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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:THUMPD2-MAP4K3 (FusionGDB2 ID:90804)

Fusion Gene Summary for THUMPD2-MAP4K3

check button Fusion gene summary
Fusion gene informationFusion gene name: THUMPD2-MAP4K3
Fusion gene ID: 90804
HgeneTgene
Gene symbol

THUMPD2

MAP4K3

Gene ID

80745

8491

Gene nameTHUMP domain containing 2mitogen-activated protein kinase kinase kinase kinase 3
SynonymsC2orf8GLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1
Cytomap

2p22.1|2p22-p21

2p22.1

Type of geneprotein-codingprotein-coding
DescriptionTHUMP domain-containing protein 2SAM-dependent methyltransferaseepididymis secretory sperm binding proteinmitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinase
Modification date2020031320200313
UniProtAcc.

Q8IVH8

Ensembl transtripts involved in fusion geneENST00000260619, ENST00000454352, 
ENST00000505747, ENST00000403537, 
ENST00000536018, ENST00000474502, 
ENST00000484274, ENST00000263881, 
ENST00000341681, ENST00000437545, 
Fusion gene scores* DoF score5 X 4 X 4=808 X 8 X 7=448
# samples 611
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/448*10)=-2.02599520853294
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: THUMPD2 [Title/Abstract] AND MAP4K3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTHUMPD2(40006254)-MAP4K3(39542529), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAP4K3

GO:0006468

protein phosphorylation

9275185

TgeneMAP4K3

GO:0009411

response to UV

9275185

TgeneMAP4K3

GO:0034612

response to tumor necrosis factor

9275185

TgeneMAP4K3

GO:0035556

intracellular signal transduction

9275185


check buttonFusion gene breakpoints across THUMPD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP4K3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8683-01ATHUMPD2chr2

40006254

-MAP4K3chr2

39542529

-


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Fusion Gene ORF analysis for THUMPD2-MAP4K3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000260619ENST00000536018THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5CDS-5UTRENST00000454352ENST00000536018THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5CDS-5UTRENST00000505747ENST00000536018THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5CDS-intronENST00000260619ENST00000474502THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5CDS-intronENST00000260619ENST00000484274THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5CDS-intronENST00000454352ENST00000474502THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5CDS-intronENST00000454352ENST00000484274THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5CDS-intronENST00000505747ENST00000474502THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5CDS-intronENST00000505747ENST00000484274THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5UTR-3CDSENST00000403537ENST00000263881THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5UTR-3CDSENST00000403537ENST00000341681THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5UTR-3CDSENST00000403537ENST00000437545THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5UTR-5UTRENST00000403537ENST00000536018THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5UTR-intronENST00000403537ENST00000474502THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
5UTR-intronENST00000403537ENST00000484274THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
In-frameENST00000260619ENST00000263881THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
In-frameENST00000260619ENST00000341681THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
In-frameENST00000260619ENST00000437545THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
In-frameENST00000454352ENST00000263881THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
In-frameENST00000454352ENST00000341681THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
In-frameENST00000454352ENST00000437545THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
In-frameENST00000505747ENST00000263881THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
In-frameENST00000505747ENST00000341681THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-
In-frameENST00000505747ENST00000437545THUMPD2chr2

40006254

-MAP4K3chr2

39542529

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000505747THUMPD2chr240006254-ENST00000263881MAP4K3chr239542529-3273154281920630
ENST00000505747THUMPD2chr240006254-ENST00000437545MAP4K3chr239542529-3198154281857609
ENST00000505747THUMPD2chr240006254-ENST00000341681MAP4K3chr239542529-3193154281857609
ENST00000260619THUMPD2chr240006254-ENST00000263881MAP4K3chr239542529-31553601802600
ENST00000260619THUMPD2chr240006254-ENST00000437545MAP4K3chr239542529-30803601739579
ENST00000260619THUMPD2chr240006254-ENST00000341681MAP4K3chr239542529-30753601739579
ENST00000454352THUMPD2chr240006254-ENST00000263881MAP4K3chr239542529-31583931805600
ENST00000454352THUMPD2chr240006254-ENST00000437545MAP4K3chr239542529-30833931742579
ENST00000454352THUMPD2chr240006254-ENST00000341681MAP4K3chr239542529-30783931742579

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000505747ENST00000263881THUMPD2chr240006254-MAP4K3chr239542529-0.0002458090.99975413
ENST00000505747ENST00000437545THUMPD2chr240006254-MAP4K3chr239542529-0.000625320.9993747
ENST00000505747ENST00000341681THUMPD2chr240006254-MAP4K3chr239542529-0.0006124570.9993875
ENST00000260619ENST00000263881THUMPD2chr240006254-MAP4K3chr239542529-0.0002458050.99975425
ENST00000260619ENST00000437545THUMPD2chr240006254-MAP4K3chr239542529-0.0002303910.9997696
ENST00000260619ENST00000341681THUMPD2chr240006254-MAP4K3chr239542529-0.0002225930.9997774
ENST00000454352ENST00000263881THUMPD2chr240006254-MAP4K3chr239542529-0.0002414680.99975854
ENST00000454352ENST00000437545THUMPD2chr240006254-MAP4K3chr239542529-0.0002256650.9997744
ENST00000454352ENST00000341681THUMPD2chr240006254-MAP4K3chr239542529-0.000218010.999782

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Fusion Genomic Features for THUMPD2-MAP4K3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for THUMPD2-MAP4K3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:40006254/chr2:39542529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP4K3

Q8IVH8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAP4K3chr2:40006254chr2:39542529ENST000002638811134556_867306895.0DomainCNH
TgeneMAP4K3chr2:40006254chr2:39542529ENST000003416811133556_867306874.0DomainCNH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTHUMPD2chr2:40006254chr2:39542529ENST00000260619-110161_26612474.0DomainTHUMP
HgeneTHUMPD2chr2:40006254chr2:39542529ENST00000505747-110161_26642504.0DomainTHUMP
TgeneMAP4K3chr2:40006254chr2:39542529ENST00000263881113416_273306895.0DomainProtein kinase
TgeneMAP4K3chr2:40006254chr2:39542529ENST00000341681113316_273306874.0DomainProtein kinase
TgeneMAP4K3chr2:40006254chr2:39542529ENST00000263881113422_30306895.0Nucleotide bindingATP
TgeneMAP4K3chr2:40006254chr2:39542529ENST00000341681113322_30306874.0Nucleotide bindingATP


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Fusion Gene Sequence for THUMPD2-MAP4K3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90804_90804_1_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000260619_MAP4K3_chr2_39542529_ENST00000263881_length(transcript)=3155nt_BP=36nt
ATGCGAGAGGTGCGGGCGCGGCTGGCGGCCACGCAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAA
GAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCCGAC
AGTGATGGTTTTTTGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACACCAA
GGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGAT
GATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATA
CCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTT
CCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGA
GATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAAT
GGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCA
TGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACA
TCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTT
TATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGA
ATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGC
CATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATA
GATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGA
GGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACA
AATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTA
AAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGG
AAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCT
GACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTAC
TGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTG
CAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGC
ATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAG
ACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAAT
GCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACAT
TTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATT
TTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGC
TGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGT
AGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAG
AATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTA
AACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCT
TATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAA
TGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGC
AAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATG
ATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAATAAACATGTTTTTTAACATGCTGTTGTA

>90804_90804_1_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000260619_MAP4K3_chr2_39542529_ENST00000263881_length(amino acids)=600AA_BP=12
MREVRARLAATQPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQ
GGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQV
PPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASS
WINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDR
ILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSR
GRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFW

--------------------------------------------------------------
>90804_90804_2_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000260619_MAP4K3_chr2_39542529_ENST00000341681_length(transcript)=3075nt_BP=36nt
ATGCGAGAGGTGCGGGCGCGGCTGGCGGCCACGCAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAA
GAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATCTG
CAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAG
CGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTG
CCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCA
GGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATG
AGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAG
AAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGT
CCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACC
CTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTA
TCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCT
ATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGT
TGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATG
CAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTAC
CCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGG
TTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATA
AAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGC
CTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGC
ACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTAC
ATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAA
TGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTT
GTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTT
TTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATC
TGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAA
TGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTT
AAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATAT
GTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCA
AACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACA
ATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTA
ATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTC
TCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTT
AGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAA
TGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACAC
TAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAAT

>90804_90804_2_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000260619_MAP4K3_chr2_39542529_ENST00000341681_length(amino acids)=579AA_BP=12
MREVRARLAATQPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQ
RGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGM
SSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYT
LNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKC
CVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSW
FTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDS

--------------------------------------------------------------
>90804_90804_3_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000260619_MAP4K3_chr2_39542529_ENST00000437545_length(transcript)=3080nt_BP=36nt
ATGCGAGAGGTGCGGGCGCGGCTGGCGGCCACGCAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGAGAA
GAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGATCTG
CAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAG
CGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTG
CCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCA
GGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATG
AGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAG
AAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGT
CCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACC
CTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTA
TCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCT
ATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGT
TGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATG
CAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTAC
CCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGG
TTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATA
AAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGC
CTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGC
ACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTAC
ATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAA
TGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTT
GTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTT
TTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATC
TGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAA
TGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTT
AAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATAT
GTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCA
AACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACA
ATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTA
ATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTC
TCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTT
AGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAA
TGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACAC
TAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAAT

>90804_90804_3_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000260619_MAP4K3_chr2_39542529_ENST00000437545_length(amino acids)=579AA_BP=12
MREVRARLAATQPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQ
RGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGM
SSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYT
LNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKC
CVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSW
FTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDS

--------------------------------------------------------------
>90804_90804_4_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000454352_MAP4K3_chr2_39542529_ENST00000263881_length(transcript)=3158nt_BP=39nt
GTAATGCGAGAGGTGCGGGCGCGGCTGGCGGCCACGCAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGA
GAAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTCCC
GACAGTGATGGTTTTTTGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCTGCAACTGGAATATGGACAAGGACAC
CAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAA
GATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTC
ATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAA
GTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAA
CGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGT
AATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCA
TCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAA
ACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAG
CTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGAC
AGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACG
GGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCAC
ATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGT
AGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAG
ACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGA
TTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTC
TGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGA
TCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGT
TACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAG
CTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTT
AGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTG
AAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAA
AATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATA
CATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATC
ATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTA
AGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGT
TGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCA
CAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCA
CTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGG
CCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATA
TAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTT
AGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTT
ATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAATAAACATGTTTTTTAACATGCTGTT

>90804_90804_4_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000454352_MAP4K3_chr2_39542529_ENST00000263881_length(amino acids)=600AA_BP=12
MREVRARLAATQPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQ
GGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQV
PPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASS
WINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDR
ILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSR
GRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFW

--------------------------------------------------------------
>90804_90804_5_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000454352_MAP4K3_chr2_39542529_ENST00000341681_length(transcript)=3078nt_BP=39nt
GTAATGCGAGAGGTGCGGGCGCGGCTGGCGGCCACGCAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGA
GAAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGAT
CTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCAT
CAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCT
TTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATG
TCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGA
ATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAA
AAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGG
TGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTAT
ACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTG
CTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTT
GCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAG
TGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCA
ATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAG
TACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCA
TGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGT
ATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTG
TGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGAT
AGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTG
TACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACAT
TAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAAT
TTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTA
TTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTT
ATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACA
AAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACT
TTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGA
TATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAA
GCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAA
ACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAA
TTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAAT
TTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAA
TTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTC
CAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATA
CACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAA

>90804_90804_5_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000454352_MAP4K3_chr2_39542529_ENST00000341681_length(amino acids)=579AA_BP=12
MREVRARLAATQPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQ
RGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGM
SSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYT
LNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKC
CVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSW
FTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDS

--------------------------------------------------------------
>90804_90804_6_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000454352_MAP4K3_chr2_39542529_ENST00000437545_length(transcript)=3083nt_BP=39nt
GTAATGCGAGAGGTGCGGGCGCGGCTGGCGGCCACGCAGCCTCTTGTTGCTGTACCACATAGAATTCACTCAACAAGTAGAAACGTGAGA
GAAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGAGACAGAACCACATCATGAACTTGAT
CTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCAT
CAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCT
TTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATG
TCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGA
ATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAA
AAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGG
TGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTAT
ACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTG
CTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTT
GCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAG
TGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCA
ATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAG
TACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCA
TGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGT
ATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTG
TGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGAT
AGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTG
TACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACAT
TAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAAT
TTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTA
TTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTT
ATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACA
AAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACT
TTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGA
TATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAA
GCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAA
ACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAA
TTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAAT
TTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAA
TTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTC
CAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATA
CACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAA

>90804_90804_6_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000454352_MAP4K3_chr2_39542529_ENST00000437545_length(amino acids)=579AA_BP=12
MREVRARLAATQPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQ
RGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGM
SSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYT
LNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKC
CVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSW
FTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDS

--------------------------------------------------------------
>90804_90804_7_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000505747_MAP4K3_chr2_39542529_ENST00000263881_length(transcript)=3273nt_BP=154nt
GAAGGCGCGAGGGCGCGCCTGAGCCGCCATGTCGGAGGCGCGTGGAGAGCCAGGGTCCGGGCCTGAGGCTGGCGCCCGATTCTTCTGCAC
TGCGGGTCGCGGCCTGGAGCCGTTCGTAATGCGAGAGGTGCGGGCGCGGCTGGCGGCCACGCAGCCTCTTGTTGCTGTACCACATAGAAT
TCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGA
GACAGAACCACATCATGAACTTCCCGACAGTGATGGTTTTTTGGACAGTTCAGAAGAAATATACTACACTGCAAGATCTAATCTGGATCT
GCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCTCAAGTCTGTTGAAGAAGAATTGCATCA
GCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAACTCTGAAAGCAAAAATTCCACCTCCTTT
GCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCAAGGAACAATCAAGAGATGTCCCATGTC
AGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACACAAACCTGTTGCCTTAGGAAATGGAAT
GAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAGAGGCACAAACCTTTCAAGAAAAGAAAA
GAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGCATGTTTTTCAAAAGTTTTTAATGGGTG
TCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGATATTTGGTGCCGAAGAAGGGATTTATAC
CCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATGGTTGTATGTAATGAACAATTGCTTGCT
ATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGCAAGACAAATGCAAAAGTTACCTGTTGC
TATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAATCCCTGAAACCAAATGGTGCCAGAAGTG
TTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCATTGTTCTATTAGAATGGGTTGAACCAAT
GCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGAAATGCTGGTAGTTCCTGAACAGGAGTA
CCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGACGGTCAATCCAAATTCTACCTCTTCATG
GTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATACCATCCTTGTATGCTTGGACTGTTGTAT
AAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTTTGATTTCCAGATTGAATCAATAGTGTG
CCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAATGAGGTAACACAAGAAATTTCAGATAG
CACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGATAACCCCACAGCAAATAGCAATTTGTA
CATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAAAGAAAGAACACTACCACTGCAACATTA
ATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTGTGGCATGAGATAAGATGGGGAAAATTT
TGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTATGTAATCTTTGTACATATAGGCAGTATT
TTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTTTATGAGATGTACAAGTAAGTGTCTTAT
CTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTATATTCTTGGGTGTGGCTATATTACAAA
ATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAGTAATATGAATATAAATCTTGTAACTTT
TAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGGTGTTTATATTTGCACAAAGTATTGATA
TGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAATGTATTTGGATTGTTTTCTATGTGAAGC
AAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTGTAAGATTGCTTGTCTTTGCTTAAAAAC
AATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGGTCAGAATTACAGTATGCACAAAGAATT
AATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACATTCCATAGAGTGAAGTGGTTCAAATTT
CTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTAGAGTATTAATACATGGCCAAAATAATT
TAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTTTAAGTCATTTTTGATTGCTTTTTTCCA
ATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTTCTTTATATTTTAATGTGAGTATATACA
CTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAATATGTTCCTGATTGTACATATTGTAAAA

>90804_90804_7_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000505747_MAP4K3_chr2_39542529_ENST00000263881_length(amino acids)=630AA_BP=0
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPD
SDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFI
PQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISN
GLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQL
YSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHI
DFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRL
KSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY

--------------------------------------------------------------
>90804_90804_8_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000505747_MAP4K3_chr2_39542529_ENST00000341681_length(transcript)=3193nt_BP=154nt
GAAGGCGCGAGGGCGCGCCTGAGCCGCCATGTCGGAGGCGCGTGGAGAGCCAGGGTCCGGGCCTGAGGCTGGCGCCCGATTCTTCTGCAC
TGCGGGTCGCGGCCTGGAGCCGTTCGTAATGCGAGAGGTGCGGGCGCGGCTGGCGGCCACGCAGCCTCTTGTTGCTGTACCACATAGAAT
TCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGA
GACAGAACCACATCATGAACTTGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCT
CAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAAC
TCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCA
AGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACA
CAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAG
AGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGC
ATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGAT
ATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATG
GTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGC
AAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAAT
CCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCAT
TGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGA
AATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGAC
GGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATAC
CATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTT
TGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAA
TGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGA
TAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAA
AGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTG
TGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTAT
GTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTT
TATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTA
TATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAG
TAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGG
TGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAAT
GTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTG
TAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGG
TCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACA
TTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTA
GAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTT
TAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTT
CTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAAT

>90804_90804_8_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000505747_MAP4K3_chr2_39542529_ENST00000341681_length(amino acids)=609AA_BP=0
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDL
QLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMS
GSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGC
PLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVA
IPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEY
PLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVC

--------------------------------------------------------------
>90804_90804_9_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000505747_MAP4K3_chr2_39542529_ENST00000437545_length(transcript)=3198nt_BP=154nt
GAAGGCGCGAGGGCGCGCCTGAGCCGCCATGTCGGAGGCGCGTGGAGAGCCAGGGTCCGGGCCTGAGGCTGGCGCCCGATTCTTCTGCAC
TGCGGGTCGCGGCCTGGAGCCGTTCGTAATGCGAGAGGTGCGGGCGCGGCTGGCGGCCACGCAGCCTCTTGTTGCTGTACCACATAGAAT
TCACTCAACAAGTAGAAACGTGAGAGAAGAAAAAACACGCTCAGAGATAACCTTTGGCCAAGTGAAATTTGATCCACCCTTAAGAAAGGA
GACAGAACCACATCATGAACTTGATCTGCAACTGGAATATGGACAAGGACACCAAGGTGGTTACTTTTTAGGTGCAAACAAGAGTCTTCT
CAAGTCTGTTGAAGAAGAATTGCATCAGCGAGGACACGTCGCACATTTAGAAGATGATGAAGGAGATGATGATGAATCTAAACACTCAAC
TCTGAAAGCAAAAATTCCACCTCCTTTGCCACCAAAGCCTAAGTCTATCTTCATACCACAGGAAATGCATTCTACTGAGGATGAAAATCA
AGGAACAATCAAGAGATGTCCCATGTCAGGGAGCCCAGCAAAGCCATCCCAAGTTCCACCTAGACCACCACCTCCCAGATTACCCCCACA
CAAACCTGTTGCCTTAGGAAATGGAATGAGCTCCTTCCAGTTAAATGGTGAACGAGATGGCTCATTATGTCAACAACAGAATGAACATAG
AGGCACAAACCTTTCAAGAAAAGAAAAGAAAGATGTACCAAAGCCTATTAGTAATGGTCTTCCTCCAACACCTAAAGTGCATATGGGTGC
ATGTTTTTCAAAAGTTTTTAATGGGTGTCCCTTGAAAATTCACTGTGCATCATCATGGATAAACCCAGATACAAGAGATCAGTACTTGAT
ATTTGGTGCCGAAGAAGGGATTTATACCCTCAATCTTAATGAACTTCATGAAACATCAATGGAACAGCTATTCCCTCGAAGGTGTACATG
GTTGTATGTAATGAACAATTGCTTGCTATCAATATCTGGTAAAGCTTCTCAGCTTTATTCCCATAATTTACCAGGGCTTTTTGATTATGC
AAGACAAATGCAAAAGTTACCTGTTGCTATTCCAGCACACAAACTCCCTGACAGAATACTGCCAAGGAAATTTTCTGTATCAGCAAAAAT
CCCTGAAACCAAATGGTGCCAGAAGTGTTGTGTTGTAAGAAATCCTTACACGGGCCATAAATACCTATGTGGAGCACTTCAGACTAGCAT
TGTTCTATTAGAATGGGTTGAACCAATGCAGAAATTTATGTTAATTAAGCACATAGATTTTCCTATACCATGTCCACTTAGAATGTTTGA
AATGCTGGTAGTTCCTGAACAGGAGTACCCTTTAGTTTGTGTTGGTGTCAGTAGAGGTAGAGACTTCAACCAAGTGGTTCGATTTGAGAC
GGTCAATCCAAATTCTACCTCTTCATGGTTTACAGAATCAGATACCCCACAGACAAATGTTACTCATGTAACCCAACTGGAGAGAGATAC
CATCCTTGTATGCTTGGACTGTTGTATAAAAATAGTAAATCTCCAAGGAAGATTAAAATCTAGCAGGAAATTGTCATCAGAACTCACCTT
TGATTTCCAGATTGAATCAATAGTGTGCCTACAAGACAGTGTGCTAGCTTTCTGGAAACATGGAATGCAAGGTAGAAGTTTTAGATCTAA
TGAGGTAACACAAGAAATTTCAGATAGCACAAGAATTTTCAGGCTGCTTGGATCTGACAGGGTCGTGGTTTTGGAAAGTAGGCCAACTGA
TAACCCCACAGCAAATAGCAATTTGTACATCCTGGCGGGTCATGAAAACAGTTACTGAGAATTGTTGTGCTTTGACAGTTAACTCTAGAA
AGAAAGAACACTACCACTGCAACATTAATGGATGCTTGAAGCTGTACAAAAGCTGCAGTAACCTGTCTTCAGTTACTTTGTAATTTATTG
TGGCATGAGATAAGATGGGGAAAATTTTGTTTTAAGTGGTATGGATATATTTAGCATATTGAACCACACAAGTGCTTAATTCATTGTTAT
GTAATCTTTGTACATATAGGCAGTATTTTTTCTGTGAAACTTCATATTGCTGAAGACATACACTAAGAATTTATGTAGATAATGTACTTT
TATGAGATGTACAAGTAAGTGTCTTATCTGTACAGATGTAAATGTTGATGAAAATGCAATTGGGGTTAATATTTTAAGAATTCTTTAGTA
TATTCTTGGGTGTGGCTATATTACAAAATGGGATGCTGGCAATGAAACAATACATTTAACACTATTGTATTTTTATTATATGTAATTTAG
TAATATGAATATAAATCTTGTAACTTTTAAAATTGTAATGGAGGCTGTAATCATTTTATAATCTTTTTAATTTTAATGCAAGTACACTGG
TGTTTATATTTGCACAAAGTATTGATATGTGATGTATTAAGTCACAAAAGTAAGCTGTGACATTGTCTATAAGCATTTGGCTCCACAAAT
GTATTTGGATTGTTTTCTATGTGAAGCAAACCAATTATAATTAACCACATGTTGTAGTAACTGGTCTTTTTATATTTAAGCAGAATCCTG
TAAGATTGCTTGTCTTTGCTTAAAAACAATACCTTTGAACATTTTTGAATCACAGAATAGCGGTACCATGATAGAATACTGCAATTGTGG
TCAGAATTACAGTATGCACAAAGAATTAATTAGCATTATTAAAGAGTCCTCACTAAACATTTCATATGATCACACTGAAGAACTGTAACA
TTCCATAGAGTGAAGTGGTTCAAATTTCTCTTGGAATTTTTACTTTTGTTGGCCTTATTTTATGATCCTTTTCATATTTCTTTTGACTTA
GAGTATTAATACATGGCCAAAATAATTTAGTTACTACCTCATACAAACAATATAATGGTTACTACACATCACAGGAACTTAGTTTTGGTT
TAAGTCATTTTTGATTGCTTTTTTCCAATGGAATATGTATATACCAGGTTTTAGCAAAATGCACACTTTTGGCTCTTTTTGGTATATGTT
CTTTATATTTTAATGTGAGTATATACACTAAGAACAAACTAAATTGTGATTTATGATCTTCATTTATTTTAATGATAATGGTTTTAAAAT

>90804_90804_9_THUMPD2-MAP4K3_THUMPD2_chr2_40006254_ENST00000505747_MAP4K3_chr2_39542529_ENST00000437545_length(amino acids)=609AA_BP=0
MSEARGEPGSGPEAGARFFCTAGRGLEPFVMREVRARLAATQPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELDL
QLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMS
GSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGC
PLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVA
IPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEY
PLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for THUMPD2-MAP4K3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for THUMPD2-MAP4K3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for THUMPD2-MAP4K3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource