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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THOC2-BRWD3 (FusionGDB2 ID:90658)

Fusion Gene Summary for THOC2-BRWD3

check button Fusion gene summary
Fusion gene informationFusion gene name: THOC2-BRWD3
Fusion gene ID: 90658
HgeneTgene
Gene symbol

THOC2

BRWD3

Gene ID

57187

254065

Gene nameTHO complex 2bromodomain and WD repeat domain containing 3
SynonymsCXorf3|MRX12|MRX35|THO2|dJ506G2.1|hTREX120BRODL|MRX93
Cytomap

Xq25

Xq21.1

Type of geneprotein-codingprotein-coding
DescriptionTHO complex subunit 2mental retardation, X-linked 12mental retardation, X-linked 35bromodomain and WD repeat-containing protein 3bromo domain-containing protein disrupted in leukemianovel WD repeat domain protein
Modification date2020032920200313
UniProtAcc.

Q6RI45

Ensembl transtripts involved in fusion geneENST00000245838, ENST00000355725, 
ENST00000491737, ENST00000497887, 
ENST00000373275, ENST00000473691, 
Fusion gene scores* DoF score7 X 7 X 4=1962 X 2 X 2=8
# samples 72
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: THOC2 [Title/Abstract] AND BRWD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHOC2(122744769)-BRWD3(80049271), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHOC2

GO:0006406

mRNA export from nucleus

17190602

HgeneTHOC2

GO:0016973

poly(A)+ mRNA export from nucleus

22928037

HgeneTHOC2

GO:0046784

viral mRNA export from host cell nucleus

18974867


check buttonFusion gene breakpoints across THOC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRWD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4IY-01ATHOC2chrX

122744769

-BRWD3chrX

80049271

-


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Fusion Gene ORF analysis for THOC2-BRWD3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000245838ENST00000373275THOC2chrX

122744769

-BRWD3chrX

80049271

-
3UTR-3CDSENST00000355725ENST00000373275THOC2chrX

122744769

-BRWD3chrX

80049271

-
3UTR-intronENST00000245838ENST00000473691THOC2chrX

122744769

-BRWD3chrX

80049271

-
3UTR-intronENST00000355725ENST00000473691THOC2chrX

122744769

-BRWD3chrX

80049271

-
5CDS-intronENST00000491737ENST00000473691THOC2chrX

122744769

-BRWD3chrX

80049271

-
5UTR-3CDSENST00000497887ENST00000373275THOC2chrX

122744769

-BRWD3chrX

80049271

-
5UTR-intronENST00000497887ENST00000473691THOC2chrX

122744769

-BRWD3chrX

80049271

-
In-frameENST00000491737ENST00000373275THOC2chrX

122744769

-BRWD3chrX

80049271

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000491737THOC2chrX122744769-ENST00000373275BRWD3chrX80049271-154364452458496801698

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000491737ENST00000373275THOC2chrX122744769-BRWD3chrX80049271-0.061767610.93823236

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Fusion Genomic Features for THOC2-BRWD3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THOC2-BRWD3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:122744769/chrX:80049271)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRWD3

Q6RI45

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHOC2chrX:122744769chrX:80049271ENST00000245838-38391464_149116001814.3333333333333Coiled coilOntology_term=ECO:0000255
HgeneTHOC2chrX:122744769chrX:80049271ENST00000245838-3839293_33916001814.3333333333333Coiled coilOntology_term=ECO:0000255
HgeneTHOC2chrX:122744769chrX:80049271ENST00000245838-3839896_96516001814.3333333333333Coiled coilOntology_term=ECO:0000255
HgeneTHOC2chrX:122744769chrX:80049271ENST00000355725-38391464_149116001586.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneTHOC2chrX:122744769chrX:80049271ENST00000355725-3839293_33916001586.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneTHOC2chrX:122744769chrX:80049271ENST00000355725-3839896_96516001586.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneTHOC2chrX:122744769chrX:80049271ENST00000491737-34341464_149114841479.0Coiled coilOntology_term=ECO:0000255
HgeneTHOC2chrX:122744769chrX:80049271ENST00000491737-3434293_33914841479.0Coiled coilOntology_term=ECO:0000255
HgeneTHOC2chrX:122744769chrX:80049271ENST00000491737-3434896_96514841479.0Coiled coilOntology_term=ECO:0000255
HgeneTHOC2chrX:122744769chrX:80049271ENST00000245838-38391264_159116001814.3333333333333Compositional biasNote=Lys-rich
HgeneTHOC2chrX:122744769chrX:80049271ENST00000355725-38391264_159116001586.6666666666667Compositional biasNote=Lys-rich
HgeneTHOC2chrX:122744769chrX:80049271ENST00000491737-34341264_159114841479.0Compositional biasNote=Lys-rich
HgeneTHOC2chrX:122744769chrX:80049271ENST00000245838-3839923_92816001814.3333333333333MotifNuclear localization signal
HgeneTHOC2chrX:122744769chrX:80049271ENST00000355725-3839923_92816001586.6666666666667MotifNuclear localization signal
HgeneTHOC2chrX:122744769chrX:80049271ENST00000491737-3434923_92814841479.0MotifNuclear localization signal
TgeneBRWD3chrX:122744769chrX:80049271ENST000003732753411659_1719601803.0Compositional biasNote=Gly-rich
TgeneBRWD3chrX:122744769chrX:80049271ENST000003732753411158_1228601803.0DomainBromo 1
TgeneBRWD3chrX:122744769chrX:80049271ENST000003732753411317_1412601803.0DomainBromo 2
TgeneBRWD3chrX:122744769chrX:80049271ENST00000373275341170_209601803.0RepeatNote=WD 1
TgeneBRWD3chrX:122744769chrX:80049271ENST00000373275341213_251601803.0RepeatNote=WD 2
TgeneBRWD3chrX:122744769chrX:80049271ENST00000373275341255_297601803.0RepeatNote=WD 3
TgeneBRWD3chrX:122744769chrX:80049271ENST00000373275341307_347601803.0RepeatNote=WD 4
TgeneBRWD3chrX:122744769chrX:80049271ENST00000373275341353_393601803.0RepeatNote=WD 5
TgeneBRWD3chrX:122744769chrX:80049271ENST00000373275341400_452601803.0RepeatNote=WD 6
TgeneBRWD3chrX:122744769chrX:80049271ENST00000373275341456_495601803.0RepeatNote=WD 7
TgeneBRWD3chrX:122744769chrX:80049271ENST00000373275341502_542601803.0RepeatNote=WD 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for THOC2-BRWD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90658_90658_1_THOC2-BRWD3_THOC2_chrX_122744769_ENST00000491737_BRWD3_chrX_80049271_ENST00000373275_length(transcript)=15436nt_BP=4452nt
ATGTTTGTTTCAGACACAGTTCTAAAGGAACGCCTGGATCCAGAAACACTGGAATCATTAGGGCTTATCAAACAATCACAGCAATTCAAT
CAAAAGTCAGTTAAAATCAAGACAAAACTCTTTTATAAGCAGCAAAAATTCAATTTGTTAAGAGAAGAGAATGAAGGTTATGCCAAGCTG
ATTGCTGAATTGGGGCAAGATTTATCTGGAAGTATTACTAGTGATTTAATCTTAGAAAATATCAAATCTTTAATAGGATGCTTTAATCTG
GATCCCAATAGAGTTTTGGATGTCATTTTAGAAGTGTTTGAATGCAGGCCAGAACACGATGACTTCTTTATATCTTTGTTAGAATCTTAC
ATGAGTATGTGTGAACCGCAAACACTGTGTCATATTCTTGGGTTCAAATTCAAGTTTTACCAGGAACCAAATGGCGAGACACCATCATCT
TTATACAGAGTTGCAGCAGTACTTCTACAATTTAATCTTATTGATTTAGATGATCTTTATGTACATCTTCTTCCGGCTGATAATTGCATT
ATGGATGAACACAAACGAGAAATTGCGGAAGCTAAGCAAATTGTTAGAAAGCTTACGATGGTTGTGTTGTCTTCTGAAAAAATGGATGAG
CGAGAGAAAGAAAAGGAAAAAGAAGAGGAGAAAGTAGAGAAACCACCTGATAACCAAAAACTTGGCTTGTTGGAAGCCTTATTAAAGATT
GGTGATTGGCAACATGCACAGAACATTATGGATCAGATGCCTCCATACTATGCAGCTTCACACAAGCTAATAGCCCTTGCTATTTGCAAG
CTCATTCATATAACTATTGAGCCTCTCTACCGAAGAGTTGGAGTTCCTAAAGGTGCTAAAGGCTCACCTGTTAATGCTTTGCAAAACAAG
AGAGCACCAAAACAAGCTGAGAGCTTTGAAGATTTGAGGAGAGACGTGTTCAATATGTTCTGTTACCTTGGTCCTCACCTTTCTCACGAT
CCCATTTTATTTGCAAAAGTGGTGCGCATAGGCAAGTCATTTATGAAGGAGTTTCAGTCTGATGGAAGCAAACAAGAAGATAAAGAAAAA
ACGGAAGTTATCCTTAGCTGTTTGCTTAGCATTACTGACCAGGTACTACTTCCATCTCTTTCTTTGATGGACTGCAATGCTTGTATGTCT
GAGGAACTATGGGGAATGTTTAAAACATTTCCATATCAGCATAGATATCGTCTGTATGGCCAGTGGAAGAATGAAACTTATAACAGTCAC
CCACTTTTAGTAAAAGTTAAAGCTCAAACAATAGACAGAGCCAAATATATCATGAAGCGCCTAACCAAGGAAAATGTGAAGCCTTCTGGA
AGACAAATTGGGAAGTTGAGCCACAGCAATCCAACCATTTTGTTTGATTATATCTTGTCACAAATACAGAAGTATGATAACTTAATAACA
CCTGTAGTAGATTCATTGAAATACCTCACTTCACTGAATTATGATGTCTTGGCCTATTGTATCATTGAAGCTTTAGCTAATCCAGAAAAG
GAAAGAATGAAACATGATGACACAACCATCTCAAGCTGGCTTCAGAGTCTGGCTAGTTTCTGTGGTGCAGTTTTTCGTAAATATCCAATT
GATCTTGCTGGTCTTCTTCAGTATGTTGCCAATCAGCTAAAGGCGGGCAAAAGTTTTGACCTGCTTATATTGAAAGAAGTGGTACAAAAA
ATGGCAGGAATAGAAATTACAGAGGAAATGACAATGGAGCAACTAGAGGCTATGACTGGTGGAGAGCAGCTAAAAGCTGAGGGTGGTTAT
TTTGGTCAGATCAGAAACACTAAAAAATCCTCTCAGAGATTAAAGGATGCTCTATTGGACCATGATCTTGCCCTTCCTCTCTGTCTGCTT
ATGGCTCAGCAGAGAAATGGGGTAATCTTTCAGGAAGGTGGAGAGAAACATTTGAAACTTGTGGGAAAGCTCTATGACCAGTGTCATGAT
ACCCTGGTGCAGTTTGGTGGGTTTTTAGCATCTAATCTGAGCACAGAAGATTATATAAAGCGAGTGCCTTCAATTGATGTACTCTGTAAT
GAATTTCATACACCCCATGATGCAGCATTTTTCCTGTCTAGGCCAATGTATGCCCATCATATTTCGTCAAAGTATGATGAACTTAAAAAA
TCAGAAAAGGGAAGTAAACAGCAACATAAAGTTCATAAGTACATTACATCATGTGAGATGGTGATGGCGCCTGTCCATGAAGCAGTGGTC
TCCTTACATGTTTCCAAAGTCTGGGATGACATCAGCCCTCAATTCTATGCTACATTCTGGTCATTGACAATGTATGACCTTGCAGTTCCA
CACACCAGCTATGAACGAGAAGTCAATAAACTTAAAGTCCAGATGAAAGCAATTGATGACAATCAGGAAATGCCCCCAAATAAAAAGAAA
AAAGAGAAGGAGCGCTGTACTGCCCTTCAGGACAAGCTTCTTGAAGAAGAAAAGAAACAGATGGAACATGTACAGAGAGTTCTACAGAGA
TTGAAACTGGAAAAGGACAACTGGCTTTTAGCAAAATCTACCAAAAATGAGACCATCACAAAATTTCTACAGCTGTGTATATTTCCTCGA
TGTATTTTTTCAGCAATTGATGCTGTTTACTGTGCTCGTTTTGTTGAATTGGTACATCAACAGAAAACTCCAAATTTTTCCACACTTCTT
TGCTATGATCGAGTTTTCTCTGACATAATTTACACAGTTGCAAGCTGTACTGAAAATGAAGCCAGTCGATACGGAAGGTTTCTTTGCTGC
ATGTTAGAGACTGTGACCAGGTGGCATAGTGATAGAGCCACATATGAAAAGGAATGTGGAAACTATCCAGGATTCCTTACCATATTACGG
GCAACTGGATTTGATGGTGGAAATAAGGCTGATCAATTAGACTATGAAAATTTTCGACATGTTGTACATAAATGGCATTACAAACTAACC
AAGGCATCGGTACATTGCCTTGAAACAGGCGAATATACTCACATCAGGAATATCTTGATTGTGCTAACAAAAATACTTCCTTGGTACCCA
AAAGTTTTGAATCTGGGTCAAGCTTTGGAAAGAAGAGTACACAAAATCTGCCAAGAAGAAAAAGAGAAGAGGCCAGATCTATATGCATTG
GCTATGGGCTACTCTGGGCAGTTGAAAAGTAGAAAGTCATACATGATACCTGAAAATGAGTTTCATCACAAAGACCCCCCTCCGAGGAAT
GCAGTTGCCAGTGTGCAAAATGGGCCTGGTGGTGGGCCTTCTTCATCATCAATAGGAAGTGCATCTAAATCGGATGAAAGCAGTACTGAG
GAGACTGATAAATCAAGGGAGAGATCTCAGTGTGGTGTGAAAGCTGTTAATAAAGCTTCTAGTACCACACCTAAAGGGAATTCAAGCAAT
GGAAATAGTGGCTCTAACAGCAACAAAGCTGTTAAAGAAAATGACAAAGAAAAAGGGAAAGAGAAAGAAAAAGAGAAAAAAGAAAAGACT
CCAGCTACTACTCCAGAGGCCAGGGTACTTGGTAAAGATGGTAAAGAAAAACCAAAGGAAGAGCGGCCAAATAAAGATGAAAAAGCAAGA
GAGACCAAGGAAAGAACGCCGAAGTCTGACAAAGAGAAAGAAAAATTCAAGAAGGAAGAAAAAGCTAAAGATGAGAAATTTAAGACCACT
GTCCCCAACGCAGAATCAAAATCAACTCAAGAAAGGGAAAGAGAGAAGGAGCCATCCAGAGAAAGAGATATAGCAAAGGAAATGAAATCA
AAGGAAAATGTTAAAGGAGGAGAAAAAACACCAGTTTCTGGGTCCTTGAAATCACCTGTTCCCAGATCAGATATTCCAGAGCCTGAAAGG
GAACAAAAACGCCGCAAAATTGATACTCACCCTTCTCCATCACATTCCTCCACAGTAAAGGACAGTCTCATCGAACTCAAGGAATCTTCA
GCAAAGCTCTACATTAATCATACTCCTCCACCACTGTCCAAGAGTAAGGAGAGAGAAATGGACAAGAAAGATTTGGACAAGTCAAGGGAA
AGATCCAGAGAAAGAGAGAAAAAAGATGAAAAGGACAGGAAAGAGCGGAAAAGGGATCACTCAAACAACGACCGTGAAGTGCCACCGGAC
TTAACCAAGAGACGTAAAGAGGAGAATGGAACAATGGGGGTTTCAAAACATAAAAGTGAAAGTCCTTGTGAATCTCCTTATCCAAATGAG
AAAGACAAGGAAAAAAATAAGTCAAAATCTTCAGGCAAAGAAAAAGGCAGTGATTCATTTAAATCTGAGAAGATGGATAAAATCTCCTCC
GGTGGCAAAAAGGAGTCCAGGCATGATAAAGAAAAGATAGAAAAGAAAGAGAAACGGGACAGTTCAGGAGGAAAGGAAGAGAAGAAACAT
CATAAGTCCTCGGACAAGCACAGATAATGAAGACTTTCCATCGTGGCAGCAAATGCACACATTCCTCCAGACTACCTCCTTAAAATTTGT
GAGAGAATTGGTCCTTTACTAGATAAAGAGATCCCTCAGAGTGTTCCTGGGGTACAGACATTATTAGGTGTTGGTCGGCAGTCTCTGCTA
CGGGATGCCAAAGACTGTAAGAGTACACTATGGAATGGGTCTGCTTTTGCGGCTCTGCATAGAGGCAGACCTCCAGAACTACCTGTAAAT
TATGTGAAACCTCCAAATGTGGTGAATATCACCTCTGCCAGGCAATTAACCGGCTGTAGTCGCTTTGGTCATATTTTCCCTTCATCTGCT
TACCAGCACATTAAGATGCATAAGAGAATTCTGGGGCACTTGTCATCTGTCTACTGTGTAGCATTTGACCGAAGCGGGAGAAGAATTTTT
ACAGGTTCAGATGACTGTTTAGTAAAAATTTGGGCTACAGATGATGGACGCCTTCTTGCTACACTTCGTGGACACTCTGCTGAAATTTCT
GACATGGCTGTTAACTATGAAAACACTCTTATTGCTGCAGGCAGCTGTGATAAGGTAGTAAGAGTATGGTGTCTTCGAACTTGTGCACCC
GTTGCAGTCCTTCAGGGCCATTCAGCTTCTATTACTTCCATACAGTTTTGTCCATCAACTAAAGGCACAAACAGATACCTCACTTCTACT
GGTGCTGATGGAACAATCTGTTTCTGGCAATGGCATGTAAAAACAATGAAGTTTAGAGATCGCCCGGTGAAATTTACTGAGAGATCCAGA
CCTGGAGTCCAGATATCTTGTTCATCTTTCAGTTCTGGTGGTATGTTCATTACAACTGGTAGTACTGACCATGTGATTAGAATATATTAT
TTGGGTTCTGAGGTTCCTGAGAAAATTGCTGAATTAGAGTCACATACGGATAAAGTTGTTGCTGTTCAGTTCTGTAACAATGGAGACAGT
TTAAGATTTGTTAGTGGAAGTCGAGATGGAACGGCAAGAATTTGGCAGTATCAGCAACAAGAATGGAAGAGTATAGTGCTAGACATGGCT
ACTAAAATGACTGGCAATAATTTGCCATCTGGAGAAGACAAGATCACTAAACTTAAGGTGACTATGGTGGCCTGGGATCGCTATGATACC
ACAGTTATTACTGCAGTGAACAATTTTCTTTTGAAAGTGTGGAATTCTATCACAGGACAGCTTCTTCATACATTATCTGGACATGATGAT
GAAGTATTCGTTCTAGAAGCCCATCCATTTGATCAAAGGATCATACTTTCAGCAGGTCATGATGGGAACATTTTTATTTGGGACCTTGAC
CGGGGGACCAAAATTCGGAATTACTTTAACATGATTGAAGGCCAAGGCCATGGTGCGGTGTTTGATTGTAAATTTTCACCAGATGGAAAC
CATTTTGCCTGCACAGATTCTCATGGACATTTGCTGCTTTTTGGTTTTGGATGCAGTAAATACTACGAAAAGATTCCAGATCAGATGTTC
TTCCACACGGATTATCGTCCTCTTATTCGTGATGCCAATAACTATGTATTGGATGAACAAACCCAACAAGCTCCTCACCTCATGCCTCCT
CCATTTTTGGTGGATGTTGATGGAAATCCTCATCCCACAAAATTCCAACGGTTGGTACCAGGACGGGAAAATTGTAAAGATGAACAGCTT
ATACCACAGCTGGGATATGTGGCTAATGGTGATGGTGAGGTAGTAGAACAGGTAATTGGGCAGCAAACCAATGACCAAGATGAGAGCATT
CTTGATGGAATAATCAGGGAGCTGCAGAGAGAACAAGACCTGAGACTAATTAATGAAGGAGATGTTCCACATTTACCAGTTAATAGAGCA
TACTCTGTTAATGGTGCTCTGAGAAGTCCAAACATGGACATATCTTCTTCCCCAAACATCAGGCTTCGAAGACATAGTAGTCAAATTGAA
GGTGTTAGACAAATGCATAACAATGCTCCTCGGAGCCAGATGGCCACTGAAAGAGATCTCATGGCGTGGAGCAGAAGAGTGGTGGTCAAT
GAACTAAATAATGGGGTTAGTAGGGTACAGGAAGAATGTCGAACTGCAAAAGGTGACATAGAAATCAGTCTTTATACAGTTGAAAAGAAG
AAAAAGCCATCTTACACTACTCAAAGGAATGATTATGAGCCTAGCTGTGGGCGTTCTTTACGCAGGACACAGCGCAAACGTCAGCATACT
TACCAAACACGGTCCAACATAGAGCATAATTCACAGGCATCATGTCAAAATTCAGGTGTACAGGAAGACTCAGACAGTTCTTCAGAGGAA
GATGAAACTGTTGGCACAAGTGACGCTTCGGTAGAGGATCCTGTTGTTGAATGGCAAAGTGAAAGTTCTTCCAGTGACTCATCAAGTGAA
TATTCTGATTGGACAGCAGATGCTGGAATAAATTTACAACCCCCAAAAAGACAAACCAGACAGACAACACGTAAAATATGCAGCAGCTCT
GATGAGGAAAATTTGAAGTCCCTAGAAGAAAGGCAGAAGAAACCTAAGCAGACTAGAAAGAAGAAAGGAGGACTGGTTTCTATAGCAGGT
GAGCCTAATGAAGAATGGTTTGCCCCTCAGTGGATCTTGGATACTATACCCCGACGTTCCCCATTTGTCCCACAAATGGGAGATGAGCTT
ATCTATTTTAGGCAAGGACATGAAGCTTATGTTCGGGCTGTAAGGAAATCGAAAATATACAGTGTTAATTTACAAAAACAGCCATGGAAC
AAAATGGATCTCAGGGAGCAAGAGTTTGTTAAGATTGTAGGAATCAAATATGAGGTTGGCCCACCCACACTGTGCTGCTTGAAGCTTGCA
TTTCTGGACCCAATTTCAGGCAAAATGACTGGAGAATCTTTTTCCATTAAGTATCATGACATGCCGGATGTCATTGACTTCCTTGTGCTA
CATCAGTTTTATAATGAAGCCAAAGAAAGGAACTGGCAGATTGGTGATAGATTCCGCAGTATAATAGATGACGCCTGGTGGTTTGGGACT
GTGGAGAGTCAGCAGCCTTTTCAACCAGAGTATCCTGATAGTTCTTTCCAGTGTTACAGTGTTCACTGGGACAATAATGAGAGAGAAAAG
ATGAGCCCATGGGATATGGAGCCAATTCCAGAAGGAACTGCCTTTCCAGATGAAGTTGGTGCTGGTGTTCCTGTCTCCCAGGAAGAATTG
ACTGCTTTGCTATACAAACCCCAGGAAGGAGAGTGGGGGGCTCATTCCAGAGACGAAGAATGTGAACGGGTTATTCAGGGCATCAACCAC
CTTCTTTCCCTGGATTTTGCCAGCCCTTTTGCTGTTCCAGTGGATCTCAGTGCCTACCCCTTGTATTGTACTGTAGTTGCTTATCCAACT
GACCTCAATACCATCAGGCGGAGACTTGAAAATCGCTTTTACAGGAGAATATCAGCATTAATGTGGGAGGTACGCTATATTGAACATAAT
GCCAGGACTTTCAATGAGCCAGACAGTCCTATAGTTAAAGCAGCTAAAATTGTAACTGATGTCTTACTTCGATTTATTGGGGATCAGAGC
TGTACTGATATACTGGATACTTATAATAAAATTAAAGCAGAAGAACGAAACAGTACTGATGCAGAGGAGGATACAGAAATTGTTGATTTA
GATTCAGACGGTCCTGGTACTTCATCTGGAAGAAAGGTCAAATGCCGAGGCAGAAGACAGTCTTTAAAGTGTAATCCTGATGCTTGGAAA
AAACAATGCAAGGAACTATTGAGCCTCATTTATGAACGTGAAGACTCGGAGCCATTTCGACAGCCAGCTGATCTTCTTTCTTACCCAGGT
CATCAGGAGCAAGAGGGAGAATCCTCAGAGTCTGTTGTTCCAGAAAGACAACAAGATTCATCTCTTTCTGAGGATTATCAAGATGTTATA
GATACTCCTGTGGACTTCAGCACTGTGAAAGAAACTTTGGAAGCAGGAAACTATGGTAGTCCTCTGGAATTTTATAAGGATGTTCGCCAA
ATATTCAACAACTCCAAAGCTTATACCTCTAATAAAAAGTCAAGGATCTATAGCATGATGCTGCGATTATCTGCCTTATTTGAAAGTCAT
ATCAAAAATATCATCTCTGAATATAAGTCAGCAATCCAGAGTCAGAAGAGGAGAAGGCCACGGTACAGAAAACGTCTAAGAAGCAGCAGC
AGTTCATTATCTAGTAGTGGAGCACCTAGTCCAAAAGGGAAGCAGAAACAAATGAAGTTGCAGCCTAAAAATGACCAGAATACCTCAGTA
TCTCATGCCAGGACTAGCTCTCCTTTCTCATCTCCTGTTTCAGATGCTGCTGAAGGGCTTTCACTATATCTACTTGATGATGAGCCAGAT
GGGCCATTTTCTTCATCGAGCTTCGGTGGATATAGCCGAAGTGGAAATAGCCATGACCCAGGGAAAGCCAAATCATTTCGGAATAGAGTT
TTGCCAGTTAAACAAGATCACTCCCTTGATGGACCCCTTACAAATGGTGATGGCAGAGAGCCCCGGACAGGAATCAAGAGAAAACTACTT
AGTGCATCAGAAGAAGATGAAAACATGGGAGGAGAAGATAAAGAGAAAAAAGAAACAAAAGAGAAATCTCATTTATCCACCTCAGAGAGT
GGAGAGTTAGGATCCAGTTTAAGTTCTGAAAGTACCTGTGGTTCTGACTCTGACTCTGAATCAACTTCCAGAACAGATCAAGATTACGTA
GATGGAGACCATGATTATAGCAAATTCATACAAACCAGACCTAAAAGAAAACTCAGAAAGCAACATGGCAATGGAAAAAGAAATTGGAAG
ACCAGAGGCACAGGAGGAAGAGGCAGATGGGGAAGATGGGGTAGATGGAGTAGAGGAGGCAGAGGAAGAGGAGGCAGGGGACGAGGGAGT
CGAGGAAGAGGTGGAGGTGGCACTAGGGGGAGGGGAAGAGGGAGAGGAGGAAGAGGTGCTTCTAGAGGAGCTACCAGAGCCAAACGAGCA
CGTATTGCAGATGATGAATTTGATACCATGTTTTCAGGACGTTTCAGTAGACTGCCTCGAATTAAAACAAGAAACCAAGGCAGGAGGACT
GTTTTATATAATGATGATTCTGATAATGACAATTTTGTGTCCACTGAGGATCCTCTGAATCTTGGTACATCCAGATCAGGCAGAGTGCGT
AAAATGACAGAAAAAGCCAGGGTTAGCCATCTCATGGGATGGAATTATTAACAGTTAATAAATTTAGAATAACTTAAAAAATTCAATGGC
CTTCTACTGCAGGGAATTTACCAGGAAATCTACAAAGCAAGTTGTGTGGGGACTTCTGCTTCCTTTCACATTGGTGCTTTTCCATTTATG
CCAGTATACATTTGTTTCAAGACTTTTGATCTCCACACTTCATTTGTTCAAATAAGCCTTACTCATTAGGCCTTAAATTAAAAGAAATTC
TGCCCACACACACACAAACACATACACACACATACACACACACAGACACACACACACGAAACACAACACAGACACTACAGATTTACTACA
TTAAAGGAGCATTCAGCTTCTTAAGAGTAGCATGACATTTTTATCTCAATAGAATAGCCCTCTTTTGCTTTTGTATCACAGAAGTATAGC
ACCTTCTTACAGAGTTTTATATAGTTTGTTTTTGCCATTTTGATTCCTATACCCAGTAATAATAACTTTTGCACAATACACCAATCCTAA
AGGCAGCTATTAAATGTTTACAGTTTCTATATTGTAAGAGCGATCTGGATTATTTTACTCTTCCCAGGCCAAACTTTCATGACTTGTACT
GAACTGAAGTATATATTTATACTACAGTTTTTTGGGGGGTGGGGGGATCTTGATATGCTTTTCATTGATTTGCATAATTCACGTTAAAGG
TGAGAAAGGGTTGGTGCCTTGTAAATATGTAGCAGATCTTCGTGGTGTGTTCTGATGTGTGCATTAACTTTATTAAAAAAGAATACTTGA
GGTATCAATCTAGACAAGGTGCCAAATGCAAAAGTTTCCCGCATCAATTTTTTTCCTATCACATTTTATTGCATTAATAGAATTTGTGTA
GCTTAAATAACTTAAACATTTGAAAAATCCTCATCCACAAAGAACAACTTCTTTGAACAGTAGCTCAGCTACCTCTTAACTACAACTACT
GGAAACATTAAGGAAAATAGATGCTGTTATTCCTTACTGACTAAGGAGAAATAGAACAAGCTTAGTAGGAATGAATACCCCATAAGTTAT
AAGCTGAGAGGTTGTTAATAATTGTATTGGCTCTCAAATTAATAATTGTAATTAACAAAGTTTCATAAATATAGTATGCTCTACCACCTT
AGGCTTTCTTAGAACATATTTGTGTAAGTAGACTTGGGCTACTGCTTATATATTTCTGCTCCACTTACCATTTAACAGCTGTGAGTTGCT
GGTTTTCATTTGAATCTTAAAATTTAACAAAGCACCTGGTTTGATTTGGAATGTTTTGGCTAGCTAGTATTATGAATCAACTTATAGATT
CTGCTCATATCATTCCAAAGGGTTCTTCTGTTCTAGTCTTTCAGGAAAGAACCTTATTGCACTGCACACTCATGTTGTGAATCATTATTT
TATAGATAAAAAACATCTTTAAAAACCCTTATTGTCTTGTTTACAGCAGTAGAGTGCACATGGTTCCATAAGTGAGCTTGAGTTCCAAGG
TCAGTTTTACTCCCCAAATTTAATATTACAGATTTGTTCATTTGTTAGATACTTACATTTCTGAGGTAAGAGGGATAATAGCAATTTCTG
TTTCTGTAACAGCAAATTTGTTGCACTTAGATCAGGCTCATGGGATAAAACAGACTTCTTAGTATATACCTAGCTATCCCAGGATATTTC
TTAAGCTAATGTGTTTGTCTCATGCTTTCAATCATTTCATGCATCTGAAAACCCTTAAGTGCAGAGGAAGGCGTACACACATAAAACTTT
GCTTTTTTGGTAGGGTCGGCAGTAGGGTTATTCTTGGACTAACATCTTTAAGCAGTTTTCACTTGCAGTGGAAATGATGTTCAGGCTTTA
AGAGAAAGTATTGTGAATTGTTAATGGCACTAACTTCTGTTACTAGACAGCAGACCAAGCTATTTTTTTGTTGTAGTCTTTTTTTCACTA
AACCAAAACTACTTCTGGTTGTAACTCAGCTGCCACTTTAAACCATAGTAGAGATTCAAAACGTTCCTATTTGAAACTACATTTGATTTT
TGCTAAAATGTGCTGTTTCGGTTATTTATCTCTTGGGCATTTAGACTAAATTGTGCCTGTATTCCTGAAATCAATAATACTTTGGCTTAT
CCTGATCTAAGTAACATAGTTACTTAAATTCCTGGATATACCCAAATATGGATCACATGTATCATTTTAGTTTGAAATTTTTTGTTGACA
TTCTTCTATGAAGAGCTGACCTCTTGAAATGTAGAAGAATTGACATTTGTGTGATTTTGGCTATCTGGAGCTTTATTTATAATTTATTTT
GAAAAATAAAAATGCCACATTTATTTCCCAAATGTCAAGATTTTCTAGAATTAGATAATTAGAATAATAAGGCTGAAGACATTTTAAAGC
ATATTTTATATGTAGTGAAATACTGTGAAAATATTAGTGAACAGCATTTTGCTGTAATGTTTATTTCAGTTATTAAGATTTAAAGAGTTA
GTCATCAGGGTATGTTAGATAAACATAGTTATCATTTATTAAACAAACAGATAATTTTCTGTTTGCATGCAAATTATTTTAATAAGTGTG
AAAATAAAAGTTTGGAAGATAGTATTTTTACTTTTATATCTGGACTTTTTTTTCCCCCAATTTACACTTTGCTTTCTTGTAATACCACCT
CCTGTGAATGTGTTGTAATTAGTATCACATTGATTACTTTATCATTTTAATTTCTTTGAGGCCCTTTAAACCTACGTAAAATCTGGGTCC
AGCCATAGCAAAGCAAGTACAAAATGAACAAAGAATTTTGAAGAAAAGCCTAAATCTTAAATTGCTAAGAAAAAACACTGTTATATTTAG
GCCCGTGAGAGCATATACATGTATAAACCTAATCCTATGCTAGATATGAATAGTCAGTGAGCTGTAATATTTCTCATAAATGCTAATAAT
GTTTAAATTCCCAGCTTTAAGATCTTAGTGTGTGTATATATTTATAAAATCTGAATTGTGTGTTTCTTCTATGGCTTACTGTGTGTTTCT
CTTTCAGCAATAGGATGCTCTCTAAAACATTCACTAGCCTACTAGCCTACTTACTAAATTTTTGTATATGTGTGTTTGTGCACTTGTATG
TGTGTAAAGTTTTTTCCCCAACTTGACACACCTTATCTCAGACATTCAAAAAAAGAGAACATTTTGTATGGAGGACAGTCTGCCAACTTT
TTGCCTCTCTACAGCTCTTAGCCTGTATATTTACTGCTTGATCATTCATTATGCCTTCTAGATAACCAGTCCAGGTTTTGTCATATACCT
GTGTCCCTCTATTCTTTTTATTTCCCTTTTTAATTTTTTTTCTTTTTTTTCCCTCCCCAGAAATCAGGCTTGTGTTGGAATTCTTCTCTA
TAATACTTTGTTTCCCGCAGATGCAAAGTAACAAAGTAACTGAGTAAAATTAGAAATCTCATTCTGCACAACTGTGCGCTCAGATATTTA
ACTCAGCCTTCTAATACTTTTAAGTACGTTTCTGTTATTTATCTTTTTGTTGTTTTTGTTTTAATCCCATAGATTGTCATCAGACAATAA
TAGAGTGATTGAGAGAGAAAGATATAAATGCCACTTCTAACTTTTTGATAAAACTTTTTTGAGCATTTTTCAAAAATTTGTATGTTTGTG
GTAATGGGGAATTAAACACCTTTTACAGCTGATGTATGTTGGAAATCATTTTATGTACATTTACCAACTGGTACTTATCTTCAAGTTGGA
ATTTTCACATCCATAAAAGGGAGACTTGCATCATATATAATTTTCAGTATACTTTGCTGTCCAGCCTTTTAAACAATTACAGTAACATTT
TGAGTTCTGTGATGAATAGTTCTAGGGGAAGGGATGGAACTTTCGACATGTAAAGTCCATTGTTTTAAATGCTAACCCCATCCCCAATAT
TTTTGTGGAACGTGAGGCTTTATGAAAGGTTTATCAGAAATAGAATATTCTAAAGTCACTTTTATGGCTTATTTCAAAAACTAGTGTGAA
AGTATTTTCATGCTTTTTTGTTTCTCATCTTTTAGCAAAGCTTCTTTACCAAGTTTTGATTAAATTGCAATATAAAATTAAGTTTTTTCA
CGGTGCTATATTTTGTGGAATATGGGTAGCACTCAGGTTTCTTTCTTTTTTCTTTTCTCCTTCCTTCTTCCTTCATTCCTTCATTCCTCC
CTCCCCCCTCCCTCCCTCCCTCTCTTCCTTCCCTCCTTCCTTCCTTCCTCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCC
ACCGTGCCCGGCCTATATACCCTTATTCTTGATTATTTCTTTTTTCATCTTTTCAATCCTGCTTACTTTTATCCTCACTTTTCTTTCTGC
CATGAAAACTGCACCTAATTTACCACACTTAAGATTGGCAATTTTTGATTCATTGATGGGAGAAGTACAGTAGAAAGGCCCTGCAGTTTA
GAATTAAGTTGTGTTTGTTTATTTACATGTATGCCCATTTCTTCTAAATTAAATCTAGAATGTGAGACTTTGACATATAAAAGCATGATA
AGTATTTTCTTAAAAAATAAGACTATTGATACATAATGAAACCACCATTGGTAATTGAATTTTAAAATGATATGCAAAAATATTTAGAAA
TCCAGTTGGGAAATGTGTTTTTGCATATGTCACCAGATACACATTAGGCAGTACTACAAATGTTAATTCTTAAACAATACTGTGGTGATG
GCAATCAGTAATTTATTTCTTTGTCCTGTAACTTATCATTCTTGTCTTTTGTAATGTCTTACACAGTATTAACATAACTGTACCTTTTTT
TTGTTCTTGGTATCCATACATTTTAAGATGGAAAATCAGTTCATAGTTGATATGATATTGTATATGGGCAAAATGTCCGTTAAACTAAAA
TTCAGTAAAAAAGGTAATATAAACTGGCTTGATTTATAAAAGATGTTTTGTTTGGCAGTTATCAGTCATTATAAGCAATTATCTTCAAAG
ACAAAAAAACTGGACTAATTTGTTGCCATTCTTTATGGGATGTTTACAATAAAATTCCAAGTTGTTTGGAATCAATTGCACTCTTGCTGC
TTTATGCCTTAATTTATGTACCAGAGAAAAATTAACCAGAAGAAAGAAATATGGAGTTACCTATTCAGCTTTAGAGATTGTAACATGTAA
CTCTTAGGTCTTTCTTGTTTCTTTGTCATAGAATATTTTATTACTATTACTTTTTAATCTGAGAAACTAGGATGCTTCTTCCTATCAAAG
AAAAGGTTTTGTTTTTTGTTTTCATCTTAGACATTGCAAATATTCTTTGGGTCACTTTTAGGATAATAAATATGATGTTTACACTTTAAA
TGTGGGCTGCTTGGTGCATTCAATAACAGCCTGCAAAGCATTTGTCAACATTTTGTTTTGCAGAGCTTTTCAAAATGAATAGATCTCTAA
CATATTTATGACTTACAACTTTTAACAGCTGAGTTATATGTACCTGACATTTTAAAATGTATAGTAAGATTACCTACATTGTAAATGGTG
CTTTAATTCAGTGTAAGTGTAGGAGAGAGAGAAGTGAGGTGAGATGATCTGAATGCTCTAACAGGAACATTCATAACTATATAGTTACCC
AGAATTTGTCTCCCAGTGGCAAACATTCCACTAGGTTCAAGATAAATAAGCTGGCCAAAGACTGGACTGTATCTTTGATATATATATACT

>90658_90658_1_THOC2-BRWD3_THOC2_chrX_122744769_ENST00000491737_BRWD3_chrX_80049271_ENST00000373275_length(amino acids)=1698AA_BP=
MLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGHIFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRR
IFTGSDDCLVKIWATDDGRLLATLRGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPSTKGTNRYLT
STGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFITTGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNG
DSLRFVSGSRDGTARIWQYQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVWNSITGQLLHTLSGH
DDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMIEGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQ
MFFHTDYRPLIRDANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVANGDGEVVEQVIGQQTNDQDE
SILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVNGALRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVV
VNELNNGVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHTYQTRSNIEHNSQASCQNSGVQEDSDSSS
EEDETVGTSDASVEDPVVEWQSESSSSDSSSEYSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLVSI
AGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQKQPWNKMDLREQEFVKIVGIKYEVGPPTLCCLK
LAFLDPISGKMTGESFSIKYHDMPDVIDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVHWDNNER
EKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEECERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAY
PTDLNTIRRRLENRFYRRISALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEERNSTDAEEDTEIV
DLDSDGPGTSSGRKVKCRGRRQSLKCNPDAWKKQCKELLSLIYEREDSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQD
VIDTPVDFSTVKETLEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKSAIQSQKRRRPRYRKRLRS
SSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSPFSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRN
RVLPVKQDHSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELGSSLSSESTCGSDSDSESTSRTDQD
YVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWKTRGTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAK

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Fusion Gene PPI Analysis for THOC2-BRWD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THOC2-BRWD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THOC2-BRWD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource