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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TM9SF1-ATP5B (FusionGDB2 ID:91240)

Fusion Gene Summary for TM9SF1-ATP5B

Fusion gene summary

Fusion gene information	Fusion gene name: TM9SF1-ATP5B
	Fusion gene ID: 91240
		Hgene	Tgene
	Gene symbol	TM9SF1	ATP5B
	Gene ID	10548	506
	Gene name	transmembrane 9 superfamily member 1	ATP synthase F1 subunit beta
	Synonyms	HMP70\|MP70	ATP5B\|ATPMB\|ATPSB\|HEL-S-271
	Cytomap	14q12	12q13.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane 9 superfamily member 1MP70 protein family membermultispanning membrane protein (70kD)transmembrane protein 9 superfamily member 1	ATP synthase subunit beta, mitochondrialATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptideepididymis secretory protein Li 271mitochondrial ATP synthase beta subunitmitochondrial ATP synthetase, beta subunit
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000261789, ENST00000396854, ENST00000524835, ENST00000528669, ENST00000530611, ENST00000556387,	ENST00000550162, ENST00000552919, ENST00000262030,
Fusion gene scores	* DoF score	4 X 4 X 4=64	9 X 10 X 4=360
	# samples	4	11
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TM9SF1 [Title/Abstract] AND ATP5B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TM9SF1(24663881)-ATP5B(57032207), # samples:2
Anticipated loss of major functional domain due to fusion event.	TM9SF1-ATP5B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. TM9SF1-ATP5B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ATP5B	GO:0042776	mitochondrial ATP synthesis coupled proton transport	12110673

Fusion gene breakpoints across TM9SF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR188031	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-

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Fusion Gene ORF analysis for TM9SF1-ATP5B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000261789	ENST00000550162	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
5CDS-intron	ENST00000396854	ENST00000550162	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
5CDS-intron	ENST00000524835	ENST00000550162	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
5CDS-intron	ENST00000528669	ENST00000550162	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
5CDS-intron	ENST00000530611	ENST00000550162	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
5CDS-intron	ENST00000556387	ENST00000550162	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
Frame-shift	ENST00000261789	ENST00000552919	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
Frame-shift	ENST00000396854	ENST00000552919	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
Frame-shift	ENST00000524835	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
Frame-shift	ENST00000524835	ENST00000552919	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
Frame-shift	ENST00000528669	ENST00000552919	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
Frame-shift	ENST00000530611	ENST00000552919	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
Frame-shift	ENST00000556387	ENST00000552919	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
In-frame	ENST00000261789	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
In-frame	ENST00000396854	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
In-frame	ENST00000528669	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
In-frame	ENST00000530611	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-
In-frame	ENST00000556387	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261789	TM9SF1	chr14	24663881	-	ENST00000262030	ATP5B	chr12	57032207	-	953	704	359	922	187
ENST00000528669	TM9SF1	chr14	24663881	-	ENST00000262030	ATP5B	chr12	57032207	-	983	734	338	952	204
ENST00000556387	TM9SF1	chr14	24663881	-	ENST00000262030	ATP5B	chr12	57032207	-	1255	1006	1	1224	407
ENST00000530611	TM9SF1	chr14	24663881	-	ENST00000262030	ATP5B	chr12	57032207	-	1255	1006	1	1224	407
ENST00000396854	TM9SF1	chr14	24663881	-	ENST00000262030	ATP5B	chr12	57032207	-	884	635	290	853	187

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261789	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-	0.18142432	0.8185757
ENST00000528669	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-	0.1710565	0.8289435
ENST00000556387	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-	0.005713669	0.99428636
ENST00000530611	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-	0.005713669	0.99428636
ENST00000396854	ENST00000262030	TM9SF1	chr14	24663881	-	ATP5B	chr12	57032207	-	0.16327468	0.8367253

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Fusion Genomic Features for TM9SF1-ATP5B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TM9SF1-ATP5B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:24663881/chr12:57032207)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000261789

237_257

115

607.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000261789

310_330

115

607.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000261789

339_359

115

607.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000261789

373_393

115

607.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000261789

412_432

115

607.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000261789

469_489

115

607.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000261789

499_519

115

607.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000261789

535_555

115

607.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000261789

570_590

115

607.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000396854

237_257

115

490.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000396854

310_330

115

490.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000396854

339_359

115

490.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000396854

373_393

115

490.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000396854

412_432

115

490.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000396854

469_489

115

490.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000396854

499_519

115

490.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000396854

535_555

115

490.0

Transmembrane

Helical

Hgene

TM9SF1

chr14:24663881

chr12:57032207

ENST00000396854

570_590

115

490.0

Transmembrane

Helical

Tgene

ATP5B

chr14:24663881

chr12:57032207

ENST00000262030

207_214

496

530.0

Nucleotide binding

ATP

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Fusion Gene Sequence for TM9SF1-ATP5B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91240_91240_1_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000261789_ATP5B_chr12_57032207_ENST00000262030_length(transcript)=953nt_BP=704nt
GACGTGTCCTGGGCCGCGCTGCCGATCGCCGGGAGGACCCCCGCCTCGCCGAAGACGGGCGGGGCAAGCCGAGCCTCACGGGGTCCCCGG
AGCTGGGCCGGGCCTCCAGATGGAGAAGGCGCAACGGGGAGTTCTTGAGTAAGCCAGAGCGGTGTCCAGCGCGGTGTAGCCGCAGCCGCC
GCTGTCAGGCGCAGCAACGGGCAACCCCGTAGAAGTCGGTCGGCAGGTCCTCTCCAACCCGCCGCTACCGCGCCGCTGTGGGAGAGACCC
CAGCAGGAGCCCAAAGGCAGCTACGGGGGCGCGAAGGCCGCTGGCGCCGCCTCGGCCAGCCCTTCCCGCGCGGTTCCACTGCCTTAAGGA
TGACAGTCGTAGGGAACCCTCGAAGTTGGAGCTGCCAGTGGTTGCCAATCCTGATACTGTTGCTGGGCACAGGCCATGGGCCAGGGGTGG
AAGGCGTGACACACTACAAGGCCGGCGACCCTGTTATTCTGTATGTCAACAAAGTGGGACCCTACCATAACCCTCAGGAAACTTACCACT
ACTATCAGCTTCCAGTCTGCTGCCCTGAGAAGATACGTCACAAAAGCCTTAGCCTGGGTGAAGTGCTGGATGGGGACCGAATGGCTGAGT
CTTTGTATGAGATCCGCTTTCGGGAAAACGTGGAGAAGAGAATTCTGTGCCACATGCAGCTCAGTTCTGCACAGGTGAATATGACCATCT
CCCAGAACAGGCCTTCTATATGGTGGGACCCATTGAAGAAGCTGTGGCAAAAGCTGATAAGCTGGCTGAAGAGCATTCATCGTGAGGGGT
CTTTGTCCTCTGTACTGTCTCTCTCCTTGCCCCTAACCCAAAAAGCTTCATTTTTCTGTGTAGGCTGCACAAGAGCCTTGATTGAAGATA

>91240_91240_1_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000261789_ATP5B_chr12_57032207_ENST00000262030_length(amino acids)=187AA_BP=114
MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAE
SLYEIRFRENVEKRILCHMQLSSAQVNMTISQNRPSIWWDPLKKLWQKLISWLKSIHREGSLSSVLSLSLPLTQKASFFCVGCTRALIED

--------------------------------------------------------------
>91240_91240_2_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000396854_ATP5B_chr12_57032207_ENST00000262030_length(transcript)=884nt_BP=635nt
CGAGCCTCACGGGGTCCCCGGAGCTGGGCCGGGCCTCCAGATGGAGAAGGCGCAACGGGGAGTTCTTGAGTAAGCCAGAGCGGTGTCCAG
CGCGGTGTAGCCGCAGCCGCCGCTGTCAGGCGCAGCAACGGGCAACCCCGTAGAAGTCGGTCGGCAGGTCCTCTCCAACCCGCCGCTACC
GCGCCGCTGTGGGAGAGACCCCAGCAGGAGCCCAAAGGCAGCTACGGGGGCGCGAAGGCCGCTGGCGCCGCCTCGGCCAGCCCTTCCCGC
GCGGTTCCACTGCCTTAAGGATGACAGTCGTAGGGAACCCTCGAAGTTGGAGCTGCCAGTGGTTGCCAATCCTGATACTGTTGCTGGGCA
CAGGCCATGGGCCAGGGGTGGAAGGCGTGACACACTACAAGGCCGGCGACCCTGTTATTCTGTATGTCAACAAAGTGGGACCCTACCATA
ACCCTCAGGAAACTTACCACTACTATCAGCTTCCAGTCTGCTGCCCTGAGAAGATACGTCACAAAAGCCTTAGCCTGGGTGAAGTGCTGG
ATGGGGACCGAATGGCTGAGTCTTTGTATGAGATCCGCTTTCGGGAAAACGTGGAGAAGAGAATTCTGTGCCACATGCAGCTCAGTTCTG
CACAGGTGAATATGACCATCTCCCAGAACAGGCCTTCTATATGGTGGGACCCATTGAAGAAGCTGTGGCAAAAGCTGATAAGCTGGCTGA
AGAGCATTCATCGTGAGGGGTCTTTGTCCTCTGTACTGTCTCTCTCCTTGCCCCTAACCCAAAAAGCTTCATTTTTCTGTGTAGGCTGCA

>91240_91240_2_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000396854_ATP5B_chr12_57032207_ENST00000262030_length(amino acids)=187AA_BP=114
MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAE
SLYEIRFRENVEKRILCHMQLSSAQVNMTISQNRPSIWWDPLKKLWQKLISWLKSIHREGSLSSVLSLSLPLTQKASFFCVGCTRALIED

--------------------------------------------------------------
>91240_91240_3_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000528669_ATP5B_chr12_57032207_ENST00000262030_length(transcript)=983nt_BP=734nt
CCCAAAGGCAGCTACGGGGGCGCGAAGGCCGCTGGCGCCGCCTCGGCCAGCCCTTCCCGCGCGGTGAGGACCCCGGGGCTGTGGCGGGAA
GGGACCCGAGGTGCGAGACCGAGCGGCGTTGCCATGGAAACGGGCCAGGGCGCGTAGTAGAGGCCCCGGGCCAGACGGGCTGCGGGTGGG
GTGAACCCCAGGTTGGGAGGATGAGAGAGCAGAGGTGGAGCGGGGTCTTTGGGATAGAGAGACGTGGGGTAGGGTGAGGCGGGGAGGGGG
CCAATGGGAGCAAGTGGAGCCAGGGGACCTCAGTTCGAGGCACCTGACCTGGGGTTTCTGTAACCTCCCTGGTTTCTATAACCTCAGGAT
TCCCCCAAACAGGTTCCACTGCCTTAAGGATGACAGTCGTAGGGAACCCTCGAAGTTGGAGCTGCCAGTGGTTGCCAATCCTGATACTGT
TGCTGGGCACAGGCCATGGGCCAGGGGTGGAAGGCGTGACACACTACAAGGCCGGCGACCCTGTTATTCTGTATGTCAACAAAGTGGGAC
CCTACCATAACCCTCAGGAAACTTACCACTACTATCAGCTTCCAGTCTGCTGCCCTGAGAAGATACGTCACAAAAGCCTTAGCCTGGGTG
AAGTGCTGGATGGGGACCGAATGGCTGAGTCTTTGTATGAGATCCGCTTTCGGGAAAACGTGGAGAAGAGAATTCTGTGCCACATGCAGC
TCAGTTCTGCACAGGTGAATATGACCATCTCCCAGAACAGGCCTTCTATATGGTGGGACCCATTGAAGAAGCTGTGGCAAAAGCTGATAA
GCTGGCTGAAGAGCATTCATCGTGAGGGGTCTTTGTCCTCTGTACTGTCTCTCTCCTTGCCCCTAACCCAAAAAGCTTCATTTTTCTGTG

>91240_91240_3_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000528669_ATP5B_chr12_57032207_ENST00000262030_length(amino acids)=204AA_BP=131
MVSITSGFPQTGSTALRMTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIR
HKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVNMTISQNRPSIWWDPLKKLWQKLISWLKSIHREGSLSSVLSLSLPLT

--------------------------------------------------------------
>91240_91240_4_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000530611_ATP5B_chr12_57032207_ENST00000262030_length(transcript)=1255nt_BP=1006nt
GCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCTCTTCGGGAAGGGGAAGAAGGAGAAAGGGCCAACCCC
TGAAGAAGCAATACAGAAACTGAAGGAGACAGAGAAGATACTGATCAAGAAACAGGAATTTTTGGAGCAGAAGATTCAACAGGAGCTACA
AACAGCCAAGAAGTATGGGACCAAGAATAAGAGAGCTGCCCTACAGGCTTTGCGGAGGAAGAAAAGATTCGAACAGCAGCTGGCACAAAC
TGACGGGACATTATCCACCCTGGAGTTTCAGCGTGAGGCCATTGAGAATGCCACTACCAATGCAGAAGTCCTTCGTACCATGGAGCTTGC
TGCCCAAAGCATGAAGAAGGCCTACCAGGACATGGACATTGACAAGGTAGATGAACTGATGACTGACATCACGGAACAACAGGAGGTGGC
CCAGCAGATCTCAGATGCCATTTCTCGGCCTATGGGCTTTGGAGATGATGTGGATGAGGATGAACTGCTGGAGGAGCTAGAGGAGCTGGA
GCAGGAGGAATTGGCCCAGGAGTTGTTAAATGTGGGCGACAAGGAAGAAGAACCCTCAGTCAAATTGCCTAGTGTACCTTCTACTCATCT
GCCGGCAGGGCCAGGTTCCACTGCCTTAAGGATGACAGTCGTAGGGAACCCTCGAAGTTGGAGCTGCCAGTGGTTGCCAATCCTGATACT
GTTGCTGGGCACAGGCCATGGGCCAGGGGTGGAAGGCGTGACACACTACAAGGCCGGCGACCCTGTTATTCTGTATGTCAACAAAGTGGG
ACCCTACCATAACCCTCAGGAAACTTACCACTACTATCAGCTTCCAGTCTGCTGCCCTGAGAAGATACGTCACAAAAGCCTTAGCCTGGG
TGAAGTGCTGGATGGGGACCGAATGGCTGAGTCTTTGTATGAGATCCGCTTTCGGGAAAACGTGGAGAAGAGAATTCTGTGCCACATGCA
GCTCAGTTCTGCACAGGTGAATATGACCATCTCCCAGAACAGGCCTTCTATATGGTGGGACCCATTGAAGAAGCTGTGGCAAAAGCTGAT
AAGCTGGCTGAAGAGCATTCATCGTGAGGGGTCTTTGTCCTCTGTACTGTCTCTCTCCTTGCCCCTAACCCAAAAAGCTTCATTTTTCTG

>91240_91240_4_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000530611_ATP5B_chr12_57032207_ENST00000262030_length(amino acids)=407AA_BP=334
LRGGGGRGELAMSGLGRLFGKGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTKNKRAALQALRRKKRFEQQLAQT
DGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISRPMGFGDDVDEDELLEELEELE
QEELAQELLNVGDKEEEPSVKLPSVPSTHLPAGPGSTALRMTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVG
PYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVNMTISQNRPSIWWDPLKKLWQKLI

--------------------------------------------------------------
>91240_91240_5_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000556387_ATP5B_chr12_57032207_ENST00000262030_length(transcript)=1255nt_BP=1006nt
GCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCTCTTCGGGAAGGGGAAGAAGGAGAAAGGGCCAACCCC
TGAAGAAGCAATACAGAAACTGAAGGAGACAGAGAAGATACTGATCAAGAAACAGGAATTTTTGGAGCAGAAGATTCAACAGGAGCTACA
AACAGCCAAGAAGTATGGGACCAAGAATAAGAGAGCTGCCCTACAGGCTTTGCGGAGGAAGAAAAGATTCGAACAGCAGCTGGCACAAAC
TGACGGGACATTATCCACCCTGGAGTTTCAGCGTGAGGCCATTGAGAATGCCACTACCAATGCAGAAGTCCTTCGTACCATGGAGCTTGC
TGCCCAAAGCATGAAGAAGGCCTACCAGGACATGGACATTGACAAGGTAGATGAACTGATGACTGACATCACGGAACAACAGGAGGTGGC
CCAGCAGATCTCAGATGCCATTTCTCGGCCTATGGGCTTTGGAGATGATGTGGATGAGGATGAACTGCTGGAGGAGCTAGAGGAGCTGGA
GCAGGAGGAATTGGCCCAGGAGTTGTTAAATGTGGGCGACAAGGAAGAAGAACCCTCAGTCAAATTGCCTAGTGTACCTTCTACTCATCT
GCCGGCAGGGCCAGGTTCCACTGCCTTAAGGATGACAGTCGTAGGGAACCCTCGAAGTTGGAGCTGCCAGTGGTTGCCAATCCTGATACT
GTTGCTGGGCACAGGCCATGGGCCAGGGGTGGAAGGCGTGACACACTACAAGGCCGGCGACCCTGTTATTCTGTATGTCAACAAAGTGGG
ACCCTACCATAACCCTCAGGAAACTTACCACTACTATCAGCTTCCAGTCTGCTGCCCTGAGAAGATACGTCACAAAAGCCTTAGCCTGGG
TGAAGTGCTGGATGGGGACCGAATGGCTGAGTCTTTGTATGAGATCCGCTTTCGGGAAAACGTGGAGAAGAGAATTCTGTGCCACATGCA
GCTCAGTTCTGCACAGGTGAATATGACCATCTCCCAGAACAGGCCTTCTATATGGTGGGACCCATTGAAGAAGCTGTGGCAAAAGCTGAT
AAGCTGGCTGAAGAGCATTCATCGTGAGGGGTCTTTGTCCTCTGTACTGTCTCTCTCCTTGCCCCTAACCCAAAAAGCTTCATTTTTCTG

>91240_91240_5_TM9SF1-ATP5B_TM9SF1_chr14_24663881_ENST00000556387_ATP5B_chr12_57032207_ENST00000262030_length(amino acids)=407AA_BP=334
LRGGGGRGELAMSGLGRLFGKGKKEKGPTPEEAIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTKNKRAALQALRRKKRFEQQLAQT
DGTLSTLEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISRPMGFGDDVDEDELLEELEELE
QEELAQELLNVGDKEEEPSVKLPSVPSTHLPAGPGSTALRMTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVG
PYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVNMTISQNRPSIWWDPLKKLWQKLI

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Fusion Gene PPI Analysis for TM9SF1-ATP5B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TM9SF1-ATP5B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TM9SF1-ATP5B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source