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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THSD7A-PRKAR1B (FusionGDB2 ID:90785)

Fusion Gene Summary for THSD7A-PRKAR1B

check button Fusion gene summary
Fusion gene informationFusion gene name: THSD7A-PRKAR1B
Fusion gene ID: 90785
HgeneTgene
Gene symbol

THSD7A

PRKAR1B

Gene ID

221981

5575

Gene namethrombospondin type 1 domain containing 7Aprotein kinase cAMP-dependent type I regulatory subunit beta
Synonyms-PRKAR1
Cytomap

7p21.3

7p22.3

Type of geneprotein-codingprotein-coding
Descriptionthrombospondin type-1 domain-containing protein 7Athrombospondin, type I, domain containing 7AcAMP-dependent protein kinase type I-beta regulatory subunitprotein kinase, cAMP-dependent, regulatory subunit type I betaprotein kinase, cAMP-dependent, regulatory, type I, beta
Modification date2020032220200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000423059, ENST00000480061, 
ENST00000488474, ENST00000360274, 
ENST00000403562, ENST00000406797, 
ENST00000537384, ENST00000544935, 
Fusion gene scores* DoF score2 X 2 X 2=814 X 10 X 8=1120
# samples 215
** MAII scorelog2(2/8*10)=1.32192809488736log2(15/1120*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THSD7A [Title/Abstract] AND PRKAR1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHSD7A(11457077)-PRKAR1B(591107), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKAR1B

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984


check buttonFusion gene breakpoints across THSD7A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKAR1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7470-01ATHSD7Achr7

11457077

-PRKAR1Bchr7

591107

-


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Fusion Gene ORF analysis for THSD7A-PRKAR1B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000423059ENST00000488474THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
In-frameENST00000423059ENST00000360274THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
In-frameENST00000423059ENST00000403562THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
In-frameENST00000423059ENST00000406797THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
In-frameENST00000423059ENST00000537384THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
In-frameENST00000423059ENST00000544935THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
intron-3CDSENST00000480061ENST00000360274THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
intron-3CDSENST00000480061ENST00000403562THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
intron-3CDSENST00000480061ENST00000406797THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
intron-3CDSENST00000480061ENST00000537384THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
intron-3CDSENST00000480061ENST00000544935THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-
intron-intronENST00000480061ENST00000488474THSD7Achr7

11457077

-PRKAR1Bchr7

591107

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000423059THSD7Achr711457077-ENST00000544935PRKAR1Bchr7591107-5277378916240431293
ENST00000423059THSD7Achr711457077-ENST00000537384PRKAR1Bchr7591107-5277378916240431293
ENST00000423059THSD7Achr711457077-ENST00000406797PRKAR1Bchr7591107-5276378916240431293
ENST00000423059THSD7Achr711457077-ENST00000403562PRKAR1Bchr7591107-4732378916240431293
ENST00000423059THSD7Achr711457077-ENST00000360274PRKAR1Bchr7591107-4724378916240431293

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423059ENST00000544935THSD7Achr711457077-PRKAR1Bchr7591107-0.0011184890.9988815
ENST00000423059ENST00000537384THSD7Achr711457077-PRKAR1Bchr7591107-0.0011184890.9988815
ENST00000423059ENST00000406797THSD7Achr711457077-PRKAR1Bchr7591107-0.0011284690.9988715
ENST00000423059ENST00000403562THSD7Achr711457077-PRKAR1Bchr7591107-0.0012001560.9987998
ENST00000423059ENST00000360274THSD7Achr711457077-PRKAR1Bchr7591107-0.0011839710.998816

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Fusion Genomic Features for THSD7A-PRKAR1B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THSD7A-PRKAR1B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:11457077/chr7:591107)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728267_31511791658.0Coiled coilOntology_term=ECO:0000255
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-17281035_109511791658.0DomainTSP type-1 13
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-17281096_116311791658.0DomainTSP type-1 14
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728120_19211791658.0DomainTSP type-1 2
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728194_24711791658.0DomainTSP type-1 3
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728360_41611791658.0DomainTSP type-1 4
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728423_51011791658.0DomainTSP type-1 5
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728512_57411791658.0DomainTSP type-1 6
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-172857_11611791658.0DomainTSP type-1 1
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728634_69511791658.0DomainTSP type-1 7
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728696_76911791658.0DomainTSP type-1 8
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728771_83111791658.0DomainTSP type-1 9
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728832_90411791658.0DomainTSP type-1 10
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728906_95911791658.0DomainTSP type-1 11
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-1728960_103311791658.0DomainTSP type-1 12

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-17281166_122011791658.0DomainTSP type-1 15
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-17281221_128411791658.0DomainTSP type-1 16
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-17281286_134111791658.0DomainTSP type-1 17
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-17281342_141211791658.0DomainTSP type-1 18
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-17281414_147511791658.0DomainTSP type-1 19
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-17281629_165711791658.0Topological domainCytoplasmic
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-172848_160711791658.0Topological domainExtracellular
HgeneTHSD7Achr7:11457077chr7:591107ENST00000423059-17281608_162811791658.0TransmembraneHelical
TgenePRKAR1Bchr7:11457077chr7:591107ENST0000036027481196_100297382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:11457077chr7:591107ENST0000040356281196_100297382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:11457077chr7:591107ENST0000040679781196_100297382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:11457077chr7:591107ENST0000053738481196_100297382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:11457077chr7:591107ENST0000054493581196_100297382.0MotifNote=Pseudophosphorylation motif
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000360274811137_254297382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000360274811255_381297382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000403562811137_254297382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000403562811255_381297382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000406797811137_254297382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000406797811255_381297382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000537384811137_254297382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000537384811255_381297382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000544935811137_254297382.0Nucleotide bindingNote=cAMP 1
TgenePRKAR1Bchr7:11457077chr7:591107ENST00000544935811255_381297382.0Nucleotide bindingNote=cAMP 2
TgenePRKAR1Bchr7:11457077chr7:591107ENST000003602748112_136297382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:11457077chr7:591107ENST000004035628112_136297382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:11457077chr7:591107ENST000004067978112_136297382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:11457077chr7:591107ENST000005373848112_136297382.0RegionNote=Dimerization and phosphorylation
TgenePRKAR1Bchr7:11457077chr7:591107ENST000005449358112_136297382.0RegionNote=Dimerization and phosphorylation


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Fusion Gene Sequence for THSD7A-PRKAR1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90785_90785_1_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000360274_length(transcript)=4724nt_BP=3789nt
ATTCTGCGAGGAATGGCAGCGGCAGCAGCATCCCCGCCAGAGGCGGCGGCGGCGGCGGCAGCGGCCACGGCCACCACCGCGGACGCTATT
GTTCCCTGGTGTTAGACGCGCTCTCCCTCCTTCTCATCTGAAGCGAACAATAGCAGGAAAGAGCTTTGCTTTCTGTACTCTTTGAAAAGA
CGTTCCAAGAGCGGAGAAAAATTCCCTGCCGAGCGTGCTACGGCTCTGGACCCTGGAGTGGCTGCAGGCGGCATGGGGCTGCAAGCCAGG
CGCTGGGCGTCCGGGAGCCGGGGCGCTGCGGGGCCGCGCCGGGGCGTCCTGCAGCTGCTGCCGCTGCCGCTGCCGCTGCCGCTGCTCCTG
CTGCTGCTGCTACGCCCGGGCGCCGGCAGGGCTGCGGCGCAGGGCGAGGCGGAGGCGCCCACCCTCTATCTGTGGAAGACTGGTCCATGG
GGCCGATGTATGGGAGATGAATGTGGTCCCGGAGGCATCCAAACGAGGGCTGTGTGGTGTGCTCATGTGGAGGGATGGACTACACTGCAT
ACTAACTGTAAGCAGGCCGAGAGACCCAATAACCAGCAGAATTGTTTCAAAGTTTGCGATTGGCACAAAGAGTTGTACGACTGGAGACTG
GGACCTTGGAATCAGTGTCAGCCCGTGATTTCAAAAAGCCTAGAGAAACCTCTTGAGTGCATTAAGGGGGAAGAAGGTATTCAGGTGAGG
GAGATAGCGTGCATCCAGAAAGACAAAGACATTCCTGCGGAGGATATCATCTGTGAGTACTTTGAGCCCAAGCCTCTCCTGGAGCAGGCT
TGCCTCATTCCTTGCCAGCAAGATTGCATCGTGTCTGAATTTTCTGCCTGGTCCGAATGCTCCAAGACCTGCGGCAGCGGGCTCCAGCAC
CGGACGCGTCATGTGGTGGCGCCCCCGCAGTTCGGAGGCTCTGGCTGTCCAAACCTGACGGAGTTCCAGGTGTGCCAATCCAGTCCATGC
GAGGCCGAGGAGCTCAGGTACAGCCTGCATGTGGGGCCCTGGAGCACCTGCTCAATGCCCCACTCCCGACAAGTAAGACAAGCAAGGAGA
CGCGGGAAGAATAAAGAACGGGAAAAGGACCGCAGCAAAGGAGTAAAGGATCCAGAAGCCCGCGAGCTTATTAAGAAAAAGAGAAACAGA
AACAGGCAGAACAGACAAGAGAACAAATATTGGGACATCCAGATTGGATATCAGACCAGAGAGGTTATGTGCATTAACAAGACGGGGAAA
GCTGCTGATTTAAGCTTTTGCCAGCAAGAGAAGCTTCCAATGACCTTCCAGTCCTGTGTGATCACCAAAGAGTGCCAGGTTTCCGAGTGG
TCAGAGTGGAGCCCCTGCTCAAAAACATGCCATGACATGGTGTCCCCTGCAGGCACTCGTGTAAGGACACGAACCATCAGGCAGTTTCCC
ATTGGCAGTGAAAAGGAGTGTCCAGAATTTGAAGAAAAAGAACCCTGTTTGTCTCAAGGAGATGGAGTTGTCCCCTGTGCCACGTATGGC
TGGAGAACTACAGAGTGGACTGAGTGCCGTGTGGACCCTTTGCTCAGTCAGCAGGACAAGAGGCGCGGCAACCAGACGGCCCTCTGTGGA
GGGGGCATCCAGACCCGAGAGGTGTACTGCGTGCAGGCCAACGAAAACCTCCTCTCACAATTAAGTACCCACAAGAACAAAGAAGCCTCA
AAGCCAATGGACTTAAAATTATGCACTGGACCTATCCCTAATACTACACAGCTGTGCCACATTCCTTGTCCAACTGAATGTGAAGTTTCA
CCTTGGTCAGCTTGGGGACCTTGTACTTATGAAAACTGTAATGATCAGCAAGGGAAAAAAGGCTTCAAACTGAGGAAGCGGCGCATTACC
AATGAGCCCACTGGAGGCTCTGGGGTAACCGGAAACTGCCCTCACTTACTGGAAGCCATTCCCTGTGAAGAGCCTGCCTGTTATGACTGG
AAAGCAGTGAGACTGGGAAACTGCGAGCCAGATAACGGAAAGGAGTGTGGTCCAGGCACGCAAGTTCAAGAGGTTGTGTGCATCAACAGT
GATGGAGAAGAAGTTGACAGACAGCTGTGCAGAGATGCCATCTTCCCCATCCCTGTGGCCTGTGATGCCCCATGCCCGAAAGACTGTGTG
CTCAGCACATGGTCTACGTGGTCCTCCTGCTCACACACCTGCTCAGGGAAAACGACAGAAGGGAAACAGATACGAGCACGATCCATTCTG
GCCTATGCGGGTGAAGAAGGTGGAATTCGCTGTCCAAATAGCAGTGCTTTGCAAGAAGTACGAAGCTGTAATGAGCATCCTTGCACAGTG
TACCACTGGCAAACTGGTCCCTGGGGCCAGTGCATTGAGGACACCTCAGTATCGTCCTTCAACACAACTACGACTTGGAATGGGGAGGCC
TCCTGCTCTGTCGGCATGCAGACAAGAAAAGTCATCTGTGTGCGAGTCAATGTGGGCCAAGTGGGACCCAAAAAATGTCCTGAAAGCCTT
CGACCTGAAACTGTAAGGCCTTGTCTGCTTCCTTGTAAGAAGGACTGTATTGTGACCCCATATAGTGACTGGACATCATGCCCCTCTTCG
TGTAAAGAAGGGGACTCCAGTATCAGGAAGCAGTCTAGGCATCGGGTCATCATTCAGCTGCCAGCCAACGGGGGCCGAGACTGCACAGAT
CCCCTCTATGAAGAGAAGGCCTGTGAGGCACCTCAAGCGTGCCAAAGCTACAGGTGGAAGACTCACAAATGGCGCAGATGCCAATTAGTC
CCTTGGAGCGTGCAACAAGACAGCCCTGGAGCACAGGAAGGCTGTGGGCCTGGGCGACAGGCAAGAGCCATTACTTGTCGCAAGCAAGAT
GGAGGACAGGCTGGAATCCATGAGTGCCTACAGTATGCAGGCCCTGTGCCAGCCCTTACCCAGGCCTGCCAGATCCCCTGCCAGGATGAC
TGTCAATTGACCAGCTGGTCCAAGTTTTCTTCATGCAATGGAGACTGTGGTGCAGTTAGGACCAGAAAGCGCACTCTTGTTGGAAAAAGT
AAAAAGAAGGAAAAATGTAAAAATTCCCATTTGTATCCCCTGATTGAGACTCAGTATTGTCCTTGTGACAAATATAATGCACAACCTGTG
GGGAACTGGTCAGACTGTATTTTACCAGAGGGAAAAGTGGAAGTGTTGCTGGGAATGAAAGTACAAGGAGACATCAAGGAATGCGGACAA
GGATATCGTTACCAAGCAATGGCATGCTACGATCAAAATGGCAGGCTTGTGGAAACATCTAGATGTAACAGCCATGGTTACATTGAGGAG
GCCTGCATCATCCCCTGCCCCTCAGACTGCAAGCTCAGTGAGTGGTCCAACTGGTCGCGCTGCAGCAAGTCCTGTGGGAGTGGTGTGAAG
GTTCGTTCTAAATGGCTGCGTGAAAAACCATATAATGGAGGAAGGCCTTGCCCCAAACTGGACCATGTCAACCAGGCACAGGTGTATGAG
GTTGTCCCATGCCACAGTGACTGCAACCAGTACCTATGGGTCACAGAGCCCTGGAGCATCTGCAAGGTGACCTTTGTGAATATGCGGGAG
AACTGTGGAGAGGGCGTGCAAACCCGAAAAGTGAGATGCATGCAGAATACAGCAGATGGCCCTTCTGAACATGTAGAGGATTACCTCTGT
GACCCAGAAGAGATGCCCCTGGGCTCTAGAGTGTGCAAATTACCATGCCCTGAGGACTGTGTGATATCTGAATGGGGTCCATGGACCCAA
TGTGTTTTGGGCACCGCGTCCGTGCTGCAGCGCCGGTCCCCCAATGAGGAGTACGTGGAGGTGGGGCGCCTGGGACCCTCTGACTACTTC
GGGGAGATTGCACTGCTGCTGAACCGGCCCCGGGCGGCCACTGTCGTGGCCCGGGGGCCCCTCAAGTGTGTGAAGCTGGACCGGCCCCGC
TTCGAGCGTGTGCTGGGGCCCTGCTCTGAGATCCTCAAGAGGAACATTCAGCGTTACAACAGCTTCATCTCCCTCACCGTCTGAGCACAG
CTCCCGCCCTGCAGCCCCAGCTCCCCAGTGTGGTGGCCGTGCCCTGCTCGTCTGTGTCGGGGGCCCGGGAGCCGCTGTGTGAGGTGTGGG
CCGGGTGGGGCTGGGTCCCGGCAGCGTGAGGACTGCCCCTTCCCCGGACTCACTTTTTGGAATAAATGATCACCTTGTGCATTTCCAAAT
CAAAGGACAAGCGGACAAAATGCATCCCAAGATCAAGGAAGGGACAGGCCAGCTTCCTCCCCACACGCCTCCCCGGCTGCCTCTGTGGGC
TTCTCCTGGGGGGCCCACCCCACCCCTGCCAGTCTCCTGGAGATGCTTGAGGATCGGTCCTCCCCAGAACCAGGCCAGGACGTTGCCCCT
GGGGCCTGGTGACCCTGTGAGGTCAGGTCCCCCAGATTGAGGTCTGAGTGTGGGCAAGTGTGTCAAAAGGGGCTGCCCCCCAGGGGAGAT
GAGGCTGAGAGCAGGGAGTTGAGGCCGAAGAAGTCAAGGCCCCTCCCGCAAATGTGTACCCCTGCCCGCGCCACTGCACCCCGCCGCACC
CCCACCTCCCCCGGGGGCCCTGCTGCGGATGCCGGAGTGGGAGAGTCTCTGAGCTGTGAGATTGATCTTGCCCCTAATTGGAGAGGAAGC

>90785_90785_1_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000360274_length(amino acids)=1293AA_BP=1204
MYSLKRRSKSGEKFPAERATALDPGVAAGGMGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYL
WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGE
EGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV
CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMC
INKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV
PCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCP
TECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQE
VVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCN
EHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDW
TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAI
TCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDK
YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKS
CGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH
VEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCV

--------------------------------------------------------------
>90785_90785_2_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000403562_length(transcript)=4732nt_BP=3789nt
ATTCTGCGAGGAATGGCAGCGGCAGCAGCATCCCCGCCAGAGGCGGCGGCGGCGGCGGCAGCGGCCACGGCCACCACCGCGGACGCTATT
GTTCCCTGGTGTTAGACGCGCTCTCCCTCCTTCTCATCTGAAGCGAACAATAGCAGGAAAGAGCTTTGCTTTCTGTACTCTTTGAAAAGA
CGTTCCAAGAGCGGAGAAAAATTCCCTGCCGAGCGTGCTACGGCTCTGGACCCTGGAGTGGCTGCAGGCGGCATGGGGCTGCAAGCCAGG
CGCTGGGCGTCCGGGAGCCGGGGCGCTGCGGGGCCGCGCCGGGGCGTCCTGCAGCTGCTGCCGCTGCCGCTGCCGCTGCCGCTGCTCCTG
CTGCTGCTGCTACGCCCGGGCGCCGGCAGGGCTGCGGCGCAGGGCGAGGCGGAGGCGCCCACCCTCTATCTGTGGAAGACTGGTCCATGG
GGCCGATGTATGGGAGATGAATGTGGTCCCGGAGGCATCCAAACGAGGGCTGTGTGGTGTGCTCATGTGGAGGGATGGACTACACTGCAT
ACTAACTGTAAGCAGGCCGAGAGACCCAATAACCAGCAGAATTGTTTCAAAGTTTGCGATTGGCACAAAGAGTTGTACGACTGGAGACTG
GGACCTTGGAATCAGTGTCAGCCCGTGATTTCAAAAAGCCTAGAGAAACCTCTTGAGTGCATTAAGGGGGAAGAAGGTATTCAGGTGAGG
GAGATAGCGTGCATCCAGAAAGACAAAGACATTCCTGCGGAGGATATCATCTGTGAGTACTTTGAGCCCAAGCCTCTCCTGGAGCAGGCT
TGCCTCATTCCTTGCCAGCAAGATTGCATCGTGTCTGAATTTTCTGCCTGGTCCGAATGCTCCAAGACCTGCGGCAGCGGGCTCCAGCAC
CGGACGCGTCATGTGGTGGCGCCCCCGCAGTTCGGAGGCTCTGGCTGTCCAAACCTGACGGAGTTCCAGGTGTGCCAATCCAGTCCATGC
GAGGCCGAGGAGCTCAGGTACAGCCTGCATGTGGGGCCCTGGAGCACCTGCTCAATGCCCCACTCCCGACAAGTAAGACAAGCAAGGAGA
CGCGGGAAGAATAAAGAACGGGAAAAGGACCGCAGCAAAGGAGTAAAGGATCCAGAAGCCCGCGAGCTTATTAAGAAAAAGAGAAACAGA
AACAGGCAGAACAGACAAGAGAACAAATATTGGGACATCCAGATTGGATATCAGACCAGAGAGGTTATGTGCATTAACAAGACGGGGAAA
GCTGCTGATTTAAGCTTTTGCCAGCAAGAGAAGCTTCCAATGACCTTCCAGTCCTGTGTGATCACCAAAGAGTGCCAGGTTTCCGAGTGG
TCAGAGTGGAGCCCCTGCTCAAAAACATGCCATGACATGGTGTCCCCTGCAGGCACTCGTGTAAGGACACGAACCATCAGGCAGTTTCCC
ATTGGCAGTGAAAAGGAGTGTCCAGAATTTGAAGAAAAAGAACCCTGTTTGTCTCAAGGAGATGGAGTTGTCCCCTGTGCCACGTATGGC
TGGAGAACTACAGAGTGGACTGAGTGCCGTGTGGACCCTTTGCTCAGTCAGCAGGACAAGAGGCGCGGCAACCAGACGGCCCTCTGTGGA
GGGGGCATCCAGACCCGAGAGGTGTACTGCGTGCAGGCCAACGAAAACCTCCTCTCACAATTAAGTACCCACAAGAACAAAGAAGCCTCA
AAGCCAATGGACTTAAAATTATGCACTGGACCTATCCCTAATACTACACAGCTGTGCCACATTCCTTGTCCAACTGAATGTGAAGTTTCA
CCTTGGTCAGCTTGGGGACCTTGTACTTATGAAAACTGTAATGATCAGCAAGGGAAAAAAGGCTTCAAACTGAGGAAGCGGCGCATTACC
AATGAGCCCACTGGAGGCTCTGGGGTAACCGGAAACTGCCCTCACTTACTGGAAGCCATTCCCTGTGAAGAGCCTGCCTGTTATGACTGG
AAAGCAGTGAGACTGGGAAACTGCGAGCCAGATAACGGAAAGGAGTGTGGTCCAGGCACGCAAGTTCAAGAGGTTGTGTGCATCAACAGT
GATGGAGAAGAAGTTGACAGACAGCTGTGCAGAGATGCCATCTTCCCCATCCCTGTGGCCTGTGATGCCCCATGCCCGAAAGACTGTGTG
CTCAGCACATGGTCTACGTGGTCCTCCTGCTCACACACCTGCTCAGGGAAAACGACAGAAGGGAAACAGATACGAGCACGATCCATTCTG
GCCTATGCGGGTGAAGAAGGTGGAATTCGCTGTCCAAATAGCAGTGCTTTGCAAGAAGTACGAAGCTGTAATGAGCATCCTTGCACAGTG
TACCACTGGCAAACTGGTCCCTGGGGCCAGTGCATTGAGGACACCTCAGTATCGTCCTTCAACACAACTACGACTTGGAATGGGGAGGCC
TCCTGCTCTGTCGGCATGCAGACAAGAAAAGTCATCTGTGTGCGAGTCAATGTGGGCCAAGTGGGACCCAAAAAATGTCCTGAAAGCCTT
CGACCTGAAACTGTAAGGCCTTGTCTGCTTCCTTGTAAGAAGGACTGTATTGTGACCCCATATAGTGACTGGACATCATGCCCCTCTTCG
TGTAAAGAAGGGGACTCCAGTATCAGGAAGCAGTCTAGGCATCGGGTCATCATTCAGCTGCCAGCCAACGGGGGCCGAGACTGCACAGAT
CCCCTCTATGAAGAGAAGGCCTGTGAGGCACCTCAAGCGTGCCAAAGCTACAGGTGGAAGACTCACAAATGGCGCAGATGCCAATTAGTC
CCTTGGAGCGTGCAACAAGACAGCCCTGGAGCACAGGAAGGCTGTGGGCCTGGGCGACAGGCAAGAGCCATTACTTGTCGCAAGCAAGAT
GGAGGACAGGCTGGAATCCATGAGTGCCTACAGTATGCAGGCCCTGTGCCAGCCCTTACCCAGGCCTGCCAGATCCCCTGCCAGGATGAC
TGTCAATTGACCAGCTGGTCCAAGTTTTCTTCATGCAATGGAGACTGTGGTGCAGTTAGGACCAGAAAGCGCACTCTTGTTGGAAAAAGT
AAAAAGAAGGAAAAATGTAAAAATTCCCATTTGTATCCCCTGATTGAGACTCAGTATTGTCCTTGTGACAAATATAATGCACAACCTGTG
GGGAACTGGTCAGACTGTATTTTACCAGAGGGAAAAGTGGAAGTGTTGCTGGGAATGAAAGTACAAGGAGACATCAAGGAATGCGGACAA
GGATATCGTTACCAAGCAATGGCATGCTACGATCAAAATGGCAGGCTTGTGGAAACATCTAGATGTAACAGCCATGGTTACATTGAGGAG
GCCTGCATCATCCCCTGCCCCTCAGACTGCAAGCTCAGTGAGTGGTCCAACTGGTCGCGCTGCAGCAAGTCCTGTGGGAGTGGTGTGAAG
GTTCGTTCTAAATGGCTGCGTGAAAAACCATATAATGGAGGAAGGCCTTGCCCCAAACTGGACCATGTCAACCAGGCACAGGTGTATGAG
GTTGTCCCATGCCACAGTGACTGCAACCAGTACCTATGGGTCACAGAGCCCTGGAGCATCTGCAAGGTGACCTTTGTGAATATGCGGGAG
AACTGTGGAGAGGGCGTGCAAACCCGAAAAGTGAGATGCATGCAGAATACAGCAGATGGCCCTTCTGAACATGTAGAGGATTACCTCTGT
GACCCAGAAGAGATGCCCCTGGGCTCTAGAGTGTGCAAATTACCATGCCCTGAGGACTGTGTGATATCTGAATGGGGTCCATGGACCCAA
TGTGTTTTGGGCACCGCGTCCGTGCTGCAGCGCCGGTCCCCCAATGAGGAGTACGTGGAGGTGGGGCGCCTGGGACCCTCTGACTACTTC
GGGGAGATTGCACTGCTGCTGAACCGGCCCCGGGCGGCCACTGTCGTGGCCCGGGGGCCCCTCAAGTGTGTGAAGCTGGACCGGCCCCGC
TTCGAGCGTGTGCTGGGGCCCTGCTCTGAGATCCTCAAGAGGAACATTCAGCGTTACAACAGCTTCATCTCCCTCACCGTCTGAGCACAG
CTCCCGCCCTGCAGCCCCAGCTCCCCAGTGTGGTGGCCGTGCCCTGCTCGTCTGTGTCGGGGGCCCGGGAGCCGCTGTGTGAGGTGTGGG
CCGGGTGGGGCTGGGTCCCGGCAGCGTGAGGACTGCCCCTTCCCCGGACTCACTTTTTGGAATAAATGATCACCTTGTGCATTTCCAAAT
CAAAGGACAAGCGGACAAAATGCATCCCAAGATCAAGGAAGGGACAGGCCAGCTTCCTCCCCACACGCCTCCCCGGCTGCCTCTGTGGGC
TTCTCCTGGGGGGCCCACCCCACCCCTGCCAGTCTCCTGGAGATGCTTGAGGATCGGTCCTCCCCAGAACCAGGCCAGGACGTTGCCCCT
GGGGCCTGGTGACCCTGTGAGGTCAGGTCCCCCAGATTGAGGTCTGAGTGTGGGCAAGTGTGTCAAAAGGGGCTGCCCCCCAGGGGAGAT
GAGGCTGAGAGCAGGGAGTTGAGGCCGAAGAAGTCAAGGCCCCTCCCGCAAATGTGTACCCCTGCCCGCGCCACTGCACCCCGCCGCACC
CCCACCTCCCCCGGGGGCCCTGCTGCGGATGCCGGAGTGGGAGAGTCTCTGAGCTGTGAGATTGATCTTGCCCCTAATTGGAGAGGAAGC

>90785_90785_2_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000403562_length(amino acids)=1293AA_BP=1204
MYSLKRRSKSGEKFPAERATALDPGVAAGGMGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYL
WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGE
EGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV
CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMC
INKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV
PCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCP
TECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQE
VVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCN
EHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDW
TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAI
TCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDK
YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKS
CGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH
VEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCV

--------------------------------------------------------------
>90785_90785_3_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000406797_length(transcript)=5276nt_BP=3789nt
ATTCTGCGAGGAATGGCAGCGGCAGCAGCATCCCCGCCAGAGGCGGCGGCGGCGGCGGCAGCGGCCACGGCCACCACCGCGGACGCTATT
GTTCCCTGGTGTTAGACGCGCTCTCCCTCCTTCTCATCTGAAGCGAACAATAGCAGGAAAGAGCTTTGCTTTCTGTACTCTTTGAAAAGA
CGTTCCAAGAGCGGAGAAAAATTCCCTGCCGAGCGTGCTACGGCTCTGGACCCTGGAGTGGCTGCAGGCGGCATGGGGCTGCAAGCCAGG
CGCTGGGCGTCCGGGAGCCGGGGCGCTGCGGGGCCGCGCCGGGGCGTCCTGCAGCTGCTGCCGCTGCCGCTGCCGCTGCCGCTGCTCCTG
CTGCTGCTGCTACGCCCGGGCGCCGGCAGGGCTGCGGCGCAGGGCGAGGCGGAGGCGCCCACCCTCTATCTGTGGAAGACTGGTCCATGG
GGCCGATGTATGGGAGATGAATGTGGTCCCGGAGGCATCCAAACGAGGGCTGTGTGGTGTGCTCATGTGGAGGGATGGACTACACTGCAT
ACTAACTGTAAGCAGGCCGAGAGACCCAATAACCAGCAGAATTGTTTCAAAGTTTGCGATTGGCACAAAGAGTTGTACGACTGGAGACTG
GGACCTTGGAATCAGTGTCAGCCCGTGATTTCAAAAAGCCTAGAGAAACCTCTTGAGTGCATTAAGGGGGAAGAAGGTATTCAGGTGAGG
GAGATAGCGTGCATCCAGAAAGACAAAGACATTCCTGCGGAGGATATCATCTGTGAGTACTTTGAGCCCAAGCCTCTCCTGGAGCAGGCT
TGCCTCATTCCTTGCCAGCAAGATTGCATCGTGTCTGAATTTTCTGCCTGGTCCGAATGCTCCAAGACCTGCGGCAGCGGGCTCCAGCAC
CGGACGCGTCATGTGGTGGCGCCCCCGCAGTTCGGAGGCTCTGGCTGTCCAAACCTGACGGAGTTCCAGGTGTGCCAATCCAGTCCATGC
GAGGCCGAGGAGCTCAGGTACAGCCTGCATGTGGGGCCCTGGAGCACCTGCTCAATGCCCCACTCCCGACAAGTAAGACAAGCAAGGAGA
CGCGGGAAGAATAAAGAACGGGAAAAGGACCGCAGCAAAGGAGTAAAGGATCCAGAAGCCCGCGAGCTTATTAAGAAAAAGAGAAACAGA
AACAGGCAGAACAGACAAGAGAACAAATATTGGGACATCCAGATTGGATATCAGACCAGAGAGGTTATGTGCATTAACAAGACGGGGAAA
GCTGCTGATTTAAGCTTTTGCCAGCAAGAGAAGCTTCCAATGACCTTCCAGTCCTGTGTGATCACCAAAGAGTGCCAGGTTTCCGAGTGG
TCAGAGTGGAGCCCCTGCTCAAAAACATGCCATGACATGGTGTCCCCTGCAGGCACTCGTGTAAGGACACGAACCATCAGGCAGTTTCCC
ATTGGCAGTGAAAAGGAGTGTCCAGAATTTGAAGAAAAAGAACCCTGTTTGTCTCAAGGAGATGGAGTTGTCCCCTGTGCCACGTATGGC
TGGAGAACTACAGAGTGGACTGAGTGCCGTGTGGACCCTTTGCTCAGTCAGCAGGACAAGAGGCGCGGCAACCAGACGGCCCTCTGTGGA
GGGGGCATCCAGACCCGAGAGGTGTACTGCGTGCAGGCCAACGAAAACCTCCTCTCACAATTAAGTACCCACAAGAACAAAGAAGCCTCA
AAGCCAATGGACTTAAAATTATGCACTGGACCTATCCCTAATACTACACAGCTGTGCCACATTCCTTGTCCAACTGAATGTGAAGTTTCA
CCTTGGTCAGCTTGGGGACCTTGTACTTATGAAAACTGTAATGATCAGCAAGGGAAAAAAGGCTTCAAACTGAGGAAGCGGCGCATTACC
AATGAGCCCACTGGAGGCTCTGGGGTAACCGGAAACTGCCCTCACTTACTGGAAGCCATTCCCTGTGAAGAGCCTGCCTGTTATGACTGG
AAAGCAGTGAGACTGGGAAACTGCGAGCCAGATAACGGAAAGGAGTGTGGTCCAGGCACGCAAGTTCAAGAGGTTGTGTGCATCAACAGT
GATGGAGAAGAAGTTGACAGACAGCTGTGCAGAGATGCCATCTTCCCCATCCCTGTGGCCTGTGATGCCCCATGCCCGAAAGACTGTGTG
CTCAGCACATGGTCTACGTGGTCCTCCTGCTCACACACCTGCTCAGGGAAAACGACAGAAGGGAAACAGATACGAGCACGATCCATTCTG
GCCTATGCGGGTGAAGAAGGTGGAATTCGCTGTCCAAATAGCAGTGCTTTGCAAGAAGTACGAAGCTGTAATGAGCATCCTTGCACAGTG
TACCACTGGCAAACTGGTCCCTGGGGCCAGTGCATTGAGGACACCTCAGTATCGTCCTTCAACACAACTACGACTTGGAATGGGGAGGCC
TCCTGCTCTGTCGGCATGCAGACAAGAAAAGTCATCTGTGTGCGAGTCAATGTGGGCCAAGTGGGACCCAAAAAATGTCCTGAAAGCCTT
CGACCTGAAACTGTAAGGCCTTGTCTGCTTCCTTGTAAGAAGGACTGTATTGTGACCCCATATAGTGACTGGACATCATGCCCCTCTTCG
TGTAAAGAAGGGGACTCCAGTATCAGGAAGCAGTCTAGGCATCGGGTCATCATTCAGCTGCCAGCCAACGGGGGCCGAGACTGCACAGAT
CCCCTCTATGAAGAGAAGGCCTGTGAGGCACCTCAAGCGTGCCAAAGCTACAGGTGGAAGACTCACAAATGGCGCAGATGCCAATTAGTC
CCTTGGAGCGTGCAACAAGACAGCCCTGGAGCACAGGAAGGCTGTGGGCCTGGGCGACAGGCAAGAGCCATTACTTGTCGCAAGCAAGAT
GGAGGACAGGCTGGAATCCATGAGTGCCTACAGTATGCAGGCCCTGTGCCAGCCCTTACCCAGGCCTGCCAGATCCCCTGCCAGGATGAC
TGTCAATTGACCAGCTGGTCCAAGTTTTCTTCATGCAATGGAGACTGTGGTGCAGTTAGGACCAGAAAGCGCACTCTTGTTGGAAAAAGT
AAAAAGAAGGAAAAATGTAAAAATTCCCATTTGTATCCCCTGATTGAGACTCAGTATTGTCCTTGTGACAAATATAATGCACAACCTGTG
GGGAACTGGTCAGACTGTATTTTACCAGAGGGAAAAGTGGAAGTGTTGCTGGGAATGAAAGTACAAGGAGACATCAAGGAATGCGGACAA
GGATATCGTTACCAAGCAATGGCATGCTACGATCAAAATGGCAGGCTTGTGGAAACATCTAGATGTAACAGCCATGGTTACATTGAGGAG
GCCTGCATCATCCCCTGCCCCTCAGACTGCAAGCTCAGTGAGTGGTCCAACTGGTCGCGCTGCAGCAAGTCCTGTGGGAGTGGTGTGAAG
GTTCGTTCTAAATGGCTGCGTGAAAAACCATATAATGGAGGAAGGCCTTGCCCCAAACTGGACCATGTCAACCAGGCACAGGTGTATGAG
GTTGTCCCATGCCACAGTGACTGCAACCAGTACCTATGGGTCACAGAGCCCTGGAGCATCTGCAAGGTGACCTTTGTGAATATGCGGGAG
AACTGTGGAGAGGGCGTGCAAACCCGAAAAGTGAGATGCATGCAGAATACAGCAGATGGCCCTTCTGAACATGTAGAGGATTACCTCTGT
GACCCAGAAGAGATGCCCCTGGGCTCTAGAGTGTGCAAATTACCATGCCCTGAGGACTGTGTGATATCTGAATGGGGTCCATGGACCCAA
TGTGTTTTGGGCACCGCGTCCGTGCTGCAGCGCCGGTCCCCCAATGAGGAGTACGTGGAGGTGGGGCGCCTGGGACCCTCTGACTACTTC
GGGGAGATTGCACTGCTGCTGAACCGGCCCCGGGCGGCCACTGTCGTGGCCCGGGGGCCCCTCAAGTGTGTGAAGCTGGACCGGCCCCGC
TTCGAGCGTGTGCTGGGGCCCTGCTCTGAGATCCTCAAGAGGAACATTCAGCGTTACAACAGCTTCATCTCCCTCACCGTCTGAGCACAG
CTCCCGCCCTGCAGCCCCAGCTCCCCAGTGTGGTGGCCGTGCCCTGCTCGTCTGTGTCGGGGGCCCGGGAGCCGCTGTGTGAGGTGTGGG
CCGGGTGGGGCTGGGTCCCGGCAGCGTGAGGACTGCCCCTTCCCCGGACTCACTTTTTGGAATAAATGATCACCTTGTGCATTTCCAAAT
CAAAGGACAAGCGGACAAAATGCATCCCAAGATCAAGGAAGGGACAGGCCAGCTTCCTCCCCACACGCCTCCCCGGCTGCCTCTGTGGGC
TTCTCCTGGGGGGCCCACCCCACCCCTGCCAGTCTCCTGGAGATGCTTGAGGATCGGTCCTCCCCAGAACCAGGCCAGGACGTTGCCCCT
GGGGCCTGGTGACCCTGTGAGGTCAGGTCCCCCAGATTGAGGTCTGAGTGTGGGCAAGTGTGTCAAAAGGGGCTGCCCCCCAGGGGAGAT
GAGGCTGAGAGCAGGGAGTTGAGGCCGAAGAAGTCAAGGCCCCTCCCGCAAATGTGTACCCCTGCCCGCGCCACTGCACCCCGCCGCACC
CCCACCTCCCCCGGGGGCCCTGCTGCGGATGCCGGAGTGGGAGAGTCTCTGAGCTGTGAGATTGATCTTGCCCCTAATTGGAGAGGAAGC
CGGGCGCCAAGACACACGGGGCTCCTGCCTTGGGAGCCAGGGCCGCGGCCGCAGGTAGACCCCAGTAGGGGGGGCCGGGCTCGAAGTTCC
TTTGGGAGGGGCTGGCGGGACTCCAGCAGGCCGTCCTCACCTTTCTTAGAAAGTCCACCCAGGGCAAGTTGATGTTGGGGGAAAGCAGAA
GTCAAGCCAGCCGCGGGCCCCACACGCCCCGACCCGCTCAACCGACTTGTCCCTTAAATGTGTCTTGGATCCCGCAGTGATGACGTGAGC
CAGCCAGGCCCGAAAGGGTGAGGCCAGTGCAGAGAAGCTTCCCAGGGGATTCCTGGGTTCCCCCGAAAGACAAGCGAGGTCATTGCAGTT
CACCTGATGTTGCTCCTGTCCCGTGCGTCCCGGGGAGGCTGTCCTTGGTCCGAGGCTGCTCGTTGCAGCCCCTCCCCTGCTGGCGGTTAC
GATGCGTGGGGTCCCCCTCCCCACCCAGCCCCGGCCACGTCGCCGTGTCCCGCCTGTGCCTGTGACGTCCCTGTGGACCTGTGAGCCATC

>90785_90785_3_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000406797_length(amino acids)=1293AA_BP=1204
MYSLKRRSKSGEKFPAERATALDPGVAAGGMGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYL
WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGE
EGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV
CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMC
INKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV
PCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCP
TECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQE
VVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCN
EHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDW
TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAI
TCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDK
YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKS
CGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH
VEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCV

--------------------------------------------------------------
>90785_90785_4_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000537384_length(transcript)=5277nt_BP=3789nt
ATTCTGCGAGGAATGGCAGCGGCAGCAGCATCCCCGCCAGAGGCGGCGGCGGCGGCGGCAGCGGCCACGGCCACCACCGCGGACGCTATT
GTTCCCTGGTGTTAGACGCGCTCTCCCTCCTTCTCATCTGAAGCGAACAATAGCAGGAAAGAGCTTTGCTTTCTGTACTCTTTGAAAAGA
CGTTCCAAGAGCGGAGAAAAATTCCCTGCCGAGCGTGCTACGGCTCTGGACCCTGGAGTGGCTGCAGGCGGCATGGGGCTGCAAGCCAGG
CGCTGGGCGTCCGGGAGCCGGGGCGCTGCGGGGCCGCGCCGGGGCGTCCTGCAGCTGCTGCCGCTGCCGCTGCCGCTGCCGCTGCTCCTG
CTGCTGCTGCTACGCCCGGGCGCCGGCAGGGCTGCGGCGCAGGGCGAGGCGGAGGCGCCCACCCTCTATCTGTGGAAGACTGGTCCATGG
GGCCGATGTATGGGAGATGAATGTGGTCCCGGAGGCATCCAAACGAGGGCTGTGTGGTGTGCTCATGTGGAGGGATGGACTACACTGCAT
ACTAACTGTAAGCAGGCCGAGAGACCCAATAACCAGCAGAATTGTTTCAAAGTTTGCGATTGGCACAAAGAGTTGTACGACTGGAGACTG
GGACCTTGGAATCAGTGTCAGCCCGTGATTTCAAAAAGCCTAGAGAAACCTCTTGAGTGCATTAAGGGGGAAGAAGGTATTCAGGTGAGG
GAGATAGCGTGCATCCAGAAAGACAAAGACATTCCTGCGGAGGATATCATCTGTGAGTACTTTGAGCCCAAGCCTCTCCTGGAGCAGGCT
TGCCTCATTCCTTGCCAGCAAGATTGCATCGTGTCTGAATTTTCTGCCTGGTCCGAATGCTCCAAGACCTGCGGCAGCGGGCTCCAGCAC
CGGACGCGTCATGTGGTGGCGCCCCCGCAGTTCGGAGGCTCTGGCTGTCCAAACCTGACGGAGTTCCAGGTGTGCCAATCCAGTCCATGC
GAGGCCGAGGAGCTCAGGTACAGCCTGCATGTGGGGCCCTGGAGCACCTGCTCAATGCCCCACTCCCGACAAGTAAGACAAGCAAGGAGA
CGCGGGAAGAATAAAGAACGGGAAAAGGACCGCAGCAAAGGAGTAAAGGATCCAGAAGCCCGCGAGCTTATTAAGAAAAAGAGAAACAGA
AACAGGCAGAACAGACAAGAGAACAAATATTGGGACATCCAGATTGGATATCAGACCAGAGAGGTTATGTGCATTAACAAGACGGGGAAA
GCTGCTGATTTAAGCTTTTGCCAGCAAGAGAAGCTTCCAATGACCTTCCAGTCCTGTGTGATCACCAAAGAGTGCCAGGTTTCCGAGTGG
TCAGAGTGGAGCCCCTGCTCAAAAACATGCCATGACATGGTGTCCCCTGCAGGCACTCGTGTAAGGACACGAACCATCAGGCAGTTTCCC
ATTGGCAGTGAAAAGGAGTGTCCAGAATTTGAAGAAAAAGAACCCTGTTTGTCTCAAGGAGATGGAGTTGTCCCCTGTGCCACGTATGGC
TGGAGAACTACAGAGTGGACTGAGTGCCGTGTGGACCCTTTGCTCAGTCAGCAGGACAAGAGGCGCGGCAACCAGACGGCCCTCTGTGGA
GGGGGCATCCAGACCCGAGAGGTGTACTGCGTGCAGGCCAACGAAAACCTCCTCTCACAATTAAGTACCCACAAGAACAAAGAAGCCTCA
AAGCCAATGGACTTAAAATTATGCACTGGACCTATCCCTAATACTACACAGCTGTGCCACATTCCTTGTCCAACTGAATGTGAAGTTTCA
CCTTGGTCAGCTTGGGGACCTTGTACTTATGAAAACTGTAATGATCAGCAAGGGAAAAAAGGCTTCAAACTGAGGAAGCGGCGCATTACC
AATGAGCCCACTGGAGGCTCTGGGGTAACCGGAAACTGCCCTCACTTACTGGAAGCCATTCCCTGTGAAGAGCCTGCCTGTTATGACTGG
AAAGCAGTGAGACTGGGAAACTGCGAGCCAGATAACGGAAAGGAGTGTGGTCCAGGCACGCAAGTTCAAGAGGTTGTGTGCATCAACAGT
GATGGAGAAGAAGTTGACAGACAGCTGTGCAGAGATGCCATCTTCCCCATCCCTGTGGCCTGTGATGCCCCATGCCCGAAAGACTGTGTG
CTCAGCACATGGTCTACGTGGTCCTCCTGCTCACACACCTGCTCAGGGAAAACGACAGAAGGGAAACAGATACGAGCACGATCCATTCTG
GCCTATGCGGGTGAAGAAGGTGGAATTCGCTGTCCAAATAGCAGTGCTTTGCAAGAAGTACGAAGCTGTAATGAGCATCCTTGCACAGTG
TACCACTGGCAAACTGGTCCCTGGGGCCAGTGCATTGAGGACACCTCAGTATCGTCCTTCAACACAACTACGACTTGGAATGGGGAGGCC
TCCTGCTCTGTCGGCATGCAGACAAGAAAAGTCATCTGTGTGCGAGTCAATGTGGGCCAAGTGGGACCCAAAAAATGTCCTGAAAGCCTT
CGACCTGAAACTGTAAGGCCTTGTCTGCTTCCTTGTAAGAAGGACTGTATTGTGACCCCATATAGTGACTGGACATCATGCCCCTCTTCG
TGTAAAGAAGGGGACTCCAGTATCAGGAAGCAGTCTAGGCATCGGGTCATCATTCAGCTGCCAGCCAACGGGGGCCGAGACTGCACAGAT
CCCCTCTATGAAGAGAAGGCCTGTGAGGCACCTCAAGCGTGCCAAAGCTACAGGTGGAAGACTCACAAATGGCGCAGATGCCAATTAGTC
CCTTGGAGCGTGCAACAAGACAGCCCTGGAGCACAGGAAGGCTGTGGGCCTGGGCGACAGGCAAGAGCCATTACTTGTCGCAAGCAAGAT
GGAGGACAGGCTGGAATCCATGAGTGCCTACAGTATGCAGGCCCTGTGCCAGCCCTTACCCAGGCCTGCCAGATCCCCTGCCAGGATGAC
TGTCAATTGACCAGCTGGTCCAAGTTTTCTTCATGCAATGGAGACTGTGGTGCAGTTAGGACCAGAAAGCGCACTCTTGTTGGAAAAAGT
AAAAAGAAGGAAAAATGTAAAAATTCCCATTTGTATCCCCTGATTGAGACTCAGTATTGTCCTTGTGACAAATATAATGCACAACCTGTG
GGGAACTGGTCAGACTGTATTTTACCAGAGGGAAAAGTGGAAGTGTTGCTGGGAATGAAAGTACAAGGAGACATCAAGGAATGCGGACAA
GGATATCGTTACCAAGCAATGGCATGCTACGATCAAAATGGCAGGCTTGTGGAAACATCTAGATGTAACAGCCATGGTTACATTGAGGAG
GCCTGCATCATCCCCTGCCCCTCAGACTGCAAGCTCAGTGAGTGGTCCAACTGGTCGCGCTGCAGCAAGTCCTGTGGGAGTGGTGTGAAG
GTTCGTTCTAAATGGCTGCGTGAAAAACCATATAATGGAGGAAGGCCTTGCCCCAAACTGGACCATGTCAACCAGGCACAGGTGTATGAG
GTTGTCCCATGCCACAGTGACTGCAACCAGTACCTATGGGTCACAGAGCCCTGGAGCATCTGCAAGGTGACCTTTGTGAATATGCGGGAG
AACTGTGGAGAGGGCGTGCAAACCCGAAAAGTGAGATGCATGCAGAATACAGCAGATGGCCCTTCTGAACATGTAGAGGATTACCTCTGT
GACCCAGAAGAGATGCCCCTGGGCTCTAGAGTGTGCAAATTACCATGCCCTGAGGACTGTGTGATATCTGAATGGGGTCCATGGACCCAA
TGTGTTTTGGGCACCGCGTCCGTGCTGCAGCGCCGGTCCCCCAATGAGGAGTACGTGGAGGTGGGGCGCCTGGGACCCTCTGACTACTTC
GGGGAGATTGCACTGCTGCTGAACCGGCCCCGGGCGGCCACTGTCGTGGCCCGGGGGCCCCTCAAGTGTGTGAAGCTGGACCGGCCCCGC
TTCGAGCGTGTGCTGGGGCCCTGCTCTGAGATCCTCAAGAGGAACATTCAGCGTTACAACAGCTTCATCTCCCTCACCGTCTGAGCACAG
CTCCCGCCCTGCAGCCCCAGCTCCCCAGTGTGGTGGCCGTGCCCTGCTCGTCTGTGTCGGGGGCCCGGGAGCCGCTGTGTGAGGTGTGGG
CCGGGTGGGGCTGGGTCCCGGCAGCGTGAGGACTGCCCCTTCCCCGGACTCACTTTTTGGAATAAATGATCACCTTGTGCATTTCCAAAT
CAAAGGACAAGCGGACAAAATGCATCCCAAGATCAAGGAAGGGACAGGCCAGCTTCCTCCCCACACGCCTCCCCGGCTGCCTCTGTGGGC
TTCTCCTGGGGGGCCCACCCCACCCCTGCCAGTCTCCTGGAGATGCTTGAGGATCGGTCCTCCCCAGAACCAGGCCAGGACGTTGCCCCT
GGGGCCTGGTGACCCTGTGAGGTCAGGTCCCCCAGATTGAGGTCTGAGTGTGGGCAAGTGTGTCAAAAGGGGCTGCCCCCCAGGGGAGAT
GAGGCTGAGAGCAGGGAGTTGAGGCCGAAGAAGTCAAGGCCCCTCCCGCAAATGTGTACCCCTGCCCGCGCCACTGCACCCCGCCGCACC
CCCACCTCCCCCGGGGGCCCTGCTGCGGATGCCGGAGTGGGAGAGTCTCTGAGCTGTGAGATTGATCTTGCCCCTAATTGGAGAGGAAGC
CGGGCGCCAAGACACACGGGGCTCCTGCCTTGGGAGCCAGGGCCGCGGCCGCAGGTAGACCCCAGTAGGGGGGGCCGGGCTCGAAGTTCC
TTTGGGAGGGGCTGGCGGGACTCCAGCAGGCCGTCCTCACCTTTCTTAGAAAGTCCACCCAGGGCAAGTTGATGTTGGGGGAAAGCAGAA
GTCAAGCCAGCCGCGGGCCCCACACGCCCCGACCCGCTCAACCGACTTGTCCCTTAAATGTGTCTTGGATCCCGCAGTGATGACGTGAGC
CAGCCAGGCCCGAAAGGGTGAGGCCAGTGCAGAGAAGCTTCCCAGGGGATTCCTGGGTTCCCCCGAAAGACAAGCGAGGTCATTGCAGTT
CACCTGATGTTGCTCCTGTCCCGTGCGTCCCGGGGAGGCTGTCCTTGGTCCGAGGCTGCTCGTTGCAGCCCCTCCCCTGCTGGCGGTTAC
GATGCGTGGGGTCCCCCTCCCCACCCAGCCCCGGCCACGTCGCCGTGTCCCGCCTGTGCCTGTGACGTCCCTGTGGACCTGTGAGCCATC

>90785_90785_4_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000537384_length(amino acids)=1293AA_BP=1204
MYSLKRRSKSGEKFPAERATALDPGVAAGGMGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYL
WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGE
EGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV
CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMC
INKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV
PCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCP
TECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQE
VVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCN
EHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDW
TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAI
TCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDK
YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKS
CGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH
VEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCV

--------------------------------------------------------------
>90785_90785_5_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000544935_length(transcript)=5277nt_BP=3789nt
ATTCTGCGAGGAATGGCAGCGGCAGCAGCATCCCCGCCAGAGGCGGCGGCGGCGGCGGCAGCGGCCACGGCCACCACCGCGGACGCTATT
GTTCCCTGGTGTTAGACGCGCTCTCCCTCCTTCTCATCTGAAGCGAACAATAGCAGGAAAGAGCTTTGCTTTCTGTACTCTTTGAAAAGA
CGTTCCAAGAGCGGAGAAAAATTCCCTGCCGAGCGTGCTACGGCTCTGGACCCTGGAGTGGCTGCAGGCGGCATGGGGCTGCAAGCCAGG
CGCTGGGCGTCCGGGAGCCGGGGCGCTGCGGGGCCGCGCCGGGGCGTCCTGCAGCTGCTGCCGCTGCCGCTGCCGCTGCCGCTGCTCCTG
CTGCTGCTGCTACGCCCGGGCGCCGGCAGGGCTGCGGCGCAGGGCGAGGCGGAGGCGCCCACCCTCTATCTGTGGAAGACTGGTCCATGG
GGCCGATGTATGGGAGATGAATGTGGTCCCGGAGGCATCCAAACGAGGGCTGTGTGGTGTGCTCATGTGGAGGGATGGACTACACTGCAT
ACTAACTGTAAGCAGGCCGAGAGACCCAATAACCAGCAGAATTGTTTCAAAGTTTGCGATTGGCACAAAGAGTTGTACGACTGGAGACTG
GGACCTTGGAATCAGTGTCAGCCCGTGATTTCAAAAAGCCTAGAGAAACCTCTTGAGTGCATTAAGGGGGAAGAAGGTATTCAGGTGAGG
GAGATAGCGTGCATCCAGAAAGACAAAGACATTCCTGCGGAGGATATCATCTGTGAGTACTTTGAGCCCAAGCCTCTCCTGGAGCAGGCT
TGCCTCATTCCTTGCCAGCAAGATTGCATCGTGTCTGAATTTTCTGCCTGGTCCGAATGCTCCAAGACCTGCGGCAGCGGGCTCCAGCAC
CGGACGCGTCATGTGGTGGCGCCCCCGCAGTTCGGAGGCTCTGGCTGTCCAAACCTGACGGAGTTCCAGGTGTGCCAATCCAGTCCATGC
GAGGCCGAGGAGCTCAGGTACAGCCTGCATGTGGGGCCCTGGAGCACCTGCTCAATGCCCCACTCCCGACAAGTAAGACAAGCAAGGAGA
CGCGGGAAGAATAAAGAACGGGAAAAGGACCGCAGCAAAGGAGTAAAGGATCCAGAAGCCCGCGAGCTTATTAAGAAAAAGAGAAACAGA
AACAGGCAGAACAGACAAGAGAACAAATATTGGGACATCCAGATTGGATATCAGACCAGAGAGGTTATGTGCATTAACAAGACGGGGAAA
GCTGCTGATTTAAGCTTTTGCCAGCAAGAGAAGCTTCCAATGACCTTCCAGTCCTGTGTGATCACCAAAGAGTGCCAGGTTTCCGAGTGG
TCAGAGTGGAGCCCCTGCTCAAAAACATGCCATGACATGGTGTCCCCTGCAGGCACTCGTGTAAGGACACGAACCATCAGGCAGTTTCCC
ATTGGCAGTGAAAAGGAGTGTCCAGAATTTGAAGAAAAAGAACCCTGTTTGTCTCAAGGAGATGGAGTTGTCCCCTGTGCCACGTATGGC
TGGAGAACTACAGAGTGGACTGAGTGCCGTGTGGACCCTTTGCTCAGTCAGCAGGACAAGAGGCGCGGCAACCAGACGGCCCTCTGTGGA
GGGGGCATCCAGACCCGAGAGGTGTACTGCGTGCAGGCCAACGAAAACCTCCTCTCACAATTAAGTACCCACAAGAACAAAGAAGCCTCA
AAGCCAATGGACTTAAAATTATGCACTGGACCTATCCCTAATACTACACAGCTGTGCCACATTCCTTGTCCAACTGAATGTGAAGTTTCA
CCTTGGTCAGCTTGGGGACCTTGTACTTATGAAAACTGTAATGATCAGCAAGGGAAAAAAGGCTTCAAACTGAGGAAGCGGCGCATTACC
AATGAGCCCACTGGAGGCTCTGGGGTAACCGGAAACTGCCCTCACTTACTGGAAGCCATTCCCTGTGAAGAGCCTGCCTGTTATGACTGG
AAAGCAGTGAGACTGGGAAACTGCGAGCCAGATAACGGAAAGGAGTGTGGTCCAGGCACGCAAGTTCAAGAGGTTGTGTGCATCAACAGT
GATGGAGAAGAAGTTGACAGACAGCTGTGCAGAGATGCCATCTTCCCCATCCCTGTGGCCTGTGATGCCCCATGCCCGAAAGACTGTGTG
CTCAGCACATGGTCTACGTGGTCCTCCTGCTCACACACCTGCTCAGGGAAAACGACAGAAGGGAAACAGATACGAGCACGATCCATTCTG
GCCTATGCGGGTGAAGAAGGTGGAATTCGCTGTCCAAATAGCAGTGCTTTGCAAGAAGTACGAAGCTGTAATGAGCATCCTTGCACAGTG
TACCACTGGCAAACTGGTCCCTGGGGCCAGTGCATTGAGGACACCTCAGTATCGTCCTTCAACACAACTACGACTTGGAATGGGGAGGCC
TCCTGCTCTGTCGGCATGCAGACAAGAAAAGTCATCTGTGTGCGAGTCAATGTGGGCCAAGTGGGACCCAAAAAATGTCCTGAAAGCCTT
CGACCTGAAACTGTAAGGCCTTGTCTGCTTCCTTGTAAGAAGGACTGTATTGTGACCCCATATAGTGACTGGACATCATGCCCCTCTTCG
TGTAAAGAAGGGGACTCCAGTATCAGGAAGCAGTCTAGGCATCGGGTCATCATTCAGCTGCCAGCCAACGGGGGCCGAGACTGCACAGAT
CCCCTCTATGAAGAGAAGGCCTGTGAGGCACCTCAAGCGTGCCAAAGCTACAGGTGGAAGACTCACAAATGGCGCAGATGCCAATTAGTC
CCTTGGAGCGTGCAACAAGACAGCCCTGGAGCACAGGAAGGCTGTGGGCCTGGGCGACAGGCAAGAGCCATTACTTGTCGCAAGCAAGAT
GGAGGACAGGCTGGAATCCATGAGTGCCTACAGTATGCAGGCCCTGTGCCAGCCCTTACCCAGGCCTGCCAGATCCCCTGCCAGGATGAC
TGTCAATTGACCAGCTGGTCCAAGTTTTCTTCATGCAATGGAGACTGTGGTGCAGTTAGGACCAGAAAGCGCACTCTTGTTGGAAAAAGT
AAAAAGAAGGAAAAATGTAAAAATTCCCATTTGTATCCCCTGATTGAGACTCAGTATTGTCCTTGTGACAAATATAATGCACAACCTGTG
GGGAACTGGTCAGACTGTATTTTACCAGAGGGAAAAGTGGAAGTGTTGCTGGGAATGAAAGTACAAGGAGACATCAAGGAATGCGGACAA
GGATATCGTTACCAAGCAATGGCATGCTACGATCAAAATGGCAGGCTTGTGGAAACATCTAGATGTAACAGCCATGGTTACATTGAGGAG
GCCTGCATCATCCCCTGCCCCTCAGACTGCAAGCTCAGTGAGTGGTCCAACTGGTCGCGCTGCAGCAAGTCCTGTGGGAGTGGTGTGAAG
GTTCGTTCTAAATGGCTGCGTGAAAAACCATATAATGGAGGAAGGCCTTGCCCCAAACTGGACCATGTCAACCAGGCACAGGTGTATGAG
GTTGTCCCATGCCACAGTGACTGCAACCAGTACCTATGGGTCACAGAGCCCTGGAGCATCTGCAAGGTGACCTTTGTGAATATGCGGGAG
AACTGTGGAGAGGGCGTGCAAACCCGAAAAGTGAGATGCATGCAGAATACAGCAGATGGCCCTTCTGAACATGTAGAGGATTACCTCTGT
GACCCAGAAGAGATGCCCCTGGGCTCTAGAGTGTGCAAATTACCATGCCCTGAGGACTGTGTGATATCTGAATGGGGTCCATGGACCCAA
TGTGTTTTGGGCACCGCGTCCGTGCTGCAGCGCCGGTCCCCCAATGAGGAGTACGTGGAGGTGGGGCGCCTGGGACCCTCTGACTACTTC
GGGGAGATTGCACTGCTGCTGAACCGGCCCCGGGCGGCCACTGTCGTGGCCCGGGGGCCCCTCAAGTGTGTGAAGCTGGACCGGCCCCGC
TTCGAGCGTGTGCTGGGGCCCTGCTCTGAGATCCTCAAGAGGAACATTCAGCGTTACAACAGCTTCATCTCCCTCACCGTCTGAGCACAG
CTCCCGCCCTGCAGCCCCAGCTCCCCAGTGTGGTGGCCGTGCCCTGCTCGTCTGTGTCGGGGGCCCGGGAGCCGCTGTGTGAGGTGTGGG
CCGGGTGGGGCTGGGTCCCGGCAGCGTGAGGACTGCCCCTTCCCCGGACTCACTTTTTGGAATAAATGATCACCTTGTGCATTTCCAAAT
CAAAGGACAAGCGGACAAAATGCATCCCAAGATCAAGGAAGGGACAGGCCAGCTTCCTCCCCACACGCCTCCCCGGCTGCCTCTGTGGGC
TTCTCCTGGGGGGCCCACCCCACCCCTGCCAGTCTCCTGGAGATGCTTGAGGATCGGTCCTCCCCAGAACCAGGCCAGGACGTTGCCCCT
GGGGCCTGGTGACCCTGTGAGGTCAGGTCCCCCAGATTGAGGTCTGAGTGTGGGCAAGTGTGTCAAAAGGGGCTGCCCCCCAGGGGAGAT
GAGGCTGAGAGCAGGGAGTTGAGGCCGAAGAAGTCAAGGCCCCTCCCGCAAATGTGTACCCCTGCCCGCGCCACTGCACCCCGCCGCACC
CCCACCTCCCCCGGGGGCCCTGCTGCGGATGCCGGAGTGGGAGAGTCTCTGAGCTGTGAGATTGATCTTGCCCCTAATTGGAGAGGAAGC
CGGGCGCCAAGACACACGGGGCTCCTGCCTTGGGAGCCAGGGCCGCGGCCGCAGGTAGACCCCAGTAGGGGGGGCCGGGCTCGAAGTTCC
TTTGGGAGGGGCTGGCGGGACTCCAGCAGGCCGTCCTCACCTTTCTTAGAAAGTCCACCCAGGGCAAGTTGATGTTGGGGGAAAGCAGAA
GTCAAGCCAGCCGCGGGCCCCACACGCCCCGACCCGCTCAACCGACTTGTCCCTTAAATGTGTCTTGGATCCCGCAGTGATGACGTGAGC
CAGCCAGGCCCGAAAGGGTGAGGCCAGTGCAGAGAAGCTTCCCAGGGGATTCCTGGGTTCCCCCGAAAGACAAGCGAGGTCATTGCAGTT
CACCTGATGTTGCTCCTGTCCCGTGCGTCCCGGGGAGGCTGTCCTTGGTCCGAGGCTGCTCGTTGCAGCCCCTCCCCTGCTGGCGGTTAC
GATGCGTGGGGTCCCCCTCCCCACCCAGCCCCGGCCACGTCGCCGTGTCCCGCCTGTGCCTGTGACGTCCCTGTGGACCTGTGAGCCATC

>90785_90785_5_THSD7A-PRKAR1B_THSD7A_chr7_11457077_ENST00000423059_PRKAR1B_chr7_591107_ENST00000544935_length(amino acids)=1293AA_BP=1204
MYSLKRRSKSGEKFPAERATALDPGVAAGGMGLQARRWASGSRGAAGPRRGVLQLLPLPLPLPLLLLLLLRPGAGRAAAQGEAEAPTLYL
WKTGPWGRCMGDECGPGGIQTRAVWCAHVEGWTTLHTNCKQAERPNNQQNCFKVCDWHKELYDWRLGPWNQCQPVISKSLEKPLECIKGE
EGIQVREIACIQKDKDIPAEDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNLTEFQV
CQSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEARELIKKKRNRNRQNRQENKYWDIQIGYQTREVMC
INKTGKAADLSFCQQEKLPMTFQSCVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV
PCATYGWRTTEWTECRVDPLLSQQDKRRGNQTALCGGGIQTREVYCVQANENLLSQLSTHKNKEASKPMDLKLCTGPIPNTTQLCHIPCP
TECEVSPWSAWGPCTYENCNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPHLLEAIPCEEPACYDWKAVRLGNCEPDNGKECGPGTQVQE
VVCINSDGEEVDRQLCRDAIFPIPVACDAPCPKDCVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCN
EHPCTVYHWQTGPWGQCIEDTSVSSFNTTTTWNGEASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLPCKKDCIVTPYSDW
TSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWKTHKWRRCQLVPWSVQQDSPGAQEGCGPGRQARAI
TCRKQDGGQAGIHECLQYAGPVPALTQACQIPCQDDCQLTSWSKFSSCNGDCGAVRTRKRTLVGKSKKKEKCKNSHLYPLIETQYCPCDK
YNAQPVGNWSDCILPEGKVEVLLGMKVQGDIKECGQGYRYQAMACYDQNGRLVETSRCNSHGYIEEACIIPCPSDCKLSEWSNWSRCSKS
CGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEH
VEDYLCDPEEMPLGSRVCKLPCPEDCVISEWGPWTQCVLGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for THSD7A-PRKAR1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THSD7A-PRKAR1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THSD7A-PRKAR1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource