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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TKT-DOCK3 (FusionGDB2 ID:91085)

Fusion Gene Summary for TKT-DOCK3

check button Fusion gene summary
Fusion gene informationFusion gene name: TKT-DOCK3
Fusion gene ID: 91085
HgeneTgene
Gene symbol

TKT

DOCK3

Gene ID

7086

1795

Gene nametransketolasededicator of cytokinesis 3
SynonymsHEL-S-48|HEL107|SDDHD|TK|TKT1MOCA|NEDIDHA|PBP
Cytomap

3p21.1

3p21.2

Type of geneprotein-codingprotein-coding
Descriptiontransketolaseepididymis luminal protein 107epididymis secretory protein Li 48dedicator of cytokinesis protein 3modifier of cell adhesionpresenilin-binding protein
Modification date2020031320200313
UniProtAcc.

Q8IZD9

Ensembl transtripts involved in fusion geneENST00000296289, ENST00000423516, 
ENST00000423525, ENST00000462138, 
ENST00000461139, 		ENST00000266037, 
Fusion gene scores* DoF score10 X 12 X 4=48012 X 10 X 7=840
# samples 1412
** MAII scorelog2(14/480*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/840*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TKT [Title/Abstract] AND DOCK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDOCK3(50712731)-TKT(53276258), # samples:1
TKT(53289852)-DOCK3(50971412), # samples:1
TKT(53289852)-DOCK3(50927457), # samples:1
Anticipated loss of major functional domain due to fusion event.DOCK3-TKT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DOCK3-TKT seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TKT-DOCK3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TKT-DOCK3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTKT

GO:0046166

glyceraldehyde-3-phosphate biosynthetic process

9611778


check buttonFusion gene breakpoints across TKT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DOCK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8531-01ATKTchr3

53289852

-DOCK3chr3

50927457

+
ChimerDB4STADTCGA-CD-8531-01ATKTchr3

53289852

-DOCK3chr3

50971412

+


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Fusion Gene ORF analysis for TKT-DOCK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000296289ENST00000266037TKTchr3

53289852

-DOCK3chr3

50927457

+
5UTR-3CDSENST00000296289ENST00000266037TKTchr3

53289852

-DOCK3chr3

50971412

+
Frame-shiftENST00000423516ENST00000266037TKTchr3

53289852

-DOCK3chr3

50971412

+
Frame-shiftENST00000423525ENST00000266037TKTchr3

53289852

-DOCK3chr3

50971412

+
Frame-shiftENST00000462138ENST00000266037TKTchr3

53289852

-DOCK3chr3

50971412

+
In-frameENST00000423516ENST00000266037TKTchr3

53289852

-DOCK3chr3

50927457

+
In-frameENST00000423525ENST00000266037TKTchr3

53289852

-DOCK3chr3

50927457

+
In-frameENST00000462138ENST00000266037TKTchr3

53289852

-DOCK3chr3

50927457

+
intron-3CDSENST00000461139ENST00000266037TKTchr3

53289852

-DOCK3chr3

50927457

+
intron-3CDSENST00000461139ENST00000266037TKTchr3

53289852

-DOCK3chr3

50971412

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462138TKTchr353289852-ENST00000266037DOCK3chr350927457+876619622361261967
ENST00000423525TKTchr353289852-ENST00000266037DOCK3chr350927457+873516519260951967
ENST00000423516TKTchr353289852-ENST00000266037DOCK3chr350927457+875718721461171967

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462138ENST00000266037TKTchr353289852-DOCK3chr350927457+0.0008614940.9991385
ENST00000423525ENST00000266037TKTchr353289852-DOCK3chr350927457+0.0008277020.99917233
ENST00000423516ENST00000266037TKTchr353289852-DOCK3chr350927457+0.0008536550.99914634

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Fusion Genomic Features for TKT-DOCK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TKTchr353289851-DOCK3chr350971411+8.25E-070.99999917
TKTchr353289851-DOCK3chr350927456+3.59E-101
TKTchr353289851-DOCK3chr350971411+8.25E-070.99999917
TKTchr353289851-DOCK3chr350927456+3.59E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TKT-DOCK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:50712731/chr3:53276258)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DOCK3

Q8IZD9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDOCK3chr3:53289852chr3:50927457ENST000002660372531731_1768542031.0Compositional biasNote=Ser-rich
TgeneDOCK3chr3:53289852chr3:50927457ENST000002660372531228_1635542031.0DomainDOCKER
TgeneDOCK3chr3:53289852chr3:50927457ENST00000266037253421_599542031.0DomainC2 DOCK-type
TgeneDOCK3chr3:53289852chr3:50927457ENST000002660372531970_1976542031.0MotifSH3-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTKTchr3:53289852chr3:50927457ENST00000423516-115123_12535632.0Nucleotide bindingNote=Thiamine pyrophosphate
HgeneTKTchr3:53289852chr3:50927457ENST00000423525-115123_12535888.6666666666666Nucleotide bindingNote=Thiamine pyrophosphate
HgeneTKTchr3:53289852chr3:50927457ENST00000462138-114123_12535624.0Nucleotide bindingNote=Thiamine pyrophosphate
TgeneDOCK3chr3:53289852chr3:50927457ENST000002660372536_67542031.0DomainSH3


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Fusion Gene Sequence for TKT-DOCK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91085_91085_1_TKT-DOCK3_TKT_chr3_53289852_ENST00000423516_DOCK3_chr3_50927457_ENST00000266037_length(transcript)=8757nt_BP=187nt
CTCGGCAGCCGCCTGTCGCCGCGGGAGCAGCCGCTATCTCTGTGTGTCCGCGTGTGCGCCCGGTCCCCGCCTGCCGCACCATGGAGAGCT
ACCACAAGCCTGACCAGCAGAAGCTGCAGGCCTTGAAGGACACGGCCAACCGCCTACGTATCAGCTCCATCCAGGCCACCACTGCGGCGG
GCTCTGGGGGATCTTTCCTGCAAATTACATTCACTTGAAAAAGGCAATTGTCAGTAATAGGGGGCAGTATGAAACTGTGGTTCCACTTGA
AGATTCTATTGTGACTGAGGTTACAGCAACTCTACAAGAATGGGCAAGTTTGTGGAAACAGTTGTATGTGAAACACAAAGTAGATCTTTT
CTACAAACTACGCCATGTGATGAATGAACTTATTGACCTGCGAAGGCAGCTACTGTCTGGTCACCTGACTCAGGATCAGGTGCGGGAGGT
TAAGCGGCACATCACCGTGCGCCTGGACTGGGGTAATGAACATTTGGGCCTGGACCTGGTGCCTCGGAAGGACTTTGAAGTAGTGGACTC
GGACCAGATTAGTGTCTCAGATCTCTATAAGATGCATTTATCTAGCCGGCAGAGTGTACAGCAAAGCACATCCCAGGTAGATACAATGCG
CCCACGTCATGGGGAAACATGTCGGATGCCAGTGCCACATCACTTCTTCCTCAGCCTGAAGAGTTTCACTTACAATACTATTGGGGAAGA
TACCGATGTCTTCTTTTCCTTATATGACATGAGGGAAGGCAAGCAGATCAGTGAGCGGTTTCTGGTAAGACTGAACAAGAATGGTGGGCC
GAGGAACCCAGAGAAGATAGAACGAATGTGTGCCCTTTTTACAGATCTGAGCAGCAAAGATATGAAGAGAGATTTGTATATCGTTGCCCA
TGTGATCCGAATAGGCCGGATGCTCCTGAACGACTCAAAGAAAGGTCCTCCTCACCTGCACTACAGGCGACCATATGGCTGTGCGGTCCT
AAGCATCTTGGATGTCCTACAGTCACTCACAGAAGTAAAGGAAGAAAAGGATTTTGTTCTTAAGGTTTACACGTGCAACAACGAGAGTGA
GTGGTCCCAGATCCACGAGAACATCATCCGAAAGTCCAGTGCCAAGTACTCTGCCCCCAGCGCCAGCCATGGTCTTATCATTTCTCTGCA
GCTTCTTCGTGGAGACATGGAACAGATTCGGAGAGAAAATCCCATGATATTTAATAGGGGATTGGCAATTACAAGAAAATTGGGATTTCC
TGATGTCATTATGCCAGGTGATATCCGCAATGACCTGTACCTAACCCTGGAGAAGGGGGATTTCGAGAGAGGAGGAAAGAGTGTACAAAA
GAATATTGAAGTGACCATGTATGTGCTTTATGCAGATGGAGAAATCTTGAAGGATTGCATCAGCTTGGGTTCAGGAGAGCCAAATAGGAG
TTCCTACCACTCCTTTGTCCTCTACCACAGTAATAGTCCTCGCTGGGGAGAAATTATCAAATTGCCTATCCCCATTGACCGGTTCCGGGG
CTCCCACCTGCGCTTTGAGTTCAGACATTGTTCCACAAAGGACAAAGGGGAAAAGAAACTCTTTGGCTTTGCATTCTCAACCCTGATGCG
TGATGATGGCACCACCCTCTCAGATGATATTCACGAGCTTTATGTGTACAAGTGTGATGAGAATAGCACGTTTAATAACCATGCTCTGTA
CCTGGGCCTGCCCTGCTGCAAAGAGGACTACAATGGCTGCCCTAATATTCCTTCTAGCCTCATCTTCCAGCGCAGCACCAAAGAGTCTTT
CTTCATCTCCACTCAGCTCTCCTCTACCAAACTCACCCAGAATGTGGACCTCCTAGCTCTGCTGAAGTGGAAAGCCTTCCCCGACCGGAT
CATGGATGTACTAGGGCGGCTGCGGCATGTCAGTGGGGAGGAAATTGTTAAGTTTCTGCAGGACATCTTAGATACACTCTTTGTGATTTT
GGATGATAATACAGAGAAGTACGGCCTGTTGGTTTTTCAGTCTCTGGTGTTCATCATCAACCTGCTCCGAGACATCAAGTATTTTCACTT
TCGACCTGTGATGGACACGTATATCCAGAAGCACTTTGCTGGAGCTCTGGCATACAAGGAGCTCATCCGCTGTTTGAAGTGGTATATGGA
CTGCTCAGCAGAACTGATTCGACAGGACCACATTCAAGAAGCTATGCGGGCCTTGGAGTACCTTTTCAAGTTCATTGTACAGTCACGGAT
CCTGTACTCACGAGCCACTTGTGGAATGGAAGAGGAACAATTCAGATCCAGTATCCAAGAACTTTTCCAGTCCATCCGGTTTGTGCTCAG
TCTGGACAGCCGAAACTCAGAAACACTCCTTTTTACTCAGGCTGCACTCCTCAATTCTTTCCCAACCATCTTTGATGAGCTTCTGCAAAT
GTTCACCGTGCAAGAGGTGGCAGAGTTTGTGAGAGGGACACTGGGGAGCATGCCCAGCACTGTGCACATTGGGCAGTCAATGGACGTGGT
CAAGCTGCAGTCCATTGCCAGGACAGTGGATAGCCGCCTGTTTTCTTTCTCAGAATCCCGCCGCATCCTGCTTCCTGTGGTTCTCCATCA
CATTCACCTTCACCTGAGGCAGCAGAAAGAGCTGCTAATTTGCTCAGGGATTCTTGGCAGCATCTTCTCCATCGTCAAGACCAGCTCTCT
GGAGGCAGATGTCATGGAGGAAGTAGAGATGATGGTGGAGAGCCTCCTGGACGTGCTCTTGCAGACTCTGCTCACCATCATGAGCAAATC
GCACGCTCAGGAGGCGGTAAGAGGGCAGCGGTGCCCGCAGTGCACAGCCGAGATCACTGGCGAGTATGTGTCCTGCCTTCTCTCACTGCT
CCGCCAGATGTGTGACACCCATTTCCAGCACCTCCTGGACAACTTCCAGAGCAAAGATGAACTCAAGGAATTTCTGCTGAAGATTTTTTG
CGTGTTCCGGAACCTGATGAAGATGAGTGTCTTCCCTCGGGACTGGATGGTAATGAGACTGCTCACAAGCAATATTATAGTCACTACTGT
CCAGTACCTGTCCTCTGCACTGCACAAGAATTTCACAGAGACTGACTTTGACTTTAAGGTGTGGAATTCTTACTTTAGCCTGGCAGTTCT
ATTCATAAATCAGCCAAGCCTTCAGCTAGAAATTATCACCTCAGCCAAAAGGAAGAAGATTCTAGATAAGTATGGGGACATGCGTGTAAT
GATGGCCTATGAACTGTTCAGCATGTGGCAGAATTTGGGTGAACATAAGATCCACTTTATTCCGGGAATGATTGGTCCTTTTCTGGGTGT
GACACTGGTCCCACAGCCAGAAGTACGGAATATCATGATTCCCATCTTTCATGACATGATGGACTGGGAGCAGAGAAAAAATGGCAACTT
CAAACAGGTGGAGGCCGAGTTGATTGACAAGCTGGACAGCATGGTGTCAGAAGGGAAAGGTGACGAGAGCTACAGGGAGCTCTTCAGCCT
ACTAACCCAGCTGTTTGGGCCCTACCCCAGCCTGCTGGAGAAGGTTGAACAAGAAACATGGCGCGAGACCGGCATTTCCTTTGTGACCTC
AGTCACCCGCCTCATGGAACGTCTTCTTGACTACAGGGACTGCATGAAAGGAGAGGAAACAGAGAATAAGAAGATAGGCTGCACTGTTAA
CCTGATGAATTTTTACAAATCTGAGATTAACAAGGAAGAAATGTATATCCGCTACATCCATAAGCTTTGTGACATGCACTTGCAGGCCGA
AAACTACACAGAGGCCGCATTTACCCTGCTCCTTTACTGTGAGCTGCTGCAGTGGGAGGACCGGCCACTACGGGAATTCCTCCACTACCC
ATCGCAGACAGAGTGGCAGCGGAAGGAGGGACTGTGCCGGAAGATCATTCACTACTTCAACAAAGGCAAGAGCTGGGAGTTTGGGATCCC
ACTGTGCAGGGAGCTGGCGTGTCAGTACGAGAGCCTCTATGATTACCAGAGCCTCAGCTGGATTCGGAAAATGGAGGCCAGCTACTATGA
CAACATTATGGAGCAGCAACGCCTGGAGCCTGAGTTCTTTCGGGTCGGCTTCTATGGCAGGAAGTTTCCTTTCTTTCTTCGGAACAAAGA
ATACGTGTGCCGTGGCCATGACTACGAGAGGCTGGAGGCCTTCCAGCAGAGGATGCTCAGTGAGTTTCCGCAGGCTGTCGCCATGCAGCA
CCCCAACCATCCTGATGACGCCATCCTACAGTGCGATGCCCAGTACTTGCAGATCTATGCAGTGACGCCCATTCCAGATTATGTGGATGT
TCTGCAGATGGATAGGGTACCAGATCGAGTCAAGAGCTTCTATCGCGTCAACAATGTGAGGAAGTTCCGGTATGACAGGCCTTTTCACAA
AGGCCCCAAGGACAAGGAGAATGAATTCAAGAGCCTGTGGATTGAACGTACCACACTGACCCTGACCCACAGCTTGCCTGGCATCTCTCG
GTGGTTTGAAGTGGAGAGGAGGGAACTGGTGGAGGTGAGCCCTCTGGAGAATGCCATCCAAGTGGTTGAGAATAAGAACCAGGAGCTACG
CTCCCTGATCAGCCAGTATCAACACAAGCAGGTGCATGGCAACATTAACCTGCTAAGCATGTGCCTGAATGGTGTCATTGATGCAGCTGT
CAATGGAGGCATTGCACGCTATCAGGAGGCCTTCTTTGATAAAGATTACATCAACAAGCACCCAGGAGATGCTGAGAAGATCACCCAGCT
CAAGGAGCTTATGCAGGAGCAGGTTCATGTCCTTGGAGTTGGGCTAGCAGTTCATGAGAAGTTTGTGCACCCAGAAATGCGGCCTCTGCA
TAAGAAGCTAATTGATCAGTTCCAGATGATGCGGGCCAGTCTCTACCATGAGTTTCCAGGTTTGGATAAGCTAAGTCCTGCATGTTCAGG
CACCAGCACCCCACGGGGAAATGTTCTGGCATCCCATAGCCCCATGAGTCCGGAGAGCATCAAGATGACCCACCGGCACAGCCCCATGAA
CTTGATGGGCACAGGCCGCCATTCATCATCCTCTCTCTCCTCACATGCGTCTAGTGAAGCAGGAAACATGGTGATGCTGGGTGACGGCTC
CATGGGTGATGCTCCTGAGGACCTGTACCACCACATGCAGCTCGCGTATCCCAACCCCAGGTACCAAGGCTCAGTCACCAACGTCTCTGT
TCTGTCCTCGTCCCAGGCAAGCCCTTCTTCCTCCAGCCTGAGTTCCACTCACTCAGCACCATCCCAGATGATTACCTCTGCCCCTTCCAG
TGCCCGAGGCTCTCCCTCTCTGCCAGATAAGTACCGCCATGCCCGTGAAATGATGTTGTTGCTGCCCACATACCGGGACCGCCCAAGCAG
TGCCATGTATCCAGCAGCCATCCTGGAGAACGGACAGCCGCCGAATTTCCAGCGAGCCCTGTTCCAGCAAGTGGTCGGAGCCTGCAAACC
CTGCAGTGATCCCAATCTGTCTGTGGCTGAAAAAGGTCATTACTCCCTACACTTTGACGCCTTCCACCACCCTCTGGGTGATACCCCCCC
AGCCCTCCCTGCCCGGACCCTGCGCAAGTCTCCTCTCCACCCTATCCCAGCCTCCCCCACAAGCCCCCAGTCAGGTCTGGACGGCAGCAA
CTCTACGCTGTCCGGCAGTGCCAGCAGCGGCGTGTCCTCCTTGAGTGAGAGTAACTTTGGGCACTCCTCGGAGGCCCCACCTCGCACTGA
CACCATGGACTCCATGCCAAGTCAGGCCTGGAATGCTGACGAAGATCTTGAGCCACCCTACCTCCCTGTCCACTACAGCCTCTCTGAGTC
TGCCGTCCTGGACTCCATCAAGGCCCAGCCATGCCGAAGCCACTCAGCCCCAGGGTGCGTCATCCCTCAGGACCCCATGGACCCGCCTGC
GCTGCCGCCCAAGCCCTACCACCCCCGCCTGCCGGCCCTGGAGCACGATGAGGGGGTGCTGCTGCGTGAAGAGACTGAGAGGCCTCGAGG
CCTGCACCGCAAGGCTCCATTGCCTCCTGGGAGCGCTAAGGAGGAGCAGGCCCGCATGGCCTGGGAGCACGGCCGAGGGGAGCAGTGAGG
GGCAACGAGGCGGCTGGGATGCCGCCCTCAGTAAGCAGCTTGCCAATCACTCCAGGTCTGAAAAGCAAGTCCCCCAGCCCCACCCCAGGG
AGCCAGAGAGGCTTGCACTCAGGAGAGAACCACCCCCAAGTCTCCGTTCTACTGCCGTGAACTCATGTGTTGCCATGTACAGAGGCCACA
GCAGCATGAAGGGTTGTGGCTTCCCTTTTTATTTTTTTACATTTCCATTTCTATGGGTTTTCCTTTCTTTCCTTTATGCAGTAGATGCTT
TCTTCCTCCTGCAGTTCTGGACCATGTGGAGCTACATGGAGAAATTGCACAGACAGAATCACTTTGCCACACTGCAGGGCCCAGGAGTGG
GAGCCCAGGCCCTCCCTCCAGGGTAGAGATGCACCGAATGGAAATTGCACTAAGGACCTCTTCCTTTGCTGTATGGACAGAAGAGTTCAT
GGTTGCATTCAGGGATTGCAAGGACCATATAGACATGTCACAGGTGGAAAAAGGGCCACAAGCCGTTTTGCACAAATGCCTGCCCACCTG
CCCCTCTTCCATCCAGGAGTGTGCTACTGAGGGGCTGGCTGGACCAACCTGCTGGCTCAGGCATGTGACTGGCCTAACTGCATGCCCAGG
GCACTGCCAGGGTTCAATGGGCCAGCCGTCTCCTACTCCACCTTGGATTTTTCTCTCCATCACATCATTTCTGACCATTTGCTCCCTTCC
ATTCTTGAAACACCTCATGCCCCACAGGAGCCCCAGTGGTGACTGGATCTGCAAGGGTTATCTCCCGCCCTCTGGGGTTTGAGTGGAGGT
ATGGAGCCAGAGAGGCTATCCTAGCTACCTTCCTCCTAGGGGGAGCTGGTCCCCTTCCTATGTGGTAGAGAGACTGGTGTAAGAGTGTGG
GGTGTGGCAGGCGCCGGAAATCCTCAAAGCTTTCAGAAGCATCCAGAATGCCTACCATCAGCTCCTGAATCAGGGATTTTCAGCACTACC
TCTGAGCCATGGGGTTGGCTGCCCAGCCAGGCTTCCAGGCCCTGAGGACATGTGGTCAGGTTCAGCAGGCTCCTGGGTAAAGAGGGTGGG
AGGGGGCTTCTCCTTTTGGAAGCAGATAGCCATGCAGGTAGAATTGTCATCTCCCAAGTGGCCACATACAGCAACCCACTCCAGGCCATG
GGGACCACCACTCAGGGTTCGGGGCTGGCAGGAGGGTAGTTTCTCCAGTCTCCCCAGTCTGTTGGTGTCTTTATAGGAAACTATAAAGCA
GAGCAGTGGTGTCTTTAGAGGAAACTCATTCAAGTCAGGGCACTGATTTTCCTCTCAGTTTATTATTTGGGGGGATAGGGTCAGGTGGGT
ATAGTAGTACTTTACCAGGGTGCTTTTAAGTTACTTTAAAAAAAGCCTACAAAATATTTTTTTTCTTTTATTTGCTCGAGTTCACATTAA
TGATGGTCACAAGGCTGCCTTGTTGGGCAGGCGTATTGCCCCCAGTTCCTCTTCTGCTGGCCTGTATGACCTCCACAGCCAGGCCCTGGG
CCCAAGCCCCTTGTCCCTTCTCCACTGCCCCTCTTTCCAGACAGTAAAGGCCATGGTCAGTGTGTTTTTCTCTTGTAAACAAACCCCAGC
TTGTTTAACAGAAATGCTAATAACCTACTGGGAAAGATGGAGGTCTAAATTACCTCCAGGGTTTTTCTGGGGGTTTATCACCAGTGTGGG
TCCCTTCTGATACCACCAGGTTCACTCCAGGCAGAGTGGGGCGGAAGGCTGCTGAGGATATGGGTCAGTTACAGCAGCCCTCACCTCAAA
GGGCTGGCCTGCTTCTCAGCCTACATTCATTTGCAAGCTTCAATCTCTGGACCATCTGGTGTTCACAGGTGTTAGAGGGTTAGGGGTTAG
GGGCTAGTTTTGGATTTGATTCATAGGTAGGAGGGCTTAGATTTTAAGGCACTTCTGAAAGTCAATCCCTGGACAAGGCAGTCATCACAT
AAGAACAGCTACCTTCTCCACTTGGTGGCACAAGAGGTAGGGAGGGGAGTATGGGTTCATTTGGCTTCGCATTATGCAAGGTGAAACCGT
TTGTTTTCCCTCTCCATTTTCCCTAACTAAATGAAAAGGACACATTCTGAAATCCCTTTTGTTGGAGAATAAGTCAGTCTGAGGGGAAAT
GGGAGGCCAGAGATGAGAACCCTTTGAAAAGATTGTAAAATACTGATTTTCATTCTTTCAAGCTTATTTGTAAATACCTATTTGAATGCT
GTGTATTTGTACAGGAATTTGAGCAAAAAATGTATAGAGTGTGATGTCCAATTGGTATTCAGCACTATAAATGTGTTTTTAACCTCCCGC
ATTCTGTGCTTATTTAAAACAAGGAAACTTCTAACCATTTCTTTTGTGTATTCATGTTTAAAGAAAAAAAGTGATTTAAAAATGATCTTA
CCTGTACCAGAAAAGCAAAGTTAAAGGAAACAAAATTTGTACCATTGTCCCAAGAGGTATTTTACTGTATATATTGTGGTAGCATGTTCA
AAATCCAACAAGTAATGTGAATTTTAGATGTAAATATCTGCCACTTGATTTTTTTTCCCCCTTTCCCCACTTCCTTGACTGCTGTGATGT

>91085_91085_1_TKT-DOCK3_TKT_chr3_53289852_ENST00000423516_DOCK3_chr3_50927457_ENST00000266037_length(amino acids)=1967AA_BP=
MKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWG
NEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFFLSLKSFTYNTIGEDTDVFFSLYDMR
EGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPPHLHYRRPYGCAVLSILDVLQSLTE
VKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRND
LYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCS
TKDKGEKKLFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKL
TQNVDLLALLKWKAFPDRIMDVLGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKH
FAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLF
TQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKEL
LICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHFQHL
LDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEI
ITSAKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKL
DSMVSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINK
EEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYES
LYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQC
DAQYLQIYAVTPIPDYVDVLQMDRVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVE
VSPLENAIQVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYINKHPGDAEKITQLKELMQEQVHVL
GVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPESIKMTHRHSPMNLMGTGRHSSSS
LSSHASSEAGNMVMLGDGSMGDAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKY
RHAREMMLLLPTYRDRPSSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPNLSVAEKGHYSLHFDAFHHPLGDTPPALPARTLRKSP
LHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPC

--------------------------------------------------------------
>91085_91085_2_TKT-DOCK3_TKT_chr3_53289852_ENST00000423525_DOCK3_chr3_50927457_ENST00000266037_length(transcript)=8735nt_BP=165nt
GGGAGCAGCCGCTATCTCTGTGTGTCCGCGTGTGCGCCCGGTCCCCGCCTGCCGCACCATGGAGAGCTACCACAAGCCTGACCAGCAGAA
GCTGCAGGCCTTGAAGGACACGGCCAACCGCCTACGTATCAGCTCCATCCAGGCCACCACTGCGGCGGGCTCTGGGGGATCTTTCCTGCA
AATTACATTCACTTGAAAAAGGCAATTGTCAGTAATAGGGGGCAGTATGAAACTGTGGTTCCACTTGAAGATTCTATTGTGACTGAGGTT
ACAGCAACTCTACAAGAATGGGCAAGTTTGTGGAAACAGTTGTATGTGAAACACAAAGTAGATCTTTTCTACAAACTACGCCATGTGATG
AATGAACTTATTGACCTGCGAAGGCAGCTACTGTCTGGTCACCTGACTCAGGATCAGGTGCGGGAGGTTAAGCGGCACATCACCGTGCGC
CTGGACTGGGGTAATGAACATTTGGGCCTGGACCTGGTGCCTCGGAAGGACTTTGAAGTAGTGGACTCGGACCAGATTAGTGTCTCAGAT
CTCTATAAGATGCATTTATCTAGCCGGCAGAGTGTACAGCAAAGCACATCCCAGGTAGATACAATGCGCCCACGTCATGGGGAAACATGT
CGGATGCCAGTGCCACATCACTTCTTCCTCAGCCTGAAGAGTTTCACTTACAATACTATTGGGGAAGATACCGATGTCTTCTTTTCCTTA
TATGACATGAGGGAAGGCAAGCAGATCAGTGAGCGGTTTCTGGTAAGACTGAACAAGAATGGTGGGCCGAGGAACCCAGAGAAGATAGAA
CGAATGTGTGCCCTTTTTACAGATCTGAGCAGCAAAGATATGAAGAGAGATTTGTATATCGTTGCCCATGTGATCCGAATAGGCCGGATG
CTCCTGAACGACTCAAAGAAAGGTCCTCCTCACCTGCACTACAGGCGACCATATGGCTGTGCGGTCCTAAGCATCTTGGATGTCCTACAG
TCACTCACAGAAGTAAAGGAAGAAAAGGATTTTGTTCTTAAGGTTTACACGTGCAACAACGAGAGTGAGTGGTCCCAGATCCACGAGAAC
ATCATCCGAAAGTCCAGTGCCAAGTACTCTGCCCCCAGCGCCAGCCATGGTCTTATCATTTCTCTGCAGCTTCTTCGTGGAGACATGGAA
CAGATTCGGAGAGAAAATCCCATGATATTTAATAGGGGATTGGCAATTACAAGAAAATTGGGATTTCCTGATGTCATTATGCCAGGTGAT
ATCCGCAATGACCTGTACCTAACCCTGGAGAAGGGGGATTTCGAGAGAGGAGGAAAGAGTGTACAAAAGAATATTGAAGTGACCATGTAT
GTGCTTTATGCAGATGGAGAAATCTTGAAGGATTGCATCAGCTTGGGTTCAGGAGAGCCAAATAGGAGTTCCTACCACTCCTTTGTCCTC
TACCACAGTAATAGTCCTCGCTGGGGAGAAATTATCAAATTGCCTATCCCCATTGACCGGTTCCGGGGCTCCCACCTGCGCTTTGAGTTC
AGACATTGTTCCACAAAGGACAAAGGGGAAAAGAAACTCTTTGGCTTTGCATTCTCAACCCTGATGCGTGATGATGGCACCACCCTCTCA
GATGATATTCACGAGCTTTATGTGTACAAGTGTGATGAGAATAGCACGTTTAATAACCATGCTCTGTACCTGGGCCTGCCCTGCTGCAAA
GAGGACTACAATGGCTGCCCTAATATTCCTTCTAGCCTCATCTTCCAGCGCAGCACCAAAGAGTCTTTCTTCATCTCCACTCAGCTCTCC
TCTACCAAACTCACCCAGAATGTGGACCTCCTAGCTCTGCTGAAGTGGAAAGCCTTCCCCGACCGGATCATGGATGTACTAGGGCGGCTG
CGGCATGTCAGTGGGGAGGAAATTGTTAAGTTTCTGCAGGACATCTTAGATACACTCTTTGTGATTTTGGATGATAATACAGAGAAGTAC
GGCCTGTTGGTTTTTCAGTCTCTGGTGTTCATCATCAACCTGCTCCGAGACATCAAGTATTTTCACTTTCGACCTGTGATGGACACGTAT
ATCCAGAAGCACTTTGCTGGAGCTCTGGCATACAAGGAGCTCATCCGCTGTTTGAAGTGGTATATGGACTGCTCAGCAGAACTGATTCGA
CAGGACCACATTCAAGAAGCTATGCGGGCCTTGGAGTACCTTTTCAAGTTCATTGTACAGTCACGGATCCTGTACTCACGAGCCACTTGT
GGAATGGAAGAGGAACAATTCAGATCCAGTATCCAAGAACTTTTCCAGTCCATCCGGTTTGTGCTCAGTCTGGACAGCCGAAACTCAGAA
ACACTCCTTTTTACTCAGGCTGCACTCCTCAATTCTTTCCCAACCATCTTTGATGAGCTTCTGCAAATGTTCACCGTGCAAGAGGTGGCA
GAGTTTGTGAGAGGGACACTGGGGAGCATGCCCAGCACTGTGCACATTGGGCAGTCAATGGACGTGGTCAAGCTGCAGTCCATTGCCAGG
ACAGTGGATAGCCGCCTGTTTTCTTTCTCAGAATCCCGCCGCATCCTGCTTCCTGTGGTTCTCCATCACATTCACCTTCACCTGAGGCAG
CAGAAAGAGCTGCTAATTTGCTCAGGGATTCTTGGCAGCATCTTCTCCATCGTCAAGACCAGCTCTCTGGAGGCAGATGTCATGGAGGAA
GTAGAGATGATGGTGGAGAGCCTCCTGGACGTGCTCTTGCAGACTCTGCTCACCATCATGAGCAAATCGCACGCTCAGGAGGCGGTAAGA
GGGCAGCGGTGCCCGCAGTGCACAGCCGAGATCACTGGCGAGTATGTGTCCTGCCTTCTCTCACTGCTCCGCCAGATGTGTGACACCCAT
TTCCAGCACCTCCTGGACAACTTCCAGAGCAAAGATGAACTCAAGGAATTTCTGCTGAAGATTTTTTGCGTGTTCCGGAACCTGATGAAG
ATGAGTGTCTTCCCTCGGGACTGGATGGTAATGAGACTGCTCACAAGCAATATTATAGTCACTACTGTCCAGTACCTGTCCTCTGCACTG
CACAAGAATTTCACAGAGACTGACTTTGACTTTAAGGTGTGGAATTCTTACTTTAGCCTGGCAGTTCTATTCATAAATCAGCCAAGCCTT
CAGCTAGAAATTATCACCTCAGCCAAAAGGAAGAAGATTCTAGATAAGTATGGGGACATGCGTGTAATGATGGCCTATGAACTGTTCAGC
ATGTGGCAGAATTTGGGTGAACATAAGATCCACTTTATTCCGGGAATGATTGGTCCTTTTCTGGGTGTGACACTGGTCCCACAGCCAGAA
GTACGGAATATCATGATTCCCATCTTTCATGACATGATGGACTGGGAGCAGAGAAAAAATGGCAACTTCAAACAGGTGGAGGCCGAGTTG
ATTGACAAGCTGGACAGCATGGTGTCAGAAGGGAAAGGTGACGAGAGCTACAGGGAGCTCTTCAGCCTACTAACCCAGCTGTTTGGGCCC
TACCCCAGCCTGCTGGAGAAGGTTGAACAAGAAACATGGCGCGAGACCGGCATTTCCTTTGTGACCTCAGTCACCCGCCTCATGGAACGT
CTTCTTGACTACAGGGACTGCATGAAAGGAGAGGAAACAGAGAATAAGAAGATAGGCTGCACTGTTAACCTGATGAATTTTTACAAATCT
GAGATTAACAAGGAAGAAATGTATATCCGCTACATCCATAAGCTTTGTGACATGCACTTGCAGGCCGAAAACTACACAGAGGCCGCATTT
ACCCTGCTCCTTTACTGTGAGCTGCTGCAGTGGGAGGACCGGCCACTACGGGAATTCCTCCACTACCCATCGCAGACAGAGTGGCAGCGG
AAGGAGGGACTGTGCCGGAAGATCATTCACTACTTCAACAAAGGCAAGAGCTGGGAGTTTGGGATCCCACTGTGCAGGGAGCTGGCGTGT
CAGTACGAGAGCCTCTATGATTACCAGAGCCTCAGCTGGATTCGGAAAATGGAGGCCAGCTACTATGACAACATTATGGAGCAGCAACGC
CTGGAGCCTGAGTTCTTTCGGGTCGGCTTCTATGGCAGGAAGTTTCCTTTCTTTCTTCGGAACAAAGAATACGTGTGCCGTGGCCATGAC
TACGAGAGGCTGGAGGCCTTCCAGCAGAGGATGCTCAGTGAGTTTCCGCAGGCTGTCGCCATGCAGCACCCCAACCATCCTGATGACGCC
ATCCTACAGTGCGATGCCCAGTACTTGCAGATCTATGCAGTGACGCCCATTCCAGATTATGTGGATGTTCTGCAGATGGATAGGGTACCA
GATCGAGTCAAGAGCTTCTATCGCGTCAACAATGTGAGGAAGTTCCGGTATGACAGGCCTTTTCACAAAGGCCCCAAGGACAAGGAGAAT
GAATTCAAGAGCCTGTGGATTGAACGTACCACACTGACCCTGACCCACAGCTTGCCTGGCATCTCTCGGTGGTTTGAAGTGGAGAGGAGG
GAACTGGTGGAGGTGAGCCCTCTGGAGAATGCCATCCAAGTGGTTGAGAATAAGAACCAGGAGCTACGCTCCCTGATCAGCCAGTATCAA
CACAAGCAGGTGCATGGCAACATTAACCTGCTAAGCATGTGCCTGAATGGTGTCATTGATGCAGCTGTCAATGGAGGCATTGCACGCTAT
CAGGAGGCCTTCTTTGATAAAGATTACATCAACAAGCACCCAGGAGATGCTGAGAAGATCACCCAGCTCAAGGAGCTTATGCAGGAGCAG
GTTCATGTCCTTGGAGTTGGGCTAGCAGTTCATGAGAAGTTTGTGCACCCAGAAATGCGGCCTCTGCATAAGAAGCTAATTGATCAGTTC
CAGATGATGCGGGCCAGTCTCTACCATGAGTTTCCAGGTTTGGATAAGCTAAGTCCTGCATGTTCAGGCACCAGCACCCCACGGGGAAAT
GTTCTGGCATCCCATAGCCCCATGAGTCCGGAGAGCATCAAGATGACCCACCGGCACAGCCCCATGAACTTGATGGGCACAGGCCGCCAT
TCATCATCCTCTCTCTCCTCACATGCGTCTAGTGAAGCAGGAAACATGGTGATGCTGGGTGACGGCTCCATGGGTGATGCTCCTGAGGAC
CTGTACCACCACATGCAGCTCGCGTATCCCAACCCCAGGTACCAAGGCTCAGTCACCAACGTCTCTGTTCTGTCCTCGTCCCAGGCAAGC
CCTTCTTCCTCCAGCCTGAGTTCCACTCACTCAGCACCATCCCAGATGATTACCTCTGCCCCTTCCAGTGCCCGAGGCTCTCCCTCTCTG
CCAGATAAGTACCGCCATGCCCGTGAAATGATGTTGTTGCTGCCCACATACCGGGACCGCCCAAGCAGTGCCATGTATCCAGCAGCCATC
CTGGAGAACGGACAGCCGCCGAATTTCCAGCGAGCCCTGTTCCAGCAAGTGGTCGGAGCCTGCAAACCCTGCAGTGATCCCAATCTGTCT
GTGGCTGAAAAAGGTCATTACTCCCTACACTTTGACGCCTTCCACCACCCTCTGGGTGATACCCCCCCAGCCCTCCCTGCCCGGACCCTG
CGCAAGTCTCCTCTCCACCCTATCCCAGCCTCCCCCACAAGCCCCCAGTCAGGTCTGGACGGCAGCAACTCTACGCTGTCCGGCAGTGCC
AGCAGCGGCGTGTCCTCCTTGAGTGAGAGTAACTTTGGGCACTCCTCGGAGGCCCCACCTCGCACTGACACCATGGACTCCATGCCAAGT
CAGGCCTGGAATGCTGACGAAGATCTTGAGCCACCCTACCTCCCTGTCCACTACAGCCTCTCTGAGTCTGCCGTCCTGGACTCCATCAAG
GCCCAGCCATGCCGAAGCCACTCAGCCCCAGGGTGCGTCATCCCTCAGGACCCCATGGACCCGCCTGCGCTGCCGCCCAAGCCCTACCAC
CCCCGCCTGCCGGCCCTGGAGCACGATGAGGGGGTGCTGCTGCGTGAAGAGACTGAGAGGCCTCGAGGCCTGCACCGCAAGGCTCCATTG
CCTCCTGGGAGCGCTAAGGAGGAGCAGGCCCGCATGGCCTGGGAGCACGGCCGAGGGGAGCAGTGAGGGGCAACGAGGCGGCTGGGATGC
CGCCCTCAGTAAGCAGCTTGCCAATCACTCCAGGTCTGAAAAGCAAGTCCCCCAGCCCCACCCCAGGGAGCCAGAGAGGCTTGCACTCAG
GAGAGAACCACCCCCAAGTCTCCGTTCTACTGCCGTGAACTCATGTGTTGCCATGTACAGAGGCCACAGCAGCATGAAGGGTTGTGGCTT
CCCTTTTTATTTTTTTACATTTCCATTTCTATGGGTTTTCCTTTCTTTCCTTTATGCAGTAGATGCTTTCTTCCTCCTGCAGTTCTGGAC
CATGTGGAGCTACATGGAGAAATTGCACAGACAGAATCACTTTGCCACACTGCAGGGCCCAGGAGTGGGAGCCCAGGCCCTCCCTCCAGG
GTAGAGATGCACCGAATGGAAATTGCACTAAGGACCTCTTCCTTTGCTGTATGGACAGAAGAGTTCATGGTTGCATTCAGGGATTGCAAG
GACCATATAGACATGTCACAGGTGGAAAAAGGGCCACAAGCCGTTTTGCACAAATGCCTGCCCACCTGCCCCTCTTCCATCCAGGAGTGT
GCTACTGAGGGGCTGGCTGGACCAACCTGCTGGCTCAGGCATGTGACTGGCCTAACTGCATGCCCAGGGCACTGCCAGGGTTCAATGGGC
CAGCCGTCTCCTACTCCACCTTGGATTTTTCTCTCCATCACATCATTTCTGACCATTTGCTCCCTTCCATTCTTGAAACACCTCATGCCC
CACAGGAGCCCCAGTGGTGACTGGATCTGCAAGGGTTATCTCCCGCCCTCTGGGGTTTGAGTGGAGGTATGGAGCCAGAGAGGCTATCCT
AGCTACCTTCCTCCTAGGGGGAGCTGGTCCCCTTCCTATGTGGTAGAGAGACTGGTGTAAGAGTGTGGGGTGTGGCAGGCGCCGGAAATC
CTCAAAGCTTTCAGAAGCATCCAGAATGCCTACCATCAGCTCCTGAATCAGGGATTTTCAGCACTACCTCTGAGCCATGGGGTTGGCTGC
CCAGCCAGGCTTCCAGGCCCTGAGGACATGTGGTCAGGTTCAGCAGGCTCCTGGGTAAAGAGGGTGGGAGGGGGCTTCTCCTTTTGGAAG
CAGATAGCCATGCAGGTAGAATTGTCATCTCCCAAGTGGCCACATACAGCAACCCACTCCAGGCCATGGGGACCACCACTCAGGGTTCGG
GGCTGGCAGGAGGGTAGTTTCTCCAGTCTCCCCAGTCTGTTGGTGTCTTTATAGGAAACTATAAAGCAGAGCAGTGGTGTCTTTAGAGGA
AACTCATTCAAGTCAGGGCACTGATTTTCCTCTCAGTTTATTATTTGGGGGGATAGGGTCAGGTGGGTATAGTAGTACTTTACCAGGGTG
CTTTTAAGTTACTTTAAAAAAAGCCTACAAAATATTTTTTTTCTTTTATTTGCTCGAGTTCACATTAATGATGGTCACAAGGCTGCCTTG
TTGGGCAGGCGTATTGCCCCCAGTTCCTCTTCTGCTGGCCTGTATGACCTCCACAGCCAGGCCCTGGGCCCAAGCCCCTTGTCCCTTCTC
CACTGCCCCTCTTTCCAGACAGTAAAGGCCATGGTCAGTGTGTTTTTCTCTTGTAAACAAACCCCAGCTTGTTTAACAGAAATGCTAATA
ACCTACTGGGAAAGATGGAGGTCTAAATTACCTCCAGGGTTTTTCTGGGGGTTTATCACCAGTGTGGGTCCCTTCTGATACCACCAGGTT
CACTCCAGGCAGAGTGGGGCGGAAGGCTGCTGAGGATATGGGTCAGTTACAGCAGCCCTCACCTCAAAGGGCTGGCCTGCTTCTCAGCCT
ACATTCATTTGCAAGCTTCAATCTCTGGACCATCTGGTGTTCACAGGTGTTAGAGGGTTAGGGGTTAGGGGCTAGTTTTGGATTTGATTC
ATAGGTAGGAGGGCTTAGATTTTAAGGCACTTCTGAAAGTCAATCCCTGGACAAGGCAGTCATCACATAAGAACAGCTACCTTCTCCACT
TGGTGGCACAAGAGGTAGGGAGGGGAGTATGGGTTCATTTGGCTTCGCATTATGCAAGGTGAAACCGTTTGTTTTCCCTCTCCATTTTCC
CTAACTAAATGAAAAGGACACATTCTGAAATCCCTTTTGTTGGAGAATAAGTCAGTCTGAGGGGAAATGGGAGGCCAGAGATGAGAACCC
TTTGAAAAGATTGTAAAATACTGATTTTCATTCTTTCAAGCTTATTTGTAAATACCTATTTGAATGCTGTGTATTTGTACAGGAATTTGA
GCAAAAAATGTATAGAGTGTGATGTCCAATTGGTATTCAGCACTATAAATGTGTTTTTAACCTCCCGCATTCTGTGCTTATTTAAAACAA
GGAAACTTCTAACCATTTCTTTTGTGTATTCATGTTTAAAGAAAAAAAGTGATTTAAAAATGATCTTACCTGTACCAGAAAAGCAAAGTT
AAAGGAAACAAAATTTGTACCATTGTCCCAAGAGGTATTTTACTGTATATATTGTGGTAGCATGTTCAAAATCCAACAAGTAATGTGAAT
TTTAGATGTAAATATCTGCCACTTGATTTTTTTTCCCCCTTTCCCCACTTCCTTGACTGCTGTGATGTGAATTAAAGATAAATACGTGAT

>91085_91085_2_TKT-DOCK3_TKT_chr3_53289852_ENST00000423525_DOCK3_chr3_50927457_ENST00000266037_length(amino acids)=1967AA_BP=
MKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWG
NEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFFLSLKSFTYNTIGEDTDVFFSLYDMR
EGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPPHLHYRRPYGCAVLSILDVLQSLTE
VKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRND
LYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCS
TKDKGEKKLFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKL
TQNVDLLALLKWKAFPDRIMDVLGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKH
FAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLF
TQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKEL
LICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHFQHL
LDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEI
ITSAKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKL
DSMVSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINK
EEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYES
LYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQC
DAQYLQIYAVTPIPDYVDVLQMDRVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVE
VSPLENAIQVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYINKHPGDAEKITQLKELMQEQVHVL
GVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPESIKMTHRHSPMNLMGTGRHSSSS
LSSHASSEAGNMVMLGDGSMGDAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKY
RHAREMMLLLPTYRDRPSSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPNLSVAEKGHYSLHFDAFHHPLGDTPPALPARTLRKSP
LHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPC

--------------------------------------------------------------
>91085_91085_3_TKT-DOCK3_TKT_chr3_53289852_ENST00000462138_DOCK3_chr3_50927457_ENST00000266037_length(transcript)=8766nt_BP=196nt
GCGCCCGGCCTCGGCAGCCGCCTGTCGCCGCGGGAGCAGCCGCTATCTCTGTGTGTCCGCGTGTGCGCCCGGTCCCCGCCTGCCGCACCA
TGGAGAGCTACCACAAGCCTGACCAGCAGAAGCTGCAGGCCTTGAAGGACACGGCCAACCGCCTACGTATCAGCTCCATCCAGGCCACCA
CTGCGGCGGGCTCTGGGGGATCTTTCCTGCAAATTACATTCACTTGAAAAAGGCAATTGTCAGTAATAGGGGGCAGTATGAAACTGTGGT
TCCACTTGAAGATTCTATTGTGACTGAGGTTACAGCAACTCTACAAGAATGGGCAAGTTTGTGGAAACAGTTGTATGTGAAACACAAAGT
AGATCTTTTCTACAAACTACGCCATGTGATGAATGAACTTATTGACCTGCGAAGGCAGCTACTGTCTGGTCACCTGACTCAGGATCAGGT
GCGGGAGGTTAAGCGGCACATCACCGTGCGCCTGGACTGGGGTAATGAACATTTGGGCCTGGACCTGGTGCCTCGGAAGGACTTTGAAGT
AGTGGACTCGGACCAGATTAGTGTCTCAGATCTCTATAAGATGCATTTATCTAGCCGGCAGAGTGTACAGCAAAGCACATCCCAGGTAGA
TACAATGCGCCCACGTCATGGGGAAACATGTCGGATGCCAGTGCCACATCACTTCTTCCTCAGCCTGAAGAGTTTCACTTACAATACTAT
TGGGGAAGATACCGATGTCTTCTTTTCCTTATATGACATGAGGGAAGGCAAGCAGATCAGTGAGCGGTTTCTGGTAAGACTGAACAAGAA
TGGTGGGCCGAGGAACCCAGAGAAGATAGAACGAATGTGTGCCCTTTTTACAGATCTGAGCAGCAAAGATATGAAGAGAGATTTGTATAT
CGTTGCCCATGTGATCCGAATAGGCCGGATGCTCCTGAACGACTCAAAGAAAGGTCCTCCTCACCTGCACTACAGGCGACCATATGGCTG
TGCGGTCCTAAGCATCTTGGATGTCCTACAGTCACTCACAGAAGTAAAGGAAGAAAAGGATTTTGTTCTTAAGGTTTACACGTGCAACAA
CGAGAGTGAGTGGTCCCAGATCCACGAGAACATCATCCGAAAGTCCAGTGCCAAGTACTCTGCCCCCAGCGCCAGCCATGGTCTTATCAT
TTCTCTGCAGCTTCTTCGTGGAGACATGGAACAGATTCGGAGAGAAAATCCCATGATATTTAATAGGGGATTGGCAATTACAAGAAAATT
GGGATTTCCTGATGTCATTATGCCAGGTGATATCCGCAATGACCTGTACCTAACCCTGGAGAAGGGGGATTTCGAGAGAGGAGGAAAGAG
TGTACAAAAGAATATTGAAGTGACCATGTATGTGCTTTATGCAGATGGAGAAATCTTGAAGGATTGCATCAGCTTGGGTTCAGGAGAGCC
AAATAGGAGTTCCTACCACTCCTTTGTCCTCTACCACAGTAATAGTCCTCGCTGGGGAGAAATTATCAAATTGCCTATCCCCATTGACCG
GTTCCGGGGCTCCCACCTGCGCTTTGAGTTCAGACATTGTTCCACAAAGGACAAAGGGGAAAAGAAACTCTTTGGCTTTGCATTCTCAAC
CCTGATGCGTGATGATGGCACCACCCTCTCAGATGATATTCACGAGCTTTATGTGTACAAGTGTGATGAGAATAGCACGTTTAATAACCA
TGCTCTGTACCTGGGCCTGCCCTGCTGCAAAGAGGACTACAATGGCTGCCCTAATATTCCTTCTAGCCTCATCTTCCAGCGCAGCACCAA
AGAGTCTTTCTTCATCTCCACTCAGCTCTCCTCTACCAAACTCACCCAGAATGTGGACCTCCTAGCTCTGCTGAAGTGGAAAGCCTTCCC
CGACCGGATCATGGATGTACTAGGGCGGCTGCGGCATGTCAGTGGGGAGGAAATTGTTAAGTTTCTGCAGGACATCTTAGATACACTCTT
TGTGATTTTGGATGATAATACAGAGAAGTACGGCCTGTTGGTTTTTCAGTCTCTGGTGTTCATCATCAACCTGCTCCGAGACATCAAGTA
TTTTCACTTTCGACCTGTGATGGACACGTATATCCAGAAGCACTTTGCTGGAGCTCTGGCATACAAGGAGCTCATCCGCTGTTTGAAGTG
GTATATGGACTGCTCAGCAGAACTGATTCGACAGGACCACATTCAAGAAGCTATGCGGGCCTTGGAGTACCTTTTCAAGTTCATTGTACA
GTCACGGATCCTGTACTCACGAGCCACTTGTGGAATGGAAGAGGAACAATTCAGATCCAGTATCCAAGAACTTTTCCAGTCCATCCGGTT
TGTGCTCAGTCTGGACAGCCGAAACTCAGAAACACTCCTTTTTACTCAGGCTGCACTCCTCAATTCTTTCCCAACCATCTTTGATGAGCT
TCTGCAAATGTTCACCGTGCAAGAGGTGGCAGAGTTTGTGAGAGGGACACTGGGGAGCATGCCCAGCACTGTGCACATTGGGCAGTCAAT
GGACGTGGTCAAGCTGCAGTCCATTGCCAGGACAGTGGATAGCCGCCTGTTTTCTTTCTCAGAATCCCGCCGCATCCTGCTTCCTGTGGT
TCTCCATCACATTCACCTTCACCTGAGGCAGCAGAAAGAGCTGCTAATTTGCTCAGGGATTCTTGGCAGCATCTTCTCCATCGTCAAGAC
CAGCTCTCTGGAGGCAGATGTCATGGAGGAAGTAGAGATGATGGTGGAGAGCCTCCTGGACGTGCTCTTGCAGACTCTGCTCACCATCAT
GAGCAAATCGCACGCTCAGGAGGCGGTAAGAGGGCAGCGGTGCCCGCAGTGCACAGCCGAGATCACTGGCGAGTATGTGTCCTGCCTTCT
CTCACTGCTCCGCCAGATGTGTGACACCCATTTCCAGCACCTCCTGGACAACTTCCAGAGCAAAGATGAACTCAAGGAATTTCTGCTGAA
GATTTTTTGCGTGTTCCGGAACCTGATGAAGATGAGTGTCTTCCCTCGGGACTGGATGGTAATGAGACTGCTCACAAGCAATATTATAGT
CACTACTGTCCAGTACCTGTCCTCTGCACTGCACAAGAATTTCACAGAGACTGACTTTGACTTTAAGGTGTGGAATTCTTACTTTAGCCT
GGCAGTTCTATTCATAAATCAGCCAAGCCTTCAGCTAGAAATTATCACCTCAGCCAAAAGGAAGAAGATTCTAGATAAGTATGGGGACAT
GCGTGTAATGATGGCCTATGAACTGTTCAGCATGTGGCAGAATTTGGGTGAACATAAGATCCACTTTATTCCGGGAATGATTGGTCCTTT
TCTGGGTGTGACACTGGTCCCACAGCCAGAAGTACGGAATATCATGATTCCCATCTTTCATGACATGATGGACTGGGAGCAGAGAAAAAA
TGGCAACTTCAAACAGGTGGAGGCCGAGTTGATTGACAAGCTGGACAGCATGGTGTCAGAAGGGAAAGGTGACGAGAGCTACAGGGAGCT
CTTCAGCCTACTAACCCAGCTGTTTGGGCCCTACCCCAGCCTGCTGGAGAAGGTTGAACAAGAAACATGGCGCGAGACCGGCATTTCCTT
TGTGACCTCAGTCACCCGCCTCATGGAACGTCTTCTTGACTACAGGGACTGCATGAAAGGAGAGGAAACAGAGAATAAGAAGATAGGCTG
CACTGTTAACCTGATGAATTTTTACAAATCTGAGATTAACAAGGAAGAAATGTATATCCGCTACATCCATAAGCTTTGTGACATGCACTT
GCAGGCCGAAAACTACACAGAGGCCGCATTTACCCTGCTCCTTTACTGTGAGCTGCTGCAGTGGGAGGACCGGCCACTACGGGAATTCCT
CCACTACCCATCGCAGACAGAGTGGCAGCGGAAGGAGGGACTGTGCCGGAAGATCATTCACTACTTCAACAAAGGCAAGAGCTGGGAGTT
TGGGATCCCACTGTGCAGGGAGCTGGCGTGTCAGTACGAGAGCCTCTATGATTACCAGAGCCTCAGCTGGATTCGGAAAATGGAGGCCAG
CTACTATGACAACATTATGGAGCAGCAACGCCTGGAGCCTGAGTTCTTTCGGGTCGGCTTCTATGGCAGGAAGTTTCCTTTCTTTCTTCG
GAACAAAGAATACGTGTGCCGTGGCCATGACTACGAGAGGCTGGAGGCCTTCCAGCAGAGGATGCTCAGTGAGTTTCCGCAGGCTGTCGC
CATGCAGCACCCCAACCATCCTGATGACGCCATCCTACAGTGCGATGCCCAGTACTTGCAGATCTATGCAGTGACGCCCATTCCAGATTA
TGTGGATGTTCTGCAGATGGATAGGGTACCAGATCGAGTCAAGAGCTTCTATCGCGTCAACAATGTGAGGAAGTTCCGGTATGACAGGCC
TTTTCACAAAGGCCCCAAGGACAAGGAGAATGAATTCAAGAGCCTGTGGATTGAACGTACCACACTGACCCTGACCCACAGCTTGCCTGG
CATCTCTCGGTGGTTTGAAGTGGAGAGGAGGGAACTGGTGGAGGTGAGCCCTCTGGAGAATGCCATCCAAGTGGTTGAGAATAAGAACCA
GGAGCTACGCTCCCTGATCAGCCAGTATCAACACAAGCAGGTGCATGGCAACATTAACCTGCTAAGCATGTGCCTGAATGGTGTCATTGA
TGCAGCTGTCAATGGAGGCATTGCACGCTATCAGGAGGCCTTCTTTGATAAAGATTACATCAACAAGCACCCAGGAGATGCTGAGAAGAT
CACCCAGCTCAAGGAGCTTATGCAGGAGCAGGTTCATGTCCTTGGAGTTGGGCTAGCAGTTCATGAGAAGTTTGTGCACCCAGAAATGCG
GCCTCTGCATAAGAAGCTAATTGATCAGTTCCAGATGATGCGGGCCAGTCTCTACCATGAGTTTCCAGGTTTGGATAAGCTAAGTCCTGC
ATGTTCAGGCACCAGCACCCCACGGGGAAATGTTCTGGCATCCCATAGCCCCATGAGTCCGGAGAGCATCAAGATGACCCACCGGCACAG
CCCCATGAACTTGATGGGCACAGGCCGCCATTCATCATCCTCTCTCTCCTCACATGCGTCTAGTGAAGCAGGAAACATGGTGATGCTGGG
TGACGGCTCCATGGGTGATGCTCCTGAGGACCTGTACCACCACATGCAGCTCGCGTATCCCAACCCCAGGTACCAAGGCTCAGTCACCAA
CGTCTCTGTTCTGTCCTCGTCCCAGGCAAGCCCTTCTTCCTCCAGCCTGAGTTCCACTCACTCAGCACCATCCCAGATGATTACCTCTGC
CCCTTCCAGTGCCCGAGGCTCTCCCTCTCTGCCAGATAAGTACCGCCATGCCCGTGAAATGATGTTGTTGCTGCCCACATACCGGGACCG
CCCAAGCAGTGCCATGTATCCAGCAGCCATCCTGGAGAACGGACAGCCGCCGAATTTCCAGCGAGCCCTGTTCCAGCAAGTGGTCGGAGC
CTGCAAACCCTGCAGTGATCCCAATCTGTCTGTGGCTGAAAAAGGTCATTACTCCCTACACTTTGACGCCTTCCACCACCCTCTGGGTGA
TACCCCCCCAGCCCTCCCTGCCCGGACCCTGCGCAAGTCTCCTCTCCACCCTATCCCAGCCTCCCCCACAAGCCCCCAGTCAGGTCTGGA
CGGCAGCAACTCTACGCTGTCCGGCAGTGCCAGCAGCGGCGTGTCCTCCTTGAGTGAGAGTAACTTTGGGCACTCCTCGGAGGCCCCACC
TCGCACTGACACCATGGACTCCATGCCAAGTCAGGCCTGGAATGCTGACGAAGATCTTGAGCCACCCTACCTCCCTGTCCACTACAGCCT
CTCTGAGTCTGCCGTCCTGGACTCCATCAAGGCCCAGCCATGCCGAAGCCACTCAGCCCCAGGGTGCGTCATCCCTCAGGACCCCATGGA
CCCGCCTGCGCTGCCGCCCAAGCCCTACCACCCCCGCCTGCCGGCCCTGGAGCACGATGAGGGGGTGCTGCTGCGTGAAGAGACTGAGAG
GCCTCGAGGCCTGCACCGCAAGGCTCCATTGCCTCCTGGGAGCGCTAAGGAGGAGCAGGCCCGCATGGCCTGGGAGCACGGCCGAGGGGA
GCAGTGAGGGGCAACGAGGCGGCTGGGATGCCGCCCTCAGTAAGCAGCTTGCCAATCACTCCAGGTCTGAAAAGCAAGTCCCCCAGCCCC
ACCCCAGGGAGCCAGAGAGGCTTGCACTCAGGAGAGAACCACCCCCAAGTCTCCGTTCTACTGCCGTGAACTCATGTGTTGCCATGTACA
GAGGCCACAGCAGCATGAAGGGTTGTGGCTTCCCTTTTTATTTTTTTACATTTCCATTTCTATGGGTTTTCCTTTCTTTCCTTTATGCAG
TAGATGCTTTCTTCCTCCTGCAGTTCTGGACCATGTGGAGCTACATGGAGAAATTGCACAGACAGAATCACTTTGCCACACTGCAGGGCC
CAGGAGTGGGAGCCCAGGCCCTCCCTCCAGGGTAGAGATGCACCGAATGGAAATTGCACTAAGGACCTCTTCCTTTGCTGTATGGACAGA
AGAGTTCATGGTTGCATTCAGGGATTGCAAGGACCATATAGACATGTCACAGGTGGAAAAAGGGCCACAAGCCGTTTTGCACAAATGCCT
GCCCACCTGCCCCTCTTCCATCCAGGAGTGTGCTACTGAGGGGCTGGCTGGACCAACCTGCTGGCTCAGGCATGTGACTGGCCTAACTGC
ATGCCCAGGGCACTGCCAGGGTTCAATGGGCCAGCCGTCTCCTACTCCACCTTGGATTTTTCTCTCCATCACATCATTTCTGACCATTTG
CTCCCTTCCATTCTTGAAACACCTCATGCCCCACAGGAGCCCCAGTGGTGACTGGATCTGCAAGGGTTATCTCCCGCCCTCTGGGGTTTG
AGTGGAGGTATGGAGCCAGAGAGGCTATCCTAGCTACCTTCCTCCTAGGGGGAGCTGGTCCCCTTCCTATGTGGTAGAGAGACTGGTGTA
AGAGTGTGGGGTGTGGCAGGCGCCGGAAATCCTCAAAGCTTTCAGAAGCATCCAGAATGCCTACCATCAGCTCCTGAATCAGGGATTTTC
AGCACTACCTCTGAGCCATGGGGTTGGCTGCCCAGCCAGGCTTCCAGGCCCTGAGGACATGTGGTCAGGTTCAGCAGGCTCCTGGGTAAA
GAGGGTGGGAGGGGGCTTCTCCTTTTGGAAGCAGATAGCCATGCAGGTAGAATTGTCATCTCCCAAGTGGCCACATACAGCAACCCACTC
CAGGCCATGGGGACCACCACTCAGGGTTCGGGGCTGGCAGGAGGGTAGTTTCTCCAGTCTCCCCAGTCTGTTGGTGTCTTTATAGGAAAC
TATAAAGCAGAGCAGTGGTGTCTTTAGAGGAAACTCATTCAAGTCAGGGCACTGATTTTCCTCTCAGTTTATTATTTGGGGGGATAGGGT
CAGGTGGGTATAGTAGTACTTTACCAGGGTGCTTTTAAGTTACTTTAAAAAAAGCCTACAAAATATTTTTTTTCTTTTATTTGCTCGAGT
TCACATTAATGATGGTCACAAGGCTGCCTTGTTGGGCAGGCGTATTGCCCCCAGTTCCTCTTCTGCTGGCCTGTATGACCTCCACAGCCA
GGCCCTGGGCCCAAGCCCCTTGTCCCTTCTCCACTGCCCCTCTTTCCAGACAGTAAAGGCCATGGTCAGTGTGTTTTTCTCTTGTAAACA
AACCCCAGCTTGTTTAACAGAAATGCTAATAACCTACTGGGAAAGATGGAGGTCTAAATTACCTCCAGGGTTTTTCTGGGGGTTTATCAC
CAGTGTGGGTCCCTTCTGATACCACCAGGTTCACTCCAGGCAGAGTGGGGCGGAAGGCTGCTGAGGATATGGGTCAGTTACAGCAGCCCT
CACCTCAAAGGGCTGGCCTGCTTCTCAGCCTACATTCATTTGCAAGCTTCAATCTCTGGACCATCTGGTGTTCACAGGTGTTAGAGGGTT
AGGGGTTAGGGGCTAGTTTTGGATTTGATTCATAGGTAGGAGGGCTTAGATTTTAAGGCACTTCTGAAAGTCAATCCCTGGACAAGGCAG
TCATCACATAAGAACAGCTACCTTCTCCACTTGGTGGCACAAGAGGTAGGGAGGGGAGTATGGGTTCATTTGGCTTCGCATTATGCAAGG
TGAAACCGTTTGTTTTCCCTCTCCATTTTCCCTAACTAAATGAAAAGGACACATTCTGAAATCCCTTTTGTTGGAGAATAAGTCAGTCTG
AGGGGAAATGGGAGGCCAGAGATGAGAACCCTTTGAAAAGATTGTAAAATACTGATTTTCATTCTTTCAAGCTTATTTGTAAATACCTAT
TTGAATGCTGTGTATTTGTACAGGAATTTGAGCAAAAAATGTATAGAGTGTGATGTCCAATTGGTATTCAGCACTATAAATGTGTTTTTA
ACCTCCCGCATTCTGTGCTTATTTAAAACAAGGAAACTTCTAACCATTTCTTTTGTGTATTCATGTTTAAAGAAAAAAAGTGATTTAAAA
ATGATCTTACCTGTACCAGAAAAGCAAAGTTAAAGGAAACAAAATTTGTACCATTGTCCCAAGAGGTATTTTACTGTATATATTGTGGTA
GCATGTTCAAAATCCAACAAGTAATGTGAATTTTAGATGTAAATATCTGCCACTTGATTTTTTTTCCCCCTTTCCCCACTTCCTTGACTG

>91085_91085_3_TKT-DOCK3_TKT_chr3_53289852_ENST00000462138_DOCK3_chr3_50927457_ENST00000266037_length(amino acids)=1967AA_BP=
MKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWG
NEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFFLSLKSFTYNTIGEDTDVFFSLYDMR
EGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPPHLHYRRPYGCAVLSILDVLQSLTE
VKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRND
LYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCS
TKDKGEKKLFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKL
TQNVDLLALLKWKAFPDRIMDVLGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKH
FAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLF
TQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKEL
LICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHFQHL
LDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEI
ITSAKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKL
DSMVSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINK
EEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYES
LYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQC
DAQYLQIYAVTPIPDYVDVLQMDRVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVE
VSPLENAIQVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYINKHPGDAEKITQLKELMQEQVHVL
GVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPESIKMTHRHSPMNLMGTGRHSSSS
LSSHASSEAGNMVMLGDGSMGDAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKY
RHAREMMLLLPTYRDRPSSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPNLSVAEKGHYSLHFDAFHHPLGDTPPALPARTLRKSP
LHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPC

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Fusion Gene PPI Analysis for TKT-DOCK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TKT-DOCK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TKT-DOCK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource