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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMCO6-CYSTM1 (FusionGDB2 ID:91417)

Fusion Gene Summary for TMCO6-CYSTM1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMCO6-CYSTM1
Fusion gene ID: 91417
HgeneTgene
Gene symbol

TMCO6

CYSTM1

Gene ID

55374

84418

Gene nametransmembrane and coiled-coil domains 6cysteine rich transmembrane module containing 1
SynonymsPRO1580C5orf32|ORF1-FL49
Cytomap

5q31.3

5q31.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane and coiled-coil domain-containing protein 6cysteine-rich and transmembrane domain-containing protein 1UPF0467 protein C5orf32putative nuclear protein ORF1-FL49
Modification date2020031320200313
UniProtAcc.

Q9H1C7

Ensembl transtripts involved in fusion geneENST00000252100, ENST00000394671, 
ENST00000511410, ENST00000537378, 
ENST00000509789, ENST00000261811, 
Fusion gene scores* DoF score2 X 1 X 2=426 X 7 X 13=2366
# samples 334
** MAII scorelog2(3/4*10)=2.90689059560852log2(34/2366*10)=-2.79884342220209
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMCO6 [Title/Abstract] AND CYSTM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMCO6(140021365)-CYSTM1(139622890), # samples:2
Anticipated loss of major functional domain due to fusion event.TMCO6-CYSTM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMCO6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CYSTM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-CC-5263-01ATMCO6chr5

140021365

+CYSTM1chr5

139622890

+
ChimerDB4LIHCTCGA-CC-5263TMCO6chr5

140021365

+CYSTM1chr5

139622889

+


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Fusion Gene ORF analysis for TMCO6-CYSTM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000252100ENST00000509789TMCO6chr5

140021365

+CYSTM1chr5

139622890

+
5CDS-3UTRENST00000252100ENST00000509789TMCO6chr5

140021365

+CYSTM1chr5

139622889

+
5CDS-3UTRENST00000394671ENST00000509789TMCO6chr5

140021365

+CYSTM1chr5

139622890

+
5CDS-3UTRENST00000394671ENST00000509789TMCO6chr5

140021365

+CYSTM1chr5

139622889

+
5CDS-3UTRENST00000511410ENST00000509789TMCO6chr5

140021365

+CYSTM1chr5

139622890

+
5CDS-3UTRENST00000511410ENST00000509789TMCO6chr5

140021365

+CYSTM1chr5

139622889

+
5UTR-3CDSENST00000537378ENST00000261811TMCO6chr5

140021365

+CYSTM1chr5

139622890

+
5UTR-3CDSENST00000537378ENST00000261811TMCO6chr5

140021365

+CYSTM1chr5

139622889

+
5UTR-3UTRENST00000537378ENST00000509789TMCO6chr5

140021365

+CYSTM1chr5

139622890

+
5UTR-3UTRENST00000537378ENST00000509789TMCO6chr5

140021365

+CYSTM1chr5

139622889

+
Frame-shiftENST00000511410ENST00000261811TMCO6chr5

140021365

+CYSTM1chr5

139622890

+
Frame-shiftENST00000511410ENST00000261811TMCO6chr5

140021365

+CYSTM1chr5

139622889

+
In-frameENST00000252100ENST00000261811TMCO6chr5

140021365

+CYSTM1chr5

139622890

+
In-frameENST00000252100ENST00000261811TMCO6chr5

140021365

+CYSTM1chr5

139622889

+
In-frameENST00000394671ENST00000261811TMCO6chr5

140021365

+CYSTM1chr5

139622890

+
In-frameENST00000394671ENST00000261811TMCO6chr5

140021365

+CYSTM1chr5

139622889

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394671TMCO6chr5140021365+ENST00000261811CYSTM1chr5139622890+8984154561152
ENST00000252100TMCO6chr5140021365+ENST00000261811CYSTM1chr5139622890+8213383792126
ENST00000394671TMCO6chr5140021365+ENST00000261811CYSTM1chr5139622889+8984154561152
ENST00000252100TMCO6chr5140021365+ENST00000261811CYSTM1chr5139622889+8213383792126

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394671ENST00000261811TMCO6chr5140021365+CYSTM1chr5139622890+0.213071750.78692824
ENST00000252100ENST00000261811TMCO6chr5140021365+CYSTM1chr5139622890+0.153374480.84662557
ENST00000394671ENST00000261811TMCO6chr5140021365+CYSTM1chr5139622889+0.213071750.78692824
ENST00000252100ENST00000261811TMCO6chr5140021365+CYSTM1chr5139622889+0.153374480.84662557

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Fusion Genomic Features for TMCO6-CYSTM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMCO6chr5140021365+CYSTM1chr5139622889+0.0054901860.9945098
TMCO6chr5140021365+CYSTM1chr5139622889+0.0054901860.9945098
TMCO6chr5140021365+CYSTM1chr5139622889+0.0054901860.9945098
TMCO6chr5140021365+CYSTM1chr5139622889+0.0054901860.9945098

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMCO6-CYSTM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:140021365/chr5:139622890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CYSTM1

Q9H1C7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMCO6chr5:140021365chr5:139622889ENST00000252100+31215_84104500.0Coiled coilOntology_term=ECO:0000255
HgeneTMCO6chr5:140021365chr5:139622889ENST00000394671+31215_84104494.0Coiled coilOntology_term=ECO:0000255
HgeneTMCO6chr5:140021365chr5:139622890ENST00000252100+31215_84104500.0Coiled coilOntology_term=ECO:0000255
HgeneTMCO6chr5:140021365chr5:139622890ENST00000394671+31215_84104494.0Coiled coilOntology_term=ECO:0000255
HgeneTMCO6chr5:140021365chr5:139622889ENST00000252100+3122_79104500.0Compositional biasNote=Arg-rich
HgeneTMCO6chr5:140021365chr5:139622889ENST00000394671+3122_79104494.0Compositional biasNote=Arg-rich
HgeneTMCO6chr5:140021365chr5:139622890ENST00000252100+3122_79104500.0Compositional biasNote=Arg-rich
HgeneTMCO6chr5:140021365chr5:139622890ENST00000394671+3122_79104494.0Compositional biasNote=Arg-rich
TgeneCYSTM1chr5:140021365chr5:139622889ENST000002618111388_916298.0Compositional biasNote=Poly-Cys
TgeneCYSTM1chr5:140021365chr5:139622890ENST000002618111388_916298.0Compositional biasNote=Poly-Cys
TgeneCYSTM1chr5:140021365chr5:139622889ENST000002618111374_916298.0TransmembraneHelical
TgeneCYSTM1chr5:140021365chr5:139622890ENST000002618111374_916298.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMCO6chr5:140021365chr5:139622889ENST00000537378+31015_840254.0Coiled coilOntology_term=ECO:0000255
HgeneTMCO6chr5:140021365chr5:139622890ENST00000537378+31015_840254.0Coiled coilOntology_term=ECO:0000255
HgeneTMCO6chr5:140021365chr5:139622889ENST00000537378+3102_790254.0Compositional biasNote=Arg-rich
HgeneTMCO6chr5:140021365chr5:139622890ENST00000537378+3102_790254.0Compositional biasNote=Arg-rich
HgeneTMCO6chr5:140021365chr5:139622889ENST00000252100+312338_358104500.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622889ENST00000252100+312386_406104500.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622889ENST00000394671+312338_358104494.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622889ENST00000394671+312386_406104494.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622889ENST00000537378+310338_3580254.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622889ENST00000537378+310386_4060254.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622890ENST00000252100+312338_358104500.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622890ENST00000252100+312386_406104500.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622890ENST00000394671+312338_358104494.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622890ENST00000394671+312386_406104494.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622890ENST00000537378+310338_3580254.0TransmembraneHelical
HgeneTMCO6chr5:140021365chr5:139622890ENST00000537378+310386_4060254.0TransmembraneHelical
TgeneCYSTM1chr5:140021365chr5:139622889ENST00000261811136_596298.0Compositional biasNote=Pro-rich
TgeneCYSTM1chr5:140021365chr5:139622890ENST00000261811136_596298.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for TMCO6-CYSTM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91417_91417_1_TMCO6-CYSTM1_TMCO6_chr5_140021365_ENST00000252100_CYSTM1_chr5_139622889_ENST00000261811_length(transcript)=821nt_BP=338nt
CGGCTTTCCTCCTCCTGCTCCACCATGTGGAGCCGACGGCAGGGCCGCCTCAGGCCCACGGTCTGCGGGGTGGAGGAGCTACGGCGCCGC
CGGCGGGAGCGGGAGGCAGCACTGCGGAAGGCGCGGAGGGAGCAGCAGCTGGTCAGCAAGAGGCTGCTGAGAAACGACGCCCCAGAGGAA
GCTGGAGAGGGATGTGTGGCTGCGATCCTCGGGGAAACCGAGGTGCAGCAGTTCCTGCGGCAAGCCCAGCGGGGGACAGAGGAAAAGGAG
AGAGAGGGGGCTCTGGTCAGCCTTCGTCGAGGCTTGCAGCACCCTGAAACACAGCAAACCTTCATCCGTGTATGTGGTAGAAGACCAAAG
AAGAGATGAGCTAGGACCATCCACCTGCCTCACAGCCTGCTGGACGGCTCTCTGTTGCTGCTGTCTCTGGGACATGCTCACCTGACCAGA
CCAGCCCAGCCGTCCTGTCCTGCCAGCTCTGCTGCCACCTCTGACAGGTGTGCCTGCCCCCATCTCTTCTGATTGCTGTTAACAAATGAC
TAGCTTTGCACAGACACCTCTACCTTCAGCACTATGGGATTCTAGATTAATGGGGGTTGCTACTGTTTAATTCAGTGACTTGATCTTTTT
AATGTCCAAAATCCATTTCTTATTGATCTTTAAAGATGTGCTAAATGACTTTTTTGGCCAAAGGCTTAGTTGTGAAAAATATAATTTTTA
AATTATACATTCAAGGTAGTGGCCAAATGTAACACATCAATCATGGAATGATTTCTCTGCTAACAGCCGCCTGTATGTTTCAATAAATTT

>91417_91417_1_TMCO6-CYSTM1_TMCO6_chr5_140021365_ENST00000252100_CYSTM1_chr5_139622889_ENST00000261811_length(amino acids)=126AA_BP=0
MVLAHLFFGLLPHTRMKVCCVSGCCKPRRRLTRAPSLSFSSVPRWACRRNCCTSVSPRIAATHPSPASSGASFLSSLLLTSCCSLRAFRS

--------------------------------------------------------------
>91417_91417_2_TMCO6-CYSTM1_TMCO6_chr5_140021365_ENST00000252100_CYSTM1_chr5_139622890_ENST00000261811_length(transcript)=821nt_BP=338nt
CGGCTTTCCTCCTCCTGCTCCACCATGTGGAGCCGACGGCAGGGCCGCCTCAGGCCCACGGTCTGCGGGGTGGAGGAGCTACGGCGCCGC
CGGCGGGAGCGGGAGGCAGCACTGCGGAAGGCGCGGAGGGAGCAGCAGCTGGTCAGCAAGAGGCTGCTGAGAAACGACGCCCCAGAGGAA
GCTGGAGAGGGATGTGTGGCTGCGATCCTCGGGGAAACCGAGGTGCAGCAGTTCCTGCGGCAAGCCCAGCGGGGGACAGAGGAAAAGGAG
AGAGAGGGGGCTCTGGTCAGCCTTCGTCGAGGCTTGCAGCACCCTGAAACACAGCAAACCTTCATCCGTGTATGTGGTAGAAGACCAAAG
AAGAGATGAGCTAGGACCATCCACCTGCCTCACAGCCTGCTGGACGGCTCTCTGTTGCTGCTGTCTCTGGGACATGCTCACCTGACCAGA
CCAGCCCAGCCGTCCTGTCCTGCCAGCTCTGCTGCCACCTCTGACAGGTGTGCCTGCCCCCATCTCTTCTGATTGCTGTTAACAAATGAC
TAGCTTTGCACAGACACCTCTACCTTCAGCACTATGGGATTCTAGATTAATGGGGGTTGCTACTGTTTAATTCAGTGACTTGATCTTTTT
AATGTCCAAAATCCATTTCTTATTGATCTTTAAAGATGTGCTAAATGACTTTTTTGGCCAAAGGCTTAGTTGTGAAAAATATAATTTTTA
AATTATACATTCAAGGTAGTGGCCAAATGTAACACATCAATCATGGAATGATTTCTCTGCTAACAGCCGCCTGTATGTTTCAATAAATTT

>91417_91417_2_TMCO6-CYSTM1_TMCO6_chr5_140021365_ENST00000252100_CYSTM1_chr5_139622890_ENST00000261811_length(amino acids)=126AA_BP=0
MVLAHLFFGLLPHTRMKVCCVSGCCKPRRRLTRAPSLSFSSVPRWACRRNCCTSVSPRIAATHPSPASSGASFLSSLLLTSCCSLRAFRS

--------------------------------------------------------------
>91417_91417_3_TMCO6-CYSTM1_TMCO6_chr5_140021365_ENST00000394671_CYSTM1_chr5_139622889_ENST00000261811_length(transcript)=898nt_BP=415nt
GTTCCCGCCCTGTGCTGAGGCTGCGCAGTCGGTGCCATCTTCTACGCCCCTGGGAGCGTTGTGGCTGCTGTTTCCTTCGGCTTTCCTCCT
CCTGCTCCACCATGTGGAGCCGACGGCAGGGCCGCCTCAGGCCCACGGTCTGCGGGGTGGAGGAGCTACGGCGCCGCCGGCGGGAGCGGG
AGGCAGCACTGCGGAAGGCGCGGAGGGAGCAGCAGCTGGTCAGCAAGAGGCTGCTGAGAAACGACGCCCCAGAGGAAGCTGGAGAGGGAT
GTGTGGCTGCGATCCTCGGGGAAACCGAGGTGCAGCAGTTCCTGCGGCAAGCCCAGCGGGGGACAGAGGAAAAGGAGAGAGAGGGGGCTC
TGGTCAGCCTTCGTCGAGGCTTGCAGCACCCTGAAACACAGCAAACCTTCATCCGTGTATGTGGTAGAAGACCAAAGAAGAGATGAGCTA
GGACCATCCACCTGCCTCACAGCCTGCTGGACGGCTCTCTGTTGCTGCTGTCTCTGGGACATGCTCACCTGACCAGACCAGCCCAGCCGT
CCTGTCCTGCCAGCTCTGCTGCCACCTCTGACAGGTGTGCCTGCCCCCATCTCTTCTGATTGCTGTTAACAAATGACTAGCTTTGCACAG
ACACCTCTACCTTCAGCACTATGGGATTCTAGATTAATGGGGGTTGCTACTGTTTAATTCAGTGACTTGATCTTTTTAATGTCCAAAATC
CATTTCTTATTGATCTTTAAAGATGTGCTAAATGACTTTTTTGGCCAAAGGCTTAGTTGTGAAAAATATAATTTTTAAATTATACATTCA

>91417_91417_3_TMCO6-CYSTM1_TMCO6_chr5_140021365_ENST00000394671_CYSTM1_chr5_139622889_ENST00000261811_length(amino acids)=152AA_BP=0
MVLAHLFFGLLPHTRMKVCCVSGCCKPRRRLTRAPSLSFSSVPRWACRRNCCTSVSPRIAATHPSPASSGASFLSSLLLTSCCSLRAFRS

--------------------------------------------------------------
>91417_91417_4_TMCO6-CYSTM1_TMCO6_chr5_140021365_ENST00000394671_CYSTM1_chr5_139622890_ENST00000261811_length(transcript)=898nt_BP=415nt
GTTCCCGCCCTGTGCTGAGGCTGCGCAGTCGGTGCCATCTTCTACGCCCCTGGGAGCGTTGTGGCTGCTGTTTCCTTCGGCTTTCCTCCT
CCTGCTCCACCATGTGGAGCCGACGGCAGGGCCGCCTCAGGCCCACGGTCTGCGGGGTGGAGGAGCTACGGCGCCGCCGGCGGGAGCGGG
AGGCAGCACTGCGGAAGGCGCGGAGGGAGCAGCAGCTGGTCAGCAAGAGGCTGCTGAGAAACGACGCCCCAGAGGAAGCTGGAGAGGGAT
GTGTGGCTGCGATCCTCGGGGAAACCGAGGTGCAGCAGTTCCTGCGGCAAGCCCAGCGGGGGACAGAGGAAAAGGAGAGAGAGGGGGCTC
TGGTCAGCCTTCGTCGAGGCTTGCAGCACCCTGAAACACAGCAAACCTTCATCCGTGTATGTGGTAGAAGACCAAAGAAGAGATGAGCTA
GGACCATCCACCTGCCTCACAGCCTGCTGGACGGCTCTCTGTTGCTGCTGTCTCTGGGACATGCTCACCTGACCAGACCAGCCCAGCCGT
CCTGTCCTGCCAGCTCTGCTGCCACCTCTGACAGGTGTGCCTGCCCCCATCTCTTCTGATTGCTGTTAACAAATGACTAGCTTTGCACAG
ACACCTCTACCTTCAGCACTATGGGATTCTAGATTAATGGGGGTTGCTACTGTTTAATTCAGTGACTTGATCTTTTTAATGTCCAAAATC
CATTTCTTATTGATCTTTAAAGATGTGCTAAATGACTTTTTTGGCCAAAGGCTTAGTTGTGAAAAATATAATTTTTAAATTATACATTCA

>91417_91417_4_TMCO6-CYSTM1_TMCO6_chr5_140021365_ENST00000394671_CYSTM1_chr5_139622890_ENST00000261811_length(amino acids)=152AA_BP=0
MVLAHLFFGLLPHTRMKVCCVSGCCKPRRRLTRAPSLSFSSVPRWACRRNCCTSVSPRIAATHPSPASSGASFLSSLLLTSCCSLRAFRS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMCO6-CYSTM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMCO6-CYSTM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMCO6-CYSTM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource