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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TIAL1-SEC23IP (FusionGDB2 ID:90836)

Fusion Gene Summary for TIAL1-SEC23IP

Fusion gene summary

Fusion gene information	Fusion gene name: TIAL1-SEC23IP
	Fusion gene ID: 90836
		Hgene	Tgene
	Gene symbol	TIAL1	SEC23IP
	Gene ID	7073	11196
	Gene name	TIA1 cytotoxic granule associated RNA binding protein like 1	SEC23 interacting protein
	Synonyms	TCBP\|TIAR	MSTP053\|P125\|P125A
	Cytomap	10q26.11	10q26.11-q26.12
	Type of gene	protein-coding	protein-coding
	Description	nucleolysin TIART-cluster binding proteinTIA-1-related nucleolysinTIA1 relatedaging-associated gene 7 protein	SEC23-interacting protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000369093, ENST00000436547, ENST00000369092, ENST00000463089,	ENST00000475542, ENST00000369075, ENST00000543134,
Fusion gene scores	* DoF score	9 X 9 X 5=405	7 X 9 X 4=252
	# samples	9	7
	** MAII score	log2(9/405*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TIAL1 [Title/Abstract] AND SEC23IP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TIAL1(121355945)-SEC23IP(121685547), # samples:1 TIAL1(121355946)-SEC23IP(121685548), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TIAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC23IP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-BH-A0BJ-11A	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
ChimerDB4	Non-Cancer	TCGA-BH-A0BJ-11A	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+

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Fusion Gene ORF analysis for TIAL1-SEC23IP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000369093	ENST00000475542	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
5CDS-intron	ENST00000369093	ENST00000475542	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
5CDS-intron	ENST00000436547	ENST00000475542	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
5CDS-intron	ENST00000436547	ENST00000475542	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
5UTR-3CDS	ENST00000369092	ENST00000369075	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
5UTR-3CDS	ENST00000369092	ENST00000369075	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
5UTR-3CDS	ENST00000369092	ENST00000543134	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
5UTR-3CDS	ENST00000369092	ENST00000543134	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
5UTR-intron	ENST00000369092	ENST00000475542	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
5UTR-intron	ENST00000369092	ENST00000475542	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
In-frame	ENST00000369093	ENST00000369075	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
In-frame	ENST00000369093	ENST00000369075	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
In-frame	ENST00000369093	ENST00000543134	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
In-frame	ENST00000369093	ENST00000543134	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
In-frame	ENST00000436547	ENST00000369075	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
In-frame	ENST00000436547	ENST00000369075	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
In-frame	ENST00000436547	ENST00000543134	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
In-frame	ENST00000436547	ENST00000543134	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
intron-3CDS	ENST00000463089	ENST00000369075	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
intron-3CDS	ENST00000463089	ENST00000369075	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
intron-3CDS	ENST00000463089	ENST00000543134	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
intron-3CDS	ENST00000463089	ENST00000543134	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+
intron-intron	ENST00000463089	ENST00000475542	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+
intron-intron	ENST00000463089	ENST00000475542	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369093	TIAL1	chr10	121355945	-	ENST00000369075	SEC23IP	chr10	121685547	+	2525	62	143	943	266
ENST00000369093	TIAL1	chr10	121355945	-	ENST00000543134	SEC23IP	chr10	121685547	+	1113	62	143	943	266
ENST00000436547	TIAL1	chr10	121355945	-	ENST00000369075	SEC23IP	chr10	121685547	+	2540	77	158	958	266
ENST00000436547	TIAL1	chr10	121355945	-	ENST00000543134	SEC23IP	chr10	121685547	+	1128	77	158	958	266
ENST00000369093	TIAL1	chr10	121355946	-	ENST00000369075	SEC23IP	chr10	121685548	+	2525	62	143	943	266
ENST00000369093	TIAL1	chr10	121355946	-	ENST00000543134	SEC23IP	chr10	121685548	+	1113	62	143	943	266
ENST00000436547	TIAL1	chr10	121355946	-	ENST00000369075	SEC23IP	chr10	121685548	+	2540	77	158	958	266
ENST00000436547	TIAL1	chr10	121355946	-	ENST00000543134	SEC23IP	chr10	121685548	+	1128	77	158	958	266

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369093	ENST00000369075	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+	0.000774566	0.9992254
ENST00000369093	ENST00000543134	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+	0.001324348	0.99867564
ENST00000436547	ENST00000369075	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+	0.000721006	0.99927896
ENST00000436547	ENST00000543134	TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+	0.001409168	0.99859077
ENST00000369093	ENST00000369075	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+	0.000774566	0.9992254
ENST00000369093	ENST00000543134	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+	0.001324348	0.99867564
ENST00000436547	ENST00000369075	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+	0.000721006	0.99927896
ENST00000436547	ENST00000543134	TIAL1	chr10	121355946	-	SEC23IP	chr10	121685548	+	0.001409168	0.99859077

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Fusion Genomic Features for TIAL1-SEC23IP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+	4.56E-08	1
TIAL1	chr10	121355945	-	SEC23IP	chr10	121685547	+	4.56E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TIAL1-SEC23IP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:121355945/chr10:121685547)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SEC23IP

chr10:121355945

chr10:121685547

ENST00000369075

779_989

707

1443.0

Domain

DDHD

Tgene

SEC23IP

chr10:121355946

chr10:121685548

ENST00000369075

779_989

707

1443.0

Domain

DDHD

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TIAL1

chr10:121355945

chr10:121685547

ENST00000369093

205_277

393.0

Domain

RRM 3

Hgene

TIAL1

chr10:121355945

chr10:121685547

ENST00000369093

97_175

393.0

Domain

RRM 2

Hgene

TIAL1

chr10:121355945

chr10:121685547

ENST00000369093

9_85

393.0

Domain

RRM 1

Hgene

TIAL1

chr10:121355945

chr10:121685547

ENST00000436547

205_277

376.0

Domain

RRM 3

Hgene

TIAL1

chr10:121355945

chr10:121685547

ENST00000436547

97_175

376.0

Domain

RRM 2

Hgene

TIAL1

chr10:121355945

chr10:121685547

ENST00000436547

9_85

376.0

Domain

RRM 1

Hgene

TIAL1

chr10:121355946

chr10:121685548

ENST00000369093

205_277

393.0

Domain

RRM 3

Hgene

TIAL1

chr10:121355946

chr10:121685548

ENST00000369093

97_175

393.0

Domain

RRM 2

Hgene

TIAL1

chr10:121355946

chr10:121685548

ENST00000369093

9_85

393.0

Domain

RRM 1

Hgene

TIAL1

chr10:121355946

chr10:121685548

ENST00000436547

205_277

376.0

Domain

RRM 3

Hgene

TIAL1

chr10:121355946

chr10:121685548

ENST00000436547

97_175

376.0

Domain

RRM 2

Hgene

TIAL1

chr10:121355946

chr10:121685548

ENST00000436547

9_85

376.0

Domain

RRM 1

Tgene

SEC23IP

chr10:121355945

chr10:121685547

ENST00000369075

142_259

707

1443.0

Compositional bias

Note=Pro-rich

Tgene

SEC23IP

chr10:121355946

chr10:121685548

ENST00000369075

142_259

707

1443.0

Compositional bias

Note=Pro-rich

Tgene

SEC23IP

chr10:121355945

chr10:121685547

ENST00000369075

644_707

707

1443.0

Domain

Note=SAM

Tgene

SEC23IP

chr10:121355946

chr10:121685548

ENST00000369075

644_707

707

1443.0

Domain

Note=SAM

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Fusion Gene Sequence for TIAL1-SEC23IP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>90836_90836_1_TIAL1-SEC23IP_TIAL1_chr10_121355945_ENST00000369093_SEC23IP_chr10_121685547_ENST00000369075_length(transcript)=2525nt_BP=62nt
TTGTCCCGGGATCGCTCCGTCGCACCCACCATGATGGAAGACGACGGGCAGCCCCGGACTCTAAAAAAGCAGCGTCAGAAAAGAAGGCAG
TGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGA
GGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACA
ACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAGTTGATAGGATAGATG
AGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAGAACCTATGATTGTTC
CAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGAGTCTCTCTCGTATGG
GATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTCATACGTCTTCAACCC
AGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTC
CAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTCTCCAAGAAAAACCAA
TAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGTTACTACTTAAAGAAA
TTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTCTGCACAGAAAGTCCC
AGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTGATTCATTAACAATTG
CTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAACTAACACAGTGAAAAAAATCAGTACCACATTTGGACAGTATA
GGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGATCAGTTTAGTTGTATAGTTGTCAAAGTTATATGTGATATCAA
TGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTTAGTGGGCTATTAAACTTGGATTTTTCTTTTTATT
AATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTATAGTAATATGATTTTTAAGAGATTTATGTTCTACTTAAAATGT
GAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAATAATCAAGATCACTCATATCCCAACTGAATCTGA
GGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGATGCACCTTATTTTCAAGAAGTCCTGGGAAGCGCT
CTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTTTGTCATCCAAGGTAGCTGTGCACTTGCCTTGTTG
CTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGTTTTCTATTAATTTCACTTATACCAAAGTGTTTGA
AAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACAAGACTGCTTTGTAATATTTCACTTTGTTTTACTACAAATTCA
GATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAATACTATGTGGGAATGCTGATTTTCTTTTGTTACGTAGTGGAA
ACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATATATGATACACATTTTTTGTGTATGTATTCTAATT
AGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTTATGTATTTCTCTTGTCTTCCTTAAAAGTGTCCCCATGAACTC
AGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTTAGCATTGGCTCCTAATGGTAGAATTAGAACAGCA
AGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACCTCATTCTACAGCTGAGGCCAGGACAATAAATGCCTTTCCCAG
ACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCTTCATTTCTCTCTCTCAGGACTACTACTTTTTAAT
TACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGGGTTATTTATATACATTTCAATAAAATCCAATTTGATTTTTCA

>90836_90836_1_TIAL1-SEC23IP_TIAL1_chr10_121355945_ENST00000369093_SEC23IP_chr10_121685547_ENST00000369075_length(amino acids)=266AA_BP=
MASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPL
DPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEE

--------------------------------------------------------------
>90836_90836_2_TIAL1-SEC23IP_TIAL1_chr10_121355945_ENST00000369093_SEC23IP_chr10_121685547_ENST00000543134_length(transcript)=1113nt_BP=62nt
TTGTCCCGGGATCGCTCCGTCGCACCCACCATGATGGAAGACGACGGGCAGCCCCGGACTCTAAAAAAGCAGCGTCAGAAAAGAAGGCAG
TGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGA
GGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACA
ACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAGTTGATAGGATAGATG
AGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAGAACCTATGATTGTTC
CAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGAGTCTCTCTCGTATGG
GATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTCATACGTCTTCAACCC
AGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTC
CAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTCTCCAAGAAAAACCAA
TAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGTTACTACTTAAAGAAA
TTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTCTGCACAGAAAGTCCC
AGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTGATTCATTAACAATTG

>90836_90836_2_TIAL1-SEC23IP_TIAL1_chr10_121355945_ENST00000369093_SEC23IP_chr10_121685547_ENST00000543134_length(amino acids)=266AA_BP=
MASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPL
DPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEE

--------------------------------------------------------------
>90836_90836_3_TIAL1-SEC23IP_TIAL1_chr10_121355945_ENST00000436547_SEC23IP_chr10_121685547_ENST00000369075_length(transcript)=2540nt_BP=77nt
ACCCTGCCCTCCCCCTTGTCCCGGGATCGCTCCGTCGCACCCACCATGATGGAAGACGACGGGCAGCCCCGGACTCTAAAAAAGCAGCGT
CAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAAT
CCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGG
TTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAG
TTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAG
AACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGA
GTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTC
ATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAA
AGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTC
TCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGT
TACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTC
TGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTG
ATTCATTAACAATTGCTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAACTAACACAGTGAAAAAAATCAGTACCA
CATTTGGACAGTATAGGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGATCAGTTTAGTTGTATAGTTGTCAAAGT
TATATGTGATATCAATGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTTAGTGGGCTATTAAACTTGG
ATTTTTCTTTTTATTAATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTATAGTAATATGATTTTTAAGAGATTTATG
TTCTACTTAAAATGTGAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAATAATCAAGATCACTCATAT
CCCAACTGAATCTGAGGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGATGCACCTTATTTTCAAGAA
GTCCTGGGAAGCGCTCTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTTTGTCATCCAAGGTAGCTGT
GCACTTGCCTTGTTGCTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGTTTTCTATTAATTTCACTTA
TACCAAAGTGTTTGAAAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACAAGACTGCTTTGTAATATTTCACTTTGT
TTTACTACAAATTCAGATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAATACTATGTGGGAATGCTGATTTTCTTT
TGTTACGTAGTGGAAACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATATATGATACACATTTTTTGT
GTATGTATTCTAATTAGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTTATGTATTTCTCTTGTCTTCCTTAAAAG
TGTCCCCATGAACTCAGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTTAGCATTGGCTCCTAATGGT
AGAATTAGAACAGCAAGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACCTCATTCTACAGCTGAGGCCAGGACAAT
AAATGCCTTTCCCAGACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCTTCATTTCTCTCTCTCAGGA
CTACTACTTTTTAATTACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGGGTTATTTATATACATTTCAATAAAATC

>90836_90836_3_TIAL1-SEC23IP_TIAL1_chr10_121355945_ENST00000436547_SEC23IP_chr10_121685547_ENST00000369075_length(amino acids)=266AA_BP=
MASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPL
DPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEE

--------------------------------------------------------------
>90836_90836_4_TIAL1-SEC23IP_TIAL1_chr10_121355945_ENST00000436547_SEC23IP_chr10_121685547_ENST00000543134_length(transcript)=1128nt_BP=77nt
ACCCTGCCCTCCCCCTTGTCCCGGGATCGCTCCGTCGCACCCACCATGATGGAAGACGACGGGCAGCCCCGGACTCTAAAAAAGCAGCGT
CAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAAT
CCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGG
TTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAG
TTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAG
AACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGA
GTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTC
ATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAA
AGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTC
TCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGT
TACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTC
TGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTG

>90836_90836_4_TIAL1-SEC23IP_TIAL1_chr10_121355945_ENST00000436547_SEC23IP_chr10_121685547_ENST00000543134_length(amino acids)=266AA_BP=
MASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPL
DPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEE

--------------------------------------------------------------
>90836_90836_5_TIAL1-SEC23IP_TIAL1_chr10_121355946_ENST00000369093_SEC23IP_chr10_121685548_ENST00000369075_length(transcript)=2525nt_BP=62nt
TTGTCCCGGGATCGCTCCGTCGCACCCACCATGATGGAAGACGACGGGCAGCCCCGGACTCTAAAAAAGCAGCGTCAGAAAAGAAGGCAG
TGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGA
GGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACA
ACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAGTTGATAGGATAGATG
AGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAGAACCTATGATTGTTC
CAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGAGTCTCTCTCGTATGG
GATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTCATACGTCTTCAACCC
AGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTC
CAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTCTCCAAGAAAAACCAA
TAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGTTACTACTTAAAGAAA
TTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTCTGCACAGAAAGTCCC
AGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTGATTCATTAACAATTG
CTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAACTAACACAGTGAAAAAAATCAGTACCACATTTGGACAGTATA
GGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGATCAGTTTAGTTGTATAGTTGTCAAAGTTATATGTGATATCAA
TGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTTAGTGGGCTATTAAACTTGGATTTTTCTTTTTATT
AATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTATAGTAATATGATTTTTAAGAGATTTATGTTCTACTTAAAATGT
GAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAATAATCAAGATCACTCATATCCCAACTGAATCTGA
GGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGATGCACCTTATTTTCAAGAAGTCCTGGGAAGCGCT
CTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTTTGTCATCCAAGGTAGCTGTGCACTTGCCTTGTTG
CTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGTTTTCTATTAATTTCACTTATACCAAAGTGTTTGA
AAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACAAGACTGCTTTGTAATATTTCACTTTGTTTTACTACAAATTCA
GATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAATACTATGTGGGAATGCTGATTTTCTTTTGTTACGTAGTGGAA
ACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATATATGATACACATTTTTTGTGTATGTATTCTAATT
AGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTTATGTATTTCTCTTGTCTTCCTTAAAAGTGTCCCCATGAACTC
AGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTTAGCATTGGCTCCTAATGGTAGAATTAGAACAGCA
AGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACCTCATTCTACAGCTGAGGCCAGGACAATAAATGCCTTTCCCAG
ACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCTTCATTTCTCTCTCTCAGGACTACTACTTTTTAAT
TACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGGGTTATTTATATACATTTCAATAAAATCCAATTTGATTTTTCA

>90836_90836_5_TIAL1-SEC23IP_TIAL1_chr10_121355946_ENST00000369093_SEC23IP_chr10_121685548_ENST00000369075_length(amino acids)=266AA_BP=
MASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPL
DPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEE

--------------------------------------------------------------
>90836_90836_6_TIAL1-SEC23IP_TIAL1_chr10_121355946_ENST00000369093_SEC23IP_chr10_121685548_ENST00000543134_length(transcript)=1113nt_BP=62nt
TTGTCCCGGGATCGCTCCGTCGCACCCACCATGATGGAAGACGACGGGCAGCCCCGGACTCTAAAAAAGCAGCGTCAGAAAAGAAGGCAG
TGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGA
GGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACA
ACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAGTTGATAGGATAGATG
AGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAGAACCTATGATTGTTC
CAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGAGTCTCTCTCGTATGG
GATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTCATACGTCTTCAACCC
AGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTC
CAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTCTCCAAGAAAAACCAA
TAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGTTACTACTTAAAGAAA
TTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTCTGCACAGAAAGTCCC
AGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTGATTCATTAACAATTG

>90836_90836_6_TIAL1-SEC23IP_TIAL1_chr10_121355946_ENST00000369093_SEC23IP_chr10_121685548_ENST00000543134_length(amino acids)=266AA_BP=
MASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPL
DPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEE

--------------------------------------------------------------
>90836_90836_7_TIAL1-SEC23IP_TIAL1_chr10_121355946_ENST00000436547_SEC23IP_chr10_121685548_ENST00000369075_length(transcript)=2540nt_BP=77nt
ACCCTGCCCTCCCCCTTGTCCCGGGATCGCTCCGTCGCACCCACCATGATGGAAGACGACGGGCAGCCCCGGACTCTAAAAAAGCAGCGT
CAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAAT
CCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGG
TTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAG
TTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAG
AACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGA
GTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTC
ATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAA
AGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTC
TCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGT
TACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTC
TGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTG
ATTCATTAACAATTGCTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAACTAACACAGTGAAAAAAATCAGTACCA
CATTTGGACAGTATAGGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGATCAGTTTAGTTGTATAGTTGTCAAAGT
TATATGTGATATCAATGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTTAGTGGGCTATTAAACTTGG
ATTTTTCTTTTTATTAATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTATAGTAATATGATTTTTAAGAGATTTATG
TTCTACTTAAAATGTGAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAATAATCAAGATCACTCATAT
CCCAACTGAATCTGAGGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGATGCACCTTATTTTCAAGAA
GTCCTGGGAAGCGCTCTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTTTGTCATCCAAGGTAGCTGT
GCACTTGCCTTGTTGCTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGTTTTCTATTAATTTCACTTA
TACCAAAGTGTTTGAAAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACAAGACTGCTTTGTAATATTTCACTTTGT
TTTACTACAAATTCAGATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAATACTATGTGGGAATGCTGATTTTCTTT
TGTTACGTAGTGGAAACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATATATGATACACATTTTTTGT
GTATGTATTCTAATTAGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTTATGTATTTCTCTTGTCTTCCTTAAAAG
TGTCCCCATGAACTCAGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTTAGCATTGGCTCCTAATGGT
AGAATTAGAACAGCAAGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACCTCATTCTACAGCTGAGGCCAGGACAAT
AAATGCCTTTCCCAGACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCTTCATTTCTCTCTCTCAGGA
CTACTACTTTTTAATTACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGGGTTATTTATATACATTTCAATAAAATC

>90836_90836_7_TIAL1-SEC23IP_TIAL1_chr10_121355946_ENST00000436547_SEC23IP_chr10_121685548_ENST00000369075_length(amino acids)=266AA_BP=
MASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPL
DPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEE

--------------------------------------------------------------
>90836_90836_8_TIAL1-SEC23IP_TIAL1_chr10_121355946_ENST00000436547_SEC23IP_chr10_121685548_ENST00000543134_length(transcript)=1128nt_BP=77nt
ACCCTGCCCTCCCCCTTGTCCCGGGATCGCTCCGTCGCACCCACCATGATGGAAGACGACGGGCAGCCCCGGACTCTAAAAAAGCAGCGT
CAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCTTCCCTCCCCTCAGAAT
CCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAAGTTGGCGCCGGACAGG
TTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTTCTCACTATTCGAGGAG
TTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCAGTGGCATATAGATTAG
AACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCATTTAGAATTGAAAGAGA
GTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAATGAGTTTGCCCGTGCTC
ATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAAGTAGTTGAAGCAGAAA
AGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGCCGAATTGACTACGTTC
TCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCTGAAGATACTGCTCTGT
TACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTTACTGTACTTTCTTGTC
TGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGATGGATGACAGAAGAGTG

>90836_90836_8_TIAL1-SEC23IP_TIAL1_chr10_121355946_ENST00000436547_SEC23IP_chr10_121685548_ENST00000543134_length(amino acids)=266AA_BP=
MASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPL
DPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TIAL1-SEC23IP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SEC23IP	chr10:121355945	chr10:121685547	ENST00000369075		11	19	1_367	707.0	1443.0	SEC23A
Tgene	SEC23IP	chr10:121355946	chr10:121685548	ENST00000369075		11	19	1_367	707.0	1443.0	SEC23A

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TIAL1-SEC23IP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TIAL1-SEC23IP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source