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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TM2D2-GOT1L1 (FusionGDB2 ID:91212)

Fusion Gene Summary for TM2D2-GOT1L1

Fusion gene summary

Fusion gene information	Fusion gene name: TM2D2-GOT1L1
	Fusion gene ID: 91212
		Hgene	Tgene
	Gene symbol	TM2D2	GOT1L1
	Gene ID	83877	137362
	Gene name	TM2 domain containing 2	glutamic-oxaloacetic transaminase 1 like 1
	Synonyms	BLP1	-
	Cytomap	8p11.22	8p11.23
	Type of gene	protein-coding	protein-coding
	Description	TM2 domain-containing protein 2BBP-like protein 1beta-amyloid-binding protein-like protein 1	putative aspartate aminotransferase, cytoplasmic 2glutamate oxaloacetate transaminase 1-like protein 1transaminase A-like protein 1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000397070, ENST00000412303, ENST00000456397, ENST00000456845, ENST00000522434,	ENST00000518826, ENST00000307599,
Fusion gene scores	* DoF score	4 X 6 X 3=72	3 X 4 X 2=24
	# samples	6	2
	** MAII score	log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/24*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TM2D2 [Title/Abstract] AND GOT1L1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TM2D2(38851064)-GOT1L1(37792004), # samples:1 TM2D2(38851064)-GOT1L1(37792733), # samples:1
Anticipated loss of major functional domain due to fusion event.	TM2D2-GOT1L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TM2D2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GOT1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-XF-AAMZ-01A	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
ChimerDB4	BLCA	TCGA-XF-AAMZ-01A	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-

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Fusion Gene ORF analysis for TM2D2-GOT1L1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000397070	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
5CDS-intron	ENST00000412303	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
5CDS-intron	ENST00000456397	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
5CDS-intron	ENST00000456845	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
5UTR-3CDS	ENST00000522434	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
5UTR-3CDS	ENST00000522434	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-
5UTR-3CDS	ENST00000522434	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-
5UTR-intron	ENST00000522434	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
Frame-shift	ENST00000397070	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-
Frame-shift	ENST00000397070	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-
Frame-shift	ENST00000412303	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
Frame-shift	ENST00000412303	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-
Frame-shift	ENST00000456397	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
Frame-shift	ENST00000456397	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-
Frame-shift	ENST00000456845	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
Frame-shift	ENST00000456845	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-
In-frame	ENST00000397070	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-
In-frame	ENST00000412303	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-
In-frame	ENST00000456397	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-
In-frame	ENST00000456845	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000397070	TM2D2	chr8	38851064	-	ENST00000307599	GOT1L1	chr8	37792004	-	1096	890	585	953	122
ENST00000456845	TM2D2	chr8	38851064	-	ENST00000518826	GOT1L1	chr8	37792733	-	784	557	252	770	172
ENST00000412303	TM2D2	chr8	38851064	-	ENST00000307599	GOT1L1	chr8	37792733	-	1046	697	392	1033	213
ENST00000456397	TM2D2	chr8	38851064	-	ENST00000307599	GOT1L1	chr8	37792733	-	874	525	94	861	255

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000397070	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792004	-	0.014860263	0.9851398
ENST00000456845	ENST00000518826	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-	0.005006867	0.99499315
ENST00000412303	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-	0.001766531	0.99823344
ENST00000456397	ENST00000307599	TM2D2	chr8	38851064	-	GOT1L1	chr8	37792733	-	0.00429968	0.99570036

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Fusion Genomic Features for TM2D2-GOT1L1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TM2D2-GOT1L1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38851064/chr8:37792004)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TM2D2

chr8:38851064

chr8:37792004

ENST00000397070

145_165

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792004

ENST00000397070

183_203

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792004

ENST00000412303

145_165

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792004

ENST00000412303

183_203

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792004

ENST00000456397

145_165

143

215.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792004

ENST00000456397

183_203

143

215.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792004

ENST00000456845

145_165

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792004

ENST00000456845

183_203

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792733

ENST00000397070

145_165

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792733

ENST00000397070

183_203

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792733

ENST00000412303

145_165

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792733

ENST00000412303

183_203

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792733

ENST00000456397

145_165

143

215.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792733

ENST00000456397

183_203

143

215.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792733

ENST00000456845

145_165

100

172.0

Transmembrane

Helical

Hgene

TM2D2

chr8:38851064

chr8:37792733

ENST00000456845

183_203

100

172.0

Transmembrane

Helical

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Fusion Gene Sequence for TM2D2-GOT1L1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91212_91212_1_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000397070_GOT1L1_chr8_37792004_ENST00000307599_length(transcript)=1096nt_BP=890nt
AGTTCTTGGGTCTGTGCTGCTGGCCTGGGGTTGTGGTTGAGGCCGGGTCTCCGCTCCTGTGCCCGGGAAGATGGTGCTAGGTGGTTGCCC
GGTTAGTTACTTACTTCTGTGCGGCCAGGCGGCTTTGCTGCTGGGGAATTTACTTCTGCTGCATTGTGTGTCTCGGAGCCACTCGCAAAA
TGCGACCGCTGAGCCTGAGCTCACATCCGCTGGCGCCGCCCAGCCGGAGGGCCCCGGGGGTGCTGCGAGCTGGGAATATGGCGACCCCCA
CTCTCCGGTCATCCTCTGCTCTTACCTAATCACGCCATTTTTTAACATCTCTTTTTGATCAAACAAGAAAAGGCATTTGGGAAATGCAAA
GAGGACTGAGAATACTTTGGCTTAAATTTTGCCCCCAGAATCTTGTTGTTTGCCTACTGAAGAGATGAAACCATGGCAGAAGTAGAATCC
TTATAGAAACAGGACCAGAAACACCTCCCTTCTCCAACAAAAGGTTCATTTTGGTGGCTGTCCGTTTGACCTGCTGTGCTTCAGTTTAAT
TGGCTTGGAAAGGGGTCAGCAGGGTGAAACCGAACCCCAGAAAACTTGATGAAGAAATGTCTTTTGCCCGTTTTGATTACGTGCATGCAA
ACAGCGATTTGCAAAGACCGTATGATGATGATCATGATCTTACTGGTGAATTACAGACCTGATGAATTTATAGAATGTGAAGACCCAGTG
GATCATGTTGGAAATGCAACTGCATCCCAGGAACTTGGTTATGGTTGTCTCAAGTTCGGCGGTCAGGCCTACAGCGACGTGGAACACACT
TCAGTCCAGTGCCATGCCTTAGATGGAATTGAGTGTGCCAGTCCTAGGACCTTTCTACGAGAAAATAAACCTTGTATAAACCCAGCAGGT
GGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACAT
CACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATAAAACT

>91212_91212_1_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000397070_GOT1L1_chr8_37792004_ENST00000307599_length(amino acids)=122AA_BP=102
MMKKCLLPVLITCMQTAICKDRMMMIMILLVNYRPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASP

--------------------------------------------------------------
>91212_91212_2_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000412303_GOT1L1_chr8_37792733_ENST00000307599_length(transcript)=1046nt_BP=697nt
GGCCTGACCACGCAGTTCTTGGGTCTGTGCTGCTGGCCTGGGGTTGTGGTTGAGGCCGGGTCTCCGCTCCTGTGCCCGGGAAGATGGTGC
TAGGTGGTTGCCCGAATCACGCCATTTTTTAACATCTCTTTTTGATCAAACAAGAAAAGGCATTTGGGAAATGCAAAGAGGACTGAGAAT
ACTTTGGCTTAAATTTTGCCCCCAGAATCTTGTTGTTTGCCTACTGAAGAGATGAAACCATGGCAGAAGTAGAATCCTTATAGAAACAGG
ACCAGAAACACCTCCCTTCTCCAACAAAAGGTTCATTTTGGTGGCTGTCCGTTTGACCTGCTGTGCTTCAGTTTAATTGGCTTGGAAAGG
GGTCAGCAGGGTGAAACCGAACCCCAGAAAACTTGATGAAGAAATGTCTTTTGCCCGTTTTGATTACGTGCATGCAAACAGCGATTTGCA
AAGACCGTATGATGATGATCATGATCTTACTGGTGAATTACAGACCTGATGAATTTATAGAATGTGAAGACCCAGTGGATCATGTTGGAA
ATGCAACTGCATCCCAGGAACTTGGTTATGGTTGTCTCAAGTTCGGCGGTCAGGCCTACAGCGACGTGGAACACACTTCAGTCCAGTGCC
ATGCCTTAGATGGAATTGAGTGTGCCAGTCCTAGGACCTTTCTACGAGAAAATAAACCTTGTATAAAGAAGCAGAGTCTAAAAGAAGTTG
TAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGA
GTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGA
TTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGT

>91212_91212_2_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000412303_GOT1L1_chr8_37792733_ENST00000307599_length(amino acids)=213AA_BP=102
MMKKCLLPVLITCMQTAICKDRMMMIMILLVNYRPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASP
RTFLRENKPCIKKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQQVEYLVRKKHIYIPKNGQINFSCINANNI

--------------------------------------------------------------
>91212_91212_3_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000456397_GOT1L1_chr8_37792733_ENST00000307599_length(transcript)=874nt_BP=525nt
CTACGCGGAAAGGCCTGACCACGCAGTTCTTGGGTCTGTGCTGCTGGCCTGGGGTTGTGGTTGAGGCCGGGTCTCCGCTCCTGTGCCCGG
GAAGATGGTGCTAGGTGGTTGCCCGGTTAGTTACTTACTTCTGTGCGGCCAGGCGGCTTTGCTGCTGGGGAATTTACTTCTGCTGCATTG
TGTGTCTCGGAGCCACTCGCAAAATGCGACCGCTGAGCCTGAGCTCACATCCGCTGGCGCCGCCCAGCCGGAGGGCCCCGGGGGTGCTGC
GAGCTGGGAATATGGCGACCCCCACTCTCCGGTCATCCTCTGCTCTTACCTACCTGATGAATTTATAGAATGTGAAGACCCAGTGGATCA
TGTTGGAAATGCAACTGCATCCCAGGAACTTGGTTATGGTTGTCTCAAGTTCGGCGGTCAGGCCTACAGCGACGTGGAACACACTTCAGT
CCAGTGCCATGCCTTAGATGGAATTGAGTGTGCCAGTCCTAGGACCTTTCTACGAGAAAATAAACCTTGTATAAAGAAGCAGAGTCTAAA
AGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCAC
CGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAA
CGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTC

>91212_91212_3_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000456397_GOT1L1_chr8_37792733_ENST00000307599_length(amino acids)=255AA_BP=144
MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSQNATAEPELTSAGAAQPEGPGGAASWEYGDPHSPVILCSYLPDEFIECEDPVDHV
GNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASPRTFLRENKPCIKKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITE

--------------------------------------------------------------
>91212_91212_4_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000456845_GOT1L1_chr8_37792733_ENST00000518826_length(transcript)=784nt_BP=557nt
GGGGTTGTGGTTGAGGCCGGGTCTCCGCTCCTGTGCCCGGGAAGATGGTGCTAGGTGGTTGCCCGAATCTTGTTGTTTGCCTACTGAAGA
GATGAAACCATGGCAGAAGTAGAATCCTTATAGAAACAGGACCAGAAACACCTCCCTTCTCCAACAAAAGGTTCATTTTGGTGGCTGTCC
GTTTGACCTGCTGTGCTTCAGTTTAATTGGCTTGGAAAGGGGTCAGCAGGGTGAAACCGAACCCCAGAAAACTTGATGAAGAAATGTCTT
TTGCCCGTTTTGATTACGTGCATGCAAACAGCGATTTGCAAAGACCGTATGATGATGATCATGATCTTACTGGTGAATTACAGACCTGAT
GAATTTATAGAATGTGAAGACCCAGTGGATCATGTTGGAAATGCAACTGCATCCCAGGAACTTGGTTATGGTTGTCTCAAGTTCGGCGGT
CAGGCCTACAGCGACGTGGAACACACTTCAGTCCAGTGCCATGCCTTAGATGGAATTGAGTGTGCCAGTCCTAGGACCTTTCTACGAGAA
AATAAACCTTGTATAAAGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGCTC
CTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTGTAAGGGTCTAGGGGGCTGG

>91212_91212_4_TM2D2-GOT1L1_TM2D2_chr8_38851064_ENST00000456845_GOT1L1_chr8_37792733_ENST00000518826_length(amino acids)=172AA_BP=102
MMKKCLLPVLITCMQTAICKDRMMMIMILLVNYRPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQCHALDGIECASP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TM2D2-GOT1L1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TM2D2-GOT1L1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TM2D2-GOT1L1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source