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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TLK1-SSB (FusionGDB2 ID:91146)

Fusion Gene Summary for TLK1-SSB

check button Fusion gene summary
Fusion gene informationFusion gene name: TLK1-SSB
Fusion gene ID: 91146
HgeneTgene
Gene symbol

TLK1

SSB

Gene ID

9874

6741

Gene nametousled like kinase 1small RNA binding exonuclease protection factor La
SynonymsPKU-betaLARP3|La|La/SSB
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase tousled-like 1SNARE protein kinase SNAKserine threonine protein kinaselupus La proteinLa ribonucleoprotein domain family, member 3SS-BSS-B/La proteinSjogren syndrome antigen Bautoantigen Lala autoantigenlupus La antigensjoegren syndrome type B antigen
Modification date2020032920200313
UniProtAcc.

P81877

Ensembl transtripts involved in fusion geneENST00000486857, ENST00000521943, 
ENST00000360843, ENST00000431350, 
ENST00000442919, ENST00000434911, 
ENST00000260956, ENST00000409333, 
Fusion gene scores* DoF score13 X 15 X 6=11709 X 12 X 7=756
# samples 1815
** MAII scorelog2(18/1170*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/756*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TLK1 [Title/Abstract] AND SSB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTLK1(171939291)-SSB(170661984), # samples:3
Anticipated loss of major functional domain due to fusion event.TLK1-SSB seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
TLK1-SSB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TLK1-SSB seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TLK1-SSB seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTLK1

GO:0001672

regulation of chromatin assembly or disassembly

12660173

HgeneTLK1

GO:0006468

protein phosphorylation

12660173

HgeneTLK1

GO:0006886

intracellular protein transport

10588641

HgeneTLK1

GO:0035556

intracellular signal transduction

12660173

TgeneSSB

GO:0075522

IRES-dependent viral translational initiation

12384597

TgeneSSB

GO:1903608

protein localization to cytoplasmic stress granule

24965446


check buttonFusion gene breakpoints across TLK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SSB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A094-01ATLK1chr2

171939291

-SSBchr2

170661984

+
ChimerDB4BRCATCGA-A8-A094TLK1chr2

171939290

-SSBchr2

170661983

+


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Fusion Gene ORF analysis for TLK1-SSB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000486857ENST00000260956TLK1chr2

171939291

-SSBchr2

170661984

+
5UTR-3CDSENST00000486857ENST00000260956TLK1chr2

171939290

-SSBchr2

170661983

+
5UTR-3CDSENST00000486857ENST00000409333TLK1chr2

171939291

-SSBchr2

170661984

+
5UTR-3CDSENST00000486857ENST00000409333TLK1chr2

171939290

-SSBchr2

170661983

+
Frame-shiftENST00000521943ENST00000260956TLK1chr2

171939291

-SSBchr2

170661984

+
Frame-shiftENST00000521943ENST00000260956TLK1chr2

171939290

-SSBchr2

170661983

+
Frame-shiftENST00000521943ENST00000409333TLK1chr2

171939291

-SSBchr2

170661984

+
Frame-shiftENST00000521943ENST00000409333TLK1chr2

171939290

-SSBchr2

170661983

+
In-frameENST00000360843ENST00000260956TLK1chr2

171939291

-SSBchr2

170661984

+
In-frameENST00000360843ENST00000260956TLK1chr2

171939290

-SSBchr2

170661983

+
In-frameENST00000360843ENST00000409333TLK1chr2

171939291

-SSBchr2

170661984

+
In-frameENST00000360843ENST00000409333TLK1chr2

171939290

-SSBchr2

170661983

+
In-frameENST00000431350ENST00000260956TLK1chr2

171939291

-SSBchr2

170661984

+
In-frameENST00000431350ENST00000260956TLK1chr2

171939290

-SSBchr2

170661983

+
In-frameENST00000431350ENST00000409333TLK1chr2

171939291

-SSBchr2

170661984

+
In-frameENST00000431350ENST00000409333TLK1chr2

171939290

-SSBchr2

170661983

+
In-frameENST00000442919ENST00000260956TLK1chr2

171939291

-SSBchr2

170661984

+
In-frameENST00000442919ENST00000260956TLK1chr2

171939290

-SSBchr2

170661983

+
In-frameENST00000442919ENST00000409333TLK1chr2

171939291

-SSBchr2

170661984

+
In-frameENST00000442919ENST00000409333TLK1chr2

171939290

-SSBchr2

170661983

+
intron-3CDSENST00000434911ENST00000260956TLK1chr2

171939291

-SSBchr2

170661984

+
intron-3CDSENST00000434911ENST00000260956TLK1chr2

171939290

-SSBchr2

170661983

+
intron-3CDSENST00000434911ENST00000409333TLK1chr2

171939291

-SSBchr2

170661984

+
intron-3CDSENST00000434911ENST00000409333TLK1chr2

171939290

-SSBchr2

170661983

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360843TLK1chr2171939291-ENST00000260956SSBchr2170661984+22047354021895497
ENST00000360843TLK1chr2171939291-ENST00000409333SSBchr2170661984+22047354021895497
ENST00000431350TLK1chr2171939291-ENST00000260956SSBchr2170661984+22047354021895497
ENST00000431350TLK1chr2171939291-ENST00000409333SSBchr2170661984+22047354021895497
ENST00000442919TLK1chr2171939291-ENST00000260956SSBchr2170661984+22718024691962497
ENST00000442919TLK1chr2171939291-ENST00000409333SSBchr2170661984+22718024691962497
ENST00000360843TLK1chr2171939290-ENST00000260956SSBchr2170661983+22047354021895497
ENST00000360843TLK1chr2171939290-ENST00000409333SSBchr2170661983+22047354021895497
ENST00000431350TLK1chr2171939290-ENST00000260956SSBchr2170661983+22047354021895497
ENST00000431350TLK1chr2171939290-ENST00000409333SSBchr2170661983+22047354021895497
ENST00000442919TLK1chr2171939290-ENST00000260956SSBchr2170661983+22718024691962497
ENST00000442919TLK1chr2171939290-ENST00000409333SSBchr2170661983+22718024691962497

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360843ENST00000260956TLK1chr2171939291-SSBchr2170661984+0.0005194130.99948066
ENST00000360843ENST00000409333TLK1chr2171939291-SSBchr2170661984+0.0005194130.99948066
ENST00000431350ENST00000260956TLK1chr2171939291-SSBchr2170661984+0.0005194130.99948066
ENST00000431350ENST00000409333TLK1chr2171939291-SSBchr2170661984+0.0005194130.99948066
ENST00000442919ENST00000260956TLK1chr2171939291-SSBchr2170661984+0.0005675820.9994324
ENST00000442919ENST00000409333TLK1chr2171939291-SSBchr2170661984+0.0005675820.9994324
ENST00000360843ENST00000260956TLK1chr2171939290-SSBchr2170661983+0.0005194130.99948066
ENST00000360843ENST00000409333TLK1chr2171939290-SSBchr2170661983+0.0005194130.99948066
ENST00000431350ENST00000260956TLK1chr2171939290-SSBchr2170661983+0.0005194130.99948066
ENST00000431350ENST00000409333TLK1chr2171939290-SSBchr2170661983+0.0005194130.99948066
ENST00000442919ENST00000260956TLK1chr2171939290-SSBchr2170661983+0.0005675820.9994324
ENST00000442919ENST00000409333TLK1chr2171939290-SSBchr2170661983+0.0005675820.9994324

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Fusion Genomic Features for TLK1-SSB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TLK1chr2171939290-SSBchr2170661983+3.58E-091
TLK1chr2171939290-SSBchr2170661983+3.58E-091
TLK1chr2171939290-SSBchr2170661983+3.58E-091
TLK1chr2171939290-SSBchr2170661983+3.58E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TLK1-SSB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:171939291/chr2:170661984)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SSB

P81877

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSSBchr2:171939290chr2:170661983ENST00000260956112111_18722409.0DomainRRM
TgeneSSBchr2:171939290chr2:170661983ENST00000260956112227_34822409.0DomainxRRM
TgeneSSBchr2:171939290chr2:170661983ENST00000409333112111_18722409.0DomainRRM
TgeneSSBchr2:171939290chr2:170661983ENST00000409333112227_34822409.0DomainxRRM
TgeneSSBchr2:171939291chr2:170661984ENST00000260956112111_18722409.0DomainRRM
TgeneSSBchr2:171939291chr2:170661984ENST00000260956112227_34822409.0DomainxRRM
TgeneSSBchr2:171939291chr2:170661984ENST00000409333112111_18722409.0DomainRRM
TgeneSSBchr2:171939291chr2:170661984ENST00000409333112227_34822409.0DomainxRRM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLK1chr2:171939290chr2:170661983ENST00000360843-322230_281110788.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000360843-322397_445110788.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000431350-321230_281110767.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000431350-321397_445110767.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000434911-119230_2810671.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000434911-119397_4450671.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000442919-321230_28162719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000442919-321397_44562719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000521943-321230_28162719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000521943-321397_44562719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000360843-322230_281110788.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000360843-322397_445110788.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000431350-321230_281110767.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000431350-321397_445110767.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000434911-119230_2810671.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000434911-119397_4450671.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000442919-321230_28162719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000442919-321397_44562719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000521943-321230_28162719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939291chr2:170661984ENST00000521943-321397_44562719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:171939290chr2:170661983ENST00000360843-322456_734110788.0DomainProtein kinase
HgeneTLK1chr2:171939290chr2:170661983ENST00000431350-321456_734110767.0DomainProtein kinase
HgeneTLK1chr2:171939290chr2:170661983ENST00000434911-119456_7340671.0DomainProtein kinase
HgeneTLK1chr2:171939290chr2:170661983ENST00000442919-321456_73462719.0DomainProtein kinase
HgeneTLK1chr2:171939290chr2:170661983ENST00000521943-321456_73462719.0DomainProtein kinase
HgeneTLK1chr2:171939291chr2:170661984ENST00000360843-322456_734110788.0DomainProtein kinase
HgeneTLK1chr2:171939291chr2:170661984ENST00000431350-321456_734110767.0DomainProtein kinase
HgeneTLK1chr2:171939291chr2:170661984ENST00000434911-119456_7340671.0DomainProtein kinase
HgeneTLK1chr2:171939291chr2:170661984ENST00000442919-321456_73462719.0DomainProtein kinase
HgeneTLK1chr2:171939291chr2:170661984ENST00000521943-321456_73462719.0DomainProtein kinase
HgeneTLK1chr2:171939290chr2:170661983ENST00000360843-322462_470110788.0Nucleotide bindingATP
HgeneTLK1chr2:171939290chr2:170661983ENST00000431350-321462_470110767.0Nucleotide bindingATP
HgeneTLK1chr2:171939290chr2:170661983ENST00000434911-119462_4700671.0Nucleotide bindingATP
HgeneTLK1chr2:171939290chr2:170661983ENST00000442919-321462_47062719.0Nucleotide bindingATP
HgeneTLK1chr2:171939290chr2:170661983ENST00000521943-321462_47062719.0Nucleotide bindingATP
HgeneTLK1chr2:171939291chr2:170661984ENST00000360843-322462_470110788.0Nucleotide bindingATP
HgeneTLK1chr2:171939291chr2:170661984ENST00000431350-321462_470110767.0Nucleotide bindingATP
HgeneTLK1chr2:171939291chr2:170661984ENST00000434911-119462_4700671.0Nucleotide bindingATP
HgeneTLK1chr2:171939291chr2:170661984ENST00000442919-321462_47062719.0Nucleotide bindingATP
HgeneTLK1chr2:171939291chr2:170661984ENST00000521943-321462_47062719.0Nucleotide bindingATP
TgeneSSBchr2:171939290chr2:170661983ENST000002609561127_9922409.0DomainHTH La-type RNA-binding
TgeneSSBchr2:171939290chr2:170661983ENST000004093331127_9922409.0DomainHTH La-type RNA-binding
TgeneSSBchr2:171939291chr2:170661984ENST000002609561127_9922409.0DomainHTH La-type RNA-binding
TgeneSSBchr2:171939291chr2:170661984ENST000004093331127_9922409.0DomainHTH La-type RNA-binding


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Fusion Gene Sequence for TLK1-SSB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91146_91146_1_TLK1-SSB_TLK1_chr2_171939290_ENST00000360843_SSB_chr2_170661983_ENST00000260956_length(transcript)=2204nt_BP=735nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACT
GGAAGTACGGGCAGTTGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGT
GACAAAGAATCAGAGTATTATTTTGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTA
CCTTTGGAGATAATGATAAAATTCAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCA
GAACTCATGGAAATCAGTGAAGATAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGAT
GTAAAAAACAGATCTGTTTATATTAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTA
CTAAATATTCAGATGAGAAGAACATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTT
GTAGAGACCCCTGGCCAGAAGTACAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAA
CAAAATAAAGTGGAAGCTAAATTAAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAA
GAAAAGATTGGATGCTTGCTGAAATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGT
GAAATAAAATGGATAGACTTCGTCAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAA
GATGCAAATAATGGTAACCTACAATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAA
ATAATAGAAGACCAACAAGAATCCCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAG
CCTGGGTCTGGTAAAGGAAAAGTACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGT
GCAACTGGACCTGTGAAAAGAGCAAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGAC
CAGTAGTTTAGTAAACCAATTTTTTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAG
GTCCACTTCAATGTCCACCTGTGAGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGT
ATTGTTCTGTTTGTGTTATTTCAGATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGT

>91146_91146_1_TLK1-SSB_TLK1_chr2_171939290_ENST00000360843_SSB_chr2_170661983_ENST00000260956_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_2_TLK1-SSB_TLK1_chr2_171939290_ENST00000360843_SSB_chr2_170661983_ENST00000409333_length(transcript)=2204nt_BP=735nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACT
GGAAGTACGGGCAGTTGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGT
GACAAAGAATCAGAGTATTATTTTGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTA
CCTTTGGAGATAATGATAAAATTCAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCA
GAACTCATGGAAATCAGTGAAGATAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGAT
GTAAAAAACAGATCTGTTTATATTAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTA
CTAAATATTCAGATGAGAAGAACATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTT
GTAGAGACCCCTGGCCAGAAGTACAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAA
CAAAATAAAGTGGAAGCTAAATTAAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAA
GAAAAGATTGGATGCTTGCTGAAATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGT
GAAATAAAATGGATAGACTTCGTCAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAA
GATGCAAATAATGGTAACCTACAATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAA
ATAATAGAAGACCAACAAGAATCCCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAG
CCTGGGTCTGGTAAAGGAAAAGTACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGT
GCAACTGGACCTGTGAAAAGAGCAAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGAC
CAGTAGTTTAGTAAACCAATTTTTTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAG
GTCCACTTCAATGTCCACCTGTGAGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGT
ATTGTTCTGTTTGTGTTATTTCAGATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGT

>91146_91146_2_TLK1-SSB_TLK1_chr2_171939290_ENST00000360843_SSB_chr2_170661983_ENST00000409333_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_3_TLK1-SSB_TLK1_chr2_171939290_ENST00000431350_SSB_chr2_170661983_ENST00000260956_length(transcript)=2204nt_BP=735nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACT
GGAAGTACGGGCAGTTGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGT
GACAAAGAATCAGAGTATTATTTTGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTA
CCTTTGGAGATAATGATAAAATTCAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCA
GAACTCATGGAAATCAGTGAAGATAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGAT
GTAAAAAACAGATCTGTTTATATTAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTA
CTAAATATTCAGATGAGAAGAACATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTT
GTAGAGACCCCTGGCCAGAAGTACAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAA
CAAAATAAAGTGGAAGCTAAATTAAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAA
GAAAAGATTGGATGCTTGCTGAAATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGT
GAAATAAAATGGATAGACTTCGTCAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAA
GATGCAAATAATGGTAACCTACAATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAA
ATAATAGAAGACCAACAAGAATCCCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAG
CCTGGGTCTGGTAAAGGAAAAGTACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGT
GCAACTGGACCTGTGAAAAGAGCAAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGAC
CAGTAGTTTAGTAAACCAATTTTTTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAG
GTCCACTTCAATGTCCACCTGTGAGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGT
ATTGTTCTGTTTGTGTTATTTCAGATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGT

>91146_91146_3_TLK1-SSB_TLK1_chr2_171939290_ENST00000431350_SSB_chr2_170661983_ENST00000260956_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_4_TLK1-SSB_TLK1_chr2_171939290_ENST00000431350_SSB_chr2_170661983_ENST00000409333_length(transcript)=2204nt_BP=735nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACT
GGAAGTACGGGCAGTTGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGT
GACAAAGAATCAGAGTATTATTTTGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTA
CCTTTGGAGATAATGATAAAATTCAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCA
GAACTCATGGAAATCAGTGAAGATAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGAT
GTAAAAAACAGATCTGTTTATATTAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTA
CTAAATATTCAGATGAGAAGAACATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTT
GTAGAGACCCCTGGCCAGAAGTACAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAA
CAAAATAAAGTGGAAGCTAAATTAAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAA
GAAAAGATTGGATGCTTGCTGAAATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGT
GAAATAAAATGGATAGACTTCGTCAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAA
GATGCAAATAATGGTAACCTACAATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAA
ATAATAGAAGACCAACAAGAATCCCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAG
CCTGGGTCTGGTAAAGGAAAAGTACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGT
GCAACTGGACCTGTGAAAAGAGCAAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGAC
CAGTAGTTTAGTAAACCAATTTTTTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAG
GTCCACTTCAATGTCCACCTGTGAGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGT
ATTGTTCTGTTTGTGTTATTTCAGATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGT

>91146_91146_4_TLK1-SSB_TLK1_chr2_171939290_ENST00000431350_SSB_chr2_170661983_ENST00000409333_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_5_TLK1-SSB_TLK1_chr2_171939290_ENST00000442919_SSB_chr2_170661983_ENST00000260956_length(transcript)=2271nt_BP=802nt
AACTGATGCAGAGGTTACCCCACCGCCTCAGCCGCCACCCACAGCCCGCCGCCGCCGCCTCCCGGGCGACGCCGGGGGCCGACGCACTGC
AGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCTCCGACCCCGGCCCGGCTGGCACC
CCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTCGCTTCTCCCCCTTTCCCTCCTCC
CTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCCCCTTGACTCTCCCCTCCCAGCCC
TCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGCCGCTGCCGTCGCAGGGGGGGAGT
CGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCTTGGTCCCAGCTCTCCACGTCTCC
AACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGGGAAGGTGCAATGGATGAGCTTCA
TAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACTGGAAGTACGGGCAGTTGCAGTGT
TGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGTGACAAAGAATCAGAGTATTATTT
TGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTACCTTTGGAGATAATGATAAAATT
CAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCAGAACTCATGGAAATCAGTGAAGA
TAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGATGTAAAAAACAGATCTGTTTATAT
TAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTACTAAATATTCAGATGAGAAGAAC
ATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTTGTAGAGACCCCTGGCCAGAAGTA
CAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAACAAAATAAAGTGGAAGCTAAATT
AAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAAGAAAAGATTGGATGCTTGCTGAA
ATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGTGAAATAAAATGGATAGACTTCGT
CAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAAGATGCAAATAATGGTAACCTACA
ATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAAATAATAGAAGACCAACAAGAATC
CCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAGCCTGGGTCTGGTAAAGGAAAAGT
ACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGTGCAACTGGACCTGTGAAAAGAGC
AAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGACCAGTAGTTTAGTAAACCAATTTT
TTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAGGTCCACTTCAATGTCCACCTGTG
AGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGTATTGTTCTGTTTGTGTTATTTCA
GATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGTACAAACTAACTAATAAAATATAT

>91146_91146_5_TLK1-SSB_TLK1_chr2_171939290_ENST00000442919_SSB_chr2_170661983_ENST00000260956_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_6_TLK1-SSB_TLK1_chr2_171939290_ENST00000442919_SSB_chr2_170661983_ENST00000409333_length(transcript)=2271nt_BP=802nt
AACTGATGCAGAGGTTACCCCACCGCCTCAGCCGCCACCCACAGCCCGCCGCCGCCGCCTCCCGGGCGACGCCGGGGGCCGACGCACTGC
AGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCTCCGACCCCGGCCCGGCTGGCACC
CCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTCGCTTCTCCCCCTTTCCCTCCTCC
CTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCCCCTTGACTCTCCCCTCCCAGCCC
TCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGCCGCTGCCGTCGCAGGGGGGGAGT
CGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCTTGGTCCCAGCTCTCCACGTCTCC
AACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGGGAAGGTGCAATGGATGAGCTTCA
TAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACTGGAAGTACGGGCAGTTGCAGTGT
TGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGTGACAAAGAATCAGAGTATTATTT
TGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTACCTTTGGAGATAATGATAAAATT
CAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCAGAACTCATGGAAATCAGTGAAGA
TAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGATGTAAAAAACAGATCTGTTTATAT
TAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTACTAAATATTCAGATGAGAAGAAC
ATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTTGTAGAGACCCCTGGCCAGAAGTA
CAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAACAAAATAAAGTGGAAGCTAAATT
AAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAAGAAAAGATTGGATGCTTGCTGAA
ATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGTGAAATAAAATGGATAGACTTCGT
CAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAAGATGCAAATAATGGTAACCTACA
ATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAAATAATAGAAGACCAACAAGAATC
CCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAGCCTGGGTCTGGTAAAGGAAAAGT
ACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGTGCAACTGGACCTGTGAAAAGAGC
AAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGACCAGTAGTTTAGTAAACCAATTTT
TTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAGGTCCACTTCAATGTCCACCTGTG
AGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGTATTGTTCTGTTTGTGTTATTTCA
GATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGTACAAACTAACTAATAAAATATAT

>91146_91146_6_TLK1-SSB_TLK1_chr2_171939290_ENST00000442919_SSB_chr2_170661983_ENST00000409333_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_7_TLK1-SSB_TLK1_chr2_171939291_ENST00000360843_SSB_chr2_170661984_ENST00000260956_length(transcript)=2204nt_BP=735nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACT
GGAAGTACGGGCAGTTGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGT
GACAAAGAATCAGAGTATTATTTTGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTA
CCTTTGGAGATAATGATAAAATTCAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCA
GAACTCATGGAAATCAGTGAAGATAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGAT
GTAAAAAACAGATCTGTTTATATTAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTA
CTAAATATTCAGATGAGAAGAACATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTT
GTAGAGACCCCTGGCCAGAAGTACAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAA
CAAAATAAAGTGGAAGCTAAATTAAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAA
GAAAAGATTGGATGCTTGCTGAAATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGT
GAAATAAAATGGATAGACTTCGTCAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAA
GATGCAAATAATGGTAACCTACAATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAA
ATAATAGAAGACCAACAAGAATCCCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAG
CCTGGGTCTGGTAAAGGAAAAGTACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGT
GCAACTGGACCTGTGAAAAGAGCAAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGAC
CAGTAGTTTAGTAAACCAATTTTTTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAG
GTCCACTTCAATGTCCACCTGTGAGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGT
ATTGTTCTGTTTGTGTTATTTCAGATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGT

>91146_91146_7_TLK1-SSB_TLK1_chr2_171939291_ENST00000360843_SSB_chr2_170661984_ENST00000260956_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_8_TLK1-SSB_TLK1_chr2_171939291_ENST00000360843_SSB_chr2_170661984_ENST00000409333_length(transcript)=2204nt_BP=735nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACT
GGAAGTACGGGCAGTTGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGT
GACAAAGAATCAGAGTATTATTTTGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTA
CCTTTGGAGATAATGATAAAATTCAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCA
GAACTCATGGAAATCAGTGAAGATAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGAT
GTAAAAAACAGATCTGTTTATATTAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTA
CTAAATATTCAGATGAGAAGAACATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTT
GTAGAGACCCCTGGCCAGAAGTACAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAA
CAAAATAAAGTGGAAGCTAAATTAAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAA
GAAAAGATTGGATGCTTGCTGAAATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGT
GAAATAAAATGGATAGACTTCGTCAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAA
GATGCAAATAATGGTAACCTACAATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAA
ATAATAGAAGACCAACAAGAATCCCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAG
CCTGGGTCTGGTAAAGGAAAAGTACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGT
GCAACTGGACCTGTGAAAAGAGCAAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGAC
CAGTAGTTTAGTAAACCAATTTTTTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAG
GTCCACTTCAATGTCCACCTGTGAGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGT
ATTGTTCTGTTTGTGTTATTTCAGATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGT

>91146_91146_8_TLK1-SSB_TLK1_chr2_171939291_ENST00000360843_SSB_chr2_170661984_ENST00000409333_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_9_TLK1-SSB_TLK1_chr2_171939291_ENST00000431350_SSB_chr2_170661984_ENST00000260956_length(transcript)=2204nt_BP=735nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACT
GGAAGTACGGGCAGTTGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGT
GACAAAGAATCAGAGTATTATTTTGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTA
CCTTTGGAGATAATGATAAAATTCAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCA
GAACTCATGGAAATCAGTGAAGATAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGAT
GTAAAAAACAGATCTGTTTATATTAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTA
CTAAATATTCAGATGAGAAGAACATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTT
GTAGAGACCCCTGGCCAGAAGTACAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAA
CAAAATAAAGTGGAAGCTAAATTAAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAA
GAAAAGATTGGATGCTTGCTGAAATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGT
GAAATAAAATGGATAGACTTCGTCAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAA
GATGCAAATAATGGTAACCTACAATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAA
ATAATAGAAGACCAACAAGAATCCCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAG
CCTGGGTCTGGTAAAGGAAAAGTACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGT
GCAACTGGACCTGTGAAAAGAGCAAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGAC
CAGTAGTTTAGTAAACCAATTTTTTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAG
GTCCACTTCAATGTCCACCTGTGAGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGT
ATTGTTCTGTTTGTGTTATTTCAGATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGT

>91146_91146_9_TLK1-SSB_TLK1_chr2_171939291_ENST00000431350_SSB_chr2_170661984_ENST00000260956_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_10_TLK1-SSB_TLK1_chr2_171939291_ENST00000431350_SSB_chr2_170661984_ENST00000409333_length(transcript)=2204nt_BP=735nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGGTGCAATGGATGAGCTTCATAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACT
GGAAGTACGGGCAGTTGCAGTGTTGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGT
GACAAAGAATCAGAGTATTATTTTGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTA
CCTTTGGAGATAATGATAAAATTCAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCA
GAACTCATGGAAATCAGTGAAGATAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGAT
GTAAAAAACAGATCTGTTTATATTAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTA
CTAAATATTCAGATGAGAAGAACATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTT
GTAGAGACCCCTGGCCAGAAGTACAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAA
CAAAATAAAGTGGAAGCTAAATTAAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAA
GAAAAGATTGGATGCTTGCTGAAATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGT
GAAATAAAATGGATAGACTTCGTCAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAA
GATGCAAATAATGGTAACCTACAATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAA
ATAATAGAAGACCAACAAGAATCCCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAG
CCTGGGTCTGGTAAAGGAAAAGTACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGT
GCAACTGGACCTGTGAAAAGAGCAAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGAC
CAGTAGTTTAGTAAACCAATTTTTTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAG
GTCCACTTCAATGTCCACCTGTGAGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGT
ATTGTTCTGTTTGTGTTATTTCAGATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGT

>91146_91146_10_TLK1-SSB_TLK1_chr2_171939291_ENST00000431350_SSB_chr2_170661984_ENST00000409333_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_11_TLK1-SSB_TLK1_chr2_171939291_ENST00000442919_SSB_chr2_170661984_ENST00000260956_length(transcript)=2271nt_BP=802nt
AACTGATGCAGAGGTTACCCCACCGCCTCAGCCGCCACCCACAGCCCGCCGCCGCCGCCTCCCGGGCGACGCCGGGGGCCGACGCACTGC
AGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCTCCGACCCCGGCCCGGCTGGCACC
CCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTCGCTTCTCCCCCTTTCCCTCCTCC
CTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCCCCTTGACTCTCCCCTCCCAGCCC
TCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGCCGCTGCCGTCGCAGGGGGGGAGT
CGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCTTGGTCCCAGCTCTCCACGTCTCC
AACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGGGAAGGTGCAATGGATGAGCTTCA
TAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACTGGAAGTACGGGCAGTTGCAGTGT
TGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGTGACAAAGAATCAGAGTATTATTT
TGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTACCTTTGGAGATAATGATAAAATT
CAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCAGAACTCATGGAAATCAGTGAAGA
TAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGATGTAAAAAACAGATCTGTTTATAT
TAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTACTAAATATTCAGATGAGAAGAAC
ATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTTGTAGAGACCCCTGGCCAGAAGTA
CAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAACAAAATAAAGTGGAAGCTAAATT
AAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAAGAAAAGATTGGATGCTTGCTGAA
ATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGTGAAATAAAATGGATAGACTTCGT
CAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAAGATGCAAATAATGGTAACCTACA
ATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAAATAATAGAAGACCAACAAGAATC
CCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAGCCTGGGTCTGGTAAAGGAAAAGT
ACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGTGCAACTGGACCTGTGAAAAGAGC
AAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGACCAGTAGTTTAGTAAACCAATTTT
TTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAGGTCCACTTCAATGTCCACCTGTG
AGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGTATTGTTCTGTTTGTGTTATTTCA
GATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGTACAAACTAACTAATAAAATATAT

>91146_91146_11_TLK1-SSB_TLK1_chr2_171939291_ENST00000442919_SSB_chr2_170661984_ENST00000260956_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------
>91146_91146_12_TLK1-SSB_TLK1_chr2_171939291_ENST00000442919_SSB_chr2_170661984_ENST00000409333_length(transcript)=2271nt_BP=802nt
AACTGATGCAGAGGTTACCCCACCGCCTCAGCCGCCACCCACAGCCCGCCGCCGCCGCCTCCCGGGCGACGCCGGGGGCCGACGCACTGC
AGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCTCCGACCCCGGCCCGGCTGGCACC
CCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTCGCTTCTCCCCCTTTCCCTCCTCC
CTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCCCCTTGACTCTCCCCTCCCAGCCC
TCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGCCGCTGCCGTCGCAGGGGGGGAGT
CGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCTTGGTCCCAGCTCTCCACGTCTCC
AACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGGGAAGGTGCAATGGATGAGCTTCA
TAGTCTGGATCCAAGAAGGCAAGAGTTATTGGAAGCTAGATTTACTGGAGTTGCAAGTGGGAGCACTGGAAGTACGGGCAGTTGCAGTGT
TGGAGCTAAAGCCTCAACAAATAACGAAAGCTCTAATCACAGTTTTGGAAGCTTGGGATCTTTAAGTGACAAAGAATCAGAGTATTATTT
TGGCGACTTCAATTTGCCACGGGACAAGTTTCTAAAGGAACAGATAAAACTGGATGAAGGCTGGGTACCTTTGGAGATAATGATAAAATT
CAACAGGTTGAACCGTCTAACAACAGACTTTAATGTAATTGTGGAAGCATTGAGCAAATCCAAGGCAGAACTCATGGAAATCAGTGAAGA
TAAAACTAAAATCAGAAGGTCTCCAAGCAAACCCCTACCTGAAGTGACTGATGAGTATAAAAATGATGTAAAAAACAGATCTGTTTATAT
TAAAGGCTTCCCAACTGATGCAACTCTTGATGACATAAAAGAATGGTTAGAAGATAAAGGTCAAGTACTAAATATTCAGATGAGAAGAAC
ATTGCATAAAGCATTTAAGGGATCAATTTTTGTTGTGTTTGATAGCATTGAATCTGCTAAGAAATTTGTAGAGACCCCTGGCCAGAAGTA
CAAAGAAACAGACCTGCTAATACTTTTCAAGGACGATTACTTTGCCAAAAAAAATGAAGAAAGAAAACAAAATAAAGTGGAAGCTAAATT
AAGAGCTAAACAGGAGCAAGAAGCAAAACAAAAGTTAGAAGAAGATGCTGAAATGAAATCTCTAGAAGAAAAGATTGGATGCTTGCTGAA
ATTTTCGGGTGATTTAGATGATCAGACCTGTAGAGAAGATTTACACATACTTTTCTCAAATCATGGTGAAATAAAATGGATAGACTTCGT
CAGAGGAGCAAAAGAGGGGATAATTCTATTTAAAGAAAAAGCCAAGGAAGCATTGGGTAAAGCCAAAGATGCAAATAATGGTAACCTACA
ATTAAGGAACAAAGAAGTGACTTGGGAAGTACTAGAAGGAGAGGTGGAAAAAGAAGCACTGAAGAAAATAATAGAAGACCAACAAGAATC
CCTAAACAAATGGAAGTCAAAAGGTCGTAGATTTAAAGGAAAAGGAAAGGGTAATAAAGCTGCCCAGCCTGGGTCTGGTAAAGGAAAAGT
ACAGTTTCAGGGCAAGAAAACGAAATTTGCTAGTGATGATGAACATGATGAACATGATGAAAATGGTGCAACTGGACCTGTGAAAAGAGC
AAGAGAAGAAACAGACAAAGAAGAACCTGCATCCAAACAACAGAAAACAGAAAATGGTGCTGGAGACCAGTAGTTTAGTAAACCAATTTT
TTATTCATTTTAAATAGGTTTTAAACGACTTTTGTTTGCGGGGCTTTTAAAAGGAAAACCGAATTAGGTCCACTTCAATGTCCACCTGTG
AGAAAGGAAAAATTTTTTTGTTGTTTAACTTGTCTTTTTGTTATGCAAATGAGATTTCTTTGAATGTATTGTTCTGTTTGTGTTATTTCA
GATGATTCAAATATCAAAAGGAAGATTCTTCCATTAAATTGCCTTTGTAATATGAGAATGTATTAGTACAAACTAACTAATAAAATATAT

>91146_91146_12_TLK1-SSB_TLK1_chr2_171939291_ENST00000442919_SSB_chr2_170661984_ENST00000409333_length(amino acids)=497AA_BP=109
MMSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKAST
NNESSNHSFGSLGSLSDKESEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRR
SPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLL
ILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEG
IILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TLK1-SSB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TLK1-SSB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TLK1-SSB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource