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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM120B-GRIP1 (FusionGDB2 ID:91579)

Fusion Gene Summary for TMEM120B-GRIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM120B-GRIP1
Fusion gene ID: 91579
HgeneTgene
Gene symbol

TMEM120B

GRIP1

Gene ID

144404

85329

Gene nametransmembrane protein 120Bgalectin 12
Synonyms-GAL12|GRIP1
Cytomap

12q24.31

11q12.3

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 120Bgalectin-12galectin-related inhibitor of proliferationlectin, galactoside-binding, soluble, 12testicular secretory protein Li 26
Modification date2020031320200313
UniProtAcc.

Q9Y3R0

Ensembl transtripts involved in fusion geneENST00000449592, ENST00000540377, 
ENST00000538055, 
ENST00000542021, 
ENST00000286445, ENST00000359742, 
ENST00000398016, 
Fusion gene scores* DoF score11 X 9 X 9=89125 X 17 X 10=4250
# samples 1327
** MAII scorelog2(13/891*10)=-2.77691380849347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/4250*10)=-3.9764315288616
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM120B [Title/Abstract] AND GRIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM120B(122211419)-GRIP1(66773216), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRIP1

GO:0097193

intrinsic apoptotic signaling pathway

11435439


check buttonFusion gene breakpoints across TMEM120B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A1KW-01ATMEM120Bchr12

122211419

-GRIP1chr12

66773216

-
ChimerDB4SARCTCGA-DX-A1KW-01ATMEM120Bchr12

122211419

+GRIP1chr12

66773216

-


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Fusion Gene ORF analysis for TMEM120B-GRIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000449592ENST00000542021TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
5UTR-3CDSENST00000540377ENST00000286445TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
5UTR-3CDSENST00000540377ENST00000359742TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
5UTR-3CDSENST00000540377ENST00000398016TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
5UTR-intronENST00000540377ENST00000542021TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
In-frameENST00000449592ENST00000286445TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
In-frameENST00000449592ENST00000359742TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
In-frameENST00000449592ENST00000398016TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
intron-3CDSENST00000538055ENST00000286445TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
intron-3CDSENST00000538055ENST00000359742TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
intron-3CDSENST00000538055ENST00000398016TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-
intron-intronENST00000538055ENST00000542021TMEM120Bchr12

122211419

+GRIP1chr12

66773216

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000449592TMEM120Bchr12122211419+ENST00000398016GRIP1chr1266773216-3384873351795586
ENST00000449592TMEM120Bchr12122211419+ENST00000359742GRIP1chr1266773216-3384873351795586
ENST00000449592TMEM120Bchr12122211419+ENST00000286445GRIP1chr1266773216-3339873351750571

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449592ENST00000398016TMEM120Bchr12122211419+GRIP1chr1266773216-0.0005572040.99944276
ENST00000449592ENST00000359742TMEM120Bchr12122211419+GRIP1chr1266773216-0.0005572040.99944276
ENST00000449592ENST00000286445TMEM120Bchr12122211419+GRIP1chr1266773216-0.0004556090.9995443

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Fusion Genomic Features for TMEM120B-GRIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM120B-GRIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:122211419/chr12:66773216)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRIP1

Q9Y3R0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (PubMed:10197531). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). {ECO:0000250|UniProtKB:P97879, ECO:0000269|PubMed:10197531}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM120Bchr12:122211419chr12:66773216ENST00000449592+9121_77257340.0Coiled coilOntology_term=ECO:0000255
HgeneTMEM120Bchr12:122211419chr12:66773216ENST00000449592+912102_124257340.0TransmembraneHelical
HgeneTMEM120Bchr12:122211419chr12:66773216ENST00000449592+912132_152257340.0TransmembraneHelical
HgeneTMEM120Bchr12:122211419chr12:66773216ENST00000449592+912159_179257340.0TransmembraneHelical
HgeneTMEM120Bchr12:122211419chr12:66773216ENST00000449592+912187_207257340.0TransmembraneHelical
TgeneGRIP1chr12:122211419chr12:66773216ENST0000028644518241004_10868211114.0DomainPDZ 7
TgeneGRIP1chr12:122211419chr12:66773216ENST0000035974218251004_10868211129.0DomainPDZ 7
TgeneGRIP1chr12:122211419chr12:66773216ENST0000039801617241004_10867691077.0DomainPDZ 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM120Bchr12:122211419chr12:66773216ENST00000449592+912270_290257340.0TransmembraneHelical
HgeneTMEM120Bchr12:122211419chr12:66773216ENST00000449592+912302_322257340.0TransmembraneHelical
TgeneGRIP1chr12:122211419chr12:66773216ENST000002864451824150_2388211114.0DomainPDZ 2
TgeneGRIP1chr12:122211419chr12:66773216ENST000002864451824252_3368211114.0DomainPDZ 3
TgeneGRIP1chr12:122211419chr12:66773216ENST000002864451824472_5618211114.0DomainPDZ 4
TgeneGRIP1chr12:122211419chr12:66773216ENST00000286445182453_1368211114.0DomainPDZ 1
TgeneGRIP1chr12:122211419chr12:66773216ENST000002864451824573_6588211114.0DomainPDZ 5
TgeneGRIP1chr12:122211419chr12:66773216ENST000002864451824673_7558211114.0DomainPDZ 6
TgeneGRIP1chr12:122211419chr12:66773216ENST000003597421825150_2388211129.0DomainPDZ 2
TgeneGRIP1chr12:122211419chr12:66773216ENST000003597421825252_3368211129.0DomainPDZ 3
TgeneGRIP1chr12:122211419chr12:66773216ENST000003597421825472_5618211129.0DomainPDZ 4
TgeneGRIP1chr12:122211419chr12:66773216ENST00000359742182553_1368211129.0DomainPDZ 1
TgeneGRIP1chr12:122211419chr12:66773216ENST000003597421825573_6588211129.0DomainPDZ 5
TgeneGRIP1chr12:122211419chr12:66773216ENST000003597421825673_7558211129.0DomainPDZ 6
TgeneGRIP1chr12:122211419chr12:66773216ENST000003980161724150_2387691077.0DomainPDZ 2
TgeneGRIP1chr12:122211419chr12:66773216ENST000003980161724252_3367691077.0DomainPDZ 3
TgeneGRIP1chr12:122211419chr12:66773216ENST000003980161724472_5617691077.0DomainPDZ 4
TgeneGRIP1chr12:122211419chr12:66773216ENST00000398016172453_1367691077.0DomainPDZ 1
TgeneGRIP1chr12:122211419chr12:66773216ENST000003980161724573_6587691077.0DomainPDZ 5
TgeneGRIP1chr12:122211419chr12:66773216ENST000003980161724673_7557691077.0DomainPDZ 6


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Fusion Gene Sequence for TMEM120B-GRIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91579_91579_1_TMEM120B-GRIP1_TMEM120B_chr12_122211419_ENST00000449592_GRIP1_chr12_66773216_ENST00000286445_length(transcript)=3339nt_BP=873nt
CCGAGGGCGGTCGGCGAGCGCGCGGGCGTGGGGCGCTGGGGGGCCGGTCGGGCAGCGCTGCGGGAGCAGCCGCCGGCACCGCCGCCTTGC
ACCATCGCATCATGTCCGGGCAGCTGGAGCGTTGCGAGCGCGAATGGCACGAGCTGGAGGGAGAATTTCAAGAACTGCAGGAGACGCACA
GGATCTACAAGCAGAAGCTGGAGGAGCTGGCTGCGCTGCAGACGCTGTGTAGCAGTTCCATCAGTAAGCAGAAGAAGCACCTCAAGGACT
TGAAGCTTACACTCCAGAGGTGCAAACGCCATGCCAGTCGGGAGGAGGCGGAGCTCGTTCAGCAGATGGCAGCGAACATCAAGGAGCGGC
AGGACGTCTTCTTCGACATGGAGGCCTACCTGCCCAAGAAGAACGGGCTCTACTTGAACCTGGTCCTCGGCAATGTGAACGTGACCCTCC
TCAGCAACCAGGCCAAGTTCGCCTACAAGGACGAATATGAGAAGTTCAAGCTCTACCTGACCATCATCCTGCTCCTGGGTGCCGTGGCAT
GTCGATTTGTCCTTCACTACAGGGTGACTGACGAAGTCTTCAACTTCCTGCTGGTGTGGTATTACTGCACCCTGACCATTCGGGAGAGCA
TTCTCATCAGCAACGGCTCAAGAATTAAAGGCTGGTGGGTGTCTCACCACTACGTCTCCACATTCCTGTCCGGAGTGATGCTGACCTGGC
CTAATGGACCCATTTATCAGAAGTTTCGCAACCAGTTCTTAGCATTTTCCATTTTTCAGAGCTGCGTCCAGTTCCTGCAATATTATTACC
AGAGGGGCTGCCTCTACCGGCTGCGGGCCCTGGGGGAGAGGAACCACCTGGATCTCACAGTGGGCACTAGTTTTCAGGCCTCAGGATACA
ATTTCAACACCTATGACTGGAGGAGTCCAAAACAGAGAGGCAGCTTGTCCCCAGTCACTAAGCCTCGAAGCCAGACTTACCCAGATGTGG
GGCTGAGTTATGAAGACTGGGACCGGTCCACAGCCAGTGGTTTTGCAGGGGCTGCCGATAGTGCAGAGACAGAACAAGAGGAGAACTTCT
GGTCTCAAGCGCTGGAGGATTTGGAAACCTGCGGACAGTCAGGAATTCTGAGAGAACTGGAGGCAACAATCATGTCGGGGAGCACGATGA
GTTTGAATCATGAGGCTCCAACACCTCGCAGTCAGCTGGGGCGACAGGCCAGCTTCCAGGAGCGCAGCAGCTCGCGGCCGCACTACAGCC
AAACAACTCGGAGCAACACCCTGCCTTCAGATGTGGGTAGGAAGTCAGTAACCCTGAGAAAAATGAAACAAGAAATAAAGGAGATCATGT
CTCCAACTCCTGTGGAGCTGCACAAGGTGACCTTGTACAAGGACTCTGACATGGAGGACTTTGGGTTCAGTGTAGCAGATGGCTTACTGG
AGAAAGGAGTGTATGTCAAAAATATTCGCCCAGCTGGGCCAGGAGATCTTGGTGGCTTAAAGCCCTATGACAGGCTCTTACAGGTGAATC
ATGTCCGAACCAGAGACTTTGACTGCTGCCTTGTTGTGCCCCTCATAGCAGAATCCGGGAATAAGCTGGACCTGGTTATTAGTAGAAACC
CACTGGCTTCACAGAAGTCTATAGACCAACAGAGTCTACCAGGAGATTGGAGTGAACAGAACAGTGCTTTTTTCCAGCAGCCTAGCCACG
GTGGTAATTTGGAGACACGAGAACCCACTAATACATTATAGCAACGCTTTTTATAAAGCAGGACAAAAGACAATATCTACATGGTGCTAA
AAATCCTTTAAGATTTCTGTGACCTTTGAAGCACAGATAATCAATCAACGTGGCATTAACTGCAAGCACAGGGGTCTTTTAAATCTCTCT
CATGGCTCATGTTCACTTCCCTTTTCAAGTTGAAGAGGTTTCTTTTTTGGTGACCACTATGGTATATGGTGGGCAATGCCCTGCCAGTCC
CAACGGTAGAGAAAAATAGGCCGTCCCCCACAACTCTACAATTAACATCAGAGGAAATTTTTTACAAGTTCATCTTACTATCACTTTTTA
AAAAGAGAAACATCTGTTTGAAAATATTCTCTGTGATGATTTCCTTAATTCACTTTGAAATCAGTTTCTTACTATGAAGTCATTAATGTA
AGAACTTGGCCAACAAAGCTTTTCTTCTCATAGGCTGGCTCTACTAGGGGAACTAGTGTTTGGTAAACTGCTGGGACTACCACAATGGGA
GGGGTACAGGTATAAAATTAAGTTATCTTAAAATGTTTCAGCAATGATGCACGTAGGAGACCATAATAGGTGGTGGTAAATGTTTTGCCC
ACGTATAGGAATGATTTTAACTAAGATGTATGCTATTCCCTATGCAACAAATTATCAAACAGGATATGTCTTGTGACCTGTTTTTTTTTT
AAGGACACATTTTTAATAGCTGAAAATCTCTGATAATGAATTAGAGTGTGTAGTAAACATGAGAATTAGTTATATTATCTTATTTTTAAA
ATTCAAGACTAAGAACTTCAGAGAATGAAGAGTCTATTAAAATGAGGTTCATCTTAATGATAGGCAAACCAAACTCATACTGCTTGACAT
GTTTTGAAAACTGGTAATATTGAGGGTGTACAGCACATGTACTTAAAAATGACACTGGACTATCTTTTGCTCTGAGCCATGCCACTTACC
GAAATTGTAAATACATTTTTCACAAATGCATTGCCAATTATTACCATCCCTCAAAGCAATAAATTGTGACAGTTGCTTTAAATGTTTGTC
AGCAACTGTTTTCATTTGTTCAGATATTTTGAATAGCTACACTAATAACTGTTATTATTTGGTGAACATAAAAAAATAAATAGATCTGTA
TATTGATGGTAGACTCTCCATATTGAAATGATTATTTTCCAAACATTTTCATTTTGGTCAATAATTCAAACTACCACTTAGGCAAAGTAT
TCGAACACTGTGTCCTTTGTTTAAGGAAATATAAAAAAAAAATCACCTTTCTTTTTGTGCAAAAAAAATATTATTTCAATCACATTTCAG
AACCGCCAGGGCAAGAAAGTATAAAGCAGGATCATGTTAAGAAAAAAGAAAAAAAGATCATGAGTCACTTAAATATGTATTTTTATTTGT
AACAAACAAGTATTAAACTGTAAAGTATTTTTGTACAAATTTAATACTTTAATAGCATGGTATTTATCGTCTATGTATGGTTTTGGGGAA
TTCAAAATTGTTCAAATATTTGTATGGAAAAAAATAAAACCCTCTACCAAATGGAATAAACAGTGATTTTAAAAAGCCAAATAAAGAGGA

>91579_91579_1_TMEM120B-GRIP1_TMEM120B_chr12_122211419_ENST00000449592_GRIP1_chr12_66773216_ENST00000286445_length(amino acids)=571AA_BP=279
MGGRSGSAAGAAAGTAALHHRIMSGQLERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLTLQRCKRHA
SREEAELVQQMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDE
VFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALG
ERNHLDLTVGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENFWSQALEDLETCG
QSGILRELEATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVTL
YKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVISRNPLASQKSIDQQS

--------------------------------------------------------------
>91579_91579_2_TMEM120B-GRIP1_TMEM120B_chr12_122211419_ENST00000449592_GRIP1_chr12_66773216_ENST00000359742_length(transcript)=3384nt_BP=873nt
CCGAGGGCGGTCGGCGAGCGCGCGGGCGTGGGGCGCTGGGGGGCCGGTCGGGCAGCGCTGCGGGAGCAGCCGCCGGCACCGCCGCCTTGC
ACCATCGCATCATGTCCGGGCAGCTGGAGCGTTGCGAGCGCGAATGGCACGAGCTGGAGGGAGAATTTCAAGAACTGCAGGAGACGCACA
GGATCTACAAGCAGAAGCTGGAGGAGCTGGCTGCGCTGCAGACGCTGTGTAGCAGTTCCATCAGTAAGCAGAAGAAGCACCTCAAGGACT
TGAAGCTTACACTCCAGAGGTGCAAACGCCATGCCAGTCGGGAGGAGGCGGAGCTCGTTCAGCAGATGGCAGCGAACATCAAGGAGCGGC
AGGACGTCTTCTTCGACATGGAGGCCTACCTGCCCAAGAAGAACGGGCTCTACTTGAACCTGGTCCTCGGCAATGTGAACGTGACCCTCC
TCAGCAACCAGGCCAAGTTCGCCTACAAGGACGAATATGAGAAGTTCAAGCTCTACCTGACCATCATCCTGCTCCTGGGTGCCGTGGCAT
GTCGATTTGTCCTTCACTACAGGGTGACTGACGAAGTCTTCAACTTCCTGCTGGTGTGGTATTACTGCACCCTGACCATTCGGGAGAGCA
TTCTCATCAGCAACGGCTCAAGAATTAAAGGCTGGTGGGTGTCTCACCACTACGTCTCCACATTCCTGTCCGGAGTGATGCTGACCTGGC
CTAATGGACCCATTTATCAGAAGTTTCGCAACCAGTTCTTAGCATTTTCCATTTTTCAGAGCTGCGTCCAGTTCCTGCAATATTATTACC
AGAGGGGCTGCCTCTACCGGCTGCGGGCCCTGGGGGAGAGGAACCACCTGGATCTCACAGTGGGCACTAGTTTTCAGGCCTCAGGATACA
ATTTCAACACCTATGACTGGAGGAGTCCAAAACAGAGAGGCAGCTTGTCCCCAGTCACTAAGCCTCGAAGCCAGACTTACCCAGATGTGG
GGCTGAGTTATGAAGACTGGGACCGGTCCACAGCCAGTGGTTTTGCAGGGGCTGCCGATAGTGCAGAGACAGAACAAGAGGAGAACTTCT
GGTCTCAAGCGCTGGAGGATTTGGAAACCTGCGGACAGTCAGGAATTCTGAGAGAACTGGAGGAGAAAGCTGACAGGCGTGTGTCTTTGA
GAAACATGACTCTCTTGGCAACAATCATGTCGGGGAGCACGATGAGTTTGAATCATGAGGCTCCAACACCTCGCAGTCAGCTGGGGCGAC
AGGCCAGCTTCCAGGAGCGCAGCAGCTCGCGGCCGCACTACAGCCAAACAACTCGGAGCAACACCCTGCCTTCAGATGTGGGTAGGAAGT
CAGTAACCCTGAGAAAAATGAAACAAGAAATAAAGGAGATCATGTCTCCAACTCCTGTGGAGCTGCACAAGGTGACCTTGTACAAGGACT
CTGACATGGAGGACTTTGGGTTCAGTGTAGCAGATGGCTTACTGGAGAAAGGAGTGTATGTCAAAAATATTCGCCCAGCTGGGCCAGGAG
ATCTTGGTGGCTTAAAGCCCTATGACAGGCTCTTACAGGTGAATCATGTCCGAACCAGAGACTTTGACTGCTGCCTTGTTGTGCCCCTCA
TAGCAGAATCCGGGAATAAGCTGGACCTGGTTATTAGTAGAAACCCACTGGCTTCACAGAAGTCTATAGACCAACAGAGTCTACCAGGAG
ATTGGAGTGAACAGAACAGTGCTTTTTTCCAGCAGCCTAGCCACGGTGGTAATTTGGAGACACGAGAACCCACTAATACATTATAGCAAC
GCTTTTTATAAAGCAGGACAAAAGACAATATCTACATGGTGCTAAAAATCCTTTAAGATTTCTGTGACCTTTGAAGCACAGATAATCAAT
CAACGTGGCATTAACTGCAAGCACAGGGGTCTTTTAAATCTCTCTCATGGCTCATGTTCACTTCCCTTTTCAAGTTGAAGAGGTTTCTTT
TTTGGTGACCACTATGGTATATGGTGGGCAATGCCCTGCCAGTCCCAACGGTAGAGAAAAATAGGCCGTCCCCCACAACTCTACAATTAA
CATCAGAGGAAATTTTTTACAAGTTCATCTTACTATCACTTTTTAAAAAGAGAAACATCTGTTTGAAAATATTCTCTGTGATGATTTCCT
TAATTCACTTTGAAATCAGTTTCTTACTATGAAGTCATTAATGTAAGAACTTGGCCAACAAAGCTTTTCTTCTCATAGGCTGGCTCTACT
AGGGGAACTAGTGTTTGGTAAACTGCTGGGACTACCACAATGGGAGGGGTACAGGTATAAAATTAAGTTATCTTAAAATGTTTCAGCAAT
GATGCACGTAGGAGACCATAATAGGTGGTGGTAAATGTTTTGCCCACGTATAGGAATGATTTTAACTAAGATGTATGCTATTCCCTATGC
AACAAATTATCAAACAGGATATGTCTTGTGACCTGTTTTTTTTTTAAGGACACATTTTTAATAGCTGAAAATCTCTGATAATGAATTAGA
GTGTGTAGTAAACATGAGAATTAGTTATATTATCTTATTTTTAAAATTCAAGACTAAGAACTTCAGAGAATGAAGAGTCTATTAAAATGA
GGTTCATCTTAATGATAGGCAAACCAAACTCATACTGCTTGACATGTTTTGAAAACTGGTAATATTGAGGGTGTACAGCACATGTACTTA
AAAATGACACTGGACTATCTTTTGCTCTGAGCCATGCCACTTACCGAAATTGTAAATACATTTTTCACAAATGCATTGCCAATTATTACC
ATCCCTCAAAGCAATAAATTGTGACAGTTGCTTTAAATGTTTGTCAGCAACTGTTTTCATTTGTTCAGATATTTTGAATAGCTACACTAA
TAACTGTTATTATTTGGTGAACATAAAAAAATAAATAGATCTGTATATTGATGGTAGACTCTCCATATTGAAATGATTATTTTCCAAACA
TTTTCATTTTGGTCAATAATTCAAACTACCACTTAGGCAAAGTATTCGAACACTGTGTCCTTTGTTTAAGGAAATATAAAAAAAAAATCA
CCTTTCTTTTTGTGCAAAAAAAATATTATTTCAATCACATTTCAGAACCGCCAGGGCAAGAAAGTATAAAGCAGGATCATGTTAAGAAAA
AAGAAAAAAAGATCATGAGTCACTTAAATATGTATTTTTATTTGTAACAAACAAGTATTAAACTGTAAAGTATTTTTGTACAAATTTAAT
ACTTTAATAGCATGGTATTTATCGTCTATGTATGGTTTTGGGGAATTCAAAATTGTTCAAATATTTGTATGGAAAAAAATAAAACCCTCT

>91579_91579_2_TMEM120B-GRIP1_TMEM120B_chr12_122211419_ENST00000449592_GRIP1_chr12_66773216_ENST00000359742_length(amino acids)=586AA_BP=279
MGGRSGSAAGAAAGTAALHHRIMSGQLERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLTLQRCKRHA
SREEAELVQQMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDE
VFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALG
ERNHLDLTVGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENFWSQALEDLETCG
QSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIK
EIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVI

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>91579_91579_3_TMEM120B-GRIP1_TMEM120B_chr12_122211419_ENST00000449592_GRIP1_chr12_66773216_ENST00000398016_length(transcript)=3384nt_BP=873nt
CCGAGGGCGGTCGGCGAGCGCGCGGGCGTGGGGCGCTGGGGGGCCGGTCGGGCAGCGCTGCGGGAGCAGCCGCCGGCACCGCCGCCTTGC
ACCATCGCATCATGTCCGGGCAGCTGGAGCGTTGCGAGCGCGAATGGCACGAGCTGGAGGGAGAATTTCAAGAACTGCAGGAGACGCACA
GGATCTACAAGCAGAAGCTGGAGGAGCTGGCTGCGCTGCAGACGCTGTGTAGCAGTTCCATCAGTAAGCAGAAGAAGCACCTCAAGGACT
TGAAGCTTACACTCCAGAGGTGCAAACGCCATGCCAGTCGGGAGGAGGCGGAGCTCGTTCAGCAGATGGCAGCGAACATCAAGGAGCGGC
AGGACGTCTTCTTCGACATGGAGGCCTACCTGCCCAAGAAGAACGGGCTCTACTTGAACCTGGTCCTCGGCAATGTGAACGTGACCCTCC
TCAGCAACCAGGCCAAGTTCGCCTACAAGGACGAATATGAGAAGTTCAAGCTCTACCTGACCATCATCCTGCTCCTGGGTGCCGTGGCAT
GTCGATTTGTCCTTCACTACAGGGTGACTGACGAAGTCTTCAACTTCCTGCTGGTGTGGTATTACTGCACCCTGACCATTCGGGAGAGCA
TTCTCATCAGCAACGGCTCAAGAATTAAAGGCTGGTGGGTGTCTCACCACTACGTCTCCACATTCCTGTCCGGAGTGATGCTGACCTGGC
CTAATGGACCCATTTATCAGAAGTTTCGCAACCAGTTCTTAGCATTTTCCATTTTTCAGAGCTGCGTCCAGTTCCTGCAATATTATTACC
AGAGGGGCTGCCTCTACCGGCTGCGGGCCCTGGGGGAGAGGAACCACCTGGATCTCACAGTGGGCACTAGTTTTCAGGCCTCAGGATACA
ATTTCAACACCTATGACTGGAGGAGTCCAAAACAGAGAGGCAGCTTGTCCCCAGTCACTAAGCCTCGAAGCCAGACTTACCCAGATGTGG
GGCTGAGTTATGAAGACTGGGACCGGTCCACAGCCAGTGGTTTTGCAGGGGCTGCCGATAGTGCAGAGACAGAACAAGAGGAGAACTTCT
GGTCTCAAGCGCTGGAGGATTTGGAAACCTGCGGACAGTCAGGAATTCTGAGAGAACTGGAGGAGAAAGCTGACAGGCGTGTGTCTTTGA
GAAACATGACTCTCTTGGCAACAATCATGTCGGGGAGCACGATGAGTTTGAATCATGAGGCTCCAACACCTCGCAGTCAGCTGGGGCGAC
AGGCCAGCTTCCAGGAGCGCAGCAGCTCGCGGCCGCACTACAGCCAAACAACTCGGAGCAACACCCTGCCTTCAGATGTGGGTAGGAAGT
CAGTAACCCTGAGAAAAATGAAACAAGAAATAAAGGAGATCATGTCTCCAACTCCTGTGGAGCTGCACAAGGTGACCTTGTACAAGGACT
CTGACATGGAGGACTTTGGGTTCAGTGTAGCAGATGGCTTACTGGAGAAAGGAGTGTATGTCAAAAATATTCGCCCAGCTGGGCCAGGAG
ATCTTGGTGGCTTAAAGCCCTATGACAGGCTCTTACAGGTGAATCATGTCCGAACCAGAGACTTTGACTGCTGCCTTGTTGTGCCCCTCA
TAGCAGAATCCGGGAATAAGCTGGACCTGGTTATTAGTAGAAACCCACTGGCTTCACAGAAGTCTATAGACCAACAGAGTCTACCAGGAG
ATTGGAGTGAACAGAACAGTGCTTTTTTCCAGCAGCCTAGCCACGGTGGTAATTTGGAGACACGAGAACCCACTAATACATTATAGCAAC
GCTTTTTATAAAGCAGGACAAAAGACAATATCTACATGGTGCTAAAAATCCTTTAAGATTTCTGTGACCTTTGAAGCACAGATAATCAAT
CAACGTGGCATTAACTGCAAGCACAGGGGTCTTTTAAATCTCTCTCATGGCTCATGTTCACTTCCCTTTTCAAGTTGAAGAGGTTTCTTT
TTTGGTGACCACTATGGTATATGGTGGGCAATGCCCTGCCAGTCCCAACGGTAGAGAAAAATAGGCCGTCCCCCACAACTCTACAATTAA
CATCAGAGGAAATTTTTTACAAGTTCATCTTACTATCACTTTTTAAAAAGAGAAACATCTGTTTGAAAATATTCTCTGTGATGATTTCCT
TAATTCACTTTGAAATCAGTTTCTTACTATGAAGTCATTAATGTAAGAACTTGGCCAACAAAGCTTTTCTTCTCATAGGCTGGCTCTACT
AGGGGAACTAGTGTTTGGTAAACTGCTGGGACTACCACAATGGGAGGGGTACAGGTATAAAATTAAGTTATCTTAAAATGTTTCAGCAAT
GATGCACGTAGGAGACCATAATAGGTGGTGGTAAATGTTTTGCCCACGTATAGGAATGATTTTAACTAAGATGTATGCTATTCCCTATGC
AACAAATTATCAAACAGGATATGTCTTGTGACCTGTTTTTTTTTTAAGGACACATTTTTAATAGCTGAAAATCTCTGATAATGAATTAGA
GTGTGTAGTAAACATGAGAATTAGTTATATTATCTTATTTTTAAAATTCAAGACTAAGAACTTCAGAGAATGAAGAGTCTATTAAAATGA
GGTTCATCTTAATGATAGGCAAACCAAACTCATACTGCTTGACATGTTTTGAAAACTGGTAATATTGAGGGTGTACAGCACATGTACTTA
AAAATGACACTGGACTATCTTTTGCTCTGAGCCATGCCACTTACCGAAATTGTAAATACATTTTTCACAAATGCATTGCCAATTATTACC
ATCCCTCAAAGCAATAAATTGTGACAGTTGCTTTAAATGTTTGTCAGCAACTGTTTTCATTTGTTCAGATATTTTGAATAGCTACACTAA
TAACTGTTATTATTTGGTGAACATAAAAAAATAAATAGATCTGTATATTGATGGTAGACTCTCCATATTGAAATGATTATTTTCCAAACA
TTTTCATTTTGGTCAATAATTCAAACTACCACTTAGGCAAAGTATTCGAACACTGTGTCCTTTGTTTAAGGAAATATAAAAAAAAAATCA
CCTTTCTTTTTGTGCAAAAAAAATATTATTTCAATCACATTTCAGAACCGCCAGGGCAAGAAAGTATAAAGCAGGATCATGTTAAGAAAA
AAGAAAAAAAGATCATGAGTCACTTAAATATGTATTTTTATTTGTAACAAACAAGTATTAAACTGTAAAGTATTTTTGTACAAATTTAAT
ACTTTAATAGCATGGTATTTATCGTCTATGTATGGTTTTGGGGAATTCAAAATTGTTCAAATATTTGTATGGAAAAAAATAAAACCCTCT

>91579_91579_3_TMEM120B-GRIP1_TMEM120B_chr12_122211419_ENST00000449592_GRIP1_chr12_66773216_ENST00000398016_length(amino acids)=586AA_BP=279
MGGRSGSAAGAAAGTAALHHRIMSGQLERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLTLQRCKRHA
SREEAELVQQMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDE
VFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALG
ERNHLDLTVGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQTYPDVGLSYEDWDRSTASGFAGAADSAETEQEENFWSQALEDLETCG
QSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIK
EIMSPTPVELHKVTLYKDSDMEDFGFSVADGLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLVI

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Fusion Gene PPI Analysis for TMEM120B-GRIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM120B-GRIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM120B-GRIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource