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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM107-FXR2 (FusionGDB2 ID:91523)

Fusion Gene Summary for TMEM107-FXR2

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM107-FXR2
	Fusion gene ID: 91523
		Hgene	Tgene
	Gene symbol	TMEM107	FXR2
	Gene ID	84314	9513
	Gene name	transmembrane protein 107	FMR1 autosomal homolog 2
	Synonyms	GRVS638\|JBTS29\|MKS13\|PRO1268	FMR1L2\|FXR2P
	Cytomap	17p13.1	17p13.1
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 107	fragile X mental retardation syndrome-related protein 2fragile X mental retardation, autosomal homolog 2fragile X-mental retardation 1-like 2
	Modification date	20200313	20200327
	UniProtAcc	.	P51116
	Ensembl transtripts involved in fusion gene	ENST00000316425, ENST00000431792, ENST00000437139, ENST00000449985, ENST00000532998, ENST00000533070,	ENST00000573057, ENST00000250113,
Fusion gene scores	* DoF score	6 X 4 X 3=72	10 X 9 X 6=540
	# samples	7	11
	** MAII score	log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/540*10)=-2.29545588352617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM107 [Title/Abstract] AND FXR2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM107(8079518)-FXR2(7509467), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMEM107	GO:0060271	cilium assembly	26518474

Fusion gene breakpoints across TMEM107 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FXR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-FP-7829-01A	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-

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Fusion Gene ORF analysis for TMEM107-FXR2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000316425	ENST00000573057	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
5CDS-intron	ENST00000431792	ENST00000573057	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
5CDS-intron	ENST00000437139	ENST00000573057	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
5CDS-intron	ENST00000449985	ENST00000573057	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
5CDS-intron	ENST00000532998	ENST00000573057	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
5CDS-intron	ENST00000533070	ENST00000573057	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
In-frame	ENST00000316425	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
In-frame	ENST00000431792	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
In-frame	ENST00000437139	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
In-frame	ENST00000449985	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
In-frame	ENST00000532998	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-
In-frame	ENST00000533070	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000449985	TMEM107	chr17	8079518	-	ENST00000250113	FXR2	chr17	7509467	-	2715	174	36	2114	692
ENST00000532998	TMEM107	chr17	8079518	-	ENST00000250113	FXR2	chr17	7509467	-	2715	174	36	2114	692
ENST00000437139	TMEM107	chr17	8079518	-	ENST00000250113	FXR2	chr17	7509467	-	2716	175	37	2115	692
ENST00000533070	TMEM107	chr17	8079518	-	ENST00000250113	FXR2	chr17	7509467	-	2730	189	51	2129	692
ENST00000316425	TMEM107	chr17	8079518	-	ENST00000250113	FXR2	chr17	7509467	-	2741	200	62	2140	692
ENST00000431792	TMEM107	chr17	8079518	-	ENST00000250113	FXR2	chr17	7509467	-	2658	117	15	2057	680

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000449985	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-	0.005448241	0.9945517
ENST00000532998	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-	0.005448241	0.9945517
ENST00000437139	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-	0.005556184	0.99444383
ENST00000533070	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-	0.005498928	0.9945011
ENST00000316425	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-	0.005503302	0.99449664
ENST00000431792	ENST00000250113	TMEM107	chr17	8079518	-	FXR2	chr17	7509467	-	0.005226927	0.9947731

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Fusion Genomic Features for TMEM107-FXR2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM107-FXR2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:8079518/chr17:7509467)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FXR2 P51116
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: RNA-binding protein.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000316425

7_27

147.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000437139

7_27

141.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000533070

7_27

140.0

Transmembrane

Helical

Tgene

FXR2

chr17:8079518

chr17:7509467

ENST00000250113

414_418

674.0

Compositional bias

Note=Poly-Ser

Tgene

FXR2

chr17:8079518

chr17:7509467

ENST00000250113

544_552

674.0

Compositional bias

Note=Poly-Arg

Tgene

FXR2

chr17:8079518

chr17:7509467

ENST00000250113

584_594

674.0

Compositional bias

Note=Poly-Arg

Tgene

FXR2

chr17:8079518

chr17:7509467

ENST00000250113

232_261

674.0

Domain

KH 1

Tgene

FXR2

chr17:8079518

chr17:7509467

ENST00000250113

295_324

674.0

Domain

KH 2

Tgene

FXR2

chr17:8079518

chr17:7509467

ENST00000250113

73_125

674.0

Domain

Agenet-like 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000316425

113_133

147.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000316425

53_73

147.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000316425

83_103

147.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000437139

113_133

141.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000437139

53_73

141.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000437139

83_103

141.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000533070

113_133

140.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000533070

53_73

140.0

Transmembrane

Helical

Hgene

TMEM107

chr17:8079518

chr17:7509467

ENST00000533070

83_103

140.0

Transmembrane

Helical

Tgene

FXR2

chr17:8079518

chr17:7509467

ENST00000250113

14_60

674.0

Domain

Agenet-like 1

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Fusion Gene Sequence for TMEM107-FXR2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91523_91523_1_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000316425_FXR2_chr17_7509467_ENST00000250113_length(transcript)=2741nt_BP=200nt
GAGCGGGCGGGAAGGAGGCGTTCGTCTAGATTTGTCGGCTTGCGGGGAGACTTCAGGAGTCGCTGTCTCTGAACTTCCAGCCTCAGAGAC
CGCCGCCCTTGTCCCCGAGGGCCATGGGCCGGGTCTCAGGGCTTGTGCCCTCTCGCTTCCTGACGCTCCTGGCGCATCTGGTGGTCGTCA
TCACCTTATTCTGGTCCCGGGGCTTTGTGAAGGATGTCCATGAAGACTCTGTCACCATCTTCTTTGAAAACAACTGGCAGAGTGAGAGAC
AAATTCCTTTTGGGGATGTCCGGCTACCACCTCCAGCTGACTATAATAAGGAGATCACAGAAGGGGATGAAGTGGAGGTTTATTCTCGAG
CCAATGAACAGGAACCTTGTGGCTGGTGGCTGGCCCGGGTGCGGATGATGAAGGGAGATTTCTATGTCATTGAATATGCTGCCTGTGATG
CCACCTACAATGAAATTGTTACCCTGGAGCGACTTCGGCCAGTTAATCCCAATCCCCTTGCAACCAAAGGCAGCTTCTTCAAGGTTACCA
TGGCTGTGCCCGAGGATCTGAGAGAAGCCTGCTCCAATGAAAACGTCCATAAAGAGTTCAAGAAAGCCCTGGGAGCCAACTGCATCTTTC
TCAACATCACAAACAGTGAGCTCTTCATTCTGTCAACCACAGAAGCCCCTGTGAAGCGAGCATCTCTGCTGGGTGATATGCATTTCCGAA
GCCTGCGCACCAAACTGCTACTTATGTCCCGCAATGAAGAAGCTACCAAGCACCTAGAGACAAGCAAGCAGTTGGCAGCAGCCTTCCAAG
AGGAGTTCACAGTGCGAGAGGACCTGATGGGACTGGCAATTGGGACTCACGGTGCCAACATCCAGCAGGCCCGAAAAGTACCTGGGGTGA
CCGCCATTGAGTTGGGTGAAGAGACCTGCACTTTCCGCATCTATGGGGAGACTCCCGAGGCTTGCCGACAGGCCCGAAGCTACCTTGAGT
TTTCTGAGGACTCAGTGCAAGTGCCCAGGAACCTGGTTGGCAAAGTGATTGGAAAGAACGGGAAAGTGATCCAGGAGATTGTGGATAAAT
CTGGTGTGGTGAGGGTTCGAGTGGAAGGTGATAATGACAAGAAGAACCCCAGGGAGGAGGGAATGGTTCCCTTCATTTTTGTTGGCACCC
GAGAGAACATCAGCAATGCCCAGGCTTTGCTGGAGTATCACCTCTCCTACCTGCAGGAGGTAGAGCAGCTTCGCTTGGAGAGGCTACAAA
TTGATGAGCAGCTTCGGCAGATTGGGCTGGGCTTTCGCCCTCCTGGGAGTGGGCGGGGCAGCGGTGGCAGCGACAAGGCTGGATATAGCA
CTGATGAGAGCTCCTCCTCCTCCCTCCATGCGACTCGAACCTATGGGGGCAGCTATGGGGGCCGTGGCCGTGGCCGGAGGACAGGCGGTC
CTGCCTATGGCCCCAGCTCAGATGTGTCTACAGCTTCAGAGACTGAGTCAGAGAAGAGAGAGGAGCCCAACCGAGCTGGGCCTGGCGACA
GGGATCCCCCAACCCGAGGGGAAGAAAGCCGGAGGCGGCCGACTGGGGGCCGGGGTAGGGGACCCCCACCTGCCCCCCGGCCCACTTCGA
GATACAATTCTTCATCTATTAGCTCAGTGCTGAAGGATCCAGACAGTAATCCCTACAGCCTATTGGACACGTCTGAACCAGAGCCCCCGG
TTGATTCAGAACCTGGGGAACCCCCCCCAGCAAGTGCCAGGCGCCGCCGCTCCCGCCGCCGCCGCACTGATGAAGACAGGACCGTCATGG
ATGGAGGCCTGGAATCAGATGGGCCCAACATGACAGAGAATGGCCTGGAAGATGAATCAAGACCTCAACGTCGTAATCGCAGCCGCCGCC
GCCGTAACCGTGGTAATCGGACTGATGGCTCTATCAGTGGAGACCGCCAGCCAGTGACTGTGGCTGACTATATCTCACGAGCAGAGTCTC
AGAGCCGCCAGAGGCCACCCCTGGAACGCACTAAACCCTCAGAAGACTCTCTTTCAGGACAGAAGGGTGACTCTGTCAGCAAGCTTCCTA
AGGGCCCCTCGGAGAATGGGGAGCTCTCCGCCCCCTTGGAGTTGGGTAGTATGGTGAATGGGGTTTCATAAAACCTCCAACCTGCACCCC
TCCCTTCTCCATCTCGCTTGCTGCCCAACACCATGGCCCTCACAGGCCCAACTGACCTGCGCTGGAGCTGCTCTTATCTAGGGGGGAGGG
GGGTGGCACAGCAGCTTGGGTACCCCCCAACCTCCAGGAGCTAGTGGAGGGGTGTGTAACAGGGTCATACCCCCTCCCTCTTGTCCACCC
TACCCCCAGGGTAAGGGGAGCCTCTCTCCTTCCCCATCAGACTGGATGTGCCTTTATCCTCTAATGCCCCAATCTCTCTCTGAACACCCC
CATTCTCCACCTGTTGGTGGGGGGTGCTCCTCGACCCACCCAGATTTGACCGTTCAGGGGGCCTCCCCTGCTATCCCTCCTCCCATCCTG
TACCCCCCATTTCTGGGGCCTCATCACTGTGGAAGACGGGGATAGTAAGAGATAAGTGGGTGGGAGGCACGGGGAAGGTTTTGGAGTAGA
ACCAGGGGTGTGTATGAAGGGGGGTGACAAGGTCCCCCTGGGGAGGGGACCAACCTTGTCTGGTGGATGAGAAGGCGTATTTATTTTTCA

>91523_91523_1_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000316425_FXR2_chr17_7509467_ENST00000250113_length(amino acids)=692AA_BP=1
MSLNFQPQRPPPLSPRAMGRVSGLVPSRFLTLLAHLVVVITLFWSRGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITE
GDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFK
KALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANI
QQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEG
MVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGG
RGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSL
LDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTV

--------------------------------------------------------------
>91523_91523_2_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000431792_FXR2_chr17_7509467_ENST00000250113_length(transcript)=2658nt_BP=117nt
CAGAGACCGCCGCCCTTGTCCCCGAGGGCCATGGGCCGGGTCTCAGGGCTTGTGCCCTCTCGCTTCCTGACGCTCCTGGCGCATCTGGTG
GTCGTCATCACCTTATTCTGGTCCCGGGGCTTTGTGAAGGATGTCCATGAAGACTCTGTCACCATCTTCTTTGAAAACAACTGGCAGAGT
GAGAGACAAATTCCTTTTGGGGATGTCCGGCTACCACCTCCAGCTGACTATAATAAGGAGATCACAGAAGGGGATGAAGTGGAGGTTTAT
TCTCGAGCCAATGAACAGGAACCTTGTGGCTGGTGGCTGGCCCGGGTGCGGATGATGAAGGGAGATTTCTATGTCATTGAATATGCTGCC
TGTGATGCCACCTACAATGAAATTGTTACCCTGGAGCGACTTCGGCCAGTTAATCCCAATCCCCTTGCAACCAAAGGCAGCTTCTTCAAG
GTTACCATGGCTGTGCCCGAGGATCTGAGAGAAGCCTGCTCCAATGAAAACGTCCATAAAGAGTTCAAGAAAGCCCTGGGAGCCAACTGC
ATCTTTCTCAACATCACAAACAGTGAGCTCTTCATTCTGTCAACCACAGAAGCCCCTGTGAAGCGAGCATCTCTGCTGGGTGATATGCAT
TTCCGAAGCCTGCGCACCAAACTGCTACTTATGTCCCGCAATGAAGAAGCTACCAAGCACCTAGAGACAAGCAAGCAGTTGGCAGCAGCC
TTCCAAGAGGAGTTCACAGTGCGAGAGGACCTGATGGGACTGGCAATTGGGACTCACGGTGCCAACATCCAGCAGGCCCGAAAAGTACCT
GGGGTGACCGCCATTGAGTTGGGTGAAGAGACCTGCACTTTCCGCATCTATGGGGAGACTCCCGAGGCTTGCCGACAGGCCCGAAGCTAC
CTTGAGTTTTCTGAGGACTCAGTGCAAGTGCCCAGGAACCTGGTTGGCAAAGTGATTGGAAAGAACGGGAAAGTGATCCAGGAGATTGTG
GATAAATCTGGTGTGGTGAGGGTTCGAGTGGAAGGTGATAATGACAAGAAGAACCCCAGGGAGGAGGGAATGGTTCCCTTCATTTTTGTT
GGCACCCGAGAGAACATCAGCAATGCCCAGGCTTTGCTGGAGTATCACCTCTCCTACCTGCAGGAGGTAGAGCAGCTTCGCTTGGAGAGG
CTACAAATTGATGAGCAGCTTCGGCAGATTGGGCTGGGCTTTCGCCCTCCTGGGAGTGGGCGGGGCAGCGGTGGCAGCGACAAGGCTGGA
TATAGCACTGATGAGAGCTCCTCCTCCTCCCTCCATGCGACTCGAACCTATGGGGGCAGCTATGGGGGCCGTGGCCGTGGCCGGAGGACA
GGCGGTCCTGCCTATGGCCCCAGCTCAGATGTGTCTACAGCTTCAGAGACTGAGTCAGAGAAGAGAGAGGAGCCCAACCGAGCTGGGCCT
GGCGACAGGGATCCCCCAACCCGAGGGGAAGAAAGCCGGAGGCGGCCGACTGGGGGCCGGGGTAGGGGACCCCCACCTGCCCCCCGGCCC
ACTTCGAGATACAATTCTTCATCTATTAGCTCAGTGCTGAAGGATCCAGACAGTAATCCCTACAGCCTATTGGACACGTCTGAACCAGAG
CCCCCGGTTGATTCAGAACCTGGGGAACCCCCCCCAGCAAGTGCCAGGCGCCGCCGCTCCCGCCGCCGCCGCACTGATGAAGACAGGACC
GTCATGGATGGAGGCCTGGAATCAGATGGGCCCAACATGACAGAGAATGGCCTGGAAGATGAATCAAGACCTCAACGTCGTAATCGCAGC
CGCCGCCGCCGTAACCGTGGTAATCGGACTGATGGCTCTATCAGTGGAGACCGCCAGCCAGTGACTGTGGCTGACTATATCTCACGAGCA
GAGTCTCAGAGCCGCCAGAGGCCACCCCTGGAACGCACTAAACCCTCAGAAGACTCTCTTTCAGGACAGAAGGGTGACTCTGTCAGCAAG
CTTCCTAAGGGCCCCTCGGAGAATGGGGAGCTCTCCGCCCCCTTGGAGTTGGGTAGTATGGTGAATGGGGTTTCATAAAACCTCCAACCT
GCACCCCTCCCTTCTCCATCTCGCTTGCTGCCCAACACCATGGCCCTCACAGGCCCAACTGACCTGCGCTGGAGCTGCTCTTATCTAGGG
GGGAGGGGGGTGGCACAGCAGCTTGGGTACCCCCCAACCTCCAGGAGCTAGTGGAGGGGTGTGTAACAGGGTCATACCCCCTCCCTCTTG
TCCACCCTACCCCCAGGGTAAGGGGAGCCTCTCTCCTTCCCCATCAGACTGGATGTGCCTTTATCCTCTAATGCCCCAATCTCTCTCTGA
ACACCCCCATTCTCCACCTGTTGGTGGGGGGTGCTCCTCGACCCACCCAGATTTGACCGTTCAGGGGGCCTCCCCTGCTATCCCTCCTCC
CATCCTGTACCCCCCATTTCTGGGGCCTCATCACTGTGGAAGACGGGGATAGTAAGAGATAAGTGGGTGGGAGGCACGGGGAAGGTTTTG
GAGTAGAACCAGGGGTGTGTATGAAGGGGGGTGACAAGGTCCCCCTGGGGAGGGGACCAACCTTGTCTGGTGGATGAGAAGGCGTATTTA

>91523_91523_2_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000431792_FXR2_chr17_7509467_ENST00000250113_length(amino acids)=680AA_BP=34
MSPRAMGRVSGLVPSRFLTLLAHLVVVITLFWSRGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITEGDEVEVYSRANE
QEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNI
TNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANIQQARKVPGVTAI
ELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTREN
ISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRGRRTGGPAY
GPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDS
EPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSR

--------------------------------------------------------------
>91523_91523_3_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000437139_FXR2_chr17_7509467_ENST00000250113_length(transcript)=2716nt_BP=175nt
CTAGATTTGTCGGCTTGCGGGGAGACTTCAGGAGTCGCTGTCTCTGAACTTCCAGCCTCAGAGACCGCCGCCCTTGTCCCCGAGGGCCAT
GGGCCGGGTCTCAGGGCTTGTGCCCTCTCGCTTCCTGACGCTCCTGGCGCATCTGGTGGTCGTCATCACCTTATTCTGGTCCCGGGGCTT
TGTGAAGGATGTCCATGAAGACTCTGTCACCATCTTCTTTGAAAACAACTGGCAGAGTGAGAGACAAATTCCTTTTGGGGATGTCCGGCT
ACCACCTCCAGCTGACTATAATAAGGAGATCACAGAAGGGGATGAAGTGGAGGTTTATTCTCGAGCCAATGAACAGGAACCTTGTGGCTG
GTGGCTGGCCCGGGTGCGGATGATGAAGGGAGATTTCTATGTCATTGAATATGCTGCCTGTGATGCCACCTACAATGAAATTGTTACCCT
GGAGCGACTTCGGCCAGTTAATCCCAATCCCCTTGCAACCAAAGGCAGCTTCTTCAAGGTTACCATGGCTGTGCCCGAGGATCTGAGAGA
AGCCTGCTCCAATGAAAACGTCCATAAAGAGTTCAAGAAAGCCCTGGGAGCCAACTGCATCTTTCTCAACATCACAAACAGTGAGCTCTT
CATTCTGTCAACCACAGAAGCCCCTGTGAAGCGAGCATCTCTGCTGGGTGATATGCATTTCCGAAGCCTGCGCACCAAACTGCTACTTAT
GTCCCGCAATGAAGAAGCTACCAAGCACCTAGAGACAAGCAAGCAGTTGGCAGCAGCCTTCCAAGAGGAGTTCACAGTGCGAGAGGACCT
GATGGGACTGGCAATTGGGACTCACGGTGCCAACATCCAGCAGGCCCGAAAAGTACCTGGGGTGACCGCCATTGAGTTGGGTGAAGAGAC
CTGCACTTTCCGCATCTATGGGGAGACTCCCGAGGCTTGCCGACAGGCCCGAAGCTACCTTGAGTTTTCTGAGGACTCAGTGCAAGTGCC
CAGGAACCTGGTTGGCAAAGTGATTGGAAAGAACGGGAAAGTGATCCAGGAGATTGTGGATAAATCTGGTGTGGTGAGGGTTCGAGTGGA
AGGTGATAATGACAAGAAGAACCCCAGGGAGGAGGGAATGGTTCCCTTCATTTTTGTTGGCACCCGAGAGAACATCAGCAATGCCCAGGC
TTTGCTGGAGTATCACCTCTCCTACCTGCAGGAGGTAGAGCAGCTTCGCTTGGAGAGGCTACAAATTGATGAGCAGCTTCGGCAGATTGG
GCTGGGCTTTCGCCCTCCTGGGAGTGGGCGGGGCAGCGGTGGCAGCGACAAGGCTGGATATAGCACTGATGAGAGCTCCTCCTCCTCCCT
CCATGCGACTCGAACCTATGGGGGCAGCTATGGGGGCCGTGGCCGTGGCCGGAGGACAGGCGGTCCTGCCTATGGCCCCAGCTCAGATGT
GTCTACAGCTTCAGAGACTGAGTCAGAGAAGAGAGAGGAGCCCAACCGAGCTGGGCCTGGCGACAGGGATCCCCCAACCCGAGGGGAAGA
AAGCCGGAGGCGGCCGACTGGGGGCCGGGGTAGGGGACCCCCACCTGCCCCCCGGCCCACTTCGAGATACAATTCTTCATCTATTAGCTC
AGTGCTGAAGGATCCAGACAGTAATCCCTACAGCCTATTGGACACGTCTGAACCAGAGCCCCCGGTTGATTCAGAACCTGGGGAACCCCC
CCCAGCAAGTGCCAGGCGCCGCCGCTCCCGCCGCCGCCGCACTGATGAAGACAGGACCGTCATGGATGGAGGCCTGGAATCAGATGGGCC
CAACATGACAGAGAATGGCCTGGAAGATGAATCAAGACCTCAACGTCGTAATCGCAGCCGCCGCCGCCGTAACCGTGGTAATCGGACTGA
TGGCTCTATCAGTGGAGACCGCCAGCCAGTGACTGTGGCTGACTATATCTCACGAGCAGAGTCTCAGAGCCGCCAGAGGCCACCCCTGGA
ACGCACTAAACCCTCAGAAGACTCTCTTTCAGGACAGAAGGGTGACTCTGTCAGCAAGCTTCCTAAGGGCCCCTCGGAGAATGGGGAGCT
CTCCGCCCCCTTGGAGTTGGGTAGTATGGTGAATGGGGTTTCATAAAACCTCCAACCTGCACCCCTCCCTTCTCCATCTCGCTTGCTGCC
CAACACCATGGCCCTCACAGGCCCAACTGACCTGCGCTGGAGCTGCTCTTATCTAGGGGGGAGGGGGGTGGCACAGCAGCTTGGGTACCC
CCCAACCTCCAGGAGCTAGTGGAGGGGTGTGTAACAGGGTCATACCCCCTCCCTCTTGTCCACCCTACCCCCAGGGTAAGGGGAGCCTCT
CTCCTTCCCCATCAGACTGGATGTGCCTTTATCCTCTAATGCCCCAATCTCTCTCTGAACACCCCCATTCTCCACCTGTTGGTGGGGGGT
GCTCCTCGACCCACCCAGATTTGACCGTTCAGGGGGCCTCCCCTGCTATCCCTCCTCCCATCCTGTACCCCCCATTTCTGGGGCCTCATC
ACTGTGGAAGACGGGGATAGTAAGAGATAAGTGGGTGGGAGGCACGGGGAAGGTTTTGGAGTAGAACCAGGGGTGTGTATGAAGGGGGGT
GACAAGGTCCCCCTGGGGAGGGGACCAACCTTGTCTGGTGGATGAGAAGGCGTATTTATTTTTCACTGTACAGTATTTAAAAAGAGAATA

>91523_91523_3_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000437139_FXR2_chr17_7509467_ENST00000250113_length(amino acids)=692AA_BP=1
MSLNFQPQRPPPLSPRAMGRVSGLVPSRFLTLLAHLVVVITLFWSRGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITE
GDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFK
KALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANI
QQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEG
MVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGG
RGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSL
LDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTV

--------------------------------------------------------------
>91523_91523_4_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000449985_FXR2_chr17_7509467_ENST00000250113_length(transcript)=2715nt_BP=174nt
TAGATTTGTCGGCTTGCGGGGAGACTTCAGGAGTCGCTGTCTCTGAACTTCCAGCCTCAGAGACCGCCGCCCTTGTCCCCGAGGGCCATG
GGCCGGGTCTCAGGGCTTGTGCCCTCTCGCTTCCTGACGCTCCTGGCGCATCTGGTGGTCGTCATCACCTTATTCTGGTCCCGGGGCTTT
GTGAAGGATGTCCATGAAGACTCTGTCACCATCTTCTTTGAAAACAACTGGCAGAGTGAGAGACAAATTCCTTTTGGGGATGTCCGGCTA
CCACCTCCAGCTGACTATAATAAGGAGATCACAGAAGGGGATGAAGTGGAGGTTTATTCTCGAGCCAATGAACAGGAACCTTGTGGCTGG
TGGCTGGCCCGGGTGCGGATGATGAAGGGAGATTTCTATGTCATTGAATATGCTGCCTGTGATGCCACCTACAATGAAATTGTTACCCTG
GAGCGACTTCGGCCAGTTAATCCCAATCCCCTTGCAACCAAAGGCAGCTTCTTCAAGGTTACCATGGCTGTGCCCGAGGATCTGAGAGAA
GCCTGCTCCAATGAAAACGTCCATAAAGAGTTCAAGAAAGCCCTGGGAGCCAACTGCATCTTTCTCAACATCACAAACAGTGAGCTCTTC
ATTCTGTCAACCACAGAAGCCCCTGTGAAGCGAGCATCTCTGCTGGGTGATATGCATTTCCGAAGCCTGCGCACCAAACTGCTACTTATG
TCCCGCAATGAAGAAGCTACCAAGCACCTAGAGACAAGCAAGCAGTTGGCAGCAGCCTTCCAAGAGGAGTTCACAGTGCGAGAGGACCTG
ATGGGACTGGCAATTGGGACTCACGGTGCCAACATCCAGCAGGCCCGAAAAGTACCTGGGGTGACCGCCATTGAGTTGGGTGAAGAGACC
TGCACTTTCCGCATCTATGGGGAGACTCCCGAGGCTTGCCGACAGGCCCGAAGCTACCTTGAGTTTTCTGAGGACTCAGTGCAAGTGCCC
AGGAACCTGGTTGGCAAAGTGATTGGAAAGAACGGGAAAGTGATCCAGGAGATTGTGGATAAATCTGGTGTGGTGAGGGTTCGAGTGGAA
GGTGATAATGACAAGAAGAACCCCAGGGAGGAGGGAATGGTTCCCTTCATTTTTGTTGGCACCCGAGAGAACATCAGCAATGCCCAGGCT
TTGCTGGAGTATCACCTCTCCTACCTGCAGGAGGTAGAGCAGCTTCGCTTGGAGAGGCTACAAATTGATGAGCAGCTTCGGCAGATTGGG
CTGGGCTTTCGCCCTCCTGGGAGTGGGCGGGGCAGCGGTGGCAGCGACAAGGCTGGATATAGCACTGATGAGAGCTCCTCCTCCTCCCTC
CATGCGACTCGAACCTATGGGGGCAGCTATGGGGGCCGTGGCCGTGGCCGGAGGACAGGCGGTCCTGCCTATGGCCCCAGCTCAGATGTG
TCTACAGCTTCAGAGACTGAGTCAGAGAAGAGAGAGGAGCCCAACCGAGCTGGGCCTGGCGACAGGGATCCCCCAACCCGAGGGGAAGAA
AGCCGGAGGCGGCCGACTGGGGGCCGGGGTAGGGGACCCCCACCTGCCCCCCGGCCCACTTCGAGATACAATTCTTCATCTATTAGCTCA
GTGCTGAAGGATCCAGACAGTAATCCCTACAGCCTATTGGACACGTCTGAACCAGAGCCCCCGGTTGATTCAGAACCTGGGGAACCCCCC
CCAGCAAGTGCCAGGCGCCGCCGCTCCCGCCGCCGCCGCACTGATGAAGACAGGACCGTCATGGATGGAGGCCTGGAATCAGATGGGCCC
AACATGACAGAGAATGGCCTGGAAGATGAATCAAGACCTCAACGTCGTAATCGCAGCCGCCGCCGCCGTAACCGTGGTAATCGGACTGAT
GGCTCTATCAGTGGAGACCGCCAGCCAGTGACTGTGGCTGACTATATCTCACGAGCAGAGTCTCAGAGCCGCCAGAGGCCACCCCTGGAA
CGCACTAAACCCTCAGAAGACTCTCTTTCAGGACAGAAGGGTGACTCTGTCAGCAAGCTTCCTAAGGGCCCCTCGGAGAATGGGGAGCTC
TCCGCCCCCTTGGAGTTGGGTAGTATGGTGAATGGGGTTTCATAAAACCTCCAACCTGCACCCCTCCCTTCTCCATCTCGCTTGCTGCCC
AACACCATGGCCCTCACAGGCCCAACTGACCTGCGCTGGAGCTGCTCTTATCTAGGGGGGAGGGGGGTGGCACAGCAGCTTGGGTACCCC
CCAACCTCCAGGAGCTAGTGGAGGGGTGTGTAACAGGGTCATACCCCCTCCCTCTTGTCCACCCTACCCCCAGGGTAAGGGGAGCCTCTC
TCCTTCCCCATCAGACTGGATGTGCCTTTATCCTCTAATGCCCCAATCTCTCTCTGAACACCCCCATTCTCCACCTGTTGGTGGGGGGTG
CTCCTCGACCCACCCAGATTTGACCGTTCAGGGGGCCTCCCCTGCTATCCCTCCTCCCATCCTGTACCCCCCATTTCTGGGGCCTCATCA
CTGTGGAAGACGGGGATAGTAAGAGATAAGTGGGTGGGAGGCACGGGGAAGGTTTTGGAGTAGAACCAGGGGTGTGTATGAAGGGGGGTG
ACAAGGTCCCCCTGGGGAGGGGACCAACCTTGTCTGGTGGATGAGAAGGCGTATTTATTTTTCACTGTACAGTATTTAAAAAGAGAATAA

>91523_91523_4_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000449985_FXR2_chr17_7509467_ENST00000250113_length(amino acids)=692AA_BP=1
MSLNFQPQRPPPLSPRAMGRVSGLVPSRFLTLLAHLVVVITLFWSRGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITE
GDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFK
KALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANI
QQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEG
MVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGG
RGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSL
LDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTV

--------------------------------------------------------------
>91523_91523_5_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000532998_FXR2_chr17_7509467_ENST00000250113_length(transcript)=2715nt_BP=174nt
TAGATTTGTCGGCTTGCGGGGAGACTTCAGGAGTCGCTGTCTCTGAACTTCCAGCCTCAGAGACCGCCGCCCTTGTCCCCGAGGGCCATG
GGCCGGGTCTCAGGGCTTGTGCCCTCTCGCTTCCTGACGCTCCTGGCGCATCTGGTGGTCGTCATCACCTTATTCTGGTCCCGGGGCTTT
GTGAAGGATGTCCATGAAGACTCTGTCACCATCTTCTTTGAAAACAACTGGCAGAGTGAGAGACAAATTCCTTTTGGGGATGTCCGGCTA
CCACCTCCAGCTGACTATAATAAGGAGATCACAGAAGGGGATGAAGTGGAGGTTTATTCTCGAGCCAATGAACAGGAACCTTGTGGCTGG
TGGCTGGCCCGGGTGCGGATGATGAAGGGAGATTTCTATGTCATTGAATATGCTGCCTGTGATGCCACCTACAATGAAATTGTTACCCTG
GAGCGACTTCGGCCAGTTAATCCCAATCCCCTTGCAACCAAAGGCAGCTTCTTCAAGGTTACCATGGCTGTGCCCGAGGATCTGAGAGAA
GCCTGCTCCAATGAAAACGTCCATAAAGAGTTCAAGAAAGCCCTGGGAGCCAACTGCATCTTTCTCAACATCACAAACAGTGAGCTCTTC
ATTCTGTCAACCACAGAAGCCCCTGTGAAGCGAGCATCTCTGCTGGGTGATATGCATTTCCGAAGCCTGCGCACCAAACTGCTACTTATG
TCCCGCAATGAAGAAGCTACCAAGCACCTAGAGACAAGCAAGCAGTTGGCAGCAGCCTTCCAAGAGGAGTTCACAGTGCGAGAGGACCTG
ATGGGACTGGCAATTGGGACTCACGGTGCCAACATCCAGCAGGCCCGAAAAGTACCTGGGGTGACCGCCATTGAGTTGGGTGAAGAGACC
TGCACTTTCCGCATCTATGGGGAGACTCCCGAGGCTTGCCGACAGGCCCGAAGCTACCTTGAGTTTTCTGAGGACTCAGTGCAAGTGCCC
AGGAACCTGGTTGGCAAAGTGATTGGAAAGAACGGGAAAGTGATCCAGGAGATTGTGGATAAATCTGGTGTGGTGAGGGTTCGAGTGGAA
GGTGATAATGACAAGAAGAACCCCAGGGAGGAGGGAATGGTTCCCTTCATTTTTGTTGGCACCCGAGAGAACATCAGCAATGCCCAGGCT
TTGCTGGAGTATCACCTCTCCTACCTGCAGGAGGTAGAGCAGCTTCGCTTGGAGAGGCTACAAATTGATGAGCAGCTTCGGCAGATTGGG
CTGGGCTTTCGCCCTCCTGGGAGTGGGCGGGGCAGCGGTGGCAGCGACAAGGCTGGATATAGCACTGATGAGAGCTCCTCCTCCTCCCTC
CATGCGACTCGAACCTATGGGGGCAGCTATGGGGGCCGTGGCCGTGGCCGGAGGACAGGCGGTCCTGCCTATGGCCCCAGCTCAGATGTG
TCTACAGCTTCAGAGACTGAGTCAGAGAAGAGAGAGGAGCCCAACCGAGCTGGGCCTGGCGACAGGGATCCCCCAACCCGAGGGGAAGAA
AGCCGGAGGCGGCCGACTGGGGGCCGGGGTAGGGGACCCCCACCTGCCCCCCGGCCCACTTCGAGATACAATTCTTCATCTATTAGCTCA
GTGCTGAAGGATCCAGACAGTAATCCCTACAGCCTATTGGACACGTCTGAACCAGAGCCCCCGGTTGATTCAGAACCTGGGGAACCCCCC
CCAGCAAGTGCCAGGCGCCGCCGCTCCCGCCGCCGCCGCACTGATGAAGACAGGACCGTCATGGATGGAGGCCTGGAATCAGATGGGCCC
AACATGACAGAGAATGGCCTGGAAGATGAATCAAGACCTCAACGTCGTAATCGCAGCCGCCGCCGCCGTAACCGTGGTAATCGGACTGAT
GGCTCTATCAGTGGAGACCGCCAGCCAGTGACTGTGGCTGACTATATCTCACGAGCAGAGTCTCAGAGCCGCCAGAGGCCACCCCTGGAA
CGCACTAAACCCTCAGAAGACTCTCTTTCAGGACAGAAGGGTGACTCTGTCAGCAAGCTTCCTAAGGGCCCCTCGGAGAATGGGGAGCTC
TCCGCCCCCTTGGAGTTGGGTAGTATGGTGAATGGGGTTTCATAAAACCTCCAACCTGCACCCCTCCCTTCTCCATCTCGCTTGCTGCCC
AACACCATGGCCCTCACAGGCCCAACTGACCTGCGCTGGAGCTGCTCTTATCTAGGGGGGAGGGGGGTGGCACAGCAGCTTGGGTACCCC
CCAACCTCCAGGAGCTAGTGGAGGGGTGTGTAACAGGGTCATACCCCCTCCCTCTTGTCCACCCTACCCCCAGGGTAAGGGGAGCCTCTC
TCCTTCCCCATCAGACTGGATGTGCCTTTATCCTCTAATGCCCCAATCTCTCTCTGAACACCCCCATTCTCCACCTGTTGGTGGGGGGTG
CTCCTCGACCCACCCAGATTTGACCGTTCAGGGGGCCTCCCCTGCTATCCCTCCTCCCATCCTGTACCCCCCATTTCTGGGGCCTCATCA
CTGTGGAAGACGGGGATAGTAAGAGATAAGTGGGTGGGAGGCACGGGGAAGGTTTTGGAGTAGAACCAGGGGTGTGTATGAAGGGGGGTG
ACAAGGTCCCCCTGGGGAGGGGACCAACCTTGTCTGGTGGATGAGAAGGCGTATTTATTTTTCACTGTACAGTATTTAAAAAGAGAATAA

>91523_91523_5_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000532998_FXR2_chr17_7509467_ENST00000250113_length(amino acids)=692AA_BP=1
MSLNFQPQRPPPLSPRAMGRVSGLVPSRFLTLLAHLVVVITLFWSRGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITE
GDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFK
KALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANI
QQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEG
MVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGG
RGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSL
LDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTV

--------------------------------------------------------------
>91523_91523_6_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000533070_FXR2_chr17_7509467_ENST00000250113_length(transcript)=2730nt_BP=189nt
AAGGAGGCGTTCGTCTAGATTTGTCGGCTTGCGGGGAGACTTCAGGAGTCGCTGTCTCTGAACTTCCAGCCTCAGAGACCGCCGCCCTTG
TCCCCGAGGGCCATGGGCCGGGTCTCAGGGCTTGTGCCCTCTCGCTTCCTGACGCTCCTGGCGCATCTGGTGGTCGTCATCACCTTATTC
TGGTCCCGGGGCTTTGTGAAGGATGTCCATGAAGACTCTGTCACCATCTTCTTTGAAAACAACTGGCAGAGTGAGAGACAAATTCCTTTT
GGGGATGTCCGGCTACCACCTCCAGCTGACTATAATAAGGAGATCACAGAAGGGGATGAAGTGGAGGTTTATTCTCGAGCCAATGAACAG
GAACCTTGTGGCTGGTGGCTGGCCCGGGTGCGGATGATGAAGGGAGATTTCTATGTCATTGAATATGCTGCCTGTGATGCCACCTACAAT
GAAATTGTTACCCTGGAGCGACTTCGGCCAGTTAATCCCAATCCCCTTGCAACCAAAGGCAGCTTCTTCAAGGTTACCATGGCTGTGCCC
GAGGATCTGAGAGAAGCCTGCTCCAATGAAAACGTCCATAAAGAGTTCAAGAAAGCCCTGGGAGCCAACTGCATCTTTCTCAACATCACA
AACAGTGAGCTCTTCATTCTGTCAACCACAGAAGCCCCTGTGAAGCGAGCATCTCTGCTGGGTGATATGCATTTCCGAAGCCTGCGCACC
AAACTGCTACTTATGTCCCGCAATGAAGAAGCTACCAAGCACCTAGAGACAAGCAAGCAGTTGGCAGCAGCCTTCCAAGAGGAGTTCACA
GTGCGAGAGGACCTGATGGGACTGGCAATTGGGACTCACGGTGCCAACATCCAGCAGGCCCGAAAAGTACCTGGGGTGACCGCCATTGAG
TTGGGTGAAGAGACCTGCACTTTCCGCATCTATGGGGAGACTCCCGAGGCTTGCCGACAGGCCCGAAGCTACCTTGAGTTTTCTGAGGAC
TCAGTGCAAGTGCCCAGGAACCTGGTTGGCAAAGTGATTGGAAAGAACGGGAAAGTGATCCAGGAGATTGTGGATAAATCTGGTGTGGTG
AGGGTTCGAGTGGAAGGTGATAATGACAAGAAGAACCCCAGGGAGGAGGGAATGGTTCCCTTCATTTTTGTTGGCACCCGAGAGAACATC
AGCAATGCCCAGGCTTTGCTGGAGTATCACCTCTCCTACCTGCAGGAGGTAGAGCAGCTTCGCTTGGAGAGGCTACAAATTGATGAGCAG
CTTCGGCAGATTGGGCTGGGCTTTCGCCCTCCTGGGAGTGGGCGGGGCAGCGGTGGCAGCGACAAGGCTGGATATAGCACTGATGAGAGC
TCCTCCTCCTCCCTCCATGCGACTCGAACCTATGGGGGCAGCTATGGGGGCCGTGGCCGTGGCCGGAGGACAGGCGGTCCTGCCTATGGC
CCCAGCTCAGATGTGTCTACAGCTTCAGAGACTGAGTCAGAGAAGAGAGAGGAGCCCAACCGAGCTGGGCCTGGCGACAGGGATCCCCCA
ACCCGAGGGGAAGAAAGCCGGAGGCGGCCGACTGGGGGCCGGGGTAGGGGACCCCCACCTGCCCCCCGGCCCACTTCGAGATACAATTCT
TCATCTATTAGCTCAGTGCTGAAGGATCCAGACAGTAATCCCTACAGCCTATTGGACACGTCTGAACCAGAGCCCCCGGTTGATTCAGAA
CCTGGGGAACCCCCCCCAGCAAGTGCCAGGCGCCGCCGCTCCCGCCGCCGCCGCACTGATGAAGACAGGACCGTCATGGATGGAGGCCTG
GAATCAGATGGGCCCAACATGACAGAGAATGGCCTGGAAGATGAATCAAGACCTCAACGTCGTAATCGCAGCCGCCGCCGCCGTAACCGT
GGTAATCGGACTGATGGCTCTATCAGTGGAGACCGCCAGCCAGTGACTGTGGCTGACTATATCTCACGAGCAGAGTCTCAGAGCCGCCAG
AGGCCACCCCTGGAACGCACTAAACCCTCAGAAGACTCTCTTTCAGGACAGAAGGGTGACTCTGTCAGCAAGCTTCCTAAGGGCCCCTCG
GAGAATGGGGAGCTCTCCGCCCCCTTGGAGTTGGGTAGTATGGTGAATGGGGTTTCATAAAACCTCCAACCTGCACCCCTCCCTTCTCCA
TCTCGCTTGCTGCCCAACACCATGGCCCTCACAGGCCCAACTGACCTGCGCTGGAGCTGCTCTTATCTAGGGGGGAGGGGGGTGGCACAG
CAGCTTGGGTACCCCCCAACCTCCAGGAGCTAGTGGAGGGGTGTGTAACAGGGTCATACCCCCTCCCTCTTGTCCACCCTACCCCCAGGG
TAAGGGGAGCCTCTCTCCTTCCCCATCAGACTGGATGTGCCTTTATCCTCTAATGCCCCAATCTCTCTCTGAACACCCCCATTCTCCACC
TGTTGGTGGGGGGTGCTCCTCGACCCACCCAGATTTGACCGTTCAGGGGGCCTCCCCTGCTATCCCTCCTCCCATCCTGTACCCCCCATT
TCTGGGGCCTCATCACTGTGGAAGACGGGGATAGTAAGAGATAAGTGGGTGGGAGGCACGGGGAAGGTTTTGGAGTAGAACCAGGGGTGT
GTATGAAGGGGGGTGACAAGGTCCCCCTGGGGAGGGGACCAACCTTGTCTGGTGGATGAGAAGGCGTATTTATTTTTCACTGTACAGTAT

>91523_91523_6_TMEM107-FXR2_TMEM107_chr17_8079518_ENST00000533070_FXR2_chr17_7509467_ENST00000250113_length(amino acids)=692AA_BP=1
MSLNFQPQRPPPLSPRAMGRVSGLVPSRFLTLLAHLVVVITLFWSRGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPPPADYNKEITE
GDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFK
KALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLMGLAIGTHGANI
QQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEG
MVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLHATRTYGGSYGG
RGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEESRRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSL
LDTSEPEPPVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDGSISGDRQPVTV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TMEM107-FXR2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM107-FXR2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TMEM107-FXR2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source