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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEFF2-CHMP1A (FusionGDB2 ID:91490)

Fusion Gene Summary for TMEFF2-CHMP1A

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEFF2-CHMP1A
Fusion gene ID: 91490
HgeneTgene
Gene symbol

TMEFF2

CHMP1A

Gene ID

23671

5119

Gene nametransmembrane protein with EGF like and two follistatin like domains 2charged multivesicular body protein 1A
SynonymsCT120.2|HPP1|TENB2|TPEF|TR|TR-2CHMP1|PCH8|PCOLN3|PRSM1|VPS46-1|VPS46A
Cytomap

2q32.3

16q24.3

Type of geneprotein-codingprotein-coding
Descriptiontomoregulin-2cancer/testis antigen family 120, member 2hyperplastic polyposis protein 1transmembrane protein TENB2transmembrane protein with EGF-like and two follistatin-like domainscharged multivesicular body protein 1acharged multivesicular body protein 1/chromatin modifying protein 1chromatin modifying protein 1Aprocollagen (type III) N-endopeptidaseprotease, metallo, 1, 33kDvacuolar protein sorting-associated protein 46-1
Modification date2020031320200313
UniProtAcc.

Q9HD42

Ensembl transtripts involved in fusion geneENST00000272771, ENST00000392314, 
ENST00000409056, ENST00000487771, 
ENST00000547614, ENST00000397901, 
ENST00000535997, ENST00000550102, 
ENST00000253475, 
Fusion gene scores* DoF score9 X 7 X 2=12645 X 11 X 21=10395
# samples 1048
** MAII scorelog2(10/126*10)=-0.333423733725192
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10395*10)=-4.43671154213721
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEFF2 [Title/Abstract] AND CHMP1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEFF2(193044394)-CHMP1A(89713739), # samples:2
Anticipated loss of major functional domain due to fusion event.TMEFF2-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEFF2

GO:0030336

negative regulation of cell migration

24632071

HgeneTMEFF2

GO:0044319

wound healing, spreading of cells

24632071

HgeneTMEFF2

GO:0051497

negative regulation of stress fiber assembly

24632071

TgeneCHMP1A

GO:0007076

mitotic chromosome condensation

11559747

TgeneCHMP1A

GO:0016192

vesicle-mediated transport

11559748

TgeneCHMP1A

GO:0016458

gene silencing

11559747

TgeneCHMP1A

GO:0045892

negative regulation of transcription, DNA-templated

11559747


check buttonFusion gene breakpoints across TMEFF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CHMP1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-7318-01BTMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
ChimerDB4PRADTCGA-G9-6332-01ATMEFF2chr2

193044394

-CHMP1Achr16

89713739

-


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Fusion Gene ORF analysis for TMEFF2-CHMP1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000272771ENST00000547614TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
5CDS-5UTRENST00000392314ENST00000547614TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
Frame-shiftENST00000272771ENST00000397901TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
Frame-shiftENST00000272771ENST00000535997TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
Frame-shiftENST00000272771ENST00000550102TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
Frame-shiftENST00000392314ENST00000397901TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
Frame-shiftENST00000392314ENST00000535997TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
Frame-shiftENST00000392314ENST00000550102TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
In-frameENST00000272771ENST00000253475TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
In-frameENST00000392314ENST00000253475TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-3CDSENST00000409056ENST00000253475TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-3CDSENST00000409056ENST00000397901TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-3CDSENST00000409056ENST00000535997TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-3CDSENST00000409056ENST00000550102TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-3CDSENST00000487771ENST00000253475TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-3CDSENST00000487771ENST00000397901TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-3CDSENST00000487771ENST00000535997TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-3CDSENST00000487771ENST00000550102TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-5UTRENST00000409056ENST00000547614TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-
intron-5UTRENST00000487771ENST00000547614TMEFF2chr2

193044394

-CHMP1Achr16

89713739

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392314TMEFF2chr2193044394-ENST00000253475CHMP1Achr1689713739-27988313771321314
ENST00000272771TMEFF2chr2193044394-ENST00000253475CHMP1Achr1689713739-3591162411702114314

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392314ENST00000253475TMEFF2chr2193044394-CHMP1Achr1689713739-0.160208280.8397917
ENST00000272771ENST00000253475TMEFF2chr2193044394-CHMP1Achr1689713739-0.159138350.8408616

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Fusion Genomic Features for TMEFF2-CHMP1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEFF2-CHMP1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:193044394/chr16:89713739)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CHMP1A

Q9HD42

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. {ECO:0000269|PubMed:11559747, ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:23045692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000272771-41085_137146375.0DomainKazal-like 1
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000392314-41085_137146347.0DomainKazal-like 1
TgeneCHMP1Achr2:193044394chr16:89713739ENST0000039790137102_12484197.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP1Achr2:193044394chr16:89713739ENST0000039790137185_19584197.0MotifNote=MIT-interacting motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000272771-410176_229146375.0DomainKazal-like 2
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000272771-410261_301146375.0DomainEGF-like
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000392314-410176_229146347.0DomainKazal-like 2
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000392314-410261_301146347.0DomainEGF-like
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000409056-14176_2290176.0DomainKazal-like 2
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000409056-14261_3010176.0DomainEGF-like
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000409056-1485_1370176.0DomainKazal-like 1
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000272771-410303_320146375.0RegionNote=Required for shedding
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000392314-410303_320146347.0RegionNote=Required for shedding
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000409056-14303_3200176.0RegionNote=Required for shedding
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000272771-410342_374146375.0Topological domainCytoplasmic
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000272771-41041_320146375.0Topological domainExtracellular
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000392314-410342_374146347.0Topological domainCytoplasmic
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000392314-41041_320146347.0Topological domainExtracellular
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000409056-14342_3740176.0Topological domainCytoplasmic
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000409056-1441_3200176.0Topological domainExtracellular
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000272771-410321_341146375.0TransmembraneHelical
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000392314-410321_341146347.0TransmembraneHelical
HgeneTMEFF2chr2:193044394chr16:89713739ENST00000409056-14321_3410176.0TransmembraneHelical
TgeneCHMP1Achr2:193044394chr16:89713739ENST00000397901375_4784197.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for TMEFF2-CHMP1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91490_91490_1_TMEFF2-CHMP1A_TMEFF2_chr2_193044394_ENST00000272771_CHMP1A_chr16_89713739_ENST00000253475_length(transcript)=3591nt_BP=1624nt
AAACCTGCGAACGCTTGGGCTGGGTCGGAGCTGCGGGGGGCCTGGGAGGAGAGAGGGGAGAAGAGAGAAGGAAGGAGAGCGCCTGCCGGG
ATGGCTGAGCTGCCTCGGCGAGCAGCCTTGGGGTTGCACGCTCTTGTGGGAGATGCTGCTGTTGCTTCCAGGTCGGCAAGAGCGGTTCTA
ACACCATCGCCTCTCACCCTCTTTCCTGTAAATCCCTAGAGAAACGTCCCTGGCCTCTCCGCCGCGACATTCCCAGCCTGCATCCCCCTA
CAGCCTAGGCGGCGCGCTCCCGCACGCTGGAGCGCCGGTCGCCAGCAGGACGCCCTCTCCCGCGCCGACTCGCCCCTCTCTGCCCTGCTG
CTGCTGCTCCTCTGACACCTCCGCCCCCACCATCTCCAGCTCGGAGAGACGCCACCCAGCCGCGGCCCGCACTCGCGGCCCGGGGTCACG
CGCGGAAGAGGGGCGCTAGTCCGGACCCCGCCTTCGGTAGGGGGCGTCCTGGAGCGGAGAGTGAGGCGAATGGTATATGAGTGTGCGGGT
AGCCCACCCTGAAGCCCGAGCTTCTCATTTGAGCCATCCCCGCCTAGCCCCACTCGGGCCAGCGCCTGGCGAGCGAGCCCATCTGTGGCT
TCCGCGGCCGCCTCCTCCTTGCATCCTTGCACCTCCTCGTCGACCCCTCCCTCCCGGGACCTGCATCCTGCTCCACCAATCAGAGCCCGA
CTGCCTCTTCCCACGTGACCCCGGGCGGGCTGAGGACCTGCTGCTTCCCAAACGCCAGAGGGATGCGGGCGGCAGAGCTCGAGAGGCGGC
TGCCGGGCTGCGGGGCGCCTTGACTCTCCCTCCACCCTGCCTCCTCGGGCTCCACTCGTCTGCCCCTGGACTCCCGTCTCCTCCTGTCCT
CCGGCTTCCCAGAGCTCCCTCCTTATGGCAGCAGCTTCCCGCGTCTCCGGCGCAGCTTCTCAGCGGACGACCCTCTCGCTCCGGGGCTGA
GCCCAGTCCCTGGATGTTGCTGAAACTCTCGAGATCATGCGCGGGTTTGGCTGCTGCTTCCCCGCCGGGTGCCACTGCCACCGCCGCCGC
CTCTGCTGCCGCCGTCCGCGGGATGCTCAGTAGCCCGCTGCCCGGCCCCCGCGATCCTGTGTTCCTCGGAAGCCGTTTGCTGCTGCAGAG
TTGCACGAACTAGTCATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTTGCTGGCTGCTGCTGCTG
CCCGTCATGCTACTCATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAACGCCCACCGGCTGGAAT
TGCTCTGGTTATGATGACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAATGTTTAAGAATTGGAGAC
ACTGTGACTTGCGTCTGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCTACCAGAATGAGTGTTAC
CTGCGACAGGCTGCATGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAGGATCAGGATCTGGAGAT
GGAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGA
CAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCA
GGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTC
TGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGT
GCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCG
GCAGCCACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGG
TGTTGAGTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCA
GCACTGTGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACT
CCCTGAGGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTG
CTGGGGGATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGC
CGCCCCTACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACC
GTCACTCAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGC
TGTGCTGTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCT
GGTTCTCCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTT
CCCCGACCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGT
TGGGGCTGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCT
TTGGGCACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAG
AAAAGGCAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTG
CAGCCCATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTT
TCAGAACTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTG
AGAGAACGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTC

>91490_91490_1_TMEFF2-CHMP1A_TMEFF2_chr2_193044394_ENST00000272771_CHMP1A_chr16_89713739_ENST00000253475_length(amino acids)=314AA_BP=151
MHELVMVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGD
TVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGGDQEYGPGDQSPGQGPEHHGPAEGLLSDG
QVRAAGAEPGRPYIGDGGLHELGHHPDHAAGAGGQPHHADRRGEWPGGAGPAQPAARGRLCRGRELCAQPGGPAVTEVGRLEELAVPRRC

--------------------------------------------------------------
>91490_91490_2_TMEFF2-CHMP1A_TMEFF2_chr2_193044394_ENST00000392314_CHMP1A_chr16_89713739_ENST00000253475_length(transcript)=2798nt_BP=831nt
AGAGCTCGAGAGGCGGCTGCCGGGCTGCGGGGCGCCTTGACTCTCCCTCCACCCTGCCTCCTCGGGCTCCACTCGTCTGCCCCTGGACTC
CCGTCTCCTCCTGTCCTCCGGCTTCCCAGAGCTCCCTCCTTATGGCAGCAGCTTCCCGCGTCTCCGGCGCAGCTTCTCAGCGGACGACCC
TCTCGCTCCGGGGCTGAGCCCAGTCCCTGGATGTTGCTGAAACTCTCGAGATCATGCGCGGGTTTGGCTGCTGCTTCCCCGCCGGGTGCC
ACTGCCACCGCCGCCGCCTCTGCTGCCGCCGTCCGCGGGATGCTCAGTAGCCCGCTGCCCGGCCCCCGCGATCCTGTGTTCCTCGGAAGC
CGTTTGCTGCTGCAGAGTTGCACGAACTAGTCATGGTGCTGTGGGAGTCCCCGCGGCAGTGCAGCAGCTGGACACTTTGCGAGGGCTTTT
GCTGGCTGCTGCTGCTGCCCGTCATGCTACTCATCGTAGCCCGCCCGGTGAAGCTCGCTGCTTTCCCTACCTCCTTAAGTGACTGCCAAA
CGCCCACCGGCTGGAATTGCTCTGGTTATGATGACAGAGAAAATGATCTCTTCCTCTGTGACACCAACACCTGTAAATTTGATGGGGAAT
GTTTAAGAATTGGAGACACTGTGACTTGCGTCTGTCAGTTCAAGTGCAACAATGACTATGTGCCTGTGTGTGGCTCCAATGGGGAGAGCT
ACCAGAATGAGTGTTACCTGCGACAGGCTGCATGCAAACAGCAGAGTGAGATACTTGTGGTGTCAGAAGGATCATGTGCCACAGATGCAG
GATCAGGATCTGGAGATGGAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAG
GTCTCCTCAGTGATGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACC
ACCCTGACCACGCCGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAG
CTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAG
CCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACC
CCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCG
GTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCC
CTGTGGACTTTCACCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGC
CCTGTTGCCAAACAACTCCCTGAGGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCA
CCACAGGTCTATGTGTGCTGGGGGATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCC
AGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAG
TCCATGGGGACAGAACCGTCACTCAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTG
CCTTTGGCCACATGTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTC
CTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGT
AAACAACTGGGTGCCTTCCCCGACCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTC
TTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTG
GGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTT
TGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCA
GTCCTGCCCACCCCGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCAC
TGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAA
AATCAACCCTGGTGTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAG
GTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCACTGAGGAGAGGGGCCCATTCACCTTTCTCCTAGAATGCTGTTGTAAATAAACAAATGG

>91490_91490_2_TMEFF2-CHMP1A_TMEFF2_chr2_193044394_ENST00000392314_CHMP1A_chr16_89713739_ENST00000253475_length(amino acids)=314AA_BP=151
MHELVMVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYDDRENDLFLCDTNTCKFDGECLRIGD
TVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAACKQQSEILVVSEGSCATDAGSGSGDGGDQEYGPGDQSPGQGPEHHGPAEGLLSDG
QVRAAGAEPGRPYIGDGGLHELGHHPDHAAGAGGQPHHADRRGEWPGGAGPAQPAARGRLCRGRELCAQPGGPAVTEVGRLEELAVPRRC

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Fusion Gene PPI Analysis for TMEFF2-CHMP1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEFF2-CHMP1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEFF2-CHMP1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource