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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TJAP1-ABCC10 (FusionGDB2 ID:91035)

Fusion Gene Summary for TJAP1-ABCC10

check button Fusion gene summary
Fusion gene informationFusion gene name: TJAP1-ABCC10
Fusion gene ID: 91035
HgeneTgene
Gene symbol

TJAP1

ABCC10

Gene ID

93643

89845

Gene nametight junction associated protein 1ATP binding cassette subfamily C member 10
SynonymsPILT|TJP4EST182763|MRP7|SIMRP7
Cytomap

6p21.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptiontight junction-associated protein 1protein incorporated later into tight junctionstight junction associated protein 1 (peripheral)tight junction protein 4 (peripheral)multidrug resistance-associated protein 7ATP-binding cassette sub-family C member 10ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Modification date2020031320200313
UniProtAcc.

Q5T3U5

Ensembl transtripts involved in fusion geneENST00000259751, ENST00000372444, 
ENST00000372445, ENST00000372449, 
ENST00000372452, ENST00000436109, 
ENST00000438588, ENST00000483640, 
ENST00000372530, ENST00000244533, 
ENST00000443426, 
Fusion gene scores* DoF score5 X 7 X 3=1052 X 3 X 2=12
# samples 63
** MAII scorelog2(6/105*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TJAP1 [Title/Abstract] AND ABCC10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTJAP1(43446456)-ABCC10(43409600), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TJAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABCC10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8353-01ATJAP1chr6

43446456

-ABCC10chr6

43409600

+
ChimerDB4LUSCTCGA-85-8353-01ATJAP1chr6

43446456

+ABCC10chr6

43409600

+
ChimerDB4LUSCTCGA-85-8353TJAP1chr6

43445366

+ABCC10chr6

43411671

+
ChimerDB4LUSCTCGA-85-8353TJAP1chr6

43445970

+ABCC10chr6

43409600

+
ChimerDB4LUSCTCGA-85-8353TJAP1chr6

43446456

+ABCC10chr6

43409600

+


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Fusion Gene ORF analysis for TJAP1-ABCC10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000259751ENST00000372530TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-3CDSENST00000259751ENST00000372530TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-3CDSENST00000372444ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
5UTR-3CDSENST00000372444ENST00000372530TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-3CDSENST00000372444ENST00000372530TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-3CDSENST00000372445ENST00000372530TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-3CDSENST00000372445ENST00000372530TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-3CDSENST00000372449ENST00000372530TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-3CDSENST00000372449ENST00000372530TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-3CDSENST00000372452ENST00000372530TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-3CDSENST00000372452ENST00000372530TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-3CDSENST00000436109ENST00000372530TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000259751ENST00000244533TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000259751ENST00000244533TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000259751ENST00000443426TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000259751ENST00000443426TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000372444ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
5UTR-intronENST00000372444ENST00000244533TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000372444ENST00000244533TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000372444ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
5UTR-intronENST00000372444ENST00000443426TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000372444ENST00000443426TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000372445ENST00000244533TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000372445ENST00000244533TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000372445ENST00000443426TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000372445ENST00000443426TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000372449ENST00000244533TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000372449ENST00000244533TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000372449ENST00000443426TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000372449ENST00000443426TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000372452ENST00000244533TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000372452ENST00000244533TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000372452ENST00000443426TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000372452ENST00000443426TJAP1chr6

43445970

+ABCC10chr6

43409600

+
5UTR-intronENST00000436109ENST00000244533TJAP1chr6

43445366

+ABCC10chr6

43411671

+
5UTR-intronENST00000436109ENST00000443426TJAP1chr6

43445366

+ABCC10chr6

43411671

+
intron-3CDSENST00000259751ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000372445ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000372449ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000372452ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000436109ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000436109ENST00000372530TJAP1chr6

43445970

+ABCC10chr6

43409600

+
intron-3CDSENST00000438588ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000438588ENST00000372530TJAP1chr6

43445366

+ABCC10chr6

43411671

+
intron-3CDSENST00000438588ENST00000372530TJAP1chr6

43445970

+ABCC10chr6

43409600

+
intron-3CDSENST00000483640ENST00000372530TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-3CDSENST00000483640ENST00000372530TJAP1chr6

43445366

+ABCC10chr6

43411671

+
intron-3CDSENST00000483640ENST00000372530TJAP1chr6

43445970

+ABCC10chr6

43409600

+
intron-intronENST00000259751ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000259751ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372445ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372445ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372449ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372449ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372452ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000372452ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000436109ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000436109ENST00000244533TJAP1chr6

43445970

+ABCC10chr6

43409600

+
intron-intronENST00000436109ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000436109ENST00000443426TJAP1chr6

43445970

+ABCC10chr6

43409600

+
intron-intronENST00000438588ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000438588ENST00000244533TJAP1chr6

43445366

+ABCC10chr6

43411671

+
intron-intronENST00000438588ENST00000244533TJAP1chr6

43445970

+ABCC10chr6

43409600

+
intron-intronENST00000438588ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000438588ENST00000443426TJAP1chr6

43445366

+ABCC10chr6

43411671

+
intron-intronENST00000438588ENST00000443426TJAP1chr6

43445970

+ABCC10chr6

43409600

+
intron-intronENST00000483640ENST00000244533TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000483640ENST00000244533TJAP1chr6

43445366

+ABCC10chr6

43411671

+
intron-intronENST00000483640ENST00000244533TJAP1chr6

43445970

+ABCC10chr6

43409600

+
intron-intronENST00000483640ENST00000443426TJAP1chr6

43446456

+ABCC10chr6

43409600

+
intron-intronENST00000483640ENST00000443426TJAP1chr6

43445366

+ABCC10chr6

43411671

+
intron-intronENST00000483640ENST00000443426TJAP1chr6

43445970

+ABCC10chr6

43409600

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for TJAP1-ABCC10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TJAP1chr643446456+ABCC10chr643409599+0.9194310.08056905
TJAP1chr643446456+ABCC10chr643409599+0.9194310.08056905
TJAP1chr643445970+ABCC10chr643409599+0.0206275820.97937244
TJAP1chr643445366+ABCC10chr643411670+5.88E-050.99994123
TJAP1chr643446456+ABCC10chr643409599+0.9194310.08056905
TJAP1chr643446456+ABCC10chr643409599+0.9194310.08056905
TJAP1chr643445970+ABCC10chr643409599+0.0206275820.97937244
TJAP1chr643445366+ABCC10chr643411670+5.88E-050.99994123

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TJAP1-ABCC10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:43446456/:43409600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ABCC10

Q5T3U5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806). {ECO:0000269|PubMed:12527806, ECO:0000269|PubMed:15256465, ECO:0000269|PubMed:23087055}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for TJAP1-ABCC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for TJAP1-ABCC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TJAP1-ABCC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TJAP1-ABCC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource