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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMC5-SYT17 (FusionGDB2 ID:91352)

Fusion Gene Summary for TMC5-SYT17

check button Fusion gene summary
Fusion gene informationFusion gene name: TMC5-SYT17
Fusion gene ID: 91352
HgeneTgene
Gene symbol

TMC5

SYT17

Gene ID

79838

51760

Gene nametransmembrane channel like 5synaptotagmin 17
Synonyms-Syt-17|sytXVII
Cytomap

16p12.3

16p12.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane channel-like protein 5synaptotagmin-17B/K proteinsynaptotagmin XVII
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000381414, ENST00000396229, 
ENST00000541464, ENST00000542583, 
ENST00000563675, ENST00000219821, 
ENST00000561503, ENST00000564959, 
ENST00000355377, ENST00000562034, 
ENST00000562711, ENST00000568115, 
ENST00000568433, 
Fusion gene scores* DoF score11 X 9 X 5=4954 X 4 X 3=48
# samples 124
** MAII scorelog2(12/495*10)=-2.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMC5 [Title/Abstract] AND SYT17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMC5(19441962)-SYT17(19234367), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYT17

GO:1903861

positive regulation of dendrite extension

23999003


check buttonFusion gene breakpoints across TMC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SYT17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-4501-01ATMC5chr16

19441962

+SYT17chr16

19234367

+


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Fusion Gene ORF analysis for TMC5-SYT17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000381414ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000381414ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000381414ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000381414ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000381414ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000396229ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000541464ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
5UTR-3CDSENST00000542583ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
In-frameENST00000563675ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
In-frameENST00000563675ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
In-frameENST00000563675ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
In-frameENST00000563675ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
In-frameENST00000563675ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000219821ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000561503ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000355377TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000562034TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000562711TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000568115TMC5chr16

19441962

+SYT17chr16

19234367

+
intron-3CDSENST00000564959ENST00000568433TMC5chr16

19441962

+SYT17chr16

19234367

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000563675TMC5chr1619441962+ENST00000355377SYT17chr1619234367+2001273219746175
ENST00000563675TMC5chr1619441962+ENST00000562034SYT17chr1619234367+799273219746175
ENST00000563675TMC5chr1619441962+ENST00000562711SYT17chr1619234367+778273219746175
ENST00000563675TMC5chr1619441962+ENST00000568433SYT17chr1619234367+789273219746175
ENST00000563675TMC5chr1619441962+ENST00000568115SYT17chr1619234367+688273219683154

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000563675ENST00000355377TMC5chr1619441962+SYT17chr1619234367+0.71634360.28365645
ENST00000563675ENST00000562034TMC5chr1619441962+SYT17chr1619234367+0.357294170.6427058
ENST00000563675ENST00000562711TMC5chr1619441962+SYT17chr1619234367+0.325961050.67403895
ENST00000563675ENST00000568433TMC5chr1619441962+SYT17chr1619234367+0.35738690.6426131
ENST00000563675ENST00000568115TMC5chr1619441962+SYT17chr1619234367+0.59337280.40662715

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Fusion Genomic Features for TMC5-SYT17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMC5chr1619441962+SYT17chr1619234366+0.0002569250.99974304
TMC5chr1619441962+SYT17chr1619234366+0.0002569250.99974304

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMC5-SYT17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:19441962/chr16:19234367)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSYT17chr16:19441962chr16:19234367ENST0000035537748321_455317475.0DomainC2 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118140_1430761.0Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221140_1430949.0Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222140_14301007.0Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222140_14301007.0Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118140_1430648.0Compositional biasNote=Poly-Ser
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+1181_4580761.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118480_4850761.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118509_5250761.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118547_6190761.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118641_6540761.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118676_6980761.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118720_7320761.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118754_7860761.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118808_8350761.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118857_9000761.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118922_10060761.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+2211_4580949.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221480_4850949.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221509_5250949.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221547_6190949.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221641_6540949.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221676_6980949.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221720_7320949.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221754_7860949.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221808_8350949.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221857_9000949.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221922_10060949.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+2221_45801007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222480_48501007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222509_52501007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222547_61901007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222641_65401007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222676_69801007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222720_73201007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222754_78601007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222808_83501007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222857_90001007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222922_100601007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+2221_45801007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222480_48501007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222509_52501007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222547_61901007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222641_65401007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222676_69801007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222720_73201007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222754_78601007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222808_83501007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222857_90001007.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222922_100601007.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+1181_4580648.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118480_4850648.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118509_5250648.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118547_6190648.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118641_6540648.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118676_6980648.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118720_7320648.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118754_7860648.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118808_8350648.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118857_9000648.0Topological domainCytoplasmic
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118922_10060648.0Topological domainExtracellular
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118459_4790761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118486_5080761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118526_5460761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118620_6400761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118655_6750761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118699_7190761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118733_7530761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118787_8070761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118836_8560761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000219821+118901_9210761.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221459_4790949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221486_5080949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221526_5460949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221620_6400949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221655_6750949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221699_7190949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221733_7530949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221787_8070949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221836_8560949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000381414+221901_9210949.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222459_47901007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222486_50801007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222526_54601007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222620_64001007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222655_67501007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222699_71901007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222733_75301007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222787_80701007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222836_85601007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000396229+222901_92101007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222459_47901007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222486_50801007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222526_54601007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222620_64001007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222655_67501007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222699_71901007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222733_75301007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222787_80701007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222836_85601007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000542583+222901_92101007.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118459_4790648.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118486_5080648.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118526_5460648.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118620_6400648.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118655_6750648.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118699_7190648.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118733_7530648.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118787_8070648.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118836_8560648.0TransmembraneHelical
HgeneTMC5chr16:19441962chr16:19234367ENST00000561503+118901_9210648.0TransmembraneHelical
TgeneSYT17chr16:19441962chr16:19234367ENST000003553774823_40317475.0Compositional biasNote=Cys-rich
TgeneSYT17chr16:19441962chr16:19234367ENST0000035537748184_310317475.0DomainC2 1


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Fusion Gene Sequence for TMC5-SYT17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91352_91352_1_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000355377_length(transcript)=2001nt_BP=273nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG
TCTCCTGCCTCCCTGGAGGTGACCTGAGGGCTGCAGGGAAGGCAGCTTTCATTTGTTTAAAAAAAAAAAAAAAAGACGGAAAAAAATGTG
TCACATACTATTACATCCACACCTGCATACACACTCGCAACATGTCTACACACGTCCACACACACAGACACACAGATACCCCAAATCCTC
TCAGAACTGAGAGGAAGCTGACTATTGATCACAAAATGGCCGCCCTCAGTTGAGTGAGGCCTAGGAACTTTCCGGAAGCCCCATCCATAG
ATCACAAGCTCAGTGGGCTCTGCCGTGGGACTTATTGGCAGTGCCTGCTCTTGTCAATACTCCTGCCCCAAAATGCACTTTCAACCCTCA
GGCCAGAGAAAGGACCTCCCAAAGGGTGCCAAGCTCCATCAAGACTAAATTTACCAAGAGTTTGGCCAGTGTGTGGGAGACTTGAACACC
CCCCACTTCCGAAACACACACCTACTGGGTAACTTCTGAACAGGCTGCTGTTCCCTGGGGTTCTTCAAACCTGATACCTTTCTCCAAAGG
TGTAAGTATCTTTGTCTTCTCCGTAGTAAATGTGATAACTAGATTATGGGCCATTTGGAGAAACCAAATGGCAACCAAAACTATTCCAGT
GTCAGAAGCCTTTCCTGGCTTAACAGAATTGTTCTTGTGTTAGCTCATCCCAGGGAACGCCCTGTGGGTATGTATGTGTATGTCCTCGTG
CATGTGCCCTCACAGGCGAACACGTGTGTGCCTATGTGTCCTCTTGGAGAGCATGGCGATGGGCCAGGACCTCAGCCCTGAGCACTGCCT
TCTCTCTGCCTCTCCTGTCCAGTGAGAGTCCAACCAGTGTCCTCCTGTCTGTCAGAGATCCCACTTTGGATAAAAGTAGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTGTAAAGTAAATAGGATATGATAGAGCAAAAGTAACATTTTTTGACCGAATCATGGTGATTGTGACCCA
CGAAAGACATACAAAGACTTGATATATGGATTAAAATGGCTATCACACCCCATCCATGATGATCTTCTTCCTTAATCATACTCTGAGGAT
CTTTCTGTGTTTTTCTGTGAACGAATGTCACGTCTCTCGTGCTAAGGAATTAGTGTAGTTAGAATAGATCTCTCTCTCTCTCTCTTTCTC
TCTCTCTCTTTCCTCTCTCTCTGTTGGATGCTTCTGTATCTTTTTCCACAGCATAATGTCTGGTGTGATGGGGAGCTATTTATTGAAATT

>91352_91352_1_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000355377_length(amino acids)=175AA_BP=18
MHNICIYLGQSKNNKGKKNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYN

--------------------------------------------------------------
>91352_91352_2_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000562034_length(transcript)=799nt_BP=273nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>91352_91352_2_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000562034_length(amino acids)=175AA_BP=18
MHNICIYLGQSKNNKGKKNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYN

--------------------------------------------------------------
>91352_91352_3_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000562711_length(transcript)=778nt_BP=273nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>91352_91352_3_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000562711_length(amino acids)=175AA_BP=18
MHNICIYLGQSKNNKGKKNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYN

--------------------------------------------------------------
>91352_91352_4_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000568115_length(transcript)=688nt_BP=273nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGGATCCAACAGCCCCATACCAGCCTGCGAACTGAGTAGTCACCCAGCTCATGGTATCAGTCCTTGGATACCCTCACCTGGA

>91352_91352_4_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000568115_length(amino acids)=154AA_BP=18
MHNICIYLGQSKNNKGKKNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYN

--------------------------------------------------------------
>91352_91352_5_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000568433_length(transcript)=789nt_BP=273nt
GAGCGCCGCCCCACCCAGGCCTGCGCGGCGTCTGGTGGCCATCAGGACATGAGGCTCTGCCTGCAGTCAGCAACTTGGAATATTCAGACT
TCAGACCAGCATCACAGATTATAACCCTCCGTAAATCATCTGCATCCCAGCTCCCATCAAAAGCCAGCCTGAAGGACCCATGGACACGTG
ACTCCAGTGTTCTCAACAACATCTTAAGATCAAGTTGGTTTGCACAACATTTGCATCTACTTGGGACAAAGCAAGAACAATAAGGGCAAA
AAAAATGAAGTGGAGCTGGGGGAGCTGCTTCTGTCACTGAATTATCTCCCAAGTGCTGGCAGACTGAATGTTGATGTCATTCGAGCCAAG
CAACTTCTTCAGACAGATGTGAGCCAAGGTTCAGACCCCTTTGTGAAAATCCAGCTGGTGCATGGACTCAAACTTGTGAAAACCAAGAAG
ACGTCCTTCTTAAGGGGCACAATTGATCCTTTCTACAATGAATCCTTCAGCTTCAAAGTTCCCCAAGAAGAACTGGAAAATGCCAGCCTA
GTGTTTACAGTTTTCGGCCACAACATGAAGAGCAGCAATGACTTCATCGGGAGGATCGTCATTGGCCAGTACTCTTCAGGCCCCTCTGAG
ACCAACCACTGGAGGCGCATGCTCAACACGCACCGCACAGCCGTGGAGCAGTGGCATAGCCTGAGGTCCCGAGCTGAGTGTGACCGCGTG

>91352_91352_5_TMC5-SYT17_TMC5_chr16_19441962_ENST00000563675_SYT17_chr16_19234367_ENST00000568433_length(amino acids)=175AA_BP=18
MHNICIYLGQSKNNKGKKNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMC5-SYT17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMC5-SYT17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMC5-SYT17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource