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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM131-RAPGEF4 (FusionGDB2 ID:91634)

Fusion Gene Summary for TMEM131-RAPGEF4

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM131-RAPGEF4
Fusion gene ID: 91634
HgeneTgene
Gene symbol

TMEM131

RAPGEF4

Gene ID

23505

11069

Gene nametransmembrane protein 131Rap guanine nucleotide exchange factor 4
SynonymsCC28|PRO1048|RW1|YR-23CAMP-GEFII|CGEF2|EPAC|EPAC 2|EPAC2|Nbla00496
Cytomap

2q11.2

2q31.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 1312610524E03Rikrap guanine nucleotide exchange factor 4RAP guanine-nucleotide-exchange factor (GEF) 4Rap guanine nucleotide exchange factor (GEF) 4cAMP-regulated guanine nucleotide exchange factor IIexchange factor directly activated by cAMP 2exchange protein direc
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000186436, ENST00000425805, 
ENST00000473043, ENST00000535187, 
ENST00000264111, ENST00000397081, 
ENST00000397087, ENST00000409036, 
ENST00000538974, ENST00000539331, 
ENST00000540783, 
Fusion gene scores* DoF score14 X 13 X 11=200217 X 18 X 9=2754
# samples 1519
** MAII scorelog2(15/2002*10)=-3.73840756834011
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2754*10)=-3.85745723580402
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM131 [Title/Abstract] AND RAPGEF4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM131(98458278)-RAPGEF4(173855538), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM131 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAPGEF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-FV-A3I1-01ATMEM131chr2

98458278

-RAPGEF4chr2

173855538

+


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Fusion Gene ORF analysis for TMEM131-RAPGEF4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000186436ENST00000473043TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
5CDS-3UTRENST00000186436ENST00000535187TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
5CDS-3UTRENST00000425805ENST00000473043TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
5CDS-3UTRENST00000425805ENST00000535187TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000186436ENST00000264111TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000186436ENST00000397081TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000186436ENST00000397087TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000186436ENST00000409036TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000186436ENST00000538974TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000186436ENST00000539331TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000186436ENST00000540783TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000425805ENST00000264111TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000425805ENST00000397081TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000425805ENST00000397087TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000425805ENST00000409036TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000425805ENST00000538974TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000425805ENST00000539331TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+
In-frameENST00000425805ENST00000540783TMEM131chr2

98458278

-RAPGEF4chr2

173855538

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000186436TMEM131chr298458278-ENST00000264111RAPGEF4chr2173855538+37329522292613794
ENST00000186436TMEM131chr298458278-ENST00000397081RAPGEF4chr2173855538+37349522292613794
ENST00000186436TMEM131chr298458278-ENST00000409036RAPGEF4chr2173855538+35369522292409726
ENST00000186436TMEM131chr298458278-ENST00000397087RAPGEF4chr2173855538+37409522292613794
ENST00000186436TMEM131chr298458278-ENST00000538974RAPGEF4chr2173855538+27499522292613794
ENST00000186436TMEM131chr298458278-ENST00000540783RAPGEF4chr2173855538+30269522292613794
ENST00000186436TMEM131chr298458278-ENST00000539331RAPGEF4chr2173855538+28739522292613794
ENST00000425805TMEM131chr298458278-ENST00000264111RAPGEF4chr2173855538+3382602142263749
ENST00000425805TMEM131chr298458278-ENST00000397081RAPGEF4chr2173855538+3384602142263749
ENST00000425805TMEM131chr298458278-ENST00000409036RAPGEF4chr2173855538+3186602142059681
ENST00000425805TMEM131chr298458278-ENST00000397087RAPGEF4chr2173855538+3390602142263749
ENST00000425805TMEM131chr298458278-ENST00000538974RAPGEF4chr2173855538+2399602142263749
ENST00000425805TMEM131chr298458278-ENST00000540783RAPGEF4chr2173855538+2676602142263749
ENST00000425805TMEM131chr298458278-ENST00000539331RAPGEF4chr2173855538+2523602142263749

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000186436ENST00000264111TMEM131chr298458278-RAPGEF4chr2173855538+0.0008390820.9991609
ENST00000186436ENST00000397081TMEM131chr298458278-RAPGEF4chr2173855538+0.000842680.9991573
ENST00000186436ENST00000409036TMEM131chr298458278-RAPGEF4chr2173855538+0.0008937070.9991062
ENST00000186436ENST00000397087TMEM131chr298458278-RAPGEF4chr2173855538+0.0008490590.999151
ENST00000186436ENST00000538974TMEM131chr298458278-RAPGEF4chr2173855538+0.0028613040.99713874
ENST00000186436ENST00000540783TMEM131chr298458278-RAPGEF4chr2173855538+0.0026919010.99730814
ENST00000186436ENST00000539331TMEM131chr298458278-RAPGEF4chr2173855538+0.002865690.9971343
ENST00000425805ENST00000264111TMEM131chr298458278-RAPGEF4chr2173855538+0.0010225510.9989774
ENST00000425805ENST00000397081TMEM131chr298458278-RAPGEF4chr2173855538+0.0010272220.9989728
ENST00000425805ENST00000409036TMEM131chr298458278-RAPGEF4chr2173855538+0.0009023150.9990977
ENST00000425805ENST00000397087TMEM131chr298458278-RAPGEF4chr2173855538+0.0010335390.99896646
ENST00000425805ENST00000538974TMEM131chr298458278-RAPGEF4chr2173855538+0.0027573880.99724257
ENST00000425805ENST00000540783TMEM131chr298458278-RAPGEF4chr2173855538+0.0026247260.99737525
ENST00000425805ENST00000539331TMEM131chr298458278-RAPGEF4chr2173855538+0.0027391020.9972609

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Fusion Genomic Features for TMEM131-RAPGEF4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMEM131chr298458277-RAPGEF4chr2173855537+0.0003851060.99961483
TMEM131chr298458277-RAPGEF4chr2173855537+0.0003851060.99961483

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMEM131-RAPGEF4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:98458278/chr2:173855538)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAPGEF4chr2:98458278chr2:173855538ENST000003970811331496_6344581012.0DomainN-terminal Ras-GEF
TgeneRAPGEF4chr2:98458278chr2:173855538ENST000003970811331772_10094581012.0DomainRas-GEF
TgeneRAPGEF4chr2:98458278chr2:173855538ENST000003970871028496_634314868.0DomainN-terminal Ras-GEF
TgeneRAPGEF4chr2:98458278chr2:173855538ENST000003970871028772_1009314868.0DomainRas-GEF
TgeneRAPGEF4chr2:98458278chr2:173855538ENST000003970871028356_476314868.0Nucleotide bindingNote=cAMP 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM131chr2:98458278chr2:173855538ENST00000186436-7411297_13322411884.0Compositional biasNote=Pro-rich
HgeneTMEM131chr2:98458278chr2:173855538ENST00000186436-7411379_14742411884.0Compositional biasNote=Lys-rich
HgeneTMEM131chr2:98458278chr2:173855538ENST00000186436-7411626_16302411884.0Compositional biasNote=Poly-Ser
HgeneTMEM131chr2:98458278chr2:173855538ENST00000186436-7411679_18152411884.0Compositional biasNote=Ser-rich
HgeneTMEM131chr2:98458278chr2:173855538ENST00000186436-7411091_11112411884.0TransmembraneHelical
HgeneTMEM131chr2:98458278chr2:173855538ENST00000186436-7411118_11382411884.0TransmembraneHelical
TgeneRAPGEF4chr2:98458278chr2:173855538ENST000003970811331216_2914581012.0DomainDEP
TgeneRAPGEF4chr2:98458278chr2:173855538ENST000003970871028216_291314868.0DomainDEP
TgeneRAPGEF4chr2:98458278chr2:173855538ENST000003970811331356_4764581012.0Nucleotide bindingNote=cAMP 2
TgeneRAPGEF4chr2:98458278chr2:173855538ENST00000397081133143_1664581012.0Nucleotide bindingNote=cAMP 1
TgeneRAPGEF4chr2:98458278chr2:173855538ENST00000397087102843_166314868.0Nucleotide bindingNote=cAMP 1


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Fusion Gene Sequence for TMEM131-RAPGEF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91634_91634_1_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000264111_length(transcript)=3732nt_BP=952nt
CTCCGCTCCGACTGCTTGTAGGCGATGCCCAGGCAAAGACCGTGACTGACACTCTCGCTCACACGCACGCACGGACCCAGGCCCACGCTC
GGAGATCGAGCCCCGGGCTCGCAACCGTTGTCGCTCCCGGCGCCGCGGCCAGAGCCCGGACCACGGCTTCCGCGCCGCCGCCGCCTCGCC
GAGAAGGGCCGCGCCGGACCTCGAGCGCGGCGGCCCCCGGCCGGCAGGGATGGGGAAGCGGGCGGGAGGAGGAGCAACCGGAGCCACCAC
CGCCGCCGTCTCCACGTCCGCCGGGGCCGGGCTGGAACCTGCGGCCGCCCGTAGCGGGGGCCCGCGGAGCGCGGCCGCCGGCCTCCTAGG
CGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAATAGAAGTACT
GCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCTACCGGGGGAA
TTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCTACTTACATAA
TCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATAGGAAAATTCT
TCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATACATCTAATCA
TGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCCCTGTGAATAG
CAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAA
GTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCAT
CCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAAT
GCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCA
GGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACC
ATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCA
CTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATT
ATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTG
CTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAG
TGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAG
GTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATT
ATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATG
TAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAG
AAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCT
ACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCA
AAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTAT
TTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCT

>91634_91634_1_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000264111_length(amino acids)=794AA_BP=234
MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGL
SSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVV
GNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRAS
NQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRV
IRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGS
DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQ
EGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKF
IKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEG

--------------------------------------------------------------
>91634_91634_2_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000397081_length(transcript)=3734nt_BP=952nt
CTCCGCTCCGACTGCTTGTAGGCGATGCCCAGGCAAAGACCGTGACTGACACTCTCGCTCACACGCACGCACGGACCCAGGCCCACGCTC
GGAGATCGAGCCCCGGGCTCGCAACCGTTGTCGCTCCCGGCGCCGCGGCCAGAGCCCGGACCACGGCTTCCGCGCCGCCGCCGCCTCGCC
GAGAAGGGCCGCGCCGGACCTCGAGCGCGGCGGCCCCCGGCCGGCAGGGATGGGGAAGCGGGCGGGAGGAGGAGCAACCGGAGCCACCAC
CGCCGCCGTCTCCACGTCCGCCGGGGCCGGGCTGGAACCTGCGGCCGCCCGTAGCGGGGGCCCGCGGAGCGCGGCCGCCGGCCTCCTAGG
CGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAATAGAAGTACT
GCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCTACCGGGGGAA
TTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCTACTTACATAA
TCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATAGGAAAATTCT
TCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATACATCTAATCA
TGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCCCTGTGAATAG
CAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAA
GTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCAT
CCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAAT
GCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCA
GGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACC
ATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCA
CTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATT
ATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTG
CTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAG
TGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAG
GTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATT
ATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATG
TAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAG
AAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCT
ACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCA
AAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTAT
TTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCT

>91634_91634_2_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000397081_length(amino acids)=794AA_BP=234
MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGL
SSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVV
GNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRAS
NQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRV
IRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGS
DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQ
EGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKF
IKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEG

--------------------------------------------------------------
>91634_91634_3_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000397087_length(transcript)=3740nt_BP=952nt
CTCCGCTCCGACTGCTTGTAGGCGATGCCCAGGCAAAGACCGTGACTGACACTCTCGCTCACACGCACGCACGGACCCAGGCCCACGCTC
GGAGATCGAGCCCCGGGCTCGCAACCGTTGTCGCTCCCGGCGCCGCGGCCAGAGCCCGGACCACGGCTTCCGCGCCGCCGCCGCCTCGCC
GAGAAGGGCCGCGCCGGACCTCGAGCGCGGCGGCCCCCGGCCGGCAGGGATGGGGAAGCGGGCGGGAGGAGGAGCAACCGGAGCCACCAC
CGCCGCCGTCTCCACGTCCGCCGGGGCCGGGCTGGAACCTGCGGCCGCCCGTAGCGGGGGCCCGCGGAGCGCGGCCGCCGGCCTCCTAGG
CGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAATAGAAGTACT
GCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCTACCGGGGGAA
TTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCTACTTACATAA
TCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATAGGAAAATTCT
TCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATACATCTAATCA
TGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCCCTGTGAATAG
CAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAA
GTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCAT
CCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAAT
GCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCA
GGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACC
ATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCA
CTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATT
ATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTG
CTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAG
TGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAG
GTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATT
ATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATG
TAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAG
AAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCT
ACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCA
AAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTAT
TTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCT

>91634_91634_3_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000397087_length(amino acids)=794AA_BP=234
MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGL
SSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVV
GNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRAS
NQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRV
IRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGS
DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQ
EGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKF
IKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEG

--------------------------------------------------------------
>91634_91634_4_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000409036_length(transcript)=3536nt_BP=952nt
CTCCGCTCCGACTGCTTGTAGGCGATGCCCAGGCAAAGACCGTGACTGACACTCTCGCTCACACGCACGCACGGACCCAGGCCCACGCTC
GGAGATCGAGCCCCGGGCTCGCAACCGTTGTCGCTCCCGGCGCCGCGGCCAGAGCCCGGACCACGGCTTCCGCGCCGCCGCCGCCTCGCC
GAGAAGGGCCGCGCCGGACCTCGAGCGCGGCGGCCCCCGGCCGGCAGGGATGGGGAAGCGGGCGGGAGGAGGAGCAACCGGAGCCACCAC
CGCCGCCGTCTCCACGTCCGCCGGGGCCGGGCTGGAACCTGCGGCCGCCCGTAGCGGGGGCCCGCGGAGCGCGGCCGCCGGCCTCCTAGG
CGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAATAGAAGTACT
GCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCTACCGGGGGAA
TTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCTACTTACATAA
TCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATAGGAAAATTCT
TCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATACATCTAATCA
TGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCCCTGTGAATAG
CAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGCGCATGATTGCAAATACGGCCAG
AACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTTATGTACGGCA
ATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAATGCCCAAAGC
AACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTACAAAACAAGCA
AAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTAAAGCTTACAC
ACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACG
TGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGAGATGTGCTAC
AAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCC
AAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTATGGCTGTTTA
TGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAATTTACAAATCA
GGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCAGAAGAGCACA
ATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTACCTGATGAAA
ACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAGTTCATTCAAT
CAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGTAATTTTGAAG
TACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCTTCTGTAAATAACATCTAGTATCTT

>91634_91634_4_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000409036_length(amino acids)=726AA_BP=234
MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGL
SSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVV
GNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRAS
NQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRV
IRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGS
DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQ
EGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKF
IKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWERMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHR

--------------------------------------------------------------
>91634_91634_5_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000538974_length(transcript)=2749nt_BP=952nt
CTCCGCTCCGACTGCTTGTAGGCGATGCCCAGGCAAAGACCGTGACTGACACTCTCGCTCACACGCACGCACGGACCCAGGCCCACGCTC
GGAGATCGAGCCCCGGGCTCGCAACCGTTGTCGCTCCCGGCGCCGCGGCCAGAGCCCGGACCACGGCTTCCGCGCCGCCGCCGCCTCGCC
GAGAAGGGCCGCGCCGGACCTCGAGCGCGGCGGCCCCCGGCCGGCAGGGATGGGGAAGCGGGCGGGAGGAGGAGCAACCGGAGCCACCAC
CGCCGCCGTCTCCACGTCCGCCGGGGCCGGGCTGGAACCTGCGGCCGCCCGTAGCGGGGGCCCGCGGAGCGCGGCCGCCGGCCTCCTAGG
CGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAATAGAAGTACT
GCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCTACCGGGGGAA
TTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCTACTTACATAA
TCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATAGGAAAATTCT
TCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATACATCTAATCA
TGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCCCTGTGAATAG
CAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAA
GTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCAT
CCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAAT
GCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCA
GGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACC
ATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCA

>91634_91634_5_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000538974_length(amino acids)=794AA_BP=234
MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGL
SSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVV
GNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRAS
NQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRV
IRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGS
DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQ
EGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKF
IKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEG

--------------------------------------------------------------
>91634_91634_6_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000539331_length(transcript)=2873nt_BP=952nt
CTCCGCTCCGACTGCTTGTAGGCGATGCCCAGGCAAAGACCGTGACTGACACTCTCGCTCACACGCACGCACGGACCCAGGCCCACGCTC
GGAGATCGAGCCCCGGGCTCGCAACCGTTGTCGCTCCCGGCGCCGCGGCCAGAGCCCGGACCACGGCTTCCGCGCCGCCGCCGCCTCGCC
GAGAAGGGCCGCGCCGGACCTCGAGCGCGGCGGCCCCCGGCCGGCAGGGATGGGGAAGCGGGCGGGAGGAGGAGCAACCGGAGCCACCAC
CGCCGCCGTCTCCACGTCCGCCGGGGCCGGGCTGGAACCTGCGGCCGCCCGTAGCGGGGGCCCGCGGAGCGCGGCCGCCGGCCTCCTAGG
CGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAATAGAAGTACT
GCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCTACCGGGGGAA
TTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCTACTTACATAA
TCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATAGGAAAATTCT
TCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATACATCTAATCA
TGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCCCTGTGAATAG
CAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAA
GTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCAT
CCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAAT
GCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCA
GGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACC
ATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCA
CTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATT

>91634_91634_6_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000539331_length(amino acids)=794AA_BP=234
MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGL
SSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVV
GNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRAS
NQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRV
IRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGS
DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQ
EGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKF
IKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEG

--------------------------------------------------------------
>91634_91634_7_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000540783_length(transcript)=3026nt_BP=952nt
CTCCGCTCCGACTGCTTGTAGGCGATGCCCAGGCAAAGACCGTGACTGACACTCTCGCTCACACGCACGCACGGACCCAGGCCCACGCTC
GGAGATCGAGCCCCGGGCTCGCAACCGTTGTCGCTCCCGGCGCCGCGGCCAGAGCCCGGACCACGGCTTCCGCGCCGCCGCCGCCTCGCC
GAGAAGGGCCGCGCCGGACCTCGAGCGCGGCGGCCCCCGGCCGGCAGGGATGGGGAAGCGGGCGGGAGGAGGAGCAACCGGAGCCACCAC
CGCCGCCGTCTCCACGTCCGCCGGGGCCGGGCTGGAACCTGCGGCCGCCCGTAGCGGGGGCCCGCGGAGCGCGGCCGCCGGCCTCCTAGG
CGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAATAGAAGTACT
GCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCTACCGGGGGAA
TTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCTACTTACATAA
TCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATAGGAAAATTCT
TCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATACATCTAATCA
TGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCCCTGTGAATAG
CAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTAAAGAACATGA
CCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGTATACTGTGAT
GTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATTCTGTTTTAAA
TGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGCCTTCACAAGG
TACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGTATGGAGACCT
CCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTGCCCTCAAGGA
GCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTTTGCAACAGTT
CAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGGACCACACCTA
CACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGGGCCTGATCAT
AGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATGGACGCCTGTT
TGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTTTTGAACTGAT
GAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCTATCACACATT
TGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCGTCACTGAGAT
CTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATAAAAATCTGAA
TTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCAAGTTCAAGAA
GTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAACCTCCTCTCAT
CCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACTTTGAAAAAAT
GCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCA
GGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACC
ATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCA
CTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATT
ATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTG
CTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAG

>91634_91634_7_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000186436_RAPGEF4_chr2_173855538_ENST00000540783_length(amino acids)=794AA_BP=234
MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGL
SSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVV
GNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRAS
NQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRV
IRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGS
DEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQ
EGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKF
IKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEG

--------------------------------------------------------------
>91634_91634_8_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000264111_length(transcript)=3382nt_BP=602nt
AGTATGGCCGCGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAA
TAGAAGTACTGCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCT
ACCGGGGGAATTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCT
ACTTACATAATCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATA
GGAAAATTCTTCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATA
CATCTAATCATGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCC
CTGTGAATAGCAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTA
AAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGT
ATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATT
CTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGC
CTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGT
ATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTG
CCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTT
TGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGG
ACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGG
GCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATG
GACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTT
TTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCT
ATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCG
TCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATA
AAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCA
AGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAAC
CTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACT
TTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATA
AGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGC
CTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGAC
TGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAG
AGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCC
ATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTT
TTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGG
TTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACC
TGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTAT
GTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGC
GTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTT
ACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTT
TGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACT
TTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGT

>91634_91634_8_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000264111_length(amino acids)=749AA_BP=189
MHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNP
SSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSS
FSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLND
FIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQ
LPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV
KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFG
RHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF
YAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQD

--------------------------------------------------------------
>91634_91634_9_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000397081_length(transcript)=3384nt_BP=602nt
AGTATGGCCGCGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAA
TAGAAGTACTGCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCT
ACCGGGGGAATTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCT
ACTTACATAATCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATA
GGAAAATTCTTCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATA
CATCTAATCATGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCC
CTGTGAATAGCAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTA
AAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGT
ATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATT
CTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGC
CTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGT
ATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTG
CCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTT
TGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGG
ACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGG
GCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATG
GACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTT
TTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCT
ATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCG
TCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATA
AAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCA
AGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAAC
CTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACT
TTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATA
AGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGC
CTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGAC
TGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAG
AGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCC
ATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTT
TTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGG
TTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACC
TGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTAT
GTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGC
GTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTT
ACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTT
TGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACT
TTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGT

>91634_91634_9_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000397081_length(amino acids)=749AA_BP=189
MHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNP
SSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSS
FSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLND
FIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQ
LPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV
KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFG
RHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF
YAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQD

--------------------------------------------------------------
>91634_91634_10_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000397087_length(transcript)=3390nt_BP=602nt
AGTATGGCCGCGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAA
TAGAAGTACTGCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCT
ACCGGGGGAATTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCT
ACTTACATAATCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATA
GGAAAATTCTTCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATA
CATCTAATCATGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCC
CTGTGAATAGCAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTA
AAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGT
ATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATT
CTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGC
CTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGT
ATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTG
CCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTT
TGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGG
ACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGG
GCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATG
GACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTT
TTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCT
ATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCG
TCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATA
AAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCA
AGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAAC
CTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACT
TTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATA
AGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGC
CTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGAC
TGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAG
AGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCC
ATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTT
TTTCTAAGAGTGTTTATGGGATGAGATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGG
TTTCGGGAAGGTGTTGAGGAATCTATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACC
TGACCACATTATTATGAAACATTATGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTAT
GTTTACAATGTAACTTTTCAAAATTTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGC
GTTAAAGTAGAAAATAACATTTCAGAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTT
ACTATTGGCTACAAATTTATTGTACCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTT
TGCACTTTCAAAGATTGTAAATAGTTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACT
TTTTATTTATTTTATTTAGTACGTAATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGT

>91634_91634_10_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000397087_length(amino acids)=749AA_BP=189
MHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNP
SSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSS
FSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLND
FIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQ
LPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV
KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFG
RHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF
YAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQD

--------------------------------------------------------------
>91634_91634_11_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000409036_length(transcript)=3186nt_BP=602nt
AGTATGGCCGCGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAA
TAGAAGTACTGCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCT
ACCGGGGGAATTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCT
ACTTACATAATCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATA
GGAAAATTCTTCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATA
CATCTAATCATGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCC
CTGTGAATAGCAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTA
AAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGT
ATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATT
CTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGC
CTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGT
ATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTG
CCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTT
TGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGG
ACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGG
GCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATG
GACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTT
TTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCT
ATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCG
TCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATA
AAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGCGCATGATTGCAA
ATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATAAGAACCATCAGGATGTCCGGAGTT
ATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGCCTCGTCGACCATAGACATTTCAAA
TGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGACTGTATTGCCACTAGAGAATTCTAC
AAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAGAGAAGGAATTATTTGACATGCCTA
AAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCCATCTTCTTTGCTGAAGTGTTGAAT
AAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTTTTTCTAAGAGTGTTTATGGGATGA
GATGTGCTACAAATGGGATAGATTTGGATAAAATTTTAACTCAACATCTTGATTTGGAGCCTGGGGTTTCGGGAAGGTGTTGAGGAATCT
ATAGAAGTCCAAATTATAGGTTGTATTCTTCCATCTTCATTGTCTTACCTCTGAAGGAATAGAACCTGACCACATTATTATGAAACATTA
TGGCTGTTTATGTAATTTAGGGAGGACTGGTCTGTAATTTCTGAATGTATATAGAATAATATTTATGTTTACAATGTAACTTTTCAAAAT
TTACAAATCAGGATTATATACATAAGAATTCCACTAAGAAATGCCAAGATTCTTAAATTTGCCAGCGTTAAAGTAGAAAATAACATTTCA
GAAGAGCACAATATGCATAAAACATTTTTCAAAATTGAAATATTTTCCTGGGCATTAAAAACCTTTACTATTGGCTACAAATTTATTGTA
CCTGATGAAAACATATTTTCTGGACTTAAATGTTATTACAAATATCTTAATTTTCAGTAATTGTTTTGCACTTTCAAAGATTGTAAATAG
TTCATTCAATCAATGGTATGGAGTTATTTATTTGCTACATAATAGATACTGTGCCAAATAATTACTTTTTATTTATTTTATTTAGTACGT
AATTTTGAAGTACATTTTTTCCTGTTTTCACAATTAGACTACATTTAATGTGTAGGAATTGTATGTATGTATATCTTCTGTAAATAACAT

>91634_91634_11_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000409036_length(amino acids)=681AA_BP=189
MHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNP
SSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSS
FSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLND
FIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQ
LPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV
KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFG
RHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWERMIANTART

--------------------------------------------------------------
>91634_91634_12_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000538974_length(transcript)=2399nt_BP=602nt
AGTATGGCCGCGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAA
TAGAAGTACTGCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCT
ACCGGGGGAATTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCT
ACTTACATAATCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATA
GGAAAATTCTTCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATA
CATCTAATCATGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCC
CTGTGAATAGCAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTA
AAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGT
ATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATT
CTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGC
CTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGT
ATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTG
CCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTT
TGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGG
ACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGG
GCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATG
GACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTT
TTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCT
ATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCG
TCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATA
AAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCA
AGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAAC
CTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACT
TTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATA
AGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGC
CTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGAC

>91634_91634_12_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000538974_length(amino acids)=749AA_BP=189
MHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNP
SSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSS
FSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLND
FIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQ
LPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV
KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFG
RHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF
YAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQD

--------------------------------------------------------------
>91634_91634_13_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000539331_length(transcript)=2523nt_BP=602nt
AGTATGGCCGCGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAA
TAGAAGTACTGCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCT
ACCGGGGGAATTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCT
ACTTACATAATCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATA
GGAAAATTCTTCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATA
CATCTAATCATGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCC
CTGTGAATAGCAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTA
AAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGT
ATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATT
CTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGC
CTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGT
ATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTG
CCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTT
TGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGG
ACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGG
GCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATG
GACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTT
TTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCT
ATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCG
TCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATA
AAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCA
AGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAAC
CTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACT
TTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATA
AGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGC
CTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGAC
TGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAG
AGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCC

>91634_91634_13_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000539331_length(amino acids)=749AA_BP=189
MHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNP
SSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSS
FSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLND
FIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQ
LPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV
KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFG
RHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF
YAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQD

--------------------------------------------------------------
>91634_91634_14_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000540783_length(transcript)=2676nt_BP=602nt
AGTATGGCCGCGCGCTGCACCTGGTGATGACCCTCGTAGTGGCTGCGGCGCGGGCCGAGAAGGAAGCATTCGTTCAGTCAGAGAGCATAA
TAGAAGTACTGCGTTTTGATGATGGAGGGCTACTACAGACCGAGACAACACTTGGACTCAGTTCATATCAGCAGAAAAGTATATCTCTCT
ACCGGGGGAATTGCAGGCCCATACGATTTGAGCCACCAATGCTGGATTTCCATGAACAACCAGTTGGAATGCCAAAAATGGAAAAAGTCT
ACTTACATAATCCTAGTTCTGAAGAAACGATTACTTTAGTATCAATATCTGCTACAACATCACATTTTCATGCATCATTTTTTCAAAATA
GGAAAATTCTTCCAGGAGGAAATACATCATTTGATGTAGTTTTTCTTGCAAGAGTAGTAGGAAATGTAGAAAATACTTTATTTATTAATA
CATCTAATCATGGGGTATTTACTTACCAGGTATTTGGTGTTGGAGTTCCAAATCCATATCGATTGAGGCCGTTCCTTGGGGCCAGAGTCC
CTGTGAATAGCAGTTTCTCACCTATAATAAACATCCACAATCCTCACAGTGAGCCTTTACAGGACGTGGAGGCGAATACAGTCAGACTTA
AAGAACATGACCAAGATGTCTTGGTGCTGGAGAAGGTCCCAGCAGGGAACAGAGCTTCTAATCAAGGAAACTCACAGCCTCAGCAAAAGT
ATACTGTGATGTCAGGAACACCTGAAAAAATTTTAGAGCATTTTCTAGAAACAATACGCCTTGAGGCAACTTTAAATGAAGCAACAGATT
CTGTTTTAAATGACTTTATTATGATGCACTGTGTTTTTATGCCAAATACCCAGCTTTGCCCGGCACTGGTGGCCCACTACCACGCACAGC
CTTCACAAGGTACAGAACAGGAGAAAATGGATTATGCCCTCAACAATAAGAGGCGAGTCATCCGCCTGGTTCTACAGTGGGCTGCCATGT
ATGGAGACCTCCTGCAAGAGGATGACGTGTCTATGGCCTTCCTGGAGGAGTTTTATGTATCTGTATCAGATGATGCCCGGATGATTGCTG
CCCTCAAGGAGCAACTGCCAGAGTTGGAGAAGATTGTCAAGCAAATCTCAGAAGATGCAAAGGCACCACAAAAGAAGCACAAGGTTCTTT
TGCAACAGTTCAATACGGGCGATGAGAGAGCCCAGAAGCGCCAGCCTATCCGCGGCTCTGATGAAGTTCTGTTTAAGGTCTATTGCATGG
ACCACACCTACACAACCATTCGGGTGCCAGTGGCCACTTCGGTGAAGGAAGTCATCAGTGCAGTTGCCGACAAGCTGGGCTCCGGGGAGG
GCCTGATCATAGTCAAGATGAGTTCCGGAGGAGAAAAGGTGGTGCTCAAACCTAATGATGTTTCAGTATTTACGACGCTCACCATTAATG
GACGCCTGTTTGCTTGCCCGCGAGAGCAATTCGATTCACTGACTCCCTTACCAGAACAGGAAGGCCCAACTGTTGGAACAGTGGGAACTT
TTGAACTGATGAGCTCCAAAGATTTAGCATACCAGATGACAATTTATGATTGGGAACTCTTCAACTGCGTGCATGAGCTGGAGCTAATCT
ATCACACATTTGGAAGGCATAATTTTAAAAAGACCACAGCAAACTTGGATTTGTTCCTGAGGAGATTTAATGAAATTCAGTTTTGGGTCG
TCACTGAGATCTGCCTTTGTTCTCAGCTCAGCAAGCGTGTTCAGCTATTAAAAAAATTTATTAAGATAGCAGCCCACTGTAAGGAGTATA
AAAATCTGAATTCCTTTTTTGCCATCGTCATGGGACTAAGTAACGTTGCTGTGAGCCGCTTGGCACTAACGTGGGAGAAACTGCCAAGCA
AGTTCAAGAAGTTCTATGCGGAGTTTGAAAGTTTAATGGACCCTTCAAGGAACCACAGGGCCTACAGGCTGACAGTAGCTAAGCTGGAAC
CTCCTCTCATCCCCTTCATGCCTTTGCTCATTAAAGATATGACATTTACTCATGAGGGGAACAAGACGTTCATTGACAATCTAGTAAACT
TTGAAAAAATGCGCATGATTGCAAATACGGCCAGAACAGTGAGATACTACAGGAGCCAACCCTTCAATCCTGATGCAGCTCAAGCTAATA
AGAACCATCAGGATGTCCGGAGTTATGTACGGCAATTAAATGTGATTGACAACCAGAGAACTTTATCACAGATGTCACACAGATTAGAGC
CTCGTCGACCATAGACATTTCAAATGCCCAAAGCAACAGTTTGTCTCCAGTCCACAATCTTTCAAAAATGCCATTTATGCTACTACTGAC
TGTATTGCCACTAGAGAATTCTACAAAACAAGCAAAAACACATCCTGAGACACCTCAGGGCTGCATTCAGCTTACCAGCTACCTAGCAAG
AGAAGGAATTATTTGACATGCCTAAAGCTTACACACTCTAGCTTAGGAATCCCCAGTTTGTGGCTACCCTGTTTCATTTCCACTTGTGCC
ATCTTCTTTGCTGAAGTGTTGAATAAGGCCCACGTGAAGAGTTTGGTAGAAATAGCCTTGTCAAGAGAACTAGCAAGCCCCTGACATTTT

>91634_91634_14_TMEM131-RAPGEF4_TMEM131_chr2_98458278_ENST00000425805_RAPGEF4_chr2_173855538_ENST00000540783_length(amino acids)=749AA_BP=189
MHLVMTLVVAAARAEKEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNP
SSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSS
FSPIINIHNPHSEPLQDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLND
FIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQ
LPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIV
KMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFG
RHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKF
YAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQD

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Fusion Gene PPI Analysis for TMEM131-RAPGEF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM131-RAPGEF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM131-RAPGEF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource