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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TLE3-YWHAH (FusionGDB2 ID:91125)

Fusion Gene Summary for TLE3-YWHAH

check button Fusion gene summary
Fusion gene informationFusion gene name: TLE3-YWHAH
Fusion gene ID: 91125
HgeneTgene
Gene symbol

TLE3

YWHAH

Gene ID

7090

7533

Gene nameTLE family member 3, transcriptional corepressortyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
SynonymsESG|ESG3|GRG3|HsT18976YWHA1
Cytomap

15q23

22q12.3

Type of geneprotein-codingprotein-coding
Descriptiontransducin-like enhancer protein 3enhancer of split groucho 3enhancer of split groucho-like protein 3transducin like enhancer of split 3transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)transducin-like enhancer of split 3 short isoform14-3-3 protein eta14-3-3 etatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000317509, ENST00000440567, 
ENST00000442299, ENST00000451782, 
ENST00000539550, ENST00000557907, 
ENST00000557997, ENST00000558201, 
ENST00000558379, ENST00000558939, 
ENST00000559048, ENST00000559191, 
ENST00000559929, ENST00000560589, 
ENST00000560939, ENST00000559574, 
ENST00000471374, ENST00000248975, 
ENST00000397492, 
Fusion gene scores* DoF score14 X 14 X 6=11769 X 7 X 6=378
# samples 1613
** MAII scorelog2(16/1176*10)=-2.877744249949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/378*10)=-1.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TLE3 [Title/Abstract] AND YWHAH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTLE3(70345566)-YWHAH(32352126), # samples:2
TLE3(70345565)-YWHAH(32352125), # samples:2
Anticipated loss of major functional domain due to fusion event.TLE3-YWHAH seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYWHAH

GO:0002028

regulation of sodium ion transport

16728661

TgeneYWHAH

GO:0006713

glucocorticoid catabolic process

15790729

TgeneYWHAH

GO:0042921

glucocorticoid receptor signaling pathway

15790729

TgeneYWHAH

GO:0045893

positive regulation of transcription, DNA-templated

15790729

TgeneYWHAH

GO:0086010

membrane depolarization during action potential

16728661

TgeneYWHAH

GO:2000649

regulation of sodium ion transmembrane transporter activity

16728661


check buttonFusion gene breakpoints across TLE3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across YWHAH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8Q7-01ATLE3chr15

70345566

-YWHAHchr22

32352126

+
ChimerDB4ESCATCGA-VR-A8Q7TLE3chr15

70345565

-YWHAHchr22

32352125

+
ChimerDB4ESCATCGA-VR-A8Q7TLE3chr15

70345566

-YWHAHchr22

32352126

+


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Fusion Gene ORF analysis for TLE3-YWHAH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000317509ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000317509ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000440567ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000440567ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000442299ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000442299ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000451782ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000451782ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000539550ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000539550ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000557907ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000557907ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000557997ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000557997ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000558201ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000558201ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000558379ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000558379ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000558939ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000558939ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000559048ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000559048ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000559191ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000559191ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000559929ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000559929ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000560589ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000560589ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
5CDS-3UTRENST00000560939ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
5CDS-3UTRENST00000560939ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000317509ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000317509ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000317509ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000317509ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000440567ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000440567ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000440567ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000440567ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000442299ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000442299ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000442299ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000442299ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000451782ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000451782ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000451782ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000451782ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000539550ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000539550ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000557907ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000557907ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000557907ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000557907ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000557997ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000557997ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000557997ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000557997ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000558201ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000558201ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000558201ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000558201ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000558379ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000558379ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000558379ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000558379ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000558939ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000558939ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000558939ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000558939ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000559048ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000559048ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000559048ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000559048ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000559191ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000559191ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000559929ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000559929ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000559929ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000559929ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000560589ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000560589ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000560589ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000560589ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000560939ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000560939ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
Frame-shiftENST00000560939ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
Frame-shiftENST00000560939ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
In-frameENST00000539550ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
In-frameENST00000539550ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
In-frameENST00000559191ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
In-frameENST00000559191ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
intron-3CDSENST00000559574ENST00000248975TLE3chr15

70345566

-YWHAHchr22

32352126

+
intron-3CDSENST00000559574ENST00000248975TLE3chr15

70345565

-YWHAHchr22

32352125

+
intron-3CDSENST00000559574ENST00000397492TLE3chr15

70345566

-YWHAHchr22

32352126

+
intron-3CDSENST00000559574ENST00000397492TLE3chr15

70345565

-YWHAHchr22

32352125

+
intron-3UTRENST00000559574ENST00000471374TLE3chr15

70345566

-YWHAHchr22

32352126

+
intron-3UTRENST00000559574ENST00000471374TLE3chr15

70345565

-YWHAHchr22

32352125

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539550TLE3chr1570345566-ENST00000397492YWHAHchr2232352126+32981833692486805
ENST00000559191TLE3chr1570345566-ENST00000248975YWHAHchr2232352126+24439782521631459
ENST00000539550TLE3chr1570345565-ENST00000397492YWHAHchr2232352125+32981833692486805
ENST00000559191TLE3chr1570345565-ENST00000248975YWHAHchr2232352125+24439782521631459

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539550ENST00000397492TLE3chr1570345566-YWHAHchr2232352126+0.0140980040.98590195
ENST00000559191ENST00000248975TLE3chr1570345566-YWHAHchr2232352126+0.004102970.99589705
ENST00000539550ENST00000397492TLE3chr1570345565-YWHAHchr2232352125+0.0140980040.98590195
ENST00000559191ENST00000248975TLE3chr1570345565-YWHAHchr2232352125+0.004102970.99589705

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Fusion Genomic Features for TLE3-YWHAH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TLE3chr1570345565-YWHAHchr2232352125+4.13E-060.9999958
TLE3chr1570345565-YWHAHchr2232352125+4.13E-060.9999958
TLE3chr1570345565-YWHAHchr2232352125+4.13E-060.9999958
TLE3chr1570345565-YWHAHchr2232352125+4.13E-060.9999958

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for TLE3-YWHAH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:70345566/chr22:32352126)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720225_228649761.0MotifNuclear localization signal
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720225_228658770.0MotifNuclear localization signal
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720225_228653765.0MotifNuclear localization signal
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720225_228653765.0MotifNuclear localization signal
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720225_228661773.0MotifNuclear localization signal
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619225_228661773.0MotifNuclear localization signal
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720225_228649761.0MotifNuclear localization signal
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720225_228658770.0MotifNuclear localization signal
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720225_228653765.0MotifNuclear localization signal
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720225_228653765.0MotifNuclear localization signal
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720225_228661773.0MotifNuclear localization signal
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619225_228661773.0MotifNuclear localization signal
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720132_199649761.0RegionGP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-17201_131649761.0RegionQ domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720200_268649761.0RegionCcN domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720269_452649761.0RegionSP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720132_199658770.0RegionGP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-17201_131658770.0RegionQ domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720200_268658770.0RegionCcN domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720269_452658770.0RegionSP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720132_199653765.0RegionGP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-17201_131653765.0RegionQ domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720200_268653765.0RegionCcN domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720269_452653765.0RegionSP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720132_199653765.0RegionGP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-17201_131653765.0RegionQ domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720200_268653765.0RegionCcN domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720269_452653765.0RegionSP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720132_199661773.0RegionGP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-17201_131661773.0RegionQ domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720200_268661773.0RegionCcN domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720269_452661773.0RegionSP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619132_199661773.0RegionGP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-16191_131661773.0RegionQ domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619200_268661773.0RegionCcN domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619269_452661773.0RegionSP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720132_199649761.0RegionGP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-17201_131649761.0RegionQ domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720200_268649761.0RegionCcN domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720269_452649761.0RegionSP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720132_199658770.0RegionGP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-17201_131658770.0RegionQ domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720200_268658770.0RegionCcN domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720269_452658770.0RegionSP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720132_199653765.0RegionGP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-17201_131653765.0RegionQ domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720200_268653765.0RegionCcN domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720269_452653765.0RegionSP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720132_199653765.0RegionGP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-17201_131653765.0RegionQ domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720200_268653765.0RegionCcN domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720269_452653765.0RegionSP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720132_199661773.0RegionGP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-17201_131661773.0RegionQ domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720200_268661773.0RegionCcN domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720269_452661773.0RegionSP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619132_199661773.0RegionGP domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-16191_131661773.0RegionQ domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619200_268661773.0RegionCcN domain
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619269_452661773.0RegionSP domain
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720484_522649761.0RepeatNote=WD 1
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720530_569649761.0RepeatNote=WD 2
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720574_613649761.0RepeatNote=WD 3
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720484_522658770.0RepeatNote=WD 1
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720530_569658770.0RepeatNote=WD 2
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720574_613658770.0RepeatNote=WD 3
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720616_655658770.0RepeatNote=WD 4
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720484_522653765.0RepeatNote=WD 1
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720530_569653765.0RepeatNote=WD 2
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720574_613653765.0RepeatNote=WD 3
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720616_655653765.0RepeatNote=WD 4
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720484_522653765.0RepeatNote=WD 1
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720530_569653765.0RepeatNote=WD 2
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720574_613653765.0RepeatNote=WD 3
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720616_655653765.0RepeatNote=WD 4
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720484_522661773.0RepeatNote=WD 1
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720530_569661773.0RepeatNote=WD 2
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720574_613661773.0RepeatNote=WD 3
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720616_655661773.0RepeatNote=WD 4
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619484_522661773.0RepeatNote=WD 1
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619530_569661773.0RepeatNote=WD 2
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619574_613661773.0RepeatNote=WD 3
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619616_655661773.0RepeatNote=WD 4
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720484_522649761.0RepeatNote=WD 1
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720530_569649761.0RepeatNote=WD 2
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720574_613649761.0RepeatNote=WD 3
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720484_522658770.0RepeatNote=WD 1
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720530_569658770.0RepeatNote=WD 2
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720574_613658770.0RepeatNote=WD 3
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720616_655658770.0RepeatNote=WD 4
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720484_522653765.0RepeatNote=WD 1
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720530_569653765.0RepeatNote=WD 2
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720574_613653765.0RepeatNote=WD 3
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720616_655653765.0RepeatNote=WD 4
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720484_522653765.0RepeatNote=WD 1
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720530_569653765.0RepeatNote=WD 2
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720574_613653765.0RepeatNote=WD 3
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720616_655653765.0RepeatNote=WD 4
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720484_522661773.0RepeatNote=WD 1
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720530_569661773.0RepeatNote=WD 2
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720574_613661773.0RepeatNote=WD 3
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720616_655661773.0RepeatNote=WD 4
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619484_522661773.0RepeatNote=WD 1
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619530_569661773.0RepeatNote=WD 2
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619574_613661773.0RepeatNote=WD 3
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619616_655661773.0RepeatNote=WD 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720616_655649761.0RepeatNote=WD 4
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720657_696649761.0RepeatNote=WD 5
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720698_737649761.0RepeatNote=WD 6
HgeneTLE3chr15:70345565chr22:32352125ENST00000317509-1720739_771649761.0RepeatNote=WD 7
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720657_696658770.0RepeatNote=WD 5
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720698_737658770.0RepeatNote=WD 6
HgeneTLE3chr15:70345565chr22:32352125ENST00000451782-1720739_771658770.0RepeatNote=WD 7
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720657_696653765.0RepeatNote=WD 5
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720698_737653765.0RepeatNote=WD 6
HgeneTLE3chr15:70345565chr22:32352125ENST00000557907-1720739_771653765.0RepeatNote=WD 7
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720657_696653765.0RepeatNote=WD 5
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720698_737653765.0RepeatNote=WD 6
HgeneTLE3chr15:70345565chr22:32352125ENST00000557997-1720739_771653765.0RepeatNote=WD 7
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720657_696661773.0RepeatNote=WD 5
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720698_737661773.0RepeatNote=WD 6
HgeneTLE3chr15:70345565chr22:32352125ENST00000558939-1720739_771661773.0RepeatNote=WD 7
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619657_696661773.0RepeatNote=WD 5
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619698_737661773.0RepeatNote=WD 6
HgeneTLE3chr15:70345565chr22:32352125ENST00000559048-1619739_771661773.0RepeatNote=WD 7
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720616_655649761.0RepeatNote=WD 4
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720657_696649761.0RepeatNote=WD 5
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720698_737649761.0RepeatNote=WD 6
HgeneTLE3chr15:70345566chr22:32352126ENST00000317509-1720739_771649761.0RepeatNote=WD 7
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720657_696658770.0RepeatNote=WD 5
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720698_737658770.0RepeatNote=WD 6
HgeneTLE3chr15:70345566chr22:32352126ENST00000451782-1720739_771658770.0RepeatNote=WD 7
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720657_696653765.0RepeatNote=WD 5
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720698_737653765.0RepeatNote=WD 6
HgeneTLE3chr15:70345566chr22:32352126ENST00000557907-1720739_771653765.0RepeatNote=WD 7
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720657_696653765.0RepeatNote=WD 5
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720698_737653765.0RepeatNote=WD 6
HgeneTLE3chr15:70345566chr22:32352126ENST00000557997-1720739_771653765.0RepeatNote=WD 7
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720657_696661773.0RepeatNote=WD 5
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720698_737661773.0RepeatNote=WD 6
HgeneTLE3chr15:70345566chr22:32352126ENST00000558939-1720739_771661773.0RepeatNote=WD 7
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619657_696661773.0RepeatNote=WD 5
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619698_737661773.0RepeatNote=WD 6
HgeneTLE3chr15:70345566chr22:32352126ENST00000559048-1619739_771661773.0RepeatNote=WD 7


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Fusion Gene Sequence for TLE3-YWHAH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91125_91125_1_TLE3-YWHAH_TLE3_chr15_70345565_ENST00000539550_YWHAH_chr22_32352125_ENST00000397492_length(transcript)=3298nt_BP=1833nt
AATATAACGTTCTGTTGAGATGAGAGGAACGCTCGCCCTTGTCAGCTCTTAAACCGCTCTTACTATGAGATGTCCTATGGCTTGAACATT
GAAATGCACAAGCAGACAGAGATTGCGAAGAGACTGAACACAATTTTAGCACAGATCATGCCTTTCCTGTCACAAGAGCACCAGCAGCAG
GTGGCGCAGGCAGTGGAGCGCGCCAAGCAGGTCACCATGACGGAGCTGAACGCCATCATCGGGGTACGTGGACTCCCCAATCTGCCTCTT
ACCCAGCAGCAGCTCCAGGCGCAGCACCTCTCCCATGCCACACACGGCCCCCCGGTCCAGTTGCCACCCCACCCGTCAGGTCTCCAGCCT
CCAGGAATCCCCCCAGTGACAGGGAGCAGCTCCGGGCTGCTGGCACTGGGCGCCCTGGGCAGCCAGGCCCATCTGACGGTGAAGGATGAG
AAGAACCACCATGAACTCGATCACAGAGAGAGAGAATCCAGTGCGAATAACTCTGTGTCACCCTCGGAAAGCCTCCGGGCCAGTGAGAAG
CACCGGGGCTCTGCGGACTACAGCATGGAAGCCAAGAAGCGGAAGGCGGAGGAGAAGGACAGCTTGAGCCGATACGACAGTGATGGAGAC
AAGAGTGATGATCTGGTGGTGGATGTTTCCAATGAGGACCCCGCAACGCCCCGGGTCAGCCCGGCACACTCCCCTCCTGAAAATGGGCTG
GACAAGGCCCGTAGCCTGAAAAAAGATGCCCCCACCAGCCCTGCCTCGGTGGCCTCTTCCAGTAGCACACCTTCCTCCAAGACCAAAGAC
CTTGGTCATAACGACAAATCCTCCACCCCTGGGCTCAAGTCCAACACACCAACCCCAAGGAACGACGCCCCAACTCCAGGCACCAGCACG
ACCCCAGGGCTCAGGTCGATGCCGGCCTCGGCTCTGCGCACGCCCATCTCCATCACCAGCTCCTATGCGGCGCCCTTCGCCATGATGAGC
CACCATGAGATGAACGGCTCCCTCACCAGTCCTGGCGCCTACGCCGGCCTCCACAACATCCCACCCCAGATGAGCGCCGCCGCCGCTGCT
GCAGCCGCTGCCTATGGCCGATCGCCAATGGTTGGTTTTGACCCTCACCCCCCGATGCGGGCCACAGGCCTCCCCTCAAGCCTGGCCTCC
ATTCCTGGAGGAAAACCAGCGTACTCATTCCATGTGAGTGCTGATGGGCAGATGCAGCCCGTGCCCTTCCCCCACGACGCCCTGGCAGGC
CCCGGCATCCCGAGGCACGCCCGGCAGATCAACACACTCAGCCACGGGGAGGTGGTGTGTGCCGTGACCATCAGCAACCCCACGAGGCAC
GTCTACACAGGTGGCAAGGGCTGCGTGAAGATCTGGGACATCAGCCAGCCAGGCAGCAAGAGCCCCATCTCCCAGCTGGACTGCCTGAAC
AGGGACAATTACATCCGCTCCTGCAAGCTGCTCCCTGATGGGCGCACGCTCATCGTGGGCGGCGAGGCCAGCACGCTCACCATCTGGGAC
CTGGCCTCGCCCACGCCCCGCATCAAGGCCGAGCTGACGTCCTCGGCTCCCGCCTGTTATGCCCTGGCCATTAGCCCTGACGCCAAAGTC
TGCTTCTCCTGCTGCAGCGATGGGAACATTGCTGTCTGGGACCTGCACAACCAGACCCTGGTCAGGCAGTTCCAGGGCCACACAGATGGG
GCCAGCTGCATAGACATCTCCCATGATGGCACCAAACTGTGGACAGGGGGCCTGGACAACACGGTGCGCTCCTGGGACCTGCGGGAGGGC
CGACAGCTACAGCAGCATGACTTCACTTCCCAGGTGACAGAGCTGAATGAACCTCTCTCCAATGAAGATCGAAATCTCCTCTCTGTGGCC
TACAAGAATGTGGTTGGTGCCAGGCGATCTTCCTGGAGGGTCATTAGCAGCATTGAGCAGAAAACCATGGCTGATGGAAACGAAAAGAAA
TTGGAGAAAGTTAAAGCTTACCGGGAGAAGATTGAGAAGGAGCTGGAGACAGTTTGCAATGATGTCCTGTCTCTGCTTGACAAGTTCCTG
ATCAAGAACTGCAATGATTTCCAGTATGAGAGCAAGGTGTTTTACCTGAAAATGAAGGGTGATTACTACCGCTACTTAGCAGAGGTCGCT
TCTGGGGAGAAGAAAAACAGTGTGGTCGAAGCTTCTGAAGCTGCCTACAAGGAAGCCTTTGAAATCAGCAAAGAGCAGATGCAACCCACG
CATCCCATCCGGCTGGGCCTGGCCCTCAACTTCTCCGTGTTCTACTATGAGATCCAGAATGCACCTGAGCAAGCCTGCCTCTTAGCCAAA
CAAGCCTTCGATGATGCCATAGCTGAGCTGGACACACTAAACGAGGATTCCTATAAGGACTCCACGCTGATCATGCAGTTGCTGCGAGAC
AACCTCACCCTCTGGACGAGCGACCAGCAGGATGAAGAAGCAGGAGAAGGCAACTGAAGATCCTTCAGGTCCCCTGGCCCTTCCTTCACC
CACCACCCCCATCATCACCGATTCTTCCTTGCCACAATCACTAAATATCTAGTGCTAAACCTATCTGTATTGGCAGCACAGCTACTCAGA
TCTGCACTCCTGTCTCTTGGGAAGCAGTTTCAGATAAATCATGGGCATTGCTGGACTGATGGTTGCTTTGAGCCCACAGGAGCTCCCTTT
TTGAATTGTGTGGAGAAGTGTGTTCTGATGAGGCATTTTACTATGCCTGTTGATCTATGGGAAATCTAGGCGAAAGTAATGGGGAAGATT
AGAAAGAATTAGCCAACCAGGCTACAGTTGATATTTAAAAGATCCATTTAAAACAAGCTGATAGTGTTTCGTTAAGCAGTACATCTTGTG
CATGCAAAAATGAATTCACCCCTCCCACCTCTTTCTTCAATTAATGGAAAACTGTTAAGGGAAGCTGATACAGAGAGACAACTTGCTCCT
TTCCATCAGCTTTATAATAAACTGTTTAACGTGAGGTTTCAGTAGCTCCTTGGTTTTGCCTCTTTAAATTATGACGTGCACAAACCTTCT
TTTCAATGCAATGCATCTGAAAGTTTTGATACTTGTAACTTTTTTTTTTTTTTGGTTGCAATTGTTTAAGAATCATGGATTTATTTTTTG
TAACTCTTTGGCTATTGTCCTTGTGTATCCTGACAGCGCCATGTGTGTCAGCCCATGTCAATCAAGATGGGTGATTATGAAATGCCAGAC

>91125_91125_1_TLE3-YWHAH_TLE3_chr15_70345565_ENST00000539550_YWHAH_chr22_32352125_ENST00000397492_length(amino acids)=805AA_BP=587
MSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSHATHGPPVQLPP
HPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLS
RYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDA
PTPGTSTTPGLRSMPASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVGFDPHPPMRATG
LPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPI
SQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQ
FQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTM
ADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEIS

--------------------------------------------------------------
>91125_91125_2_TLE3-YWHAH_TLE3_chr15_70345565_ENST00000559191_YWHAH_chr22_32352125_ENST00000248975_length(transcript)=2443nt_BP=978nt
CTTCGCCTGTCTGTGTGTGGTATCCGTAGGTCCGGGGCACTTTTTTTTTTGGTGTGTGTGTGTGTGCGTGCGCGCGTGTGTGTGTGTTGG
GTGTGTGTGTTTTGGGGGTTTGCCGGGGCGCGGAGAGGAGAGCCGGGCCGAGGGGAAGGAAGGAAGCCGTAGAGCTCCCCGGTCTCGGGC
TGCGTCTCCCCTCCAGCGCTCTCCTGCCTCGCCGCCGCCGCTGCTGCAGCCGCTGCCTATGGCCGATCGCCAATGGTTGGTTTTGACCCT
CACCCCCCGATGCGGGCCACAGGCCTCCCCTCAAGCCTGGCCTCCATTCCTGGAGGAAAACCAGCGTACTCATTCCATGTGAGTGCTGAT
GGGCAGATGCAGCCCGTGCCCTTCCCCCACGACGCCCTGGCAGGCCCCGGCATCCCGAGGCACGCCCGGCAGATCAACACACTCAGCCAC
GGGGAGGTGGTGTGTGCCGTGACCATCAGCAACCCCACGAGGCACGTCTACACAGGTGGCAAGGGCTGCGTGAAGATCTGGGACATCAGC
CAGCCAGGCAGCAAGAGCCCCATCTCCCAGCTGGACTGCCTGAACAGGGACAATTACATCCGCTCCTGCAAGCTGCTCCCTGATGGGCGC
ACGCTCATCGTGGGCGGCGAGGCCAGCACGCTCACCATCTGGGACCTGGCCTCGCCCACGCCCCGCATCAAGGCCGAGCTGACGTCCTCG
GCTCCCGCCTGTTATGCCCTGGCCATTAGCCCTGACGCCAAAGTCTGCTTCTCCTGCTGCAGCGATGGGAACATTGCTGTCTGGGACCTG
CACAACCAGACCCTGGTCAGGCAGTTCCAGGGCCACACAGATGGGGCCAGCTGCATAGACATCTCCCATGATGGCACCAAACTGTGGACA
GGGGGCCTGGACAACACGGTGCGCTCCTGGGACCTGCGGGAGGGCCGACAGCTACAGCAGCATGACTTCACTTCCCAGGTGACAGAGCTG
AATGAACCTCTCTCCAATGAAGATCGAAATCTCCTCTCTGTGGCCTACAAGAATGTGGTTGGTGCCAGGCGATCTTCCTGGAGGGTCATT
AGCAGCATTGAGCAGAAAACCATGGCTGATGGAAACGAAAAGAAATTGGAGAAAGTTAAAGCTTACCGGGAGAAGATTGAGAAGGAGCTG
GAGACAGTTTGCAATGATGTCCTGTCTCTGCTTGACAAGTTCCTGATCAAGAACTGCAATGATTTCCAGTATGAGAGCAAGGTGTTTTAC
CTGAAAATGAAGGGTGATTACTACCGCTACTTAGCAGAGGTCGCTTCTGGGGAGAAGAAAAACAGTGTGGTCGAAGCTTCTGAAGCTGCC
TACAAGGAAGCCTTTGAAATCAGCAAAGAGCAGATGCAACCCACGCATCCCATCCGGCTGGGCCTGGCCCTCAACTTCTCCGTGTTCTAC
TATGAGATCCAGAATGCACCTGAGCAAGCCTGCCTCTTAGCCAAACAAGCCTTCGATGATGCCATAGCTGAGCTGGACACACTAAACGAG
GATTCCTATAAGGACTCCACGCTGATCATGCAGTTGCTGCGAGACAACCTCACCCTCTGGACGAGCGACCAGCAGGATGAAGAAGCAGGA
GAAGGCAACTGAAGATCCTTCAGGTCCCCTGGCCCTTCCTTCACCCACCACCCCCATCATCACCGATTCTTCCTTGCCACAATCACTAAA
TATCTAGTGCTAAACCTATCTGTATTGGCAGCACAGCTACTCAGATCTGCACTCCTGTCTCTTGGGAAGCAGTTTCAGATAAATCATGGG
CATTGCTGGACTGATGGTTGCTTTGAGCCCACAGGAGCTCCCTTTTTGAATTGTGTGGAGAAGTGTGTTCTGATGAGGCATTTTACTATG
CCTGTTGATCTATGGGAAATCTAGGCGAAAGTAATGGGGAAGATTAGAAAGAATTAGCCAACCAGGCTACAGTTGATATTTAAAAGATCC
ATTTAAAACAAGCTGATAGTGTTTCGTTAAGCAGTACATCTTGTGCATGCAAAAATGAATTCACCCCTCCCACCTCTTTCTTCAATTAAT
GGAAAACTGTTAAGGGAAGCTGATACAGAGAGACAACTTGCTCCTTTCCATCAGCTTTATAATAAACTGTTTAACGTGAGGTTTCAGTAG
CTCCTTGGTTTTGCCTCTTTAAATTATGACGTGCACAAACCTTCTTTTCAATGCAATGCATCTGAAAGTTTTGATACTTGTAACTTTTTT
TTTTTTTTGGTTGCAATTGTTTAAGAATCATGGATTTATTTTTTGTAACTCTTTGGCTATTGTCCTTGTGTATCCTGACAGCGCCATGTG
TGTCAGCCCATGTCAATCAAGATGGGTGATTATGAAATGCCAGACTTCTAAAATAAATGTTTTGGAATTCAATGGGTAAATAAATGCTGC

>91125_91125_2_TLE3-YWHAH_TLE3_chr15_70345565_ENST00000559191_YWHAH_chr22_32352125_ENST00000248975_length(amino acids)=459AA_BP=241
MVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCV
KIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGN
IAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQVTELNEPLSNEDRNLLSVAYKNVVGARR
SSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVV
EASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQ

--------------------------------------------------------------
>91125_91125_3_TLE3-YWHAH_TLE3_chr15_70345566_ENST00000539550_YWHAH_chr22_32352126_ENST00000397492_length(transcript)=3298nt_BP=1833nt
AATATAACGTTCTGTTGAGATGAGAGGAACGCTCGCCCTTGTCAGCTCTTAAACCGCTCTTACTATGAGATGTCCTATGGCTTGAACATT
GAAATGCACAAGCAGACAGAGATTGCGAAGAGACTGAACACAATTTTAGCACAGATCATGCCTTTCCTGTCACAAGAGCACCAGCAGCAG
GTGGCGCAGGCAGTGGAGCGCGCCAAGCAGGTCACCATGACGGAGCTGAACGCCATCATCGGGGTACGTGGACTCCCCAATCTGCCTCTT
ACCCAGCAGCAGCTCCAGGCGCAGCACCTCTCCCATGCCACACACGGCCCCCCGGTCCAGTTGCCACCCCACCCGTCAGGTCTCCAGCCT
CCAGGAATCCCCCCAGTGACAGGGAGCAGCTCCGGGCTGCTGGCACTGGGCGCCCTGGGCAGCCAGGCCCATCTGACGGTGAAGGATGAG
AAGAACCACCATGAACTCGATCACAGAGAGAGAGAATCCAGTGCGAATAACTCTGTGTCACCCTCGGAAAGCCTCCGGGCCAGTGAGAAG
CACCGGGGCTCTGCGGACTACAGCATGGAAGCCAAGAAGCGGAAGGCGGAGGAGAAGGACAGCTTGAGCCGATACGACAGTGATGGAGAC
AAGAGTGATGATCTGGTGGTGGATGTTTCCAATGAGGACCCCGCAACGCCCCGGGTCAGCCCGGCACACTCCCCTCCTGAAAATGGGCTG
GACAAGGCCCGTAGCCTGAAAAAAGATGCCCCCACCAGCCCTGCCTCGGTGGCCTCTTCCAGTAGCACACCTTCCTCCAAGACCAAAGAC
CTTGGTCATAACGACAAATCCTCCACCCCTGGGCTCAAGTCCAACACACCAACCCCAAGGAACGACGCCCCAACTCCAGGCACCAGCACG
ACCCCAGGGCTCAGGTCGATGCCGGCCTCGGCTCTGCGCACGCCCATCTCCATCACCAGCTCCTATGCGGCGCCCTTCGCCATGATGAGC
CACCATGAGATGAACGGCTCCCTCACCAGTCCTGGCGCCTACGCCGGCCTCCACAACATCCCACCCCAGATGAGCGCCGCCGCCGCTGCT
GCAGCCGCTGCCTATGGCCGATCGCCAATGGTTGGTTTTGACCCTCACCCCCCGATGCGGGCCACAGGCCTCCCCTCAAGCCTGGCCTCC
ATTCCTGGAGGAAAACCAGCGTACTCATTCCATGTGAGTGCTGATGGGCAGATGCAGCCCGTGCCCTTCCCCCACGACGCCCTGGCAGGC
CCCGGCATCCCGAGGCACGCCCGGCAGATCAACACACTCAGCCACGGGGAGGTGGTGTGTGCCGTGACCATCAGCAACCCCACGAGGCAC
GTCTACACAGGTGGCAAGGGCTGCGTGAAGATCTGGGACATCAGCCAGCCAGGCAGCAAGAGCCCCATCTCCCAGCTGGACTGCCTGAAC
AGGGACAATTACATCCGCTCCTGCAAGCTGCTCCCTGATGGGCGCACGCTCATCGTGGGCGGCGAGGCCAGCACGCTCACCATCTGGGAC
CTGGCCTCGCCCACGCCCCGCATCAAGGCCGAGCTGACGTCCTCGGCTCCCGCCTGTTATGCCCTGGCCATTAGCCCTGACGCCAAAGTC
TGCTTCTCCTGCTGCAGCGATGGGAACATTGCTGTCTGGGACCTGCACAACCAGACCCTGGTCAGGCAGTTCCAGGGCCACACAGATGGG
GCCAGCTGCATAGACATCTCCCATGATGGCACCAAACTGTGGACAGGGGGCCTGGACAACACGGTGCGCTCCTGGGACCTGCGGGAGGGC
CGACAGCTACAGCAGCATGACTTCACTTCCCAGGTGACAGAGCTGAATGAACCTCTCTCCAATGAAGATCGAAATCTCCTCTCTGTGGCC
TACAAGAATGTGGTTGGTGCCAGGCGATCTTCCTGGAGGGTCATTAGCAGCATTGAGCAGAAAACCATGGCTGATGGAAACGAAAAGAAA
TTGGAGAAAGTTAAAGCTTACCGGGAGAAGATTGAGAAGGAGCTGGAGACAGTTTGCAATGATGTCCTGTCTCTGCTTGACAAGTTCCTG
ATCAAGAACTGCAATGATTTCCAGTATGAGAGCAAGGTGTTTTACCTGAAAATGAAGGGTGATTACTACCGCTACTTAGCAGAGGTCGCT
TCTGGGGAGAAGAAAAACAGTGTGGTCGAAGCTTCTGAAGCTGCCTACAAGGAAGCCTTTGAAATCAGCAAAGAGCAGATGCAACCCACG
CATCCCATCCGGCTGGGCCTGGCCCTCAACTTCTCCGTGTTCTACTATGAGATCCAGAATGCACCTGAGCAAGCCTGCCTCTTAGCCAAA
CAAGCCTTCGATGATGCCATAGCTGAGCTGGACACACTAAACGAGGATTCCTATAAGGACTCCACGCTGATCATGCAGTTGCTGCGAGAC
AACCTCACCCTCTGGACGAGCGACCAGCAGGATGAAGAAGCAGGAGAAGGCAACTGAAGATCCTTCAGGTCCCCTGGCCCTTCCTTCACC
CACCACCCCCATCATCACCGATTCTTCCTTGCCACAATCACTAAATATCTAGTGCTAAACCTATCTGTATTGGCAGCACAGCTACTCAGA
TCTGCACTCCTGTCTCTTGGGAAGCAGTTTCAGATAAATCATGGGCATTGCTGGACTGATGGTTGCTTTGAGCCCACAGGAGCTCCCTTT
TTGAATTGTGTGGAGAAGTGTGTTCTGATGAGGCATTTTACTATGCCTGTTGATCTATGGGAAATCTAGGCGAAAGTAATGGGGAAGATT
AGAAAGAATTAGCCAACCAGGCTACAGTTGATATTTAAAAGATCCATTTAAAACAAGCTGATAGTGTTTCGTTAAGCAGTACATCTTGTG
CATGCAAAAATGAATTCACCCCTCCCACCTCTTTCTTCAATTAATGGAAAACTGTTAAGGGAAGCTGATACAGAGAGACAACTTGCTCCT
TTCCATCAGCTTTATAATAAACTGTTTAACGTGAGGTTTCAGTAGCTCCTTGGTTTTGCCTCTTTAAATTATGACGTGCACAAACCTTCT
TTTCAATGCAATGCATCTGAAAGTTTTGATACTTGTAACTTTTTTTTTTTTTTGGTTGCAATTGTTTAAGAATCATGGATTTATTTTTTG
TAACTCTTTGGCTATTGTCCTTGTGTATCCTGACAGCGCCATGTGTGTCAGCCCATGTCAATCAAGATGGGTGATTATGAAATGCCAGAC

>91125_91125_3_TLE3-YWHAH_TLE3_chr15_70345566_ENST00000539550_YWHAH_chr22_32352126_ENST00000397492_length(amino acids)=805AA_BP=587
MSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSHATHGPPVQLPP
HPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLS
RYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDA
PTPGTSTTPGLRSMPASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVGFDPHPPMRATG
LPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPI
SQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQ
FQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTM
ADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEIS

--------------------------------------------------------------
>91125_91125_4_TLE3-YWHAH_TLE3_chr15_70345566_ENST00000559191_YWHAH_chr22_32352126_ENST00000248975_length(transcript)=2443nt_BP=978nt
CTTCGCCTGTCTGTGTGTGGTATCCGTAGGTCCGGGGCACTTTTTTTTTTGGTGTGTGTGTGTGTGCGTGCGCGCGTGTGTGTGTGTTGG
GTGTGTGTGTTTTGGGGGTTTGCCGGGGCGCGGAGAGGAGAGCCGGGCCGAGGGGAAGGAAGGAAGCCGTAGAGCTCCCCGGTCTCGGGC
TGCGTCTCCCCTCCAGCGCTCTCCTGCCTCGCCGCCGCCGCTGCTGCAGCCGCTGCCTATGGCCGATCGCCAATGGTTGGTTTTGACCCT
CACCCCCCGATGCGGGCCACAGGCCTCCCCTCAAGCCTGGCCTCCATTCCTGGAGGAAAACCAGCGTACTCATTCCATGTGAGTGCTGAT
GGGCAGATGCAGCCCGTGCCCTTCCCCCACGACGCCCTGGCAGGCCCCGGCATCCCGAGGCACGCCCGGCAGATCAACACACTCAGCCAC
GGGGAGGTGGTGTGTGCCGTGACCATCAGCAACCCCACGAGGCACGTCTACACAGGTGGCAAGGGCTGCGTGAAGATCTGGGACATCAGC
CAGCCAGGCAGCAAGAGCCCCATCTCCCAGCTGGACTGCCTGAACAGGGACAATTACATCCGCTCCTGCAAGCTGCTCCCTGATGGGCGC
ACGCTCATCGTGGGCGGCGAGGCCAGCACGCTCACCATCTGGGACCTGGCCTCGCCCACGCCCCGCATCAAGGCCGAGCTGACGTCCTCG
GCTCCCGCCTGTTATGCCCTGGCCATTAGCCCTGACGCCAAAGTCTGCTTCTCCTGCTGCAGCGATGGGAACATTGCTGTCTGGGACCTG
CACAACCAGACCCTGGTCAGGCAGTTCCAGGGCCACACAGATGGGGCCAGCTGCATAGACATCTCCCATGATGGCACCAAACTGTGGACA
GGGGGCCTGGACAACACGGTGCGCTCCTGGGACCTGCGGGAGGGCCGACAGCTACAGCAGCATGACTTCACTTCCCAGGTGACAGAGCTG
AATGAACCTCTCTCCAATGAAGATCGAAATCTCCTCTCTGTGGCCTACAAGAATGTGGTTGGTGCCAGGCGATCTTCCTGGAGGGTCATT
AGCAGCATTGAGCAGAAAACCATGGCTGATGGAAACGAAAAGAAATTGGAGAAAGTTAAAGCTTACCGGGAGAAGATTGAGAAGGAGCTG
GAGACAGTTTGCAATGATGTCCTGTCTCTGCTTGACAAGTTCCTGATCAAGAACTGCAATGATTTCCAGTATGAGAGCAAGGTGTTTTAC
CTGAAAATGAAGGGTGATTACTACCGCTACTTAGCAGAGGTCGCTTCTGGGGAGAAGAAAAACAGTGTGGTCGAAGCTTCTGAAGCTGCC
TACAAGGAAGCCTTTGAAATCAGCAAAGAGCAGATGCAACCCACGCATCCCATCCGGCTGGGCCTGGCCCTCAACTTCTCCGTGTTCTAC
TATGAGATCCAGAATGCACCTGAGCAAGCCTGCCTCTTAGCCAAACAAGCCTTCGATGATGCCATAGCTGAGCTGGACACACTAAACGAG
GATTCCTATAAGGACTCCACGCTGATCATGCAGTTGCTGCGAGACAACCTCACCCTCTGGACGAGCGACCAGCAGGATGAAGAAGCAGGA
GAAGGCAACTGAAGATCCTTCAGGTCCCCTGGCCCTTCCTTCACCCACCACCCCCATCATCACCGATTCTTCCTTGCCACAATCACTAAA
TATCTAGTGCTAAACCTATCTGTATTGGCAGCACAGCTACTCAGATCTGCACTCCTGTCTCTTGGGAAGCAGTTTCAGATAAATCATGGG
CATTGCTGGACTGATGGTTGCTTTGAGCCCACAGGAGCTCCCTTTTTGAATTGTGTGGAGAAGTGTGTTCTGATGAGGCATTTTACTATG
CCTGTTGATCTATGGGAAATCTAGGCGAAAGTAATGGGGAAGATTAGAAAGAATTAGCCAACCAGGCTACAGTTGATATTTAAAAGATCC
ATTTAAAACAAGCTGATAGTGTTTCGTTAAGCAGTACATCTTGTGCATGCAAAAATGAATTCACCCCTCCCACCTCTTTCTTCAATTAAT
GGAAAACTGTTAAGGGAAGCTGATACAGAGAGACAACTTGCTCCTTTCCATCAGCTTTATAATAAACTGTTTAACGTGAGGTTTCAGTAG
CTCCTTGGTTTTGCCTCTTTAAATTATGACGTGCACAAACCTTCTTTTCAATGCAATGCATCTGAAAGTTTTGATACTTGTAACTTTTTT
TTTTTTTTGGTTGCAATTGTTTAAGAATCATGGATTTATTTTTTGTAACTCTTTGGCTATTGTCCTTGTGTATCCTGACAGCGCCATGTG
TGTCAGCCCATGTCAATCAAGATGGGTGATTATGAAATGCCAGACTTCTAAAATAAATGTTTTGGAATTCAATGGGTAAATAAATGCTGC

>91125_91125_4_TLE3-YWHAH_TLE3_chr15_70345566_ENST00000559191_YWHAH_chr22_32352126_ENST00000248975_length(amino acids)=459AA_BP=241
MVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCV
KIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGN
IAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQVTELNEPLSNEDRNLLSVAYKNVVGARR
SSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVV
EASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TLE3-YWHAH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TLE3-YWHAH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TLE3-YWHAH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource