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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMC6-UACA (FusionGDB2 ID:91358)

Fusion Gene Summary for TMC6-UACA

check button Fusion gene summary
Fusion gene informationFusion gene name: TMC6-UACA
Fusion gene ID: 91358
HgeneTgene
Gene symbol

TMC6

UACA

Gene ID

100131096

55075

Gene nameTNRC6C antisense RNA 1uveal autoantigen with coiled-coil domains and ankyrin repeats
SynonymsTMC6|lncNUCLING
Cytomap

17q25.3

15q23

Type of genencRNAprotein-coding
Description-uveal autoantigen with coiled-coil domains and ankyrin repeatsnuclear membrane binding protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000306591, ENST00000322914, 
ENST00000322933, ENST00000392467, 
ENST00000589553, ENST00000590602, 
ENST00000591436, ENST00000592076, 
ENST00000559183, ENST00000322954, 
ENST00000379983, ENST00000539319, 
ENST00000560441, 
Fusion gene scores* DoF score5 X 6 X 5=1509 X 8 X 4=288
# samples 69
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMC6 [Title/Abstract] AND UACA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMC6(76118686)-UACA(70970545), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMC6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UACA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8ID-01ATMC6chr17

76118686

-UACAchr15

70970545

-
ChimerDB4PRADTCGA-KK-A8IDTMC6chr17

76118686

-UACAchr15

70970545

-


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Fusion Gene ORF analysis for TMC6-UACA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000306591ENST00000559183TMC6chr17

76118686

-UACAchr15

70970545

-
5CDS-intronENST00000322914ENST00000559183TMC6chr17

76118686

-UACAchr15

70970545

-
5CDS-intronENST00000322933ENST00000559183TMC6chr17

76118686

-UACAchr15

70970545

-
5CDS-intronENST00000392467ENST00000559183TMC6chr17

76118686

-UACAchr15

70970545

-
5CDS-intronENST00000589553ENST00000559183TMC6chr17

76118686

-UACAchr15

70970545

-
5CDS-intronENST00000590602ENST00000559183TMC6chr17

76118686

-UACAchr15

70970545

-
5CDS-intronENST00000591436ENST00000559183TMC6chr17

76118686

-UACAchr15

70970545

-
5UTR-3CDSENST00000592076ENST00000322954TMC6chr17

76118686

-UACAchr15

70970545

-
5UTR-3CDSENST00000592076ENST00000379983TMC6chr17

76118686

-UACAchr15

70970545

-
5UTR-3CDSENST00000592076ENST00000539319TMC6chr17

76118686

-UACAchr15

70970545

-
5UTR-3CDSENST00000592076ENST00000560441TMC6chr17

76118686

-UACAchr15

70970545

-
5UTR-intronENST00000592076ENST00000559183TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000306591ENST00000322954TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000306591ENST00000379983TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000306591ENST00000539319TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000306591ENST00000560441TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000322914ENST00000322954TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000322914ENST00000379983TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000322914ENST00000539319TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000322914ENST00000560441TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000322933ENST00000322954TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000322933ENST00000379983TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000322933ENST00000539319TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000322933ENST00000560441TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000589553ENST00000322954TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000589553ENST00000379983TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000589553ENST00000539319TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000589553ENST00000560441TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000590602ENST00000322954TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000590602ENST00000379983TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000590602ENST00000539319TMC6chr17

76118686

-UACAchr15

70970545

-
Frame-shiftENST00000590602ENST00000560441TMC6chr17

76118686

-UACAchr15

70970545

-
In-frameENST00000392467ENST00000322954TMC6chr17

76118686

-UACAchr15

70970545

-
In-frameENST00000392467ENST00000379983TMC6chr17

76118686

-UACAchr15

70970545

-
In-frameENST00000392467ENST00000539319TMC6chr17

76118686

-UACAchr15

70970545

-
In-frameENST00000392467ENST00000560441TMC6chr17

76118686

-UACAchr15

70970545

-
In-frameENST00000591436ENST00000322954TMC6chr17

76118686

-UACAchr15

70970545

-
In-frameENST00000591436ENST00000379983TMC6chr17

76118686

-UACAchr15

70970545

-
In-frameENST00000591436ENST00000539319TMC6chr17

76118686

-UACAchr15

70970545

-
In-frameENST00000591436ENST00000560441TMC6chr17

76118686

-UACAchr15

70970545

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392467TMC6chr1776118686-ENST00000322954UACAchr1570970545-7277141517647741532
ENST00000392467TMC6chr1776118686-ENST00000539319UACAchr1570970545-4854141517647741532
ENST00000392467TMC6chr1776118686-ENST00000379983UACAchr1570970545-5029141517647741532
ENST00000392467TMC6chr1776118686-ENST00000560441UACAchr1570970545-4893141517647681530
ENST00000591436TMC6chr1776118686-ENST00000322954UACAchr1570970545-6006144035031167
ENST00000591436TMC6chr1776118686-ENST00000539319UACAchr1570970545-3583144035031167
ENST00000591436TMC6chr1776118686-ENST00000379983UACAchr1570970545-3758144035031167
ENST00000591436TMC6chr1776118686-ENST00000560441UACAchr1570970545-3622144034971165

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392467ENST00000322954TMC6chr1776118686-UACAchr1570970545-0.0007986120.99920136
ENST00000392467ENST00000539319TMC6chr1776118686-UACAchr1570970545-0.0029773990.99702257
ENST00000392467ENST00000379983TMC6chr1776118686-UACAchr1570970545-0.0023402160.9976598
ENST00000392467ENST00000560441TMC6chr1776118686-UACAchr1570970545-0.0027462940.9972537
ENST00000591436ENST00000322954TMC6chr1776118686-UACAchr1570970545-0.0005871950.9994128
ENST00000591436ENST00000539319TMC6chr1776118686-UACAchr1570970545-0.0036204050.99637955
ENST00000591436ENST00000379983TMC6chr1776118686-UACAchr1570970545-0.0025175490.9974825
ENST00000591436ENST00000560441TMC6chr1776118686-UACAchr1570970545-0.0032320450.996768

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Fusion Genomic Features for TMC6-UACA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMC6-UACA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:76118686/chr15:70970545)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-10121_209409455.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012231_249409455.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012271_338409455.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-10201_209409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020231_249409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020271_338409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-9191_209409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919231_249409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919271_338409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-10201_209409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020231_249409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020271_338409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012210_230409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012250_270409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012339_359409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020210_230409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020250_270409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020339_359409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919210_230409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919250_270409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919339_359409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020210_230409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020250_270409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020339_359409806.0TransmembraneHelical
TgeneUACAchr17:76118686chr15:70970545ENST00000322954919438_13862971417.0Coiled coilOntology_term=ECO:0000255
TgeneUACAchr17:76118686chr15:70970545ENST00000379983919286_3742841404.0Coiled coilOntology_term=ECO:0000255
TgeneUACAchr17:76118686chr15:70970545ENST00000379983919438_13862841404.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012360_431409455.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012453_469409455.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012491_505409455.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012527_553409455.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012575_604409455.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012626_650409455.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012672_722409455.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012744_805409455.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020360_431409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020453_469409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020491_505409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020527_553409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020575_604409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020626_650409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020672_722409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020744_805409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-10191_20948385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019231_24948385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019271_33848385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019360_43148385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019453_46948385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019491_50548385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019527_55348385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019575_60448385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019626_65048385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019672_72248385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019744_80548385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919360_431409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919453_469409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919491_505409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919527_553409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919575_604409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919626_650409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919672_722409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919744_805409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-8101_209182299.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810231_249182299.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810271_338182299.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810360_431182299.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810453_469182299.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810491_505182299.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810527_553182299.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810575_604182299.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810626_650182299.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810672_722182299.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810744_805182299.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020360_431409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020453_469409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020491_505409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020527_553409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020575_604409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020626_650409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020672_722409806.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020744_805409806.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-1101_20948385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110231_24948385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110271_33848385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110360_43148385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110453_46948385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110491_50548385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110527_55348385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110575_60448385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110626_65048385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110672_72248385.0Topological domainCytoplasmic
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110744_80548385.0Topological domainLumenal
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012432_452409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012470_490409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012506_526409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012554_574409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012605_625409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012651_671409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000306591-1012723_743409455.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020432_452409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020470_490409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020506_526409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020554_574409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020605_625409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020651_671409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322914-1020723_743409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019210_23048385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019250_27048385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019339_35948385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019432_45248385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019470_49048385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019506_52648385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019554_57448385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019605_62548385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019651_67148385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000322933-1019723_74348385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919432_452409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919470_490409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919506_526409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919554_574409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919605_625409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919651_671409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000392467-919723_743409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810210_230182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810250_270182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810339_359182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810432_452182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810470_490182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810506_526182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810554_574182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810605_625182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810651_671182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000589553-810723_743182299.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020432_452409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020470_490409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020506_526409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020554_574409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020605_625409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020651_671409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000590602-1020723_743409806.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110210_23048385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110250_27048385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110339_35948385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110432_45248385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110470_49048385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110506_52648385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110554_57448385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110605_62548385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110651_67148385.0TransmembraneHelical
HgeneTMC6chr17:76118686chr15:70970545ENST00000591436-110723_74348385.0TransmembraneHelical
TgeneUACAchr17:76118686chr15:70970545ENST00000322954919286_3742971417.0Coiled coilOntology_term=ECO:0000255
TgeneUACAchr17:76118686chr15:70970545ENST0000032295491921_292971417.0Compositional biasNote=Poly-Ala
TgeneUACAchr17:76118686chr15:70970545ENST0000037998391921_292841404.0Compositional biasNote=Poly-Ala
TgeneUACAchr17:76118686chr15:70970545ENST00000322954919100_1292971417.0RepeatNote=ANK 3
TgeneUACAchr17:76118686chr15:70970545ENST00000322954919133_1622971417.0RepeatNote=ANK 4
TgeneUACAchr17:76118686chr15:70970545ENST00000322954919166_1952971417.0RepeatNote=ANK 5
TgeneUACAchr17:76118686chr15:70970545ENST00000322954919199_2282971417.0RepeatNote=ANK 6
TgeneUACAchr17:76118686chr15:70970545ENST0000032295491938_662971417.0RepeatNote=ANK 1
TgeneUACAchr17:76118686chr15:70970545ENST0000032295491967_962971417.0RepeatNote=ANK 2
TgeneUACAchr17:76118686chr15:70970545ENST00000379983919100_1292841404.0RepeatNote=ANK 3
TgeneUACAchr17:76118686chr15:70970545ENST00000379983919133_1622841404.0RepeatNote=ANK 4
TgeneUACAchr17:76118686chr15:70970545ENST00000379983919166_1952841404.0RepeatNote=ANK 5
TgeneUACAchr17:76118686chr15:70970545ENST00000379983919199_2282841404.0RepeatNote=ANK 6
TgeneUACAchr17:76118686chr15:70970545ENST0000037998391938_662841404.0RepeatNote=ANK 1
TgeneUACAchr17:76118686chr15:70970545ENST0000037998391967_962841404.0RepeatNote=ANK 2


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Fusion Gene Sequence for TMC6-UACA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91358_91358_1_TMC6-UACA_TMC6_chr17_76118686_ENST00000392467_UACA_chr15_70970545_ENST00000322954_length(transcript)=7277nt_BP=1415nt
GCGGGACTGTCTGGGCTGTGAGTGGCACCTCCTGTGGTTCCCCCAGGAATGGGTGGTGTGGACAGCTGCCAGGCGTTGAAGACCACCCCT
GGCTCTGTGCCCCTGTCTCATCAGATGGGGGCTCCGGAGGTGGCGCCCAGGCTCTGAGCTACCCTAGGTCTGCAGACTAGCGGGCATTGG
CCAGAGACATGGCCCAGCCACTGGCCTTCATCCTCGATGTCCCTGAGACCCCAGGGGACCAGGGCCAGGGCCCCAGCCCCTATGATGAAA
GCGAAGTGCACGACTCCTTCCAGCAGCTCATCCAGGAGCAGAGCCAGTGCACGGCCCAGGAGGGGCTGGAGCTGCAGCAGAGAGAGCGGG
AGGTGACAGGAAGTAGCCAGCAGACACTCTGGCGGCCCGAGGGCACCCAGAGCACGGCCACACTCCGCATCCTGGCCAGCATGCCCAGCC
GCACCATTGGCCGCAGCCGAGGTGCCATCATCTCCCAGTACTACAACCGCACGGTGCAGCTTCGGTGCAGGAGCAGCCGGCCCCTGCTCG
GGAACTTTGTCCGCTCCGCCTGGCCCAGCCTCCGCCTGTACGACCTGGAGCTGGACCCCACGGCCCTGGAGGAGGAGGAGAAGCAGAGCC
TCCTGGTGAAGGAGCTCCAGAGCCTGGCAGTGGCACAGCGGGACCACATGCTTCGCGGGATGCCCTTAAGCCTGGCTGAGAAACGCAGCC
TGCGAGAGAAGAGCAGGACCCCGAGGGGGAAGTGGAGGGGCCAGCCGGGCAGCGGCGGGGTCTGCTCCTGCTGTGGCCGGCTCAGATATG
CCTGCGTGCTGGCCTTGCACAGCCTGGGCCTGGCGCTGCTCTCCGCCCTGCAGGCCCTGATGCCGTGGCGCTACGCCCTGAAGCGCATCG
GGGGCCAGTTCGGCTCCAGCGTGCTCTCCTACTTCCTCTTTCTCAAGACCCTGCTGGCTTTCAATGCCCTCCTGCTGCTGCTGCTGGTGG
CCTTCATCATGGGCCCTCAGGTCGCCTTCCCACCCGCCCTGCCGGGCCCTGCCCCCGTCTGCACAGGCCTGGAGCTCCTCACAGGCGCGG
GTTGCTTCACCCACACCGTCATGTACTACGGCCACTACAGTAACGCCACGCTGAACCAGCCGTGTGGCAGCCCCCTGGATGGCAGCCAGT
GCACACCCAGGGTGGGTGGCCTGCCCTACAACATGCCCCTGGCCTACCTCTCCACTGTGGGCGTGAGCTTCTTTATCACCTGCATCACCC
TGGTGTACAGCATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGCAGCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGG
ACTACAAGGTGACGCAGAAGCGGGCCTCCCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGATTTGGAGATTGAAAATGAAGATT
TGAAAGAGAGGTTGAGAAAAATTCAGCAAGAACAAAGAATACTTTTGGATAAAGTCAATGGTTTACAGTTACAGCTGAATGAGGAAGTTA
TGGTTGCTGATGATCTGGAAAGCGAGAGAGAAAAGCTGAAGTCCCTTTTGGCAGCTAAAGAAAAGCAACATGAAGAAAGCTTAAGGACTA
TTGAGGCTCTGAAAAATAGATTTAAATATTTTGAGAGTGATCATTTAGGATCAGGAAGTCATTTCAGTAACCGAAAAGAAGATATGCTTC
TTAAACAAGGTCAGATGTATATGGCAGACTCACAGTGTACTTCCCCAGGTATACCAGCCCATATGCAAAGCAGATCTATGTTAAGACCTC
TGGAACTATCTTTACCCAGTCAAACGTCATACTCTGAAAATGAAATTTTAAAGAAAGAGTTAGAAGCAATGCGAACTTTCTGTGAGTCAG
CAAAACAAGACCGACTGAAGCTCCAAAATGAACTGGCACACAAAGTGGCAGAATGCAAAGCTTTAGCATTAGAATGTGAAAGGGTCAAGG
AGGATTCAGATGAACAGATAAAGCAATTAGAAGATGCATTAAAAGATGTGCAGAAGAGGATGTATGAGTCAGAAGGTAAAGTTAAACAAA
TGCAGACCCATTTTCTTGCCCTTAAAGAACACTTAACAAGTGAAGCAGCCTCAGGGAATCACAGACTAACCGAGGAACTGAAGGATCAGT
TGAAAGACTTGAAAGTAAAATATGAAGGTGCTTCAGCAGAAGTGGGGAAATTAAGAAACCAAATCAAACAAAATGAGATGATAGTAGAAG
AGTTTAAGAGGGATGAAGGCAAGCTGATAGAAGAAAATAAGCGATTACAGAAGGAACTTAGTATGTGTGAAATGGAGCGAGAGAAGAAAG
GAAGAAAGGTCACAGAGATGGAAGGCCAGGCAAAAGAATTGTCAGCGAAGTTGGCCCTTTCCATTCCAGCTGAAAAATTTGAAAACATGA
AGAGCTCATTATCAAATGAAGTGAATGAGAAAGCAAAAAAATTAGTAGAAATGGAAAGAGAACATGAAAAATCACTTAGTGAAATTAGAC
AGTTAAAGAGAGAACTTGAGAATGTTAAGGCCAAGCTTGCTCAGCACGTCAAACCAGAGGAACATGAACAGGTTAAGAGCAGATTAGAAC
AGAAATCAGGAGAACTTGGGAAGAAGATCACTGAGTTAACATTGAAAAATCAGACACTACAAAAGGAAATTGAAAAAGTTTATTTGGATA
ATAAGCTCCTCAAGGAGCAAGCACATAACTTAACAATTGAAATGAAAAATCATTATGTTCCTTTAAAAGTAAGTGAAGACATGAAAAAGT
CACATGATGCAATTATTGATGATCTTAATAGAAAGCTTTTAGATGTAACACAAAAATATACAGAAAAGAAGTTGGAAATGGAGAAATTGC
TACTGGAAAATGACAGCTTAAGTAAGGATGTAAGCCGCCTAGAAACTGTGTTTGTACCTCCTGAGAAACATGAAAAAGAGATAATAGCTC
TGAAATCCAATATTGTTGAACTTAAGAAACAGCTGTCTGAACTTAAGAAAAAATGTGGTGAAGACCAGGAGAAAATACACGCTCTCACAT
CTGAAAACACTAACTTGAAGAAGATGATGAGTAATCAGTATGTGCCAGTTAAAACCCATGAAGAGGTTAAAATGACACTGAATGACACGT
TAGCCAAAACTAACAGAGAATTATTAGATGTGAAGAAAAAATTTGAAGATATAAATCAGGAATTTGTAAAAATAAAAGATAAGAATGAAA
TATTAAAAAGAAACCTGGAAAACACTCAGAACCAAATAAAAGCTGAGTACATCAGCCTGGCAGAGCACGAGGCAAAGATGAGCTCGCTAA
GTCAGAGCATGAGAAAGGTGCAGGATAGTAATGCTGAAATCTTGGCCAACTACAGAAAAGGCCAAGAAGAGATTGTGACACTGCATGCCG
AAATTAAAGCCCAGAAGAAGGAGCTCGACACAATACAAGAATGCATTAAGGTAAAATACGCCCCAATTGTCAGCTTTGAGGAGTGCGAGA
GAAAATTTAAAGCAACAGAGAAAGAACTAAAAGACCAGTTATCAGAGCAGACACAAAAGTATAGTGTCAGTGAAGAAGAAGTCAAGAAAA
ACAAGCAAGAGAATGACAAGTTAAAGAAGGAGATTTTTACCCTTCAGAAAGATTTGAGAGATAAGACAGTTCTCATTGAGAAGTCTCATG
AAATGGAAAGAGCATTAAGCAGAAAAACAGACGAGCTAAACAAACAGTTAAAAGACTTGTCACAGAAATACACGGAAGTAAAGAATGTGA
AAGAGAAGCTAGTAGAAGAAAATGCCAAACAGACTTCTGAGATACTTGCAGTGCAAAATCTTTTGCAAAAACAACATGTTCCATTGGAAC
AGGTTGAGGCTCTGAAAAAATCTCTTAATGGCACAATTGAAAATCTAAAGGAAGAACTGAAGAGTATGCAAAGGTGTTACGAGAAAGAGC
AGCAGACAGTGACCAAACTGCATCAATTGTTGGAGAATCAAAAGAACTCTTCTGTACCCCTGGCAGAGCATTTGCAGATTAAAGAAGCAT
TTGAGAAAGAAGTTGGAATCATAAAAGCCAGCTTGAGAGAAAAGGAAGAAGAAAGCCAAAACAAAATGGAAGAAGTCTCCAAACTTCAGT
CGGAGGTTCAGAATACTAAACAAGCATTAAAAAAATTAGAGACTAGAGAGGTAGTTGACTTGTCTAAATATAAAGCAACAAAAAGTGATT
TGGAGACACAGATTTCTAGCTTAAATGAAAAATTGGCCAATCTGAATAGAAAGTATGAGGAAGTATGTGAGGAAGTTTTGCATGCCAAAA
AGAAGGAAATATCTGCAAAAGATGAGAAGGAATTACTGCATTTCAGCATTGAGCAAGAAATTAAGGATCAGAAGGAACGATGTGATAAGT
CCTTAACAACAATCACAGAGTTACAAAGAAGAATACAAGAATCTGCTAAACAAATAGAAGCAAAAGATAATAAGATAACTGAACTGCTTA
ATGATGTGGAAAGATTAAAACAGGCACTCAATGGCCTTTCCCAACTCACCTACACAAGTGGGAACCCCACCAAGAGGCAGAGCCAGCTGA
TTGACACTCTGCAGCACCAAGTGAAATCTCTGGAGCAACAGCTGGCCGATGCTGACAGACAGCACCAAGAAGTAATTGCAATTTATCGGA
CACACCTTCTTAGTGCTGCACAGGGTCACATGGATGAAGATGTTCAGGAGGCTCTGCTCCAGATCATACAAATGCGGCAGGGGCTTGTGT
GCTAGCCGTTAGCACTGACTGCCAGTATCTGTTTTATCTTGCTGGTGCTGAACATTCTTTGTGCAACTCCATGGTCTTTCTGGGCCTTAC
TGTGCTGGTATAATTAAAATAAAATATATTTTGTTCTATTGGTAGGTTTTTTTTTAAAATTAGATGAATATGTTAGTCTTTTTCAATATC
AGTTTGAATCTTATTTTCTGTATGTGTTAATTTTACAAATAGGCAAACAACATAACTTTGCCCTGGATTGACTACATATTTTTAAACCTT
CAAGTCCCTAATAAAACATGAGCCATCTGAGTGAGTCCATATGAAGCGAGGTTAGGCTGAAATAATTGCTTAAAGATGTCTTTCAGAGAA
ATTAATTTGGTTGGTGGCCACTTTTAGGTGGATCAAAAGACCTTTCAGATCCTCAGAACCTTGAGACATAATACAGTTGTGAGGAATGTG
TTGTAACTTGGCTGGCCAAGTTACATGTTACAGTATCTTTACTGAGGTAACTTCATTAGTGTCTTTGGCCTTTTTTGTAGGTATAGATAT
TTTTTCTTTTTACACTAATAACTTTTATGCCTTTTAAAATAAATTTATTTTCATAAATGGTTTGCAGTGCTAAATTACATTTAGATTAAG
AACAGGCAGGGGTGGAATATATCAGGAATTTATAATAAAATTGCCTTAATCTCTACAACAGTATCTTAATTTTTACTTGCGGTGACTATT
CTTGCCACAATATTGGAGAATAATGATAGATGATATACTAGATTTTTCAAAGTGTGAAAACCTTTAGACTTTTTTTAGCAATTAGTTTGA
CATTCGCTACTATAGTAACCAAGCACTCATTATATATGCATCCTCCAAATGTTTCATGCTTATTTATAGGAAAGTTATATTAATGAGATT
AATAATGTGAAATACAGTTTTCCTGCAAAATTAGCATTAGAGAATTGATTTTAGATAACAGATTTTTAAAGTTTTAGAGAAAAGTACAGT
AATACAGTAAACTGAAAGAGTATATAGATAGCAATAAAATAACATAAGTGGACATGTTTATAGTAAATACTCTGAAGTAAACAACCGTTT
TTATTAACTGCATCTCATTAGGGAAAGTTTATATGTCTTGTTATTTTTTATTAACATTTTATTTACCATTCAGAGTGAAAATTACTAATT
TGAGTATTAACAAATAACTGAATAAATGGATCATTACAGTTAGGTTTTCTCAAATTGCAAAATTTGCCTTAGCAATTATCTTTGAACATC
CCGAACCAGATTTTTAAATCCCATTTTTGTTTAATAGGGTAAAAATACCATCAAAATGACTTCTCATACCAAAGAATAAGCCATCATATT
TTTTCGGTGTTGAAACAACATTGAAAGTCAGAATTGGATTTGTTTTTAATTCTTTATACGGTTTACATAAGCAATATCTGTCTCTTTAAT
TATTATGATTAATGTCGTCCTTCAGCATGAGTTCTGTTTCACAAGTTTTGGGCCACCTATTTCAATAAAAAATAAAATATAAATTAAAAA
AGTTGCCGGGGGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGAGGTAGATCACCTGAGGTCAGAAGTTCGAGACCA
GCCTTACCAATATGGTGAAGCCCCATCTCTACTAAAAATACAAAAATTAGCCCTGCATGGTGGCAGGTGCCTGTAGTCCCAGGTACTCGG
GAGGCTGAGACAGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATCTCGCCACTGCACTCCAGCTTGGGCAATAGC
AAGACTCCATCTCAAAATAAAATAAAATAAAACTTAGAGCAAAGTTTAAAACTGAGTATTCATATTAAGTGTTTTATTTTCCATATTAGA
GATGGGAAGGGAACCTTATGTGTATTTTATTTTGTTTTCAACCATCAATAAAGTTTTCTCTAGAATATTGTTTTGAACATCCTTGTAAAA
GATTTGCGAGTTAAACTATTTTATTTACTGTCTGTGAGAGCATTGGGAGTAGGAAACGATGGACTCCAAAGTACAAGGGAGAATACCCAT
TTTCATTCAGCTATCTGGAGTAAAATATCAAGTACTTCCTTCAACTAATCTTGTCTCATTCACTCACCTTTTGATATCGAAGGCAGAAAT
TGCGTTTACAACACTGAAGACCAAAGCTTTTTAATTAGTAAACAAGCGGAACATAGATAATGGACAATGCTGGCCACTGCCATTCTGTGT
TCAGAAAGACTATGAGACCTGAACATATGGCCAAGAGGAAAGAAGAGTGACGTTGTCTAAGATGTAATGAGTGCTCTCTGAGAGAATCAC
TCAATTCCTATTGGAGTGCAATCCTTACTTGAGAACTTTATTACTCTTGTTCTGTGTAGTTTTTTTTTTTTGTCACTTCCCCATCAGAAA

>91358_91358_1_TMC6-UACA_TMC6_chr17_76118686_ENST00000392467_UACA_chr15_70970545_ENST00000322954_length(amino acids)=1532AA_BP=412
MARDMAQPLAFILDVPETPGDQGQGPSPYDESEVHDSFQQLIQEQSQCTAQEGLELQQREREVTGSSQQTLWRPEGTQSTATLRILASMP
SRTIGRSRGAIISQYYNRTVQLRCRSSRPLLGNFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPLSLAEKR
SLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLL
VAFIMGPQVAFPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFFITCI
TLVYSMAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEE
VMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLR
PLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVK
QMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK
KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL
EQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK
LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND
TLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLH
AEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS
HEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEK
EQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKS
DLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITEL
LNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL

--------------------------------------------------------------
>91358_91358_2_TMC6-UACA_TMC6_chr17_76118686_ENST00000392467_UACA_chr15_70970545_ENST00000379983_length(transcript)=5029nt_BP=1415nt
GCGGGACTGTCTGGGCTGTGAGTGGCACCTCCTGTGGTTCCCCCAGGAATGGGTGGTGTGGACAGCTGCCAGGCGTTGAAGACCACCCCT
GGCTCTGTGCCCCTGTCTCATCAGATGGGGGCTCCGGAGGTGGCGCCCAGGCTCTGAGCTACCCTAGGTCTGCAGACTAGCGGGCATTGG
CCAGAGACATGGCCCAGCCACTGGCCTTCATCCTCGATGTCCCTGAGACCCCAGGGGACCAGGGCCAGGGCCCCAGCCCCTATGATGAAA
GCGAAGTGCACGACTCCTTCCAGCAGCTCATCCAGGAGCAGAGCCAGTGCACGGCCCAGGAGGGGCTGGAGCTGCAGCAGAGAGAGCGGG
AGGTGACAGGAAGTAGCCAGCAGACACTCTGGCGGCCCGAGGGCACCCAGAGCACGGCCACACTCCGCATCCTGGCCAGCATGCCCAGCC
GCACCATTGGCCGCAGCCGAGGTGCCATCATCTCCCAGTACTACAACCGCACGGTGCAGCTTCGGTGCAGGAGCAGCCGGCCCCTGCTCG
GGAACTTTGTCCGCTCCGCCTGGCCCAGCCTCCGCCTGTACGACCTGGAGCTGGACCCCACGGCCCTGGAGGAGGAGGAGAAGCAGAGCC
TCCTGGTGAAGGAGCTCCAGAGCCTGGCAGTGGCACAGCGGGACCACATGCTTCGCGGGATGCCCTTAAGCCTGGCTGAGAAACGCAGCC
TGCGAGAGAAGAGCAGGACCCCGAGGGGGAAGTGGAGGGGCCAGCCGGGCAGCGGCGGGGTCTGCTCCTGCTGTGGCCGGCTCAGATATG
CCTGCGTGCTGGCCTTGCACAGCCTGGGCCTGGCGCTGCTCTCCGCCCTGCAGGCCCTGATGCCGTGGCGCTACGCCCTGAAGCGCATCG
GGGGCCAGTTCGGCTCCAGCGTGCTCTCCTACTTCCTCTTTCTCAAGACCCTGCTGGCTTTCAATGCCCTCCTGCTGCTGCTGCTGGTGG
CCTTCATCATGGGCCCTCAGGTCGCCTTCCCACCCGCCCTGCCGGGCCCTGCCCCCGTCTGCACAGGCCTGGAGCTCCTCACAGGCGCGG
GTTGCTTCACCCACACCGTCATGTACTACGGCCACTACAGTAACGCCACGCTGAACCAGCCGTGTGGCAGCCCCCTGGATGGCAGCCAGT
GCACACCCAGGGTGGGTGGCCTGCCCTACAACATGCCCCTGGCCTACCTCTCCACTGTGGGCGTGAGCTTCTTTATCACCTGCATCACCC
TGGTGTACAGCATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGCAGCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGG
ACTACAAGGTGACGCAGAAGCGGGCCTCCCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGATTTGGAGATTGAAAATGAAGATT
TGAAAGAGAGGTTGAGAAAAATTCAGCAAGAACAAAGAATACTTTTGGATAAAGTCAATGGTTTACAGTTACAGCTGAATGAGGAAGTTA
TGGTTGCTGATGATCTGGAAAGCGAGAGAGAAAAGCTGAAGTCCCTTTTGGCAGCTAAAGAAAAGCAACATGAAGAAAGCTTAAGGACTA
TTGAGGCTCTGAAAAATAGATTTAAATATTTTGAGAGTGATCATTTAGGATCAGGAAGTCATTTCAGTAACCGAAAAGAAGATATGCTTC
TTAAACAAGGTCAGATGTATATGGCAGACTCACAGTGTACTTCCCCAGGTATACCAGCCCATATGCAAAGCAGATCTATGTTAAGACCTC
TGGAACTATCTTTACCCAGTCAAACGTCATACTCTGAAAATGAAATTTTAAAGAAAGAGTTAGAAGCAATGCGAACTTTCTGTGAGTCAG
CAAAACAAGACCGACTGAAGCTCCAAAATGAACTGGCACACAAAGTGGCAGAATGCAAAGCTTTAGCATTAGAATGTGAAAGGGTCAAGG
AGGATTCAGATGAACAGATAAAGCAATTAGAAGATGCATTAAAAGATGTGCAGAAGAGGATGTATGAGTCAGAAGGTAAAGTTAAACAAA
TGCAGACCCATTTTCTTGCCCTTAAAGAACACTTAACAAGTGAAGCAGCCTCAGGGAATCACAGACTAACCGAGGAACTGAAGGATCAGT
TGAAAGACTTGAAAGTAAAATATGAAGGTGCTTCAGCAGAAGTGGGGAAATTAAGAAACCAAATCAAACAAAATGAGATGATAGTAGAAG
AGTTTAAGAGGGATGAAGGCAAGCTGATAGAAGAAAATAAGCGATTACAGAAGGAACTTAGTATGTGTGAAATGGAGCGAGAGAAGAAAG
GAAGAAAGGTCACAGAGATGGAAGGCCAGGCAAAAGAATTGTCAGCGAAGTTGGCCCTTTCCATTCCAGCTGAAAAATTTGAAAACATGA
AGAGCTCATTATCAAATGAAGTGAATGAGAAAGCAAAAAAATTAGTAGAAATGGAAAGAGAACATGAAAAATCACTTAGTGAAATTAGAC
AGTTAAAGAGAGAACTTGAGAATGTTAAGGCCAAGCTTGCTCAGCACGTCAAACCAGAGGAACATGAACAGGTTAAGAGCAGATTAGAAC
AGAAATCAGGAGAACTTGGGAAGAAGATCACTGAGTTAACATTGAAAAATCAGACACTACAAAAGGAAATTGAAAAAGTTTATTTGGATA
ATAAGCTCCTCAAGGAGCAAGCACATAACTTAACAATTGAAATGAAAAATCATTATGTTCCTTTAAAAGTAAGTGAAGACATGAAAAAGT
CACATGATGCAATTATTGATGATCTTAATAGAAAGCTTTTAGATGTAACACAAAAATATACAGAAAAGAAGTTGGAAATGGAGAAATTGC
TACTGGAAAATGACAGCTTAAGTAAGGATGTAAGCCGCCTAGAAACTGTGTTTGTACCTCCTGAGAAACATGAAAAAGAGATAATAGCTC
TGAAATCCAATATTGTTGAACTTAAGAAACAGCTGTCTGAACTTAAGAAAAAATGTGGTGAAGACCAGGAGAAAATACACGCTCTCACAT
CTGAAAACACTAACTTGAAGAAGATGATGAGTAATCAGTATGTGCCAGTTAAAACCCATGAAGAGGTTAAAATGACACTGAATGACACGT
TAGCCAAAACTAACAGAGAATTATTAGATGTGAAGAAAAAATTTGAAGATATAAATCAGGAATTTGTAAAAATAAAAGATAAGAATGAAA
TATTAAAAAGAAACCTGGAAAACACTCAGAACCAAATAAAAGCTGAGTACATCAGCCTGGCAGAGCACGAGGCAAAGATGAGCTCGCTAA
GTCAGAGCATGAGAAAGGTGCAGGATAGTAATGCTGAAATCTTGGCCAACTACAGAAAAGGCCAAGAAGAGATTGTGACACTGCATGCCG
AAATTAAAGCCCAGAAGAAGGAGCTCGACACAATACAAGAATGCATTAAGGTAAAATACGCCCCAATTGTCAGCTTTGAGGAGTGCGAGA
GAAAATTTAAAGCAACAGAGAAAGAACTAAAAGACCAGTTATCAGAGCAGACACAAAAGTATAGTGTCAGTGAAGAAGAAGTCAAGAAAA
ACAAGCAAGAGAATGACAAGTTAAAGAAGGAGATTTTTACCCTTCAGAAAGATTTGAGAGATAAGACAGTTCTCATTGAGAAGTCTCATG
AAATGGAAAGAGCATTAAGCAGAAAAACAGACGAGCTAAACAAACAGTTAAAAGACTTGTCACAGAAATACACGGAAGTAAAGAATGTGA
AAGAGAAGCTAGTAGAAGAAAATGCCAAACAGACTTCTGAGATACTTGCAGTGCAAAATCTTTTGCAAAAACAACATGTTCCATTGGAAC
AGGTTGAGGCTCTGAAAAAATCTCTTAATGGCACAATTGAAAATCTAAAGGAAGAACTGAAGAGTATGCAAAGGTGTTACGAGAAAGAGC
AGCAGACAGTGACCAAACTGCATCAATTGTTGGAGAATCAAAAGAACTCTTCTGTACCCCTGGCAGAGCATTTGCAGATTAAAGAAGCAT
TTGAGAAAGAAGTTGGAATCATAAAAGCCAGCTTGAGAGAAAAGGAAGAAGAAAGCCAAAACAAAATGGAAGAAGTCTCCAAACTTCAGT
CGGAGGTTCAGAATACTAAACAAGCATTAAAAAAATTAGAGACTAGAGAGGTAGTTGACTTGTCTAAATATAAAGCAACAAAAAGTGATT
TGGAGACACAGATTTCTAGCTTAAATGAAAAATTGGCCAATCTGAATAGAAAGTATGAGGAAGTATGTGAGGAAGTTTTGCATGCCAAAA
AGAAGGAAATATCTGCAAAAGATGAGAAGGAATTACTGCATTTCAGCATTGAGCAAGAAATTAAGGATCAGAAGGAACGATGTGATAAGT
CCTTAACAACAATCACAGAGTTACAAAGAAGAATACAAGAATCTGCTAAACAAATAGAAGCAAAAGATAATAAGATAACTGAACTGCTTA
ATGATGTGGAAAGATTAAAACAGGCACTCAATGGCCTTTCCCAACTCACCTACACAAGTGGGAACCCCACCAAGAGGCAGAGCCAGCTGA
TTGACACTCTGCAGCACCAAGTGAAATCTCTGGAGCAACAGCTGGCCGATGCTGACAGACAGCACCAAGAAGTAATTGCAATTTATCGGA
CACACCTTCTTAGTGCTGCACAGGGTCACATGGATGAAGATGTTCAGGAGGCTCTGCTCCAGATCATACAAATGCGGCAGGGGCTTGTGT
GCTAGCCGTTAGCACTGACTGCCAGTATCTGTTTTATCTTGCTGGTGCTGAACATTCTTTGTGCAACTCCATGGTCTTTCTGGGCCTTAC
TGTGCTGGTATAATTAAAATAAAATATATTTTGTTCTATTGGTAGGTTTTTTTTTAAAATTAGATGAATATGTTAGTCTTTTTCAATATC

>91358_91358_2_TMC6-UACA_TMC6_chr17_76118686_ENST00000392467_UACA_chr15_70970545_ENST00000379983_length(amino acids)=1532AA_BP=412
MARDMAQPLAFILDVPETPGDQGQGPSPYDESEVHDSFQQLIQEQSQCTAQEGLELQQREREVTGSSQQTLWRPEGTQSTATLRILASMP
SRTIGRSRGAIISQYYNRTVQLRCRSSRPLLGNFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPLSLAEKR
SLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLL
VAFIMGPQVAFPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFFITCI
TLVYSMAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEE
VMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLR
PLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVK
QMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK
KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL
EQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK
LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND
TLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLH
AEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS
HEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEK
EQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKS
DLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITEL
LNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL

--------------------------------------------------------------
>91358_91358_3_TMC6-UACA_TMC6_chr17_76118686_ENST00000392467_UACA_chr15_70970545_ENST00000539319_length(transcript)=4854nt_BP=1415nt
GCGGGACTGTCTGGGCTGTGAGTGGCACCTCCTGTGGTTCCCCCAGGAATGGGTGGTGTGGACAGCTGCCAGGCGTTGAAGACCACCCCT
GGCTCTGTGCCCCTGTCTCATCAGATGGGGGCTCCGGAGGTGGCGCCCAGGCTCTGAGCTACCCTAGGTCTGCAGACTAGCGGGCATTGG
CCAGAGACATGGCCCAGCCACTGGCCTTCATCCTCGATGTCCCTGAGACCCCAGGGGACCAGGGCCAGGGCCCCAGCCCCTATGATGAAA
GCGAAGTGCACGACTCCTTCCAGCAGCTCATCCAGGAGCAGAGCCAGTGCACGGCCCAGGAGGGGCTGGAGCTGCAGCAGAGAGAGCGGG
AGGTGACAGGAAGTAGCCAGCAGACACTCTGGCGGCCCGAGGGCACCCAGAGCACGGCCACACTCCGCATCCTGGCCAGCATGCCCAGCC
GCACCATTGGCCGCAGCCGAGGTGCCATCATCTCCCAGTACTACAACCGCACGGTGCAGCTTCGGTGCAGGAGCAGCCGGCCCCTGCTCG
GGAACTTTGTCCGCTCCGCCTGGCCCAGCCTCCGCCTGTACGACCTGGAGCTGGACCCCACGGCCCTGGAGGAGGAGGAGAAGCAGAGCC
TCCTGGTGAAGGAGCTCCAGAGCCTGGCAGTGGCACAGCGGGACCACATGCTTCGCGGGATGCCCTTAAGCCTGGCTGAGAAACGCAGCC
TGCGAGAGAAGAGCAGGACCCCGAGGGGGAAGTGGAGGGGCCAGCCGGGCAGCGGCGGGGTCTGCTCCTGCTGTGGCCGGCTCAGATATG
CCTGCGTGCTGGCCTTGCACAGCCTGGGCCTGGCGCTGCTCTCCGCCCTGCAGGCCCTGATGCCGTGGCGCTACGCCCTGAAGCGCATCG
GGGGCCAGTTCGGCTCCAGCGTGCTCTCCTACTTCCTCTTTCTCAAGACCCTGCTGGCTTTCAATGCCCTCCTGCTGCTGCTGCTGGTGG
CCTTCATCATGGGCCCTCAGGTCGCCTTCCCACCCGCCCTGCCGGGCCCTGCCCCCGTCTGCACAGGCCTGGAGCTCCTCACAGGCGCGG
GTTGCTTCACCCACACCGTCATGTACTACGGCCACTACAGTAACGCCACGCTGAACCAGCCGTGTGGCAGCCCCCTGGATGGCAGCCAGT
GCACACCCAGGGTGGGTGGCCTGCCCTACAACATGCCCCTGGCCTACCTCTCCACTGTGGGCGTGAGCTTCTTTATCACCTGCATCACCC
TGGTGTACAGCATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGCAGCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGG
ACTACAAGGTGACGCAGAAGCGGGCCTCCCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGATTTGGAGATTGAAAATGAAGATT
TGAAAGAGAGGTTGAGAAAAATTCAGCAAGAACAAAGAATACTTTTGGATAAAGTCAATGGTTTACAGTTACAGCTGAATGAGGAAGTTA
TGGTTGCTGATGATCTGGAAAGCGAGAGAGAAAAGCTGAAGTCCCTTTTGGCAGCTAAAGAAAAGCAACATGAAGAAAGCTTAAGGACTA
TTGAGGCTCTGAAAAATAGATTTAAATATTTTGAGAGTGATCATTTAGGATCAGGAAGTCATTTCAGTAACCGAAAAGAAGATATGCTTC
TTAAACAAGGTCAGATGTATATGGCAGACTCACAGTGTACTTCCCCAGGTATACCAGCCCATATGCAAAGCAGATCTATGTTAAGACCTC
TGGAACTATCTTTACCCAGTCAAACGTCATACTCTGAAAATGAAATTTTAAAGAAAGAGTTAGAAGCAATGCGAACTTTCTGTGAGTCAG
CAAAACAAGACCGACTGAAGCTCCAAAATGAACTGGCACACAAAGTGGCAGAATGCAAAGCTTTAGCATTAGAATGTGAAAGGGTCAAGG
AGGATTCAGATGAACAGATAAAGCAATTAGAAGATGCATTAAAAGATGTGCAGAAGAGGATGTATGAGTCAGAAGGTAAAGTTAAACAAA
TGCAGACCCATTTTCTTGCCCTTAAAGAACACTTAACAAGTGAAGCAGCCTCAGGGAATCACAGACTAACCGAGGAACTGAAGGATCAGT
TGAAAGACTTGAAAGTAAAATATGAAGGTGCTTCAGCAGAAGTGGGGAAATTAAGAAACCAAATCAAACAAAATGAGATGATAGTAGAAG
AGTTTAAGAGGGATGAAGGCAAGCTGATAGAAGAAAATAAGCGATTACAGAAGGAACTTAGTATGTGTGAAATGGAGCGAGAGAAGAAAG
GAAGAAAGGTCACAGAGATGGAAGGCCAGGCAAAAGAATTGTCAGCGAAGTTGGCCCTTTCCATTCCAGCTGAAAAATTTGAAAACATGA
AGAGCTCATTATCAAATGAAGTGAATGAGAAAGCAAAAAAATTAGTAGAAATGGAAAGAGAACATGAAAAATCACTTAGTGAAATTAGAC
AGTTAAAGAGAGAACTTGAGAATGTTAAGGCCAAGCTTGCTCAGCACGTCAAACCAGAGGAACATGAACAGGTTAAGAGCAGATTAGAAC
AGAAATCAGGAGAACTTGGGAAGAAGATCACTGAGTTAACATTGAAAAATCAGACACTACAAAAGGAAATTGAAAAAGTTTATTTGGATA
ATAAGCTCCTCAAGGAGCAAGCACATAACTTAACAATTGAAATGAAAAATCATTATGTTCCTTTAAAAGTAAGTGAAGACATGAAAAAGT
CACATGATGCAATTATTGATGATCTTAATAGAAAGCTTTTAGATGTAACACAAAAATATACAGAAAAGAAGTTGGAAATGGAGAAATTGC
TACTGGAAAATGACAGCTTAAGTAAGGATGTAAGCCGCCTAGAAACTGTGTTTGTACCTCCTGAGAAACATGAAAAAGAGATAATAGCTC
TGAAATCCAATATTGTTGAACTTAAGAAACAGCTGTCTGAACTTAAGAAAAAATGTGGTGAAGACCAGGAGAAAATACACGCTCTCACAT
CTGAAAACACTAACTTGAAGAAGATGATGAGTAATCAGTATGTGCCAGTTAAAACCCATGAAGAGGTTAAAATGACACTGAATGACACGT
TAGCCAAAACTAACAGAGAATTATTAGATGTGAAGAAAAAATTTGAAGATATAAATCAGGAATTTGTAAAAATAAAAGATAAGAATGAAA
TATTAAAAAGAAACCTGGAAAACACTCAGAACCAAATAAAAGCTGAGTACATCAGCCTGGCAGAGCACGAGGCAAAGATGAGCTCGCTAA
GTCAGAGCATGAGAAAGGTGCAGGATAGTAATGCTGAAATCTTGGCCAACTACAGAAAAGGCCAAGAAGAGATTGTGACACTGCATGCCG
AAATTAAAGCCCAGAAGAAGGAGCTCGACACAATACAAGAATGCATTAAGGTAAAATACGCCCCAATTGTCAGCTTTGAGGAGTGCGAGA
GAAAATTTAAAGCAACAGAGAAAGAACTAAAAGACCAGTTATCAGAGCAGACACAAAAGTATAGTGTCAGTGAAGAAGAAGTCAAGAAAA
ACAAGCAAGAGAATGACAAGTTAAAGAAGGAGATTTTTACCCTTCAGAAAGATTTGAGAGATAAGACAGTTCTCATTGAGAAGTCTCATG
AAATGGAAAGAGCATTAAGCAGAAAAACAGACGAGCTAAACAAACAGTTAAAAGACTTGTCACAGAAATACACGGAAGTAAAGAATGTGA
AAGAGAAGCTAGTAGAAGAAAATGCCAAACAGACTTCTGAGATACTTGCAGTGCAAAATCTTTTGCAAAAACAACATGTTCCATTGGAAC
AGGTTGAGGCTCTGAAAAAATCTCTTAATGGCACAATTGAAAATCTAAAGGAAGAACTGAAGAGTATGCAAAGGTGTTACGAGAAAGAGC
AGCAGACAGTGACCAAACTGCATCAATTGTTGGAGAATCAAAAGAACTCTTCTGTACCCCTGGCAGAGCATTTGCAGATTAAAGAAGCAT
TTGAGAAAGAAGTTGGAATCATAAAAGCCAGCTTGAGAGAAAAGGAAGAAGAAAGCCAAAACAAAATGGAAGAAGTCTCCAAACTTCAGT
CGGAGGTTCAGAATACTAAACAAGCATTAAAAAAATTAGAGACTAGAGAGGTAGTTGACTTGTCTAAATATAAAGCAACAAAAAGTGATT
TGGAGACACAGATTTCTAGCTTAAATGAAAAATTGGCCAATCTGAATAGAAAGTATGAGGAAGTATGTGAGGAAGTTTTGCATGCCAAAA
AGAAGGAAATATCTGCAAAAGATGAGAAGGAATTACTGCATTTCAGCATTGAGCAAGAAATTAAGGATCAGAAGGAACGATGTGATAAGT
CCTTAACAACAATCACAGAGTTACAAAGAAGAATACAAGAATCTGCTAAACAAATAGAAGCAAAAGATAATAAGATAACTGAACTGCTTA
ATGATGTGGAAAGATTAAAACAGGCACTCAATGGCCTTTCCCAACTCACCTACACAAGTGGGAACCCCACCAAGAGGCAGAGCCAGCTGA
TTGACACTCTGCAGCACCAAGTGAAATCTCTGGAGCAACAGCTGGCCGATGCTGACAGACAGCACCAAGAAGTAATTGCAATTTATCGGA
CACACCTTCTTAGTGCTGCACAGGGTCACATGGATGAAGATGTTCAGGAGGCTCTGCTCCAGATCATACAAATGCGGCAGGGGCTTGTGT

>91358_91358_3_TMC6-UACA_TMC6_chr17_76118686_ENST00000392467_UACA_chr15_70970545_ENST00000539319_length(amino acids)=1532AA_BP=412
MARDMAQPLAFILDVPETPGDQGQGPSPYDESEVHDSFQQLIQEQSQCTAQEGLELQQREREVTGSSQQTLWRPEGTQSTATLRILASMP
SRTIGRSRGAIISQYYNRTVQLRCRSSRPLLGNFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPLSLAEKR
SLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLL
VAFIMGPQVAFPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFFITCI
TLVYSMAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEE
VMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLR
PLELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVK
QMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREK
KGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRL
EQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEK
LLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLND
TLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLH
AEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKS
HEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEK
EQQTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKS
DLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITEL
LNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGL

--------------------------------------------------------------
>91358_91358_4_TMC6-UACA_TMC6_chr17_76118686_ENST00000392467_UACA_chr15_70970545_ENST00000560441_length(transcript)=4893nt_BP=1415nt
GCGGGACTGTCTGGGCTGTGAGTGGCACCTCCTGTGGTTCCCCCAGGAATGGGTGGTGTGGACAGCTGCCAGGCGTTGAAGACCACCCCT
GGCTCTGTGCCCCTGTCTCATCAGATGGGGGCTCCGGAGGTGGCGCCCAGGCTCTGAGCTACCCTAGGTCTGCAGACTAGCGGGCATTGG
CCAGAGACATGGCCCAGCCACTGGCCTTCATCCTCGATGTCCCTGAGACCCCAGGGGACCAGGGCCAGGGCCCCAGCCCCTATGATGAAA
GCGAAGTGCACGACTCCTTCCAGCAGCTCATCCAGGAGCAGAGCCAGTGCACGGCCCAGGAGGGGCTGGAGCTGCAGCAGAGAGAGCGGG
AGGTGACAGGAAGTAGCCAGCAGACACTCTGGCGGCCCGAGGGCACCCAGAGCACGGCCACACTCCGCATCCTGGCCAGCATGCCCAGCC
GCACCATTGGCCGCAGCCGAGGTGCCATCATCTCCCAGTACTACAACCGCACGGTGCAGCTTCGGTGCAGGAGCAGCCGGCCCCTGCTCG
GGAACTTTGTCCGCTCCGCCTGGCCCAGCCTCCGCCTGTACGACCTGGAGCTGGACCCCACGGCCCTGGAGGAGGAGGAGAAGCAGAGCC
TCCTGGTGAAGGAGCTCCAGAGCCTGGCAGTGGCACAGCGGGACCACATGCTTCGCGGGATGCCCTTAAGCCTGGCTGAGAAACGCAGCC
TGCGAGAGAAGAGCAGGACCCCGAGGGGGAAGTGGAGGGGCCAGCCGGGCAGCGGCGGGGTCTGCTCCTGCTGTGGCCGGCTCAGATATG
CCTGCGTGCTGGCCTTGCACAGCCTGGGCCTGGCGCTGCTCTCCGCCCTGCAGGCCCTGATGCCGTGGCGCTACGCCCTGAAGCGCATCG
GGGGCCAGTTCGGCTCCAGCGTGCTCTCCTACTTCCTCTTTCTCAAGACCCTGCTGGCTTTCAATGCCCTCCTGCTGCTGCTGCTGGTGG
CCTTCATCATGGGCCCTCAGGTCGCCTTCCCACCCGCCCTGCCGGGCCCTGCCCCCGTCTGCACAGGCCTGGAGCTCCTCACAGGCGCGG
GTTGCTTCACCCACACCGTCATGTACTACGGCCACTACAGTAACGCCACGCTGAACCAGCCGTGTGGCAGCCCCCTGGATGGCAGCCAGT
GCACACCCAGGGTGGGTGGCCTGCCCTACAACATGCCCCTGGCCTACCTCTCCACTGTGGGCGTGAGCTTCTTTATCACCTGCATCACCC
TGGTGTACAGCATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGCAGCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGG
ACTACAAGGTGACGCAGAAGCGGGCCTCCCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGATTTGGAGATTGAAAATGAAGATT
TGAAAGAGAGGTTGAGAAAAATTCAGCAAGAACAAAGAATACTTTTGGATAAAGTCAATGGTTTACAGTTACAGCTGAATGAGGAAGTTA
TGGTTGCTGATGATCTGGAAAGCGAGAGAGAAAAGCTGAAGTCCCTTTTGGCAGCTAAAGAAAAGCAACATGAAGAAAGCTTAAGGACTA
TTGAGGCTCTGAAAAATAGATTTAAATATTTTGAGAGTGATCATTTAGGATCAGGAAGTCATTTCAGAAAAGAAGATATGCTTCTTAAAC
AAGGTCAGATGTATATGGCAGACTCACAGTGTACTTCCCCAGGTATACCAGCCCATATGCAAAGCAGATCTATGTTAAGACCTCTGGAAC
TATCTTTACCCAGTCAAACGTCATACTCTGAAAATGAAATTTTAAAGAAAGAGTTAGAAGCAATGCGAACTTTCTGTGAGTCAGCAAAAC
AAGACCGACTGAAGCTCCAAAATGAACTGGCACACAAAGTGGCAGAATGCAAAGCTTTAGCATTAGAATGTGAAAGGGTCAAGGAGGATT
CAGATGAACAGATAAAGCAATTAGAAGATGCATTAAAAGATGTGCAGAAGAGGATGTATGAGTCAGAAGGTAAAGTTAAACAAATGCAGA
CCCATTTTCTTGCCCTTAAAGAACACTTAACAAGTGAAGCAGCCTCAGGGAATCACAGACTAACCGAGGAACTGAAGGATCAGTTGAAAG
ACTTGAAAGTAAAATATGAAGGTGCTTCAGCAGAAGTGGGGAAATTAAGAAACCAAATCAAACAAAATGAGATGATAGTAGAAGAGTTTA
AGAGGGATGAAGGCAAGCTGATAGAAGAAAATAAGCGATTACAGAAGGAACTTAGTATGTGTGAAATGGAGCGAGAGAAGAAAGGAAGAA
AGGTCACAGAGATGGAAGGCCAGGCAAAAGAATTGTCAGCGAAGTTGGCCCTTTCCATTCCAGCTGAAAAATTTGAAAACATGAAGAGCT
CATTATCAAATGAAGTGAATGAGAAAGCAAAAAAATTAGTAGAAATGGAAAGAGAACATGAAAAATCACTTAGTGAAATTAGACAGTTAA
AGAGAGAACTTGAGAATGTTAAGGCCAAGCTTGCTCAGCACGTCAAACCAGAGGAACATGAACAGGTTAAGAGCAGATTAGAACAGAAAT
CAGGAGAACTTGGGAAGAAGATCACTGAGTTAACATTGAAAAATCAGACACTACAAAAGGAAATTGAAAAAGTTTATTTGGATAATAAGC
TCCTCAAGGAGCAAGCACATAACTTAACAATTGAAATGAAAAATCATTATGTTCCTTTAAAAGTAAGTGAAGACATGAAAAAGTCACATG
ATGCAATTATTGATGATCTTAATAGAAAGCTTTTAGATGTAACACAAAAATATACAGAAAAGAAGTTGGAAATGGAGAAATTGCTACTGG
AAAATGACAGCTTAAGTAAGGATGTAAGCCGCCTAGAAACTGTGTTTGTACCTCCTGAGAAACATGAAAAAGAGATAATAGCTCTGAAAT
CCAATATTGTTGAACTTAAGAAACAGCTGTCTGAACTTAAGAAAAAATGTGGTGAAGACCAGGAGAAAATACACGCTCTCACATCTGAAA
ACACTAACTTGAAGAAGATGATGAGTAATCAGTATGTGCCAGTTAAAACCCATGAAGAGGTTAAAATGACACTGAATGACACGTTAGCCA
AAACTAACAGAGAATTATTAGATGTGAAGAAAAAATTTGAAGATATAAATCAGGAATTTGTAAAAATAAAAGATAAGAATGAAATATTAA
AAAGAAACCTGGAAAACACTCAGAACCAAATAAAAGCTGAGTACATCAGCCTGGCAGAGCACGAGGCAAAGATGAGCTCGCTAAGTCAGA
GCATGAGAAAGGTGCAGGATAGTAATGCTGAAATCTTGGCCAACTACAGAAAAGGCCAAGAAGAGATTGTGACACTGCATGCCGAAATTA
AAGCCCAGAAGAAGGAGCTCGACACAATACAAGAATGCATTAAGGTAAAATACGCCCCAATTGTCAGCTTTGAGGAGTGCGAGAGAAAAT
TTAAAGCAACAGAGAAAGAACTAAAAGACCAGTTATCAGAGCAGACACAAAAGTATAGTGTCAGTGAAGAAGAAGTCAAGAAAAACAAGC
AAGAGAATGACAAGTTAAAGAAGGAGATTTTTACCCTTCAGAAAGATTTGAGAGATAAGACAGTTCTCATTGAGAAGTCTCATGAAATGG
AAAGAGCATTAAGCAGAAAAACAGACGAGCTAAACAAACAGTTAAAAGACTTGTCACAGAAATACACGGAAGTAAAGAATGTGAAAGAGA
AGCTAGTAGAAGAAAATGCCAAACAGACTTCTGAGATACTTGCAGTGCAAAATCTTTTGCAAAAACAACATGTTCCATTGGAACAGGTTG
AGGCTCTGAAAAAATCTCTTAATGGCACAATTGAAAATCTAAAGGAAGAACTGAAGAGTATGCAAAGGTGTTACGAGAAAGAGCAGCAGA
CAGTGACCAAACTGCATCAATTGTTGGAGAATCAAAAGAACTCTTCTGTACCCCTGGCAGAGCATTTGCAGATTAAAGAAGCATTTGAGA
AAGAAGTTGGAATCATAAAAGCCAGCTTGAGAGAAAAGGAAGAAGAAAGCCAAAACAAAATGGAAGAAGTCTCCAAACTTCAGTCGGAGG
TTCAGAATACTAAACAAGCATTAAAAAAATTAGAGACTAGAGAGGTAGTTGACTTGTCTAAATATAAAGCAACAAAAAGTGATTTGGAGA
CACAGATTTCTAGCTTAAATGAAAAATTGGCCAATCTGAATAGAAAGTATGAGGAAGTATGTGAGGAAGTTTTGCATGCCAAAAAGAAGG
AAATATCTGCAAAAGATGAGAAGGAATTACTGCATTTCAGCATTGAGCAAGAAATTAAGGATCAGAAGGAACGATGTGATAAGTCCTTAA
CAACAATCACAGAGTTACAAAGAAGAATACAAGAATCTGCTAAACAAATAGAAGCAAAAGATAATAAGATAACTGAACTGCTTAATGATG
TGGAAAGATTAAAACAGGCACTCAATGGCCTTTCCCAACTCACCTACACAAGTGGGAACCCCACCAAGAGGCAGAGCCAGCTGATTGACA
CTCTGCAGCACCAAGTGAAATCTCTGGAGCAACAGCTGGCCGATGCTGACAGACAGCACCAAGAAGTAATTGCAATTTATCGGACACACC
TTCTTAGTGCTGCACAGGGTCACATGGATGAAGATGTTCAGGAGGCTCTGCTCCAGATCATACAAATGCGGCAGGGGCTTGTGTGCTAGC
CGTTAGCACTGACTGCCAGTATCTGTTTTATCTTGCTGGTGCTGAACATTCTTTGTGCAACTCCATGGTCTTTCTGGGCCTTACTGTGCT

>91358_91358_4_TMC6-UACA_TMC6_chr17_76118686_ENST00000392467_UACA_chr15_70970545_ENST00000560441_length(amino acids)=1530AA_BP=412
MARDMAQPLAFILDVPETPGDQGQGPSPYDESEVHDSFQQLIQEQSQCTAQEGLELQQREREVTGSSQQTLWRPEGTQSTATLRILASMP
SRTIGRSRGAIISQYYNRTVQLRCRSSRPLLGNFVRSAWPSLRLYDLELDPTALEEEEKQSLLVKELQSLAVAQRDHMLRGMPLSLAEKR
SLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALLSALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLL
VAFIMGPQVAFPPALPGPAPVCTGLELLTGAGCFTHTVMYYGHYSNATLNQPCGSPLDGSQCTPRVGGLPYNMPLAYLSTVGVSFFITCI
TLVYSMAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEE
VMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPL
ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQM
QTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKG
RKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQ
KSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLL
LENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTL
AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAE
IKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHE
MERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQ
QTVTKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDL
ETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN
DVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLADADRQHQEVIAIYRTHLLSAAQGHMDEDVQEALLQIIQMRQGLVC

--------------------------------------------------------------
>91358_91358_5_TMC6-UACA_TMC6_chr17_76118686_ENST00000591436_UACA_chr15_70970545_ENST00000322954_length(transcript)=6006nt_BP=144nt
ATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGCAGCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGGACTACAAGGTG
ACGCAGAAGCGGGCCTCCCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGATTTGGAGATTGAAAATGAAGATTTGAAAGAGAGG
TTGAGAAAAATTCAGCAAGAACAAAGAATACTTTTGGATAAAGTCAATGGTTTACAGTTACAGCTGAATGAGGAAGTTATGGTTGCTGAT
GATCTGGAAAGCGAGAGAGAAAAGCTGAAGTCCCTTTTGGCAGCTAAAGAAAAGCAACATGAAGAAAGCTTAAGGACTATTGAGGCTCTG
AAAAATAGATTTAAATATTTTGAGAGTGATCATTTAGGATCAGGAAGTCATTTCAGTAACCGAAAAGAAGATATGCTTCTTAAACAAGGT
CAGATGTATATGGCAGACTCACAGTGTACTTCCCCAGGTATACCAGCCCATATGCAAAGCAGATCTATGTTAAGACCTCTGGAACTATCT
TTACCCAGTCAAACGTCATACTCTGAAAATGAAATTTTAAAGAAAGAGTTAGAAGCAATGCGAACTTTCTGTGAGTCAGCAAAACAAGAC
CGACTGAAGCTCCAAAATGAACTGGCACACAAAGTGGCAGAATGCAAAGCTTTAGCATTAGAATGTGAAAGGGTCAAGGAGGATTCAGAT
GAACAGATAAAGCAATTAGAAGATGCATTAAAAGATGTGCAGAAGAGGATGTATGAGTCAGAAGGTAAAGTTAAACAAATGCAGACCCAT
TTTCTTGCCCTTAAAGAACACTTAACAAGTGAAGCAGCCTCAGGGAATCACAGACTAACCGAGGAACTGAAGGATCAGTTGAAAGACTTG
AAAGTAAAATATGAAGGTGCTTCAGCAGAAGTGGGGAAATTAAGAAACCAAATCAAACAAAATGAGATGATAGTAGAAGAGTTTAAGAGG
GATGAAGGCAAGCTGATAGAAGAAAATAAGCGATTACAGAAGGAACTTAGTATGTGTGAAATGGAGCGAGAGAAGAAAGGAAGAAAGGTC
ACAGAGATGGAAGGCCAGGCAAAAGAATTGTCAGCGAAGTTGGCCCTTTCCATTCCAGCTGAAAAATTTGAAAACATGAAGAGCTCATTA
TCAAATGAAGTGAATGAGAAAGCAAAAAAATTAGTAGAAATGGAAAGAGAACATGAAAAATCACTTAGTGAAATTAGACAGTTAAAGAGA
GAACTTGAGAATGTTAAGGCCAAGCTTGCTCAGCACGTCAAACCAGAGGAACATGAACAGGTTAAGAGCAGATTAGAACAGAAATCAGGA
GAACTTGGGAAGAAGATCACTGAGTTAACATTGAAAAATCAGACACTACAAAAGGAAATTGAAAAAGTTTATTTGGATAATAAGCTCCTC
AAGGAGCAAGCACATAACTTAACAATTGAAATGAAAAATCATTATGTTCCTTTAAAAGTAAGTGAAGACATGAAAAAGTCACATGATGCA
ATTATTGATGATCTTAATAGAAAGCTTTTAGATGTAACACAAAAATATACAGAAAAGAAGTTGGAAATGGAGAAATTGCTACTGGAAAAT
GACAGCTTAAGTAAGGATGTAAGCCGCCTAGAAACTGTGTTTGTACCTCCTGAGAAACATGAAAAAGAGATAATAGCTCTGAAATCCAAT
ATTGTTGAACTTAAGAAACAGCTGTCTGAACTTAAGAAAAAATGTGGTGAAGACCAGGAGAAAATACACGCTCTCACATCTGAAAACACT
AACTTGAAGAAGATGATGAGTAATCAGTATGTGCCAGTTAAAACCCATGAAGAGGTTAAAATGACACTGAATGACACGTTAGCCAAAACT
AACAGAGAATTATTAGATGTGAAGAAAAAATTTGAAGATATAAATCAGGAATTTGTAAAAATAAAAGATAAGAATGAAATATTAAAAAGA
AACCTGGAAAACACTCAGAACCAAATAAAAGCTGAGTACATCAGCCTGGCAGAGCACGAGGCAAAGATGAGCTCGCTAAGTCAGAGCATG
AGAAAGGTGCAGGATAGTAATGCTGAAATCTTGGCCAACTACAGAAAAGGCCAAGAAGAGATTGTGACACTGCATGCCGAAATTAAAGCC
CAGAAGAAGGAGCTCGACACAATACAAGAATGCATTAAGGTAAAATACGCCCCAATTGTCAGCTTTGAGGAGTGCGAGAGAAAATTTAAA
GCAACAGAGAAAGAACTAAAAGACCAGTTATCAGAGCAGACACAAAAGTATAGTGTCAGTGAAGAAGAAGTCAAGAAAAACAAGCAAGAG
AATGACAAGTTAAAGAAGGAGATTTTTACCCTTCAGAAAGATTTGAGAGATAAGACAGTTCTCATTGAGAAGTCTCATGAAATGGAAAGA
GCATTAAGCAGAAAAACAGACGAGCTAAACAAACAGTTAAAAGACTTGTCACAGAAATACACGGAAGTAAAGAATGTGAAAGAGAAGCTA
GTAGAAGAAAATGCCAAACAGACTTCTGAGATACTTGCAGTGCAAAATCTTTTGCAAAAACAACATGTTCCATTGGAACAGGTTGAGGCT
CTGAAAAAATCTCTTAATGGCACAATTGAAAATCTAAAGGAAGAACTGAAGAGTATGCAAAGGTGTTACGAGAAAGAGCAGCAGACAGTG
ACCAAACTGCATCAATTGTTGGAGAATCAAAAGAACTCTTCTGTACCCCTGGCAGAGCATTTGCAGATTAAAGAAGCATTTGAGAAAGAA
GTTGGAATCATAAAAGCCAGCTTGAGAGAAAAGGAAGAAGAAAGCCAAAACAAAATGGAAGAAGTCTCCAAACTTCAGTCGGAGGTTCAG
AATACTAAACAAGCATTAAAAAAATTAGAGACTAGAGAGGTAGTTGACTTGTCTAAATATAAAGCAACAAAAAGTGATTTGGAGACACAG
ATTTCTAGCTTAAATGAAAAATTGGCCAATCTGAATAGAAAGTATGAGGAAGTATGTGAGGAAGTTTTGCATGCCAAAAAGAAGGAAATA
TCTGCAAAAGATGAGAAGGAATTACTGCATTTCAGCATTGAGCAAGAAATTAAGGATCAGAAGGAACGATGTGATAAGTCCTTAACAACA
ATCACAGAGTTACAAAGAAGAATACAAGAATCTGCTAAACAAATAGAAGCAAAAGATAATAAGATAACTGAACTGCTTAATGATGTGGAA
AGATTAAAACAGGCACTCAATGGCCTTTCCCAACTCACCTACACAAGTGGGAACCCCACCAAGAGGCAGAGCCAGCTGATTGACACTCTG
CAGCACCAAGTGAAATCTCTGGAGCAACAGCTGGCCGATGCTGACAGACAGCACCAAGAAGTAATTGCAATTTATCGGACACACCTTCTT
AGTGCTGCACAGGGTCACATGGATGAAGATGTTCAGGAGGCTCTGCTCCAGATCATACAAATGCGGCAGGGGCTTGTGTGCTAGCCGTTA
GCACTGACTGCCAGTATCTGTTTTATCTTGCTGGTGCTGAACATTCTTTGTGCAACTCCATGGTCTTTCTGGGCCTTACTGTGCTGGTAT
AATTAAAATAAAATATATTTTGTTCTATTGGTAGGTTTTTTTTTAAAATTAGATGAATATGTTAGTCTTTTTCAATATCAGTTTGAATCT
TATTTTCTGTATGTGTTAATTTTACAAATAGGCAAACAACATAACTTTGCCCTGGATTGACTACATATTTTTAAACCTTCAAGTCCCTAA
TAAAACATGAGCCATCTGAGTGAGTCCATATGAAGCGAGGTTAGGCTGAAATAATTGCTTAAAGATGTCTTTCAGAGAAATTAATTTGGT
TGGTGGCCACTTTTAGGTGGATCAAAAGACCTTTCAGATCCTCAGAACCTTGAGACATAATACAGTTGTGAGGAATGTGTTGTAACTTGG
CTGGCCAAGTTACATGTTACAGTATCTTTACTGAGGTAACTTCATTAGTGTCTTTGGCCTTTTTTGTAGGTATAGATATTTTTTCTTTTT
ACACTAATAACTTTTATGCCTTTTAAAATAAATTTATTTTCATAAATGGTTTGCAGTGCTAAATTACATTTAGATTAAGAACAGGCAGGG
GTGGAATATATCAGGAATTTATAATAAAATTGCCTTAATCTCTACAACAGTATCTTAATTTTTACTTGCGGTGACTATTCTTGCCACAAT
ATTGGAGAATAATGATAGATGATATACTAGATTTTTCAAAGTGTGAAAACCTTTAGACTTTTTTTAGCAATTAGTTTGACATTCGCTACT
ATAGTAACCAAGCACTCATTATATATGCATCCTCCAAATGTTTCATGCTTATTTATAGGAAAGTTATATTAATGAGATTAATAATGTGAA
ATACAGTTTTCCTGCAAAATTAGCATTAGAGAATTGATTTTAGATAACAGATTTTTAAAGTTTTAGAGAAAAGTACAGTAATACAGTAAA
CTGAAAGAGTATATAGATAGCAATAAAATAACATAAGTGGACATGTTTATAGTAAATACTCTGAAGTAAACAACCGTTTTTATTAACTGC
ATCTCATTAGGGAAAGTTTATATGTCTTGTTATTTTTTATTAACATTTTATTTACCATTCAGAGTGAAAATTACTAATTTGAGTATTAAC
AAATAACTGAATAAATGGATCATTACAGTTAGGTTTTCTCAAATTGCAAAATTTGCCTTAGCAATTATCTTTGAACATCCCGAACCAGAT
TTTTAAATCCCATTTTTGTTTAATAGGGTAAAAATACCATCAAAATGACTTCTCATACCAAAGAATAAGCCATCATATTTTTTCGGTGTT
GAAACAACATTGAAAGTCAGAATTGGATTTGTTTTTAATTCTTTATACGGTTTACATAAGCAATATCTGTCTCTTTAATTATTATGATTA
ATGTCGTCCTTCAGCATGAGTTCTGTTTCACAAGTTTTGGGCCACCTATTTCAATAAAAAATAAAATATAAATTAAAAAAGTTGCCGGGG
GTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGGAGGTAGATCACCTGAGGTCAGAAGTTCGAGACCAGCCTTACCAAT
ATGGTGAAGCCCCATCTCTACTAAAAATACAAAAATTAGCCCTGCATGGTGGCAGGTGCCTGTAGTCCCAGGTACTCGGGAGGCTGAGAC
AGGAGAATCGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCAAGATCTCGCCACTGCACTCCAGCTTGGGCAATAGCAAGACTCCATC
TCAAAATAAAATAAAATAAAACTTAGAGCAAAGTTTAAAACTGAGTATTCATATTAAGTGTTTTATTTTCCATATTAGAGATGGGAAGGG
AACCTTATGTGTATTTTATTTTGTTTTCAACCATCAATAAAGTTTTCTCTAGAATATTGTTTTGAACATCCTTGTAAAAGATTTGCGAGT
TAAACTATTTTATTTACTGTCTGTGAGAGCATTGGGAGTAGGAAACGATGGACTCCAAAGTACAAGGGAGAATACCCATTTTCATTCAGC
TATCTGGAGTAAAATATCAAGTACTTCCTTCAACTAATCTTGTCTCATTCACTCACCTTTTGATATCGAAGGCAGAAATTGCGTTTACAA
CACTGAAGACCAAAGCTTTTTAATTAGTAAACAAGCGGAACATAGATAATGGACAATGCTGGCCACTGCCATTCTGTGTTCAGAAAGACT
ATGAGACCTGAACATATGGCCAAGAGGAAAGAAGAGTGACGTTGTCTAAGATGTAATGAGTGCTCTCTGAGAGAATCACTCAATTCCTAT
TGGAGTGCAATCCTTACTTGAGAACTTTATTACTCTTGTTCTGTGTAGTTTTTTTTTTTTGTCACTTCCCCATCAGAAAAGCATATTCTT

>91358_91358_5_TMC6-UACA_TMC6_chr17_76118686_ENST00000591436_UACA_chr15_70970545_ENST00000322954_length(amino acids)=1167AA_BP=47
MAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVAD
DLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELS
LPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTH
FLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV
TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG
ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEN
DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT
NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKA
QKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMER
ALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTV
TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQ
ISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVE

--------------------------------------------------------------
>91358_91358_6_TMC6-UACA_TMC6_chr17_76118686_ENST00000591436_UACA_chr15_70970545_ENST00000379983_length(transcript)=3758nt_BP=144nt
ATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGCAGCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGGACTACAAGGTG
ACGCAGAAGCGGGCCTCCCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGATTTGGAGATTGAAAATGAAGATTTGAAAGAGAGG
TTGAGAAAAATTCAGCAAGAACAAAGAATACTTTTGGATAAAGTCAATGGTTTACAGTTACAGCTGAATGAGGAAGTTATGGTTGCTGAT
GATCTGGAAAGCGAGAGAGAAAAGCTGAAGTCCCTTTTGGCAGCTAAAGAAAAGCAACATGAAGAAAGCTTAAGGACTATTGAGGCTCTG
AAAAATAGATTTAAATATTTTGAGAGTGATCATTTAGGATCAGGAAGTCATTTCAGTAACCGAAAAGAAGATATGCTTCTTAAACAAGGT
CAGATGTATATGGCAGACTCACAGTGTACTTCCCCAGGTATACCAGCCCATATGCAAAGCAGATCTATGTTAAGACCTCTGGAACTATCT
TTACCCAGTCAAACGTCATACTCTGAAAATGAAATTTTAAAGAAAGAGTTAGAAGCAATGCGAACTTTCTGTGAGTCAGCAAAACAAGAC
CGACTGAAGCTCCAAAATGAACTGGCACACAAAGTGGCAGAATGCAAAGCTTTAGCATTAGAATGTGAAAGGGTCAAGGAGGATTCAGAT
GAACAGATAAAGCAATTAGAAGATGCATTAAAAGATGTGCAGAAGAGGATGTATGAGTCAGAAGGTAAAGTTAAACAAATGCAGACCCAT
TTTCTTGCCCTTAAAGAACACTTAACAAGTGAAGCAGCCTCAGGGAATCACAGACTAACCGAGGAACTGAAGGATCAGTTGAAAGACTTG
AAAGTAAAATATGAAGGTGCTTCAGCAGAAGTGGGGAAATTAAGAAACCAAATCAAACAAAATGAGATGATAGTAGAAGAGTTTAAGAGG
GATGAAGGCAAGCTGATAGAAGAAAATAAGCGATTACAGAAGGAACTTAGTATGTGTGAAATGGAGCGAGAGAAGAAAGGAAGAAAGGTC
ACAGAGATGGAAGGCCAGGCAAAAGAATTGTCAGCGAAGTTGGCCCTTTCCATTCCAGCTGAAAAATTTGAAAACATGAAGAGCTCATTA
TCAAATGAAGTGAATGAGAAAGCAAAAAAATTAGTAGAAATGGAAAGAGAACATGAAAAATCACTTAGTGAAATTAGACAGTTAAAGAGA
GAACTTGAGAATGTTAAGGCCAAGCTTGCTCAGCACGTCAAACCAGAGGAACATGAACAGGTTAAGAGCAGATTAGAACAGAAATCAGGA
GAACTTGGGAAGAAGATCACTGAGTTAACATTGAAAAATCAGACACTACAAAAGGAAATTGAAAAAGTTTATTTGGATAATAAGCTCCTC
AAGGAGCAAGCACATAACTTAACAATTGAAATGAAAAATCATTATGTTCCTTTAAAAGTAAGTGAAGACATGAAAAAGTCACATGATGCA
ATTATTGATGATCTTAATAGAAAGCTTTTAGATGTAACACAAAAATATACAGAAAAGAAGTTGGAAATGGAGAAATTGCTACTGGAAAAT
GACAGCTTAAGTAAGGATGTAAGCCGCCTAGAAACTGTGTTTGTACCTCCTGAGAAACATGAAAAAGAGATAATAGCTCTGAAATCCAAT
ATTGTTGAACTTAAGAAACAGCTGTCTGAACTTAAGAAAAAATGTGGTGAAGACCAGGAGAAAATACACGCTCTCACATCTGAAAACACT
AACTTGAAGAAGATGATGAGTAATCAGTATGTGCCAGTTAAAACCCATGAAGAGGTTAAAATGACACTGAATGACACGTTAGCCAAAACT
AACAGAGAATTATTAGATGTGAAGAAAAAATTTGAAGATATAAATCAGGAATTTGTAAAAATAAAAGATAAGAATGAAATATTAAAAAGA
AACCTGGAAAACACTCAGAACCAAATAAAAGCTGAGTACATCAGCCTGGCAGAGCACGAGGCAAAGATGAGCTCGCTAAGTCAGAGCATG
AGAAAGGTGCAGGATAGTAATGCTGAAATCTTGGCCAACTACAGAAAAGGCCAAGAAGAGATTGTGACACTGCATGCCGAAATTAAAGCC
CAGAAGAAGGAGCTCGACACAATACAAGAATGCATTAAGGTAAAATACGCCCCAATTGTCAGCTTTGAGGAGTGCGAGAGAAAATTTAAA
GCAACAGAGAAAGAACTAAAAGACCAGTTATCAGAGCAGACACAAAAGTATAGTGTCAGTGAAGAAGAAGTCAAGAAAAACAAGCAAGAG
AATGACAAGTTAAAGAAGGAGATTTTTACCCTTCAGAAAGATTTGAGAGATAAGACAGTTCTCATTGAGAAGTCTCATGAAATGGAAAGA
GCATTAAGCAGAAAAACAGACGAGCTAAACAAACAGTTAAAAGACTTGTCACAGAAATACACGGAAGTAAAGAATGTGAAAGAGAAGCTA
GTAGAAGAAAATGCCAAACAGACTTCTGAGATACTTGCAGTGCAAAATCTTTTGCAAAAACAACATGTTCCATTGGAACAGGTTGAGGCT
CTGAAAAAATCTCTTAATGGCACAATTGAAAATCTAAAGGAAGAACTGAAGAGTATGCAAAGGTGTTACGAGAAAGAGCAGCAGACAGTG
ACCAAACTGCATCAATTGTTGGAGAATCAAAAGAACTCTTCTGTACCCCTGGCAGAGCATTTGCAGATTAAAGAAGCATTTGAGAAAGAA
GTTGGAATCATAAAAGCCAGCTTGAGAGAAAAGGAAGAAGAAAGCCAAAACAAAATGGAAGAAGTCTCCAAACTTCAGTCGGAGGTTCAG
AATACTAAACAAGCATTAAAAAAATTAGAGACTAGAGAGGTAGTTGACTTGTCTAAATATAAAGCAACAAAAAGTGATTTGGAGACACAG
ATTTCTAGCTTAAATGAAAAATTGGCCAATCTGAATAGAAAGTATGAGGAAGTATGTGAGGAAGTTTTGCATGCCAAAAAGAAGGAAATA
TCTGCAAAAGATGAGAAGGAATTACTGCATTTCAGCATTGAGCAAGAAATTAAGGATCAGAAGGAACGATGTGATAAGTCCTTAACAACA
ATCACAGAGTTACAAAGAAGAATACAAGAATCTGCTAAACAAATAGAAGCAAAAGATAATAAGATAACTGAACTGCTTAATGATGTGGAA
AGATTAAAACAGGCACTCAATGGCCTTTCCCAACTCACCTACACAAGTGGGAACCCCACCAAGAGGCAGAGCCAGCTGATTGACACTCTG
CAGCACCAAGTGAAATCTCTGGAGCAACAGCTGGCCGATGCTGACAGACAGCACCAAGAAGTAATTGCAATTTATCGGACACACCTTCTT
AGTGCTGCACAGGGTCACATGGATGAAGATGTTCAGGAGGCTCTGCTCCAGATCATACAAATGCGGCAGGGGCTTGTGTGCTAGCCGTTA
GCACTGACTGCCAGTATCTGTTTTATCTTGCTGGTGCTGAACATTCTTTGTGCAACTCCATGGTCTTTCTGGGCCTTACTGTGCTGGTAT
AATTAAAATAAAATATATTTTGTTCTATTGGTAGGTTTTTTTTTAAAATTAGATGAATATGTTAGTCTTTTTCAATATCAGTTTGAATCT

>91358_91358_6_TMC6-UACA_TMC6_chr17_76118686_ENST00000591436_UACA_chr15_70970545_ENST00000379983_length(amino acids)=1167AA_BP=47
MAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVAD
DLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELS
LPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTH
FLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV
TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG
ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEN
DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT
NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKA
QKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMER
ALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTV
TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQ
ISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVE

--------------------------------------------------------------
>91358_91358_7_TMC6-UACA_TMC6_chr17_76118686_ENST00000591436_UACA_chr15_70970545_ENST00000539319_length(transcript)=3583nt_BP=144nt
ATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGCAGCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGGACTACAAGGTG
ACGCAGAAGCGGGCCTCCCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGATTTGGAGATTGAAAATGAAGATTTGAAAGAGAGG
TTGAGAAAAATTCAGCAAGAACAAAGAATACTTTTGGATAAAGTCAATGGTTTACAGTTACAGCTGAATGAGGAAGTTATGGTTGCTGAT
GATCTGGAAAGCGAGAGAGAAAAGCTGAAGTCCCTTTTGGCAGCTAAAGAAAAGCAACATGAAGAAAGCTTAAGGACTATTGAGGCTCTG
AAAAATAGATTTAAATATTTTGAGAGTGATCATTTAGGATCAGGAAGTCATTTCAGTAACCGAAAAGAAGATATGCTTCTTAAACAAGGT
CAGATGTATATGGCAGACTCACAGTGTACTTCCCCAGGTATACCAGCCCATATGCAAAGCAGATCTATGTTAAGACCTCTGGAACTATCT
TTACCCAGTCAAACGTCATACTCTGAAAATGAAATTTTAAAGAAAGAGTTAGAAGCAATGCGAACTTTCTGTGAGTCAGCAAAACAAGAC
CGACTGAAGCTCCAAAATGAACTGGCACACAAAGTGGCAGAATGCAAAGCTTTAGCATTAGAATGTGAAAGGGTCAAGGAGGATTCAGAT
GAACAGATAAAGCAATTAGAAGATGCATTAAAAGATGTGCAGAAGAGGATGTATGAGTCAGAAGGTAAAGTTAAACAAATGCAGACCCAT
TTTCTTGCCCTTAAAGAACACTTAACAAGTGAAGCAGCCTCAGGGAATCACAGACTAACCGAGGAACTGAAGGATCAGTTGAAAGACTTG
AAAGTAAAATATGAAGGTGCTTCAGCAGAAGTGGGGAAATTAAGAAACCAAATCAAACAAAATGAGATGATAGTAGAAGAGTTTAAGAGG
GATGAAGGCAAGCTGATAGAAGAAAATAAGCGATTACAGAAGGAACTTAGTATGTGTGAAATGGAGCGAGAGAAGAAAGGAAGAAAGGTC
ACAGAGATGGAAGGCCAGGCAAAAGAATTGTCAGCGAAGTTGGCCCTTTCCATTCCAGCTGAAAAATTTGAAAACATGAAGAGCTCATTA
TCAAATGAAGTGAATGAGAAAGCAAAAAAATTAGTAGAAATGGAAAGAGAACATGAAAAATCACTTAGTGAAATTAGACAGTTAAAGAGA
GAACTTGAGAATGTTAAGGCCAAGCTTGCTCAGCACGTCAAACCAGAGGAACATGAACAGGTTAAGAGCAGATTAGAACAGAAATCAGGA
GAACTTGGGAAGAAGATCACTGAGTTAACATTGAAAAATCAGACACTACAAAAGGAAATTGAAAAAGTTTATTTGGATAATAAGCTCCTC
AAGGAGCAAGCACATAACTTAACAATTGAAATGAAAAATCATTATGTTCCTTTAAAAGTAAGTGAAGACATGAAAAAGTCACATGATGCA
ATTATTGATGATCTTAATAGAAAGCTTTTAGATGTAACACAAAAATATACAGAAAAGAAGTTGGAAATGGAGAAATTGCTACTGGAAAAT
GACAGCTTAAGTAAGGATGTAAGCCGCCTAGAAACTGTGTTTGTACCTCCTGAGAAACATGAAAAAGAGATAATAGCTCTGAAATCCAAT
ATTGTTGAACTTAAGAAACAGCTGTCTGAACTTAAGAAAAAATGTGGTGAAGACCAGGAGAAAATACACGCTCTCACATCTGAAAACACT
AACTTGAAGAAGATGATGAGTAATCAGTATGTGCCAGTTAAAACCCATGAAGAGGTTAAAATGACACTGAATGACACGTTAGCCAAAACT
AACAGAGAATTATTAGATGTGAAGAAAAAATTTGAAGATATAAATCAGGAATTTGTAAAAATAAAAGATAAGAATGAAATATTAAAAAGA
AACCTGGAAAACACTCAGAACCAAATAAAAGCTGAGTACATCAGCCTGGCAGAGCACGAGGCAAAGATGAGCTCGCTAAGTCAGAGCATG
AGAAAGGTGCAGGATAGTAATGCTGAAATCTTGGCCAACTACAGAAAAGGCCAAGAAGAGATTGTGACACTGCATGCCGAAATTAAAGCC
CAGAAGAAGGAGCTCGACACAATACAAGAATGCATTAAGGTAAAATACGCCCCAATTGTCAGCTTTGAGGAGTGCGAGAGAAAATTTAAA
GCAACAGAGAAAGAACTAAAAGACCAGTTATCAGAGCAGACACAAAAGTATAGTGTCAGTGAAGAAGAAGTCAAGAAAAACAAGCAAGAG
AATGACAAGTTAAAGAAGGAGATTTTTACCCTTCAGAAAGATTTGAGAGATAAGACAGTTCTCATTGAGAAGTCTCATGAAATGGAAAGA
GCATTAAGCAGAAAAACAGACGAGCTAAACAAACAGTTAAAAGACTTGTCACAGAAATACACGGAAGTAAAGAATGTGAAAGAGAAGCTA
GTAGAAGAAAATGCCAAACAGACTTCTGAGATACTTGCAGTGCAAAATCTTTTGCAAAAACAACATGTTCCATTGGAACAGGTTGAGGCT
CTGAAAAAATCTCTTAATGGCACAATTGAAAATCTAAAGGAAGAACTGAAGAGTATGCAAAGGTGTTACGAGAAAGAGCAGCAGACAGTG
ACCAAACTGCATCAATTGTTGGAGAATCAAAAGAACTCTTCTGTACCCCTGGCAGAGCATTTGCAGATTAAAGAAGCATTTGAGAAAGAA
GTTGGAATCATAAAAGCCAGCTTGAGAGAAAAGGAAGAAGAAAGCCAAAACAAAATGGAAGAAGTCTCCAAACTTCAGTCGGAGGTTCAG
AATACTAAACAAGCATTAAAAAAATTAGAGACTAGAGAGGTAGTTGACTTGTCTAAATATAAAGCAACAAAAAGTGATTTGGAGACACAG
ATTTCTAGCTTAAATGAAAAATTGGCCAATCTGAATAGAAAGTATGAGGAAGTATGTGAGGAAGTTTTGCATGCCAAAAAGAAGGAAATA
TCTGCAAAAGATGAGAAGGAATTACTGCATTTCAGCATTGAGCAAGAAATTAAGGATCAGAAGGAACGATGTGATAAGTCCTTAACAACA
ATCACAGAGTTACAAAGAAGAATACAAGAATCTGCTAAACAAATAGAAGCAAAAGATAATAAGATAACTGAACTGCTTAATGATGTGGAA
AGATTAAAACAGGCACTCAATGGCCTTTCCCAACTCACCTACACAAGTGGGAACCCCACCAAGAGGCAGAGCCAGCTGATTGACACTCTG
CAGCACCAAGTGAAATCTCTGGAGCAACAGCTGGCCGATGCTGACAGACAGCACCAAGAAGTAATTGCAATTTATCGGACACACCTTCTT
AGTGCTGCACAGGGTCACATGGATGAAGATGTTCAGGAGGCTCTGCTCCAGATCATACAAATGCGGCAGGGGCTTGTGTGCTAGCCGTTA

>91358_91358_7_TMC6-UACA_TMC6_chr17_76118686_ENST00000591436_UACA_chr15_70970545_ENST00000539319_length(amino acids)=1167AA_BP=47
MAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVAD
DLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELS
LPSQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTH
FLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKV
TEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSG
ELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLEN
DSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKT
NRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKA
QKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMER
ALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTV
TKLHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQ
ISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVE

--------------------------------------------------------------
>91358_91358_8_TMC6-UACA_TMC6_chr17_76118686_ENST00000591436_UACA_chr15_70970545_ENST00000560441_length(transcript)=3622nt_BP=144nt
ATGGCTCACTCTTTCGGGGAGAGCTACCGGGTGGGCAGCACCTCTGGCATCCACGCCATCACCGTCTTCTGCTCCTGGGACTACAAGGTG
ACGCAGAAGCGGGCCTCCCGCCTCCAGCAGGACAATATTCGCACCCGGCTGAAGGATTTGGAGATTGAAAATGAAGATTTGAAAGAGAGG
TTGAGAAAAATTCAGCAAGAACAAAGAATACTTTTGGATAAAGTCAATGGTTTACAGTTACAGCTGAATGAGGAAGTTATGGTTGCTGAT
GATCTGGAAAGCGAGAGAGAAAAGCTGAAGTCCCTTTTGGCAGCTAAAGAAAAGCAACATGAAGAAAGCTTAAGGACTATTGAGGCTCTG
AAAAATAGATTTAAATATTTTGAGAGTGATCATTTAGGATCAGGAAGTCATTTCAGAAAAGAAGATATGCTTCTTAAACAAGGTCAGATG
TATATGGCAGACTCACAGTGTACTTCCCCAGGTATACCAGCCCATATGCAAAGCAGATCTATGTTAAGACCTCTGGAACTATCTTTACCC
AGTCAAACGTCATACTCTGAAAATGAAATTTTAAAGAAAGAGTTAGAAGCAATGCGAACTTTCTGTGAGTCAGCAAAACAAGACCGACTG
AAGCTCCAAAATGAACTGGCACACAAAGTGGCAGAATGCAAAGCTTTAGCATTAGAATGTGAAAGGGTCAAGGAGGATTCAGATGAACAG
ATAAAGCAATTAGAAGATGCATTAAAAGATGTGCAGAAGAGGATGTATGAGTCAGAAGGTAAAGTTAAACAAATGCAGACCCATTTTCTT
GCCCTTAAAGAACACTTAACAAGTGAAGCAGCCTCAGGGAATCACAGACTAACCGAGGAACTGAAGGATCAGTTGAAAGACTTGAAAGTA
AAATATGAAGGTGCTTCAGCAGAAGTGGGGAAATTAAGAAACCAAATCAAACAAAATGAGATGATAGTAGAAGAGTTTAAGAGGGATGAA
GGCAAGCTGATAGAAGAAAATAAGCGATTACAGAAGGAACTTAGTATGTGTGAAATGGAGCGAGAGAAGAAAGGAAGAAAGGTCACAGAG
ATGGAAGGCCAGGCAAAAGAATTGTCAGCGAAGTTGGCCCTTTCCATTCCAGCTGAAAAATTTGAAAACATGAAGAGCTCATTATCAAAT
GAAGTGAATGAGAAAGCAAAAAAATTAGTAGAAATGGAAAGAGAACATGAAAAATCACTTAGTGAAATTAGACAGTTAAAGAGAGAACTT
GAGAATGTTAAGGCCAAGCTTGCTCAGCACGTCAAACCAGAGGAACATGAACAGGTTAAGAGCAGATTAGAACAGAAATCAGGAGAACTT
GGGAAGAAGATCACTGAGTTAACATTGAAAAATCAGACACTACAAAAGGAAATTGAAAAAGTTTATTTGGATAATAAGCTCCTCAAGGAG
CAAGCACATAACTTAACAATTGAAATGAAAAATCATTATGTTCCTTTAAAAGTAAGTGAAGACATGAAAAAGTCACATGATGCAATTATT
GATGATCTTAATAGAAAGCTTTTAGATGTAACACAAAAATATACAGAAAAGAAGTTGGAAATGGAGAAATTGCTACTGGAAAATGACAGC
TTAAGTAAGGATGTAAGCCGCCTAGAAACTGTGTTTGTACCTCCTGAGAAACATGAAAAAGAGATAATAGCTCTGAAATCCAATATTGTT
GAACTTAAGAAACAGCTGTCTGAACTTAAGAAAAAATGTGGTGAAGACCAGGAGAAAATACACGCTCTCACATCTGAAAACACTAACTTG
AAGAAGATGATGAGTAATCAGTATGTGCCAGTTAAAACCCATGAAGAGGTTAAAATGACACTGAATGACACGTTAGCCAAAACTAACAGA
GAATTATTAGATGTGAAGAAAAAATTTGAAGATATAAATCAGGAATTTGTAAAAATAAAAGATAAGAATGAAATATTAAAAAGAAACCTG
GAAAACACTCAGAACCAAATAAAAGCTGAGTACATCAGCCTGGCAGAGCACGAGGCAAAGATGAGCTCGCTAAGTCAGAGCATGAGAAAG
GTGCAGGATAGTAATGCTGAAATCTTGGCCAACTACAGAAAAGGCCAAGAAGAGATTGTGACACTGCATGCCGAAATTAAAGCCCAGAAG
AAGGAGCTCGACACAATACAAGAATGCATTAAGGTAAAATACGCCCCAATTGTCAGCTTTGAGGAGTGCGAGAGAAAATTTAAAGCAACA
GAGAAAGAACTAAAAGACCAGTTATCAGAGCAGACACAAAAGTATAGTGTCAGTGAAGAAGAAGTCAAGAAAAACAAGCAAGAGAATGAC
AAGTTAAAGAAGGAGATTTTTACCCTTCAGAAAGATTTGAGAGATAAGACAGTTCTCATTGAGAAGTCTCATGAAATGGAAAGAGCATTA
AGCAGAAAAACAGACGAGCTAAACAAACAGTTAAAAGACTTGTCACAGAAATACACGGAAGTAAAGAATGTGAAAGAGAAGCTAGTAGAA
GAAAATGCCAAACAGACTTCTGAGATACTTGCAGTGCAAAATCTTTTGCAAAAACAACATGTTCCATTGGAACAGGTTGAGGCTCTGAAA
AAATCTCTTAATGGCACAATTGAAAATCTAAAGGAAGAACTGAAGAGTATGCAAAGGTGTTACGAGAAAGAGCAGCAGACAGTGACCAAA
CTGCATCAATTGTTGGAGAATCAAAAGAACTCTTCTGTACCCCTGGCAGAGCATTTGCAGATTAAAGAAGCATTTGAGAAAGAAGTTGGA
ATCATAAAAGCCAGCTTGAGAGAAAAGGAAGAAGAAAGCCAAAACAAAATGGAAGAAGTCTCCAAACTTCAGTCGGAGGTTCAGAATACT
AAACAAGCATTAAAAAAATTAGAGACTAGAGAGGTAGTTGACTTGTCTAAATATAAAGCAACAAAAAGTGATTTGGAGACACAGATTTCT
AGCTTAAATGAAAAATTGGCCAATCTGAATAGAAAGTATGAGGAAGTATGTGAGGAAGTTTTGCATGCCAAAAAGAAGGAAATATCTGCA
AAAGATGAGAAGGAATTACTGCATTTCAGCATTGAGCAAGAAATTAAGGATCAGAAGGAACGATGTGATAAGTCCTTAACAACAATCACA
GAGTTACAAAGAAGAATACAAGAATCTGCTAAACAAATAGAAGCAAAAGATAATAAGATAACTGAACTGCTTAATGATGTGGAAAGATTA
AAACAGGCACTCAATGGCCTTTCCCAACTCACCTACACAAGTGGGAACCCCACCAAGAGGCAGAGCCAGCTGATTGACACTCTGCAGCAC
CAAGTGAAATCTCTGGAGCAACAGCTGGCCGATGCTGACAGACAGCACCAAGAAGTAATTGCAATTTATCGGACACACCTTCTTAGTGCT
GCACAGGGTCACATGGATGAAGATGTTCAGGAGGCTCTGCTCCAGATCATACAAATGCGGCAGGGGCTTGTGTGCTAGCCGTTAGCACTG
ACTGCCAGTATCTGTTTTATCTTGCTGGTGCTGAACATTCTTTGTGCAACTCCATGGTCTTTCTGGGCCTTACTGTGCTGGTATAATTAA

>91358_91358_8_TMC6-UACA_TMC6_chr17_76118686_ENST00000591436_UACA_chr15_70970545_ENST00000560441_length(amino acids)=1165AA_BP=47
MAHSFGESYRVGSTSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVAD
DLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFRKEDMLLKQGQMYMADSQCTSPGIPAHMQSRSMLRPLELSLP
SQTSYSENEILKKELEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFL
ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEMEREKKGRKVTE
MEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGEL
GKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDS
LSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNR
ELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQK
KELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHEMERAL
SRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTK
LHQLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQIS
SLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMC6-UACA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMC6-UACA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMC6-UACA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource