTCATTCTGTTCTCATCTTCTGCCACAGTCTCT
CAGATAGCTCATGAAGACAATCACCTGCCTCACCTTCTAGGTGTTTTCCTTTTTTGTTTTTTTTGTTTTGTTTTGTTTTTAAGCAAAGAT
GAAGGGAAAACGAACTAAGACAGACGCTAGGCCATGTTGGCAAAGTAGCATCTTGGTGACTAAGGTGACTTTGTATATTCATCTTAAAAA
TTATGTTCTTTAGACACTGCTACCTGAAAACTGTTGGAGAAATAATGTTTAAAGTTATTTAAGAAAAACTGTTACATCACTAAGTATTAA
TAAATTCTTCTTACCTGACGTAACTTCTCAATGCCTAAATTCTGTAGTTGAAGCTCTGCTGCAGAGAGTTGGGATAATTTTCTTTTGGTG
GATCAGCTCTCATAAAAAAGCTATGATTTGCTCAAATATGCTGTTGACTCAGTAAATGAATATATTTTTTTCTTTAAATAGGAACAACCT
CTTTTAAAAGAGAAAAATTATTTCAGTGATTTGTCAAAACGAATTACCTCTTTTGGCATGAGCTAATAATTGAGGGTGCTAATTTTCTTA
AGATAGTGCCTAAAACACTAAATTTCAGTCAAGTCGTAAGTAGGATTTTCTTTTTGATCAACAGGGACAAAAACATCTTTAGAATTAAAA
ACATGGTTGTTTTGGAATTTTTGCTTCTCTTACCGTTTGATAGAAATTTTCATCCTAAAATACATGTACAAAGTTTGGAAAGATGAAAAA
AAGAGGTAGCTTTTAGATTGCAAACTGGAAATGTAAAACTCATGAAATTTAAGCAATATAGGTTTAGCTATCTGTGTTTATTTTCTAAAA
TAATACCTGAGCTGGTTAAATGATTTCTCTCCATCTTAGCTAATTCTGTTTAAAACTCTGTCAGAGGCCTGCAGGCTGTGAGTTATATTT
ATAAATATATCTTCAGAAATTAATCTTAAAAGAGGCATTAGTTCAGAATACTTTTTTAAAAGTTTAAATTAAATATTTAGGCACGTCAGG
AATTACTTTTCCTTATTTTGAAATGAGGCTACTTATGTCTTGGTTTTATTTTGTTCCATGTTTAAATCATTCACTTTGATTTGAGTGGGA
AAAGCCTGAAGCCTTTATCATGTGGTTGCTGGTGTGTGTAATTATTAATGAAATGTTCACTCCTAGTCCCTTATGAGGCTTAGAATTTCA
ACCACGTGTCAGGTCAGACAGTATTATAAACTGTACTTTGCTGTCTGAGACAGCACATTTGTGAATGATGCTTGCTGCCTGCCATTTTCA
ACCTATTCTCTCTTAAGAGTGCTAGGTACCAAATTGTGAAAGTTTGTTTTCAGTTATATTACTTTTGAGGCTGGTGAAAAATTTAAATGT
AACTTTGTGGGAACACTGATTCATATTTAGAAAATGTAAATGTCTGTAGCACTTTCTTGCAGTTAATTTGAAAACTTTGGATGCTGAACC
TTGTTTGTCAGTGATTTAGATGATTTAAAAATGCATGTGTGATTTGAATTTTATAATTGTTTTGACAAGCATAATTTACTTGGACAACTT
CGTAGGTAGCCTTAACTTCTGGCCAAGTTTGTTTTTTATATAAATATATATACATATATACATATTATGTATGGTTGTAAATTCATACAC
TTATCACATGAATGTGTTACTGTATACAAAACTCTTAATGCTTTATTCTCAAATGCTGGGTTGAAAAATGTTTTGAAAGCCTTTTAAAAT
ATATATCTTTATAAAGTAATATTCAGGATGATGATAAAAATTGTTTATATTGTTATGATAAAAATGACAGTATAATGTTGCCCAGTGTAT
TTAATGATTTATTTGAAGAGGGATTGGGAAGGAACGTCTTCATACCACTTTCTCCTTTGAAATTTTCAGTTTATTGACTTTTAAAAAATG
AATACCTCAGGCAGTAGACATTTTTTTTCTAGTATCATTTAATTGATACCCTGTGCGCTAAATAGTGTGTGGTGCCTGATTAATTTGGTC
TGAATATTTGATTCTTTCTGTTCCTTTCAACTTGACATTCAGATTATTGACTCAAGGAGAGAGGCTCAGAGTGGAATGGTTGGCGCTGTG
GGTAAGGTTGGATCTCCCTTAAAACTGCCTTTTGGATTCAGTGTTTGTGCTTGAGTTCGCTTTCAAATATGACCATAATCGTGTGGGTGC
AAGACTGTACAGTGATACATATGTAGAGGTAAAGCATTCATTTTAATACTTAAAGTTATATAAATCTTTTCAAAAAGTGTTTTGTTATAA
AATACGCTGTTTGTACCCATACCAGCCCACCTCTTCTGAGGCCCTGTATTCAAATAGATGATAGTGATCTATCTTTCCTGCATGAAGTGT
AGGTGGCGAGTGGGCGAGGGGCGCAGACTTCTTTGAAATCGAAGGGTACAGTCAAATCTACTGCTGATTTGGTTGTTTTGTTGCTGTGGC
AGAATATGCCATGAAACACATACAGACTTCTCCGAACGTGCACCCTCATCAGCCACCTCCTCCCCTCTTTCCCTGAGTGCTGTGAACACA
GCAGACCTGCACACTTCTGCAGATCCAGCTCCTACAGCTTGGGGCACTAGGCTGCCTTTCCTAGTCCTGTCAACAACCATACAGTGCGAA
TTGCTGAATTAGCTGCTATTCTATGTGGAGTCACATTAAGCTTTTTCTTATCTTTTTCTATGGGGAAGCTATAGGGTGGGTAAGGAAAAA
ATGTTGAATGCTTTTACTTTGCTGAAAATATTAGAACTCTCTTGTGACAGGATACAGCAAATTATAATTAAATATAAATTACCAGAACCA
GAGCTACCTCTAAGTCATACTTCCTCAAGCACAAAGCTCTCAGGCATATGAGACCCACCTTAATGAAGGGTCTCTGATTTCTTGAGCATC
AGCGAGTTTCAGAAGTGACTATTTTTTTGTACTCTTCTAGTTTCCTTGTAACTATACACTTTTTCCCATTCCACACTGTGCTTAAATGAC
AAAGACTCTTCTGAGAAGCCAAATTCTGTCCAAGTATTAACTAGAGATATTGTTGATTAAAGAAAATCTAGAACTGAAGTGAAAGAAGAG
AGTTCCAGTTCTAATAGTCTTTTGATTAACAATTCTTTTCTGAGAAATGATTTTTATAAGAAATGGGGTGATTCTTTAAATGCTTTTCTT
AAGTTGAAGGCACAACAGTTAATGGCTGTATTGTTGCTATTCCGTTGCTGACATGTTTTTGATAAAGCTTTAACATTCCTGCTACTAATT
TTGGCGGAGAGTGTTTGCCAGGTTTCAATGTGGGCTGCAGCTTTTTGTGCTCCTTCTCTGGTTTGCAGTGTAATGAGTTCATAAGCTAAA
TTTTCAGAAAGAATTTTGTTTAAGATTATGCCTCTTATCTACTTGAGAGCAACATGTCTTTTCAATCATGGGATTGACACATGAAAAATA

>90646_90646_3_THEMIS-SLK_THEMIS_chr6_128221986_ENST00000543064_SLK_chr10_105750432_ENST00000335753_length(amino acids)=1156AA_BP=2
MKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQ
TLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEM
AEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDG
KEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEA
MTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQT
VDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKP
MVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQ
IDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSIS
SFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQ
IFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEEQEFVQKQQQELDGSLKKII
QQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERA
RLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEH

--------------------------------------------------------------
>90646_90646_4_THEMIS-SLK_THEMIS_chr6_128221986_ENST00000543064_SLK_chr10_105750432_ENST00000369755_length(transcript)=7311nt_BP=240nt
AGCTACTCCACCCCACTCTGGCTGTAGTGTGACATTCCTGCCTGCCTGAGGAAGAAATGGTGAGCAGGGGCTGCAATTGCAGACAAGTGT
CACCCAGAAGCCACAAGTTTCTGTGAGCACCAGGTCTACAAACTACCCAAGGCATAGCAATGGCATTATCACTGGAAGAATTCGTCCACT
CCCTTGACCTCAGGACCCTACCCAGGGTTCTAGAAATCCAGGCAGGCATCTATCTTGAAGGCCCAGAATAAAGAGACCAGTGTTTTAGCT
GCTGCAAAAGTGATTGACACTAAATCTGAAGAAGAACTTGAAGATTACATGGTAGAGATTGACATATTAGCATCTTGTGATCACCCAAAT
ATAGTCAAGCTTCTAGATGCCTTCTATTATGAGAACAATCTTTGGATCCTCATTGAATTTTGTGCAGGTGGAGCAGTAGATGCTGTGATG
CTTGAACTTGAGAGACCATTAACTGAGTCCCAAATACAAGTAGTTTGCAAGCAGACTTTAGATGCATTGAACTACTTACATGATAATAAG
ATCATCCACAGAGATCTGAAGGCTGGCAACATTCTCTTTACCTTAGATGGAGATATCAAATTGGCGGATTTTGGAGTATCAGCTAAAAAC
ACGAGGACAATTCAAAGAAGAGATTCCTTTATTGGTACACCATATTGGATGGCTCCTGAAGTAGTCATGTGTGAAACATCTAAGGACAGA
CCCTATGACTACAAAGCTGATGTTTGGTCCCTGGGTATCACTTTAATAGAAATGGCTGAGATAGAACCACCTCATCATGAATTAAATCCA
ATGCGAGTGCTGCTAAAAATAGCAAAATCTGAGCCACCTACATTAGCACAGCCATCCAGATGGTCTTCAAATTTTAAGGACTTTCTAAAG
AAATGCTTAGAAAAGAATGTGGATGCCAGGTGGACTACATCTCAGCTGCTGCAGCATCCCTTTGTTACTGTTGATTCCAACAAACCCATC
CGAGAATTGATTGCAGAGGCGAAGGCTGAAGTAACAGAAGAAGTTGAAGATGGCAAAGAGGAAGATGAAGAGGAGGAAACAGAAAATTCT
CTGCCAATACCTGCAAGTAAGCGTGCATCTTCTGACCTTAGTATCGCCAGCTCTGAAGAAGATAAACTTTCACAAAATGCTTGTATTTTG
GAGTCTGTCTCAGAAAAAACAGAACGTAGTAACTCTGAAGATAAACTCAACAGCAAAATTCTTAATGAAAAACCCACCACTGATGAACCT
GAAAAGGCTGTGGAGGATATTAATGAACATATTACCGATGCTCAGTTAGAAGCAATGACTGAACTCCATGACAGAACAGCAGTAATCAAG
GAGAATGAAAGAGAGAAGAGGCCCAAGCTTGAAAATCTGCCTGACACAGAAGACCAAGAAACTGTGGACATTAATTCAGTCAGTGAAGGA
AAAGAGAATAATATAATGATAACCTTAGAAACAAATATTGAACATAATCTAAAATCTGAGGAAGAAAAGGATCAGGAAAAGCAACAGATG
TTTGAAAATAAGCTTATAAAATCTGAAGAAATTAAAGATACTATTTTGCAAACAGTAGATTTAGTTTCTCAAGAGACTGGAGAAAAAGAG
GCAAATATTCAGGCAGTTGATAGTGAAGTTGGGCTTACAAAGGAAGACACCCAAGAGAAATTGGGGGAAGACGACAAAACTCAAAAAGAT
GTGATCAGCAATACAAGTGATGTGATAGGAACATGTGAGGCAGCAGATGTGGCTCAGAAAGTGGATGAAGACAGTGCTGAGGATACGCAG
AGTAATGATGGGAAAGAAGTGGTCGAAGTAGGCCAGAAATTAATTAATAAGCCCATGGTGGGTCCTGAGGCTGGTGGTACTAAGGAAGTT
CCTATTAAAGAAATAGTTGAAATGAATGAAATAGAAGAAGGTAAAAATAAGGAACAAGCAATAAACAGTTCAGAGAACATAATGGACATC
AATGAGGAACCAGGAACAACTGAAGGTGAAGAAATCACTGAGTCAAGTAGCACTGAAGAAATGGAGGTCAGAAGTGTGGTGGCTGATACT
GACCAAAAGGCTTTAGGAAGTGAAGTTCAGGATGCTTCTAAAGTCACTACTCAGATAGATAAAGAGAAAAAAGAAATTCCAGTGTCAATT
AAAAAAGAGCCTGAAGTTACTGTAGTTTCACAGCCCACTGAACCTCAGCCTGTTCTAATACCCAGTATTAATATCAACTCTGACAGTGGA
GAAAATAAAGAAGAAATAGGTTCTTTATCAAAAACTGAAACTATTCTGCCACCAGAATCTGAGAATCCAAAGGAAAATGATAATGATTCA
GGCACTGGTTCCACTGCTGATACTAGCAGTATTGACTTGAATTTATCCATCTCTAGCTTTCTAAGTAAAACTAAAGACAGTGGATCGATA
TCTTTACAAGAAACAAGAAGACAAAAGAAAACATTGAAGAAAACACGCAAATTTATTGTTGATGGTGTAGAAGTGAGTGTAACAACATCA
AAGATAGTTACAGATAGTGATTCCAAAACTGAAGAATTGCGGTTTCTTAGACGTCAGGAACTTCGGGAATTAAGATTTCTTCAGAAAGAA
GAGCAAAGAGCCCAACAACAGCTCAATAGCAAACTACAGCAACAACGAGAACAAATTTTCCGGCGCTTTGAGCAGGAAATGATGAGTAAA
AAGCGACAATATGACCAGGAAATTGAGAATCTAGAAAAACAGCAGAAACAGACTATCGAACGCCTGGAACAAGAGCACACAAATCGCTTG
CGAGATGAAGCCAAACGCATCAAAGGAGAACAAGAGAAAGAGTTGTCCAAATTTCAGAATATGCTGAAGAACCGAAAGAAGGAGGTTATA
AATGAAGTGGAGAAAGCACCCAAAGAGCTGAGAAAAGAGCTCATGAAACGCAGGAAAGAGGAGCTTGCACAAAGCCAGCATGCTCAGGAA
CAAGAGTTTGTTCAGAAACAACAGCAAGAATTAGATGGCTCTCTGAAAAAGATCATCCAGCAGCAGAAGGCAGAGTTAGCTAATATTGAG
AGAGAGTGCCTGAATAACAAGCAACAGCTCATGAGAGCTCGAGAAGCTGCAATTTGGGAGCTCGAAGAACGACACTTACAAGAAAAACAC
CAGCTGCTCAAACAGCAGCTTAAAGATCAGTATTTCATGCAAAGACATCAGCTACTTAAGCGCCACGAGAAGGAAACAGAGCAAATGCAG
CGTTACAATCAAAGACTTATTGAGGAATTGAAAAACAGACAGACTCAAGAAAGAGCAAGACTGCCCAAGATTCAGCGCAGTGAAGCCAAG
ACTCGAATGGCCATGTTTAAGAAGAGTTTGAGAATTAACTCAACAGCCACACCAGATCAGGACCGTGATAAAATTAAACAGTTTGCTGCA
CAAGAAGAAAAGAGGCAGAAAAATGAGAGAATGGCTCAGCATCAGAAACATGAGAATCAAATGCGAGATCTTCAGTTGCAGTGTGAAGCC
AATGTCCGCGAACTGCATCAGCTGCAGAATGAAAAATGCCACTTGTTGGTTGAGCATGAGACTCAGAAACTGAAGGAGTTAGATGAGGAA
CATAGCCAAGAATTAAAGGAGTGGAGAGAGAAATTGAGACCTAGGAAAAAGACACTGGAAGAAGAGTTTGCCAGGAAACTACAGGAACAG
GAAGTATTCTTTAAAATGACTGGGGAGTCTGAATGCCTTAACCCATCAACACAGAGCCGGATTTCCAAATTTTATCCTATTCCCAGCTTG
CATTCCACCGGATCATAACAAAGGGAAGCATTCTGTGCGTGGGTTTGGCTCTTTCAGTATGTCATTCTGTTCTCATCTTCTGCCACAGTC
TCTCAGATAGCTCATGAAGACAATCACCTGCCTCACCTTCTAGGTGTTTTCCTTTTTTGTTTTTTTTGTTTTGTTTTGTTTTTAAGCAAA
GATGAAGGGAAAACGAACTAAGACAGACGCTAGGCCATGTTGGCAAAGTAGCATCTTGGTGACTAAGGTGACTTTGTATATTCATCTTAA
AAATTATGTTCTTTAGACACTGCTACCTGAAAACTGTTGGAGAAATAATGTTTAAAGTTATTTAAGAAAAACTGTTACATCACTAAGTAT
TAATAAATTCTTCTTACCTGACGTAACTTCTCAATGCCTAAATTCTGTAGTTGAAGCTCTGCTGCAGAGAGTTGGGATAATTTTCTTTTG
GTGGATCAGCTCTCATAAAAAAGCTATGATTTGCTCAAATATGCTGTTGACTCAGTAAATGAATATATTTTTTTCTTTAAATAGGAACAA
CCTCTTTTAAAAGAGAAAAATTATTTCAGTGATTTGTCAAAACGAATTACCTCTTTTGGCATGAGCTAATAATTGAGGGTGCTAATTTTC
TTAAGATAGTGCCTAAAACACTAAATTTCAGTCAAGTCGTAAGTAGGATTTTCTTTTTGATCAACAGGGACAAAAACATCTTTAGAATTA
AAAACATGGTTGTTTTGGAATTTTTGCTTCTCTTACCGTTTGATAGAAATTTTCATCCTAAAATACATGTACAAAGTTTGGAAAGATGAA
AAAAAGAGGTAGCTTTTAGATTGCAAACTGGAAATGTAAAACTCATGAAATTTAAGCAATATAGGTTTAGCTATCTGTGTTTATTTTCTA
AAATAATACCTGAGCTGGTTAAATGATTTCTCTCCATCTTAGCTAATTCTGTTTAAAACTCTGTCAGAGGCCTGCAGGCTGTGAGTTATA
TTTATAAATATATCTTCAGAAATTAATCTTAAAAGAGGCATTAGTTCAGAATACTTTTTTAAAAGTTTAAATTAAATATTTAGGCACGTC
AGGAATTACTTTTCCTTATTTTGAAATGAGGCTACTTATGTCTTGGTTTTATTTTGTTCCATGTTTAAATCATTCACTTTGATTTGAGTG
GGAAAAGCCTGAAGCCTTTATCATGTGGTTGCTGGTGTGTGTAATTATTAATGAAATGTTCACTCCTAGTCCCTTATGAGGCTTAGAATT
TCAACCACGTGTCAGGTCAGACAGTATTATAAACTGTACTTTGCTGTCTGAGACAGCACATTTGTGAATGATGCTTGCTGCCTGCCATTT
TCAACCTATTCTCTCTTAAGAGTGCTAGGTACCAAATTGTGAAAGTTTGTTTTCAGTTATATTACTTTTGAGGCTGGTGAAAAATTTAAA
TGTAACTTTGTGGGAACACTGATTCATATTTAGAAAATGTAAATGTCTGTAGCACTTTCTTGCAGTTAATTTGAAAACTTTGGATGCTGA
ACCTTGTTTGTCAGTGATTTAGATGATTTAAAAATGCATGTGTGATTTGAATTTTATAATTGTTTTGACAAGCATAATTTACTTGGACAA
CTTCGTAGGTAGCCTTAACTTCTGGCCAAGTTTGTTTTTTATATAAATATATATACATATATACATATTATGTATGGTTGTAAATTCATA
CACTTATCACATGAATGTGTTACTGTATACAAAACTCTTAATGCTTTATTCTCAAATGCTGGGTTGAAAAATGTTTTGAAAGCCTTTTAA
AATATATATCTTTATAAAGTAATATTCAGGATGATGATAAAAATTGTTTATATTGTTATGATAAAAATGACAGTATAATGTTGCCCAGTG
TATTTAATGATTTATTTGAAGAGGGATTGGGAAGGAACGTCTTCATACCACTTTCTCCTTTGAAATTTTCAGTTTATTGACTTTTAAAAA
ATGAATACCTCAGGCAGTAGACATTTTTTTTCTAGTATCATTTAATTGATACCCTGTGCGCTAAATAGTGTGTGGTGCCTGATTAATTTG
GTCTGAATATTTGATTCTTTCTGTTCCTTTCAACTTGACATTCAGATTATTGACTCAAGGAGAGAGGCTCAGAGTGGAATGGTTGGCGCT
GTGGGTAAGGTTGGATCTCCCTTAAAACTGCCTTTTGGATTCAGTGTTTGTGCTTGAGTTCGCTTTCAAATATGACCATAATCGTGTGGG
TGCAAGACTGTACAGTGATACATATGTAGAGGTAAAGCATTCATTTTAATACTTAAAGTTATATAAATCTTTTCAAAAAGTGTTTTGTTA
TAAAATACGCTGTTTGTACCCATACCAGCCCACCTCTTCTGAGGCCCTGTATTCAAATAGATGATAGTGATCTATCTTTCCTGCATGAAG
TGTAGGTGGCGAGTGGGCGAGGGGCGCAGACTTCTTTGAAATCGAAGGGTACAGTCAAATCTACTGCTGATTTGGTTGTTTTGTTGCTGT
GGCAGAATATGCCATGAAACACATACAGACTTCTCCGAACGTGCACCCTCATCAGCCACCTCCTCCCCTCTTTCCCTGAGTGCTGTGAAC
ACAGCAGACCTGCACACTTCTGCAGATCCAGCTCCTACAGCTTGGGGCACTAGGCTGCCTTTCCTAGTCCTGTCAACAACCATACAGTGC
GAATTGCTGAATTAGCTGCTATTCTATGTGGAGTCACATTAAGCTTTTTCTTATCTTTTTCTATGGGGAAGCTATAGGGTGGGTAAGGAA
AAAATGTTGAATGCTTTTACTTTGCTGAAAATATTAGAACTCTCTTGTGACAGGATACAGCAAATTATAATTAAATATAAATTACCAGAA
CCAGAGCTACCTCTAAGTCATACTTCCTCAAGCACAAAGCTCTCAGGCATATGAGACCCACCTTAATGAAGGGTCTCTGATTTCTTGAGC
ATCAGCGAGTTTCAGAAGTGACTATTTTTTTGTACTCTTCTAGTTTCCTTGTAACTATACACTTTTTCCCATTCCACACTGTGCTTAAAT
GACAAAGACTCTTCTGAGAAGCCAAATTCTGTCCAAGTATTAACTAGAGATATTGTTGATTAAAGAAAATCTAGAACTGAAGTGAAAGAA
GAGAGTTCCAGTTCTAATAGTCTTTTGATTAACAATTCTTTTCTGAGAAATGATTTTTATAAGAAATGGGGTGATTCTTTAAATGCTTTT
CTTAAGTTGAAGGCACAACAGTTAATGGCTGTATTGTTGCTATTCCGTTGCTGACATGTTTTTGATAAAGCTTTAACATTCCTGCTACTA
ATTTTGGCGGAGAGTGTTTGCCAGGTTTCAATGTGGGCTGCAGCTTTTTGTGCTCCTTCTCTGGTTTGCAGTGTAATGAGTTCATAAGCT
AAATTTTCAGAAAGAATTTTGTTTAAGATTATGCCTCTTATCTACTTGAGAGCAACATGTCTTTTCAATCATGGGATTGACACATGAAAA

>90646_90646_4_THEMIS-SLK_THEMIS_chr6_128221986_ENST00000543064_SLK_chr10_105750432_ENST00000369755_length(amino acids)=1187AA_BP=2
MKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQ
TLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEM
AEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDG
KEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEA
MTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQT
VDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKP
MVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQ
IDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSIS
SFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQ
IFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRR
KEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQL
LKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHE
NQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for THEMIS-SLK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THEMIS-SLK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THEMIS-SLK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource