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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TIMM44-NFIX (FusionGDB2 ID:90951)

Fusion Gene Summary for TIMM44-NFIX

check button Fusion gene summary
Fusion gene informationFusion gene name: TIMM44-NFIX
Fusion gene ID: 90951
HgeneTgene
Gene symbol

TIMM44

NFIX

Gene ID

10469

4784

Gene nametranslocase of inner mitochondrial membrane 44nuclear factor I X
SynonymsTIM44CTF|MRSHSS|NF-I/X|NF1-X|NF1A|SOTOS2
Cytomap

19p13.2

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial import inner membrane translocase subunit TIM44translocase of inner mitochondrial membrane 44 homolognuclear factor 1 X-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/X
Modification date2020031320200329
UniProtAcc.

Q14938

Ensembl transtripts involved in fusion geneENST00000270538, ENST00000598968, 
ENST00000358552, ENST00000587260, 
ENST00000588228, ENST00000588680, 
ENST00000360105, ENST00000397661, 
ENST00000585575, ENST00000587760, 
ENST00000592199, 
Fusion gene scores* DoF score5 X 4 X 4=8022 X 13 X 10=2860
# samples 426
** MAII scorelog2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/2860*10)=-3.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TIMM44 [Title/Abstract] AND NFIX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTIMM44(8008492)-NFIX(13135835), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNFIX

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

TgeneNFIX

GO:0045944

positive regulation of transcription by RNA polymerase II

19706729


check buttonFusion gene breakpoints across TIMM44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NFIX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-2054-01ATIMM44chr19

8008492

-NFIXchr19

13135835

+


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Fusion Gene ORF analysis for TIMM44-NFIX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000270538ENST00000358552TIMM44chr19

8008492

-NFIXchr19

13135835

+
5CDS-5UTRENST00000270538ENST00000587260TIMM44chr19

8008492

-NFIXchr19

13135835

+
5CDS-5UTRENST00000270538ENST00000588228TIMM44chr19

8008492

-NFIXchr19

13135835

+
5CDS-intronENST00000270538ENST00000588680TIMM44chr19

8008492

-NFIXchr19

13135835

+
In-frameENST00000270538ENST00000360105TIMM44chr19

8008492

-NFIXchr19

13135835

+
In-frameENST00000270538ENST00000397661TIMM44chr19

8008492

-NFIXchr19

13135835

+
In-frameENST00000270538ENST00000585575TIMM44chr19

8008492

-NFIXchr19

13135835

+
In-frameENST00000270538ENST00000587760TIMM44chr19

8008492

-NFIXchr19

13135835

+
In-frameENST00000270538ENST00000592199TIMM44chr19

8008492

-NFIXchr19

13135835

+
intron-3CDSENST00000598968ENST00000360105TIMM44chr19

8008492

-NFIXchr19

13135835

+
intron-3CDSENST00000598968ENST00000397661TIMM44chr19

8008492

-NFIXchr19

13135835

+
intron-3CDSENST00000598968ENST00000585575TIMM44chr19

8008492

-NFIXchr19

13135835

+
intron-3CDSENST00000598968ENST00000587760TIMM44chr19

8008492

-NFIXchr19

13135835

+
intron-3CDSENST00000598968ENST00000592199TIMM44chr19

8008492

-NFIXchr19

13135835

+
intron-5UTRENST00000598968ENST00000358552TIMM44chr19

8008492

-NFIXchr19

13135835

+
intron-5UTRENST00000598968ENST00000587260TIMM44chr19

8008492

-NFIXchr19

13135835

+
intron-5UTRENST00000598968ENST00000588228TIMM44chr19

8008492

-NFIXchr19

13135835

+
intron-intronENST00000598968ENST00000588680TIMM44chr19

8008492

-NFIXchr19

13135835

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000270538TIMM44chr198008492-ENST00000397661NFIXchr1913135835+32003142691612447
ENST00000270538TIMM44chr198008492-ENST00000592199NFIXchr1913135835+17963142691795509
ENST00000270538TIMM44chr198008492-ENST00000587760NFIXchr1913135835+17573142691612447
ENST00000270538TIMM44chr198008492-ENST00000585575NFIXchr1913135835+17963142691795509
ENST00000270538TIMM44chr198008492-ENST00000360105NFIXchr1913135835+56723142691489406

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000270538ENST00000397661TIMM44chr198008492-NFIXchr1913135835+0.0518122430.9481878
ENST00000270538ENST00000592199TIMM44chr198008492-NFIXchr1913135835+0.0535108930.9464891
ENST00000270538ENST00000587760TIMM44chr198008492-NFIXchr1913135835+0.07187620.9281238
ENST00000270538ENST00000585575TIMM44chr198008492-NFIXchr1913135835+0.0535108930.9464891
ENST00000270538ENST00000360105TIMM44chr198008492-NFIXchr1913135835+0.0170016720.9829983

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Fusion Genomic Features for TIMM44-NFIX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TIMM44chr198008491-NFIXchr1913135834+1.50E-111
TIMM44chr198008491-NFIXchr1913135834+1.50E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TIMM44-NFIX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:8008492/chr19:13135835)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NFIX

Q14938

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNFIXchr19:8008492chr19:13135835ENST000005855750111_1941495.0DNA bindingCTF/NF-I
TgeneNFIXchr19:8008492chr19:13135835ENST00000587260091_1940281.6666666666667DNA bindingCTF/NF-I
TgeneNFIXchr19:8008492chr19:13135835ENST000005877600101_1941460.6666666666667DNA bindingCTF/NF-I
TgeneNFIXchr19:8008492chr19:13135835ENST00000397661010398_4069878.6666666666666Motif9aaTAD
TgeneNFIXchr19:8008492chr19:13135835ENST00000585575011398_4061495.0Motif9aaTAD
TgeneNFIXchr19:8008492chr19:13135835ENST0000058726009398_4060281.6666666666667Motif9aaTAD
TgeneNFIXchr19:8008492chr19:13135835ENST00000587760010398_4061460.6666666666667Motif9aaTAD
TgeneNFIXchr19:8008492chr19:13135835ENST00000592199011398_4069503.0Motif9aaTAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTIMM44chr19:8008492chr19:13135835ENST00000270538-113166_17315453.0Nucleotide bindingATP
TgeneNFIXchr19:8008492chr19:13135835ENST000003976610101_1949878.6666666666666DNA bindingCTF/NF-I
TgeneNFIXchr19:8008492chr19:13135835ENST000005921990111_1949503.0DNA bindingCTF/NF-I


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Fusion Gene Sequence for TIMM44-NFIX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>90951_90951_1_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000360105_length(transcript)=5672nt_BP=314nt
ACAGATCTGACCCTCCCAGGAGTGCCCTCCCCCGGGCCACATCCAGTCACGGGCCCCGTCCTTCCAAAACACTGCCCTATCAGAGGTCAA
GCTCTCTAGGCATTCCCTACCCTTTTAATGCCCCGCCCTATGACGGACCCAATCGGAGGGCTCTCCCTACCCGAAACCCCGCTCCTGGAG
CGGCTTTTCTCAGGCTTGCGCGGCTCTAGGCCGAAGCGGCGGATGACGCAACCGGGCCGCGCCGCGAGAAGGTCACACGATTCTCCAACA
TGGCGGCGGCGGCCCTGCGGAGTGGCTGGTGCCGCTGTCCACGGGATGAGTTCCACCCGTTCATCGAGGCACTGCTGCCTCACGTCCGCG
CTTTCTCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCATGAAAAGCGGATGTCGAAGGACGAGGAGCGGG
CGGTGAAGGACGAGCTGCTGGGCGAGAAGCCCGAGATCAAGCAGAAGTGGGCATCCCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGC
CCGAGTTCCGCGAGGACTTCGTGCTGACCATCACGGGCAAGAAGCCCCCCTGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATCC
GGCGGATTGACTGCCTGCGCCAGGCTGACAAGGTGTGGCGGCTGGACCTGGTCATGGTGATTTTGTTTAAGGGGATCCCCCTGGAAAGTA
CTGATGGGGAGCGGCTCTACAAGTCGCCTCAGTGCTCGAACCCCGGCCTGTGCGTCCAGCCACATCACATTGGAGTCACAATCAAAGAAC
TGGATCTTTATCTGGCTTACTTTGTCCACACTCCGGAATCCGGACAATCAGATAGTTCAAACCAGCAAGGAGATGCGGACATCAAACCAC
TGCCCAACGGGCACTTAAGTTTCCAGGACTGTTTTGTGACTTCCGGGGTCTGGAATGTGACGGAGCTGGTGAGAGTATCACAGACTCCTG
TTGCAACAGCATCAGGGCCCAACTTCTCCCTGGCGGACCTGGAGAGTCCCAGCTACTACAACATCAACCAGGTGACCCTGGGGCGGCGGT
CCATCACCTCCCCTCCTTCCACCAGCACCACCAAGCGCCCCAAGTCCATCGATGACAGTGAGATGGAGAGCCCTGTTGATGACGTGTTCT
ATCCCGGGACAGGCCGTTCCCCAGCAGCTGGCAGCAGCCAGTCCAGCGGGTGGCCCAACGATGTGGATGCAGGGAGCCCCCGGGCCACAG
CATCAGCCCTGCACTTCCCCTCCACGTCCATCATCCAGCAGTCGAGCCCGTATTTCACGCACCCGACCATCCGCTACCACCACCACCACG
GGCAGGACTCACTGAAGGAGTTTGTGCAGTTTGTGTGCTCGGATGGCTCGGGCCAGGCCACCGGACAGCATTCGCAACGACAGGCGCCTC
CTCTGCCAACCGGTTTGTCAGCATCGGACCCCGGGACGGCAACTTTCTGAACATCCCACAGCAGTCTCAGTCCTGGTTCCTCTGATAAGA
TCGACAAAAGAAACAACAAAATGAGAAGAAGAGGTTCCTCGAAAGGGGGGAGAAGAAATTTTGAGAATGGAAAAATCCCCCAGCCCAGCC
CAGCCCCACCGAAAAGCAAAAATTACACGTCGTCAGCCACTCAGCCCTTCTCTCCTCCAGCCCGGGGACCCCCGCGGGCCCCAGAAGCAG
CCCAGTTCTCAGAGAGCCCTTGGAAGGGGTCTCGGTGGAGCTGTGCACCAGCAGCCAAGCAGAAAGAAACACGCGACATGGACTCTGTCA
AGTAGAGGACAGAAAGCAAGAAAGGATGCAGAACTGCCTTCCTCCCCCTGACCCCGCCCCGGCCTTCTGGGGAAGGAACAAAGTCCCCAA
ACAAAGCAACCAGCACAATTCTGAAGGGGCCTGGCCTCCACCCTCACCCCTTCCTAGGGGAACCCCACCCTCCACACAGCCGGAGCTGCC
CTAGGGAGCCTGGAGGGCCAGCTTGTAAAGATGATGGGGTTTAGATCCCTCAGGCTCTCCCCTCCAGACTCCGCCCTTCCCTCCCTCCCT
CCCTCCCTCCCTCTCTGCCAAGGCTCCAGCTTCTTCCCCCAGCTGCTCCCGACCAGGAGGGGGAGAGCAGCCTCCACTTACCCCACCCCA
CCCTTGGGCTAAAAGCCCCCAGGCGGGCAGGGGGTGACCCCTGGAGCTAGTTGCGTGTCCCAGAATGGAGGGTGTTCTGACACCCCACCC
TGAGCCGCAAGAGCAGTCCTGGGGCCCTGGACCCCTCTGTACAGTCCGTAGGAAAAAGTCGGAATGCTCTCGACGGCCTCGTCCCAGCCT
GGGACAGGCCCCCTTTCCCCTCTCTCTGCAGGCCAGGAGGGCCTCCTTCCTGCCACGAGGGAGGGGAGTCGGGCCCCAGGTCGCCCCCGC
CCCCAGCCCTGCATGCAGGTGCCCTCGCTCCGCCCCATCAGTTCCTGCCCCTGCCCCTCATGCAGACTGCCCTGCTGGGGCCGGGCCGGA
GGGTGGAGCAGAAAGGGGACCCCGGAGCCGAGCGAGGAGGACCAGGCAGCCGCCGCTGCCGCGCTAAGCCACCACCTGCGCTTAGGTAGG
CGTCCTGCTCGCCGACTTTCAGTTCCTTGGGAGGGTGTTGGGTGTCGTCCTTTTCAAAAGTGTTTTGGAGCTTTCTGTGCCCCCCGACTT
TCCCCCGCCTCCCCGCCCCCCACGTGGCCACTTTTCTCTGGATTTTAGCTGTAATGTCTTTACTCTTTATTTAGGGGTGGGGCATTCATT
GTTTGGGTCTTTTGCTGTTGGAATGGGAACTCCTCCTCCATTTGAGCAACTTGGGAACAATTTGGTAACACACCACAGGAAGTAGCTCTC
CCCCCCAGCCCCCTCCTCCCTCAAGGGAGGGTTGGGGGGCCTGTCCAGAGGGTCTTCAGAAGCCCCCCTGGGAGGGAGGGGAGGATGAGC
ACGCCCAGCTCCCCTCCAGGGTGTGACTTGGCCCCTCTGGCTTGTCTTTCTGTGCCTTACTCCTCCTCCTGCGTCTCCCGTTCCTGGCCC
CTTCTTGAGTCCTTGTGCCTCTCTCTTTCTCTCTCTTTCTTAATTGTATGAAAACACAAAGCACAGGTCAGGATCCTCTGAGAGAAAATC
AACATTGCACCACGTAGGGGTGGGCTATGGGCTGTATTTATTGTGAATCTAGTTTGTGAGGCTGTGGCCCCGAGCTGGCGGAGGGAGGGA
AGAGGAGGGAGTGACGGGAGGGGAGGAGGTCAGCGACCTGGGGCCGTAGCGGCAGGCGAACGGTGCCTGCTACCCAGCTGGAAGCCACAA
GGTGGCTGGCTCCAGGGGCGGCTTTTGTTGGAAGTTGAGTGAAGCCCTCCCCCTGTCCTCAGCGTGCAGCCCTAGAGGACCCCAGGGCTG
AGGGGCAGTGGATCCTGCGGGAGTCTCCCGGGGCGTGGGGAGTAAGGCCCCGGGGGTGGGGGGCCGGGTGGGCCGGGCGTGACGCGCGGT
CAAAGTGCAATGATTTTTCAGTTCGGTTGGCTAAACAGGGTCAGAGCTGAGAGCGAAGCAGAAGGGGCTCCCTGTCCGGCCCACGTGCCC
TTTCCCTCGACGACAGTCGAGGGCTCGGGCTCTGTGGGACTGTGGGAGCTAGGGTCTGCGGGGCGCCTGCCCGGGCGAGGTCGGAAGCTG
CAGGCCAGCTGGGCCCGGGCCGGAGCGTGCCCGGCGGGGCTGCCCGGGCGGGCAGGGGGTGGGGGCTGCTCCTTTCCCAAGTGGTGTTGT
GAGGGGCAATGAGGGCAACAGGAGATGTGGGGACGTGTTAGGAGAGAAAAAAAAAAAAACAAAAATATATATGGGGGAAATTAACTTTTT
TTTTTCATTGAACCAAGTGCAATGCATCAGAGAGTTTTCCTATCTTTGTATGTTAAGAGATTAAGAAAAAAAAATTCTATTTTTGTTGTA
ATGTCCTCGCGGCTCTGGGGACGCTAAAAGAACCGGGCCTGCCCCGCCCTGCGCGGGGATAACGAAAGCTGAGTGTTTTTCCCTTTTTTT
TGTTCGTTTTTAGTTTTTTTTTTTTTAAGTCGTTTTCCTGCGTTGACGAGGATGATCTGGGGTTTTTATTTGTTTCGTCGTTCGTTCTGT
TTCGGTGGGAGGGCTGAAGGAAACGTTCACATTTTAGAGTTTAAAAAAAACACCTCGACATTTAAAAAATCAACCAACACAAGATCAAAA
AGGAAAAGGACGAGAGAAAAATTATTTTTAAGATAATTAAACATAAAACCCTGGTGCTTCTTACATTATAAAGTACGTTTTAAAGAACCC
ACAAACTATTATACATAAGTTTATGAATCAATTAAATATCCTGCACTTGTTAGGAATACGCATATCCCTTCTTTGTTGAGTTTAACGGAA
CGGGACAGCGGCGTGCCCCCGGCGGCTGGACTGCTCCGGCCGCGGGTCTCCCCGGGCGCCCCTCCCTGGGGCCCAGCACCCCTCCTCGCC
CCATCCCCGTCCGGGTACGGGGGCGCGGCAGGGGTCCCCGGCCCCTCCCCCGCAGAGGTCAATGCCAACGAACAAACGTCCCCTCCCTCC
CTCCCTCTCCGCCCCGAGCGCCCTTCTTTGAGCCAGACGCCAACTTGACCCTCACCAGCATTATCAGGAGCGCGCTCAGCAAGTTGGTAG
TTTCCTCCCCCCTTTCCCGGCGCCCCTCCCGCCCCCATTCAACATCTCTCATCCTATCCCCGACCCCCTCCGGGGAACACCGGGAAGGCT
CGACGCTCCAGGACAGGACCAGCCACGCAGACAGGTCGATTTGCCCAGGCCCGCGCCCGCACGCACGCACGCACACGGCCCCGCACACAG
CCCCGCCCCACCCCGCAACCAGCCCTGTCGACTGCCTTATACACCCGCCCCCGCGCTGGCCGGCCGACCTAGTGCCTTGTTCTCACCCCC
GTGCTGGCGGAGCGGACGCCGCGCTCTGGGTCCCAGAGGGGCCGGGTGGCTCAGACGACCCACCACTCCCCCACCCTGACCGTGCTGAAC
AGACCCCCCCACACGAGAGAAAATAAAGGAGCAATAAAGTCACGAGAACTTTCGTCCCCCAATCGAGAGCCCGAGGGGCACCCCAGCCCC
GCCTCTGCTCCCCCCCACCCCACCCACCCTCGGGGCGCCCCCCTCCCCCCGCAAGCCAGCCTGGGCCAGCCCCGCTTCGGCCCCTCCCGG
GAGATCCGTGCGCCCGACCAGCACCAGCATCGCGGACCGCAAAGGCCGCCCGTCCCGTCAAACAAGTTTCTTCTTAGGCTAAGAAACGCA
GTATATACGAGTATCTCTATATATAGTACTAATGGATTTGGTGTGCTTCCCCCTTAGCGTCCCCCTCCCTCTGCTCCTCCTCCTTCAGCC
TGGTCTCCCCCTCTTCTCTGCCCTCCACCCCCGTCTCTGCACTGAGATACATAAGAAACAAGGGTAGTTTACTGTCTGTTTTGTTTTCTG
GGTTTTCAGTGTCCTAGCGGAATGCAAGTAGGCAGCCAGCCCGTCTGTTCCCTCTCCGCCCCGCCCCGCCCCGCCCCCGTCACTGCGCTT
CTGTTATACCATCTTTGCCTGACTCTCTCCGGCTTCTCCATTGAATGGCTAATGTGTATGTGAAATAAAGAAATAAAGAAAAACAAACGC

>90951_90951_1_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000360105_length(amino acids)=406AA_BP=15
MAAAALRSGWCRCPRDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIR
PEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKE
LDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRR
SITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHH

--------------------------------------------------------------
>90951_90951_2_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000397661_length(transcript)=3200nt_BP=314nt
ACAGATCTGACCCTCCCAGGAGTGCCCTCCCCCGGGCCACATCCAGTCACGGGCCCCGTCCTTCCAAAACACTGCCCTATCAGAGGTCAA
GCTCTCTAGGCATTCCCTACCCTTTTAATGCCCCGCCCTATGACGGACCCAATCGGAGGGCTCTCCCTACCCGAAACCCCGCTCCTGGAG
CGGCTTTTCTCAGGCTTGCGCGGCTCTAGGCCGAAGCGGCGGATGACGCAACCGGGCCGCGCCGCGAGAAGGTCACACGATTCTCCAACA
TGGCGGCGGCGGCCCTGCGGAGTGGCTGGTGCCGCTGTCCACGGGATGAGTTCCACCCGTTCATCGAGGCACTGCTGCCTCACGTCCGCG
CTTTCTCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCATGAAAAGCGGATGTCGAAGGACGAGGAGCGGG
CGGTGAAGGACGAGCTGCTGGGCGAGAAGCCCGAGATCAAGCAGAAGTGGGCATCCCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGC
CCGAGTTCCGCGAGGACTTCGTGCTGACCATCACGGGCAAGAAGCCCCCCTGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATCC
GGCGGATTGACTGCCTGCGCCAGGCTGACAAGGTGTGGCGGCTGGACCTGGTCATGGTGATTTTGTTTAAGGGGATCCCCCTGGAAAGTA
CTGATGGGGAGCGGCTCTACAAGTCGCCTCAGTGCTCGAACCCCGGCCTGTGCGTCCAGCCACATCACATTGGAGTCACAATCAAAGAAC
TGGATCTTTATCTGGCTTACTTTGTCCACACTCCGGAATCCGGACAATCAGATAGTTCAAACCAGCAAGGAGATGCGGACATCAAACCAC
TGCCCAACGGGCACTTAAGTTTCCAGGACTGTTTTGTGACTTCCGGGGTCTGGAATGTGACGGAGCTGGTGAGAGTATCACAGACTCCTG
TTGCAACAGCATCAGGGCCCAACTTCTCCCTGGCGGACCTGGAGAGTCCCAGCTACTACAACATCAACCAGGTGACCCTGGGGCGGCGGT
CCATCACCTCCCCTCCTTCCACCAGCACCACCAAGCGCCCCAAGTCCATCGATGACAGTGAGATGGAGAGCCCTGTTGATGACGTGTTCT
ATCCCGGGACAGGCCGTTCCCCAGCAGCTGGCAGCAGCCAGTCCAGCGGGTGGCCCAACGATGTGGATGCAGGCCCGGCTTCTCTAAAGA
AGTCAGGAAAGCTGGACTTCTGCAGTGCCCTCTCCTCTCAGGGCAGCTCCCCGCGCATGGCTTTCACCCACCACCCGCTGCCTGTGCTTG
CTGGAGTCAGACCAGGGAGCCCCCGGGCCACAGCATCAGCCCTGCACTTCCCCTCCACGTCCATCATCCAGCAGTCGAGCCCGTATTTCA
CGCACCCGACCATCCGCTACCACCACCACCACGGGCAGGACTCACTGAAGGAGTTTGTGCAGTTTGTGTGCTCGGATGGCTCGGGCCAGG
CCACCGGACAGCATTCGCAACGACAGGCGCCTCCTCTGCCAACCGGTTTGTCAGCATCGGACCCCGGGACGGCAACTTTCTGAACATCCC
ACAGCAGTCTCAGTCCTGGTTCCTCTGATAAGATCGACAAAAGAAACAACAAAATGAGAAGAAGAGGTTCCTCGAAAGGGGGGAGAAGAA
ATTTTGAGAATGGAAAAATCCCCCAGCCCAGCCCAGCCCCACCGAAAAGCAAAAATTACACGTCGTCAGCCACTCAGCCCTTCTCTCCTC
CAGCCCGGGGACCCCCGCGGGCCCCAGAAGCAGCCCAGTTCTCAGAGAGCCCTTGGAAGGGGTCTCGGTGGAGCTGTGCACCAGCAGCCA
AGCAGAAAGAAACACGCGACATGGACTCTGTCAAGTAGAGGACAGAAAGCAAGAAAGGATGCAGAACTGCCTTCCTCCCCCTGACCCCGC
CCCGGCCTTCTGGGGAAGGAACAAAGTCCCCAAACAAAGCAACCAGCACAATTCTGAAGGGGCCTGGCCTCCACCCTCACCCCTTCCTAG
GGGAACCCCACCCTCCACACAGCCGGAGCTGCCCTAGGGAGCCTGGAGGGCCAGCTTGTAAAGATGATGGGGTTTAGATCCCTCAGGCTC
TCCCCTCCAGACTCCGCCCTTCCCTCCCTCCCTCCCTCCCTCCCTCTCTGCCAAGGCTCCAGCTTCTTCCCCCAGCTGCTCCCGACCAGG
AGGGGGAGAGCAGCCTCCACTTACCCCACCCCACCCTTGGGCTAAAAGCCCCCAGGCGGGCAGGGGGTGACCCCTGGAGCTAGTTGCGTG
TCCCAGAATGGAGGGTGTTCTGACACCCCACCCTGAGCCGCAAGAGCAGTCCTGGGGCCCTGGACCCCTCTGTACAGTCCGTAGGAAAAA
GTCGGAATGCTCTCGACGGCCTCGTCCCAGCCTGGGACAGGCCCCCTTTCCCCTCTCTCTGCAGGCCAGGAGGGCCTCCTTCCTGCCACG
AGGGAGGGGAGTCGGGCCCCAGGTCGCCCCCGCCCCCAGCCCTGCATGCAGGTGCCCTCGCTCCGCCCCATCAGTTCCTGCCCCTGCCCC
TCATGCAGACTGCCCTGCTGGGGCCGGGCCGGAGGGTGGAGCAGAAAGGGGACCCCGGAGCCGAGCGAGGAGGACCAGGCAGCCGCCGCT
GCCGCGCTAAGCCACCACCTGCGCTTAGGTAGGCGTCCTGCTCGCCGACTTTCAGTTCCTTGGGAGGGTGTTGGGTGTCGTCCTTTTCAA
AAGTGTTTTGGAGCTTTCTGTGCCCCCCGACTTTCCCCCGCCTCCCCGCCCCCCACGTGGCCACTTTTCTCTGGATTTTAGCTGTAATGT
CTTTACTCTTTATTTAGGGGTGGGGCATTCATTGTTTGGGTCTTTTGCTGTTGGAATGGGAACTCCTCCTCCATTTGAGCAACTTGGGAA
CAATTTGGTAACACACCACAGGAAGTAGCTCTCCCCCCCAGCCCCCTCCTCCCTCAAGGGAGGGTTGGGGGGCCTGTCCAGAGGGTCTTC
AGAAGCCCCCCTGGGAGGGAGGGGAGGATGAGCACGCCCAGCTCCCCTCCAGGGTGTGACTTGGCCCCTCTGGCTTGTCTTTCTGTGCCT

>90951_90951_2_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000397661_length(amino acids)=447AA_BP=15
MAAAALRSGWCRCPRDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIR
PEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKE
LDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRR
SITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVL

--------------------------------------------------------------
>90951_90951_3_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000585575_length(transcript)=1796nt_BP=314nt
ACAGATCTGACCCTCCCAGGAGTGCCCTCCCCCGGGCCACATCCAGTCACGGGCCCCGTCCTTCCAAAACACTGCCCTATCAGAGGTCAA
GCTCTCTAGGCATTCCCTACCCTTTTAATGCCCCGCCCTATGACGGACCCAATCGGAGGGCTCTCCCTACCCGAAACCCCGCTCCTGGAG
CGGCTTTTCTCAGGCTTGCGCGGCTCTAGGCCGAAGCGGCGGATGACGCAACCGGGCCGCGCCGCGAGAAGGTCACACGATTCTCCAACA
TGGCGGCGGCGGCCCTGCGGAGTGGCTGGTGCCGCTGTCCACGGGATGAGTTCCACCCGTTCATCGAGGCACTGCTGCCTCACGTCCGCG
CTTTCTCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCATGAAAAGCGGATGTCGAAGGACGAGGAGCGGG
CGGTGAAGGACGAGCTGCTGGGCGAGAAGCCCGAGATCAAGCAGAAGTGGGCATCCCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGC
CCGAGTTCCGCGAGGACTTCGTGCTGACCATCACGGGCAAGAAGCCCCCCTGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATCC
GGCGGATTGACTGCCTGCGCCAGGCTGACAAGGTGTGGCGGCTGGACCTGGTCATGGTGATTTTGTTTAAGGGGATCCCCCTGGAAAGTA
CTGATGGGGAGCGGCTCTACAAGTCGCCTCAGTGCTCGAACCCCGGCCTGTGCGTCCAGCCACATCACATTGGAGTCACAATCAAAGAAC
TGGATCTTTATCTGGCTTACTTTGTCCACACTCCGGAATCCGGACAATCAGATAGTTCAAACCAGCAAGGAGATGCGGACATCAAACCAC
TGCCCAACGGGCACTTAAGTTTCCAGGACTGTTTTGTGACTTCCGGGGTCTGGAATGTGACGGAGCTGGTGAGAGTATCACAGACTCCTG
TTGCAACAGCATCAGGGCCCAACTTCTCCCTGGCGGACCTGGAGAGTCCCAGCTACTACAACATCAACCAGGTGACCCTGGGGCGGCGGT
CCATCACCTCCCCTCCTTCCACCAGCACCACCAAGCGCCCCAAGTCCATCGATGACAGTGAGATGGAGAGCCCTGTTGATGACGTGTTCT
ATCCCGGGACAGGCCGTTCCCCAGCAGCTGGCAGCAGCCAGTCCAGCGGGTGGCCCAACGATGTGGATGCAGGCCCGGCTTCTCTAAAGA
AGTCAGGAAAGCTGGACTTCTGCAGTGCCCTCTCCTCTCAGGGCAGCTCCCCGCGCATGGCTTTCACCCACCACCCGCTGCCTGTGCTTG
CTGGAGTCAGACCAGGGAGCCCCCGGGCCACAGCATCAGCCCTGCACTTCCCCTCCACGTCCATCATCCAGCAGTCGAGCCCGTATTTCA
CGCACCCGACCATCCGCTACCACCACCACCACGGGCAGGACTCACTGAAGGAGTTTGTGCAGTTTGTGTGCTCGGATGGCTCGGGCCAGG
CCACCGGACAGCCCAACGGTAGCGGCCAGGGCAAAGTCCCGGGGTCATTTTTGCTACCGCCGCCGCCTCCAGTGGCCAGACCTGTGCCCC
TTCCTATGCCTGATTCCAAATCCACCAGCACTGCCCCAGACGGCGCCGCCTTGACTCCTCCATCACCTTCATTCGCAACGACAGGCGCCT

>90951_90951_3_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000585575_length(amino acids)=509AA_BP=15
MAAAALRSGWCRCPRDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIR
PEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKE
LDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRR
SITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVL
AGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQPNGSGQGKVPGSFLLPPPPPVARPVP

--------------------------------------------------------------
>90951_90951_4_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000587760_length(transcript)=1757nt_BP=314nt
ACAGATCTGACCCTCCCAGGAGTGCCCTCCCCCGGGCCACATCCAGTCACGGGCCCCGTCCTTCCAAAACACTGCCCTATCAGAGGTCAA
GCTCTCTAGGCATTCCCTACCCTTTTAATGCCCCGCCCTATGACGGACCCAATCGGAGGGCTCTCCCTACCCGAAACCCCGCTCCTGGAG
CGGCTTTTCTCAGGCTTGCGCGGCTCTAGGCCGAAGCGGCGGATGACGCAACCGGGCCGCGCCGCGAGAAGGTCACACGATTCTCCAACA
TGGCGGCGGCGGCCCTGCGGAGTGGCTGGTGCCGCTGTCCACGGGATGAGTTCCACCCGTTCATCGAGGCACTGCTGCCTCACGTCCGCG
CTTTCTCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCATGAAAAGCGGATGTCGAAGGACGAGGAGCGGG
CGGTGAAGGACGAGCTGCTGGGCGAGAAGCCCGAGATCAAGCAGAAGTGGGCATCCCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGC
CCGAGTTCCGCGAGGACTTCGTGCTGACCATCACGGGCAAGAAGCCCCCCTGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATCC
GGCGGATTGACTGCCTGCGCCAGGCTGACAAGGTGTGGCGGCTGGACCTGGTCATGGTGATTTTGTTTAAGGGGATCCCCCTGGAAAGTA
CTGATGGGGAGCGGCTCTACAAGTCGCCTCAGTGCTCGAACCCCGGCCTGTGCGTCCAGCCACATCACATTGGAGTCACAATCAAAGAAC
TGGATCTTTATCTGGCTTACTTTGTCCACACTCCGGAATCCGGACAATCAGATAGTTCAAACCAGCAAGGAGATGCGGACATCAAACCAC
TGCCCAACGGGCACTTAAGTTTCCAGGACTGTTTTGTGACTTCCGGGGTCTGGAATGTGACGGAGCTGGTGAGAGTATCACAGACTCCTG
TTGCAACAGCATCAGGGCCCAACTTCTCCCTGGCGGACCTGGAGAGTCCCAGCTACTACAACATCAACCAGGTGACCCTGGGGCGGCGGT
CCATCACCTCCCCTCCTTCCACCAGCACCACCAAGCGCCCCAAGTCCATCGATGACAGTGAGATGGAGAGCCCTGTTGATGACGTGTTCT
ATCCCGGGACAGGCCGTTCCCCAGCAGCTGGCAGCAGCCAGTCCAGCGGGTGGCCCAACGATGTGGATGCAGGCCCGGCTTCTCTAAAGA
AGTCAGGAAAGCTGGACTTCTGCAGTGCCCTCTCCTCTCAGGGCAGCTCCCCGCGCATGGCTTTCACCCACCACCCGCTGCCTGTGCTTG
CTGGAGTCAGACCAGGGAGCCCCCGGGCCACAGCATCAGCCCTGCACTTCCCCTCCACGTCCATCATCCAGCAGTCGAGCCCGTATTTCA
CGCACCCGACCATCCGCTACCACCACCACCACGGGCAGGACTCACTGAAGGAGTTTGTGCAGTTTGTGTGCTCGGATGGCTCGGGCCAGG
CCACCGGACAGCATTCGCAACGACAGGCGCCTCCTCTGCCAACCGGTTTGTCAGCATCGGACCCCGGGACGGCAACTTTCTGAACATCCC
ACAGCAGTCTCAGTCCTGGTTCCTCTGATAAGATCGACAAAAGAAACAACAAAATGAGAAGAAGAGGTTCCTCGAAAGGGGGGAGAAGAA

>90951_90951_4_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000587760_length(amino acids)=447AA_BP=15
MAAAALRSGWCRCPRDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIR
PEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKE
LDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRR
SITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVL

--------------------------------------------------------------
>90951_90951_5_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000592199_length(transcript)=1796nt_BP=314nt
ACAGATCTGACCCTCCCAGGAGTGCCCTCCCCCGGGCCACATCCAGTCACGGGCCCCGTCCTTCCAAAACACTGCCCTATCAGAGGTCAA
GCTCTCTAGGCATTCCCTACCCTTTTAATGCCCCGCCCTATGACGGACCCAATCGGAGGGCTCTCCCTACCCGAAACCCCGCTCCTGGAG
CGGCTTTTCTCAGGCTTGCGCGGCTCTAGGCCGAAGCGGCGGATGACGCAACCGGGCCGCGCCGCGAGAAGGTCACACGATTCTCCAACA
TGGCGGCGGCGGCCCTGCGGAGTGGCTGGTGCCGCTGTCCACGGGATGAGTTCCACCCGTTCATCGAGGCACTGCTGCCTCACGTCCGCG
CTTTCTCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCATGAAAAGCGGATGTCGAAGGACGAGGAGCGGG
CGGTGAAGGACGAGCTGCTGGGCGAGAAGCCCGAGATCAAGCAGAAGTGGGCATCCCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGC
CCGAGTTCCGCGAGGACTTCGTGCTGACCATCACGGGCAAGAAGCCCCCCTGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATCC
GGCGGATTGACTGCCTGCGCCAGGCTGACAAGGTGTGGCGGCTGGACCTGGTCATGGTGATTTTGTTTAAGGGGATCCCCCTGGAAAGTA
CTGATGGGGAGCGGCTCTACAAGTCGCCTCAGTGCTCGAACCCCGGCCTGTGCGTCCAGCCACATCACATTGGAGTCACAATCAAAGAAC
TGGATCTTTATCTGGCTTACTTTGTCCACACTCCGGAATCCGGACAATCAGATAGTTCAAACCAGCAAGGAGATGCGGACATCAAACCAC
TGCCCAACGGGCACTTAAGTTTCCAGGACTGTTTTGTGACTTCCGGGGTCTGGAATGTGACGGAGCTGGTGAGAGTATCACAGACTCCTG
TTGCAACAGCATCAGGGCCCAACTTCTCCCTGGCGGACCTGGAGAGTCCCAGCTACTACAACATCAACCAGGTGACCCTGGGGCGGCGGT
CCATCACCTCCCCTCCTTCCACCAGCACCACCAAGCGCCCCAAGTCCATCGATGACAGTGAGATGGAGAGCCCTGTTGATGACGTGTTCT
ATCCCGGGACAGGCCGTTCCCCAGCAGCTGGCAGCAGCCAGTCCAGCGGGTGGCCCAACGATGTGGATGCAGGCCCGGCTTCTCTAAAGA
AGTCAGGAAAGCTGGACTTCTGCAGTGCCCTCTCCTCTCAGGGCAGCTCCCCGCGCATGGCTTTCACCCACCACCCGCTGCCTGTGCTTG
CTGGAGTCAGACCAGGGAGCCCCCGGGCCACAGCATCAGCCCTGCACTTCCCCTCCACGTCCATCATCCAGCAGTCGAGCCCGTATTTCA
CGCACCCGACCATCCGCTACCACCACCACCACGGGCAGGACTCACTGAAGGAGTTTGTGCAGTTTGTGTGCTCGGATGGCTCGGGCCAGG
CCACCGGACAGCCCAACGGTAGCGGCCAGGGCAAAGTCCCGGGGTCATTTTTGCTACCGCCGCCGCCTCCAGTGGCCAGACCTGTGCCCC
TTCCTATGCCTGATTCCAAATCCACCAGCACTGCCCCAGACGGCGCCGCCTTGACTCCTCCATCACCTTCATTCGCAACGACAGGCGCCT

>90951_90951_5_TIMM44-NFIX_TIMM44_chr19_8008492_ENST00000270538_NFIX_chr19_13135835_ENST00000592199_length(amino acids)=509AA_BP=15
MAAAALRSGWCRCPRDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIR
PEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKE
LDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRR
SITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVL
AGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQPNGSGQGKVPGSFLLPPPPPVARPVP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TIMM44-NFIX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TIMM44-NFIX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TIMM44-NFIX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource