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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THOC5-TTC28 (FusionGDB2 ID:90681)

Fusion Gene Summary for THOC5-TTC28

check button Fusion gene summary
Fusion gene informationFusion gene name: THOC5-TTC28
Fusion gene ID: 90681
HgeneTgene
Gene symbol

THOC5

TTC28

Gene ID

8563

23331

Gene nameTHO complex 5tetratricopeptide repeat domain 28
SynonymsC22orf19|Fmip|PK1.3|fSAP79TPRBK
Cytomap

22q12.2

22q12.1

Type of geneprotein-codingprotein-coding
DescriptionTHO complex subunit 5 homologFms-interacting proteinNF2/meningioma region protein pK1.3PP39.2functional spliceosome-associated protein 79hTREX90placental protein 39.2tetratricopeptide repeat protein 28TPR repeat protein 28TPR repeat-containing big gene cloned at KeioTPR-containing big gene cloned at Keio
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000397871, ENST00000397872, 
ENST00000397873, ENST00000490103, 
ENST00000490475, ENST00000397906, 
Fusion gene scores* DoF score12 X 13 X 7=109238 X 29 X 5=5510
# samples 1341
** MAII scorelog2(13/1092*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/5510*10)=-3.74835650395307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THOC5 [Title/Abstract] AND TTC28 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHOC5(29945041)-TTC28(28702631), # samples:1
Anticipated loss of major functional domain due to fusion event.THOC5-TTC28 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTHOC5

GO:0006406

mRNA export from nucleus

17190602

HgeneTHOC5

GO:0030224

monocyte differentiation

19015024

HgeneTHOC5

GO:0046784

viral mRNA export from host cell nucleus

18974867


check buttonFusion gene breakpoints across THOC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TTC28 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-SN-A6IS-01ATHOC5chr22

29945041

-TTC28chr22

28702631

-


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Fusion Gene ORF analysis for THOC5-TTC28

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000397871ENST00000490475THOC5chr22

29945041

-TTC28chr22

28702631

-
5CDS-5UTRENST00000397872ENST00000490475THOC5chr22

29945041

-TTC28chr22

28702631

-
5CDS-5UTRENST00000397873ENST00000490475THOC5chr22

29945041

-TTC28chr22

28702631

-
5CDS-5UTRENST00000490103ENST00000490475THOC5chr22

29945041

-TTC28chr22

28702631

-
Frame-shiftENST00000397871ENST00000397906THOC5chr22

29945041

-TTC28chr22

28702631

-
Frame-shiftENST00000397873ENST00000397906THOC5chr22

29945041

-TTC28chr22

28702631

-
In-frameENST00000397872ENST00000397906THOC5chr22

29945041

-TTC28chr22

28702631

-
In-frameENST00000490103ENST00000397906THOC5chr22

29945041

-TTC28chr22

28702631

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000490103THOC5chr2229945041-ENST00000397906TTC28chr2228702631-1148921912372832386
ENST00000397872THOC5chr2229945041-ENST00000397906TTC28chr2228702631-1170143120374952430

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000490103ENST00000397906THOC5chr2229945041-TTC28chr2228702631-0.0015924190.99840766
ENST00000397872ENST00000397906THOC5chr2229945041-TTC28chr2228702631-0.0019238590.9980761

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Fusion Genomic Features for THOC5-TTC28


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THOC5-TTC28


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29945041/chr22:28702631)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHOC5chr22:29945041chr22:28702631ENST00000397871-2207_1032684.0MotifNuclear localization signal
HgeneTHOC5chr22:29945041chr22:28702631ENST00000397872-3217_1032684.0MotifNuclear localization signal
HgeneTHOC5chr22:29945041chr22:28702631ENST00000397873-3217_1032684.0MotifNuclear localization signal
HgeneTHOC5chr22:29945041chr22:28702631ENST00000490103-2207_1032684.0MotifNuclear localization signal
TgeneTTC28chr22:29945041chr22:28702631ENST000003979061231948_20061272482.0Compositional biasNote=Ser-rich
TgeneTTC28chr22:29945041chr22:28702631ENST000003979061232201_23351272482.0Compositional biasNote=Ser-rich
TgeneTTC28chr22:29945041chr22:28702631ENST000003979061231037_10701272482.0RepeatNote=TPR 25
TgeneTTC28chr22:29945041chr22:28702631ENST000003979061231077_11101272482.0RepeatNote=TPR 26
TgeneTTC28chr22:29945041chr22:28702631ENST000003979061231117_11501272482.0RepeatNote=TPR 27
TgeneTTC28chr22:29945041chr22:28702631ENST000003979061231169_12021272482.0RepeatNote=TPR 28
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123126_1591272482.0RepeatNote=TPR 3
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123196_2291272482.0RepeatNote=TPR 4
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123234_2671272482.0RepeatNote=TPR 5
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123274_3071272482.0RepeatNote=TPR 6
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123314_3471272482.0RepeatNote=TPR 7
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123354_3871272482.0RepeatNote=TPR 8
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123394_4271272482.0RepeatNote=TPR 9
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123434_4671272482.0RepeatNote=TPR 10
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123474_5071272482.0RepeatNote=TPR 11
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123514_5471272482.0RepeatNote=TPR 12
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123554_5871272482.0RepeatNote=TPR 13
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123594_6271272482.0RepeatNote=TPR 14
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123634_6671272482.0RepeatNote=TPR 15
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123674_7071272482.0RepeatNote=TPR 16
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123714_7471272482.0RepeatNote=TPR 17
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123754_7871272482.0RepeatNote=TPR 18
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123794_8271272482.0RepeatNote=TPR 19
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123834_8671272482.0RepeatNote=TPR 20
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123877_9101272482.0RepeatNote=TPR 21
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123917_9501272482.0RepeatNote=TPR 22
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123957_9901272482.0RepeatNote=TPR 23
TgeneTTC28chr22:29945041chr22:28702631ENST00000397906123997_10301272482.0RepeatNote=TPR 24

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTTC28chr22:29945041chr22:28702631ENST0000039790612358_911272482.0RepeatNote=TPR 1
TgeneTTC28chr22:29945041chr22:28702631ENST0000039790612393_1251272482.0RepeatNote=TPR 2


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Fusion Gene Sequence for THOC5-TTC28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90681_90681_1_THOC5-TTC28_THOC5_chr22_29945041_ENST00000397872_TTC28_chr22_28702631_ENST00000397906_length(transcript)=11701nt_BP=431nt
GGGCAGTGGGGCTGGGAGATGGGGCGGGGCTGGGCGCTCCGGGACTGAGGTGCTGATCGCCCAAAGGGCGCCCCTGGGCTGGGGTCTGAC
CCGGCTTCTCCTCCCTCACTACCCGCGGTCCCCGGCCTCTCGGCGCTGCGCTGTTACCTCATCCGAAAAGTGTTCGCTGCAGCATCCTCA
GGCTTCACGTTGGAGCCTCTTGATTGTGGTGTTCAGCATTATTTAAGATCACCTATGCATCATCTGAAGCCACAGTCCCAGGTCATCTTC
ATCACCTTCCCCAGTGGAATGCCTCCTGTGTTAAAGCCCACAACAACCCCTGTGGAGGAACAACCATGTCATCAGAATCGAGCAAAAAAC
GGAAGCCCAAAGTGATCCGAAGCGATGGAGCCCCAGCTGAAGGAAAGCGGAATCGATCTGACACCGAGCAGGCATACTTCCGACAGGGTG
TTGCCCTCCAGTACCTTGGACGTCATGCCGATGCCCTGGCAGCCTTTGCATCTGGACTGGCTCAAGACCCCAAGAGTCTCCAGCTTCTGG
TGGGGATGGTGGAAGCCGCCATGAAATCTCCCATGAGAGACTCCCTCGAGCCCACTTATCAGCAGCTTCAGAAAATGAAACTGGACAAGA
GTCCCTTTGTGGTCGTGTCTGTGGTTGGGCAGGAACTCCTGACAGCTGGCCATCATGGGGCCTCTGTGGTTGTCTTAGAAGCCGCACTGA
AGATTGGCACCTGCAGCCTCAAACTGAGAGGTTCTGTTTTCTCTGCCCTGAGCAGTGCTTACTGGTCTCTTGGAAATACAGAGAAGAGCA
CCGGATATATGCAGCAGGACTTGGATGTAGCCAAGACCTTAGGTGACCAGACAGGAGAATGCCGAGCTCATGGGAATCTGGGCTCTGCAT
TCTTCTCCAAAGGAAATTACCGGGAGGCTCTCACTAACCACAGGCATCAGTTGGTACTCGCCATGAAACTCAAAGATCGAGAGGCAGCTT
CATCAGCCTTGAGCAGTCTGGGCCACGTGTACACAGCCATTGGAGACTACCCCAATGCACTGGCCAGTCACAAACAGTGTGTTCTTCTTG
CCAAGCAATCCAAAGATGAACTTTCTGAAGCCCGAGAACTTGGCAACATGGGAGCTGTGTATATTGCCATGGGTGACTTTGAGAATGCTG
TGCAGTGCCATGAGCAGCATCTGAAGATAGCCAAGGACCTGGGGAACAAGCGAGAAGAGGCCCGGGCTTATAGCAACCTGGGCAGTGCCT
ATCACTACCGGAGGAACTTTGACAAGGCCATGTCTTACCATAACTATGTCCTGGAGCTGGCACAGGAGTTGATGGAGAAGGCTATTGAGA
TGCGGGCCTATGCTGGACTAGGCCATGCTGCCAGGTGCATGCAGGATTTGGAGAGAGCTAAACAATACCATGAGCAGCAGCTGGGCATTG
CTGAGGATCTCAAGGACCGGGCTGCAGAGGGGCGAGCATCCTCCAATCTAGGAATCATACACCAGATGAAAGGTGATTATGACACTGCAC
TGAAACTCCACAAGACCCACCTGTGCATTGCCCAGGAGCTGAGTGATTATGCTGCCCAGGGCCGTGCCTATGGGAATATGGGCAATGCCT
ACAATGCCCTGGGCATGTACGACCAGGCGGTCAAATACCATCGGCAGGAGCTGCAGATCTCCATGGAAGTGAATGACCGCGCCTCACAGG
CCTCCACACATGGGAACCTTGCCGTGGCCTACCAGGCCCTGGGTGCCCATGACCGGGCCCTGCAACACTATCAGAACCACTTGAACATCG
CCCGGGAGCTACGAGACATCCAGAGCGAGGCCCGGGCCCTCAGCAACCTGGGCAATTTCCACTGCTCTCGGGGAGAGTATGTCCAGGCTG
CCCCCTATTATGAACAGTACCTCCGGCTTGCTCCCGACCTTCAAGACATGGAAGGAGAAGGGAAGGTCTGCCACAATCTTGGCTATGCCC
ATTACTGCCTTGGAAACTATCAGGAGGCAGTGAAGTACTACGAACAGGATCTGGCACTGGCTAAAGACCTTCACGACAAGTTGAGCCAAG
CAAAAGCCTACTGCAACTTGGGCCTAGCATTCAAGGCTCTGCTGAATTTCAGTAAAGCTGAAGAGTGTCAGAAGTACCTACTGTCCCTAG
CCCAGTCTCTGAATAATTCCCAGGCTAAATTTCGAGCCCTAGGAAACCTGGGCGATATATTCATCTGTAAAAAAGATATAAATGGTGCAA
TAAAATTCTATGAGCAGCAACTGGGCTTAGCTCACCAGGTAAAGGACAGAAGATTAGAAGCCAGTGCATATGCAGCCCTGGGCACTGCAT
ACCGAATGATCCAGAAGTATGACAAGGCCCTGGGTTATCACACACAGGAACTGGAGGTATATCAGGAGCTGAGTGACTTGCCAGGGGAGT
GCAGAGCTCATGGGCACCTGGCTGCTGTCTACATGGCCCTTGGGAAATACACAATGGCATTCAAGTGTTATGAAGAGCAACTGGATCTAG
GGCAAAAGCTGAAGGATCCGAGTCTGGAAGCCCAGGTCTATGGCAACATGGGCATCACAAAGATGAACATGAATGTGATGGAAGAAGCCA
TTGGCTACTTTGAGCAGCAATTGGCCATGCTGCAGCAGCTAAGTGGAAATGAGTCTGTGCTCGACAGGGGCCGGGCCTATGGCAACCTGG
GGGATTGCTACGAAGCCCTGGGTGACTATGAGGAAGCTATCAAATACTATGAACAATATTTATCTGTCGCGCAGAGTCTGAATCGCATGC
AAGACCAAGCCAAGGCTTACCGGGGCCTGGGAAATGGACACAGGGCAATGGGGAGCTTGCAGCAAGCCCTTGTGTGCTTTGAAAAGAGGC
TCGTGGTTGCTCATGAACTTGGAGAGGCCTTCAATAAAGCCCAGGCCTATGGAGAGCTGGGAAGTCTGCACAGCCAATTAGGGAATTACG
AACAAGCCATTTCCTGCCTTGAACGCCAGCTGAACATTGCTAGAGATATGAAAGACCGAGCCCTGGAGAGTGACGCAGCCTGTGGCCTGG
GGGGCGTTTACCAGCAGATGGGGGAGTATGACACAGCCCTGCAGTACCACCAGCTTGATCTACAGATAGCAGAGGAAACCAACAACCCCA
CGTGCCAGGGCCGAGCCTATGGGAACCTGGGCCTGACTTATGAATCCCTGGGCACCTTCGAGAGGGCTGTGGTCTATCAAGAACAGCACT
TGAGCATTGCTGCACAGATGAATGACTTGGCGGCCAAGACGGTGTCATATAGTAGCCTTGGAAGGACCCATCATGCCTTGCAGAACTATT
CCCAAGCAGTCATGTACTTACAGGAAGGTTTAAGGTTAGCTGAGCAACTGGGCCGAAGAGAAGATGAGGCAAAAATTCGCCATGGCCTTG
GCCTCTCCCTTTGGGCTAGTGGAAACTTGGAGGAGGCCCAACACCAGCTTTATAGGGCATCAGCCTTGTTTGAAACAATCCGACATGAGG
CACAGCTGAGCACGGACTACAAACTCTCCCTCTTTGACCTGCAGACATCATCCTACCAGGCCTTGCAGCGGGTGCTCGTCAGCCTAGGCC
ATCATGATGAAGCCCTGGCTGTGGCAGAAAGGGGACGGACAAGGGCATTTGCTGATCTTCTGGTGGAACGACAAACAGGACAACAAGACT
CCGACCCCTACTCCCCAGTCACTATTGATCAGATCTTAGAGATGGTAAATGGCCAGAGGGGACTAGTGCTTTACTATTCCCTGGCTGCAG
GCTATCTGTATAGCTGGCTGCTGGCTCCTGGGGCAGGAATTGTGAAGTTTCATGAACACTACCTGGGTGAGAACACAGTGGAAAACTCAA
GTGACTTCCAGGCCAGCAGCAGTGTAACCCTTCCAACAGCAACCGGCTCAGCCCTGGAGCAGCACATTGCCAGTGTCCGGGAGGCCCTGG
GGGTGGAGTCTCACTACTCAAGGGCCTGTGCCAGCAGTGAGACAGAGAGTGAAGCGGGAGACATCATGGACCAGCAATTTGAAGAGATGA
ACAACAAACTCAACTCGGTCACTGACCCCACTGGCTTTCTGCGGATGGTTCGCCGCAATAACCTGTTTAACAGGAGCTGCCAGAGCATGA
CGAGCCTGTTCAGTAACACTGTGTCACCGACCCAGGACGGGACCTCCTCTCTTCCCAGGAGGCAGAGCTCGTTTGCCAAGCCCCCGCTCC
GTGCCCTGTATGACCTGCTCATCGCGCCCATGGAAGGGGGCCTGATGCACTCCAGCGGCCCCGTGGGCCGGCACCGGCAGCTCATCCTGG
TTCTGGAGGGGGAGCTCTACCTCATTCCTTTCGCCCTCCTGAAGGGAAGCTCCTCCAATGAGTACCTCTACGAGCGCTTCGGCCTCCTTG
CTGTCCCTTCCATCCGCTCCCTCAGCGTGCAGTCCAAGTCTCACTTACGGAAGAACCCGCCCACATACTCCAGCTCCACATCCATGGCGG
CTGTCATCGGCAACCCCAAGCTACCATCGGCCGTGATGGACAGGTGGCTGTGGGGGCCCATGCCATCGGCCGAGGAAGAGGCCTACATGG
TGTCCGAGCTGCTGGGCTGCCAGCCCCTAGTGGGCAGTGTGGCCACCAAGGAGAGGGTCATGAGTGCCCTGACCCAGGCTGAATGCGTCC
ACTTTGCCACCCACATCTCCTGGAAGCTGTCGGCCTTGGTCCTCACGCCCAGCATGGACGGCAACCCTGCCAGCAGCAAGAGCTCCTTCG
GCCACCCCTACACGATCCCTGAGTCCTTGCGGGTGCAGGACGATGCCAGTGATGGGGAGAGCATCTCGGACTGCCCGCCCCTGCAGGAGC
TGCTGCTTACTGCCGCCGACGTCCTGGACCTGCAGCTGCCTGTGAAGCTGGTGGTGCTTGGCTCCTCCCAGGAGTCCAACAGCAAAGTCA
CAGCCGACGGGGTCATCGCGCTGACAAGGGCCTTCCTGGCTGCCGGCGCTCAGTGTGTCCTCGTGTCTCTGTGGCCTGTGCCAGTGGCTG
CTTCTAAGATGTTCATCCATGCCTTCTACTCATCCCTGCTGAACGGCCTGAAAGCCAGCGCCGCCCTGGGGGAGGCCATGAAGGTGGTGC
AGAGCAGCAAGGCCTTCTCGCACCCCTCCAACTGGGCAGGGTTCATGCTCATCGGGAGTGACGTTAAGCTGAACAGCCCCTCATCACTCA
TCGGCCAGGCCCTCACAGAGATCCTGCAGCACCCGGAGCGTGCGCGGGACGCCCTGCGAGTGCTGCTGCACCTGGTGGAGAAATCCCTGC
AGCGCATCCAGAATGGGCAGCGCAATGCCATGTACACATCCCAGCAGAGTGTGGAGAACAAAGTGGGCGGCATCCCTGGCTGGCAGGCCC
TCCTCACCGCTGTGGGCTTCCGGCTGGACCCCCCAACCAGTGGCCTGCCAGCGGCTGTCTTCTTCCCAACCTCCGACCCGGGCGACCGGC
TCCAGCAGTGCAGCAGCACACTCCAGTCCCTGCTGGGTCTGCCCAATCCTGCCCTCCAAGCCCTTTGCAAACTCATCACTGCCTCCGAGA
CGGGCGAGCAGCTCATCAGCCGGGCTGTTAAAAATATGGTTGGAATGCTCCACCAGGTGCTGGTTCAGCTCCAGGCTGGCGAGAAGGAGC
AGGACTTGGCATCAGCTCCCATTCAGGTCTCCATCAGCGTCCAGCTGTGGCGGCTCCCGGGATGCCACGAGTTCCTGGCAGCTCTAGGTT
TTGATCTCTGTGAAGTTGGTCAGGAGGAAGTAATCCTGAAAACCGGGAAGCAAGCTAATCGACGGACTGTGCACTTCGCGCTCCAGTCCC
TGCTGTCTCTGTTTGATTCTACTGAGCTACCCAAGCGCCTCAGCCTTGACAGCTCCTCCTCCCTCGAGTCTCTTGCTTCTGCTCAGTCTG
TTTCCAACGCCCTGCCCTTGGGTTACCAGCAACCCCCCTTCTCTCCCACCGGTGCGGACAGCATCGCCTCAGATGCCATCTCTGTGTACA
GTCTGAGCTCCATTGCCTCCTCAATGAGCTTTGTCTCCAAACCCGAGGGTGGATCAGAGGGTGGAGGCCCCGGAGGACGGCAGGACCATG
ACCGGTCCAAGAACGCTTACCTGCAGAGATCCACCCTGCCTAGGAGCCAGCTGCCTCCCCAGACCCGCCCTGCAGGCAACAAAGATGAAG
AAGAATATGAAGGGTTTTCTATCATCAGTAACGAGCCCTTGGCGACCTACCAAGAAAACCGAAACACATGCTTCTCACCAGACCACAAAC
AACCCCAACCTGGGACAGCCGGAGGCATGAGAGTCTCGGTGAGCTCCAAAGGGAGCATCAGCACTCCAAATTCTCCAGTGAAAATGACTC
TGATTCCCAGCCCCAACTCACCCTTCCAAAAGGTGGGAAAACTAGCAAGCTCAGATACAGGAGAATCAGACCAGTCTAGCACAGAAACGG
ACAGTACCGTGAAATCCCAAGAAGAAAGCAACCCAAAACTGGATCCACAAGAGTTAGCCCAGAAAATTCTGGAGGAGACACAGAGTCATC
TCATTGCGGTGGAGCGTCTTCAGAGGAGCGGCGGCCAGGTGAGCAAGAGTAATAACCCTGAAGACGGCGTTCAGGCGCCCAGCAGCACTG
CTGTCTTCAGAGCGTCAGAAACCAGTGCGTTCAGCAGGCCTGTTCTCTCCCATCAGAAGAGTCAGCCATCACCAGTCACTGTTAAACCAA
AGCCCCCAGCCAGGAGCTCCTCCCTGCCCAAGGTGAGTTCCGGATATAGCAGCCCCACCACCTCAGAGATGTCCATCAAAGACAGCCCGA
GCCAGCACAGTGGCCGGCCATCGCCCGGCTGCGACTCACAGACTTCCCAGCTGGACCAGCCTCTCTTTAAACTGAAGTACCCCAGCTCTC
CTTACAGCGCTCACATTTCCAAATCACCAAGGAACATGTCCCCAAGCTCCGGCCACCAGTCTCCTGCTGGCAGTGCACCCTCCCCAGCTC
TCTCCTACTCCTCAGCTGGATCTGCTCGCTCAAGTCCAGCAGACGCTCCCGACATAGACAAACTGAAAATGGCAGCCATTGATGAAAAGG
TGCAGGCTGTCCATAACCTGAAGATGTTCTGGCAGAGCACACCCCAGCATTCCACAGGGCCAATGAAGATCTTCCGGGGGGCTCCTGGCA
CGATGACTTCCAAAAGGGATGTCCTCAGTCTGTTGAATTTGTCACCACGGCACAATAAGAAGGAGGAGGGAGTGGATAAGCTTGAACTGA
AGGAGCTGTCCCTGCAGCAGCATGACGGAGCTCCACCGAAAGCCCCTCCCAACGGACACTGGCGCACCGAGACCACCTCGCTGGGCTCAC
TGCCGCTGCCCGCCGGCCCTCCCGCCACAGCCCCCGCGCGCCCTTTGAGGCTTCCTTCTGGAAATGGCTACAAGTTCCTGTCTCCAGGAA
GATTTTTCCCTTCTTCCAAATGCTAAAGCATCTTTTATACCCACTGACTCTGAGCAGCCTGCAGATGGGGGCCTGGCGTTTGCTTCAGCC
CTTCCCTGAGTGCAGTCCCCCCACAGCCACCAGCACCCTCATGATGCTGTGCTCTGCAGGCGAGGGGCACCACCACGTCCAAAGGCTGCC
ACACACACTGGTGGCTTTTCTGGGCCACATTCACCAAAAGCCAGGACTTCTGTGGGGCTGGTACAGGAGGCTCATGGAATTTCCTACACA
CTTCACCAAATGTTTGTTTACCTTTGAACTCCCTGCTTCTCATCTTTGATATGATTCTTCACCAGGATTTTGTACAAAAATGATCATGGT
TCTGGGGTGGGGAGAGGAAAGGGAGCACATATTTTGCTAAGAGGTATATATGCAGTACCTTTTATACACAGAAATACAAATAGAGCTTTT
TCTAAGGCTTTCGGTTGCTGGTTGGGGGTGGGATATATGAAATTTCAGTTGAATTCTACAGGAAAGTGTTATATTAGCCAAAAACAGAAA
AATGGTTTTTAAAATGCCAATGATTTGTAATTAAATTGTAGCAATTTTGGTCTCATGATAGTGTAATATCTCAGCAACAATGCAATAATT
CACATTGAAACAGCGCTTCCATTCTGAACTCTGCTCTGCAAATGTCTTTTGGGTCCCGCTGTCAACCAAACTTGAATTTTCTTAAAAAAA
AAATTATGTAACTCTTATCCAGGCATTTTAGAACTATGCAATTGTGATTTAAAATGCAACTTTGTGCTTTTAAAACATTATTGACCTTTT
TTGTATATGGATAAACAACTTGGTTTTATTATCAATAGTACTTTGCATTTATAGCTATTATTTTTAAAAGCTCAAAAAGTTTTTTAAAAT
GTCAAATTTTGAATAGTCATCAATAAGTAATTATCAAGTTTGGAAGGAAAGGTTGAAATGACTCCGTTTCCTTATAAGCAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAATTTCCATGGCTAACTAGATTTAACCAGAATCCCGCCTTCCAGGCTCCTGTTCCCTTTTATTAGC
TGCTGAATTTTATTCCCTTTTCCCAACTCCAGGTCCCTCAGTTGTCTTATATCTAAATCCTTTGCCAGGTCCCCACAATCCCAGCACCTG
CCTCTGTGAGCTGCCCCCAGGCCCTCACCTTGGCCCTGGCCAGCCTCCTGTGCTCCTGCTGTCTGAAGGACTGGCCCCTCCCCCACTGCT
GAAGCCACACGTACAGATCCTAAGCAACAGGGCCTTTTGCTGGGACGTATGCCTGGATTATGGCCAACCGGGAAGAGAGAGATGTATCTT
AAAAAGTGGAGGTGGACTTCTCCTACAGCTCTGACGGTAACTTAAATTGTTGCCAGCTTGAGGCAAGACAAGGGAATCATCTAGTTAGGG
GTAACCATTAATTTATTTTATAAAGAAAGGAAATGCTGAAAGTCGTATTAGTACTGAGTTTAGTTGGAGAATTTAGATAAGTAAGTATCT
TTTAGGTAATTCTAAAATTAAAATCCTACCCACCTCACTACAGGGTTCCTCATGAAGGTGGGCGGCCACCTGGCCTGGGCCACCAGCAGC
ACATGGAGCAGACCTGAGGGGCCTGGCAGGGGGCACTGACCTCAGGATCCCCAGGTGGGGGTTTTAACCATGGGTGGGATCTCAGCTTCT
GCGCATACACTGACAATCTCACCTGTTCCTCAGTGTACTCCTCTGAAAAGAAGAAAGGATAATATTTATCCAATCTGTGTTCTCCTGAGC
TCCATCCTAGGGGTTTTTAATTTAACCAACAGCCATGTTGACAAAAGCCAACAATAAGCATGTCTTATTCTAGCCCTGATCCCAACACTG
AAAGCGAAGTACTTTATAAAGAAGCCAGCAATTATGAGGGTTTCTTTATGTTAGTAGGGGAAAAAATGGTAATAAAAGTACCAGTGTAGC
AAGTGAAGACCAAATTTATAGCACTGTGCATTAGATAGCAAAATCAGGTTCTTAACAATGAAAAGTAAACCTCAAGTTTCTAAATCCATA
TGCAGATGGTTAGGCTGTCCCTCTCTTAGCAAATCTCTCAGCCTCCTTCTTTCCCAAGTGCCAAGGATCCCTGGAGTAAAGCTCTGGGGT
CTGTGCTCTCTTTCTGTGAGGGGAAGGCTGCGGCCCTATTTGCCCCTCTCTAGCAAACACCCCCACCACCCTGCCGCTTCCTGTGGTTAT
TGAGCCAGCTAGGAGTTACTCATGGACTCTAACCTGGTTTTAGTCCCATGTACATCGTTGTTTTAGGTTTCATACTGAAGAGCCAATGGT
TTATGTGGTTTTATTCTGTCTTAAATATAAGTTTCAAGGAAGGGAAAACAAAAGTGATAAAATGATAGAACAGTCTAGAGGCCACTGTAA
AGTCACCGCCACTTTACGTGTATGTCAGTCTTGGTGTTCTTGTATGAGTAAAATGGATGTAAAATCATAAAATCACAGTGAATGTTTCAG
GCTACACTGGAAAAAGTATGCACTTAGAATTAAAGGAAATTGTATAATTCACCAAGATTTCTTTGTGTAGATCAGGGGTTGGCAACTATG
ACCCACAGGCTAAGACTGGTCAGCGGTCTGGTTTTTCACAGCCATGAGCTAAGTTACCTTTTTAAAGGGTTATATAAGTAATTACATCAT
ATTTTTGATTTTGCCTTTGGCCCACACCACATAAAATATTCAATACCTGGCCTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCAC
CCAGGATAGAGTGCACTGGTGCGATTTTGGCTCACTGCAACCTCTTCCTCCTGGGTTCAAGCAATTCTCCCTGCCTCAGCCTCTAAGTAG
CTGGGACTACAGGCACCCACTACCATGCCTTGCTAATTTTTGTATTTTTAATAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCG
AACTCCTGACCTCAGGGGATCCGCCCGCCTTGGCCTCCCAAACTGCTGGGATTACAGGTGAGCCACTGCGCCCAGCCAATACCTGGCCTT
TTAAGAAGTTTGCTGACTCCTGGTATGGATGACAGAAAATGGAATAACGTTTTGTTTCTCCAGTCTAGGAAAAGCAAGTCAGGTAGTGGA
TAGACTGACTGGCGTCCGGGGAGCCCAGGGTATGTGAGGGCCACGTGGATGGAAGCAAATGCCTCCTGCATAGCCCTTGGCTCTTTGTCC
CACTTGGGAGGAGTCCATGGATGTAATATTTACAAAACAATTTTTTCCTTACCATTTGCAGAAAGCATTGCATATATTTCCTTTTAGCTC
AGGAAACTGGCATGCCCCACCCTCTGCTACTCCATCAGATGTAAATACAATGACTATAAGCCGTACAACTCCCCTCTCTTAGAAACCTCA
GCAGGACCACAGAGCAAGGGAGTCAAAGCTTTCTTAATTCTCTCCAGTAAATGACTCAACTAATTTGATTTTTTTAATTAAGTCAAAATA
TCAAGAGAAAAATTGCTACTAAAACTTACATTTTGATCCACACTGATGTGCAACACAAAATGAAAGTTTTCACCTCCATTCCATTTTTTA
AAAATTCACGGTCCACACTGAAACTTGCTGGGTTTTAGCAGGAGACAAAGGTGTCACCCACGCTGTCCTCATCCTGCTCTCTCTGTCCCA
GTGACGCTCCAGCATATGATCACTGCAGCCGGTCCCTGGCCCGTGCCGATTCTGCCACCTCCCAGCCACACACATTTGCAGACCCACAAG
AAGAACTGTAGCCTTGATAATTTCAGTTCAGGCTGGAAAAATGCCATGCAATAATCTGGTTTGCTTTCAGTAAGTAGGCAACAAGTGAAA
ACTGTATAATTTTCATCACCTATTCTGCTGTTCTATCTAAAATGAGTGTACCTGTGGTTTGTGAACTGGGCCCTTGTTTGTGCCAGATCC
TTCAAAGATGTTCCCTGTCAGGACACCTGTGGCCCTGCCCCTCCTCAGACACCTTCCCACTGGCATTCACGTTCCTTATATGCAGTGTTA
GCCATCTTTGGCCTACGTGGACTTTTTTTGTAAATTACACCATTTCCAGACATTAAACTTTTTATATTATGAAATTTACCATGTAAAAAG
AACTTCATATTTTTATTGAGATTGCTAAGGCACTTGGCCTTCCTCCTTTGTGATTTTCAGTGTCTATTAAAGCATGAGTTCCCTCAGTTT

>90681_90681_1_THOC5-TTC28_THOC5_chr22_29945041_ENST00000397872_TTC28_chr22_28702631_ENST00000397906_length(amino acids)=2430AA_BP=2
MWCSALFKITYASSEATVPGHLHHLPQWNASCVKAHNNPCGGTTMSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQAYFRQGVALQYLGR
HADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLK
LRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLG
HVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFD
KAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHL
CIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQ
SEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLG
LAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYD
KALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQL
AMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELG
EAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYG
NLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASG
NLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVT
IDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSR
ACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLI
APMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKL
PSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPE
SLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHA
FYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDVKLNSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQR
NAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISR
AVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDST
ELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYL
QRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSP
FQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASET
SAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISK
SPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDV
LSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLRLPSGNGYKFLSPGRFFPSSKC

--------------------------------------------------------------
>90681_90681_2_THOC5-TTC28_THOC5_chr22_29945041_ENST00000490103_TTC28_chr22_28702631_ENST00000397906_length(transcript)=11489nt_BP=219nt
GCTTCCGGTCGGCCGCCCCTTCCTTACTTCCGGTTCTCTATGGTGCGCGGGCAAGCTTTGCTCCGCCTCCGGCAGTGGCTTACTCCCGGT
GCCAGGTTCTTGGAGCTGTGAGGAGGAACAACCATGTCATCAGAATCGAGCAAAAAACGGAAGCCCAAAGTGATCCGAAGCGATGGAGCC
CCAGCTGAAGGAAAGCGGAATCGATCTGACACCGAGCAGGCATACTTCCGACAGGGTGTTGCCCTCCAGTACCTTGGACGTCATGCCGAT
GCCCTGGCAGCCTTTGCATCTGGACTGGCTCAAGACCCCAAGAGTCTCCAGCTTCTGGTGGGGATGGTGGAAGCCGCCATGAAATCTCCC
ATGAGAGACTCCCTCGAGCCCACTTATCAGCAGCTTCAGAAAATGAAACTGGACAAGAGTCCCTTTGTGGTCGTGTCTGTGGTTGGGCAG
GAACTCCTGACAGCTGGCCATCATGGGGCCTCTGTGGTTGTCTTAGAAGCCGCACTGAAGATTGGCACCTGCAGCCTCAAACTGAGAGGT
TCTGTTTTCTCTGCCCTGAGCAGTGCTTACTGGTCTCTTGGAAATACAGAGAAGAGCACCGGATATATGCAGCAGGACTTGGATGTAGCC
AAGACCTTAGGTGACCAGACAGGAGAATGCCGAGCTCATGGGAATCTGGGCTCTGCATTCTTCTCCAAAGGAAATTACCGGGAGGCTCTC
ACTAACCACAGGCATCAGTTGGTACTCGCCATGAAACTCAAAGATCGAGAGGCAGCTTCATCAGCCTTGAGCAGTCTGGGCCACGTGTAC
ACAGCCATTGGAGACTACCCCAATGCACTGGCCAGTCACAAACAGTGTGTTCTTCTTGCCAAGCAATCCAAAGATGAACTTTCTGAAGCC
CGAGAACTTGGCAACATGGGAGCTGTGTATATTGCCATGGGTGACTTTGAGAATGCTGTGCAGTGCCATGAGCAGCATCTGAAGATAGCC
AAGGACCTGGGGAACAAGCGAGAAGAGGCCCGGGCTTATAGCAACCTGGGCAGTGCCTATCACTACCGGAGGAACTTTGACAAGGCCATG
TCTTACCATAACTATGTCCTGGAGCTGGCACAGGAGTTGATGGAGAAGGCTATTGAGATGCGGGCCTATGCTGGACTAGGCCATGCTGCC
AGGTGCATGCAGGATTTGGAGAGAGCTAAACAATACCATGAGCAGCAGCTGGGCATTGCTGAGGATCTCAAGGACCGGGCTGCAGAGGGG
CGAGCATCCTCCAATCTAGGAATCATACACCAGATGAAAGGTGATTATGACACTGCACTGAAACTCCACAAGACCCACCTGTGCATTGCC
CAGGAGCTGAGTGATTATGCTGCCCAGGGCCGTGCCTATGGGAATATGGGCAATGCCTACAATGCCCTGGGCATGTACGACCAGGCGGTC
AAATACCATCGGCAGGAGCTGCAGATCTCCATGGAAGTGAATGACCGCGCCTCACAGGCCTCCACACATGGGAACCTTGCCGTGGCCTAC
CAGGCCCTGGGTGCCCATGACCGGGCCCTGCAACACTATCAGAACCACTTGAACATCGCCCGGGAGCTACGAGACATCCAGAGCGAGGCC
CGGGCCCTCAGCAACCTGGGCAATTTCCACTGCTCTCGGGGAGAGTATGTCCAGGCTGCCCCCTATTATGAACAGTACCTCCGGCTTGCT
CCCGACCTTCAAGACATGGAAGGAGAAGGGAAGGTCTGCCACAATCTTGGCTATGCCCATTACTGCCTTGGAAACTATCAGGAGGCAGTG
AAGTACTACGAACAGGATCTGGCACTGGCTAAAGACCTTCACGACAAGTTGAGCCAAGCAAAAGCCTACTGCAACTTGGGCCTAGCATTC
AAGGCTCTGCTGAATTTCAGTAAAGCTGAAGAGTGTCAGAAGTACCTACTGTCCCTAGCCCAGTCTCTGAATAATTCCCAGGCTAAATTT
CGAGCCCTAGGAAACCTGGGCGATATATTCATCTGTAAAAAAGATATAAATGGTGCAATAAAATTCTATGAGCAGCAACTGGGCTTAGCT
CACCAGGTAAAGGACAGAAGATTAGAAGCCAGTGCATATGCAGCCCTGGGCACTGCATACCGAATGATCCAGAAGTATGACAAGGCCCTG
GGTTATCACACACAGGAACTGGAGGTATATCAGGAGCTGAGTGACTTGCCAGGGGAGTGCAGAGCTCATGGGCACCTGGCTGCTGTCTAC
ATGGCCCTTGGGAAATACACAATGGCATTCAAGTGTTATGAAGAGCAACTGGATCTAGGGCAAAAGCTGAAGGATCCGAGTCTGGAAGCC
CAGGTCTATGGCAACATGGGCATCACAAAGATGAACATGAATGTGATGGAAGAAGCCATTGGCTACTTTGAGCAGCAATTGGCCATGCTG
CAGCAGCTAAGTGGAAATGAGTCTGTGCTCGACAGGGGCCGGGCCTATGGCAACCTGGGGGATTGCTACGAAGCCCTGGGTGACTATGAG
GAAGCTATCAAATACTATGAACAATATTTATCTGTCGCGCAGAGTCTGAATCGCATGCAAGACCAAGCCAAGGCTTACCGGGGCCTGGGA
AATGGACACAGGGCAATGGGGAGCTTGCAGCAAGCCCTTGTGTGCTTTGAAAAGAGGCTCGTGGTTGCTCATGAACTTGGAGAGGCCTTC
AATAAAGCCCAGGCCTATGGAGAGCTGGGAAGTCTGCACAGCCAATTAGGGAATTACGAACAAGCCATTTCCTGCCTTGAACGCCAGCTG
AACATTGCTAGAGATATGAAAGACCGAGCCCTGGAGAGTGACGCAGCCTGTGGCCTGGGGGGCGTTTACCAGCAGATGGGGGAGTATGAC
ACAGCCCTGCAGTACCACCAGCTTGATCTACAGATAGCAGAGGAAACCAACAACCCCACGTGCCAGGGCCGAGCCTATGGGAACCTGGGC
CTGACTTATGAATCCCTGGGCACCTTCGAGAGGGCTGTGGTCTATCAAGAACAGCACTTGAGCATTGCTGCACAGATGAATGACTTGGCG
GCCAAGACGGTGTCATATAGTAGCCTTGGAAGGACCCATCATGCCTTGCAGAACTATTCCCAAGCAGTCATGTACTTACAGGAAGGTTTA
AGGTTAGCTGAGCAACTGGGCCGAAGAGAAGATGAGGCAAAAATTCGCCATGGCCTTGGCCTCTCCCTTTGGGCTAGTGGAAACTTGGAG
GAGGCCCAACACCAGCTTTATAGGGCATCAGCCTTGTTTGAAACAATCCGACATGAGGCACAGCTGAGCACGGACTACAAACTCTCCCTC
TTTGACCTGCAGACATCATCCTACCAGGCCTTGCAGCGGGTGCTCGTCAGCCTAGGCCATCATGATGAAGCCCTGGCTGTGGCAGAAAGG
GGACGGACAAGGGCATTTGCTGATCTTCTGGTGGAACGACAAACAGGACAACAAGACTCCGACCCCTACTCCCCAGTCACTATTGATCAG
ATCTTAGAGATGGTAAATGGCCAGAGGGGACTAGTGCTTTACTATTCCCTGGCTGCAGGCTATCTGTATAGCTGGCTGCTGGCTCCTGGG
GCAGGAATTGTGAAGTTTCATGAACACTACCTGGGTGAGAACACAGTGGAAAACTCAAGTGACTTCCAGGCCAGCAGCAGTGTAACCCTT
CCAACAGCAACCGGCTCAGCCCTGGAGCAGCACATTGCCAGTGTCCGGGAGGCCCTGGGGGTGGAGTCTCACTACTCAAGGGCCTGTGCC
AGCAGTGAGACAGAGAGTGAAGCGGGAGACATCATGGACCAGCAATTTGAAGAGATGAACAACAAACTCAACTCGGTCACTGACCCCACT
GGCTTTCTGCGGATGGTTCGCCGCAATAACCTGTTTAACAGGAGCTGCCAGAGCATGACGAGCCTGTTCAGTAACACTGTGTCACCGACC
CAGGACGGGACCTCCTCTCTTCCCAGGAGGCAGAGCTCGTTTGCCAAGCCCCCGCTCCGTGCCCTGTATGACCTGCTCATCGCGCCCATG
GAAGGGGGCCTGATGCACTCCAGCGGCCCCGTGGGCCGGCACCGGCAGCTCATCCTGGTTCTGGAGGGGGAGCTCTACCTCATTCCTTTC
GCCCTCCTGAAGGGAAGCTCCTCCAATGAGTACCTCTACGAGCGCTTCGGCCTCCTTGCTGTCCCTTCCATCCGCTCCCTCAGCGTGCAG
TCCAAGTCTCACTTACGGAAGAACCCGCCCACATACTCCAGCTCCACATCCATGGCGGCTGTCATCGGCAACCCCAAGCTACCATCGGCC
GTGATGGACAGGTGGCTGTGGGGGCCCATGCCATCGGCCGAGGAAGAGGCCTACATGGTGTCCGAGCTGCTGGGCTGCCAGCCCCTAGTG
GGCAGTGTGGCCACCAAGGAGAGGGTCATGAGTGCCCTGACCCAGGCTGAATGCGTCCACTTTGCCACCCACATCTCCTGGAAGCTGTCG
GCCTTGGTCCTCACGCCCAGCATGGACGGCAACCCTGCCAGCAGCAAGAGCTCCTTCGGCCACCCCTACACGATCCCTGAGTCCTTGCGG
GTGCAGGACGATGCCAGTGATGGGGAGAGCATCTCGGACTGCCCGCCCCTGCAGGAGCTGCTGCTTACTGCCGCCGACGTCCTGGACCTG
CAGCTGCCTGTGAAGCTGGTGGTGCTTGGCTCCTCCCAGGAGTCCAACAGCAAAGTCACAGCCGACGGGGTCATCGCGCTGACAAGGGCC
TTCCTGGCTGCCGGCGCTCAGTGTGTCCTCGTGTCTCTGTGGCCTGTGCCAGTGGCTGCTTCTAAGATGTTCATCCATGCCTTCTACTCA
TCCCTGCTGAACGGCCTGAAAGCCAGCGCCGCCCTGGGGGAGGCCATGAAGGTGGTGCAGAGCAGCAAGGCCTTCTCGCACCCCTCCAAC
TGGGCAGGGTTCATGCTCATCGGGAGTGACGTTAAGCTGAACAGCCCCTCATCACTCATCGGCCAGGCCCTCACAGAGATCCTGCAGCAC
CCGGAGCGTGCGCGGGACGCCCTGCGAGTGCTGCTGCACCTGGTGGAGAAATCCCTGCAGCGCATCCAGAATGGGCAGCGCAATGCCATG
TACACATCCCAGCAGAGTGTGGAGAACAAAGTGGGCGGCATCCCTGGCTGGCAGGCCCTCCTCACCGCTGTGGGCTTCCGGCTGGACCCC
CCAACCAGTGGCCTGCCAGCGGCTGTCTTCTTCCCAACCTCCGACCCGGGCGACCGGCTCCAGCAGTGCAGCAGCACACTCCAGTCCCTG
CTGGGTCTGCCCAATCCTGCCCTCCAAGCCCTTTGCAAACTCATCACTGCCTCCGAGACGGGCGAGCAGCTCATCAGCCGGGCTGTTAAA
AATATGGTTGGAATGCTCCACCAGGTGCTGGTTCAGCTCCAGGCTGGCGAGAAGGAGCAGGACTTGGCATCAGCTCCCATTCAGGTCTCC
ATCAGCGTCCAGCTGTGGCGGCTCCCGGGATGCCACGAGTTCCTGGCAGCTCTAGGTTTTGATCTCTGTGAAGTTGGTCAGGAGGAAGTA
ATCCTGAAAACCGGGAAGCAAGCTAATCGACGGACTGTGCACTTCGCGCTCCAGTCCCTGCTGTCTCTGTTTGATTCTACTGAGCTACCC
AAGCGCCTCAGCCTTGACAGCTCCTCCTCCCTCGAGTCTCTTGCTTCTGCTCAGTCTGTTTCCAACGCCCTGCCCTTGGGTTACCAGCAA
CCCCCCTTCTCTCCCACCGGTGCGGACAGCATCGCCTCAGATGCCATCTCTGTGTACAGTCTGAGCTCCATTGCCTCCTCAATGAGCTTT
GTCTCCAAACCCGAGGGTGGATCAGAGGGTGGAGGCCCCGGAGGACGGCAGGACCATGACCGGTCCAAGAACGCTTACCTGCAGAGATCC
ACCCTGCCTAGGAGCCAGCTGCCTCCCCAGACCCGCCCTGCAGGCAACAAAGATGAAGAAGAATATGAAGGGTTTTCTATCATCAGTAAC
GAGCCCTTGGCGACCTACCAAGAAAACCGAAACACATGCTTCTCACCAGACCACAAACAACCCCAACCTGGGACAGCCGGAGGCATGAGA
GTCTCGGTGAGCTCCAAAGGGAGCATCAGCACTCCAAATTCTCCAGTGAAAATGACTCTGATTCCCAGCCCCAACTCACCCTTCCAAAAG
GTGGGAAAACTAGCAAGCTCAGATACAGGAGAATCAGACCAGTCTAGCACAGAAACGGACAGTACCGTGAAATCCCAAGAAGAAAGCAAC
CCAAAACTGGATCCACAAGAGTTAGCCCAGAAAATTCTGGAGGAGACACAGAGTCATCTCATTGCGGTGGAGCGTCTTCAGAGGAGCGGC
GGCCAGGTGAGCAAGAGTAATAACCCTGAAGACGGCGTTCAGGCGCCCAGCAGCACTGCTGTCTTCAGAGCGTCAGAAACCAGTGCGTTC
AGCAGGCCTGTTCTCTCCCATCAGAAGAGTCAGCCATCACCAGTCACTGTTAAACCAAAGCCCCCAGCCAGGAGCTCCTCCCTGCCCAAG
GTGAGTTCCGGATATAGCAGCCCCACCACCTCAGAGATGTCCATCAAAGACAGCCCGAGCCAGCACAGTGGCCGGCCATCGCCCGGCTGC
GACTCACAGACTTCCCAGCTGGACCAGCCTCTCTTTAAACTGAAGTACCCCAGCTCTCCTTACAGCGCTCACATTTCCAAATCACCAAGG
AACATGTCCCCAAGCTCCGGCCACCAGTCTCCTGCTGGCAGTGCACCCTCCCCAGCTCTCTCCTACTCCTCAGCTGGATCTGCTCGCTCA
AGTCCAGCAGACGCTCCCGACATAGACAAACTGAAAATGGCAGCCATTGATGAAAAGGTGCAGGCTGTCCATAACCTGAAGATGTTCTGG
CAGAGCACACCCCAGCATTCCACAGGGCCAATGAAGATCTTCCGGGGGGCTCCTGGCACGATGACTTCCAAAAGGGATGTCCTCAGTCTG
TTGAATTTGTCACCACGGCACAATAAGAAGGAGGAGGGAGTGGATAAGCTTGAACTGAAGGAGCTGTCCCTGCAGCAGCATGACGGAGCT
CCACCGAAAGCCCCTCCCAACGGACACTGGCGCACCGAGACCACCTCGCTGGGCTCACTGCCGCTGCCCGCCGGCCCTCCCGCCACAGCC
CCCGCGCGCCCTTTGAGGCTTCCTTCTGGAAATGGCTACAAGTTCCTGTCTCCAGGAAGATTTTTCCCTTCTTCCAAATGCTAAAGCATC
TTTTATACCCACTGACTCTGAGCAGCCTGCAGATGGGGGCCTGGCGTTTGCTTCAGCCCTTCCCTGAGTGCAGTCCCCCCACAGCCACCA
GCACCCTCATGATGCTGTGCTCTGCAGGCGAGGGGCACCACCACGTCCAAAGGCTGCCACACACACTGGTGGCTTTTCTGGGCCACATTC
ACCAAAAGCCAGGACTTCTGTGGGGCTGGTACAGGAGGCTCATGGAATTTCCTACACACTTCACCAAATGTTTGTTTACCTTTGAACTCC
CTGCTTCTCATCTTTGATATGATTCTTCACCAGGATTTTGTACAAAAATGATCATGGTTCTGGGGTGGGGAGAGGAAAGGGAGCACATAT
TTTGCTAAGAGGTATATATGCAGTACCTTTTATACACAGAAATACAAATAGAGCTTTTTCTAAGGCTTTCGGTTGCTGGTTGGGGGTGGG
ATATATGAAATTTCAGTTGAATTCTACAGGAAAGTGTTATATTAGCCAAAAACAGAAAAATGGTTTTTAAAATGCCAATGATTTGTAATT
AAATTGTAGCAATTTTGGTCTCATGATAGTGTAATATCTCAGCAACAATGCAATAATTCACATTGAAACAGCGCTTCCATTCTGAACTCT
GCTCTGCAAATGTCTTTTGGGTCCCGCTGTCAACCAAACTTGAATTTTCTTAAAAAAAAAATTATGTAACTCTTATCCAGGCATTTTAGA
ACTATGCAATTGTGATTTAAAATGCAACTTTGTGCTTTTAAAACATTATTGACCTTTTTTGTATATGGATAAACAACTTGGTTTTATTAT
CAATAGTACTTTGCATTTATAGCTATTATTTTTAAAAGCTCAAAAAGTTTTTTAAAATGTCAAATTTTGAATAGTCATCAATAAGTAATT
ATCAAGTTTGGAAGGAAAGGTTGAAATGACTCCGTTTCCTTATAAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTTCCA
TGGCTAACTAGATTTAACCAGAATCCCGCCTTCCAGGCTCCTGTTCCCTTTTATTAGCTGCTGAATTTTATTCCCTTTTCCCAACTCCAG
GTCCCTCAGTTGTCTTATATCTAAATCCTTTGCCAGGTCCCCACAATCCCAGCACCTGCCTCTGTGAGCTGCCCCCAGGCCCTCACCTTG
GCCCTGGCCAGCCTCCTGTGCTCCTGCTGTCTGAAGGACTGGCCCCTCCCCCACTGCTGAAGCCACACGTACAGATCCTAAGCAACAGGG
CCTTTTGCTGGGACGTATGCCTGGATTATGGCCAACCGGGAAGAGAGAGATGTATCTTAAAAAGTGGAGGTGGACTTCTCCTACAGCTCT
GACGGTAACTTAAATTGTTGCCAGCTTGAGGCAAGACAAGGGAATCATCTAGTTAGGGGTAACCATTAATTTATTTTATAAAGAAAGGAA
ATGCTGAAAGTCGTATTAGTACTGAGTTTAGTTGGAGAATTTAGATAAGTAAGTATCTTTTAGGTAATTCTAAAATTAAAATCCTACCCA
CCTCACTACAGGGTTCCTCATGAAGGTGGGCGGCCACCTGGCCTGGGCCACCAGCAGCACATGGAGCAGACCTGAGGGGCCTGGCAGGGG
GCACTGACCTCAGGATCCCCAGGTGGGGGTTTTAACCATGGGTGGGATCTCAGCTTCTGCGCATACACTGACAATCTCACCTGTTCCTCA
GTGTACTCCTCTGAAAAGAAGAAAGGATAATATTTATCCAATCTGTGTTCTCCTGAGCTCCATCCTAGGGGTTTTTAATTTAACCAACAG
CCATGTTGACAAAAGCCAACAATAAGCATGTCTTATTCTAGCCCTGATCCCAACACTGAAAGCGAAGTACTTTATAAAGAAGCCAGCAAT
TATGAGGGTTTCTTTATGTTAGTAGGGGAAAAAATGGTAATAAAAGTACCAGTGTAGCAAGTGAAGACCAAATTTATAGCACTGTGCATT
AGATAGCAAAATCAGGTTCTTAACAATGAAAAGTAAACCTCAAGTTTCTAAATCCATATGCAGATGGTTAGGCTGTCCCTCTCTTAGCAA
ATCTCTCAGCCTCCTTCTTTCCCAAGTGCCAAGGATCCCTGGAGTAAAGCTCTGGGGTCTGTGCTCTCTTTCTGTGAGGGGAAGGCTGCG
GCCCTATTTGCCCCTCTCTAGCAAACACCCCCACCACCCTGCCGCTTCCTGTGGTTATTGAGCCAGCTAGGAGTTACTCATGGACTCTAA
CCTGGTTTTAGTCCCATGTACATCGTTGTTTTAGGTTTCATACTGAAGAGCCAATGGTTTATGTGGTTTTATTCTGTCTTAAATATAAGT
TTCAAGGAAGGGAAAACAAAAGTGATAAAATGATAGAACAGTCTAGAGGCCACTGTAAAGTCACCGCCACTTTACGTGTATGTCAGTCTT
GGTGTTCTTGTATGAGTAAAATGGATGTAAAATCATAAAATCACAGTGAATGTTTCAGGCTACACTGGAAAAAGTATGCACTTAGAATTA
AAGGAAATTGTATAATTCACCAAGATTTCTTTGTGTAGATCAGGGGTTGGCAACTATGACCCACAGGCTAAGACTGGTCAGCGGTCTGGT
TTTTCACAGCCATGAGCTAAGTTACCTTTTTAAAGGGTTATATAAGTAATTACATCATATTTTTGATTTTGCCTTTGGCCCACACCACAT
AAAATATTCAATACCTGGCCTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGATAGAGTGCACTGGTGCGATTTTGGCT
CACTGCAACCTCTTCCTCCTGGGTTCAAGCAATTCTCCCTGCCTCAGCCTCTAAGTAGCTGGGACTACAGGCACCCACTACCATGCCTTG
CTAATTTTTGTATTTTTAATAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGGGATCCGCCCGCCTTG
GCCTCCCAAACTGCTGGGATTACAGGTGAGCCACTGCGCCCAGCCAATACCTGGCCTTTTAAGAAGTTTGCTGACTCCTGGTATGGATGA
CAGAAAATGGAATAACGTTTTGTTTCTCCAGTCTAGGAAAAGCAAGTCAGGTAGTGGATAGACTGACTGGCGTCCGGGGAGCCCAGGGTA
TGTGAGGGCCACGTGGATGGAAGCAAATGCCTCCTGCATAGCCCTTGGCTCTTTGTCCCACTTGGGAGGAGTCCATGGATGTAATATTTA
CAAAACAATTTTTTCCTTACCATTTGCAGAAAGCATTGCATATATTTCCTTTTAGCTCAGGAAACTGGCATGCCCCACCCTCTGCTACTC
CATCAGATGTAAATACAATGACTATAAGCCGTACAACTCCCCTCTCTTAGAAACCTCAGCAGGACCACAGAGCAAGGGAGTCAAAGCTTT
CTTAATTCTCTCCAGTAAATGACTCAACTAATTTGATTTTTTTAATTAAGTCAAAATATCAAGAGAAAAATTGCTACTAAAACTTACATT
TTGATCCACACTGATGTGCAACACAAAATGAAAGTTTTCACCTCCATTCCATTTTTTAAAAATTCACGGTCCACACTGAAACTTGCTGGG
TTTTAGCAGGAGACAAAGGTGTCACCCACGCTGTCCTCATCCTGCTCTCTCTGTCCCAGTGACGCTCCAGCATATGATCACTGCAGCCGG
TCCCTGGCCCGTGCCGATTCTGCCACCTCCCAGCCACACACATTTGCAGACCCACAAGAAGAACTGTAGCCTTGATAATTTCAGTTCAGG
CTGGAAAAATGCCATGCAATAATCTGGTTTGCTTTCAGTAAGTAGGCAACAAGTGAAAACTGTATAATTTTCATCACCTATTCTGCTGTT
CTATCTAAAATGAGTGTACCTGTGGTTTGTGAACTGGGCCCTTGTTTGTGCCAGATCCTTCAAAGATGTTCCCTGTCAGGACACCTGTGG
CCCTGCCCCTCCTCAGACACCTTCCCACTGGCATTCACGTTCCTTATATGCAGTGTTAGCCATCTTTGGCCTACGTGGACTTTTTTTGTA
AATTACACCATTTCCAGACATTAAACTTTTTATATTATGAAATTTACCATGTAAAAAGAACTTCATATTTTTATTGAGATTGCTAAGGCA

>90681_90681_2_THOC5-TTC28_THOC5_chr22_29945041_ENST00000490103_TTC28_chr22_28702631_ENST00000397906_length(amino acids)=2386AA_BP=0
MSSESSKKRKPKVIRSDGAPAEGKRNRSDTEQAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQ
LQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECR
AHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYI
AMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQ
YHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISM
EVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGK
VCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIFI
CKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFK
CYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLS
VAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRAL
ESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGR
THHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIRHEAQLSTDYKLSLFDLQTSSYQAL
QRVLVSLGHHDEALAVAERGRTRAFADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKFHEHYL
GENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETESEAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNL
FNRSCQSMTSLFSNTVSPTQDGTSSLPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGSSSNEY
LYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWLWGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMS
ALTQAECVHFATHISWKLSALVLTPSMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKLVVLGS
SQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGLKASAALGEAMKVVQSSKAFSHPSNWAGFMLIGSDV
KLNSPSSLIGQALTEILQHPERARDALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLPAAVFF
PTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGMLHQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGC
HEFLAALGFDLCEVGQEEVILKTGKQANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPTGADSI
ASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQLPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRN
TCFSPDHKQPQPGTAGGMRVSVSSKGSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQELAQK
ILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLSHQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTS
EMSIKDSPSQHSGRPSPGCDSQTSQLDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKL
KMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWR

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Fusion Gene PPI Analysis for THOC5-TTC28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneTHOC5chr22:29945041chr22:28702631ENST00000397871-2202_14432.0684.0CSF1R
HgeneTHOC5chr22:29945041chr22:28702631ENST00000397872-3212_14432.0684.0CSF1R
HgeneTHOC5chr22:29945041chr22:28702631ENST00000397873-3212_14432.0684.0CSF1R
HgeneTHOC5chr22:29945041chr22:28702631ENST00000490103-2202_14432.0684.0CSF1R
HgeneTHOC5chr22:29945041chr22:28702631ENST00000397871-2202_19932.0684.0THOC7
HgeneTHOC5chr22:29945041chr22:28702631ENST00000397872-3212_19932.0684.0THOC7
HgeneTHOC5chr22:29945041chr22:28702631ENST00000397873-3212_19932.0684.0THOC7
HgeneTHOC5chr22:29945041chr22:28702631ENST00000490103-2202_19932.0684.0THOC7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THOC5-TTC28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THOC5-TTC28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource