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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMBIM6-ARPC3 (FusionGDB2 ID:91308)

Fusion Gene Summary for TMBIM6-ARPC3

check button Fusion gene summary
Fusion gene informationFusion gene name: TMBIM6-ARPC3
Fusion gene ID: 91308
HgeneTgene
Gene symbol

TMBIM6

ARPC3

Gene ID

7009

10094

Gene nametransmembrane BAX inhibitor motif containing 6actin related protein 2/3 complex subunit 3
SynonymsBAXI1|BI-1|TEGTARC21|p21-Arc
Cytomap

12q13.12

12q24.11

Type of geneprotein-codingprotein-coding
Descriptionbax inhibitor 1testis enhanced gene transcripttestis-enhanced gene transcript proteintransmembrane BAX inhibitor motif-containing protein 6actin-related protein 2/3 complex subunit 3ARP2/3 protein complex subunit p21actin related protein 2/3 complex, subunit 3, 21kDaarp2/3 complex 21 kDa subunit
Modification date2020031320200313
UniProtAcc.

O15145

Ensembl transtripts involved in fusion geneENST00000267115, ENST00000395006, 
ENST00000423828, ENST00000547798, 
ENST00000549385, ENST00000552699, 
ENST00000548589, 		ENST00000471641, 
ENST00000228825, 
Fusion gene scores* DoF score18 X 20 X 7=25206 X 4 X 4=96
# samples 217
** MAII scorelog2(21/2520*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMBIM6 [Title/Abstract] AND ARPC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMBIM6(50149538)-ARPC3(110878193), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMBIM6

GO:0010523

negative regulation of calcium ion transport into cytosol

26582200

HgeneTMBIM6

GO:0032091

negative regulation of protein binding

19328063

HgeneTMBIM6

GO:0033119

negative regulation of RNA splicing

19328063

HgeneTMBIM6

GO:0034620

cellular response to unfolded protein

19328063

HgeneTMBIM6

GO:0060702

negative regulation of endoribonuclease activity

19328063

HgeneTMBIM6

GO:1902065

response to L-glutamate

21075086

HgeneTMBIM6

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

21075086

HgeneTMBIM6

GO:1903298

negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway

21075086

HgeneTMBIM6

GO:2001234

negative regulation of apoptotic signaling pathway

21075086

TgeneARPC3

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539


check buttonFusion gene breakpoints across TMBIM6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARPC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer61NTMBIM6chr12

50149538

+ARPC3chr12

110878193

-


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Fusion Gene ORF analysis for TMBIM6-ARPC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000267115ENST00000471641TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
5CDS-intronENST00000395006ENST00000471641TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
5CDS-intronENST00000423828ENST00000471641TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
5CDS-intronENST00000547798ENST00000471641TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
5CDS-intronENST00000549385ENST00000471641TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
5CDS-intronENST00000552699ENST00000471641TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
In-frameENST00000267115ENST00000228825TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
In-frameENST00000395006ENST00000228825TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
In-frameENST00000423828ENST00000228825TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
In-frameENST00000547798ENST00000228825TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
In-frameENST00000549385ENST00000228825TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
In-frameENST00000552699ENST00000228825TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
intron-3CDSENST00000548589ENST00000228825TMBIM6chr12

50149538

+ARPC3chr12

110878193

-
intron-intronENST00000548589ENST00000471641TMBIM6chr12

50149538

+ARPC3chr12

110878193

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000552699TMBIM6chr1250149538+ENST00000228825ARPC3chr12110878193-14566952351125296
ENST00000267115TMBIM6chr1250149538+ENST00000228825ARPC3chr12110878193-113237134801255
ENST00000549385TMBIM6chr1250149538+ENST00000228825ARPC3chr12110878193-1274513227943238
ENST00000423828TMBIM6chr1250149538+ENST00000228825ARPC3chr12110878193-15497883281218296
ENST00000395006TMBIM6chr1250149538+ENST00000228825ARPC3chr12110878193-10853242754250
ENST00000547798TMBIM6chr1250149538+ENST00000228825ARPC3chr12110878193-100023931669212

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000552699ENST00000228825TMBIM6chr1250149538+ARPC3chr12110878193-0.0014841490.9985159
ENST00000267115ENST00000228825TMBIM6chr1250149538+ARPC3chr12110878193-0.0029305760.9970694
ENST00000549385ENST00000228825TMBIM6chr1250149538+ARPC3chr12110878193-0.004158840.9958411
ENST00000423828ENST00000228825TMBIM6chr1250149538+ARPC3chr12110878193-0.001599970.99840003
ENST00000395006ENST00000228825TMBIM6chr1250149538+ARPC3chr12110878193-0.0031381890.9968618
ENST00000547798ENST00000228825TMBIM6chr1250149538+ARPC3chr12110878193-0.003036990.99696296

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Fusion Genomic Features for TMBIM6-ARPC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMBIM6-ARPC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:50149538/chr12:110878193)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARPC3

O15145

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+4101_2995238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+41051_5295238.0Topological domainLumenal
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+41074_8695238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+391_2995238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+3951_5295238.0Topological domainLumenal
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+3974_8695238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+5111_2995238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+51151_5295238.0Topological domainLumenal
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+51174_8695238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+41030_5095238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+41053_7395238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+3930_5095238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+3953_7395238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+51130_5095238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+51153_7395238.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+410207_22795238.0IntramembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+39207_22795238.0IntramembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+511207_22795238.0IntramembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+410108_11295238.0Topological domainLumenal
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+410134_13995238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+410161_16695238.0Topological domainLumenal
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+410188_20695238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+410228_23795238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+39108_11295238.0Topological domainLumenal
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+39134_13995238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+39161_16695238.0Topological domainLumenal
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+39188_20695238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+39228_23795238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+511108_11295238.0Topological domainLumenal
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+511134_13995238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+511161_16695238.0Topological domainLumenal
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+511188_20695238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+511228_23795238.0Topological domainCytoplasmic
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+410113_13395238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+410140_16095238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+410167_18795238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000267115+41087_10795238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+39113_13395238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+39140_16095238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+39167_18795238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000395006+3987_10795238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+511113_13395238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+511140_16095238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+511167_18795238.0TransmembraneHelical
HgeneTMBIM6chr12:50149538chr12:110878193ENST00000549385+51187_10795238.0TransmembraneHelical


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Fusion Gene Sequence for TMBIM6-ARPC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91308_91308_1_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000267115_ARPC3_chr12_110878193_ENST00000228825_length(transcript)=1132nt_BP=371nt
AGAGCACATCCGGTGTTAGAAGCGCTGGTAGGCCTTGGAGAGGCGGGTTAGGAAGAGTGGAGACTGCTGCACGGACTCTGGAACCATGAA
CATATTTGATCGAAAGATCAACTTTGATGCGCTTTTAAAATTTTCTCATATAACCCCGTCAACGCAGCAGCACCTGAAGAAGGTCTATGC
AAGTTTTGCCCTTTGTATGTTTGTGGCGGCTGCAGGGGCCTATGTCCATATGGTCACTCATTTCATTCAGGCTGGCCTGCTGTCTGCCTT
GGGCTCCCTGATATTGATGATTTGGCTGATGGCAACACCTCATAGCCATGAAACTGAACAGAAAAGACTGGGACTTCTTGCTGGATTTGC
ATTCCTTACAGCAAAAGATACAGATATTGTGGATGAAGCCATCTATTACTTCAAGGCCAATGTCTTCTTCAAAAACTATGAAATTAAGAA
TGAAGCTGATAGGACCTTGATATATATAACTCTCTACATTTCTGAATGTCTGAAGAAACTGCAAAAGTGCAATTCCAAAAGCCAAGGTGA
GAAAGAAATGTATACGCTGGGAATCACTAATTTTCCCATTCCTGGAGAGCCTGGTTTTCCACTTAACGCAATTTATGCCAAACCTGCAAA
CAAACAGGAAGATGAAGTGATGAGAGCCTATTTACAACAGCTAAGGCAAGAGACTGGACTGAGACTTTGTGAGAAAGTTTTCGACCCTCA
GAATGATAAACCCAGCAAGTGGTGGACTTGCTTTGTGAAGAGACAGTTCATGAACAAGAGTCTTTCAGGACCTGGACAGTGAAGGGAGCC
CGGGCAGCCACCGTCTCCAGAGCCCTGGGCAGCATTTTCCAGCAAGATGTACACAATCTTTTGCCTTTATTTCGTAAAGTTTTATACAGA
AGAGAGAAGAGCATGTCTTTACTTGAAAAACTCTTGATCAAGAATTTGGGTGGGAGAAAAGAAAGTGGGTTATCAAGGGTGATTTGAAAT
TTTCTGCAGCATTAAAGCTGGCGCTTAATAAGAATAAGTAATAATAAAGAAATTTCTAACATTCCATGTCAGAAAAACTTTATTGCCAGT

>91308_91308_1_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000267115_ARPC3_chr12_110878193_ENST00000228825_length(amino acids)=255AA_BP=112
MERRVRKSGDCCTDSGTMNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMA
TPHSHETEQKRLGLLAGFAFLTAKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNF

--------------------------------------------------------------
>91308_91308_2_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000395006_ARPC3_chr12_110878193_ENST00000228825_length(transcript)=1085nt_BP=324nt
TTCTGCAGAGTGGAGACTGCTGCACGGACTCTGGAACCATGAACATATTTGATCGAAAGATCAACTTTGATGCGCTTTTAAAATTTTCTC
ATATAACCCCGTCAACGCAGCAGCACCTGAAGAAGGTCTATGCAAGTTTTGCCCTTTGTATGTTTGTGGCGGCTGCAGGGGCCTATGTCC
ATATGGTCACTCATTTCATTCAGGCTGGCCTGCTGTCTGCCTTGGGCTCCCTGATATTGATGATTTGGCTGATGGCAACACCTCATAGCC
ATGAAACTGAACAGAAAAGACTGGGACTTCTTGCTGGATTTGCATTCCTTACAGCAAAAGATACAGATATTGTGGATGAAGCCATCTATT
ACTTCAAGGCCAATGTCTTCTTCAAAAACTATGAAATTAAGAATGAAGCTGATAGGACCTTGATATATATAACTCTCTACATTTCTGAAT
GTCTGAAGAAACTGCAAAAGTGCAATTCCAAAAGCCAAGGTGAGAAAGAAATGTATACGCTGGGAATCACTAATTTTCCCATTCCTGGAG
AGCCTGGTTTTCCACTTAACGCAATTTATGCCAAACCTGCAAACAAACAGGAAGATGAAGTGATGAGAGCCTATTTACAACAGCTAAGGC
AAGAGACTGGACTGAGACTTTGTGAGAAAGTTTTCGACCCTCAGAATGATAAACCCAGCAAGTGGTGGACTTGCTTTGTGAAGAGACAGT
TCATGAACAAGAGTCTTTCAGGACCTGGACAGTGAAGGGAGCCCGGGCAGCCACCGTCTCCAGAGCCCTGGGCAGCATTTTCCAGCAAGA
TGTACACAATCTTTTGCCTTTATTTCGTAAAGTTTTATACAGAAGAGAGAAGAGCATGTCTTTACTTGAAAAACTCTTGATCAAGAATTT
GGGTGGGAGAAAAGAAAGTGGGTTATCAAGGGTGATTTGAAATTTTCTGCAGCATTAAAGCTGGCGCTTAATAAGAATAAGTAATAATAA
AGAAATTTCTAACATTCCATGTCAGAAAAACTTTATTGCCAGTCTTTGACATTCACTTACAATTTGTTTTGAGATAAAATTCACATTCCA

>91308_91308_2_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000395006_ARPC3_chr12_110878193_ENST00000228825_length(amino acids)=250AA_BP=107
LQSGDCCTDSGTMNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSH
ETEQKRLGLLAGFAFLTAKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGE

--------------------------------------------------------------
>91308_91308_3_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000423828_ARPC3_chr12_110878193_ENST00000228825_length(transcript)=1549nt_BP=788nt
ACAGTGCTGAAGCGGGGGTGGGGCGGAGGCGAGTCTGCGGGGGTTTTGGGGGGTGTCGAGGCCTCTATTCTGCCCCAGAGCGCTGGCGAA
GGCCCCTTCTCAGCCCGCCTTTTCCTTTCTCCCGCTCCTTCTCCTCTACTAAGTGTAGACGCAGGGCCCCTTGGCCTAGCTTCGATCGTT
CGAATTCAGAGCACGTCCTTCCGAGGTGAAGGAACGCGAAACTCCACCCATCCGATTGCTGTTCGGCTGCGGGCGGGTCCTTTGGTCGGG
CTGACCCTGGGTGAGCGGCCCGGAGCCAAGACTCGAGGTAGGGCCTGGCGGGCGGGTGATGTCACACTCCTCTGTGACACGCGAGGCTCC
TCAGTTACTTAGCCAACGGCAGAGGCGGGAAGTGAGAGGAGTCTGGGGCTGGGGCTGCCTTCCAGGCCCACGGGGCGGCCCCGCTCTTTT
CGGATTGGTTACCTTTGGGCAGAGTGGAGACTGCTGCACGGACTCTGGAACCATGAACATATTTGATCGAAAGATCAACTTTGATGCGCT
TTTAAAATTTTCTCATATAACCCCGTCAACGCAGCAGCACCTGAAGAAGGTCTATGCAAGTTTTGCCCTTTGTATGTTTGTGGCGGCTGC
AGGGGCCTATGTCCATATGGTCACTCATTTCATTCAGGCTGGCCTGCTGTCTGCCTTGGGCTCCCTGATATTGATGATTTGGCTGATGGC
AACACCTCATAGCCATGAAACTGAACAGAAAAGACTGGGACTTCTTGCTGGATTTGCATTCCTTACAGCAAAAGATACAGATATTGTGGA
TGAAGCCATCTATTACTTCAAGGCCAATGTCTTCTTCAAAAACTATGAAATTAAGAATGAAGCTGATAGGACCTTGATATATATAACTCT
CTACATTTCTGAATGTCTGAAGAAACTGCAAAAGTGCAATTCCAAAAGCCAAGGTGAGAAAGAAATGTATACGCTGGGAATCACTAATTT
TCCCATTCCTGGAGAGCCTGGTTTTCCACTTAACGCAATTTATGCCAAACCTGCAAACAAACAGGAAGATGAAGTGATGAGAGCCTATTT
ACAACAGCTAAGGCAAGAGACTGGACTGAGACTTTGTGAGAAAGTTTTCGACCCTCAGAATGATAAACCCAGCAAGTGGTGGACTTGCTT
TGTGAAGAGACAGTTCATGAACAAGAGTCTTTCAGGACCTGGACAGTGAAGGGAGCCCGGGCAGCCACCGTCTCCAGAGCCCTGGGCAGC
ATTTTCCAGCAAGATGTACACAATCTTTTGCCTTTATTTCGTAAAGTTTTATACAGAAGAGAGAAGAGCATGTCTTTACTTGAAAAACTC
TTGATCAAGAATTTGGGTGGGAGAAAAGAAAGTGGGTTATCAAGGGTGATTTGAAATTTTCTGCAGCATTAAAGCTGGCGCTTAATAAGA
ATAAGTAATAATAAAGAAATTTCTAACATTCCATGTCAGAAAAACTTTATTGCCAGTCTTTGACATTCACTTACAATTTGTTTTGAGATA

>91308_91308_3_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000423828_ARPC3_chr12_110878193_ENST00000228825_length(amino acids)=296AA_BP=153
MSHSSVTREAPQLLSQRQRREVRGVWGWGCLPGPRGGPALFGLVTFGQSGDCCTDSGTMNIFDRKINFDALLKFSHITPSTQQHLKKVYA
SFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTAKDTDIVDEAIYYFKANVFFKNYEIKN
EADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQ

--------------------------------------------------------------
>91308_91308_4_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000547798_ARPC3_chr12_110878193_ENST00000228825_length(transcript)=1000nt_BP=239nt
TTTTCTTAGAACCCCGTCAACGCAGCAGCACCTGAAGAAGGTCTATGCAAGTTTTGCCCTTTGTATGTTTGTGGCGGCTGCAGGGGCCTA
TGTCCATATGGTCACTCATTTCATTCAGGCTGGCCTGCTGTCTGCCTTGGGCTCCCTGATATTGATGATTTGGCTGATGGCAACACCTCA
TAGCCATGAAACTGAACAGAAAAGACTGGGACTTCTTGCTGGATTTGCATTCCTTACAGCAAAAGATACAGATATTGTGGATGAAGCCAT
CTATTACTTCAAGGCCAATGTCTTCTTCAAAAACTATGAAATTAAGAATGAAGCTGATAGGACCTTGATATATATAACTCTCTACATTTC
TGAATGTCTGAAGAAACTGCAAAAGTGCAATTCCAAAAGCCAAGGTGAGAAAGAAATGTATACGCTGGGAATCACTAATTTTCCCATTCC
TGGAGAGCCTGGTTTTCCACTTAACGCAATTTATGCCAAACCTGCAAACAAACAGGAAGATGAAGTGATGAGAGCCTATTTACAACAGCT
AAGGCAAGAGACTGGACTGAGACTTTGTGAGAAAGTTTTCGACCCTCAGAATGATAAACCCAGCAAGTGGTGGACTTGCTTTGTGAAGAG
ACAGTTCATGAACAAGAGTCTTTCAGGACCTGGACAGTGAAGGGAGCCCGGGCAGCCACCGTCTCCAGAGCCCTGGGCAGCATTTTCCAG
CAAGATGTACACAATCTTTTGCCTTTATTTCGTAAAGTTTTATACAGAAGAGAGAAGAGCATGTCTTTACTTGAAAAACTCTTGATCAAG
AATTTGGGTGGGAGAAAAGAAAGTGGGTTATCAAGGGTGATTTGAAATTTTCTGCAGCATTAAAGCTGGCGCTTAATAAGAATAAGTAAT
AATAAAGAAATTTCTAACATTCCATGTCAGAAAAACTTTATTGCCAGTCTTTGACATTCACTTACAATTTGTTTTGAGATAAAATTCACA

>91308_91308_4_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000547798_ARPC3_chr12_110878193_ENST00000228825_length(amino acids)=212AA_BP=69
MKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTAKDTDIVDEAIYYFKANVFFK
NYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCE

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>91308_91308_5_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000549385_ARPC3_chr12_110878193_ENST00000228825_length(transcript)=1274nt_BP=513nt
AGAAGCGCTGGTAGGCCTTGGAGAGGCGGGTTAGGAAGACGCAGGGCCCCTTGGCCTAGCTTCGATCGTTCGAATTCAGAGCACGTCCTT
CCGAGGTGAAGGAACGCGAAACTCCACCCATCCGATTGCTGTTCGGCTGCGGGCGGGTCCTTTGGTCGGGCTGACCCTGGGTGAGCGGCC
CGGAGCCAAGACTCGAGAGTGGAGACTGCTGCACGGACTCTGGAACCATGAACATATTTGATCGAAAGATCAACTTTGATGCGCTTTTAA
AATTTTCTCATATAACCCCGTCAACGCAGCAGCACCTGAAGAAGGTCTATGCAAGTTTTGCCCTTTGTATGTTTGTGGCGGCTGCAGGGG
CCTATGTCCATATGGTCACTCATTTCATTCAGGCTGGCCTGCTGTCTGCCTTGGGCTCCCTGATATTGATGATTTGGCTGATGGCAACAC
CTCATAGCCATGAAACTGAACAGAAAAGACTGGGACTTCTTGCTGGATTTGCATTCCTTACAGCAAAAGATACAGATATTGTGGATGAAG
CCATCTATTACTTCAAGGCCAATGTCTTCTTCAAAAACTATGAAATTAAGAATGAAGCTGATAGGACCTTGATATATATAACTCTCTACA
TTTCTGAATGTCTGAAGAAACTGCAAAAGTGCAATTCCAAAAGCCAAGGTGAGAAAGAAATGTATACGCTGGGAATCACTAATTTTCCCA
TTCCTGGAGAGCCTGGTTTTCCACTTAACGCAATTTATGCCAAACCTGCAAACAAACAGGAAGATGAAGTGATGAGAGCCTATTTACAAC
AGCTAAGGCAAGAGACTGGACTGAGACTTTGTGAGAAAGTTTTCGACCCTCAGAATGATAAACCCAGCAAGTGGTGGACTTGCTTTGTGA
AGAGACAGTTCATGAACAAGAGTCTTTCAGGACCTGGACAGTGAAGGGAGCCCGGGCAGCCACCGTCTCCAGAGCCCTGGGCAGCATTTT
CCAGCAAGATGTACACAATCTTTTGCCTTTATTTCGTAAAGTTTTATACAGAAGAGAGAAGAGCATGTCTTTACTTGAAAAACTCTTGAT
CAAGAATTTGGGTGGGAGAAAAGAAAGTGGGTTATCAAGGGTGATTTGAAATTTTCTGCAGCATTAAAGCTGGCGCTTAATAAGAATAAG
TAATAATAAAGAAATTTCTAACATTCCATGTCAGAAAAACTTTATTGCCAGTCTTTGACATTCACTTACAATTTGTTTTGAGATAAAATT

>91308_91308_5_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000549385_ARPC3_chr12_110878193_ENST00000228825_length(amino acids)=238AA_BP=95
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAG
FAFLTAKDTDIVDEAIYYFKANVFFKNYEIKNEADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKP

--------------------------------------------------------------
>91308_91308_6_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000552699_ARPC3_chr12_110878193_ENST00000228825_length(transcript)=1456nt_BP=695nt
AGAGCACATCCGGTGTTAGAAGCGCTGGTAGGCCTTGGAGAGGCGGGTTAGGAAGACGCAGGGCCCCTTGGCCTAGCTTCGATCGTTCGA
ATTCAGAGCACGTCCTTCCGAGGTGAAGGAACGCGAAACTCCACCCATCCGATTGCTGTTCGGCTGCGGGCGGGTCCTTTGGTCGGGCTG
ACCCTGGGTGAGCGGCCCGGAGCCAAGACTCGAGGTAGGGCCTGGCGGGCGGGTGATGTCACACTCCTCTGTGACACGCGAGGCTCCTCA
GTTACTTAGCCAACGGCAGAGGCGGGAAGTGAGAGGAGTCTGGGGCTGGGGCTGCCTTCCAGGCCCACGGGGCGGCCCCGCTCTTTTCGG
ATTGGTTACCTTTGGGCAGAGTGGAGACTGCTGCACGGACTCTGGAACCATGAACATATTTGATCGAAAGATCAACTTTGATGCGCTTTT
AAAATTTTCTCATATAACCCCGTCAACGCAGCAGCACCTGAAGAAGGTCTATGCAAGTTTTGCCCTTTGTATGTTTGTGGCGGCTGCAGG
GGCCTATGTCCATATGGTCACTCATTTCATTCAGGCTGGCCTGCTGTCTGCCTTGGGCTCCCTGATATTGATGATTTGGCTGATGGCAAC
ACCTCATAGCCATGAAACTGAACAGAAAAGACTGGGACTTCTTGCTGGATTTGCATTCCTTACAGCAAAAGATACAGATATTGTGGATGA
AGCCATCTATTACTTCAAGGCCAATGTCTTCTTCAAAAACTATGAAATTAAGAATGAAGCTGATAGGACCTTGATATATATAACTCTCTA
CATTTCTGAATGTCTGAAGAAACTGCAAAAGTGCAATTCCAAAAGCCAAGGTGAGAAAGAAATGTATACGCTGGGAATCACTAATTTTCC
CATTCCTGGAGAGCCTGGTTTTCCACTTAACGCAATTTATGCCAAACCTGCAAACAAACAGGAAGATGAAGTGATGAGAGCCTATTTACA
ACAGCTAAGGCAAGAGACTGGACTGAGACTTTGTGAGAAAGTTTTCGACCCTCAGAATGATAAACCCAGCAAGTGGTGGACTTGCTTTGT
GAAGAGACAGTTCATGAACAAGAGTCTTTCAGGACCTGGACAGTGAAGGGAGCCCGGGCAGCCACCGTCTCCAGAGCCCTGGGCAGCATT
TTCCAGCAAGATGTACACAATCTTTTGCCTTTATTTCGTAAAGTTTTATACAGAAGAGAGAAGAGCATGTCTTTACTTGAAAAACTCTTG
ATCAAGAATTTGGGTGGGAGAAAAGAAAGTGGGTTATCAAGGGTGATTTGAAATTTTCTGCAGCATTAAAGCTGGCGCTTAATAAGAATA
AGTAATAATAAAGAAATTTCTAACATTCCATGTCAGAAAAACTTTATTGCCAGTCTTTGACATTCACTTACAATTTGTTTTGAGATAAAA

>91308_91308_6_TMBIM6-ARPC3_TMBIM6_chr12_50149538_ENST00000552699_ARPC3_chr12_110878193_ENST00000228825_length(amino acids)=296AA_BP=153
MSHSSVTREAPQLLSQRQRREVRGVWGWGCLPGPRGGPALFGLVTFGQSGDCCTDSGTMNIFDRKINFDALLKFSHITPSTQQHLKKVYA
SFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTAKDTDIVDEAIYYFKANVFFKNYEIKN
EADRTLIYITLYISECLKKLQKCNSKSQGEKEMYTLGITNFPIPGEPGFPLNAIYAKPANKQEDEVMRAYLQQLRQETGLRLCEKVFDPQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMBIM6-ARPC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMBIM6-ARPC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMBIM6-ARPC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource