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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMCO4-MAP7D1 (FusionGDB2 ID:91411)

Fusion Gene Summary for TMCO4-MAP7D1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMCO4-MAP7D1
Fusion gene ID: 91411
HgeneTgene
Gene symbol

TMCO4

MAP7D1

Gene ID

255104

55700

Gene nametransmembrane and coiled-coil domains 4MAP7 domain containing 1
Synonyms-PARCC1|RPRC1
Cytomap

1p36.13

1p34.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane and coiled-coil domain-containing protein 4MAP7 domain-containing protein 1arginine/proline rich coiled-coil 1arginine/proline-rich coiled-coil domain-containing protein 1proline arginine rich coiled coil 1proline/arginine-rich coiled-coil domain-containing protein 1
Modification date2020031320200313
UniProtAcc.

Q3KQU3

Ensembl transtripts involved in fusion geneENST00000294543, ENST00000375122, 
ENST00000375127, ENST00000489814, 
ENST00000373148, ENST00000474796, 
ENST00000316156, ENST00000373150, 
ENST00000373151, 
Fusion gene scores* DoF score7 X 6 X 5=2107 X 10 X 6=420
# samples 713
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMCO4 [Title/Abstract] AND MAP7D1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMCO4(20097035)-MAP7D1(36636572), # samples:1
Anticipated loss of major functional domain due to fusion event.TMCO4-MAP7D1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMCO4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP7D1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1XZ-01ATMCO4chr1

20097035

-MAP7D1chr1

36636572

+


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Fusion Gene ORF analysis for TMCO4-MAP7D1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000294543ENST00000373148TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
5CDS-intronENST00000294543ENST00000474796TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
5CDS-intronENST00000375122ENST00000373148TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
5CDS-intronENST00000375122ENST00000474796TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
5CDS-intronENST00000375127ENST00000373148TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
5CDS-intronENST00000375127ENST00000474796TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
Frame-shiftENST00000294543ENST00000316156TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
Frame-shiftENST00000294543ENST00000373150TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
Frame-shiftENST00000294543ENST00000373151TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
Frame-shiftENST00000375122ENST00000316156TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
Frame-shiftENST00000375122ENST00000373150TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
Frame-shiftENST00000375122ENST00000373151TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
In-frameENST00000375127ENST00000316156TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
In-frameENST00000375127ENST00000373150TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
In-frameENST00000375127ENST00000373151TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
intron-3CDSENST00000489814ENST00000316156TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
intron-3CDSENST00000489814ENST00000373150TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
intron-3CDSENST00000489814ENST00000373151TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
intron-intronENST00000489814ENST00000373148TMCO4chr1

20097035

-MAP7D1chr1

36636572

+
intron-intronENST00000489814ENST00000474796TMCO4chr1

20097035

-MAP7D1chr1

36636572

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375127TMCO4chr120097035-ENST00000316156MAP7D1chr136636572+36106532593018919
ENST00000375127TMCO4chr120097035-ENST00000373150MAP7D1chr136636572+36256532593033924
ENST00000375127TMCO4chr120097035-ENST00000373151MAP7D1chr136636572+37156532593132957

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375127ENST00000316156TMCO4chr120097035-MAP7D1chr136636572+0.0200153350.97998464
ENST00000375127ENST00000373150TMCO4chr120097035-MAP7D1chr136636572+0.0177355430.98226446
ENST00000375127ENST00000373151TMCO4chr120097035-MAP7D1chr136636572+0.0145088030.9854913

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Fusion Genomic Features for TMCO4-MAP7D1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMCO4chr120097034-MAP7D1chr136636571+0.0009250190.99907494
TMCO4chr120097034-MAP7D1chr136636571+0.0009250190.99907494

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMCO4-MAP7D1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:20097035/chr1:36636572)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP7D1

Q3KQU3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000316156016128_22215804.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000316156016412_44115804.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000316156016593_72115804.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373148010128_2220378.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373148010412_4410378.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373148010593_7210378.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373150018128_22215809.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373150018412_44115809.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373150018593_72115809.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373151017128_22215842.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373151017412_44115842.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373151017593_72115842.0Coiled coilOntology_term=ECO:0000255
TgeneMAP7D1chr1:20097035chr1:36636572ENST0000031615601614_12715804.0Compositional biasNote=Pro-rich
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000316156016467_58915804.0Compositional biasNote=Pro-rich
TgeneMAP7D1chr1:20097035chr1:36636572ENST0000037314801014_1270378.0Compositional biasNote=Pro-rich
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373148010467_5890378.0Compositional biasNote=Pro-rich
TgeneMAP7D1chr1:20097035chr1:36636572ENST0000037315001814_12715809.0Compositional biasNote=Pro-rich
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373150018467_58915809.0Compositional biasNote=Pro-rich
TgeneMAP7D1chr1:20097035chr1:36636572ENST0000037315101714_12715842.0Compositional biasNote=Pro-rich
TgeneMAP7D1chr1:20097035chr1:36636572ENST00000373151017467_58915842.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMCO4chr1:20097035chr1:36636572ENST00000294543-616150_190127635.0Coiled coilOntology_term=ECO:0000255
HgeneTMCO4chr1:20097035chr1:36636572ENST00000375122-615150_190127595.0Coiled coilOntology_term=ECO:0000255
HgeneTMCO4chr1:20097035chr1:36636572ENST00000294543-616203_223127635.0TransmembraneHelical
HgeneTMCO4chr1:20097035chr1:36636572ENST00000294543-616231_251127635.0TransmembraneHelical
HgeneTMCO4chr1:20097035chr1:36636572ENST00000294543-616346_366127635.0TransmembraneHelical
HgeneTMCO4chr1:20097035chr1:36636572ENST00000375122-615203_223127595.0TransmembraneHelical
HgeneTMCO4chr1:20097035chr1:36636572ENST00000375122-615231_251127595.0TransmembraneHelical
HgeneTMCO4chr1:20097035chr1:36636572ENST00000375122-615346_366127595.0TransmembraneHelical


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Fusion Gene Sequence for TMCO4-MAP7D1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91411_91411_1_TMCO4-MAP7D1_TMCO4_chr1_20097035_ENST00000375127_MAP7D1_chr1_36636572_ENST00000316156_length(transcript)=3610nt_BP=653nt
CAAACAGAGAATTCCAGGAGGGCTTGGGGAGCCTCTGGAGAAAAACCAGGCTCCTCATGTTACAAGGAGGCCATGTCTTCTGGTGCCCAT
GCCTGAAGTTACAGGAGGGAAGAATTACTGCTGCTGACTTTTGAGTGGATTTTACAGCTGGGTAAACTGAGGCTCAGAGAGGGCAATTTG
CATATTTCTCCAAAGAACCATCCAGAACCTGAGCAGCCTGTCTTCAGACAGAGAGAGGCCCACGGCTGTTTCTTGAAATCTGGCGCTGGG
AATGGCCATGTGGAACAGGCCATGCCAGAGGCTGCCTCAGCAGCCTCTGGTAGCTGAGCCCACTGCAGAGGGGGAGCCACACCTGCCCAC
GGGCCGGGAGCTGACTGAGGCCAACCGCTTCGCCTATGCTGCCCTCTGTGGCATCTCCCTGTCCCAGTTATTTCCTGAACCCGAACACAG
CTCCTTCTGCACAGAGTTCATGGCAGGCCTGGTGCAGTGGCTGGAGTTGTCTGAAGCTGTCTTGCCAACCATGACTGCTTTTGCGAGCGG
CCTGGGAGGTGAAGGAGCAGATGTGTTTGTTCAAATTTTACTGAAGGACCCCATCTTGAAGGACGACCCGACGGTGATCACTCAGGACCT
TCTGAGCTTCTCACTCAAGGATGCTGTGGTCGCCAGGACCCCCCCAGAGCCAAGACCTTCTCCAGAAGGTGACCCTTCCCCCCCACCACC
ACCAATGTCAGCCCTGGTCCCCGACACTCCCCCGGACACCCCTCCTGCCATGAAGAATGCCACTAGCTCTAAGCAGCTCCCACTGGAACC
AGAGAGCCCCTCAGGGCAGGTCGGGCCTAGGCCAGCCCCCCCGCAGGAAGAGTCCCCTTCCTCTGAAGCAAAGAGCAGAGGACCCACCCC
ACCAGCCATGGGCCCACGGGATGCCAGACCTCCTCGAAGGAGCAGCCAGCCATCTCCAACAGCAGTGCCAGCCTCCGACAGCCCTCCCAC
CAAGCAAGAGGTGAAGAAGGCAGGAGAGAGACACAAGCTGGCAAAGGAGCGGCGAGAAGAGCGGGCCAAGTACCTGGCGGCCAAGAAGGC
AGTGTGGCTGGAGAAGGAGGAGAAGGCCAAGGCGCTGCGGGAGAAGCAGCTCCAGGAGCGCCGGCGCCGGCTGGAGGAGCAACGTCTTAA
AGCCGAGCAACGCCGTGCAGCCCTGGAGGAACGGCAGCGGCAGAAGCTCGAGAAAAACAAGGAGCGCTATGAAGCAGCCATCCAACGGTC
AGTGAAGAAGACGTGGGCCGAAATCCGGCAGCAGCGCTGGTCCTGGGCAGGGGCCCTGCACCACAGCTCTCCAGGACATAAGACCAATCG
CAGCCTGCAGCTGAGCGCATGGGAGAGCAGCATCGTGGATCGTCTGATGACGCCCACTCTCTCCTTCCTTGCTCGGAGTCGCAGCGCGGT
CACACTGCCCCGCAACGGCCGGGACCAGGGTAGGGGCTGCGACCCTGGGAGAGGCCCCACGTGGGGCCGGGCAGGGGCCAGCCTGGCGCG
CGGGCCGCAACCCGACCGCACTCATCCCTCTGCAGCCGTGCCGGTGTGCCCGCGCTCGGCCTCCGCCAGCCCCCTGACGCCGTGCAGCGT
CACCCGAAGCGTGCACCGCTGCGCCCCCGCCGGTGAGCGCGGGGAGCGCCGCAAGCCCAACGCCGGGGGCAGCCCCGCTCCGGTGCGCCG
CCGGCCGGAGGCCTCGCCGGTGCAGAAAAAGGAGAAGAAGGACAAGGAGCGGGAAAACGAGAAGGAGAAGAGTGCCCTAGCCCGGGAGCG
CAGCCTCAAGAAGCGCCAGTCGCTGCCCGCCTCCCCACGTGCCCGCCTCTCTGCCAGCACCGCCTCTGAGCTCAGCCCCAAATCCAAGGC
CAGGCCATCCTCTCCCTCCACATCCTGGCACAGGCCTGCCTCCCCCTGCCCCAGCCCAGGGCCAGGCCACACTCTGCCTCCAAAGCCACC
GTCCCCCCGAGGCACCACTGCATCCCCCAAGGGGCGGGTTCGGAGGAAGGAGGAGGCAAAGGAGAGCCCCAGCGCCGCAGGGCCCGAGGA
CAAGAGCCAGAGCAAGCGCAGGGCCAGTAACGAGAAGGAGTCAGCAGCCCCAGCCTCACCGGCACCTTCGCCGGCGCCCTCGCCCACCCC
AGCCCCGCCCCAGAAGGAGCAGCCCCCCGCGGAGACCCCTACAGACGCTGCTGTCTTGACCTCACCCCCAGCCCCTGCTCCCCCGGTGAC
CCCTAGCAAACCAATGGCCGGCACCACAGACCGAGAAGAAGCCACTCGGCTCTTGGCTGAGAAGCGGCGCCAGGCCCGGGAGCAGCGGGA
GCGCGAGGAGCAGGAGCGGAGGCTGCAGGCAGAAAGGGACAAGCGAATGCGAGAGGAGCAGCTGGCACGGGAGGCCGAGGCCCGGGCGGA
GCGGGAGGCGGAGGCCCGGAGGCGGGAGGAGCAGGAGGCACGAGAGAAGGCGCAGGCCGAGCAGGAGGAGCAGGAGCGGCTGCAGAAGCA
GAAAGAGGAGGCCGAAGCTCGGTCGCGGGAAGAGGCGGAGCGGCAGCGTCTGGAGCGGGAAAAGCACTTCCAGCAGCAGGAGCAAGAGCG
GCAAGAGCGCAGAAAGCGTCTGGAGGAGATCATGAAGAGGACTCGGAAGTCAGAAGTTTCTGAAACCAAGAAGCAGGACAGCAAGGAGGC
CAACGCCAACGGTTCCAGCCCAGAGCCTGTGAAAGCTGTGGAGGCTCGGTCCCCAGGGCTGCAGAAGGAGGCTGTGCAGAAAGAGGAGCC
CATCCCACAGGAGCCTCAGTGGAGTCTCCCAAGCAAGGAGTTGCCAGCGTCCCTGGTGAATGGCCTGCAGCCTCTCCCAGCACACCAGGA
GAATGGCTTCTCCACCAACGGACCCTCTGGGGACAAGAGTCTGAGCCGAACACCAGAGACACTCCTGCCCTTTGCAGAGGCAGAAGCCTT
CCTCAAGAAAGCTGTGGTGCAGTCCCCGCAGGTCACAGAAGTCCTTTAAGAGGGTTTGCCTTGGATCCGGGCACAGTTGTGAGGGCTCCT
CTGCATCACCTACCAGGATGTCTGGAGGAGAAAAAGACAGAACAAAGATGGAAGTGGCCTGGGCCCCTGGGGGTGGGTCCTCTCTGTTGT
TTTTAATCTGCACCTTATAGACTGATGTCTCTTTGGCCGGAGCCAGATCTGCCCCTCAGTGCATTCGTGTGCTCGCACGCGCAGACATCC
CTTCTCCCCCATACACACATATACACTCACAGCCTCTCTGGCCTCTTCCCTTGGGGAGGGGCCACCTGTAGTATTTGCCTTGATTTGGTG
GGGTACAGTGGATGTGAATACTGTAAATAGCTTGTGCTCAGACTCCTCTGCGTGGAGAGGGTGGGTGCAGGAGGCAGACCCTCCCCCCAA
AGCCCCCTGGGGAGATCTTCCTCTCTCTATTTAACTGTAACTGAGGGGGATCCCAGGTCTGGGGATGGGGGACACCTTGGGCCACAGGAT
ACTGGTTGCTTCAGGGGTACCCATGCCCCCTGCCCTCGCCTGGAATCAGTGTTACTGCATCTGATTAAATGTCTCCAGAAATAAAGAATA

>91411_91411_1_TMCO4-MAP7D1_TMCO4_chr1_20097035_ENST00000375127_MAP7D1_chr1_36636572_ENST00000316156_length(amino acids)=919AA_BP=123
MALGMAMWNRPCQRLPQQPLVAEPTAEGEPHLPTGRELTEANRFAYAALCGISLSQLFPEPEHSSFCTEFMAGLVQWLELSEAVLPTMTA
FASGLGGEGADVFVQILLKDPILKDDPTVITQDLLSFSLKDAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQL
PLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLA
AKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGH
KTNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVCPRSASASPLT
PCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSP
KSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAP
SPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAE
ARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKKQD
SKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETLLPFAE

--------------------------------------------------------------
>91411_91411_2_TMCO4-MAP7D1_TMCO4_chr1_20097035_ENST00000375127_MAP7D1_chr1_36636572_ENST00000373150_length(transcript)=3625nt_BP=653nt
CAAACAGAGAATTCCAGGAGGGCTTGGGGAGCCTCTGGAGAAAAACCAGGCTCCTCATGTTACAAGGAGGCCATGTCTTCTGGTGCCCAT
GCCTGAAGTTACAGGAGGGAAGAATTACTGCTGCTGACTTTTGAGTGGATTTTACAGCTGGGTAAACTGAGGCTCAGAGAGGGCAATTTG
CATATTTCTCCAAAGAACCATCCAGAACCTGAGCAGCCTGTCTTCAGACAGAGAGAGGCCCACGGCTGTTTCTTGAAATCTGGCGCTGGG
AATGGCCATGTGGAACAGGCCATGCCAGAGGCTGCCTCAGCAGCCTCTGGTAGCTGAGCCCACTGCAGAGGGGGAGCCACACCTGCCCAC
GGGCCGGGAGCTGACTGAGGCCAACCGCTTCGCCTATGCTGCCCTCTGTGGCATCTCCCTGTCCCAGTTATTTCCTGAACCCGAACACAG
CTCCTTCTGCACAGAGTTCATGGCAGGCCTGGTGCAGTGGCTGGAGTTGTCTGAAGCTGTCTTGCCAACCATGACTGCTTTTGCGAGCGG
CCTGGGAGGTGAAGGAGCAGATGTGTTTGTTCAAATTTTACTGAAGGACCCCATCTTGAAGGACGACCCGACGGTGATCACTCAGGACCT
TCTGAGCTTCTCACTCAAGGATGCTGTGGTCGCCAGGACCCCCCCAGAGCCAAGACCTTCTCCAGAAGGTGACCCTTCCCCCCCACCACC
ACCAATGTCAGCCCTGGTCCCCGACACTCCCCCGGACACCCCTCCTGCCATGAAGAATGCCACTAGCTCTAAGCAGCTCCCACTGGAACC
AGAGAGCCCCTCAGGGCAGGTCGGGCCTAGGCCAGCCCCCCCGCAGGAAGAGTCCCCTTCCTCTGAAGCAAAGAGCAGAGGACCCACCCC
ACCAGCCATGGGCCCACGGGATGCCAGACCTCCTCGAAGGAGCAGCCAGCCATCTCCAACAGCAGTGCCAGCCTCCGACAGCCCTCCCAC
CAAGCAAGAGGTGAAGAAGGCAGGAGAGAGACACAAGCTGGCAAAGGAGCGGCGAGAAGAGCGGGCCAAGTACCTGGCGGCCAAGAAGGC
AGTGTGGCTGGAGAAGGAGGAGAAGGCCAAGGCGCTGCGGGAGAAGCAGCTCCAGGAGCGCCGGCGCCGGCTGGAGGAGCAACGTCTTAA
AGCCGAGCAACGCCGTGCAGCCCTGGAGGAACGGCAGCGGCAGAAGCTCGAGAAAAACAAGGAGCGCTATGAAGCAGCCATCCAACGGTC
AGTGAAGAAGACGTGGGCCGAAATCCGGCAGCAGCGCTGGTCCTGGGCAGGGGCCCTGCACCACAGCTCTCCAGGACATAAGACCAGTGG
GAGCAGGTGCTCCGTGTCGGCAGTTAACCTGCCCAAACACGTGGACTCTATAATCAACAAGCGGCTCTCAAAGTCCTCTGCCACGCTCTG
GAACTCCCCCAGTAGAAATCGCAGCCTGCAGCTGAGCGCATGGGAGAGCAGCATCGTGGATCGTCTGATGACGCCCACTCTCTCCTTCCT
TGCTCGGAGTCGCAGCGCGGTCACACTGCCCCGCAACGGCCGGGACCAGGCCGTGCCGGTGTGCCCGCGCTCGGCCTCCGCCAGCCCCCT
GACGCCGTGCAGCGTCACCCGAAGCGTGCACCGCTGCGCCCCCGCCGGTGAGCGCGGGGAGCGCCGCAAGCCCAACGCCGGGGGCAGCCC
CGCTCCGGTGCGCCGCCGGCCGGAGGCCTCGCCGGTGCAGAAAAAGGAGAAGAAGGACAAGGAGCGGGAAAACGAGAAGGAGAAGAGTGC
CCTAGCCCGGGAGCGCAGCCTCAAGAAGCGCCAGTCGCTGCCCGCCTCCCCACGTGCCCGCCTCTCTGCCAGCACCGCCTCTGAGCTCAG
CCCCAAATCCAAGGCCAGGCCATCCTCTCCCTCCACATCCTGGCACAGGCCTGCCTCCCCCTGCCCCAGCCCAGGGCCAGGCCACACTCT
GCCTCCAAAGCCACCGTCCCCCCGAGGCACCACTGCATCCCCCAAGGGGCGGGTTCGGAGGAAGGAGGAGGCAAAGGAGAGCCCCAGCGC
CGCAGGGCCCGAGGACAAGAGCCAGAGCAAGCGCAGGGCCAGTAACGAGAAGGAGTCAGCAGCCCCAGCCTCACCGGCACCTTCGCCGGC
GCCCTCGCCCACCCCAGCCCCGCCCCAGAAGGAGCAGCCCCCCGCGGAGACCCCTACAGACGCTGCTGTCTTGACCTCACCCCCAGCCCC
TGCTCCCCCGGTGACCCCTAGCAAACCAATGGCCGGCACCACAGACCGAGAAGAAGCCACTCGGCTCTTGGCTGAGAAGCGGCGCCAGGC
CCGGGAGCAGCGGGAGCGCGAGGAGCAGGAGCGGAGGCTGCAGGCAGAAAGGGACAAGCGAATGCGAGAGGAGCAGCTGGCACGGGAGGC
CGAGGCCCGGGCGGAGCGGGAGGCGGAGGCCCGGAGGCGGGAGGAGCAGGAGGCACGAGAGAAGGCGCAGGCCGAGCAGGAGGAGCAGGA
GCGGCTGCAGAAGCAGAAAGAGGAGGCCGAAGCTCGGTCGCGGGAAGAGGCGGAGCGGCAGCGTCTGGAGCGGGAAAAGCACTTCCAGCA
GCAGGAGCAAGAGCGGCAAGAGCGCAGAAAGCGTCTGGAGGAGATCATGAAGAGGACTCGGAAGTCAGAAGTTTCTGAAACCAAGAAGCA
GGACAGCAAGGAGGCCAACGCCAACGGTTCCAGCCCAGAGCCTGTGAAAGCTGTGGAGGCTCGGTCCCCAGGGCTGCAGAAGGAGGCTGT
GCAGAAAGAGGAGCCCATCCCACAGGAGCCTCAGTGGAGTCTCCCAAGCAAGGAGTTGCCAGCGTCCCTGGTGAATGGCCTGCAGCCTCT
CCCAGCACACCAGGAGAATGGCTTCTCCACCAACGGACCCTCTGGGGACAAGAGTCTGAGCCGAACACCAGAGACACTCCTGCCCTTTGC
AGAGGCAGAAGCCTTCCTCAAGAAAGCTGTGGTGCAGTCCCCGCAGGTCACAGAAGTCCTTTAAGAGGGTTTGCCTTGGATCCGGGCACA
GTTGTGAGGGCTCCTCTGCATCACCTACCAGGATGTCTGGAGGAGAAAAAGACAGAACAAAGATGGAAGTGGCCTGGGCCCCTGGGGGTG
GGTCCTCTCTGTTGTTTTTAATCTGCACCTTATAGACTGATGTCTCTTTGGCCGGAGCCAGATCTGCCCCTCAGTGCATTCGTGTGCTCG
CACGCGCAGACATCCCTTCTCCCCCATACACACATATACACTCACAGCCTCTCTGGCCTCTTCCCTTGGGGAGGGGCCACCTGTAGTATT
TGCCTTGATTTGGTGGGGTACAGTGGATGTGAATACTGTAAATAGCTTGTGCTCAGACTCCTCTGCGTGGAGAGGGTGGGTGCAGGAGGC
AGACCCTCCCCCCAAAGCCCCCTGGGGAGATCTTCCTCTCTCTATTTAACTGTAACTGAGGGGGATCCCAGGTCTGGGGATGGGGGACAC
CTTGGGCCACAGGATACTGGTTGCTTCAGGGGTACCCATGCCCCCTGCCCTCGCCTGGAATCAGTGTTACTGCATCTGATTAAATGTCTC

>91411_91411_2_TMCO4-MAP7D1_TMCO4_chr1_20097035_ENST00000375127_MAP7D1_chr1_36636572_ENST00000373150_length(amino acids)=924AA_BP=123
MALGMAMWNRPCQRLPQQPLVAEPTAEGEPHLPTGRELTEANRFAYAALCGISLSQLFPEPEHSSFCTEFMAGLVQWLELSEAVLPTMTA
FASGLGGEGADVFVQILLKDPILKDDPTVITQDLLSFSLKDAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQL
PLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLA
AKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGH
KTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQAVPVCPRSAS
ASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTA
SELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPA
PSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQL
AREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSE
TKKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTPETL

--------------------------------------------------------------
>91411_91411_3_TMCO4-MAP7D1_TMCO4_chr1_20097035_ENST00000375127_MAP7D1_chr1_36636572_ENST00000373151_length(transcript)=3715nt_BP=653nt
CAAACAGAGAATTCCAGGAGGGCTTGGGGAGCCTCTGGAGAAAAACCAGGCTCCTCATGTTACAAGGAGGCCATGTCTTCTGGTGCCCAT
GCCTGAAGTTACAGGAGGGAAGAATTACTGCTGCTGACTTTTGAGTGGATTTTACAGCTGGGTAAACTGAGGCTCAGAGAGGGCAATTTG
CATATTTCTCCAAAGAACCATCCAGAACCTGAGCAGCCTGTCTTCAGACAGAGAGAGGCCCACGGCTGTTTCTTGAAATCTGGCGCTGGG
AATGGCCATGTGGAACAGGCCATGCCAGAGGCTGCCTCAGCAGCCTCTGGTAGCTGAGCCCACTGCAGAGGGGGAGCCACACCTGCCCAC
GGGCCGGGAGCTGACTGAGGCCAACCGCTTCGCCTATGCTGCCCTCTGTGGCATCTCCCTGTCCCAGTTATTTCCTGAACCCGAACACAG
CTCCTTCTGCACAGAGTTCATGGCAGGCCTGGTGCAGTGGCTGGAGTTGTCTGAAGCTGTCTTGCCAACCATGACTGCTTTTGCGAGCGG
CCTGGGAGGTGAAGGAGCAGATGTGTTTGTTCAAATTTTACTGAAGGACCCCATCTTGAAGGACGACCCGACGGTGATCACTCAGGACCT
TCTGAGCTTCTCACTCAAGGATGCTGTGGTCGCCAGGACCCCCCCAGAGCCAAGACCTTCTCCAGAAGGTGACCCTTCCCCCCCACCACC
ACCAATGTCAGCCCTGGTCCCCGACACTCCCCCGGACACCCCTCCTGCCATGAAGAATGCCACTAGCTCTAAGCAGCTCCCACTGGAACC
AGAGAGCCCCTCAGGGCAGGTCGGGCCTAGGCCAGCCCCCCCGCAGGAAGAGTCCCCTTCCTCTGAAGCAAAGAGCAGAGGACCCACCCC
ACCAGCCATGGGCCCACGGGATGCCAGACCTCCTCGAAGGAGCAGCCAGCCATCTCCAACAGCAGTGCCAGCCTCCGACAGCCCTCCCAC
CAAGCAAGAGGTGAAGAAGGCAGGAGAGAGACACAAGCTGGCAAAGGAGCGGCGAGAAGAGCGGGCCAAGTACCTGGCGGCCAAGAAGGC
AGTGTGGCTGGAGAAGGAGGAGAAGGCCAAGGCGCTGCGGGAGAAGCAGCTCCAGGAGCGCCGGCGCCGGCTGGAGGAGCAACGTCTTAA
AGCCGAGCAACGCCGTGCAGCCCTGGAGGAACGGCAGCGGCAGAAGCTCGAGAAAAACAAGGAGCGCTATGAAGCAGCCATCCAACGGTC
AGTGAAGAAGACGTGGGCCGAAATCCGGCAGCAGCGCTGGTCCTGGGCAGGGGCCCTGCACCACAGCTCTCCAGGACATAAGACCAGTGG
GAGCAGGTGCTCCGTGTCGGCAGTTAACCTGCCCAAACACGTGGACTCTATAATCAACAAGCGGCTCTCAAAGTCCTCTGCCACGCTCTG
GAACTCCCCCAGTAGAAATCGCAGCCTGCAGCTGAGCGCATGGGAGAGCAGCATCGTGGATCGTCTGATGACGCCCACTCTCTCCTTCCT
TGCTCGGAGTCGCAGCGCGGTCACACTGCCCCGCAACGGCCGGGACCAGGGTAGGGGCTGCGACCCTGGGAGAGGCCCCACGTGGGGCCG
GGCAGGGGCCAGCCTGGCGCGCGGGCCGCAACCCGACCGCACTCATCCCTCTGCAGCCGTGCCGGTGTGCCCGCGCTCGGCCTCCGCCAG
CCCCCTGACGCCGTGCAGCGTCACCCGAAGCGTGCACCGCTGCGCCCCCGCCGGTGAGCGCGGGGAGCGCCGCAAGCCCAACGCCGGGGG
CAGCCCCGCTCCGGTGCGCCGCCGGCCGGAGGCCTCGCCGGTGCAGAAAAAGGAGAAGAAGGACAAGGAGCGGGAAAACGAGAAGGAGAA
GAGTGCCCTAGCCCGGGAGCGCAGCCTCAAGAAGCGCCAGTCGCTGCCCGCCTCCCCACGTGCCCGCCTCTCTGCCAGCACCGCCTCTGA
GCTCAGCCCCAAATCCAAGGCCAGGCCATCCTCTCCCTCCACATCCTGGCACAGGCCTGCCTCCCCCTGCCCCAGCCCAGGGCCAGGCCA
CACTCTGCCTCCAAAGCCACCGTCCCCCCGAGGCACCACTGCATCCCCCAAGGGGCGGGTTCGGAGGAAGGAGGAGGCAAAGGAGAGCCC
CAGCGCCGCAGGGCCCGAGGACAAGAGCCAGAGCAAGCGCAGGGCCAGTAACGAGAAGGAGTCAGCAGCCCCAGCCTCACCGGCACCTTC
GCCGGCGCCCTCGCCCACCCCAGCCCCGCCCCAGAAGGAGCAGCCCCCCGCGGAGACCCCTACAGACGCTGCTGTCTTGACCTCACCCCC
AGCCCCTGCTCCCCCGGTGACCCCTAGCAAACCAATGGCCGGCACCACAGACCGAGAAGAAGCCACTCGGCTCTTGGCTGAGAAGCGGCG
CCAGGCCCGGGAGCAGCGGGAGCGCGAGGAGCAGGAGCGGAGGCTGCAGGCAGAAAGGGACAAGCGAATGCGAGAGGAGCAGCTGGCACG
GGAGGCCGAGGCCCGGGCGGAGCGGGAGGCGGAGGCCCGGAGGCGGGAGGAGCAGGAGGCACGAGAGAAGGCGCAGGCCGAGCAGGAGGA
GCAGGAGCGGCTGCAGAAGCAGAAAGAGGAGGCCGAAGCTCGGTCGCGGGAAGAGGCGGAGCGGCAGCGTCTGGAGCGGGAAAAGCACTT
CCAGCAGCAGGAGCAAGAGCGGCAAGAGCGCAGAAAGCGTCTGGAGGAGATCATGAAGAGGACTCGGAAGTCAGAAGTTTCTGAAACCAA
GCAGAAGCAGGACAGCAAGGAGGCCAACGCCAACGGTTCCAGCCCAGAGCCTGTGAAAGCTGTGGAGGCTCGGTCCCCAGGGCTGCAGAA
GGAGGCTGTGCAGAAAGAGGAGCCCATCCCACAGGAGCCTCAGTGGAGTCTCCCAAGCAAGGAGTTGCCAGCGTCCCTGGTGAATGGCCT
GCAGCCTCTCCCAGCACACCAGGAGAATGGCTTCTCCACCAACGGACCCTCTGGGGACAAGAGTCTGAGCCGAACACCAGAGACACTCCT
GCCCTTTGCAGAGGCAGAAGCCTTCCTCAAGAAAGCTGTGGTGCAGTCCCCGCAGGTCACAGAAGTCCTTTAAGAGGGTTTGCCTTGGAT
CCGGGCACAGTTGTGAGGGCTCCTCTGCATCACCTACCAGGATGTCTGGAGGAGAAAAAGACAGAACAAAGATGGAAGTGGCCTGGGCCC
CTGGGGGTGGGTCCTCTCTGTTGTTTTTAATCTGCACCTTATAGACTGATGTCTCTTTGGCCGGAGCCAGATCTGCCCCTCAGTGCATTC
GTGTGCTCGCACGCGCAGACATCCCTTCTCCCCCATACACACATATACACTCACAGCCTCTCTGGCCTCTTCCCTTGGGGAGGGGCCACC
TGTAGTATTTGCCTTGATTTGGTGGGGTACAGTGGATGTGAATACTGTAAATAGCTTGTGCTCAGACTCCTCTGCGTGGAGAGGGTGGGT
GCAGGAGGCAGACCCTCCCCCCAAAGCCCCCTGGGGAGATCTTCCTCTCTCTATTTAACTGTAACTGAGGGGGATCCCAGGTCTGGGGAT
GGGGGACACCTTGGGCCACAGGATACTGGTTGCTTCAGGGGTACCCATGCCCCCTGCCCTCGCCTGGAATCAGTGTTACTGCATCTGATT

>91411_91411_3_TMCO4-MAP7D1_TMCO4_chr1_20097035_ENST00000375127_MAP7D1_chr1_36636572_ENST00000373151_length(amino acids)=957AA_BP=123
MALGMAMWNRPCQRLPQQPLVAEPTAEGEPHLPTGRELTEANRFAYAALCGISLSQLFPEPEHSSFCTEFMAGLVQWLELSEAVLPTMTA
FASGLGGEGADVFVQILLKDPILKDDPTVITQDLLSFSLKDAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQL
PLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLA
AKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGH
KTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGP
TWGRAGASLARGPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKEREN
EKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEA
KESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLA
EKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLER
EKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMCO4-MAP7D1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMCO4-MAP7D1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMCO4-MAP7D1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource