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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TM9SF4-COMMD7 (FusionGDB2 ID:91269)

Fusion Gene Summary for TM9SF4-COMMD7

Fusion gene summary

Fusion gene information	Fusion gene name: TM9SF4-COMMD7
	Fusion gene ID: 91269
		Hgene	Tgene
	Gene symbol	TM9SF4	COMMD7
	Gene ID	9777	149951
	Gene name	transmembrane 9 superfamily member 4	COMM domain containing 7
	Synonyms	dJ836N17.2	C20orf92\|dJ1085F17.3
	Cytomap	20q11.21	20q11.21
	Type of gene	protein-coding	protein-coding
	Description	transmembrane 9 superfamily member 4dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4transmembrane 9 superfamily protein member 4tumor cannibalism associated protein 1	COMM domain-containing protein 7
	Modification date	20200313	20200313
	UniProtAcc	.	Q86VX2
	Ensembl transtripts involved in fusion gene	ENST00000217315, ENST00000398022,	ENST00000278980, ENST00000446419,
Fusion gene scores	* DoF score	20 X 19 X 14=5320	7 X 5 X 6=210
	# samples	28	9
	** MAII score	log2(28/5320*10)=-4.24792751344359 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TM9SF4 [Title/Abstract] AND COMMD7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TM9SF4(30749168)-COMMD7(31315949), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TM9SF4	GO:0001666	response to hypoxia	25961573
Tgene	COMMD7	GO:0032088	negative regulation of NF-kappaB transcription factor activity	15799966
Tgene	COMMD7	GO:0033209	tumor necrosis factor-mediated signaling pathway	15799966
Tgene	COMMD7	GO:0045892	negative regulation of transcription, DNA-templated	15799966

Fusion gene breakpoints across TM9SF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across COMMD7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	COAD	TCGA-A6-2675-01A	TM9SF4	chr20	30749168	-	COMMD7	chr20	31315949	-
ChimerDB4	COAD	TCGA-A6-2675-01A	TM9SF4	chr20	30749168	+	COMMD7	chr20	31315949	-

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Fusion Gene ORF analysis for TM9SF4-COMMD7

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000217315	ENST00000278980	TM9SF4	chr20	30749168	+	COMMD7	chr20	31315949	-
In-frame	ENST00000217315	ENST00000446419	TM9SF4	chr20	30749168	+	COMMD7	chr20	31315949	-
In-frame	ENST00000398022	ENST00000278980	TM9SF4	chr20	30749168	+	COMMD7	chr20	31315949	-
In-frame	ENST00000398022	ENST00000446419	TM9SF4	chr20	30749168	+	COMMD7	chr20	31315949	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000398022	TM9SF4	chr20	30749168	+	ENST00000278980	COMMD7	chr20	31315949	-	3224	2014	235	2532	765
ENST00000398022	TM9SF4	chr20	30749168	+	ENST00000446419	COMMD7	chr20	31315949	-	3209	2014	235	2529	764
ENST00000217315	TM9SF4	chr20	30749168	+	ENST00000278980	COMMD7	chr20	31315949	-	3278	2068	148	2586	812
ENST00000217315	TM9SF4	chr20	30749168	+	ENST00000446419	COMMD7	chr20	31315949	-	3263	2068	148	2583	811

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398022	ENST00000278980	TM9SF4	chr20	30749168	+	COMMD7	chr20	31315949	-	0.000726163	0.99927384
ENST00000398022	ENST00000446419	TM9SF4	chr20	30749168	+	COMMD7	chr20	31315949	-	0.000747088	0.99925286
ENST00000217315	ENST00000278980	TM9SF4	chr20	30749168	+	COMMD7	chr20	31315949	-	0.001836682	0.9981633
ENST00000217315	ENST00000446419	TM9SF4	chr20	30749168	+	COMMD7	chr20	31315949	-	0.00172699	0.998273

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Fusion Genomic Features for TM9SF4-COMMD7

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TM9SF4-COMMD7

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:30749168/chr20:31315949)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	COMMD7 Q86VX2
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966). {ECO:0000269\|PubMed:15799966, ECO:0000305\|PubMed:21778237}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

24_281

576

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

303_346

576

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

368_376

576

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

398_416

576

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

438_449

576

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

471_501

576

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

523_535

576

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

557_570

576

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

24_281

593

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

303_346

593

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

368_376

593

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

398_416

593

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

438_449

593

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

471_501

593

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

523_535

593

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

557_570

593

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

282_302

576

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

347_367

576

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

377_397

576

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

417_437

576

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

450_470

576

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

502_522

576

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

536_556

576

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

282_302

593

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

347_367

593

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

377_397

593

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

417_437

593

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

450_470

593

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

502_522

593

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

536_556

593

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

571_591

593

643.0

Transmembrane

Helical

Tgene

COMMD7

chr20:30749168

chr20:31315949

ENST00000278980

133_200

201.0

Domain

COMM

Tgene

COMMD7

chr20:30749168

chr20:31315949

ENST00000446419

133_200

200.0

Domain

COMM

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

592_598

576

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

620_642

576

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

592_598

593

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

620_642

593

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

571_591

576

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000217315

599_619

576

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30749168

chr20:31315949

ENST00000398022

599_619

593

643.0

Transmembrane

Helical

Top

Fusion Gene Sequence for TM9SF4-COMMD7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91269_91269_1_TM9SF4-COMMD7_TM9SF4_chr20_30749168_ENST00000217315_COMMD7_chr20_31315949_ENST00000278980_length(transcript)=3278nt_BP=2068nt
CCAAGATGGCGACGGCGATGGTGAGTGAAGGAGACTCCGGGAGCGGGAGCTGGAGCGGGGCCCTCCGGGGTATCCCAGGATCTTCCAGCA
CCCCATGCCTGGCCCTGAGCCACCTCCGGGACCCCTGACTCAGGCCTGAGGGCTACCTCTGACTGGGCTTGTCTTCCCCGAAATCCACCT
CCCTGGCCCTGCCCCTGCACTCAGGCTTGTGAAGGCCCCGAGTTTTGGGGGAGGCGCCGTTTCGGAGGAAGACCTCGGCTGCTGCCTTCG
CCGGTTCCCATTCTACTTTTGGTCTCCGCCCACTGATTGGTTGCCGTGGTCTTTACTGCTTTTCTCCCTGATGTGTGAAACAAGCGCCTT
CTATGTGCCTGGGGTCGCGCCTATCAACTTCCACCAGAACGATCCCGTAGAAATCAAGGCTGTGAAGCTCACCAGCTCTCGAACCCAGCT
ACCTTATGAATACTATTCACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAAGGCAGAGAATCTGGGAGAGGTGCTGAGAGGGGACCG
GATTGTCAACACCCCTTTCCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGTTCTGTGCAGCCAGTCCAACAAGCCAGTGACCCTGAC
AGTGGAGCAGAGCCGACTCGTGGCCGAGCGGATCACAGAAGACTACTACGTCCACCTCATTGCTGACAACCTGCCTGTGGCCACCCGGCT
GGAGCTCTACTCCAACCGAGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCAGTTTGAACACGGCTACCGGCTCGGCTTCACAGATGT
CAACAAGATCTACCTGCACAACCACCTCTCATTCATCCTTTACTATCATCGGGAGGACATGGAAGAGGACCAGGAGCACACGTACCGTGT
CGTCCGCTTCGAGGTGATTCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGATGAGAAGAGTTCGTGCACTCTGCCTGAGGGTACCAA
CTCCTCGCCCCAAGAAATTGACCCCACCAAGGAGAATCAGCTGTACTTCACCTACTCTGTCCACTGGGAGGAAAGTGATATCAAATGGGC
CTCTCGCTGGGACACTTACCTGACCATGAGTGACGTCCAGATCCACTGGTTTTCTATCATTAACTCCGTTGTTGTGGTCTTCTTCCTGTC
AGGTATCCTGAGCATGATTATCATTCGGACCCTCCGGAAGGACATTGCCAACTACAACAAGGAGGATGACATTGAAGACACCATGGAGGA
GTCTGGGTGGAAGTTGGTGCACGGCGACGTCTTCAGGCCCCCCCAGTACCCCATGATCCTCAGCTCCCTGCTGGGCTCAGGCATTCAGCT
GTTCTGTATGATCCTCATCGTCATCTTTGTAGCCATGCTTGGGATGCTGTCGCCCTCCAGCCGGGGAGCTCTCATGACCACAGCCTGCTT
CCTCTTCATGTTCATGGGGGTGTTTGGCGGATTTTCTGCTGGCCGTCTGTACCGCACTTTAAAAGGCCATCGGTGGAAGAAAGGAGCCTT
CTGTACGGCAACTCTGTACCCTGGTGTGGTTTTTGGCATCTGCTTCGTATTGAATTGCTTCATTTGGGGAAAGCACTCATCAGGAGCGGT
GCCCTTTCCCACCATGGTGGCTCTGCTGTGCATGTGGTTCGGGATCTCCCTGCCCCTCGTCTACTTGGGCTACTACTTCGGCTTCCGAAA
GCAGCCATATGACAACCCTGTGCGCACCAACCAGATTCCCCGGCAGATCCCCGAGCAGCGGTGGTACATGAACCGATTTGTGGGCATCCT
CATGGCTGGGATCTTGCCCTTCGGCGCCATGTTCATCGAGCTCTTCTTCATCTTCAGTGCTATCTGGGAGAATCAGTTCTATTACCTCTT
TGGCTTCCTGTTCCTTGTTTTCATCATCCTGGTGGTATCCTGTTCACAAATCAGCATCGTCATGGTGTACTTCCAGCTGTGTGCAGAGGA
TTACCGCTGGTGGTGGAGAAATTTCCTAGTCTCCGGGGGCTCTGCATTCTACGTCCTGGTTTATGCCATCTTTTATTTCGTTAACAAGCA
GTTCTCAGCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCAC
CACCAATCAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGTGCTTTGAAGAAGAGTCTCACAGC
CAAGCAGGTCCAGGCGGATTTCATAACTCTGGGTCTTAGTGAGGAGAAAGCCACTTACTTTTCTGAAAAGTGGAAGCAGAATGCTCCCAC
CCTTGCTCGATGGGCCATAGGTCAGACTCTGATGATTAACCAGCTCATAGATATGGAGTGGAAATTTGGAGTGACATCTGGGAGCAGCGA
ATTGGAGAAAGTGGGAAGTATATTTTTACAACTAAAGTTGGTGGTTAAGAAAGGAAATCAAACCGAAAATGTGTATATAGAATTAACCTT
GCCTCAGTTCTACAGCTTCCTGCACGAGATGGAGCGAGTCAGAACCAGCATGGAGTGTTTCTGCTGATTTCTGTCCCTGCATCTCCCCTG
GCCCCGTTCCCTGCCCTCCTCCCTTCCCTGGGTGACTGCTCTGAGAGGCACTTCACTCACAGGCCTGTGGGATGCTCCATGGGGCCCTGC
TGGCTCCATGGGGCCCAGGTGCAAAGGGTTTCTGAAAAACAGCAGGATTAAGTACTGAAAGAGCCCAACACAATTACCCTGTAAACTCTC
TGTTAGGGCAACCACCACCACCTGTCTTCCAGGACACATTTTTAGATACTCTGACAGGCCACTGCATCTCAGATTCAGGGGAGAAAATAA
GTTGTCACCTCCCCTTCAAAGTTCCAGAGTAAACAAATGGTGCCATCATTCAAGATAACATGCTGATCACCCTCCTCCCAAAAAGCAAGA
GCTTGTTTATGGCTGAGGAATCGGCGGATTGTCTGAATGACACATATACAGAGCCCCCACGGATTTCTGCACACTCTGGGTCTGTGCTGG
TGGAACATTGCCAATCAGTTCTTAATGAGGCACCTGTGTGTAAATACATGCTTGGTCTTCTCTGCAGAGAACTGAGGCTAAACTCTGTCC
CTACTTCTGGTTTTGCCCTGTCATGTCGTAACGAGGTGGGCCTTTTGAGGCCATTTTAGTTTGAGTTCGAGCCAACCACCTCTGTTGGTT

>91269_91269_1_TM9SF4-COMMD7_TM9SF4_chr20_30749168_ENST00000217315_COMMD7_chr20_31315949_ENST00000278980_length(amino acids)=812AA_BP=640
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVL
VYAIFYFVNKQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATY
FSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSMEC

--------------------------------------------------------------
>91269_91269_2_TM9SF4-COMMD7_TM9SF4_chr20_30749168_ENST00000217315_COMMD7_chr20_31315949_ENST00000446419_length(transcript)=3263nt_BP=2068nt
CCAAGATGGCGACGGCGATGGTGAGTGAAGGAGACTCCGGGAGCGGGAGCTGGAGCGGGGCCCTCCGGGGTATCCCAGGATCTTCCAGCA
CCCCATGCCTGGCCCTGAGCCACCTCCGGGACCCCTGACTCAGGCCTGAGGGCTACCTCTGACTGGGCTTGTCTTCCCCGAAATCCACCT
CCCTGGCCCTGCCCCTGCACTCAGGCTTGTGAAGGCCCCGAGTTTTGGGGGAGGCGCCGTTTCGGAGGAAGACCTCGGCTGCTGCCTTCG
CCGGTTCCCATTCTACTTTTGGTCTCCGCCCACTGATTGGTTGCCGTGGTCTTTACTGCTTTTCTCCCTGATGTGTGAAACAAGCGCCTT
CTATGTGCCTGGGGTCGCGCCTATCAACTTCCACCAGAACGATCCCGTAGAAATCAAGGCTGTGAAGCTCACCAGCTCTCGAACCCAGCT
ACCTTATGAATACTATTCACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAAGGCAGAGAATCTGGGAGAGGTGCTGAGAGGGGACCG
GATTGTCAACACCCCTTTCCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGTTCTGTGCAGCCAGTCCAACAAGCCAGTGACCCTGAC
AGTGGAGCAGAGCCGACTCGTGGCCGAGCGGATCACAGAAGACTACTACGTCCACCTCATTGCTGACAACCTGCCTGTGGCCACCCGGCT
GGAGCTCTACTCCAACCGAGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCAGTTTGAACACGGCTACCGGCTCGGCTTCACAGATGT
CAACAAGATCTACCTGCACAACCACCTCTCATTCATCCTTTACTATCATCGGGAGGACATGGAAGAGGACCAGGAGCACACGTACCGTGT
CGTCCGCTTCGAGGTGATTCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGATGAGAAGAGTTCGTGCACTCTGCCTGAGGGTACCAA
CTCCTCGCCCCAAGAAATTGACCCCACCAAGGAGAATCAGCTGTACTTCACCTACTCTGTCCACTGGGAGGAAAGTGATATCAAATGGGC
CTCTCGCTGGGACACTTACCTGACCATGAGTGACGTCCAGATCCACTGGTTTTCTATCATTAACTCCGTTGTTGTGGTCTTCTTCCTGTC
AGGTATCCTGAGCATGATTATCATTCGGACCCTCCGGAAGGACATTGCCAACTACAACAAGGAGGATGACATTGAAGACACCATGGAGGA
GTCTGGGTGGAAGTTGGTGCACGGCGACGTCTTCAGGCCCCCCCAGTACCCCATGATCCTCAGCTCCCTGCTGGGCTCAGGCATTCAGCT
GTTCTGTATGATCCTCATCGTCATCTTTGTAGCCATGCTTGGGATGCTGTCGCCCTCCAGCCGGGGAGCTCTCATGACCACAGCCTGCTT
CCTCTTCATGTTCATGGGGGTGTTTGGCGGATTTTCTGCTGGCCGTCTGTACCGCACTTTAAAAGGCCATCGGTGGAAGAAAGGAGCCTT
CTGTACGGCAACTCTGTACCCTGGTGTGGTTTTTGGCATCTGCTTCGTATTGAATTGCTTCATTTGGGGAAAGCACTCATCAGGAGCGGT
GCCCTTTCCCACCATGGTGGCTCTGCTGTGCATGTGGTTCGGGATCTCCCTGCCCCTCGTCTACTTGGGCTACTACTTCGGCTTCCGAAA
GCAGCCATATGACAACCCTGTGCGCACCAACCAGATTCCCCGGCAGATCCCCGAGCAGCGGTGGTACATGAACCGATTTGTGGGCATCCT
CATGGCTGGGATCTTGCCCTTCGGCGCCATGTTCATCGAGCTCTTCTTCATCTTCAGTGCTATCTGGGAGAATCAGTTCTATTACCTCTT
TGGCTTCCTGTTCCTTGTTTTCATCATCCTGGTGGTATCCTGTTCACAAATCAGCATCGTCATGGTGTACTTCCAGCTGTGTGCAGAGGA
TTACCGCTGGTGGTGGAGAAATTTCCTAGTCTCCGGGGGCTCTGCATTCTACGTCCTGGTTTATGCCATCTTTTATTTCGTTAACAAGTT
CTCAGCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGTGGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCAC
CAATCAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCTGGTTCCAAATGGTGCTTTGAAGAAGAGTCTCACAGCCAA
GCAGGTCCAGGCGGATTTCATAACTCTGGGTCTTAGTGAGGAGAAAGCCACTTACTTTTCTGAAAAGTGGAAGCAGAATGCTCCCACCCT
TGCTCGATGGGCCATAGGTCAGACTCTGATGATTAACCAGCTCATAGATATGGAGTGGAAATTTGGAGTGACATCTGGGAGCAGCGAATT
GGAGAAAGTGGGAAGTATATTTTTACAACTAAAGTTGGTGGTTAAGAAAGGAAATCAAACCGAAAATGTGTATATAGAATTAACCTTGCC
TCAGTTCTACAGCTTCCTGCACGAGATGGAGCGAGTCAGAACCAGCATGGAGTGTTTCTGCTGATTTCTGTCCCTGCATCTCCCCTGGCC
CCGTTCCCTGCCCTCCTCCCTTCCCTGGGTGACTGCTCTGAGAGGCACTTCACTCACAGGCCTGTGGGATGCTCCATGGGGCCCTGCTGG
CTCCATGGGGCCCAGGTGCAAAGGGTTTCTGAAAAACAGCAGGATTAAGTACTGAAAGAGCCCAACACAATTACCCTGTAAACTCTCTGT
TAGGGCAACCACCACCACCTGTCTTCCAGGACACATTTTTAGATACTCTGACAGGCCACTGCATCTCAGATTCAGGGGAGAAAATAAGTT
GTCACCTCCCCTTCAAAGTTCCAGAGTAAACAAATGGTGCCATCATTCAAGATAACATGCTGATCACCCTCCTCCCAAAAAGCAAGAGCT
TGTTTATGGCTGAGGAATCGGCGGATTGTCTGAATGACACATATACAGAGCCCCCACGGATTTCTGCACACTCTGGGTCTGTGCTGGTGG
AACATTGCCAATCAGTTCTTAATGAGGCACCTGTGTGTAAATACATGCTTGGTCTTCTCTGCAGAGAACTGAGGCTAAACTCTGTCCCTA
CTTCTGGTTTTGCCCTGTCATGTCGTAACGAGGTGGGCCTTTTGAGGCCATTTTAGTTTGAGTTCGAGCCAACCACCTCTGTTGGTTAGA

>91269_91269_2_TM9SF4-COMMD7_TM9SF4_chr20_30749168_ENST00000217315_COMMD7_chr20_31315949_ENST00000446419_length(amino acids)=811AA_BP=640
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN
KEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRT
LKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQ
RWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVL
VYAIFYFVNKFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLGSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYF
SEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSIFLQLKLVVKKGNQTENVYIELTLPQFYSFLHEMERVRTSMECF

--------------------------------------------------------------
>91269_91269_3_TM9SF4-COMMD7_TM9SF4_chr20_30749168_ENST00000398022_COMMD7_chr20_31315949_ENST00000278980_length(transcript)=3224nt_BP=2014nt
AGTTTCTGCCAGGAGCTAATATGGCTTCCTTAGTTACACCGTTCTCTCTCTTCACCTAATCAGCGACCTTACTTTCCCAGACCAGACTGT
CGAGCAGGAGCTAAGACTCCTTTTCCCCTCTGCTGACCGCCACTACAGGAGCGGTTGAAGCCAGACGACCACCTTGTGGAGTTAAACTCC
GTAACCAGGGAGCACCACTTCCGCTGACGTCATTACGGCGACACGTGGATCCAAGATGGCGACGGCGATGGATTGGTTGCCGTGGTCTTT
ACTGCTTTTCTCCCTGATGTGTGAAACAAGCGCCTTCTATGTGCCTGGGGTCGCGCCTATCAACTTCCACCAGAACGATCCCGTAGAAAT
CAAGGCTGTGAAGCTCACCAGCTCTCGAACCCAGCTACCTTATGAATACTATTCACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAA
GGCAGAGAATCTGGGAGAGGTGCTGAGAGGGGACCGGATTGTCAACACCCCTTTCCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGT
TCTGTGCAGCCAGTCCAACAAGCCAGTGACCCTGACAGTGGAGCAGAGCCGACTCGTGGCCGAGCGGATCACAGAAGACTACTACGTCCA
CCTCATTGCTGACAACCTGCCTGTGGCCACCCGGCTGGAGCTCTACTCCAACCGAGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCA
GTTTGAACACGGCTACCGGCTCGGCTTCACAGATGTCAACAAGATCTACCTGCACAACCACCTCTCATTCATCCTTTACTATCATCGGGA
GGACATGGAAGAGGACCAGGAGCACACGTACCGTGTCGTCCGCTTCGAGGTGATTCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGA
TGAGAAGAGTTCGTGCACTCTGCCTGAGGGTACCAACTCCTCGCCCCAAGAAATTGACCCCACCAAGGAGAATCAGCTGTACTTCACCTA
CTCTGTCCACTGGGAGGAAAGTGATATCAAATGGGCCTCTCGCTGGGACACTTACCTGACCATGAGTGACGTCCAGATCCACTGGTTTTC
TATCATTAACTCCGTTGTTGTGGTCTTCTTCCTGTCAGGTATCCTGAGCATGATTATCATTCGGACCCTCCGGAAGGACATTGCCAACTA
CAACAAGGAGGATGACATTGAAGACACCATGGAGGAGTCTGGGTGGAAGTTGGTGCACGGCGACGTCTTCAGGCCCCCCCAGTACCCCAT
GATCCTCAGCTCCCTGCTGGGCTCAGGCATTCAGCTGTTCTGTATGATCCTCATCGTCATCTTTGTAGCCATGCTTGGGATGCTGTCGCC
CTCCAGCCGGGGAGCTCTCATGACCACAGCCTGCTTCCTCTTCATGTTCATGGGGGTGTTTGGCGGATTTTCTGCTGGCCGTCTGTACCG
CACTTTAAAAGGCCATCGGTGGAAGAAAGGAGCCTTCTGTACGGCAACTCTGTACCCTGGTGTGGTTTTTGGCATCTGCTTCGTATTGAA
TTGCTTCATTTGGGGAAAGCACTCATCAGGAGCGGTGCCCTTTCCCACCATGGTGGCTCTGCTGTGCATGTGGTTCGGGATCTCCCTGCC
CCTCGTCTACTTGGGCTACTACTTCGGCTTCCGAAAGCAGCCATATGACAACCCTGTGCGCACCAACCAGATTCCCCGGCAGATCCCCGA
GCAGCGGTGGTACATGAACCGATTTGTGGGCATCCTCATGGCTGGGATCTTGCCCTTCGGCGCCATGTTCATCGAGCTCTTCTTCATCTT
CAGTGCTATCTGGGAGAATCAGTTCTATTACCTCTTTGGCTTCCTGTTCCTTGTTTTCATCATCCTGGTGGTATCCTGTTCACAAATCAG
CATCGTCATGGTGTACTTCCAGCTGTGTGCAGAGGATTACCGCTGGTGGTGGAGAAATTTCCTAGTCTCCGGGGGCTCTGCATTCTACGT
CCTGGTTTATGCCATCTTTTATTTCGTTAACAAGCAGTTCTCAGCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGT
GGAAAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCT
GGTTCCAAATGGTGCTTTGAAGAAGAGTCTCACAGCCAAGCAGGTCCAGGCGGATTTCATAACTCTGGGTCTTAGTGAGGAGAAAGCCAC
TTACTTTTCTGAAAAGTGGAAGCAGAATGCTCCCACCCTTGCTCGATGGGCCATAGGTCAGACTCTGATGATTAACCAGCTCATAGATAT
GGAGTGGAAATTTGGAGTGACATCTGGGAGCAGCGAATTGGAGAAAGTGGGAAGTATATTTTTACAACTAAAGTTGGTGGTTAAGAAAGG
AAATCAAACCGAAAATGTGTATATAGAATTAACCTTGCCTCAGTTCTACAGCTTCCTGCACGAGATGGAGCGAGTCAGAACCAGCATGGA
GTGTTTCTGCTGATTTCTGTCCCTGCATCTCCCCTGGCCCCGTTCCCTGCCCTCCTCCCTTCCCTGGGTGACTGCTCTGAGAGGCACTTC
ACTCACAGGCCTGTGGGATGCTCCATGGGGCCCTGCTGGCTCCATGGGGCCCAGGTGCAAAGGGTTTCTGAAAAACAGCAGGATTAAGTA
CTGAAAGAGCCCAACACAATTACCCTGTAAACTCTCTGTTAGGGCAACCACCACCACCTGTCTTCCAGGACACATTTTTAGATACTCTGA
CAGGCCACTGCATCTCAGATTCAGGGGAGAAAATAAGTTGTCACCTCCCCTTCAAAGTTCCAGAGTAAACAAATGGTGCCATCATTCAAG
ATAACATGCTGATCACCCTCCTCCCAAAAAGCAAGAGCTTGTTTATGGCTGAGGAATCGGCGGATTGTCTGAATGACACATATACAGAGC
CCCCACGGATTTCTGCACACTCTGGGTCTGTGCTGGTGGAACATTGCCAATCAGTTCTTAATGAGGCACCTGTGTGTAAATACATGCTTG
GTCTTCTCTGCAGAGAACTGAGGCTAAACTCTGTCCCTACTTCTGGTTTTGCCCTGTCATGTCGTAACGAGGTGGGCCTTTTGAGGCCAT

>91269_91269_3_TM9SF4-COMMD7_TM9SF4_chr20_30749168_ENST00000398022_COMMD7_chr20_31315949_ENST00000278980_length(amino acids)=765AA_BP=593
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV
FIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKQFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISL
GSLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGS

--------------------------------------------------------------
>91269_91269_4_TM9SF4-COMMD7_TM9SF4_chr20_30749168_ENST00000398022_COMMD7_chr20_31315949_ENST00000446419_length(transcript)=3209nt_BP=2014nt
AGTTTCTGCCAGGAGCTAATATGGCTTCCTTAGTTACACCGTTCTCTCTCTTCACCTAATCAGCGACCTTACTTTCCCAGACCAGACTGT
CGAGCAGGAGCTAAGACTCCTTTTCCCCTCTGCTGACCGCCACTACAGGAGCGGTTGAAGCCAGACGACCACCTTGTGGAGTTAAACTCC
GTAACCAGGGAGCACCACTTCCGCTGACGTCATTACGGCGACACGTGGATCCAAGATGGCGACGGCGATGGATTGGTTGCCGTGGTCTTT
ACTGCTTTTCTCCCTGATGTGTGAAACAAGCGCCTTCTATGTGCCTGGGGTCGCGCCTATCAACTTCCACCAGAACGATCCCGTAGAAAT
CAAGGCTGTGAAGCTCACCAGCTCTCGAACCCAGCTACCTTATGAATACTATTCACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAA
GGCAGAGAATCTGGGAGAGGTGCTGAGAGGGGACCGGATTGTCAACACCCCTTTCCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGT
TCTGTGCAGCCAGTCCAACAAGCCAGTGACCCTGACAGTGGAGCAGAGCCGACTCGTGGCCGAGCGGATCACAGAAGACTACTACGTCCA
CCTCATTGCTGACAACCTGCCTGTGGCCACCCGGCTGGAGCTCTACTCCAACCGAGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCA
GTTTGAACACGGCTACCGGCTCGGCTTCACAGATGTCAACAAGATCTACCTGCACAACCACCTCTCATTCATCCTTTACTATCATCGGGA
GGACATGGAAGAGGACCAGGAGCACACGTACCGTGTCGTCCGCTTCGAGGTGATTCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGA
TGAGAAGAGTTCGTGCACTCTGCCTGAGGGTACCAACTCCTCGCCCCAAGAAATTGACCCCACCAAGGAGAATCAGCTGTACTTCACCTA
CTCTGTCCACTGGGAGGAAAGTGATATCAAATGGGCCTCTCGCTGGGACACTTACCTGACCATGAGTGACGTCCAGATCCACTGGTTTTC
TATCATTAACTCCGTTGTTGTGGTCTTCTTCCTGTCAGGTATCCTGAGCATGATTATCATTCGGACCCTCCGGAAGGACATTGCCAACTA
CAACAAGGAGGATGACATTGAAGACACCATGGAGGAGTCTGGGTGGAAGTTGGTGCACGGCGACGTCTTCAGGCCCCCCCAGTACCCCAT
GATCCTCAGCTCCCTGCTGGGCTCAGGCATTCAGCTGTTCTGTATGATCCTCATCGTCATCTTTGTAGCCATGCTTGGGATGCTGTCGCC
CTCCAGCCGGGGAGCTCTCATGACCACAGCCTGCTTCCTCTTCATGTTCATGGGGGTGTTTGGCGGATTTTCTGCTGGCCGTCTGTACCG
CACTTTAAAAGGCCATCGGTGGAAGAAAGGAGCCTTCTGTACGGCAACTCTGTACCCTGGTGTGGTTTTTGGCATCTGCTTCGTATTGAA
TTGCTTCATTTGGGGAAAGCACTCATCAGGAGCGGTGCCCTTTCCCACCATGGTGGCTCTGCTGTGCATGTGGTTCGGGATCTCCCTGCC
CCTCGTCTACTTGGGCTACTACTTCGGCTTCCGAAAGCAGCCATATGACAACCCTGTGCGCACCAACCAGATTCCCCGGCAGATCCCCGA
GCAGCGGTGGTACATGAACCGATTTGTGGGCATCCTCATGGCTGGGATCTTGCCCTTCGGCGCCATGTTCATCGAGCTCTTCTTCATCTT
CAGTGCTATCTGGGAGAATCAGTTCTATTACCTCTTTGGCTTCCTGTTCCTTGTTTTCATCATCCTGGTGGTATCCTGTTCACAAATCAG
CATCGTCATGGTGTACTTCCAGCTGTGTGCAGAGGATTACCGCTGGTGGTGGAGAAATTTCCTAGTCTCCGGGGGCTCTGCATTCTACGT
CCTGGTTTATGCCATCTTTTATTTCGTTAACAAGTTCTCAGCCCTGACAGAGGTGCTTTTCCACTTCCTAACTGAGCCAAAAGAGGTGGA
AAGATTTCTGGCTCAGCTCTCTGAATTTGCCACCACCAATCAGATCAGTCTTGGCTCCCTCAGAAGCATCGTGAAAAGCCTCCTTCTGGT
TCCAAATGGTGCTTTGAAGAAGAGTCTCACAGCCAAGCAGGTCCAGGCGGATTTCATAACTCTGGGTCTTAGTGAGGAGAAAGCCACTTA
CTTTTCTGAAAAGTGGAAGCAGAATGCTCCCACCCTTGCTCGATGGGCCATAGGTCAGACTCTGATGATTAACCAGCTCATAGATATGGA
GTGGAAATTTGGAGTGACATCTGGGAGCAGCGAATTGGAGAAAGTGGGAAGTATATTTTTACAACTAAAGTTGGTGGTTAAGAAAGGAAA
TCAAACCGAAAATGTGTATATAGAATTAACCTTGCCTCAGTTCTACAGCTTCCTGCACGAGATGGAGCGAGTCAGAACCAGCATGGAGTG
TTTCTGCTGATTTCTGTCCCTGCATCTCCCCTGGCCCCGTTCCCTGCCCTCCTCCCTTCCCTGGGTGACTGCTCTGAGAGGCACTTCACT
CACAGGCCTGTGGGATGCTCCATGGGGCCCTGCTGGCTCCATGGGGCCCAGGTGCAAAGGGTTTCTGAAAAACAGCAGGATTAAGTACTG
AAAGAGCCCAACACAATTACCCTGTAAACTCTCTGTTAGGGCAACCACCACCACCTGTCTTCCAGGACACATTTTTAGATACTCTGACAG
GCCACTGCATCTCAGATTCAGGGGAGAAAATAAGTTGTCACCTCCCCTTCAAAGTTCCAGAGTAAACAAATGGTGCCATCATTCAAGATA
ACATGCTGATCACCCTCCTCCCAAAAAGCAAGAGCTTGTTTATGGCTGAGGAATCGGCGGATTGTCTGAATGACACATATACAGAGCCCC
CACGGATTTCTGCACACTCTGGGTCTGTGCTGGTGGAACATTGCCAATCAGTTCTTAATGAGGCACCTGTGTGTAAATACATGCTTGGTC
TTCTCTGCAGAGAACTGAGGCTAAACTCTGTCCCTACTTCTGGTTTTGCCCTGTCATGTCGTAACGAGGTGGGCCTTTTGAGGCCATTTT

>91269_91269_4_TM9SF4-COMMD7_TM9SF4_chr20_30749168_ENST00000398022_COMMD7_chr20_31315949_ENST00000446419_length(amino acids)=764AA_BP=593
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY
LTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILI
VIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMV
ALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLV
FIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKFSALTEVLFHFLTEPKEVERFLAQLSEFATTNQISLG
SLRSIVKSLLLVPNGALKKSLTAKQVQADFITLGLSEEKATYFSEKWKQNAPTLARWAIGQTLMINQLIDMEWKFGVTSGSSELEKVGSI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TM9SF4-COMMD7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TM9SF4-COMMD7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TM9SF4-COMMD7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source