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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BBC3-FCGRT (FusionGDB2 ID:9074)

Fusion Gene Summary for BBC3-FCGRT

check button Fusion gene summary
Fusion gene informationFusion gene name: BBC3-FCGRT
Fusion gene ID: 9074
HgeneTgene
Gene symbol

BBC3

FCGRT

Gene ID

27113

2217

Gene nameBCL2 binding component 3Fc fragment of IgG receptor and transporter
SynonymsJFY-1|JFY1|PUMAFCRN|alpha-chain
Cytomap

19q13.32

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionbcl-2-binding component 3p53 up-regulated modulator of apoptosisp53-upregulated modulator of apoptosisIgG receptor FcRn large subunit p51Fc fragment of IgG, receptor, transporter, alphaFcRn alpha chainIgG Fc fragment receptor transporter alpha chainheavy chain of the major histocompatibility complex class I-like Fc receptorimmunoglobulin receptor, in
Modification date2020031320200313
UniProtAcc

Q96PG8

P55899

Ensembl transtripts involved in fusion geneENST00000300880, ENST00000341983, 
ENST00000439096, ENST00000449228, 
ENST00000221466, ENST00000426395, 
ENST00000594823, ENST00000596975, 
ENST00000599988, 
Fusion gene scores* DoF score2 X 3 X 2=1211 X 7 X 6=462
# samples 312
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/462*10)=-1.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BBC3 [Title/Abstract] AND FCGRT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBBC3(47729834)-FCGRT(50017139), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BBC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FCGRT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3695-01ABBC3chr19

47729834

-FCGRTchr19

50017139

+


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Fusion Gene ORF analysis for BBC3-FCGRT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000300880ENST00000221466BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3CDSENST00000300880ENST00000426395BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3CDSENST00000341983ENST00000221466BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3CDSENST00000341983ENST00000426395BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3CDSENST00000439096ENST00000221466BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3CDSENST00000439096ENST00000426395BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3CDSENST00000449228ENST00000221466BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3CDSENST00000449228ENST00000426395BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3UTRENST00000300880ENST00000594823BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3UTRENST00000341983ENST00000594823BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3UTRENST00000439096ENST00000594823BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-3UTRENST00000449228ENST00000594823BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-intronENST00000300880ENST00000596975BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-intronENST00000300880ENST00000599988BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-intronENST00000341983ENST00000596975BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-intronENST00000341983ENST00000599988BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-intronENST00000439096ENST00000596975BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-intronENST00000439096ENST00000599988BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-intronENST00000449228ENST00000596975BBC3chr19

47729834

-FCGRTchr19

50017139

+
intron-intronENST00000449228ENST00000599988BBC3chr19

47729834

-FCGRTchr19

50017139

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for BBC3-FCGRT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BBC3-FCGRT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47729834/:50017139)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BBC3

Q96PG8

FCGRT

P55899

FUNCTION: [Isoform 3]: Does not affect cell growth. {ECO:0000269|PubMed:11463392}.FUNCTION: Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995). {ECO:0000250|UniProtKB:P13599, ECO:0000269|PubMed:10933786, ECO:0000269|PubMed:10998088, ECO:0000269|PubMed:24469444, ECO:0000269|PubMed:28330995, ECO:0000269|PubMed:7964511}.; FUNCTION: (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29. {ECO:0000269|PubMed:30808762, ECO:0000269|PubMed:31104841}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for BBC3-FCGRT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for BBC3-FCGRT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BBC3-FCGRT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BBC3-FCGRT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource