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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAZ2B-WDSUB1 (FusionGDB2 ID:9072)

Fusion Gene Summary for BAZ2B-WDSUB1

check button Fusion gene summary
Fusion gene informationFusion gene name: BAZ2B-WDSUB1
Fusion gene ID: 9072
HgeneTgene
Gene symbol

BAZ2B

WDSUB1

Gene ID

29994

151525

Gene namebromodomain adjacent to zinc finger domain 2BWD repeat, sterile alpha motif and U-box domain containing 1
SynonymsWALp4UBOX6|WDSAM1
Cytomap

2q24.2

2q24.2

Type of geneprotein-codingprotein-coding
Descriptionbromodomain adjacent to zinc finger domain protein 2BWD repeat, SAM and U-box domain-containing protein 1
Modification date2020031320200313
UniProtAcc

Q9UIF8

.
Ensembl transtripts involved in fusion geneENST00000343439, ENST00000355831, 
ENST00000392782, ENST00000392783, 
ENST00000483316, 		ENST00000358147, 
ENST00000392796, ENST00000409124, 
ENST00000409990, ENST00000359774, 
Fusion gene scores* DoF score19 X 14 X 12=31923 X 3 X 3=27
# samples 223
** MAII scorelog2(22/3192*10)=-3.85888522269769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BAZ2B [Title/Abstract] AND WDSUB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWDSUB1(160136272)-BAZ2B(160189197), # samples:2
BAZ2B(160335086)-WDSUB1(160116354), # samples:1
Anticipated loss of major functional domain due to fusion event.WDSUB1-BAZ2B seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
WDSUB1-BAZ2B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
WDSUB1-BAZ2B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
WDSUB1-BAZ2B seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BAZ2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WDSUB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5K0-01ABAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-


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Fusion Gene ORF analysis for BAZ2B-WDSUB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343439ENST00000358147BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000343439ENST00000392796BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000343439ENST00000409124BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000343439ENST00000409990BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000355831ENST00000358147BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000355831ENST00000392796BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000355831ENST00000409124BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000355831ENST00000409990BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000392782ENST00000358147BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000392782ENST00000392796BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000392782ENST00000409124BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000392782ENST00000409990BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000392783ENST00000358147BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000392783ENST00000392796BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000392783ENST00000409124BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5CDS-intronENST00000392783ENST00000409990BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5UTR-3CDSENST00000483316ENST00000359774BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5UTR-intronENST00000483316ENST00000358147BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5UTR-intronENST00000483316ENST00000392796BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5UTR-intronENST00000483316ENST00000409124BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
5UTR-intronENST00000483316ENST00000409990BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
In-frameENST00000343439ENST00000359774BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
In-frameENST00000355831ENST00000359774BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
In-frameENST00000392782ENST00000359774BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-
In-frameENST00000392783ENST00000359774BAZ2Bchr2

160335086

-WDSUB1chr2

160116354

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355831BAZ2Bchr2160335086-ENST00000359774WDSUB1chr2160116354-13984974921157221
ENST00000343439BAZ2Bchr2160335086-ENST00000359774WDSUB1chr2160116354-13984974921157221
ENST00000392782BAZ2Bchr2160335086-ENST00000359774WDSUB1chr2160116354-14195185131178221
ENST00000392783BAZ2Bchr2160335086-ENST00000359774WDSUB1chr2160116354-15426416361301221

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355831ENST00000359774BAZ2Bchr2160335086-WDSUB1chr2160116354-0.002479610.9975204
ENST00000343439ENST00000359774BAZ2Bchr2160335086-WDSUB1chr2160116354-0.002479610.9975204
ENST00000392782ENST00000359774BAZ2Bchr2160335086-WDSUB1chr2160116354-0.0022052250.99779475
ENST00000392783ENST00000359774BAZ2Bchr2160335086-WDSUB1chr2160116354-0.0024760340.99752396

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Fusion Genomic Features for BAZ2B-WDSUB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BAZ2B-WDSUB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:160136272/chr2:160189197)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BAZ2B

Q9UIF8

.
FUNCTION: Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543). Involved in positively modulating the rate of age-related behavioral deterioration (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity). {ECO:0000250|UniProtKB:A2AUY4, ECO:0000303|PubMed:10662543}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000035814707332_3960385.0DomainSAM
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000035814707403_4760385.0DomainNote=U-box
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000359774411332_396256477.0DomainSAM
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000359774411403_476256477.0DomainNote=U-box
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000392796411332_396256477.0DomainSAM
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000392796411403_476256477.0DomainNote=U-box
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000409990411332_396256477.0DomainSAM
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000409990411403_476256477.0DomainNote=U-box
TgeneWDSUB1chr2:160335086chr2:160116354ENST000003581470710_470385.0RepeatNote=WD 1
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000035814707137_1760385.0RepeatNote=WD 4
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000035814707178_2280385.0RepeatNote=WD 5
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000035814707237_2760385.0RepeatNote=WD 6
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000035814707279_3180385.0RepeatNote=WD 7
TgeneWDSUB1chr2:160335086chr2:160116354ENST000003581470752_910385.0RepeatNote=WD 2
TgeneWDSUB1chr2:160335086chr2:160116354ENST000003581470795_1340385.0RepeatNote=WD 3
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000359774411279_318256477.0RepeatNote=WD 7
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000392796411279_318256477.0RepeatNote=WD 7
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000409990411279_318256477.0RepeatNote=WD 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-3361334_1375482069.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-336883_1061482069.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-3361334_1375482135.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-336883_1061482135.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-3361334_1375482133.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-336883_1061482133.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-3371334_1375482169.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-337883_1061482169.0Coiled coilOntology_term=ECO:0000255
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-3361296_1339482069.0Compositional biasNote=Asp-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-336149_265482069.0Compositional biasNote=Ser-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-336269_275482069.0Compositional biasNote=Poly-Glu
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-336595_666482069.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-336837_868482069.0Compositional biasNote=Arg-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-336902_1061482069.0Compositional biasNote=Lys-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-3361296_1339482135.0Compositional biasNote=Asp-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-336149_265482135.0Compositional biasNote=Ser-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-336269_275482135.0Compositional biasNote=Poly-Glu
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-336595_666482135.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-336837_868482135.0Compositional biasNote=Arg-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-336902_1061482135.0Compositional biasNote=Lys-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-3361296_1339482133.0Compositional biasNote=Asp-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-336149_265482133.0Compositional biasNote=Ser-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-336269_275482133.0Compositional biasNote=Poly-Glu
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-336595_666482133.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-336837_868482133.0Compositional biasNote=Arg-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-336902_1061482133.0Compositional biasNote=Lys-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-3371296_1339482169.0Compositional biasNote=Asp-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-337149_265482169.0Compositional biasNote=Ser-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-337269_275482169.0Compositional biasNote=Poly-Glu
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-337595_666482169.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-337837_868482169.0Compositional biasNote=Arg-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-337902_1061482169.0Compositional biasNote=Lys-rich
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-3361087_1152482069.0DomainDDT
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-3362077_2147482069.0DomainBromo
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-336739_810482069.0DomainMBD
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-3361087_1152482135.0DomainDDT
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-3362077_2147482135.0DomainBromo
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-336739_810482135.0DomainMBD
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-3361087_1152482133.0DomainDDT
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-3362077_2147482133.0DomainBromo
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-336739_810482133.0DomainMBD
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-3371087_1152482169.0DomainDDT
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-3372077_2147482169.0DomainBromo
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-337739_810482169.0DomainMBD
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000343439-3361931_1981482069.0Zinc fingerPHD-type
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000355831-3361931_1981482135.0Zinc fingerPHD-type
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392782-3361931_1981482133.0Zinc fingerPHD-type
HgeneBAZ2Bchr2:160335086chr2:160116354ENST00000392783-3371931_1981482169.0Zinc fingerPHD-type
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000035977441110_47256477.0RepeatNote=WD 1
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000359774411137_176256477.0RepeatNote=WD 4
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000359774411178_228256477.0RepeatNote=WD 5
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000359774411237_276256477.0RepeatNote=WD 6
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000035977441152_91256477.0RepeatNote=WD 2
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000035977441195_134256477.0RepeatNote=WD 3
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000039279641110_47256477.0RepeatNote=WD 1
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000392796411137_176256477.0RepeatNote=WD 4
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000392796411178_228256477.0RepeatNote=WD 5
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000392796411237_276256477.0RepeatNote=WD 6
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000039279641152_91256477.0RepeatNote=WD 2
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000039279641195_134256477.0RepeatNote=WD 3
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000040999041110_47256477.0RepeatNote=WD 1
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000409990411137_176256477.0RepeatNote=WD 4
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000409990411178_228256477.0RepeatNote=WD 5
TgeneWDSUB1chr2:160335086chr2:160116354ENST00000409990411237_276256477.0RepeatNote=WD 6
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000040999041152_91256477.0RepeatNote=WD 2
TgeneWDSUB1chr2:160335086chr2:160116354ENST0000040999041195_134256477.0RepeatNote=WD 3


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Fusion Gene Sequence for BAZ2B-WDSUB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>9072_9072_1_BAZ2B-WDSUB1_BAZ2B_chr2_160335086_ENST00000343439_WDSUB1_chr2_160116354_ENST00000359774_length(transcript)=1398nt_BP=497nt
ACTTGGTTCATGAAGCCTTCGCCTAGAAGTGAAGCTGCTGAACAAACCTTGAGAAGAATCATCTCCTGCTTCAATCTGCTGCTGGATAGG
AACTAATCAGAGAGAGAGAGGCGGAAGACGGAGAAGGAGGGAGTCGAAGGCTTTCCCGATCACAAATCTCACCTCCACTACAACTCTCTT
TATACTTTTCTTGCAGAAATAATAATAGAAATAAGGAGGTGGTGGGGTTTCCAAAAATCTTAACCTTCAACCATCTGGGGAAAAGGCAAA
AATCCCATCTACCGCAACTCTCAGTTCGAGAGTAAAGGTTTCCCAACAGTGATGTCACAAGATTGACCACATTGATCACAATATGGAGTC
TGGAGAACGGTTACCATCCTCAGCAGCCTCCTCTACTACACCAACTTCATCTTCGACACCTTCTGTGGCTTCAGTAGTTTCAAAAGGTGG
CCTTTCCACTGGAGTTGCTTCACTTAGCTCTACAATCAACCCATGTGGTCAGTGGATAAGTCTGTCATAGTATATGATACTAATACTGAG
AATATACTTCACACATTGACTCAGCACACCAGGTATGTCACAACTTGTGCTTTTGCACCTAATACCCTTTTACTTGCTACTGGTTCAATG
GACAAAACAGTGAACATCTGGCAATTTGACCTGGAAACACTTTGCCAAGCAAGGCGCACAGAACATCAGCTGAAGCAATTTACCGAAGAT
TGGTCAGAGGAGGATGTCTCAACATGGCTTTGTGCACAAGATTTAAAAGATCTTGTTGGTATTTTCAAGATGAATAACATTGATGGAAAA
GAACTGTTGAATCTTACAAAAGAAAGTCTGGCTGATGATTTGAAAATTGAATCTCTAGGACTGCGTAGTAAAGTGCTGAGGAAAATTGAA
GAGCTCAGGACCAAGGTTAAATCCCTTTCTTCAGGAATTCCTGATGAATTTATATGTCCAATAACTAGAGAACTTATGAAAGATCCGGTC
ATCGCATCAGATGGCTATTCATATGAAAAGGAAGCAATGGAAAATTGGATCAGCAAAAAGAAACGTACAAGTCCCATGACAAATCTTGTT
CTTCCTTCAGCGGTACTTACACCAAATAGGACTCTGAAAATGGCCATCAATAGATGGCTGGAGACACACCAAAAGTAAAATTGTTGATAT
TGTATTATTTATATTTTCAGTGATCTCATTTGAATGATTTATAGGTAAATACTAATCAGACATTATTAAAAGCAAAACAGGAAAAAGGTA
AACTTCTTAAATTTAGTTACCTATAAAAATTGTCAATTTTCATTCTTTAAAAAACACATGGACTTACTATAAAAGCCTTTTTGTACTAGT

>9072_9072_1_BAZ2B-WDSUB1_BAZ2B_chr2_160335086_ENST00000343439_WDSUB1_chr2_160116354_ENST00000359774_length(amino acids)=221AA_BP=2
MWSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQD
LKDLVGIFKMNNIDGKELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDPVIASDGYSYEKEAME

--------------------------------------------------------------
>9072_9072_2_BAZ2B-WDSUB1_BAZ2B_chr2_160335086_ENST00000355831_WDSUB1_chr2_160116354_ENST00000359774_length(transcript)=1398nt_BP=497nt
ACTTGGTTCATGAAGCCTTCGCCTAGAAGTGAAGCTGCTGAACAAACCTTGAGAAGAATCATCTCCTGCTTCAATCTGCTGCTGGATAGG
AACTAATCAGAGAGAGAGAGGCGGAAGACGGAGAAGGAGGGAGTCGAAGGCTTTCCCGATCACAAATCTCACCTCCACTACAACTCTCTT
TATACTTTTCTTGCAGAAATAATAATAGAAATAAGGAGGTGGTGGGGTTTCCAAAAATCTTAACCTTCAACCATCTGGGGAAAAGGCAAA
AATCCCATCTACCGCAACTCTCAGTTCGAGAGTAAAGGTTTCCCAACAGTGATGTCACAAGATTGACCACATTGATCACAATATGGAGTC
TGGAGAACGGTTACCATCCTCAGCAGCCTCCTCTACTACACCAACTTCATCTTCGACACCTTCTGTGGCTTCAGTAGTTTCAAAAGGTGG
CCTTTCCACTGGAGTTGCTTCACTTAGCTCTACAATCAACCCATGTGGTCAGTGGATAAGTCTGTCATAGTATATGATACTAATACTGAG
AATATACTTCACACATTGACTCAGCACACCAGGTATGTCACAACTTGTGCTTTTGCACCTAATACCCTTTTACTTGCTACTGGTTCAATG
GACAAAACAGTGAACATCTGGCAATTTGACCTGGAAACACTTTGCCAAGCAAGGCGCACAGAACATCAGCTGAAGCAATTTACCGAAGAT
TGGTCAGAGGAGGATGTCTCAACATGGCTTTGTGCACAAGATTTAAAAGATCTTGTTGGTATTTTCAAGATGAATAACATTGATGGAAAA
GAACTGTTGAATCTTACAAAAGAAAGTCTGGCTGATGATTTGAAAATTGAATCTCTAGGACTGCGTAGTAAAGTGCTGAGGAAAATTGAA
GAGCTCAGGACCAAGGTTAAATCCCTTTCTTCAGGAATTCCTGATGAATTTATATGTCCAATAACTAGAGAACTTATGAAAGATCCGGTC
ATCGCATCAGATGGCTATTCATATGAAAAGGAAGCAATGGAAAATTGGATCAGCAAAAAGAAACGTACAAGTCCCATGACAAATCTTGTT
CTTCCTTCAGCGGTACTTACACCAAATAGGACTCTGAAAATGGCCATCAATAGATGGCTGGAGACACACCAAAAGTAAAATTGTTGATAT
TGTATTATTTATATTTTCAGTGATCTCATTTGAATGATTTATAGGTAAATACTAATCAGACATTATTAAAAGCAAAACAGGAAAAAGGTA
AACTTCTTAAATTTAGTTACCTATAAAAATTGTCAATTTTCATTCTTTAAAAAACACATGGACTTACTATAAAAGCCTTTTTGTACTAGT

>9072_9072_2_BAZ2B-WDSUB1_BAZ2B_chr2_160335086_ENST00000355831_WDSUB1_chr2_160116354_ENST00000359774_length(amino acids)=221AA_BP=2
MWSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQD
LKDLVGIFKMNNIDGKELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDPVIASDGYSYEKEAME

--------------------------------------------------------------
>9072_9072_3_BAZ2B-WDSUB1_BAZ2B_chr2_160335086_ENST00000392782_WDSUB1_chr2_160116354_ENST00000359774_length(transcript)=1419nt_BP=518nt
GAAGCCTTGTTGGTTGACGTCACTTGGTTCATGAAGCCTTCGCCTAGAAGTGAAGCTGCTGAACAAACCTTGAGAAGAATCATCTCCTGC
TTCAATCTGCTGCTGGATAGGAACTAATCAGAGAGAGAGAGGCGGAAGACGGAGAAGGAGGGAGTCGAAGGCTTTCCCGATCACAAATCT
CACCTCCACTACAACTCTCTTTATACTTTTCTTGCAGAAATAATAATAGAAATAAGGAGGTGGTGGGGTTTCCAAAAATCTTAACCTTCA
ACCATCTGGGGAAAAGGCAAAAATCCCATCTACCGCAACTCTCAGTTCGAGAGTAAAGGTTTCCCAACAGTGATGTCACAAGATTGACCA
CATTGATCACAATATGGAGTCTGGAGAACGGTTACCATCCTCAGCAGCCTCCTCTACTACACCAACTTCATCTTCGACACCTTCTGTGGC
TTCAGTAGTTTCAAAAGGTGGCCTTTCCACTGGAGTTGCTTCACTTAGCTCTACAATCAACCCATGTGGTCAGTGGATAAGTCTGTCATA
GTATATGATACTAATACTGAGAATATACTTCACACATTGACTCAGCACACCAGGTATGTCACAACTTGTGCTTTTGCACCTAATACCCTT
TTACTTGCTACTGGTTCAATGGACAAAACAGTGAACATCTGGCAATTTGACCTGGAAACACTTTGCCAAGCAAGGCGCACAGAACATCAG
CTGAAGCAATTTACCGAAGATTGGTCAGAGGAGGATGTCTCAACATGGCTTTGTGCACAAGATTTAAAAGATCTTGTTGGTATTTTCAAG
ATGAATAACATTGATGGAAAAGAACTGTTGAATCTTACAAAAGAAAGTCTGGCTGATGATTTGAAAATTGAATCTCTAGGACTGCGTAGT
AAAGTGCTGAGGAAAATTGAAGAGCTCAGGACCAAGGTTAAATCCCTTTCTTCAGGAATTCCTGATGAATTTATATGTCCAATAACTAGA
GAACTTATGAAAGATCCGGTCATCGCATCAGATGGCTATTCATATGAAAAGGAAGCAATGGAAAATTGGATCAGCAAAAAGAAACGTACA
AGTCCCATGACAAATCTTGTTCTTCCTTCAGCGGTACTTACACCAAATAGGACTCTGAAAATGGCCATCAATAGATGGCTGGAGACACAC
CAAAAGTAAAATTGTTGATATTGTATTATTTATATTTTCAGTGATCTCATTTGAATGATTTATAGGTAAATACTAATCAGACATTATTAA
AAGCAAAACAGGAAAAAGGTAAACTTCTTAAATTTAGTTACCTATAAAAATTGTCAATTTTCATTCTTTAAAAAACACATGGACTTACTA

>9072_9072_3_BAZ2B-WDSUB1_BAZ2B_chr2_160335086_ENST00000392782_WDSUB1_chr2_160116354_ENST00000359774_length(amino acids)=221AA_BP=2
MWSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQD
LKDLVGIFKMNNIDGKELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDPVIASDGYSYEKEAME

--------------------------------------------------------------
>9072_9072_4_BAZ2B-WDSUB1_BAZ2B_chr2_160335086_ENST00000392783_WDSUB1_chr2_160116354_ENST00000359774_length(transcript)=1542nt_BP=641nt
TCCCTTGGCTCCTTTAGGAGCTGATAGGTCATTTATTATTGGAACTGAAATGGTATAAACAATTCTCTCTCTTTTTTTCCCTTGTTAACA
GCAACTTTCATTGTTAGAGAGAGGAGAGAGAGAGAAGCCTTGTTGGTTGACGTCACTTGGTTCATGAAGCCTTCGCCTAGAAGTGAAGCT
GCTGAACAAACCTTGAGAAGAATCATCTCCTGCTTCAATCTGCTGCTGGATAGGAACTAATCAGAGAGAGAGAGGCGGAAGACGGAGAAG
GAGGGAGTCGAAGGCTTTCCCGATCACAAATCTCACCTCCACTACAACTCTCTTTATACTTTTCTTGCAGAAATAATAATAGAAATAAGG
AGGTGGTGGGGTTTCCAAAAATCTTAACCTTCAACCATCTGGGGAAAAGGCAAAAATCCCATCTACCGCAACTCTCAGTTCGAGAGTAAA
GGTTTCCCAACAGTGATGTCACAAGATTGACCACATTGATCACAATATGGAGTCTGGAGAACGGTTACCATCCTCAGCAGCCTCCTCTAC
TACACCAACTTCATCTTCGACACCTTCTGTGGCTTCAGTAGTTTCAAAAGGTGGCCTTTCCACTGGAGTTGCTTCACTTAGCTCTACAAT
CAACCCATGTGGTCAGTGGATAAGTCTGTCATAGTATATGATACTAATACTGAGAATATACTTCACACATTGACTCAGCACACCAGGTAT
GTCACAACTTGTGCTTTTGCACCTAATACCCTTTTACTTGCTACTGGTTCAATGGACAAAACAGTGAACATCTGGCAATTTGACCTGGAA
ACACTTTGCCAAGCAAGGCGCACAGAACATCAGCTGAAGCAATTTACCGAAGATTGGTCAGAGGAGGATGTCTCAACATGGCTTTGTGCA
CAAGATTTAAAAGATCTTGTTGGTATTTTCAAGATGAATAACATTGATGGAAAAGAACTGTTGAATCTTACAAAAGAAAGTCTGGCTGAT
GATTTGAAAATTGAATCTCTAGGACTGCGTAGTAAAGTGCTGAGGAAAATTGAAGAGCTCAGGACCAAGGTTAAATCCCTTTCTTCAGGA
ATTCCTGATGAATTTATATGTCCAATAACTAGAGAACTTATGAAAGATCCGGTCATCGCATCAGATGGCTATTCATATGAAAAGGAAGCA
ATGGAAAATTGGATCAGCAAAAAGAAACGTACAAGTCCCATGACAAATCTTGTTCTTCCTTCAGCGGTACTTACACCAAATAGGACTCTG
AAAATGGCCATCAATAGATGGCTGGAGACACACCAAAAGTAAAATTGTTGATATTGTATTATTTATATTTTCAGTGATCTCATTTGAATG
ATTTATAGGTAAATACTAATCAGACATTATTAAAAGCAAAACAGGAAAAAGGTAAACTTCTTAAATTTAGTTACCTATAAAAATTGTCAA
TTTTCATTCTTTAAAAAACACATGGACTTACTATAAAAGCCTTTTTGTACTAGTGAAAAGAATCTTCAGCTATATAGAAATAAAGTTATA

>9072_9072_4_BAZ2B-WDSUB1_BAZ2B_chr2_160335086_ENST00000392783_WDSUB1_chr2_160116354_ENST00000359774_length(amino acids)=221AA_BP=2
MWSVDKSVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQFDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQD
LKDLVGIFKMNNIDGKELLNLTKESLADDLKIESLGLRSKVLRKIEELRTKVKSLSSGIPDEFICPITRELMKDPVIASDGYSYEKEAME

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BAZ2B-WDSUB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAZ2B-WDSUB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAZ2B-WDSUB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource