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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMBIM4-BTBD10 (FusionGDB2 ID:91294)

Fusion Gene Summary for TMBIM4-BTBD10

check button Fusion gene summary
Fusion gene informationFusion gene name: TMBIM4-BTBD10
Fusion gene ID: 91294
HgeneTgene
Gene symbol

TMBIM4

BTBD10

Gene ID

51643

84280

Gene nametransmembrane BAX inhibitor motif containing 4BTB domain containing 10
SynonymsCGI-119|GAAP|LFG4|S1R|ZPROGMRP-1|GMRP1
Cytomap

12q14.3

11p15.3

Type of geneprotein-codingprotein-coding
Descriptionprotein lifeguard 4Golgi anti-apoptotic proteinZ-proteintransmembrane BAX inhibitor motif-containing protein 4BTB/POZ domain-containing protein 10BTB (POZ) domain containing 10BTB (broad-complex tramtrack and bric-a-brac/pox virus and zinc finger) domain-containing protein 10K+ channel tetramerization proteinepididymis secretory sperm binding proteinglucose
Modification date2020031320200327
UniProtAcc.

Q9BSF8

Ensembl transtripts involved in fusion geneENST00000286424, ENST00000358230, 
ENST00000398033, ENST00000539652, 
ENST00000542724, ENST00000556010, 
ENST00000544599, ENST00000535812, 
ENST00000528120, ENST00000532261, 
ENST00000278174, ENST00000530907, 
Fusion gene scores* DoF score14 X 8 X 8=8966 X 5 X 4=120
# samples 186
** MAII scorelog2(18/896*10)=-2.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMBIM4 [Title/Abstract] AND BTBD10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMBIM4(66539621)-BTBD10(13443386), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMBIM4

GO:0050848

regulation of calcium-mediated signaling

19553469


check buttonFusion gene breakpoints across TMBIM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BTBD10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABP320300TMBIM4chr12

66539621

-BTBD10chr11

13443386

-


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Fusion Gene ORF analysis for TMBIM4-BTBD10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000286424ENST00000528120TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000286424ENST00000532261TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000358230ENST00000528120TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000358230ENST00000532261TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000398033ENST00000528120TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000398033ENST00000532261TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000539652ENST00000528120TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000539652ENST00000532261TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000542724ENST00000528120TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000542724ENST00000532261TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000556010ENST00000528120TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5CDS-5UTRENST00000556010ENST00000532261TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5UTR-3CDSENST00000544599ENST00000278174TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5UTR-3CDSENST00000544599ENST00000530907TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5UTR-5UTRENST00000544599ENST00000528120TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
5UTR-5UTRENST00000544599ENST00000532261TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
Frame-shiftENST00000539652ENST00000278174TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
Frame-shiftENST00000539652ENST00000530907TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
Frame-shiftENST00000556010ENST00000278174TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
Frame-shiftENST00000556010ENST00000530907TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
In-frameENST00000286424ENST00000278174TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
In-frameENST00000286424ENST00000530907TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
In-frameENST00000358230ENST00000278174TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
In-frameENST00000358230ENST00000530907TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
In-frameENST00000398033ENST00000278174TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
In-frameENST00000398033ENST00000530907TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
In-frameENST00000542724ENST00000278174TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
In-frameENST00000542724ENST00000530907TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
intron-3CDSENST00000535812ENST00000278174TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
intron-3CDSENST00000535812ENST00000530907TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
intron-5UTRENST00000535812ENST00000528120TMBIM4chr12

66539621

-BTBD10chr11

13443386

-
intron-5UTRENST00000535812ENST00000532261TMBIM4chr12

66539621

-BTBD10chr11

13443386

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358230TMBIM4chr1266539621-ENST00000278174BTBD10chr1113443386-27425851211911596
ENST00000358230TMBIM4chr1266539621-ENST00000530907BTBD10chr1113443386-20605851211911596
ENST00000286424TMBIM4chr1266539621-ENST00000278174BTBD10chr1113443386-2773616111942643
ENST00000286424TMBIM4chr1266539621-ENST00000530907BTBD10chr1113443386-2091616111942643
ENST00000398033TMBIM4chr1266539621-ENST00000278174BTBD10chr1113443386-2668511471837596
ENST00000398033TMBIM4chr1266539621-ENST00000530907BTBD10chr1113443386-1986511471837596
ENST00000542724TMBIM4chr1266539621-ENST00000278174BTBD10chr1113443386-2659502651828587
ENST00000542724TMBIM4chr1266539621-ENST00000530907BTBD10chr1113443386-1977502651828587

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358230ENST00000278174TMBIM4chr1266539621-BTBD10chr1113443386-0.0011263750.99887365
ENST00000358230ENST00000530907TMBIM4chr1266539621-BTBD10chr1113443386-0.0022592440.99774075
ENST00000286424ENST00000278174TMBIM4chr1266539621-BTBD10chr1113443386-0.0017927120.99820733
ENST00000286424ENST00000530907TMBIM4chr1266539621-BTBD10chr1113443386-0.0039597490.9960402
ENST00000398033ENST00000278174TMBIM4chr1266539621-BTBD10chr1113443386-0.0011342640.9988657
ENST00000398033ENST00000530907TMBIM4chr1266539621-BTBD10chr1113443386-0.0025310450.99746895
ENST00000542724ENST00000278174TMBIM4chr1266539621-BTBD10chr1113443386-0.0010451640.9989548
ENST00000542724ENST00000530907TMBIM4chr1266539621-BTBD10chr1113443386-0.0024716830.9975284

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Fusion Genomic Features for TMBIM4-BTBD10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMBIM4-BTBD10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:66539621/chr11:13443386)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BTBD10

Q9BSF8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. {ECO:0000250|UniProtKB:Q80X66}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-57119_120154239.0Topological domainLumenal
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-57142_151154239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-571_38154239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-5760_68154239.0Topological domainLumenal
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-5790_97154239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-57121_141154239.0TransmembraneHelical
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-5739_59154239.0TransmembraneHelical
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-5769_89154239.0TransmembraneHelical
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-5798_118154239.0TransmembraneHelical
TgeneBTBD10chr12:66539621chr11:13443386ENST0000027817419106_14233476.0Compositional biasNote=Ser-rich
TgeneBTBD10chr12:66539621chr11:13443386ENST0000027817419167_24133476.0DomainNote=BTB

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-57209_229154239.0IntramembraneHelical
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-57173_175154239.0Topological domainLumenal
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-57197_208154239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-57230_238154239.0Topological domainCytoplasmic
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-57152_172154239.0TransmembraneHelical
HgeneTMBIM4chr12:66539621chr11:13443386ENST00000358230-57176_196154239.0TransmembraneHelical


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Fusion Gene Sequence for TMBIM4-BTBD10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91294_91294_1_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000286424_BTBD10_chr11_13443386_ENST00000278174_length(transcript)=2773nt_BP=616nt
CTGTTGCCATCATGGCTGACCCCGACCCCCGGTACCCTCGCTCCTCGATCGAGGACGACTTCAACTATGGCAGCAGCGTGGCCTCCGCCA
CCGTGCACATCCGAATGGTTCTCCAGAGAGATTGTACCTTCAGCAAACAATATATGAGGATACCTTCTGCACCCTCAGCCACACTGAATA
TCATCAGATTTTTTCATCTCCGGCAATCTGGTAGATCAGGGATGGTGAACATTTTCTACAAAGGGCCAACCTTTCTGAGAAAAGTCTACA
GCATTCTTTCTCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTC
CTGCCTTAATTTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACC
TACTTTTTGGATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATAC
TGACTACTACAGTATTTTTTGGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGTACTTCCTCGCGTA
TTGCTAAAGGAGGAGTTGACCACACCAAAATGAGTCTACATGGTGCTAGTGGGGGACATGAGAGATCAAGAGATAGACGAAGGTCAAGTG
ACAGATCACGAGATTCATCTCATGAAAGAACGGAGTCTCAGCTCACTCCTTGTATTAGAAATGTGACTTCTCCAACACGACAGCACCATG
TTGAACGAGAAAAAGATCACAGTTCCTCTCGTCCAAGCAGTCCGCGTCCTCAAAAAGCATCCCCAAATGGTTCCATTAGCAGTGCTGGGA
ACAGCAGCAGAAACAGTAGTCAGTCAAGTTCAGATGGTAGCTGTAAGACAGCTGGGGAGATGGTGTTTGTATATGAAAATGCAAAAGAAG
GAGCTCGGAATATAAGAACGTCAGAACGAGTGACACTAATAGTGGATAACACTAGATTTGTTGTAGACCCATCCATTTTTACTGCACAGC
CAAATACAATGTTGGGCAGGATGTTTGGATCTGGCCGAGAACATAACTTTACACGACCCAATGAGAAAGGAGAGTATGAGGTGGCAGAGG
GAATTGGTTCCACTGTGTTTCGAGCGATTCTGGATTACTATAAAACAGGAATAATCCGTTGTCCTGATGGCATATCTATTCCTGAACTGA
GAGAAGCATGTGACTATCTTTGTATCTCTTTTGAATATAGCACTATTAAATGTAGAGATCTCAGTGCCCTAATGCATGAGTTATCAAATG
ATGGTGCTCGTAGACAATTTGAATTTTATCTGGAAGAAATGATCCTCCCTCTCATGGTAGCTAGTGCCCAGAGTGGGGAACGGGAATGTC
ATATAGTGGTGCTTACAGATGATGATGTGGTTGATTGGGATGAAGAATATCCACCACAGATGGGAGAAGAATATTCACAAATTATTTATA
GCACAAAATTATATAGATTTTTCAAGTATATTGAAAACAGAGATGTGGCCAAGTCAGTTTTGAAGGAGAGGGGTCTTAAGAAGATTAGAT
TGGGAATAGAAGGTTATCCTACCTACAAAGAAAAAGTAAAGAAAAGGCCTGGAGGCCGCCCAGAAGTGATCTACAACTATGTCCAAAGAC
CCTTTATTCGAATGTCCTGGGAGAAGGAAGAAGGAAAGAGTCGGCATGTAGACTTTCAGTGTGTAAAGAGTAAATCTATCACCAATCTTG
CAGCAGCTGCAGCAGACATTCCCCAGGACCAGCTGGTAGTCATGCATCCAACTCCACAAGTGGATGAGCTGGATATTCTCCCTATCCATC
CCCCTTCTGGCAACAGTGACCTCGATCCTGATGCACAGAATCCAATGCTGTGATGCTGATCTTCCTTGAAACCATAGCATGCTACTCTTC
ACAGTGACGTTGTACTCTCCTCATTCTGCACTGCAAGGCCACTCTTCTTCATTGTGAGATGCACATAACAATGTTTAGGATATTGCAGTG
TAGGCTTTTTTAAAGACCAAAGGTAGCTGAATGGTTTTTTTTTAAATGAGTACAACTCTAGCATTTTGAAGTTCCAGTTGTAAATGTATT
TGTTTACCAGTAGGTTTGTGAAATTGGTTCTTTGTATGGGGGATGGTCCTTTTTCACACAGCTAGGTCTTTTCAGAAGTGGTGGAAATTG
GCAGCTGGGGTACTTTCAGTTTGGACTGATATTCATCACACCTCAGATAAAATGCAGAGTAATATATAGTTGCACTTTATAAATGGTGGT
TAAATGGAAATGTTCAAGCCATTTTATAGTTGTGATGCACAATATAATTTAAGTGCTTCTGTCAAAGTATTCCTCCAGTACAATTTGTAT
AGTTTGCTGCCCTTGATGAGCAAAAAGTATTTATCTTGGGCTTATCTGAATGATCAGGATGAGATTTAATGCCCATATCTTACCAGTTCA
GTTATCTCCAGAGCCATTTCACCCTTTAGAGTGAGTCACATGCAGGGAGTGTGAATGTCAGAGGTGGTTTATTATCCAGTCTGCCTTACC
CTTAATCTGTTCACAGATATTTATTTACTAATGCTTTTTTTTTCTTAAGAGTTATGGGATAGGAAAATGAAGTGTTTGCTCTTCATTTAC

>91294_91294_1_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000286424_BTBD10_chr11_13443386_ENST00000278174_length(amino acids)=643AA_BP=129
MADPDPRYPRSSIEDDFNYGSSVASATVHIRMVLQRDCTFSKQYMRIPSAPSATLNIIRFFHLRQSGRSGMVNIFYKGPTFLRKVYSILS
LQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTT
VFFGLTVYTLQSKKDFSKFGAGTSSRIAKGGVDHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERTESQLTPCIRNVTSPTRQHHVERE
KDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTAGEMVFVYENAKEGARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTM
LGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGAR
RQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIE
GYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPIHPPSG

--------------------------------------------------------------
>91294_91294_2_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000286424_BTBD10_chr11_13443386_ENST00000530907_length(transcript)=2091nt_BP=616nt
CTGTTGCCATCATGGCTGACCCCGACCCCCGGTACCCTCGCTCCTCGATCGAGGACGACTTCAACTATGGCAGCAGCGTGGCCTCCGCCA
CCGTGCACATCCGAATGGTTCTCCAGAGAGATTGTACCTTCAGCAAACAATATATGAGGATACCTTCTGCACCCTCAGCCACACTGAATA
TCATCAGATTTTTTCATCTCCGGCAATCTGGTAGATCAGGGATGGTGAACATTTTCTACAAAGGGCCAACCTTTCTGAGAAAAGTCTACA
GCATTCTTTCTCTGCAGGTTCTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTC
CTGCCTTAATTTTGCTGTTTGCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACC
TACTTTTTGGATTTACGCTGTTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATAC
TGACTACTACAGTATTTTTTGGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGTACTTCCTCGCGTA
TTGCTAAAGGAGGAGTTGACCACACCAAAATGAGTCTACATGGTGCTAGTGGGGGACATGAGAGATCAAGAGATAGACGAAGGTCAAGTG
ACAGATCACGAGATTCATCTCATGAAAGAACGGAGTCTCAGCTCACTCCTTGTATTAGAAATGTGACTTCTCCAACACGACAGCACCATG
TTGAACGAGAAAAAGATCACAGTTCCTCTCGTCCAAGCAGTCCGCGTCCTCAAAAAGCATCCCCAAATGGTTCCATTAGCAGTGCTGGGA
ACAGCAGCAGAAACAGTAGTCAGTCAAGTTCAGATGGTAGCTGTAAGACAGCTGGGGAGATGGTGTTTGTATATGAAAATGCAAAAGAAG
GAGCTCGGAATATAAGAACGTCAGAACGAGTGACACTAATAGTGGATAACACTAGATTTGTTGTAGACCCATCCATTTTTACTGCACAGC
CAAATACAATGTTGGGCAGGATGTTTGGATCTGGCCGAGAACATAACTTTACACGACCCAATGAGAAAGGAGAGTATGAGGTGGCAGAGG
GAATTGGTTCCACTGTGTTTCGAGCGATTCTGGATTACTATAAAACAGGAATAATCCGTTGTCCTGATGGCATATCTATTCCTGAACTGA
GAGAAGCATGTGACTATCTTTGTATCTCTTTTGAATATAGCACTATTAAATGTAGAGATCTCAGTGCCCTAATGCATGAGTTATCAAATG
ATGGTGCTCGTAGACAATTTGAATTTTATCTGGAAGAAATGATCCTCCCTCTCATGGTAGCTAGTGCCCAGAGTGGGGAACGGGAATGTC
ATATAGTGGTGCTTACAGATGATGATGTGGTTGATTGGGATGAAGAATATCCACCACAGATGGGAGAAGAATATTCACAAATTATTTATA
GCACAAAATTATATAGATTTTTCAAGTATATTGAAAACAGAGATGTGGCCAAGTCAGTTTTGAAGGAGAGGGGTCTTAAGAAGATTAGAT
TGGGAATAGAAGGTTATCCTACCTACAAAGAAAAAGTAAAGAAAAGGCCTGGAGGCCGCCCAGAAGTGATCTACAACTATGTCCAAAGAC
CCTTTATTCGAATGTCCTGGGAGAAGGAAGAAGGAAAGAGTCGGCATGTAGACTTTCAGTGTGTAAAGAGTAAATCTATCACCAATCTTG
CAGCAGCTGCAGCAGACATTCCCCAGGACCAGCTGGTAGTCATGCATCCAACTCCACAAGTGGATGAGCTGGATATTCTCCCTATCCATC
CCCCTTCTGGCAACAGTGACCTCGATCCTGATGCACAGAATCCAATGCTGTGATGCTGATCTTCCTTGAAACCATAGCATGCTACTCTTC
ACAGTGACGTTGTACTCTCCTCATTCTGCACTGCAAGGCCACTCTTCTTCATTGTGAGATGCACATAACAATGTTTAGGATATTGCAGTG

>91294_91294_2_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000286424_BTBD10_chr11_13443386_ENST00000530907_length(amino acids)=643AA_BP=129
MADPDPRYPRSSIEDDFNYGSSVASATVHIRMVLQRDCTFSKQYMRIPSAPSATLNIIRFFHLRQSGRSGMVNIFYKGPTFLRKVYSILS
LQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTT
VFFGLTVYTLQSKKDFSKFGAGTSSRIAKGGVDHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERTESQLTPCIRNVTSPTRQHHVERE
KDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTAGEMVFVYENAKEGARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTM
LGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGAR
RQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIE
GYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPIHPPSG

--------------------------------------------------------------
>91294_91294_3_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000358230_BTBD10_chr11_13443386_ENST00000278174_length(transcript)=2742nt_BP=585nt
CTCGCTCGGTGTTCGCCCGCCGACGCCGCACGGCTTGCTGGGGCTGGGCTCTTCCTCGCGGAAGTGGGGAGGAGGCGGTTGCGGTTAGTG
GACCGGGACCGGTAGGGGTGCTGTTGCCATCATGGCTGACCCCGACCCCCGGTACCCTCGCTCCTCGATCGAGGACGACTTCAACTATGG
CAGCAGCGTGGCCTCCGCCACCGTGCACATCCGAATGGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCTTAACTAC
AGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCCTCGGATC
TCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGGAAGCTCT
GACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTTTGACTGT
GTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGTACTTCCTCGCGTATTGCTAAAGGAGGAGTTGACCACACCAAAAT
GAGTCTACATGGTGCTAGTGGGGGACATGAGAGATCAAGAGATAGACGAAGGTCAAGTGACAGATCACGAGATTCATCTCATGAAAGAAC
GGAGTCTCAGCTCACTCCTTGTATTAGAAATGTGACTTCTCCAACACGACAGCACCATGTTGAACGAGAAAAAGATCACAGTTCCTCTCG
TCCAAGCAGTCCGCGTCCTCAAAAAGCATCCCCAAATGGTTCCATTAGCAGTGCTGGGAACAGCAGCAGAAACAGTAGTCAGTCAAGTTC
AGATGGTAGCTGTAAGACAGCTGGGGAGATGGTGTTTGTATATGAAAATGCAAAAGAAGGAGCTCGGAATATAAGAACGTCAGAACGAGT
GACACTAATAGTGGATAACACTAGATTTGTTGTAGACCCATCCATTTTTACTGCACAGCCAAATACAATGTTGGGCAGGATGTTTGGATC
TGGCCGAGAACATAACTTTACACGACCCAATGAGAAAGGAGAGTATGAGGTGGCAGAGGGAATTGGTTCCACTGTGTTTCGAGCGATTCT
GGATTACTATAAAACAGGAATAATCCGTTGTCCTGATGGCATATCTATTCCTGAACTGAGAGAAGCATGTGACTATCTTTGTATCTCTTT
TGAATATAGCACTATTAAATGTAGAGATCTCAGTGCCCTAATGCATGAGTTATCAAATGATGGTGCTCGTAGACAATTTGAATTTTATCT
GGAAGAAATGATCCTCCCTCTCATGGTAGCTAGTGCCCAGAGTGGGGAACGGGAATGTCATATAGTGGTGCTTACAGATGATGATGTGGT
TGATTGGGATGAAGAATATCCACCACAGATGGGAGAAGAATATTCACAAATTATTTATAGCACAAAATTATATAGATTTTTCAAGTATAT
TGAAAACAGAGATGTGGCCAAGTCAGTTTTGAAGGAGAGGGGTCTTAAGAAGATTAGATTGGGAATAGAAGGTTATCCTACCTACAAAGA
AAAAGTAAAGAAAAGGCCTGGAGGCCGCCCAGAAGTGATCTACAACTATGTCCAAAGACCCTTTATTCGAATGTCCTGGGAGAAGGAAGA
AGGAAAGAGTCGGCATGTAGACTTTCAGTGTGTAAAGAGTAAATCTATCACCAATCTTGCAGCAGCTGCAGCAGACATTCCCCAGGACCA
GCTGGTAGTCATGCATCCAACTCCACAAGTGGATGAGCTGGATATTCTCCCTATCCATCCCCCTTCTGGCAACAGTGACCTCGATCCTGA
TGCACAGAATCCAATGCTGTGATGCTGATCTTCCTTGAAACCATAGCATGCTACTCTTCACAGTGACGTTGTACTCTCCTCATTCTGCAC
TGCAAGGCCACTCTTCTTCATTGTGAGATGCACATAACAATGTTTAGGATATTGCAGTGTAGGCTTTTTTAAAGACCAAAGGTAGCTGAA
TGGTTTTTTTTTAAATGAGTACAACTCTAGCATTTTGAAGTTCCAGTTGTAAATGTATTTGTTTACCAGTAGGTTTGTGAAATTGGTTCT
TTGTATGGGGGATGGTCCTTTTTCACACAGCTAGGTCTTTTCAGAAGTGGTGGAAATTGGCAGCTGGGGTACTTTCAGTTTGGACTGATA
TTCATCACACCTCAGATAAAATGCAGAGTAATATATAGTTGCACTTTATAAATGGTGGTTAAATGGAAATGTTCAAGCCATTTTATAGTT
GTGATGCACAATATAATTTAAGTGCTTCTGTCAAAGTATTCCTCCAGTACAATTTGTATAGTTTGCTGCCCTTGATGAGCAAAAAGTATT
TATCTTGGGCTTATCTGAATGATCAGGATGAGATTTAATGCCCATATCTTACCAGTTCAGTTATCTCCAGAGCCATTTCACCCTTTAGAG
TGAGTCACATGCAGGGAGTGTGAATGTCAGAGGTGGTTTATTATCCAGTCTGCCTTACCCTTAATCTGTTCACAGATATTTATTTACTAA
TGCTTTTTTTTTCTTAAGAGTTATGGGATAGGAAAATGAAGTGTTTGCTCTTCATTTACTAAATGATTGTAAACTTGAGTTTTTCATCAA

>91294_91294_3_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000358230_BTBD10_chr11_13443386_ENST00000278174_length(amino acids)=596AA_BP=82
MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILN
RHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGTSSRIAKGGVDHTKMSLHGASGGHE
RSRDRRRSSDRSRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTAGEM
VFVYENAKEGARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRC
PDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQM
GEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQC

--------------------------------------------------------------
>91294_91294_4_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000358230_BTBD10_chr11_13443386_ENST00000530907_length(transcript)=2060nt_BP=585nt
CTCGCTCGGTGTTCGCCCGCCGACGCCGCACGGCTTGCTGGGGCTGGGCTCTTCCTCGCGGAAGTGGGGAGGAGGCGGTTGCGGTTAGTG
GACCGGGACCGGTAGGGGTGCTGTTGCCATCATGGCTGACCCCGACCCCCGGTACCCTCGCTCCTCGATCGAGGACGACTTCAACTATGG
CAGCAGCGTGGCCTCCGCCACCGTGCACATCCGAATGGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGCAGGTTCTCTTAACTAC
AGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCCTCGGATC
TCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGGAAGCTCT
GACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTTTGACTGT
GTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGTACTTCCTCGCGTATTGCTAAAGGAGGAGTTGACCACACCAAAAT
GAGTCTACATGGTGCTAGTGGGGGACATGAGAGATCAAGAGATAGACGAAGGTCAAGTGACAGATCACGAGATTCATCTCATGAAAGAAC
GGAGTCTCAGCTCACTCCTTGTATTAGAAATGTGACTTCTCCAACACGACAGCACCATGTTGAACGAGAAAAAGATCACAGTTCCTCTCG
TCCAAGCAGTCCGCGTCCTCAAAAAGCATCCCCAAATGGTTCCATTAGCAGTGCTGGGAACAGCAGCAGAAACAGTAGTCAGTCAAGTTC
AGATGGTAGCTGTAAGACAGCTGGGGAGATGGTGTTTGTATATGAAAATGCAAAAGAAGGAGCTCGGAATATAAGAACGTCAGAACGAGT
GACACTAATAGTGGATAACACTAGATTTGTTGTAGACCCATCCATTTTTACTGCACAGCCAAATACAATGTTGGGCAGGATGTTTGGATC
TGGCCGAGAACATAACTTTACACGACCCAATGAGAAAGGAGAGTATGAGGTGGCAGAGGGAATTGGTTCCACTGTGTTTCGAGCGATTCT
GGATTACTATAAAACAGGAATAATCCGTTGTCCTGATGGCATATCTATTCCTGAACTGAGAGAAGCATGTGACTATCTTTGTATCTCTTT
TGAATATAGCACTATTAAATGTAGAGATCTCAGTGCCCTAATGCATGAGTTATCAAATGATGGTGCTCGTAGACAATTTGAATTTTATCT
GGAAGAAATGATCCTCCCTCTCATGGTAGCTAGTGCCCAGAGTGGGGAACGGGAATGTCATATAGTGGTGCTTACAGATGATGATGTGGT
TGATTGGGATGAAGAATATCCACCACAGATGGGAGAAGAATATTCACAAATTATTTATAGCACAAAATTATATAGATTTTTCAAGTATAT
TGAAAACAGAGATGTGGCCAAGTCAGTTTTGAAGGAGAGGGGTCTTAAGAAGATTAGATTGGGAATAGAAGGTTATCCTACCTACAAAGA
AAAAGTAAAGAAAAGGCCTGGAGGCCGCCCAGAAGTGATCTACAACTATGTCCAAAGACCCTTTATTCGAATGTCCTGGGAGAAGGAAGA
AGGAAAGAGTCGGCATGTAGACTTTCAGTGTGTAAAGAGTAAATCTATCACCAATCTTGCAGCAGCTGCAGCAGACATTCCCCAGGACCA
GCTGGTAGTCATGCATCCAACTCCACAAGTGGATGAGCTGGATATTCTCCCTATCCATCCCCCTTCTGGCAACAGTGACCTCGATCCTGA
TGCACAGAATCCAATGCTGTGATGCTGATCTTCCTTGAAACCATAGCATGCTACTCTTCACAGTGACGTTGTACTCTCCTCATTCTGCAC

>91294_91294_4_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000358230_BTBD10_chr11_13443386_ENST00000530907_length(amino acids)=596AA_BP=82
MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILN
RHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGTSSRIAKGGVDHTKMSLHGASGGHE
RSRDRRRSSDRSRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTAGEM
VFVYENAKEGARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRC
PDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQM
GEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQC

--------------------------------------------------------------
>91294_91294_5_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000398033_BTBD10_chr11_13443386_ENST00000278174_length(transcript)=2668nt_BP=511nt
GCGGTTGCGGTTAGTGGACCGGGACCGGTAGGGGTGCTGTTGCCATCATGGCTGACCCCGACCCCCGGTACCCTCGCTCCTCGATCGAGG
ACGACTTCAACTATGGCAGCAGCGTGGCCTCCGCCACCGTGCACATCCGAATGGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGC
AGGTTCTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGC
TGTTTGCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTA
CGCTGTTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTAT
TTTTTGGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGTACTTCCTCGCGTATTGCTAAAGGAGGAG
TTGACCACACCAAAATGAGTCTACATGGTGCTAGTGGGGGACATGAGAGATCAAGAGATAGACGAAGGTCAAGTGACAGATCACGAGATT
CATCTCATGAAAGAACGGAGTCTCAGCTCACTCCTTGTATTAGAAATGTGACTTCTCCAACACGACAGCACCATGTTGAACGAGAAAAAG
ATCACAGTTCCTCTCGTCCAAGCAGTCCGCGTCCTCAAAAAGCATCCCCAAATGGTTCCATTAGCAGTGCTGGGAACAGCAGCAGAAACA
GTAGTCAGTCAAGTTCAGATGGTAGCTGTAAGACAGCTGGGGAGATGGTGTTTGTATATGAAAATGCAAAAGAAGGAGCTCGGAATATAA
GAACGTCAGAACGAGTGACACTAATAGTGGATAACACTAGATTTGTTGTAGACCCATCCATTTTTACTGCACAGCCAAATACAATGTTGG
GCAGGATGTTTGGATCTGGCCGAGAACATAACTTTACACGACCCAATGAGAAAGGAGAGTATGAGGTGGCAGAGGGAATTGGTTCCACTG
TGTTTCGAGCGATTCTGGATTACTATAAAACAGGAATAATCCGTTGTCCTGATGGCATATCTATTCCTGAACTGAGAGAAGCATGTGACT
ATCTTTGTATCTCTTTTGAATATAGCACTATTAAATGTAGAGATCTCAGTGCCCTAATGCATGAGTTATCAAATGATGGTGCTCGTAGAC
AATTTGAATTTTATCTGGAAGAAATGATCCTCCCTCTCATGGTAGCTAGTGCCCAGAGTGGGGAACGGGAATGTCATATAGTGGTGCTTA
CAGATGATGATGTGGTTGATTGGGATGAAGAATATCCACCACAGATGGGAGAAGAATATTCACAAATTATTTATAGCACAAAATTATATA
GATTTTTCAAGTATATTGAAAACAGAGATGTGGCCAAGTCAGTTTTGAAGGAGAGGGGTCTTAAGAAGATTAGATTGGGAATAGAAGGTT
ATCCTACCTACAAAGAAAAAGTAAAGAAAAGGCCTGGAGGCCGCCCAGAAGTGATCTACAACTATGTCCAAAGACCCTTTATTCGAATGT
CCTGGGAGAAGGAAGAAGGAAAGAGTCGGCATGTAGACTTTCAGTGTGTAAAGAGTAAATCTATCACCAATCTTGCAGCAGCTGCAGCAG
ACATTCCCCAGGACCAGCTGGTAGTCATGCATCCAACTCCACAAGTGGATGAGCTGGATATTCTCCCTATCCATCCCCCTTCTGGCAACA
GTGACCTCGATCCTGATGCACAGAATCCAATGCTGTGATGCTGATCTTCCTTGAAACCATAGCATGCTACTCTTCACAGTGACGTTGTAC
TCTCCTCATTCTGCACTGCAAGGCCACTCTTCTTCATTGTGAGATGCACATAACAATGTTTAGGATATTGCAGTGTAGGCTTTTTTAAAG
ACCAAAGGTAGCTGAATGGTTTTTTTTTAAATGAGTACAACTCTAGCATTTTGAAGTTCCAGTTGTAAATGTATTTGTTTACCAGTAGGT
TTGTGAAATTGGTTCTTTGTATGGGGGATGGTCCTTTTTCACACAGCTAGGTCTTTTCAGAAGTGGTGGAAATTGGCAGCTGGGGTACTT
TCAGTTTGGACTGATATTCATCACACCTCAGATAAAATGCAGAGTAATATATAGTTGCACTTTATAAATGGTGGTTAAATGGAAATGTTC
AAGCCATTTTATAGTTGTGATGCACAATATAATTTAAGTGCTTCTGTCAAAGTATTCCTCCAGTACAATTTGTATAGTTTGCTGCCCTTG
ATGAGCAAAAAGTATTTATCTTGGGCTTATCTGAATGATCAGGATGAGATTTAATGCCCATATCTTACCAGTTCAGTTATCTCCAGAGCC
ATTTCACCCTTTAGAGTGAGTCACATGCAGGGAGTGTGAATGTCAGAGGTGGTTTATTATCCAGTCTGCCTTACCCTTAATCTGTTCACA
GATATTTATTTACTAATGCTTTTTTTTTCTTAAGAGTTATGGGATAGGAAAATGAAGTGTTTGCTCTTCATTTACTAAATGATTGTAAAC

>91294_91294_5_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000398033_BTBD10_chr11_13443386_ENST00000278174_length(amino acids)=596AA_BP=82
MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILN
RHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGTSSRIAKGGVDHTKMSLHGASGGHE
RSRDRRRSSDRSRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTAGEM
VFVYENAKEGARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRC
PDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQM
GEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQC

--------------------------------------------------------------
>91294_91294_6_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000398033_BTBD10_chr11_13443386_ENST00000530907_length(transcript)=1986nt_BP=511nt
GCGGTTGCGGTTAGTGGACCGGGACCGGTAGGGGTGCTGTTGCCATCATGGCTGACCCCGACCCCCGGTACCCTCGCTCCTCGATCGAGG
ACGACTTCAACTATGGCAGCAGCGTGGCCTCCGCCACCGTGCACATCCGAATGGCCTTTCTGAGAAAAGTCTACAGCATTCTTTCTCTGC
AGGTTCTCTTAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGC
TGTTTGCCCTCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTA
CGCTGTTGGAAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTAT
TTTTTGGTTTGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGTACTTCCTCGCGTATTGCTAAAGGAGGAG
TTGACCACACCAAAATGAGTCTACATGGTGCTAGTGGGGGACATGAGAGATCAAGAGATAGACGAAGGTCAAGTGACAGATCACGAGATT
CATCTCATGAAAGAACGGAGTCTCAGCTCACTCCTTGTATTAGAAATGTGACTTCTCCAACACGACAGCACCATGTTGAACGAGAAAAAG
ATCACAGTTCCTCTCGTCCAAGCAGTCCGCGTCCTCAAAAAGCATCCCCAAATGGTTCCATTAGCAGTGCTGGGAACAGCAGCAGAAACA
GTAGTCAGTCAAGTTCAGATGGTAGCTGTAAGACAGCTGGGGAGATGGTGTTTGTATATGAAAATGCAAAAGAAGGAGCTCGGAATATAA
GAACGTCAGAACGAGTGACACTAATAGTGGATAACACTAGATTTGTTGTAGACCCATCCATTTTTACTGCACAGCCAAATACAATGTTGG
GCAGGATGTTTGGATCTGGCCGAGAACATAACTTTACACGACCCAATGAGAAAGGAGAGTATGAGGTGGCAGAGGGAATTGGTTCCACTG
TGTTTCGAGCGATTCTGGATTACTATAAAACAGGAATAATCCGTTGTCCTGATGGCATATCTATTCCTGAACTGAGAGAAGCATGTGACT
ATCTTTGTATCTCTTTTGAATATAGCACTATTAAATGTAGAGATCTCAGTGCCCTAATGCATGAGTTATCAAATGATGGTGCTCGTAGAC
AATTTGAATTTTATCTGGAAGAAATGATCCTCCCTCTCATGGTAGCTAGTGCCCAGAGTGGGGAACGGGAATGTCATATAGTGGTGCTTA
CAGATGATGATGTGGTTGATTGGGATGAAGAATATCCACCACAGATGGGAGAAGAATATTCACAAATTATTTATAGCACAAAATTATATA
GATTTTTCAAGTATATTGAAAACAGAGATGTGGCCAAGTCAGTTTTGAAGGAGAGGGGTCTTAAGAAGATTAGATTGGGAATAGAAGGTT
ATCCTACCTACAAAGAAAAAGTAAAGAAAAGGCCTGGAGGCCGCCCAGAAGTGATCTACAACTATGTCCAAAGACCCTTTATTCGAATGT
CCTGGGAGAAGGAAGAAGGAAAGAGTCGGCATGTAGACTTTCAGTGTGTAAAGAGTAAATCTATCACCAATCTTGCAGCAGCTGCAGCAG
ACATTCCCCAGGACCAGCTGGTAGTCATGCATCCAACTCCACAAGTGGATGAGCTGGATATTCTCCCTATCCATCCCCCTTCTGGCAACA
GTGACCTCGATCCTGATGCACAGAATCCAATGCTGTGATGCTGATCTTCCTTGAAACCATAGCATGCTACTCTTCACAGTGACGTTGTAC
TCTCCTCATTCTGCACTGCAAGGCCACTCTTCTTCATTGTGAGATGCACATAACAATGTTTAGGATATTGCAGTGTAGGCTTTTTTAAAG

>91294_91294_6_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000398033_BTBD10_chr11_13443386_ENST00000530907_length(amino acids)=596AA_BP=82
MADPDPRYPRSSIEDDFNYGSSVASATVHIRMAFLRKVYSILSLQVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILN
RHKYPLNLYLLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGTSSRIAKGGVDHTKMSLHGASGGHE
RSRDRRRSSDRSRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTAGEM
VFVYENAKEGARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRC
PDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQM
GEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQC

--------------------------------------------------------------
>91294_91294_7_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000542724_BTBD10_chr11_13443386_ENST00000278174_length(transcript)=2659nt_BP=502nt
GGGCTCTTCCTCGCGGAAGTGGGGAGGAGGCGGTTGCGGTTAGTGGACCGGGACCGGTAGGGGTGCTGTTGCCATCATGGCTGACCCCGA
CCCCCGGTACCCTCGCTCCTCGATCGAGGACGACTTCAACTATGGCAGCAGCGTGGCCTCCGCCACCGTGCACATCCGAATGGGTTCTCT
TAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCC
TCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGG
AAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTT
TGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGTACTTCCTCGCGTATTGCTAAAGGAGGAGTTGACCACA
CCAAAATGAGTCTACATGGTGCTAGTGGGGGACATGAGAGATCAAGAGATAGACGAAGGTCAAGTGACAGATCACGAGATTCATCTCATG
AAAGAACGGAGTCTCAGCTCACTCCTTGTATTAGAAATGTGACTTCTCCAACACGACAGCACCATGTTGAACGAGAAAAAGATCACAGTT
CCTCTCGTCCAAGCAGTCCGCGTCCTCAAAAAGCATCCCCAAATGGTTCCATTAGCAGTGCTGGGAACAGCAGCAGAAACAGTAGTCAGT
CAAGTTCAGATGGTAGCTGTAAGACAGCTGGGGAGATGGTGTTTGTATATGAAAATGCAAAAGAAGGAGCTCGGAATATAAGAACGTCAG
AACGAGTGACACTAATAGTGGATAACACTAGATTTGTTGTAGACCCATCCATTTTTACTGCACAGCCAAATACAATGTTGGGCAGGATGT
TTGGATCTGGCCGAGAACATAACTTTACACGACCCAATGAGAAAGGAGAGTATGAGGTGGCAGAGGGAATTGGTTCCACTGTGTTTCGAG
CGATTCTGGATTACTATAAAACAGGAATAATCCGTTGTCCTGATGGCATATCTATTCCTGAACTGAGAGAAGCATGTGACTATCTTTGTA
TCTCTTTTGAATATAGCACTATTAAATGTAGAGATCTCAGTGCCCTAATGCATGAGTTATCAAATGATGGTGCTCGTAGACAATTTGAAT
TTTATCTGGAAGAAATGATCCTCCCTCTCATGGTAGCTAGTGCCCAGAGTGGGGAACGGGAATGTCATATAGTGGTGCTTACAGATGATG
ATGTGGTTGATTGGGATGAAGAATATCCACCACAGATGGGAGAAGAATATTCACAAATTATTTATAGCACAAAATTATATAGATTTTTCA
AGTATATTGAAAACAGAGATGTGGCCAAGTCAGTTTTGAAGGAGAGGGGTCTTAAGAAGATTAGATTGGGAATAGAAGGTTATCCTACCT
ACAAAGAAAAAGTAAAGAAAAGGCCTGGAGGCCGCCCAGAAGTGATCTACAACTATGTCCAAAGACCCTTTATTCGAATGTCCTGGGAGA
AGGAAGAAGGAAAGAGTCGGCATGTAGACTTTCAGTGTGTAAAGAGTAAATCTATCACCAATCTTGCAGCAGCTGCAGCAGACATTCCCC
AGGACCAGCTGGTAGTCATGCATCCAACTCCACAAGTGGATGAGCTGGATATTCTCCCTATCCATCCCCCTTCTGGCAACAGTGACCTCG
ATCCTGATGCACAGAATCCAATGCTGTGATGCTGATCTTCCTTGAAACCATAGCATGCTACTCTTCACAGTGACGTTGTACTCTCCTCAT
TCTGCACTGCAAGGCCACTCTTCTTCATTGTGAGATGCACATAACAATGTTTAGGATATTGCAGTGTAGGCTTTTTTAAAGACCAAAGGT
AGCTGAATGGTTTTTTTTTAAATGAGTACAACTCTAGCATTTTGAAGTTCCAGTTGTAAATGTATTTGTTTACCAGTAGGTTTGTGAAAT
TGGTTCTTTGTATGGGGGATGGTCCTTTTTCACACAGCTAGGTCTTTTCAGAAGTGGTGGAAATTGGCAGCTGGGGTACTTTCAGTTTGG
ACTGATATTCATCACACCTCAGATAAAATGCAGAGTAATATATAGTTGCACTTTATAAATGGTGGTTAAATGGAAATGTTCAAGCCATTT
TATAGTTGTGATGCACAATATAATTTAAGTGCTTCTGTCAAAGTATTCCTCCAGTACAATTTGTATAGTTTGCTGCCCTTGATGAGCAAA
AAGTATTTATCTTGGGCTTATCTGAATGATCAGGATGAGATTTAATGCCCATATCTTACCAGTTCAGTTATCTCCAGAGCCATTTCACCC
TTTAGAGTGAGTCACATGCAGGGAGTGTGAATGTCAGAGGTGGTTTATTATCCAGTCTGCCTTACCCTTAATCTGTTCACAGATATTTAT
TTACTAATGCTTTTTTTTTCTTAAGAGTTATGGGATAGGAAAATGAAGTGTTTGCTCTTCATTTACTAAATGATTGTAAACTTGAGTTTT

>91294_91294_7_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000542724_BTBD10_chr11_13443386_ENST00000278174_length(amino acids)=587AA_BP=73
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLY
LLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGTSSRIAKGGVDHTKMSLHGASGGHERSRDRRRSS
DRSRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTAGEMVFVYENAKE
GARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPEL
REACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIY
STKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNL

--------------------------------------------------------------
>91294_91294_8_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000542724_BTBD10_chr11_13443386_ENST00000530907_length(transcript)=1977nt_BP=502nt
GGGCTCTTCCTCGCGGAAGTGGGGAGGAGGCGGTTGCGGTTAGTGGACCGGGACCGGTAGGGGTGCTGTTGCCATCATGGCTGACCCCGA
CCCCCGGTACCCTCGCTCCTCGATCGAGGACGACTTCAACTATGGCAGCAGCGTGGCCTCCGCCACCGTGCACATCCGAATGGGTTCTCT
TAACTACAGTGACTTCAACAGTTTTTTTATACTTTGAGTCTGTACGGACATTTGTACATGAGAGTCCTGCCTTAATTTTGCTGTTTGCCC
TCGGATCTCTGGGTTTGATTTTTGCGTTGATTTTAAACAGACATAAGTATCCCCTTAACCTGTACCTACTTTTTGGATTTACGCTGTTGG
AAGCTCTGACTGTGGCAGTTGTTGTTACTTTCTATGATGTATATATTATTCTGCAAGCTTTCATACTGACTACTACAGTATTTTTTGGTT
TGACTGTGTATACTCTACAATCTAAGAAGGATTTCAGCAAATTTGGAGCAGGTACTTCCTCGCGTATTGCTAAAGGAGGAGTTGACCACA
CCAAAATGAGTCTACATGGTGCTAGTGGGGGACATGAGAGATCAAGAGATAGACGAAGGTCAAGTGACAGATCACGAGATTCATCTCATG
AAAGAACGGAGTCTCAGCTCACTCCTTGTATTAGAAATGTGACTTCTCCAACACGACAGCACCATGTTGAACGAGAAAAAGATCACAGTT
CCTCTCGTCCAAGCAGTCCGCGTCCTCAAAAAGCATCCCCAAATGGTTCCATTAGCAGTGCTGGGAACAGCAGCAGAAACAGTAGTCAGT
CAAGTTCAGATGGTAGCTGTAAGACAGCTGGGGAGATGGTGTTTGTATATGAAAATGCAAAAGAAGGAGCTCGGAATATAAGAACGTCAG
AACGAGTGACACTAATAGTGGATAACACTAGATTTGTTGTAGACCCATCCATTTTTACTGCACAGCCAAATACAATGTTGGGCAGGATGT
TTGGATCTGGCCGAGAACATAACTTTACACGACCCAATGAGAAAGGAGAGTATGAGGTGGCAGAGGGAATTGGTTCCACTGTGTTTCGAG
CGATTCTGGATTACTATAAAACAGGAATAATCCGTTGTCCTGATGGCATATCTATTCCTGAACTGAGAGAAGCATGTGACTATCTTTGTA
TCTCTTTTGAATATAGCACTATTAAATGTAGAGATCTCAGTGCCCTAATGCATGAGTTATCAAATGATGGTGCTCGTAGACAATTTGAAT
TTTATCTGGAAGAAATGATCCTCCCTCTCATGGTAGCTAGTGCCCAGAGTGGGGAACGGGAATGTCATATAGTGGTGCTTACAGATGATG
ATGTGGTTGATTGGGATGAAGAATATCCACCACAGATGGGAGAAGAATATTCACAAATTATTTATAGCACAAAATTATATAGATTTTTCA
AGTATATTGAAAACAGAGATGTGGCCAAGTCAGTTTTGAAGGAGAGGGGTCTTAAGAAGATTAGATTGGGAATAGAAGGTTATCCTACCT
ACAAAGAAAAAGTAAAGAAAAGGCCTGGAGGCCGCCCAGAAGTGATCTACAACTATGTCCAAAGACCCTTTATTCGAATGTCCTGGGAGA
AGGAAGAAGGAAAGAGTCGGCATGTAGACTTTCAGTGTGTAAAGAGTAAATCTATCACCAATCTTGCAGCAGCTGCAGCAGACATTCCCC
AGGACCAGCTGGTAGTCATGCATCCAACTCCACAAGTGGATGAGCTGGATATTCTCCCTATCCATCCCCCTTCTGGCAACAGTGACCTCG
ATCCTGATGCACAGAATCCAATGCTGTGATGCTGATCTTCCTTGAAACCATAGCATGCTACTCTTCACAGTGACGTTGTACTCTCCTCAT

>91294_91294_8_TMBIM4-BTBD10_TMBIM4_chr12_66539621_ENST00000542724_BTBD10_chr11_13443386_ENST00000530907_length(amino acids)=587AA_BP=73
MLPSWLTPTPGTLAPRSRTTSTMAAAWPPPPCTSEWVLLTTVTSTVFLYFESVRTFVHESPALILLFALGSLGLIFALILNRHKYPLNLY
LLFGFTLLEALTVAVVVTFYDVYIILQAFILTTTVFFGLTVYTLQSKKDFSKFGAGTSSRIAKGGVDHTKMSLHGASGGHERSRDRRRSS
DRSRDSSHERTESQLTPCIRNVTSPTRQHHVEREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTAGEMVFVYENAKE
GARNIRTSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPEL
REACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIY
STKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMBIM4-BTBD10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneBTBD10chr12:66539621chr11:13443386ENST0000027817419146_47533.666666666666664476.0AKT family members


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMBIM4-BTBD10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMBIM4-BTBD10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource