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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TM9SF4-NKTR (FusionGDB2 ID:91274)

Fusion Gene Summary for TM9SF4-NKTR

Fusion gene summary

Fusion gene information	Fusion gene name: TM9SF4-NKTR
	Fusion gene ID: 91274
		Hgene	Tgene
	Gene symbol	TM9SF4	NKTR
	Gene ID	9777	4820
	Gene name	transmembrane 9 superfamily member 4	natural killer cell triggering receptor
	Synonyms	dJ836N17.2	p104
	Cytomap	20q11.21	3p22.1
	Type of gene	protein-coding	protein-coding
	Description	transmembrane 9 superfamily member 4dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4transmembrane 9 superfamily protein member 4tumor cannibalism associated protein 1	NK-tumor recognition proteinNK-TR proteinPPIasenatural killer triggering receptornatural killer-tumor recognition sequencenatural-killer cells cyclophilin-related proteinpeptidyl-prolyl cis-trans isomerase NKTRrotamase
	Modification date	20200313	20200313
	UniProtAcc	.	P30414
	Ensembl transtripts involved in fusion gene	ENST00000217315, ENST00000398022,	ENST00000442970, ENST00000460910, ENST00000232978,
Fusion gene scores	* DoF score	20 X 19 X 14=5320	2 X 2 X 2=8
	# samples	28	2
	** MAII score	log2(28/5320*10)=-4.24792751344359 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: TM9SF4 [Title/Abstract] AND NKTR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TM9SF4(30734652)-NKTR(42687441), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TM9SF4	GO:0001666	response to hypoxia	25961573
Tgene	NKTR	GO:0000413	protein peptidyl-prolyl isomerization	20676357

Fusion gene breakpoints across TM9SF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NKTR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AK302439	TM9SF4	chr20	30734652	+	NKTR	chr3	42687441	+

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Fusion Gene ORF analysis for TM9SF4-NKTR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000217315	ENST00000442970	TM9SF4	chr20	30734652	+	NKTR	chr3	42687441	+
5CDS-intron	ENST00000217315	ENST00000460910	TM9SF4	chr20	30734652	+	NKTR	chr3	42687441	+
5CDS-intron	ENST00000398022	ENST00000442970	TM9SF4	chr20	30734652	+	NKTR	chr3	42687441	+
5CDS-intron	ENST00000398022	ENST00000460910	TM9SF4	chr20	30734652	+	NKTR	chr3	42687441	+
In-frame	ENST00000217315	ENST00000232978	TM9SF4	chr20	30734652	+	NKTR	chr3	42687441	+
In-frame	ENST00000398022	ENST00000232978	TM9SF4	chr20	30734652	+	NKTR	chr3	42687441	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000398022

TM9SF4

chr20

30734652

ENST00000232978

NKTR

chr3

42687441

3975

1189

235

1248

337

ENST00000217315

TM9SF4

chr20

30734652

ENST00000232978

NKTR

chr3

42687441

4029

1243

148

1302

384

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398022	ENST00000232978	TM9SF4	chr20	30734652	+	NKTR	chr3	42687441	+	0.000216733	0.99978334
ENST00000217315	ENST00000232978	TM9SF4	chr20	30734652	+	NKTR	chr3	42687441	+	0.000356215	0.9996438

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Fusion Genomic Features for TM9SF4-NKTR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TM9SF4-NKTR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:30734652/chr3:42687441)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NKTR P30414
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688). {ECO:0000269\|PubMed:20676357, ECO:0000269\|PubMed:8421688}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

24_281

301

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

24_281

318

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

282_302

301

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

282_302

318

643.0

Transmembrane

Helical

Tgene

NKTR

chr20:30734652

chr3:42687441

ENST00000232978

194_244

1463.0

Compositional bias

Note=Arg/Ser-rich

Tgene

NKTR

chr20:30734652

chr3:42687441

ENST00000232978

219_240

1463.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

NKTR

chr20:30734652

chr3:42687441

ENST00000232978

421_457

1463.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

NKTR

chr20:30734652

chr3:42687441

ENST00000232978

466_574

1463.0

Compositional bias

Note=Arg/Ser-rich

Tgene

NKTR

chr20:30734652

chr3:42687441

ENST00000232978

664_814

1463.0

Compositional bias

Note=Arg/Ser-rich

Tgene

NKTR

chr20:30734652

chr3:42687441

ENST00000232978

970_1010

1463.0

Compositional bias

Note=Arg/Lys-rich (basic)

Tgene

NKTR

chr20:30734652

chr3:42687441

ENST00000232978

10_175

1463.0

Domain

PPIase cyclophilin-type

Tgene

NKTR

chr20:30734652

chr3:42687441

ENST00000232978

1311_1348

1463.0

Region

Note=Arg/Ser tandem repeat-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

303_346

301

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

368_376

301

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

398_416

301

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

438_449

301

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

471_501

301

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

523_535

301

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

557_570

301

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

592_598

301

626.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

620_642

301

626.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

303_346

318

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

368_376

318

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

398_416

318

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

438_449

318

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

471_501

318

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

523_535

318

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

557_570

318

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

592_598

318

643.0

Topological domain

Extracellular

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

620_642

318

643.0

Topological domain

Cytoplasmic

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

347_367

301

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

377_397

301

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

417_437

301

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

450_470

301

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

502_522

301

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

536_556

301

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

571_591

301

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000217315

599_619

301

626.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

347_367

318

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

377_397

318

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

417_437

318

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

450_470

318

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

502_522

318

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

536_556

318

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

571_591

318

643.0

Transmembrane

Helical

Hgene

TM9SF4

chr20:30734652

chr3:42687441

ENST00000398022

599_619

318

643.0

Transmembrane

Helical

Top

Fusion Gene Sequence for TM9SF4-NKTR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91274_91274_1_TM9SF4-NKTR_TM9SF4_chr20_30734652_ENST00000217315_NKTR_chr3_42687441_ENST00000232978_length(transcript)=4029nt_BP=1243nt
CCAAGATGGCGACGGCGATGGTGAGTGAAGGAGACTCCGGGAGCGGGAGCTGGAGCGGGGCCCTCCGGGGTATCCCAGGATCTTCCAGCA
CCCCATGCCTGGCCCTGAGCCACCTCCGGGACCCCTGACTCAGGCCTGAGGGCTACCTCTGACTGGGCTTGTCTTCCCCGAAATCCACCT
CCCTGGCCCTGCCCCTGCACTCAGGCTTGTGAAGGCCCCGAGTTTTGGGGGAGGCGCCGTTTCGGAGGAAGACCTCGGCTGCTGCCTTCG
CCGGTTCCCATTCTACTTTTGGTCTCCGCCCACTGATTGGTTGCCGTGGTCTTTACTGCTTTTCTCCCTGATGTGTGAAACAAGCGCCTT
CTATGTGCCTGGGGTCGCGCCTATCAACTTCCACCAGAACGATCCCGTAGAAATCAAGGCTGTGAAGCTCACCAGCTCTCGAACCCAGCT
ACCTTATGAATACTATTCACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAAGGCAGAGAATCTGGGAGAGGTGCTGAGAGGGGACCG
GATTGTCAACACCCCTTTCCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGTTCTGTGCAGCCAGTCCAACAAGCCAGTGACCCTGAC
AGTGGAGCAGAGCCGACTCGTGGCCGAGCGGATCACAGAAGACTACTACGTCCACCTCATTGCTGACAACCTGCCTGTGGCCACCCGGCT
GGAGCTCTACTCCAACCGAGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCAGTTTGAACACGGCTACCGGCTCGGCTTCACAGATGT
CAACAAGATCTACCTGCACAACCACCTCTCATTCATCCTTTACTATCATCGGGAGGACATGGAAGAGGACCAGGAGCACACGTACCGTGT
CGTCCGCTTCGAGGTGATTCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGATGAGAAGAGTTCGTGCACTCTGCCTGAGGGTACCAA
CTCCTCGCCCCAAGAAATTGACCCCACCAAGGAGAATCAGCTGTACTTCACCTACTCTGTCCACTGGGAGGAAAGTGATATCAAATGGGC
CTCTCGCTGGGACACTTACCTGACCATGAGTGACGTCCAGATCCACTGGTTTTCTATCATTAACTCCGTTGTTGTGGTCTTCTTCCTGTC
AGGTATCCTGAGCATGATTATCATTCGGACCCTCCGGAAGGACATTGCCAACTACAACAAGGAGGATGACATTCCAGTGAGAGCAGCAGA
TACAGTTGAAAACGTCCGGATACAAATTATATCTTATTTGTAAATATCTGGCAACTTAGCTTAAGAAATGTAATGACAGTCTGTTGTTCT
ATTTCAATATCAGAGGTGAATTTCAAAAATAGACACTTCTTAATTGTTACTGGTTCATTTACATGTGGGGAGAAGAATTTAAAATACAGA
TATGTCTCCTAAAAATATTTTTATGCCACATTTTACAGTAGCCAACTATGGAAATGAATTTCATTTTCTTGAATCAAGAAATCGTGAAAT
TTATCTATGTATAATTTGCAATATTATTTTAAGTCTATTTCACTCTATCTTACGTATCCCTTAGAATACAGATTCTTTTTGCCTGTTTTT
CCAGTTTTAGCATATATGCTGCCAAGCATAGAACTGTGAAGGAGAACTGTTAAAGGCGGCCAAATATTTATATACTGATTACATAGAGTC
TTGTACATATGTGCTCTAAAAACAAACCACCCAGAATTGATACTGTTGGTAACCAGGAGTATAAGGCAGTGGCTCTGGGGTTCTTAATTC
ATTCCTAACTTCTTTGATACTTCACAGGATTAGGAAAGTGGTCATCATACATCCCACACAGTCTGTATTACTTCAGGCTTGTGGGCAAGG
TTAGGAAGAATCAATCAGCCTTAACTATAAATACCTGCACTGTCTCTGAGGACTTACTATTTTATGTTCTTTTTAATCAATACCGATCAG
AAGTTTAGGTTATAAAAACAATTCTACTTCATGCTTTGGTGCTTGGTAATTTTTGGTGCGTCTTTAAGCATTACTCTTATATATCATATA
TTAAAATACCATAAAAATGAAATTCAGACAAAATCACTGGCACCAAAAATGGTTTATTCTGAGCTGTCTTCACTTTGACTATTTGGGGGG
CTTCTCTCAAGTACAGATGTGGGTTGGGGTCCCCTGGAGCAGGCAGGATTGGCAGTAAGAGATATTGGCCACTCAAGTCTACTGTGTGTG
TGTGCCTCTGGAAGAGTGAAGAATGGACTTCAAAAGTAACATCAAAAATCTAACTGCCACCATCCTGGAGACATTTTGCAGGGCTTTCCT
TTCAAGTCTTTCAAGTACAGGATATTACCACAACAGCAGCTGAACTGTTGTAACCAGCATGTTTTTCCTATTTCCACTGTGACCTGCAGC
TGACTCAAAGCCTTGCGTGACCTGACCCAGGTGCAAGAGACAGGGGAAGAGGGATAGAGGGTATAGCATAAATTACATATTTTCATGGCT
TTGGGTGGTTCCTCCAAAAATAATTGGACCTGTAAAAACTAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGGTTTTTTTTTTTAA
TCTTTACTTTGAATTTGTTCCCCAAGTGTACTTAATCACCTTAGTGCCAGTTTAATCCAGTTATGCAGAAGAAATTCATATTGGTTGCCT
GATGTAGAGCTCAGCACCACCCTACCACAGGCCTTGTCTGGTGTATTTGGGAAGTGGAAAAGAGCCCTCAGTTGGAGGGAGCTGACAACC
CTTGGTGGAGGGAGGGTGCCCTTGAATGTATTAAAACTATCACCCAAAGAAGGTATGAAAACAGGGTAAGGTGGTCAGTTGTTTGCCAGG
TCAATAGACAGAAAGTACATTAGAAAACAGGACTTAGGCCAAACAAACAATACTGGATACTGAATACAAAACAGTATGATTTATATTAAA
GGTTTCCAAAGGTTGCCTGCAAAGGAGAATATTACTACTAGTCAGCAGGAAAAAAATGCATTCAGAACCCAAGCAGAAACTGCCAAATGT
AATTAGGTTAAGAAAAGTTACCCTTGGGCAGTGTATTAGTTTTCTATTGCTGTGTGACAAATTACCCCAAATTTAGCAGTTTAAAAAACA
ATACCCATAGCAGTTCTGTAGCTCATGAGTCTGGCACAGTGTGGCTGGATTCTCTGCTCAGGGTCTTAAAGGCTGAAATAAGGGTTGGCA
GGACAACATTCCTTCATGGAGGCTCTGGGGAAGAATCTGCTTCTAAGTTCATTCAGGTTGTTGGCGGAATTCAGTTCTTTGCTGGCTCTC
AGCTGGAGGCCCCTCTCTCACCTCAAGGCTGCCTGCATTCCTTCTTATGTGGTCCCCTCCAGCTTCAAACCAGCCTTCCTGCTCTTTCTC
ATGCTTCATATCTCTCTCCCGTCCTCCTGTTTTAGGGGCATATGATTAGCTCAAGCCCACAGATATATTTTAAGGTTGATTGTGCGATAG
AACATAATTGCAGGAGTACTGTCTCATCTCATCATATTCACGGGTTCTGGAGATTAGCTCATTGAAAGTGGGAGGGGCATTTTCAAATTC
TGCCTACCACAGGCAATAACTGCCCATCTCAGCTGTAGGTGGAATTTTTACCCAGAAAAGATAGGCCCTAGAAGCCTCATTTCTTTTCTC
CATGGAAAAGGACAGCCCTCTGCTGCAGCGTTCAACTTGTGTGTTTACTGACAGAGTGAACTACAGAAATAGCTTTTCTTCCTAAAGGGG
ATTGTTCTACATTTTGAAGTTATTTTTTAATAAAATTGAATTATGTTGTGTATTGTGCTTCTTAATAGGAAATGCATTATTGGACTGTTT
TTGTAACATCCTGTTTATTGCAAATAGCTAGTATCGTTCAAAAACTGTATAAAATACTTTTGTACATATTAGCAATGTCTAATTTGTATA

>91274_91274_1_TM9SF4-NKTR_TM9SF4_chr20_30734652_ENST00000217315_NKTR_chr3_42687441_ENST00000232978_length(amino acids)=384AA_BP=365
MTGLVFPEIHLPGPAPALRLVKAPSFGGGAVSEEDLGCCLRRFPFYFWSPPTDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIK
AVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHL
IADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADE
KSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYN

--------------------------------------------------------------
>91274_91274_2_TM9SF4-NKTR_TM9SF4_chr20_30734652_ENST00000398022_NKTR_chr3_42687441_ENST00000232978_length(transcript)=3975nt_BP=1189nt
AGTTTCTGCCAGGAGCTAATATGGCTTCCTTAGTTACACCGTTCTCTCTCTTCACCTAATCAGCGACCTTACTTTCCCAGACCAGACTGT
CGAGCAGGAGCTAAGACTCCTTTTCCCCTCTGCTGACCGCCACTACAGGAGCGGTTGAAGCCAGACGACCACCTTGTGGAGTTAAACTCC
GTAACCAGGGAGCACCACTTCCGCTGACGTCATTACGGCGACACGTGGATCCAAGATGGCGACGGCGATGGATTGGTTGCCGTGGTCTTT
ACTGCTTTTCTCCCTGATGTGTGAAACAAGCGCCTTCTATGTGCCTGGGGTCGCGCCTATCAACTTCCACCAGAACGATCCCGTAGAAAT
CAAGGCTGTGAAGCTCACCAGCTCTCGAACCCAGCTACCTTATGAATACTATTCACTGCCCTTCTGCCAGCCCAGCAAGATAACCTACAA
GGCAGAGAATCTGGGAGAGGTGCTGAGAGGGGACCGGATTGTCAACACCCCTTTCCAGGTTCTCATGAACAGCGAGAAGAAGTGTGAAGT
TCTGTGCAGCCAGTCCAACAAGCCAGTGACCCTGACAGTGGAGCAGAGCCGACTCGTGGCCGAGCGGATCACAGAAGACTACTACGTCCA
CCTCATTGCTGACAACCTGCCTGTGGCCACCCGGCTGGAGCTCTACTCCAACCGAGACAGCGATGACAAGAAGAAGGAAAAAGATGTGCA
GTTTGAACACGGCTACCGGCTCGGCTTCACAGATGTCAACAAGATCTACCTGCACAACCACCTCTCATTCATCCTTTACTATCATCGGGA
GGACATGGAAGAGGACCAGGAGCACACGTACCGTGTCGTCCGCTTCGAGGTGATTCCCCAGAGCATCAGGCTGGAGGACCTCAAAGCAGA
TGAGAAGAGTTCGTGCACTCTGCCTGAGGGTACCAACTCCTCGCCCCAAGAAATTGACCCCACCAAGGAGAATCAGCTGTACTTCACCTA
CTCTGTCCACTGGGAGGAAAGTGATATCAAATGGGCCTCTCGCTGGGACACTTACCTGACCATGAGTGACGTCCAGATCCACTGGTTTTC
TATCATTAACTCCGTTGTTGTGGTCTTCTTCCTGTCAGGTATCCTGAGCATGATTATCATTCGGACCCTCCGGAAGGACATTGCCAACTA
CAACAAGGAGGATGACATTCCAGTGAGAGCAGCAGATACAGTTGAAAACGTCCGGATACAAATTATATCTTATTTGTAAATATCTGGCAA
CTTAGCTTAAGAAATGTAATGACAGTCTGTTGTTCTATTTCAATATCAGAGGTGAATTTCAAAAATAGACACTTCTTAATTGTTACTGGT
TCATTTACATGTGGGGAGAAGAATTTAAAATACAGATATGTCTCCTAAAAATATTTTTATGCCACATTTTACAGTAGCCAACTATGGAAA
TGAATTTCATTTTCTTGAATCAAGAAATCGTGAAATTTATCTATGTATAATTTGCAATATTATTTTAAGTCTATTTCACTCTATCTTACG
TATCCCTTAGAATACAGATTCTTTTTGCCTGTTTTTCCAGTTTTAGCATATATGCTGCCAAGCATAGAACTGTGAAGGAGAACTGTTAAA
GGCGGCCAAATATTTATATACTGATTACATAGAGTCTTGTACATATGTGCTCTAAAAACAAACCACCCAGAATTGATACTGTTGGTAACC
AGGAGTATAAGGCAGTGGCTCTGGGGTTCTTAATTCATTCCTAACTTCTTTGATACTTCACAGGATTAGGAAAGTGGTCATCATACATCC
CACACAGTCTGTATTACTTCAGGCTTGTGGGCAAGGTTAGGAAGAATCAATCAGCCTTAACTATAAATACCTGCACTGTCTCTGAGGACT
TACTATTTTATGTTCTTTTTAATCAATACCGATCAGAAGTTTAGGTTATAAAAACAATTCTACTTCATGCTTTGGTGCTTGGTAATTTTT
GGTGCGTCTTTAAGCATTACTCTTATATATCATATATTAAAATACCATAAAAATGAAATTCAGACAAAATCACTGGCACCAAAAATGGTT
TATTCTGAGCTGTCTTCACTTTGACTATTTGGGGGGCTTCTCTCAAGTACAGATGTGGGTTGGGGTCCCCTGGAGCAGGCAGGATTGGCA
GTAAGAGATATTGGCCACTCAAGTCTACTGTGTGTGTGTGCCTCTGGAAGAGTGAAGAATGGACTTCAAAAGTAACATCAAAAATCTAAC
TGCCACCATCCTGGAGACATTTTGCAGGGCTTTCCTTTCAAGTCTTTCAAGTACAGGATATTACCACAACAGCAGCTGAACTGTTGTAAC
CAGCATGTTTTTCCTATTTCCACTGTGACCTGCAGCTGACTCAAAGCCTTGCGTGACCTGACCCAGGTGCAAGAGACAGGGGAAGAGGGA
TAGAGGGTATAGCATAAATTACATATTTTCATGGCTTTGGGTGGTTCCTCCAAAAATAATTGGACCTGTAAAAACTAGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTGGTTTTTTTTTTTAATCTTTACTTTGAATTTGTTCCCCAAGTGTACTTAATCACCTTAGTGCCAGTTTA
ATCCAGTTATGCAGAAGAAATTCATATTGGTTGCCTGATGTAGAGCTCAGCACCACCCTACCACAGGCCTTGTCTGGTGTATTTGGGAAG
TGGAAAAGAGCCCTCAGTTGGAGGGAGCTGACAACCCTTGGTGGAGGGAGGGTGCCCTTGAATGTATTAAAACTATCACCCAAAGAAGGT
ATGAAAACAGGGTAAGGTGGTCAGTTGTTTGCCAGGTCAATAGACAGAAAGTACATTAGAAAACAGGACTTAGGCCAAACAAACAATACT
GGATACTGAATACAAAACAGTATGATTTATATTAAAGGTTTCCAAAGGTTGCCTGCAAAGGAGAATATTACTACTAGTCAGCAGGAAAAA
AATGCATTCAGAACCCAAGCAGAAACTGCCAAATGTAATTAGGTTAAGAAAAGTTACCCTTGGGCAGTGTATTAGTTTTCTATTGCTGTG
TGACAAATTACCCCAAATTTAGCAGTTTAAAAAACAATACCCATAGCAGTTCTGTAGCTCATGAGTCTGGCACAGTGTGGCTGGATTCTC
TGCTCAGGGTCTTAAAGGCTGAAATAAGGGTTGGCAGGACAACATTCCTTCATGGAGGCTCTGGGGAAGAATCTGCTTCTAAGTTCATTC
AGGTTGTTGGCGGAATTCAGTTCTTTGCTGGCTCTCAGCTGGAGGCCCCTCTCTCACCTCAAGGCTGCCTGCATTCCTTCTTATGTGGTC
CCCTCCAGCTTCAAACCAGCCTTCCTGCTCTTTCTCATGCTTCATATCTCTCTCCCGTCCTCCTGTTTTAGGGGCATATGATTAGCTCAA
GCCCACAGATATATTTTAAGGTTGATTGTGCGATAGAACATAATTGCAGGAGTACTGTCTCATCTCATCATATTCACGGGTTCTGGAGAT
TAGCTCATTGAAAGTGGGAGGGGCATTTTCAAATTCTGCCTACCACAGGCAATAACTGCCCATCTCAGCTGTAGGTGGAATTTTTACCCA
GAAAAGATAGGCCCTAGAAGCCTCATTTCTTTTCTCCATGGAAAAGGACAGCCCTCTGCTGCAGCGTTCAACTTGTGTGTTTACTGACAG
AGTGAACTACAGAAATAGCTTTTCTTCCTAAAGGGGATTGTTCTACATTTTGAAGTTATTTTTTAATAAAATTGAATTATGTTGTGTATT
GTGCTTCTTAATAGGAAATGCATTATTGGACTGTTTTTGTAACATCCTGTTTATTGCAAATAGCTAGTATCGTTCAAAAACTGTATAAAA
TACTTTTGTACATATTAGCAATGTCTAATTTGTATACACTTCAGTTAAATTTCCCTAAAACTTGAAAGGGGACCTTGTAGAAATTAAAAT

>91274_91274_2_TM9SF4-NKTR_TM9SF4_chr20_30734652_ENST00000398022_NKTR_chr3_42687441_ENST00000232978_length(amino acids)=337AA_BP=318
MATAMDWLPWSLLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPF
QVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLH
NHLSFILYYHREDMEEDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTY

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Top

Fusion Gene PPI Analysis for TM9SF4-NKTR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TM9SF4-NKTR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TM9SF4-NKTR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source