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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TLK1-XPO7 (FusionGDB2 ID:91148)

Fusion Gene Summary for TLK1-XPO7

check button Fusion gene summary
Fusion gene informationFusion gene name: TLK1-XPO7
Fusion gene ID: 91148
HgeneTgene
Gene symbol

TLK1

XPO7

Gene ID

9874

23039

Gene nametousled like kinase 1exportin 7
SynonymsPKU-betaEXP7|RANBP16
Cytomap

2q31.1

8p21.3

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase tousled-like 1SNARE protein kinase SNAKserine threonine protein kinaseexportin-7RAN binding protein 16
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000360843, ENST00000431350, 
ENST00000442919, ENST00000434911, 
ENST00000486857, ENST00000521943, 
ENST00000433566, ENST00000518017, 
ENST00000252512, ENST00000434536, 
Fusion gene scores* DoF score13 X 15 X 6=11709 X 10 X 4=360
# samples 1811
** MAII scorelog2(18/1170*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TLK1 [Title/Abstract] AND XPO7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTLK1(172016800)-XPO7(21824368), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTLK1

GO:0001672

regulation of chromatin assembly or disassembly

12660173

HgeneTLK1

GO:0006468

protein phosphorylation

12660173

HgeneTLK1

GO:0006886

intracellular protein transport

10588641

HgeneTLK1

GO:0035556

intracellular signal transduction

12660173

TgeneXPO7

GO:0006611

protein export from nucleus

11024021


check buttonFusion gene breakpoints across TLK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across XPO7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8524-01ATLK1chr2

172016800

-XPO7chr8

21824368

+


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Fusion Gene ORF analysis for TLK1-XPO7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000360843ENST00000433566TLK1chr2

172016800

-XPO7chr8

21824368

+
5CDS-3UTRENST00000360843ENST00000518017TLK1chr2

172016800

-XPO7chr8

21824368

+
5CDS-3UTRENST00000431350ENST00000433566TLK1chr2

172016800

-XPO7chr8

21824368

+
5CDS-3UTRENST00000431350ENST00000518017TLK1chr2

172016800

-XPO7chr8

21824368

+
5UTR-3CDSENST00000442919ENST00000252512TLK1chr2

172016800

-XPO7chr8

21824368

+
5UTR-3CDSENST00000442919ENST00000434536TLK1chr2

172016800

-XPO7chr8

21824368

+
5UTR-3UTRENST00000442919ENST00000433566TLK1chr2

172016800

-XPO7chr8

21824368

+
5UTR-3UTRENST00000442919ENST00000518017TLK1chr2

172016800

-XPO7chr8

21824368

+
In-frameENST00000360843ENST00000252512TLK1chr2

172016800

-XPO7chr8

21824368

+
In-frameENST00000360843ENST00000434536TLK1chr2

172016800

-XPO7chr8

21824368

+
In-frameENST00000431350ENST00000252512TLK1chr2

172016800

-XPO7chr8

21824368

+
In-frameENST00000431350ENST00000434536TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3CDSENST00000434911ENST00000252512TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3CDSENST00000434911ENST00000434536TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3CDSENST00000486857ENST00000252512TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3CDSENST00000486857ENST00000434536TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3CDSENST00000521943ENST00000252512TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3CDSENST00000521943ENST00000434536TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3UTRENST00000434911ENST00000433566TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3UTRENST00000434911ENST00000518017TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3UTRENST00000486857ENST00000433566TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3UTRENST00000486857ENST00000518017TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3UTRENST00000521943ENST00000433566TLK1chr2

172016800

-XPO7chr8

21824368

+
intron-3UTRENST00000521943ENST00000518017TLK1chr2

172016800

-XPO7chr8

21824368

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360843TLK1chr2172016800-ENST00000434536XPO7chr821824368+531354454738161089
ENST00000360843TLK1chr2172016800-ENST00000252512XPO7chr821824368+528754454737891080
ENST00000431350TLK1chr2172016800-ENST00000434536XPO7chr821824368+531354454738161089
ENST00000431350TLK1chr2172016800-ENST00000252512XPO7chr821824368+528754454737891080

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360843ENST00000434536TLK1chr2172016800-XPO7chr821824368+0.000593010.99940705
ENST00000360843ENST00000252512TLK1chr2172016800-XPO7chr821824368+0.000589480.9994105
ENST00000431350ENST00000434536TLK1chr2172016800-XPO7chr821824368+0.000593010.99940705
ENST00000431350ENST00000252512TLK1chr2172016800-XPO7chr821824368+0.000589480.9994105

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Fusion Genomic Features for TLK1-XPO7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TLK1chr2172016799-XPO7chr821824367+9.49E-091
TLK1chr2172016799-XPO7chr821824367+9.49E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TLK1-XPO7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:172016800/chr8:21824368)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneXPO7chr2:172016800chr8:21824368ENST0000025251202830_9661088.0DomainImportin N-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTLK1chr2:172016800chr8:21824368ENST00000360843-122230_28146788.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000360843-122397_44546788.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000431350-121230_28146767.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000431350-121397_44546767.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000434911-119230_2810671.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000434911-119397_4450671.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000442919-121230_2810719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000442919-121397_4450719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000521943-121230_2810719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000521943-121397_4450719.0Coiled coilOntology_term=ECO:0000255
HgeneTLK1chr2:172016800chr8:21824368ENST00000360843-122456_73446788.0DomainProtein kinase
HgeneTLK1chr2:172016800chr8:21824368ENST00000431350-121456_73446767.0DomainProtein kinase
HgeneTLK1chr2:172016800chr8:21824368ENST00000434911-119456_7340671.0DomainProtein kinase
HgeneTLK1chr2:172016800chr8:21824368ENST00000442919-121456_7340719.0DomainProtein kinase
HgeneTLK1chr2:172016800chr8:21824368ENST00000521943-121456_7340719.0DomainProtein kinase
HgeneTLK1chr2:172016800chr8:21824368ENST00000360843-122462_47046788.0Nucleotide bindingATP
HgeneTLK1chr2:172016800chr8:21824368ENST00000431350-121462_47046767.0Nucleotide bindingATP
HgeneTLK1chr2:172016800chr8:21824368ENST00000434911-119462_4700671.0Nucleotide bindingATP
HgeneTLK1chr2:172016800chr8:21824368ENST00000442919-121462_4700719.0Nucleotide bindingATP
HgeneTLK1chr2:172016800chr8:21824368ENST00000521943-121462_4700719.0Nucleotide bindingATP


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Fusion Gene Sequence for TLK1-XPO7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91148_91148_1_TLK1-XPO7_TLK1_chr2_172016800_ENST00000360843_XPO7_chr8_21824368_ENST00000252512_length(transcript)=5287nt_BP=544nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGAGCCTGGCCCAACTAGAGAATCTGTGCAAACAGCTGTATGAAACCACAGACACAACCACTCGACTCCAGGCAGAGAAAGCCTTGGT
TGAATTTACCAACAGCCCTGATTGCCTGAGCAAGTGCCAGCTACTCCTCGAAAGAGGAAGTTCCTCTTACTCCCAGTTACTGGCAGCTAC
ATGCCTTACCAAGCTTGTATCACGCACAAACAACCCCCTACCATTGGAACAGCGAATAGATATTCGGAACTATGTGCTCAACTACCTTGC
CACTCGGCCGAAGTTGGCTACTTTCGTGACACAAGCACTTATTCAGTTATATGCCAGAATCACAAAACTGGGCTGGTTTGACTGTCAGAA
GGATGACTATGTCTTCAGAAATGCAATCACAGACGTCACAAGGTTTTTACAGGATAGTGTTGAATACTGCATCATTGGTGTCACAATTTT
ATCTCAGCTAACCAATGAAATTAATCAAGCAGACACCACCCATCCTTTAACCAAGCACAGAAAAATAGCCTCTTCTTTTCGCGATTCATC
ATTATTTGATATCTTCACACTTTCCTGCAATTTACTAAAACAGGCTTCAGGAAAGAATCTAAACTTGAATGATGAAAGTCAGCATGGCTT
GCTCATGCAACTGCTCAAGCTCACTCATAACTGCCTCAACTTTGACTTCATCGGCACTTCCACTGATGAGTCCTCAGACGACCTGTGTAC
AGTGCAGATTCCCACCAGCTGGAGATCAGCCTTCTTAGATTCTTCAACCTTGCAGCTGTTTTTTGACCTGTATCATTCCATCCCTCCTTC
ATTTTCACCTCTGGTATTATCCTGCTTGGTACAGATCGCTTCAGTCAGAAGATCCCTGTTTAACAATGCAGAGAGGGCCAAGTTTCTCTC
TCATCTTGTTGATGGTGTTAAACGAATACTGGAAAACCCACAGAGTTTATCAGACCCAAACAATTACCATGAGTTTTGCAGACTACTGGC
CCGATTGAAGAGTAACTATCAACTGGGAGAATTGGTAAAGGTGGAAAACTACCCTGAGGTCATCCGATTGATAGCCAACTTCACAGTGAC
CAGCCTACAGCACTGGGAATTTGCTCCAAATAGTGTGCACTATCTTCTGAGCCTGTGGCAGCGGCTGGCAGCCTCTGTGCCGTATGTCAA
AGCCACAGAGCCCCACATGCTGGAAACTTACACTCCTGAGGTCACCAAAGCCTACATCACATCCCGGTTGGAATCTGTGCACATCATACT
GAGAGATGGCCTGGAAGATCCCCTGGAGGATACGGGGCTGGTCCAGCAGCAGTTGGACCAGCTGTCCACCATTGGGCGTTGTGAATATGA
GAAGACGTGTGCACTCCTCGTGCAGTTGTTTGACCAGTCGGCCCAGTCGTACCAGGAGCTGCTACAGAGCGCCAGCGCAAGCCCAATGGA
CATTGCAGTGCAGGAGGGAAGGCTGACATGGCTGGTTTACATTATTGGAGCAGTGATCGGTGGCCGGGTTTCTTTTGCCAGCACTGATGA
GCAAGACGCCATGGATGGTGAGCTTGTCTGTCGGGTGCTCCAGCTGATGAACCTAACAGATTCTCGTTTGGCCCAGGCGGGTAATGAGAA
GCTAGAGTTGGCCATGCTGAGCTTTTTTGAACAGTTTCGTAAGATCTACATTGGGGACCAAGTGCAGAAATCCTCTAAGCTGTACCGCCG
ACTCTCAGAAGTTCTGGGCTTGAATGATGAGACCATGGTCCTAAGCGTCTTCATAGGAAAAATCATCACCAACTTGAAGTACTGGGGCCG
TTGTGAACCAATCACCTCCAAGACACTACAGCTTCTCAATGACCTGTCCATTGGGTACAGTAGCGTAAGGAAGCTAGTGAAGCTTAGTGC
GGTACAGTTCATGCTGAACAATCACACGAGCGAGCACTTTTCATTTTTGGGTATTAACAATCAGTCCAACCTGACAGACATGCGGTGTCG
GACTACCTTCTACACAGCACTTGGGCGTCTCCTCATGGTGGATTTAGGAGAGGATGAAGATCAGTATGAGCAGTTCATGCTGCCACTCAC
AGCAGCATTTGAGGCTGTGGCCCAGATGTTTAGCACCAATAGTTTCAACGAGCAGGAGGCAAAGCGAACTCTAGTTGGCCTAGTAAGAGA
CCTGAGAGGGATCGCTTTCGCTTTCAATGCCAAGACCAGCTTCATGATGCTCTTTGAATGGATATATCCATCCTATATGCCAATTCTCCA
ACGGGCAATTGAGCTCTGGTACCATGATCCAGCCTGTACTACACCTGTACTCAAGTTGATGGCTGAATTGGTTCATAATAGGTCCCAGCG
ACTCCAGTTTGATGTCTCTTCCCCCAATGGCATCTTACTCTTCCGAGAAACCAGCAAGATGATAACAATGTATGGCAATCGCATCCTGAC
ACTAGGAGAGGTCCCAAAGGATCAGGTCTATGCTCTGAAGCTCAAGGGCATCTCCATCTGCTTCTCCATGCTGAAGGCTGCTCTCAGTGG
GAGTTACGTCAATTTCGGAGTCTTTCGTCTCTATGGAGACGATGCCCTGGACAATGCTCTGCAGACCTTCATCAAGCTGCTCCTCTCTAT
TCCTCACAGTGATCTCTTGGATTACCCCAAGCTCAGCCAGTCTTATTATTCACTACTGGAAGTCCTGACCCAGGACCATATGAACTTTAT
TGCAAGCCTGGAACCTCACGTCATCATGTATATTCTCTCTTCCATTTCTGAAGGACTTACTGCACTTGACACCATGGTATGCACAGGCTG
CTGCTCCTGCCTGGACCACATTGTGACATACCTCTTCAAGCAGCTGTCACGTAGCACCAAGAAGAGGACCACACCCCTGAACCAGGAGAG
CGACCGCTTTCTGCACATCATGCAGCAGCATCCAGAGATGATCCAGCAGATGCTGTCCACGGTGCTGAACATCATCATCTTTGAAGACTG
TAGGAACCAGTGGTCTATGTCCCGACCACTACTTGGCTTGATATTGCTTAATGAAAAGTATTTTTCTGACCTAAGAAACAGTATTGTGAA
CAGCCAGCCACCGGAGAAGCAGCAGGCCATGCACCTGTGTTTTGAGAACCTGATGGAAGGCATCGAGCGAAATCTTCTTACGAAAAACAG
AGACAGGTTCACCCAGAACCTGTCAGCATTCCGTCGAGAAGTCAACGACTCAATGAAGAATTCCACTTATGGCGTGAATAGCAATGACAT
GATGAGCTGACACCTCCTTGGACTCTACCTGTACAGAGCAGCGTCCCTTTGGTTTGGCCCAGAGGGGCGAACAATTGCAAGGGAGAGGGC
CTGGCTGATCCTGGCTCTTTTCTCCAGGGGTGTGGGGAAAATGGCAAAGGTCAACTAGCTGCTTCCCCAGGGAATAGGGGTGTGAGTACA
CTCACTAGGGGGCAGGGCGCTGCTGGTTCCTGGGGGACTGGGTGGGAAGGGTGGTGGGAGGAGATAAGAGATACAAACTGAGACTCCAGC
CTCTCCTCCTGGGGCCACCCAAGTGGGGAGAACCCCTAGTGTCCTGCCACAACCTGCCTTGTATAAACATGTACATTTTTTCATAACATT
TTGAACAAGGTTTATATTGACTCAAGTTTAAAAACAAAAAGTGTGACTGAAAAATTTTTACAGAGTCTAGTGCACCAATGCTGATGTGAG
GGGTTGTGTATGCGAGTGAAGAAAATGTGTATTCTGGTGGCCTGAAGCTTTACTGGACAAGGATGTGTGAGAGTGCAGAGATATATTTAG
TGACACAGTAGAGAGGCAAAAAAAAAGCTAAAATTCCAAATGTATATTTTTTCGTATTGCCCTGTCCTCACCCAGAAATGATCAATTCCT
GTTACTGTATTAACCCTTGTTATTAGGAACTCTAAGCCATGCCAGAACACCGTCCCTCCCCTTGGACCGTGTAGATTCTGCCCTGGGTCC
CTAGCCCCTTGCAGTGATAAATAACTCCAGCTAAAAGTGTTTGGTGTTCTTATCTCCACCCTCTTTCCTACTTTGCTTACCCTCATCCTC
AGACAGATGCCTCTTGCTTTTAAAAGTTGGATTTAACGACGTGTTGTAGGGTTCTTGGTCTGTGTGAAGGCAGAGACCAGAGAGAAGGAA
GTGAGCCCACTGCTCTCCTGGGAGCAATGTGGGTGAGTCCACCAGAGGCCCTGCTGTGTGTGGCCAATAAATTTTAGTCTTCCCCAGCCC
TCGAGGCAGTGTGTGTGGATGTATGCGTGTGGATATTTATATATGTACCCTGCACTCATGAATGTATGAACTGGAGGAAGTTACTACAGT
GGAAGGGTTCTTAATAACAAGGTCTACCTAGCATGAAGTATTTAACATTCTCCCATCCCTTAAAAAATATACATTTTTATAAAATGAAAA
CCATAATAAATGTTTTGAATATTAAAAAAAATAATAACCTACAGAGGAAAATTAATGGAGACAGCTATTTGCCTTGTACTTTTTCCACAA
TTGTTGCTGCTAGTTGTACACATCTCTAGTTCAGCTCTTGCCCACGGGACACTCATCAATTAGGTTTTATTTTTATTTCTTTCCTCTACC
CCCAGAAACAAGCCTGTTAATTTTTTTTCCTTCTCCTCTGGCGACTGTGTGATGAATCCTTTCTTGCGTGATCAGGTTGCGGATAGACTT

>91148_91148_1_TLK1-XPO7_TLK1_chr2_172016800_ENST00000360843_XPO7_chr8_21824368_ENST00000252512_length(amino acids)=1080AA_BP=1
MAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATR
PKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLF
DIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFS
PLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIANFTVTSL
QHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKT
CALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLE
LAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQ
FMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLVGLVRDLR
GIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLG
EVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIAS
LEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNQESDRFLHIMQQHPEMIQQMLSTVLNIIIFEDCRN
QWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVNSNDMMS

--------------------------------------------------------------
>91148_91148_2_TLK1-XPO7_TLK1_chr2_172016800_ENST00000360843_XPO7_chr8_21824368_ENST00000434536_length(transcript)=5313nt_BP=544nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGAGCCTGGCCCAACTAGAGAATCTGTGCAAACAGCTGTATGAAACCACAGACACAACCACTCGACTCCAGGCAGAGAAAGCCTTGGT
TGAATTTACCAACAGCCCTGATTGCCTGAGCAAGTGCCAGCTACTCCTCGAAAGAGGAAGTTCCTCTTACTCCCAGTTACTGGCAGCTAC
ATGCCTTACCAAGCTTGTATCACGCACAAACAACCCCCTACCATTGGAACAGCGAATAGATATTCGGAACTATGTGCTCAACTACCTTGC
CACTCGGCCGAAGTTGGCTACTTTCGTGACACAAGCACTTATTCAGTTATATGCCAGAATCACAAAACTGGGCTGGTTTGACTGTCAGAA
GGATGACTATGTCTTCAGAAATGCAATCACAGACGTCACAAGGTTTTTACAGGATAGTGTTGAATACTGCATCATTGGTGTCACAATTTT
ATCTCAGCTAACCAATGAAATTAATCAAGTAAGTGCTACAGCCTTCCTCATTGAAGCAGACACCACCCATCCTTTAACCAAGCACAGAAA
AATAGCCTCTTCTTTTCGCGATTCATCATTATTTGATATCTTCACACTTTCCTGCAATTTACTAAAACAGGCTTCAGGAAAGAATCTAAA
CTTGAATGATGAAAGTCAGCATGGCTTGCTCATGCAACTGCTCAAGCTCACTCATAACTGCCTCAACTTTGACTTCATCGGCACTTCCAC
TGATGAGTCCTCAGACGACCTGTGTACAGTGCAGATTCCCACCAGCTGGAGATCAGCCTTCTTAGATTCTTCAACCTTGCAGCTGTTTTT
TGACCTGTATCATTCCATCCCTCCTTCATTTTCACCTCTGGTATTATCCTGCTTGGTACAGATCGCTTCAGTCAGAAGATCCCTGTTTAA
CAATGCAGAGAGGGCCAAGTTTCTCTCTCATCTTGTTGATGGTGTTAAACGAATACTGGAAAACCCACAGAGTTTATCAGACCCAAACAA
TTACCATGAGTTTTGCAGACTACTGGCCCGATTGAAGAGTAACTATCAACTGGGAGAATTGGTAAAGGTGGAAAACTACCCTGAGGTCAT
CCGATTGATAGCCAACTTCACAGTGACCAGCCTACAGCACTGGGAATTTGCTCCAAATAGTGTGCACTATCTTCTGAGCCTGTGGCAGCG
GCTGGCAGCCTCTGTGCCGTATGTCAAAGCCACAGAGCCCCACATGCTGGAAACTTACACTCCTGAGGTCACCAAAGCCTACATCACATC
CCGGTTGGAATCTGTGCACATCATACTGAGAGATGGCCTGGAAGATCCCCTGGAGGATACGGGGCTGGTCCAGCAGCAGTTGGACCAGCT
GTCCACCATTGGGCGTTGTGAATATGAGAAGACGTGTGCACTCCTCGTGCAGTTGTTTGACCAGTCGGCCCAGTCGTACCAGGAGCTGCT
ACAGAGCGCCAGCGCAAGCCCAATGGACATTGCAGTGCAGGAGGGAAGGCTGACATGGCTGGTTTACATTATTGGAGCAGTGATCGGTGG
CCGGGTTTCTTTTGCCAGCACTGATGAGCAAGACGCCATGGATGGTGAGCTTGTCTGTCGGGTGCTCCAGCTGATGAACCTAACAGATTC
TCGTTTGGCCCAGGCGGGTAATGAGAAGCTAGAGTTGGCCATGCTGAGCTTTTTTGAACAGTTTCGTAAGATCTACATTGGGGACCAAGT
GCAGAAATCCTCTAAGCTGTACCGCCGACTCTCAGAAGTTCTGGGCTTGAATGATGAGACCATGGTCCTAAGCGTCTTCATAGGAAAAAT
CATCACCAACTTGAAGTACTGGGGCCGTTGTGAACCAATCACCTCCAAGACACTACAGCTTCTCAATGACCTGTCCATTGGGTACAGTAG
CGTAAGGAAGCTAGTGAAGCTTAGTGCGGTACAGTTCATGCTGAACAATCACACGAGCGAGCACTTTTCATTTTTGGGTATTAACAATCA
GTCCAACCTGACAGACATGCGGTGTCGGACTACCTTCTACACAGCACTTGGGCGTCTCCTCATGGTGGATTTAGGAGAGGATGAAGATCA
GTATGAGCAGTTCATGCTGCCACTCACAGCAGCATTTGAGGCTGTGGCCCAGATGTTTAGCACCAATAGTTTCAACGAGCAGGAGGCAAA
GCGAACTCTAGTTGGCCTAGTAAGAGACCTGAGAGGGATCGCTTTCGCTTTCAATGCCAAGACCAGCTTCATGATGCTCTTTGAATGGAT
ATATCCATCCTATATGCCAATTCTCCAACGGGCAATTGAGCTCTGGTACCATGATCCAGCCTGTACTACACCTGTACTCAAGTTGATGGC
TGAATTGGTTCATAATAGGTCCCAGCGACTCCAGTTTGATGTCTCTTCCCCCAATGGCATCTTACTCTTCCGAGAAACCAGCAAGATGAT
AACAATGTATGGCAATCGCATCCTGACACTAGGAGAGGTCCCAAAGGATCAGGTCTATGCTCTGAAGCTCAAGGGCATCTCCATCTGCTT
CTCCATGCTGAAGGCTGCTCTCAGTGGGAGTTACGTCAATTTCGGAGTCTTTCGTCTCTATGGAGACGATGCCCTGGACAATGCTCTGCA
GACCTTCATCAAGCTGCTCCTCTCTATTCCTCACAGTGATCTCTTGGATTACCCCAAGCTCAGCCAGTCTTATTATTCACTACTGGAAGT
CCTGACCCAGGACCATATGAACTTTATTGCAAGCCTGGAACCTCACGTCATCATGTATATTCTCTCTTCCATTTCTGAAGGACTTACTGC
ACTTGACACCATGGTATGCACAGGCTGCTGCTCCTGCCTGGACCACATTGTGACATACCTCTTCAAGCAGCTGTCACGTAGCACCAAGAA
GAGGACCACACCCCTGAACCAGGAGAGCGACCGCTTTCTGCACATCATGCAGCAGCATCCAGAGATGATCCAGCAGATGCTGTCCACGGT
GCTGAACATCATCATCTTTGAAGACTGTAGGAACCAGTGGTCTATGTCCCGACCACTACTTGGCTTGATATTGCTTAATGAAAAGTATTT
TTCTGACCTAAGAAACAGTATTGTGAACAGCCAGCCACCGGAGAAGCAGCAGGCCATGCACCTGTGTTTTGAGAACCTGATGGAAGGCAT
CGAGCGAAATCTTCTTACGAAAAACAGAGACAGGTTCACCCAGAACCTGTCAGCATTCCGTCGAGAAGTCAACGACTCAATGAAGAATTC
CACTTATGGCGTGAATAGCAATGACATGATGAGCTGACACCTCCTTGGACTCTACCTGTACAGAGCAGCGTCCCTTTGGTTTGGCCCAGA
GGGGCGAACAATTGCAAGGGAGAGGGCCTGGCTGATCCTGGCTCTTTTCTCCAGGGGTGTGGGGAAAATGGCAAAGGTCAACTAGCTGCT
TCCCCAGGGAATAGGGGTGTGAGTACACTCACTAGGGGGCAGGGCGCTGCTGGTTCCTGGGGGACTGGGTGGGAAGGGTGGTGGGAGGAG
ATAAGAGATACAAACTGAGACTCCAGCCTCTCCTCCTGGGGCCACCCAAGTGGGGAGAACCCCTAGTGTCCTGCCACAACCTGCCTTGTA
TAAACATGTACATTTTTTCATAACATTTTGAACAAGGTTTATATTGACTCAAGTTTAAAAACAAAAAGTGTGACTGAAAAATTTTTACAG
AGTCTAGTGCACCAATGCTGATGTGAGGGGTTGTGTATGCGAGTGAAGAAAATGTGTATTCTGGTGGCCTGAAGCTTTACTGGACAAGGA
TGTGTGAGAGTGCAGAGATATATTTAGTGACACAGTAGAGAGGCAAAAAAAAAGCTAAAATTCCAAATGTATATTTTTTCGTATTGCCCT
GTCCTCACCCAGAAATGATCAATTCCTGTTACTGTATTAACCCTTGTTATTAGGAACTCTAAGCCATGCCAGAACACCGTCCCTCCCCTT
GGACCGTGTAGATTCTGCCCTGGGTCCCTAGCCCCTTGCAGTGATAAATAACTCCAGCTAAAAGTGTTTGGTGTTCTTATCTCCACCCTC
TTTCCTACTTTGCTTACCCTCATCCTCAGACAGATGCCTCTTGCTTTTAAAAGTTGGATTTAACGACGTGTTGTAGGGTTCTTGGTCTGT
GTGAAGGCAGAGACCAGAGAGAAGGAAGTGAGCCCACTGCTCTCCTGGGAGCAATGTGGGTGAGTCCACCAGAGGCCCTGCTGTGTGTGG
CCAATAAATTTTAGTCTTCCCCAGCCCTCGAGGCAGTGTGTGTGGATGTATGCGTGTGGATATTTATATATGTACCCTGCACTCATGAAT
GTATGAACTGGAGGAAGTTACTACAGTGGAAGGGTTCTTAATAACAAGGTCTACCTAGCATGAAGTATTTAACATTCTCCCATCCCTTAA
AAAATATACATTTTTATAAAATGAAAACCATAATAAATGTTTTGAATATTAAAAAAAATAATAACCTACAGAGGAAAATTAATGGAGACA
GCTATTTGCCTTGTACTTTTTCCACAATTGTTGCTGCTAGTTGTACACATCTCTAGTTCAGCTCTTGCCCACGGGACACTCATCAATTAG
GTTTTATTTTTATTTCTTTCCTCTACCCCCAGAAACAAGCCTGTTAATTTTTTTTCCTTCTCCTCTGGCGACTGTGTGATGAATCCTTTC
TTGCGTGATCAGGTTGCGGATAGACTTGTAAGGGTGTTTGCTGCATACAGTGTAAGCATTGTGACCGCCAATAAACTTCAATGGTTTCTA

>91148_91148_2_TLK1-XPO7_TLK1_chr2_172016800_ENST00000360843_XPO7_chr8_21824368_ENST00000434536_length(amino acids)=1089AA_BP=1
MAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATR
PKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQVSATAFLIEADTTHPLTKHRKIA
SSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDL
YHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRL
IANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLST
IGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRL
AQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVR
KLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRT
LVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITM
YGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLT
QDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNQESDRFLHIMQQHPEMIQQMLSTVLN
IIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTY

--------------------------------------------------------------
>91148_91148_3_TLK1-XPO7_TLK1_chr2_172016800_ENST00000431350_XPO7_chr8_21824368_ENST00000252512_length(transcript)=5287nt_BP=544nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGAGCCTGGCCCAACTAGAGAATCTGTGCAAACAGCTGTATGAAACCACAGACACAACCACTCGACTCCAGGCAGAGAAAGCCTTGGT
TGAATTTACCAACAGCCCTGATTGCCTGAGCAAGTGCCAGCTACTCCTCGAAAGAGGAAGTTCCTCTTACTCCCAGTTACTGGCAGCTAC
ATGCCTTACCAAGCTTGTATCACGCACAAACAACCCCCTACCATTGGAACAGCGAATAGATATTCGGAACTATGTGCTCAACTACCTTGC
CACTCGGCCGAAGTTGGCTACTTTCGTGACACAAGCACTTATTCAGTTATATGCCAGAATCACAAAACTGGGCTGGTTTGACTGTCAGAA
GGATGACTATGTCTTCAGAAATGCAATCACAGACGTCACAAGGTTTTTACAGGATAGTGTTGAATACTGCATCATTGGTGTCACAATTTT
ATCTCAGCTAACCAATGAAATTAATCAAGCAGACACCACCCATCCTTTAACCAAGCACAGAAAAATAGCCTCTTCTTTTCGCGATTCATC
ATTATTTGATATCTTCACACTTTCCTGCAATTTACTAAAACAGGCTTCAGGAAAGAATCTAAACTTGAATGATGAAAGTCAGCATGGCTT
GCTCATGCAACTGCTCAAGCTCACTCATAACTGCCTCAACTTTGACTTCATCGGCACTTCCACTGATGAGTCCTCAGACGACCTGTGTAC
AGTGCAGATTCCCACCAGCTGGAGATCAGCCTTCTTAGATTCTTCAACCTTGCAGCTGTTTTTTGACCTGTATCATTCCATCCCTCCTTC
ATTTTCACCTCTGGTATTATCCTGCTTGGTACAGATCGCTTCAGTCAGAAGATCCCTGTTTAACAATGCAGAGAGGGCCAAGTTTCTCTC
TCATCTTGTTGATGGTGTTAAACGAATACTGGAAAACCCACAGAGTTTATCAGACCCAAACAATTACCATGAGTTTTGCAGACTACTGGC
CCGATTGAAGAGTAACTATCAACTGGGAGAATTGGTAAAGGTGGAAAACTACCCTGAGGTCATCCGATTGATAGCCAACTTCACAGTGAC
CAGCCTACAGCACTGGGAATTTGCTCCAAATAGTGTGCACTATCTTCTGAGCCTGTGGCAGCGGCTGGCAGCCTCTGTGCCGTATGTCAA
AGCCACAGAGCCCCACATGCTGGAAACTTACACTCCTGAGGTCACCAAAGCCTACATCACATCCCGGTTGGAATCTGTGCACATCATACT
GAGAGATGGCCTGGAAGATCCCCTGGAGGATACGGGGCTGGTCCAGCAGCAGTTGGACCAGCTGTCCACCATTGGGCGTTGTGAATATGA
GAAGACGTGTGCACTCCTCGTGCAGTTGTTTGACCAGTCGGCCCAGTCGTACCAGGAGCTGCTACAGAGCGCCAGCGCAAGCCCAATGGA
CATTGCAGTGCAGGAGGGAAGGCTGACATGGCTGGTTTACATTATTGGAGCAGTGATCGGTGGCCGGGTTTCTTTTGCCAGCACTGATGA
GCAAGACGCCATGGATGGTGAGCTTGTCTGTCGGGTGCTCCAGCTGATGAACCTAACAGATTCTCGTTTGGCCCAGGCGGGTAATGAGAA
GCTAGAGTTGGCCATGCTGAGCTTTTTTGAACAGTTTCGTAAGATCTACATTGGGGACCAAGTGCAGAAATCCTCTAAGCTGTACCGCCG
ACTCTCAGAAGTTCTGGGCTTGAATGATGAGACCATGGTCCTAAGCGTCTTCATAGGAAAAATCATCACCAACTTGAAGTACTGGGGCCG
TTGTGAACCAATCACCTCCAAGACACTACAGCTTCTCAATGACCTGTCCATTGGGTACAGTAGCGTAAGGAAGCTAGTGAAGCTTAGTGC
GGTACAGTTCATGCTGAACAATCACACGAGCGAGCACTTTTCATTTTTGGGTATTAACAATCAGTCCAACCTGACAGACATGCGGTGTCG
GACTACCTTCTACACAGCACTTGGGCGTCTCCTCATGGTGGATTTAGGAGAGGATGAAGATCAGTATGAGCAGTTCATGCTGCCACTCAC
AGCAGCATTTGAGGCTGTGGCCCAGATGTTTAGCACCAATAGTTTCAACGAGCAGGAGGCAAAGCGAACTCTAGTTGGCCTAGTAAGAGA
CCTGAGAGGGATCGCTTTCGCTTTCAATGCCAAGACCAGCTTCATGATGCTCTTTGAATGGATATATCCATCCTATATGCCAATTCTCCA
ACGGGCAATTGAGCTCTGGTACCATGATCCAGCCTGTACTACACCTGTACTCAAGTTGATGGCTGAATTGGTTCATAATAGGTCCCAGCG
ACTCCAGTTTGATGTCTCTTCCCCCAATGGCATCTTACTCTTCCGAGAAACCAGCAAGATGATAACAATGTATGGCAATCGCATCCTGAC
ACTAGGAGAGGTCCCAAAGGATCAGGTCTATGCTCTGAAGCTCAAGGGCATCTCCATCTGCTTCTCCATGCTGAAGGCTGCTCTCAGTGG
GAGTTACGTCAATTTCGGAGTCTTTCGTCTCTATGGAGACGATGCCCTGGACAATGCTCTGCAGACCTTCATCAAGCTGCTCCTCTCTAT
TCCTCACAGTGATCTCTTGGATTACCCCAAGCTCAGCCAGTCTTATTATTCACTACTGGAAGTCCTGACCCAGGACCATATGAACTTTAT
TGCAAGCCTGGAACCTCACGTCATCATGTATATTCTCTCTTCCATTTCTGAAGGACTTACTGCACTTGACACCATGGTATGCACAGGCTG
CTGCTCCTGCCTGGACCACATTGTGACATACCTCTTCAAGCAGCTGTCACGTAGCACCAAGAAGAGGACCACACCCCTGAACCAGGAGAG
CGACCGCTTTCTGCACATCATGCAGCAGCATCCAGAGATGATCCAGCAGATGCTGTCCACGGTGCTGAACATCATCATCTTTGAAGACTG
TAGGAACCAGTGGTCTATGTCCCGACCACTACTTGGCTTGATATTGCTTAATGAAAAGTATTTTTCTGACCTAAGAAACAGTATTGTGAA
CAGCCAGCCACCGGAGAAGCAGCAGGCCATGCACCTGTGTTTTGAGAACCTGATGGAAGGCATCGAGCGAAATCTTCTTACGAAAAACAG
AGACAGGTTCACCCAGAACCTGTCAGCATTCCGTCGAGAAGTCAACGACTCAATGAAGAATTCCACTTATGGCGTGAATAGCAATGACAT
GATGAGCTGACACCTCCTTGGACTCTACCTGTACAGAGCAGCGTCCCTTTGGTTTGGCCCAGAGGGGCGAACAATTGCAAGGGAGAGGGC
CTGGCTGATCCTGGCTCTTTTCTCCAGGGGTGTGGGGAAAATGGCAAAGGTCAACTAGCTGCTTCCCCAGGGAATAGGGGTGTGAGTACA
CTCACTAGGGGGCAGGGCGCTGCTGGTTCCTGGGGGACTGGGTGGGAAGGGTGGTGGGAGGAGATAAGAGATACAAACTGAGACTCCAGC
CTCTCCTCCTGGGGCCACCCAAGTGGGGAGAACCCCTAGTGTCCTGCCACAACCTGCCTTGTATAAACATGTACATTTTTTCATAACATT
TTGAACAAGGTTTATATTGACTCAAGTTTAAAAACAAAAAGTGTGACTGAAAAATTTTTACAGAGTCTAGTGCACCAATGCTGATGTGAG
GGGTTGTGTATGCGAGTGAAGAAAATGTGTATTCTGGTGGCCTGAAGCTTTACTGGACAAGGATGTGTGAGAGTGCAGAGATATATTTAG
TGACACAGTAGAGAGGCAAAAAAAAAGCTAAAATTCCAAATGTATATTTTTTCGTATTGCCCTGTCCTCACCCAGAAATGATCAATTCCT
GTTACTGTATTAACCCTTGTTATTAGGAACTCTAAGCCATGCCAGAACACCGTCCCTCCCCTTGGACCGTGTAGATTCTGCCCTGGGTCC
CTAGCCCCTTGCAGTGATAAATAACTCCAGCTAAAAGTGTTTGGTGTTCTTATCTCCACCCTCTTTCCTACTTTGCTTACCCTCATCCTC
AGACAGATGCCTCTTGCTTTTAAAAGTTGGATTTAACGACGTGTTGTAGGGTTCTTGGTCTGTGTGAAGGCAGAGACCAGAGAGAAGGAA
GTGAGCCCACTGCTCTCCTGGGAGCAATGTGGGTGAGTCCACCAGAGGCCCTGCTGTGTGTGGCCAATAAATTTTAGTCTTCCCCAGCCC
TCGAGGCAGTGTGTGTGGATGTATGCGTGTGGATATTTATATATGTACCCTGCACTCATGAATGTATGAACTGGAGGAAGTTACTACAGT
GGAAGGGTTCTTAATAACAAGGTCTACCTAGCATGAAGTATTTAACATTCTCCCATCCCTTAAAAAATATACATTTTTATAAAATGAAAA
CCATAATAAATGTTTTGAATATTAAAAAAAATAATAACCTACAGAGGAAAATTAATGGAGACAGCTATTTGCCTTGTACTTTTTCCACAA
TTGTTGCTGCTAGTTGTACACATCTCTAGTTCAGCTCTTGCCCACGGGACACTCATCAATTAGGTTTTATTTTTATTTCTTTCCTCTACC
CCCAGAAACAAGCCTGTTAATTTTTTTTCCTTCTCCTCTGGCGACTGTGTGATGAATCCTTTCTTGCGTGATCAGGTTGCGGATAGACTT

>91148_91148_3_TLK1-XPO7_TLK1_chr2_172016800_ENST00000431350_XPO7_chr8_21824368_ENST00000252512_length(amino acids)=1080AA_BP=1
MAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATR
PKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLF
DIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFS
PLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRLIANFTVTSL
QHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKT
CALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLE
LAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQ
FMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLVGLVRDLR
GIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLG
EVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIAS
LEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNQESDRFLHIMQQHPEMIQQMLSTVLNIIIFEDCRN
QWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVNSNDMMS

--------------------------------------------------------------
>91148_91148_4_TLK1-XPO7_TLK1_chr2_172016800_ENST00000431350_XPO7_chr8_21824368_ENST00000434536_length(transcript)=5313nt_BP=544nt
GACGCCGGGGGCCGACGCACTGCAGAGGTGCCGGCAGGTTCCGCCCGCGGAAGTGTCCTCGGCCGGCGCAGCCCGCGCTCCGCCCGCGCT
CCGACCCCGGCCCGGCTGGCACCCCCTCGACGCCTCCGCCGCCGCGCTCCTTTCCTCCTCCTCTCCTCTGGCGCGCCCGCTCGCTCCCTC
GCTTCTCCCCCTTTCCCTCCTCCCTGTCCCCTCTCCTTCCCTCACCTCTTTCCTCCCCACCTCCCCTCTTCTCGGTTTCCTCCCCCATCC
CCTTGACTCTCCCCTCCCAGCCCTCGCTCTCTCGCTCGCCCTCAGCGCGGCCCCCGCCATGACGGAGGCGGGTGCCGGTGCCGTTGCCGC
CGCTGCCGTCGCAGGGGGGGAGTCGGGTTCCCAGAAAGTAGCTTGATGAGTGTCCAAAGTAGCAGTGGAAGTTTGGAGGGGCCGCCATCT
TGGTCCCAGCTCTCCACGTCTCCAACCCCGGGCTCGGCGGCGGCGGCCAGGTCCCTGCTGAATCACACGCCGCCATCCGGGAGGCCCAGG
GAAGAGCCTGGCCCAACTAGAGAATCTGTGCAAACAGCTGTATGAAACCACAGACACAACCACTCGACTCCAGGCAGAGAAAGCCTTGGT
TGAATTTACCAACAGCCCTGATTGCCTGAGCAAGTGCCAGCTACTCCTCGAAAGAGGAAGTTCCTCTTACTCCCAGTTACTGGCAGCTAC
ATGCCTTACCAAGCTTGTATCACGCACAAACAACCCCCTACCATTGGAACAGCGAATAGATATTCGGAACTATGTGCTCAACTACCTTGC
CACTCGGCCGAAGTTGGCTACTTTCGTGACACAAGCACTTATTCAGTTATATGCCAGAATCACAAAACTGGGCTGGTTTGACTGTCAGAA
GGATGACTATGTCTTCAGAAATGCAATCACAGACGTCACAAGGTTTTTACAGGATAGTGTTGAATACTGCATCATTGGTGTCACAATTTT
ATCTCAGCTAACCAATGAAATTAATCAAGTAAGTGCTACAGCCTTCCTCATTGAAGCAGACACCACCCATCCTTTAACCAAGCACAGAAA
AATAGCCTCTTCTTTTCGCGATTCATCATTATTTGATATCTTCACACTTTCCTGCAATTTACTAAAACAGGCTTCAGGAAAGAATCTAAA
CTTGAATGATGAAAGTCAGCATGGCTTGCTCATGCAACTGCTCAAGCTCACTCATAACTGCCTCAACTTTGACTTCATCGGCACTTCCAC
TGATGAGTCCTCAGACGACCTGTGTACAGTGCAGATTCCCACCAGCTGGAGATCAGCCTTCTTAGATTCTTCAACCTTGCAGCTGTTTTT
TGACCTGTATCATTCCATCCCTCCTTCATTTTCACCTCTGGTATTATCCTGCTTGGTACAGATCGCTTCAGTCAGAAGATCCCTGTTTAA
CAATGCAGAGAGGGCCAAGTTTCTCTCTCATCTTGTTGATGGTGTTAAACGAATACTGGAAAACCCACAGAGTTTATCAGACCCAAACAA
TTACCATGAGTTTTGCAGACTACTGGCCCGATTGAAGAGTAACTATCAACTGGGAGAATTGGTAAAGGTGGAAAACTACCCTGAGGTCAT
CCGATTGATAGCCAACTTCACAGTGACCAGCCTACAGCACTGGGAATTTGCTCCAAATAGTGTGCACTATCTTCTGAGCCTGTGGCAGCG
GCTGGCAGCCTCTGTGCCGTATGTCAAAGCCACAGAGCCCCACATGCTGGAAACTTACACTCCTGAGGTCACCAAAGCCTACATCACATC
CCGGTTGGAATCTGTGCACATCATACTGAGAGATGGCCTGGAAGATCCCCTGGAGGATACGGGGCTGGTCCAGCAGCAGTTGGACCAGCT
GTCCACCATTGGGCGTTGTGAATATGAGAAGACGTGTGCACTCCTCGTGCAGTTGTTTGACCAGTCGGCCCAGTCGTACCAGGAGCTGCT
ACAGAGCGCCAGCGCAAGCCCAATGGACATTGCAGTGCAGGAGGGAAGGCTGACATGGCTGGTTTACATTATTGGAGCAGTGATCGGTGG
CCGGGTTTCTTTTGCCAGCACTGATGAGCAAGACGCCATGGATGGTGAGCTTGTCTGTCGGGTGCTCCAGCTGATGAACCTAACAGATTC
TCGTTTGGCCCAGGCGGGTAATGAGAAGCTAGAGTTGGCCATGCTGAGCTTTTTTGAACAGTTTCGTAAGATCTACATTGGGGACCAAGT
GCAGAAATCCTCTAAGCTGTACCGCCGACTCTCAGAAGTTCTGGGCTTGAATGATGAGACCATGGTCCTAAGCGTCTTCATAGGAAAAAT
CATCACCAACTTGAAGTACTGGGGCCGTTGTGAACCAATCACCTCCAAGACACTACAGCTTCTCAATGACCTGTCCATTGGGTACAGTAG
CGTAAGGAAGCTAGTGAAGCTTAGTGCGGTACAGTTCATGCTGAACAATCACACGAGCGAGCACTTTTCATTTTTGGGTATTAACAATCA
GTCCAACCTGACAGACATGCGGTGTCGGACTACCTTCTACACAGCACTTGGGCGTCTCCTCATGGTGGATTTAGGAGAGGATGAAGATCA
GTATGAGCAGTTCATGCTGCCACTCACAGCAGCATTTGAGGCTGTGGCCCAGATGTTTAGCACCAATAGTTTCAACGAGCAGGAGGCAAA
GCGAACTCTAGTTGGCCTAGTAAGAGACCTGAGAGGGATCGCTTTCGCTTTCAATGCCAAGACCAGCTTCATGATGCTCTTTGAATGGAT
ATATCCATCCTATATGCCAATTCTCCAACGGGCAATTGAGCTCTGGTACCATGATCCAGCCTGTACTACACCTGTACTCAAGTTGATGGC
TGAATTGGTTCATAATAGGTCCCAGCGACTCCAGTTTGATGTCTCTTCCCCCAATGGCATCTTACTCTTCCGAGAAACCAGCAAGATGAT
AACAATGTATGGCAATCGCATCCTGACACTAGGAGAGGTCCCAAAGGATCAGGTCTATGCTCTGAAGCTCAAGGGCATCTCCATCTGCTT
CTCCATGCTGAAGGCTGCTCTCAGTGGGAGTTACGTCAATTTCGGAGTCTTTCGTCTCTATGGAGACGATGCCCTGGACAATGCTCTGCA
GACCTTCATCAAGCTGCTCCTCTCTATTCCTCACAGTGATCTCTTGGATTACCCCAAGCTCAGCCAGTCTTATTATTCACTACTGGAAGT
CCTGACCCAGGACCATATGAACTTTATTGCAAGCCTGGAACCTCACGTCATCATGTATATTCTCTCTTCCATTTCTGAAGGACTTACTGC
ACTTGACACCATGGTATGCACAGGCTGCTGCTCCTGCCTGGACCACATTGTGACATACCTCTTCAAGCAGCTGTCACGTAGCACCAAGAA
GAGGACCACACCCCTGAACCAGGAGAGCGACCGCTTTCTGCACATCATGCAGCAGCATCCAGAGATGATCCAGCAGATGCTGTCCACGGT
GCTGAACATCATCATCTTTGAAGACTGTAGGAACCAGTGGTCTATGTCCCGACCACTACTTGGCTTGATATTGCTTAATGAAAAGTATTT
TTCTGACCTAAGAAACAGTATTGTGAACAGCCAGCCACCGGAGAAGCAGCAGGCCATGCACCTGTGTTTTGAGAACCTGATGGAAGGCAT
CGAGCGAAATCTTCTTACGAAAAACAGAGACAGGTTCACCCAGAACCTGTCAGCATTCCGTCGAGAAGTCAACGACTCAATGAAGAATTC
CACTTATGGCGTGAATAGCAATGACATGATGAGCTGACACCTCCTTGGACTCTACCTGTACAGAGCAGCGTCCCTTTGGTTTGGCCCAGA
GGGGCGAACAATTGCAAGGGAGAGGGCCTGGCTGATCCTGGCTCTTTTCTCCAGGGGTGTGGGGAAAATGGCAAAGGTCAACTAGCTGCT
TCCCCAGGGAATAGGGGTGTGAGTACACTCACTAGGGGGCAGGGCGCTGCTGGTTCCTGGGGGACTGGGTGGGAAGGGTGGTGGGAGGAG
ATAAGAGATACAAACTGAGACTCCAGCCTCTCCTCCTGGGGCCACCCAAGTGGGGAGAACCCCTAGTGTCCTGCCACAACCTGCCTTGTA
TAAACATGTACATTTTTTCATAACATTTTGAACAAGGTTTATATTGACTCAAGTTTAAAAACAAAAAGTGTGACTGAAAAATTTTTACAG
AGTCTAGTGCACCAATGCTGATGTGAGGGGTTGTGTATGCGAGTGAAGAAAATGTGTATTCTGGTGGCCTGAAGCTTTACTGGACAAGGA
TGTGTGAGAGTGCAGAGATATATTTAGTGACACAGTAGAGAGGCAAAAAAAAAGCTAAAATTCCAAATGTATATTTTTTCGTATTGCCCT
GTCCTCACCCAGAAATGATCAATTCCTGTTACTGTATTAACCCTTGTTATTAGGAACTCTAAGCCATGCCAGAACACCGTCCCTCCCCTT
GGACCGTGTAGATTCTGCCCTGGGTCCCTAGCCCCTTGCAGTGATAAATAACTCCAGCTAAAAGTGTTTGGTGTTCTTATCTCCACCCTC
TTTCCTACTTTGCTTACCCTCATCCTCAGACAGATGCCTCTTGCTTTTAAAAGTTGGATTTAACGACGTGTTGTAGGGTTCTTGGTCTGT
GTGAAGGCAGAGACCAGAGAGAAGGAAGTGAGCCCACTGCTCTCCTGGGAGCAATGTGGGTGAGTCCACCAGAGGCCCTGCTGTGTGTGG
CCAATAAATTTTAGTCTTCCCCAGCCCTCGAGGCAGTGTGTGTGGATGTATGCGTGTGGATATTTATATATGTACCCTGCACTCATGAAT
GTATGAACTGGAGGAAGTTACTACAGTGGAAGGGTTCTTAATAACAAGGTCTACCTAGCATGAAGTATTTAACATTCTCCCATCCCTTAA
AAAATATACATTTTTATAAAATGAAAACCATAATAAATGTTTTGAATATTAAAAAAAATAATAACCTACAGAGGAAAATTAATGGAGACA
GCTATTTGCCTTGTACTTTTTCCACAATTGTTGCTGCTAGTTGTACACATCTCTAGTTCAGCTCTTGCCCACGGGACACTCATCAATTAG
GTTTTATTTTTATTTCTTTCCTCTACCCCCAGAAACAAGCCTGTTAATTTTTTTTCCTTCTCCTCTGGCGACTGTGTGATGAATCCTTTC
TTGCGTGATCAGGTTGCGGATAGACTTGTAAGGGTGTTTGCTGCATACAGTGTAAGCATTGTGACCGCCAATAAACTTCAATGGTTTCTA

>91148_91148_4_TLK1-XPO7_TLK1_chr2_172016800_ENST00000431350_XPO7_chr8_21824368_ENST00000434536_length(amino acids)=1089AA_BP=1
MAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATR
PKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQVSATAFLIEADTTHPLTKHRKIA
SSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDL
YHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPEVIRL
IANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLST
IGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRL
AQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVR
KLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRT
LVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITM
YGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALDNALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLT
QDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNQESDRFLHIMQQHPEMIQQMLSTVLN
IIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTY

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Fusion Gene PPI Analysis for TLK1-XPO7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TLK1-XPO7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TLK1-XPO7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource