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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BCAP31-SYNJ2BP (FusionGDB2 ID:9157)

Fusion Gene Summary for BCAP31-SYNJ2BP

Fusion gene summary

Fusion gene information	Fusion gene name: BCAP31-SYNJ2BP
	Fusion gene ID: 9157
		Hgene	Tgene
	Gene symbol	BCAP31	SYNJ2BP
	Gene ID	10134	55333
	Gene name	B cell receptor associated protein 31	synaptojanin 2 binding protein
	Synonyms	6C6-AG\|BAP31\|CDM\|DDCH\|DXS1357E	ARIP2\|OMP25
	Cytomap	Xq28	14q24.2
	Type of gene	protein-coding	protein-coding
	Description	B-cell receptor-associated protein 316C6-AG tumor-associated antigenBCR-associated protein Bap31p28 Bap31	synaptojanin-2-binding proteinactivin receptor interacting protein 5mitochondrial outer membrane protein 25
	Modification date	20200313	20200313
	UniProtAcc	P51572	.
	Ensembl transtripts involved in fusion gene	ENST00000345046, ENST00000441714, ENST00000458587, ENST00000468947,	ENST00000554216, ENST00000256366,
Fusion gene scores	* DoF score	6 X 8 X 4=192	2 X 2 X 2=8
	# samples	9	2
	** MAII score	log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: BCAP31 [Title/Abstract] AND SYNJ2BP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BCAP31(152969414)-SYNJ2BP(70842488), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BCAP31	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	18555783
Tgene	SYNJ2BP	GO:0070373	negative regulation of ERK1 and ERK2 cascade	24025447

Fusion gene breakpoints across BCAP31 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SYNJ2BP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-OL-A97C-01A	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-

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Fusion Gene ORF analysis for BCAP31-SYNJ2BP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000345046	ENST00000554216	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-
5CDS-5UTR	ENST00000441714	ENST00000554216	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-
5CDS-5UTR	ENST00000458587	ENST00000554216	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-
Frame-shift	ENST00000345046	ENST00000256366	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-
In-frame	ENST00000441714	ENST00000256366	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-
In-frame	ENST00000458587	ENST00000256366	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-
intron-3CDS	ENST00000468947	ENST00000256366	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-
intron-5UTR	ENST00000468947	ENST00000554216	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000441714	BCAP31	chrX	152969414	-	ENST00000256366	SYNJ2BP	chr14	70842488	-	2501	704	227	940	237
ENST00000458587	BCAP31	chrX	152969414	-	ENST00000256366	SYNJ2BP	chr14	70842488	-	2905	1108	391	1344	317

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000441714	ENST00000256366	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-	0.003549461	0.99645054
ENST00000458587	ENST00000256366	BCAP31	chrX	152969414	-	SYNJ2BP	chr14	70842488	-	0.002710785	0.9972892

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Fusion Genomic Features for BCAP31-SYNJ2BP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BCAP31-SYNJ2BP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:152969414/chr14:70842488)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BCAP31 P51572	.
FUNCTION: Functions as a chaperone protein (PubMed:9396746, PubMed:18287538). Is one of the most abundant endoplasmic reticulum (ER) proteins (PubMed:9396746, PubMed:18287538). Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD) (PubMed:9396746, PubMed:18287538). Also serves as a cargo receptor for the export of transmembrane proteins (By similarity). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by stimulating the translocation of NDUFS4 and NDUFB11 from the cytosol to the mitochondria via interaction with TOMM40 (PubMed:31206022). In response to ER stress, delocalizes from the ER-mitochondria contact sites and binds BCL2 (PubMed:31206022). May be involved in CASP8-mediated apoptosis (PubMed:10958671). {ECO:0000250\|UniProtKB:Q61335, ECO:0000269\|PubMed:10958671, ECO:0000269\|PubMed:18287538, ECO:0000269\|PubMed:31206022, ECO:0000269\|PubMed:9396746}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000345046

28_43

159

247.0

Topological domain

Cytoplasmic

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000345046

2_6

159

247.0

Topological domain

Lumenal

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000345046

65_102

159

247.0

Topological domain

Lumenal

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000441714

28_43

159

247.0

Topological domain

Cytoplasmic

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000441714

2_6

159

247.0

Topological domain

Lumenal

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000441714

65_102

159

247.0

Topological domain

Lumenal

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000458587

28_43

226

314.0

Topological domain

Cytoplasmic

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000458587

2_6

226

314.0

Topological domain

Lumenal

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000458587

65_102

226

314.0

Topological domain

Lumenal

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000345046

103_123

159

247.0

Transmembrane

Helical

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000345046

44_64

159

247.0

Transmembrane

Helical

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000345046

7_27

159

247.0

Transmembrane

Helical

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000441714

103_123

159

247.0

Transmembrane

Helical

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000441714

44_64

159

247.0

Transmembrane

Helical

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000441714

7_27

159

247.0

Transmembrane

Helical

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000458587

103_123

226

314.0

Transmembrane

Helical

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000458587

44_64

226

314.0

Transmembrane

Helical

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000458587

7_27

226

314.0

Transmembrane

Helical

Tgene

SYNJ2BP

chrX:152969414

chr14:70842488

ENST00000256366

139_145

146.0

Topological domain

Mitochondrial intermembrane

Tgene

SYNJ2BP

chrX:152969414

chr14:70842488

ENST00000256366

118_138

146.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000345046

165_237

159

247.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000441714

165_237

159

247.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000458587

165_237

226

314.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000345046

243_246

159

247.0

Motif

Note=Di-lysine motif

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000441714

243_246

159

247.0

Motif

Note=Di-lysine motif

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000458587

243_246

226

314.0

Motif

Note=Di-lysine motif

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000345046

124_246

159

247.0

Topological domain

Cytoplasmic

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000441714

124_246

159

247.0

Topological domain

Cytoplasmic

Hgene

BCAP31

chrX:152969414

chr14:70842488

ENST00000458587

124_246

226

314.0

Topological domain

Cytoplasmic

Tgene

SYNJ2BP

chrX:152969414

chr14:70842488

ENST00000256366

13_100

146.0

Domain

PDZ

Tgene

SYNJ2BP

chrX:152969414

chr14:70842488

ENST00000256366

1_117

146.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for BCAP31-SYNJ2BP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>9157_9157_1_BCAP31-SYNJ2BP_BCAP31_chrX_152969414_ENST00000441714_SYNJ2BP_chr14_70842488_ENST00000256366_length(transcript)=2501nt_BP=704nt
GAGAGTTCTGTTGCTGCGGCGGGGCCTGCACGTTGACTGTGGGAAACTCGGTGAGCGGGCTCCGCGCGCCGGGCTGGGCTCCGGGACCGC
GGAGGCTCCCCGGCCCATCGACGAGGGAGAGAGGCGAGCGGCGCGGGGAGGCCCGGGGGCCGGGGAATCTCGGGGCCCGCAGCCTACCTG
CGTGAAACAAGCTCACATCTTCCTGTGGGAAACCTTCTAGCAACAGGATGAGTCTGCAGTGGACTGCAGTTGCCACCTTCCTCTATGCGG
AGGTCTTTGTTGTGTTGCTTCTCTGCATTCCCTTCATTTCTCCTAAAAGATGGCAGAAGATTTTCAAGTCCCGGCTGGTGGAGTTGTTAG
TGTCCTATGGCAACACCTTCTTTGTGGTTCTCATTGTCATCCTTGTGCTGTTGGTCATCGATGCCGTGCGCGAAATTCGGAAGTATGATG
ATGTGACGGAAAAGGTGAACCTCCAGAACAATCCCGGGGCCATGGAGCACTTCCACATGAAGCTTTTCCGTGCCCAGAGGAATCTCTACA
TTGCTGGCTTTTCCTTGCTGCTGTCCTTCCTGCTTAGACGCCTGGTGACTCTCATTTCGCAGCAGGCCACGCTGCTGGCCTCCAATGAAG
CCTTTAAAAAGCAGGCGGAGAGTGCTAGTGAGGCGGCCAAGAAGTACATGGAGGAGAATGACCAGCTCAAGAAGGTAAATGGCCAAGACC
TAAAGAACCTGCTGCACCAGGATGCTGTAGACCTCTTTCGTAATGCAGGCTATGCTGTGTCTCTGAGAGTGCAGCACAGGTTACAGGTGC
AGAATGGACCTATAGGACATCGAGGTGAAGGGGACCCAAGTGGTATTCCCATATTTATGGTGCTGGTGCCAGTGTTTGCCCTCACCATGG
TAGCAGCCTGGGCTTTCATGAGATACCGGCAACAACTTTGAAAAACTTGCTCTCTTTCAATACTCCCAATGAAGATACATTTCACTCACC
CTCCACCCCTGCTATTCTGCCATGTCTTTCCCTCTCTCTGCATAGCCAGATTTGAAGTGACTGATACCCACCCCAAACCTTGCTGTTCAC
AGTCTCCAATTCTTCATATTCTAATGGGAAAGTAAAGGTATTGTTTGAAGGAAAACTGAAGAAAAGACTTGGCTTAGAACAAATGAGGAG
TTATATATTTTACTAGGACTTTTGATAGAAATTCAGCTACAACCCAAAGAGAGAAAGATTGAGTCTTCCTGTCACCATAGGCAATACCTT
TTTTCTTAGCTGGCATGCCATAAAGGCCAGCTATGTGATATTAGAGGAAGAAAGGATTTTTCTTTTTAATGATCTTCCTTGGGAAATTAT
TGTGGCCTTTATTTAATTTCTAACTACGTACCTGGGTGCCTATATCGACAAAGAGTGAGAAGAGCATTTTTACTTTTTTAAAAAAGCAAA
TACATATATACACATACGTATGCAAATATTATAGTATAATAGTGATCCCTATGGAGAATTAAAGGTGAGAAAGCTACTTTGTGGTGTCTA
GGTTTCTGATAAAAGGGATGATCTTAACTGAAGAATTTAAAGAGATACTTAAACAGAGCAAATGTAGTAGGAACAAGGGAGTGAGCCTTA
TAAGAGGACGTTCAGTCTCATTTATTAAAATAATAACTGAGACTGGGAGAGGTGGCTCATGCCTGTAAATCCCAGCACTTTGGTAGCCTG
AAGTGGGAGATTGCTTGAGTCCAGGAGACCAGCCTGGGCAACATAGCAAAACCTCATCTCTATTTAAAAAAAAAATAGAAAAAAATGTAA
TAACTGAAGCAACTAATTAAAAATCTTAGAAGAACAATATTTATTCTTATAACAGCCAACTATGGTGAGTTATTATAAGGTAAATTGCCA
TAATCCAGCGCTGCTCACATCTAAAAAACTTTGAGGTGTAAAGGTAAATCGTACCAATCTCTGGGCTGCCCTAGTGACTTTTTTGATACC
TCAGAGTCCTATTGAAGAACCAGGTGGAATGATTGTGGTAAGGGCTATAGTGCTGGAGCCAAACACCCCAGCAAGAAAACTCTAAAAGGA
CAAAAGATAAGGTAGTGCCTCCAAGGTGGCACCTGAACCCTCTCAGGCTACTTTTTGGTTTCTACTAACAAACCTGAGGGAAGGAACTGC
CTCCCTGGCAGGATGGGCATCAAATCAACTCTGGCTTCAGATTTAGTTAAAATGAGGCCGGGTGCAGCGGCTCACACCTGTCATCTCAGC
ACTTTGGGAGGCCGAGGCAGGCAGATCACAAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATGTCTACTGAAAATA
CAAAAATTACCTGGACATGGTGGCGCGTTCCTGTAATTCCAGCTACTCAGGAGGCTGAGGCAGGAGAACTGTTTGAACCAGGACCTGGGA

>9157_9157_1_BCAP31-SYNJ2BP_BCAP31_chrX_152969414_ENST00000441714_SYNJ2BP_chr14_70842488_ENST00000256366_length(amino acids)=237AA_BP=159
MSLQWTAVATFLYAEVFVVLLLCIPFISPKRWQKIFKSRLVELLVSYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAME
HFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKVNGQDLKNLLHQDAVDLFRNA

--------------------------------------------------------------
>9157_9157_2_BCAP31-SYNJ2BP_BCAP31_chrX_152969414_ENST00000458587_SYNJ2BP_chr14_70842488_ENST00000256366_length(transcript)=2905nt_BP=1108nt
CTCCGGGACGGTGTGCCAGGCCGGGGCCAAGTCGGAGGCCCCTCGCTCTGGGTGGGCGCTGGGGCCCGCGAGGGCTACTGTAAGGACCCC
TGGCTTCTGAGGATACTGCGTCTAGAACTTTCTCCGTATGGGGCCTTGAGGTGCTTGGTCGAGACCTGCCTTTGCGCTTGGTCCCGAATC
CTGCCCTCTAGGAGTCGCTCTTGCGGGCCTCCAGCCCACCGGAGGCGAAGCGGCCCCGGGCGGAAGGCCGCTGGATCCTCGAGGGAGGTG
CCGGTTTCTCTCCGCGGGCGCCGTGGGGACGGTGGGAGGCGGGGGCGTCGGCAGCGCTTGGACTAGGTGCGGCCTTGGGCCTGCCTGGTA
GCGGGGATTTGGGCCCGCAGAGCGCCCGCCTCTGCGGCTGAGTTCTGCCTGGCGGGGAAGGGAGCGCCCGATGGGTGCCGAGGCGTCCTC
CTCTTGGTGCCCTGGCACTGCTCTTCCCGAAGAACGCCTTTCAGTTAAACGGGCGTCGGAAATCTCGGGCTTCCTGGGGCAGGGATCGTC
GGGAGAGGCCGCTCTGGACGTGTTGACACACGTGCTGGAGGGGGCAGGAAACAAGCTCACATCTTCCTGTGGGAAACCTTCTAGCAACAG
GATGAGTCTGCAGTGGACTGCAGTTGCCACCTTCCTCTATGCGGAGGTCTTTGTTGTGTTGCTTCTCTGCATTCCCTTCATTTCTCCTAA
AAGATGGCAGAAGATTTTCAAGTCCCGGCTGGTGGAGTTGTTAGTGTCCTATGGCAACACCTTCTTTGTGGTTCTCATTGTCATCCTTGT
GCTGTTGGTCATCGATGCCGTGCGCGAAATTCGGAAGTATGATGATGTGACGGAAAAGGTGAACCTCCAGAACAATCCCGGGGCCATGGA
GCACTTCCACATGAAGCTTTTCCGTGCCCAGAGGAATCTCTACATTGCTGGCTTTTCCTTGCTGCTGTCCTTCCTGCTTAGACGCCTGGT
GACTCTCATTTCGCAGCAGGCCACGCTGCTGGCCTCCAATGAAGCCTTTAAAAAGCAGGCGGAGAGTGCTAGTGAGGCGGCCAAGAAGTA
CATGGAGGAGAATGACCAGCTCAAGAAGGTAAATGGCCAAGACCTAAAGAACCTGCTGCACCAGGATGCTGTAGACCTCTTTCGTAATGC
AGGCTATGCTGTGTCTCTGAGAGTGCAGCACAGGTTACAGGTGCAGAATGGACCTATAGGACATCGAGGTGAAGGGGACCCAAGTGGTAT
TCCCATATTTATGGTGCTGGTGCCAGTGTTTGCCCTCACCATGGTAGCAGCCTGGGCTTTCATGAGATACCGGCAACAACTTTGAAAAAC
TTGCTCTCTTTCAATACTCCCAATGAAGATACATTTCACTCACCCTCCACCCCTGCTATTCTGCCATGTCTTTCCCTCTCTCTGCATAGC
CAGATTTGAAGTGACTGATACCCACCCCAAACCTTGCTGTTCACAGTCTCCAATTCTTCATATTCTAATGGGAAAGTAAAGGTATTGTTT
GAAGGAAAACTGAAGAAAAGACTTGGCTTAGAACAAATGAGGAGTTATATATTTTACTAGGACTTTTGATAGAAATTCAGCTACAACCCA
AAGAGAGAAAGATTGAGTCTTCCTGTCACCATAGGCAATACCTTTTTTCTTAGCTGGCATGCCATAAAGGCCAGCTATGTGATATTAGAG
GAAGAAAGGATTTTTCTTTTTAATGATCTTCCTTGGGAAATTATTGTGGCCTTTATTTAATTTCTAACTACGTACCTGGGTGCCTATATC
GACAAAGAGTGAGAAGAGCATTTTTACTTTTTTAAAAAAGCAAATACATATATACACATACGTATGCAAATATTATAGTATAATAGTGAT
CCCTATGGAGAATTAAAGGTGAGAAAGCTACTTTGTGGTGTCTAGGTTTCTGATAAAAGGGATGATCTTAACTGAAGAATTTAAAGAGAT
ACTTAAACAGAGCAAATGTAGTAGGAACAAGGGAGTGAGCCTTATAAGAGGACGTTCAGTCTCATTTATTAAAATAATAACTGAGACTGG
GAGAGGTGGCTCATGCCTGTAAATCCCAGCACTTTGGTAGCCTGAAGTGGGAGATTGCTTGAGTCCAGGAGACCAGCCTGGGCAACATAG
CAAAACCTCATCTCTATTTAAAAAAAAAATAGAAAAAAATGTAATAACTGAAGCAACTAATTAAAAATCTTAGAAGAACAATATTTATTC
TTATAACAGCCAACTATGGTGAGTTATTATAAGGTAAATTGCCATAATCCAGCGCTGCTCACATCTAAAAAACTTTGAGGTGTAAAGGTA
AATCGTACCAATCTCTGGGCTGCCCTAGTGACTTTTTTGATACCTCAGAGTCCTATTGAAGAACCAGGTGGAATGATTGTGGTAAGGGCT
ATAGTGCTGGAGCCAAACACCCCAGCAAGAAAACTCTAAAAGGACAAAAGATAAGGTAGTGCCTCCAAGGTGGCACCTGAACCCTCTCAG
GCTACTTTTTGGTTTCTACTAACAAACCTGAGGGAAGGAACTGCCTCCCTGGCAGGATGGGCATCAAATCAACTCTGGCTTCAGATTTAG
TTAAAATGAGGCCGGGTGCAGCGGCTCACACCTGTCATCTCAGCACTTTGGGAGGCCGAGGCAGGCAGATCACAAGGTCAGGAGTTCAAG
ACCAGCCTGGCCAACATGGTGAAACCCCATGTCTACTGAAAATACAAAAATTACCTGGACATGGTGGCGCGTTCCTGTAATTCCAGCTAC
TCAGGAGGCTGAGGCAGGAGAACTGTTTGAACCAGGACCTGGGAGACGGAGGTTGCAGTGAGCCAAGATCACGCCACTGCACTCCAGCCT

>9157_9157_2_BCAP31-SYNJ2BP_BCAP31_chrX_152969414_ENST00000458587_SYNJ2BP_chr14_70842488_ENST00000256366_length(amino acids)=317AA_BP=239
MRLSSAWRGRERPMGAEASSSWCPGTALPEERLSVKRASEISGFLGQGSSGEAALDVLTHVLEGAGNKLTSSCGKPSSNRMSLQWTAVAT
FLYAEVFVVLLLCIPFISPKRWQKIFKSRLVELLVSYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAMEHFHMKLFRAQ
RNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BCAP31-SYNJ2BP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for BCAP31-SYNJ2BP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for BCAP31-SYNJ2BP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source