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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM159-NDUFAB1 (FusionGDB2 ID:91734)

Fusion Gene Summary for TMEM159-NDUFAB1

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM159-NDUFAB1
	Fusion gene ID: 91734
		Hgene	Tgene
	Gene symbol	TMEM159	NDUFAB1
	Gene ID	57146	4706
	Gene name	transmembrane protein 159	NADH:ubiquinone oxidoreductase subunit AB1
	Synonyms	-	ACP\|ACP1\|FASN2A\|SDAP
	Cytomap	16p12.3	16p12.2
	Type of gene	protein-coding	protein-coding
	Description	promethin	acyl carrier protein, mitochondrialCI-SDAPNADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDaNADH-ubiquinone oxidoreductase 9.6 kDa subunitNADH:ubiquinone oxidoreductase SDAP subunitcomplex I SDAP subunitmitochondrial acyl carrier prot
	Modification date	20200327	20200313
	UniProtAcc	.	O14561
	Ensembl transtripts involved in fusion gene	ENST00000574092, ENST00000233047, ENST00000261388, ENST00000451578, ENST00000572258, ENST00000572599,	ENST00000007516, ENST00000570319,
Fusion gene scores	* DoF score	3 X 3 X 3=27	2 X 1 X 2=4
	# samples	3	2
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(2/4*10)=2.32192809488736
Context	PubMed: TMEM159 [Title/Abstract] AND NDUFAB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM159(21172599)-NDUFAB1(23598640), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMEM159 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NDUFAB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-AB3A-01A	TMEM159	chr16	21172599	-	NDUFAB1	chr16	23598640	-
ChimerDB4	SARC	TCGA-DX-AB3A-01A	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-

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Fusion Gene ORF analysis for TMEM159-NDUFAB1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000574092	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
3UTR-3CDS	ENST00000574092	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000233047	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000233047	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000261388	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000261388	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000451578	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000451578	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000572258	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000572258	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000572599	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-
In-frame	ENST00000572599	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000233047	TMEM159	chr16	21172599	+	ENST00000007516	NDUFAB1	chr16	23598640	-	1047	564	631	83	182
ENST00000233047	TMEM159	chr16	21172599	+	ENST00000570319	NDUFAB1	chr16	23598640	-	1280	564	631	83	182
ENST00000572258	TMEM159	chr16	21172599	+	ENST00000007516	NDUFAB1	chr16	23598640	-	763	280	184	582	132
ENST00000572258	TMEM159	chr16	21172599	+	ENST00000570319	NDUFAB1	chr16	23598640	-	996	280	184	582	132
ENST00000261388	TMEM159	chr16	21172599	+	ENST00000007516	NDUFAB1	chr16	23598640	-	852	369	273	671	132
ENST00000261388	TMEM159	chr16	21172599	+	ENST00000570319	NDUFAB1	chr16	23598640	-	1085	369	273	671	132
ENST00000451578	TMEM159	chr16	21172599	+	ENST00000007516	NDUFAB1	chr16	23598640	-	735	252	156	554	132
ENST00000451578	TMEM159	chr16	21172599	+	ENST00000570319	NDUFAB1	chr16	23598640	-	968	252	156	554	132
ENST00000572599	TMEM159	chr16	21172599	+	ENST00000007516	NDUFAB1	chr16	23598640	-	750	267	171	569	132
ENST00000572599	TMEM159	chr16	21172599	+	ENST00000570319	NDUFAB1	chr16	23598640	-	983	267	171	569	132

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000233047	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.010134664	0.98986536
ENST00000233047	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.009981213	0.9900187
ENST00000572258	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.00529033	0.9947096
ENST00000572258	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.008572621	0.9914274
ENST00000261388	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.00493729	0.99506277
ENST00000261388	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.007385746	0.99261427
ENST00000451578	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.005182273	0.9948177
ENST00000451578	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.010149963	0.98985004
ENST00000572599	ENST00000007516	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.004171797	0.9958282
ENST00000572599	ENST00000570319	TMEM159	chr16	21172599	+	NDUFAB1	chr16	23598640	-	0.006141424	0.99385864

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Fusion Genomic Features for TMEM159-NDUFAB1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM159-NDUFAB1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:21172599/chr16:23598640)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NDUFAB1 O14561
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). {ECO:0000250\|UniProtKB:P52505, ECO:0000269\|PubMed:27626371}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NDUFAB1

chr16:21172599

chr16:23598640

ENST00000007516

77_152

128.66666666666666

Domain

Carrier

Tgene

NDUFAB1

chr16:21172599

chr16:23598640

ENST00000570319

77_152

157.0

Domain

Carrier

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000233047

111_116

162.0

Topological domain

Lumenal

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000233047

134_161

162.0

Topological domain

Cytoplasmic

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000233047

1_43

162.0

Topological domain

Cytoplasmic

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000233047

62_67

162.0

Topological domain

Lumenal

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000233047

88_93

162.0

Topological domain

Cytoplasmic

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000261388

111_116

162.0

Topological domain

Lumenal

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000261388

134_161

162.0

Topological domain

Cytoplasmic

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000261388

1_43

162.0

Topological domain

Cytoplasmic

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000261388

62_67

162.0

Topological domain

Lumenal

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000261388

88_93

162.0

Topological domain

Cytoplasmic

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000572599

111_116

162.0

Topological domain

Lumenal

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000572599

134_161

162.0

Topological domain

Cytoplasmic

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000572599

1_43

162.0

Topological domain

Cytoplasmic

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000572599

62_67

162.0

Topological domain

Lumenal

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000572599

88_93

162.0

Topological domain

Cytoplasmic

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000233047

117_133

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000233047

44_61

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000233047

68_87

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000233047

94_110

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000261388

117_133

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000261388

44_61

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000261388

68_87

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000261388

94_110

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000572599

117_133

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000572599

44_61

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000572599

68_87

162.0

Transmembrane

Helical

Hgene

TMEM159

chr16:21172599

chr16:23598640

ENST00000572599

94_110

162.0

Transmembrane

Helical

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Fusion Gene Sequence for TMEM159-NDUFAB1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91734_91734_1_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000233047_NDUFAB1_chr16_23598640_ENST00000007516_length(transcript)=1047nt_BP=564nt
TGTCTTGAAGGTGGTCTGAGCTTTCTCACTCCAAGCCAGTCGTGTGGGAAGGGACACTCTCTGAGCCTCAGTTTCCTCAGCTGTCAACCT
CTCAGGGCTTGTTCTAGTGGCTCCGAAAGCCAGTGGGAGCGAGCGCGCTTTGCAAAGCCTTGGGCGCCGGGCCTTGGCGCGCCTTTGCCG
GATCCTTCCGGCCACGGGCGGGGCGAGCCCAGAGGAGAAGAGCCGAGGGGCGGTGCCCGGGCCAGGGGGCGGAGGCAGGCGGCTCTGGCT
CCCTCTCGGGACGCTCTTTCCTTCTTCCTCTTGTTCCTCCTCCTGCCTCTCTTCGCTTCGCCTGCAAACGCGGTGGGGGCTGCTCGGCGG
TCAGGAGCAGCAAGAGACAGAGCGACATGAGAGATTGGACCGCGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAG
ATTGAAGTGAGCTTCAGAATGGCAAAAGAGGAGCCCCAGAGTATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATA
GACTCCTTCCAGAATAACTCAAAGGTTCCTGGTAGAGTTACACAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGC
ATCCAGGACCGTGTTCTTTACGTATTGAAACTCTATGACAAGATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTG
GGCTTAGACAGTTTGGACCAAGTGGAGATTATCATGGCCATGGAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTA
ATGTGTCCACAAGAAATTGTAGATTACATTGCAGATAAGAAGGATGTATATGAATAAAGTATCAGACCCTTTGGCTTTGCTGAGAGAGGA
CTCAGATGATAGTGACGAATGTCTGGCAGTGAGGACACATTTTGGCATTCTTGCTGACTCTGACAGAGTGATTCTGATGGACTTGTATTT

>91734_91734_1_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000233047_NDUFAB1_chr16_23598640_ENST00000007516_length(amino acids)=182AA_BP=0
MPSNVKGGMSLYWRHNCVTLPGTFELFWKESISRDSFFCSSCKSLEILWGSSFAILKLTSISLGMNYPTSKFSSAARGPISHVALSLAAP
DRRAAPTAFAGEAKRGRRRNKRKKERASREGARAACLRPLARAPPLGSSPLGSPRPWPEGSGKGAPRPGAQGFAKRARSHWLSEPLEQAL

--------------------------------------------------------------
>91734_91734_2_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000233047_NDUFAB1_chr16_23598640_ENST00000570319_length(transcript)=1280nt_BP=564nt
TGTCTTGAAGGTGGTCTGAGCTTTCTCACTCCAAGCCAGTCGTGTGGGAAGGGACACTCTCTGAGCCTCAGTTTCCTCAGCTGTCAACCT
CTCAGGGCTTGTTCTAGTGGCTCCGAAAGCCAGTGGGAGCGAGCGCGCTTTGCAAAGCCTTGGGCGCCGGGCCTTGGCGCGCCTTTGCCG
GATCCTTCCGGCCACGGGCGGGGCGAGCCCAGAGGAGAAGAGCCGAGGGGCGGTGCCCGGGCCAGGGGGCGGAGGCAGGCGGCTCTGGCT
CCCTCTCGGGACGCTCTTTCCTTCTTCCTCTTGTTCCTCCTCCTGCCTCTCTTCGCTTCGCCTGCAAACGCGGTGGGGGCTGCTCGGCGG
TCAGGAGCAGCAAGAGACAGAGCGACATGAGAGATTGGACCGCGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAG
ATTGAAGTGAGCTTCAGAATGGCAAAAGAGGAGCCCCAGAGTATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATA
GACTCCTTCCAGAATAACTCAAAGGTTCCTGGTAGAGTTACACAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGC
ATCCAGGACCGTGTTCTTTACGTATTGAAACTCTATGACAAGATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTG
GGCTTAGACAGTTTGGACCAAGTGGAGATTATCATGGCCATGGAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTA
ATGTGTCCACAAGAAATTGTAGATTACATTGCAGATAAGAAGGATGTATATGAATAAAGTATCAGGTAAATAGACTTAAAAAATGATGTT
CACCCATAGATTTGTCTGTGGTTCTTCAATAAAGGAAACTTAAGAAGAAACAGAAAATGGAAATGCTTGACCAAGATTTTTCACTACTTA
TAAAATGCAAGCCCTTTCCTGTTGTCTGCCACTCAAAGGGGCCCAGCCCTGGTGGTGATCTTTGAGAGGTTGAGAACTGTCATTCCTGGA
TAGAACTCCCTTGATTGTCAGCTGTCCTCACAAAAGCAGAACATTGTACAAAGTACTGAACAGGGTAACCTGGAAACAGACCTCTGTCTC
CCTCAATTACTCAGCCAAGGTAAGCCCAGCCTGCTGGGTAAGACACTGAAGTGACCTGGCTCTTAAGTAGGCAAGAGAGGCCTCATGTAT

>91734_91734_2_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000233047_NDUFAB1_chr16_23598640_ENST00000570319_length(amino acids)=182AA_BP=0
MPSNVKGGMSLYWRHNCVTLPGTFELFWKESISRDSFFCSSCKSLEILWGSSFAILKLTSISLGMNYPTSKFSSAARGPISHVALSLAAP
DRRAAPTAFAGEAKRGRRRNKRKKERASREGARAACLRPLARAPPLGSSPLGSPRPWPEGSGKGAPRPGAQGFAKRARSHWLSEPLEQAL

--------------------------------------------------------------
>91734_91734_3_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000261388_NDUFAB1_chr16_23598640_ENST00000007516_length(transcript)=852nt_BP=369nt
GTTCCTCCTCCTGCCTCTCTTCGCTTCGCCTGCAAACGCGGTGGGGGCTGCTCGGCGGTCAGGAGCAGGTTACCCTCCGTCTGCATGCCC
ACCATCAAGGTATGAGGATGGTAGAAGCTCTCGTCGAACCAGATGGATGAAGACCACTAACGGCTTTTGTTTCCTCTGGTAACAGCAAGA
GACAGAGCGACATGAGAGATTGGACCGCGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAGATTGAAGTGAGCTTC
AGAATGGCAAAAGAGGAGCCCCAGAGTATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATAGACTCCTTCCAGAAT
AACTCAAAGGTTCCTGGTAGAGTTACACAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGCATCCAGGACCGTGTT
CTTTACGTATTGAAACTCTATGACAAGATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTGGGCTTAGACAGTTTG
GACCAAGTGGAGATTATCATGGCCATGGAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTAATGTGTCCACAAGAA
ATTGTAGATTACATTGCAGATAAGAAGGATGTATATGAATAAAGTATCAGACCCTTTGGCTTTGCTGAGAGAGGACTCAGATGATAGTGA
CGAATGTCTGGCAGTGAGGACACATTTTGGCATTCTTGCTGACTCTGACAGAGTGATTCTGATGGACTTGTATTTAAATTGTATGTGTTT

>91734_91734_3_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000261388_NDUFAB1_chr16_23598640_ENST00000007516_length(amino acids)=132AA_BP=32
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLD

--------------------------------------------------------------
>91734_91734_4_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000261388_NDUFAB1_chr16_23598640_ENST00000570319_length(transcript)=1085nt_BP=369nt
GTTCCTCCTCCTGCCTCTCTTCGCTTCGCCTGCAAACGCGGTGGGGGCTGCTCGGCGGTCAGGAGCAGGTTACCCTCCGTCTGCATGCCC
ACCATCAAGGTATGAGGATGGTAGAAGCTCTCGTCGAACCAGATGGATGAAGACCACTAACGGCTTTTGTTTCCTCTGGTAACAGCAAGA
GACAGAGCGACATGAGAGATTGGACCGCGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAGATTGAAGTGAGCTTC
AGAATGGCAAAAGAGGAGCCCCAGAGTATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATAGACTCCTTCCAGAAT
AACTCAAAGGTTCCTGGTAGAGTTACACAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGCATCCAGGACCGTGTT
CTTTACGTATTGAAACTCTATGACAAGATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTGGGCTTAGACAGTTTG
GACCAAGTGGAGATTATCATGGCCATGGAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTAATGTGTCCACAAGAA
ATTGTAGATTACATTGCAGATAAGAAGGATGTATATGAATAAAGTATCAGGTAAATAGACTTAAAAAATGATGTTCACCCATAGATTTGT
CTGTGGTTCTTCAATAAAGGAAACTTAAGAAGAAACAGAAAATGGAAATGCTTGACCAAGATTTTTCACTACTTATAAAATGCAAGCCCT
TTCCTGTTGTCTGCCACTCAAAGGGGCCCAGCCCTGGTGGTGATCTTTGAGAGGTTGAGAACTGTCATTCCTGGATAGAACTCCCTTGAT
TGTCAGCTGTCCTCACAAAAGCAGAACATTGTACAAAGTACTGAACAGGGTAACCTGGAAACAGACCTCTGTCTCCCTCAATTACTCAGC
CAAGGTAAGCCCAGCCTGCTGGGTAAGACACTGAAGTGACCTGGCTCTTAAGTAGGCAAGAGAGGCCTCATGTATAAGAGGATGGACTTT

>91734_91734_4_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000261388_NDUFAB1_chr16_23598640_ENST00000570319_length(amino acids)=132AA_BP=32
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLD

--------------------------------------------------------------
>91734_91734_5_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000451578_NDUFAB1_chr16_23598640_ENST00000007516_length(transcript)=735nt_BP=252nt
CTGCCTCTCTTCGCTTCGCCTGCAAACGCGGTGGGGGCTGCTCGGCGGTCAGGAGCAGCAAGAGACAGAGCGACATGAGAGATTGGACCG
CGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAGATTGAAGTGAGCTTCAGAATGGCAAAAGAGGAGCCCCAGAGT
ATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATAGACTCCTTCCAGAATAACTCAAAGGTTCCTGGTAGAGTTACA
CAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGCATCCAGGACCGTGTTCTTTACGTATTGAAACTCTATGACAAG
ATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTGGGCTTAGACAGTTTGGACCAAGTGGAGATTATCATGGCCATG
GAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTAATGTGTCCACAAGAAATTGTAGATTACATTGCAGATAAGAAG
GATGTATATGAATAAAGTATCAGACCCTTTGGCTTTGCTGAGAGAGGACTCAGATGATAGTGACGAATGTCTGGCAGTGAGGACACATTT
TGGCATTCTTGCTGACTCTGACAGAGTGATTCTGATGGACTTGTATTTAAATTGTATGTGTTTTACTCTTTGAAAATAAATCTATAAAAC

>91734_91734_5_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000451578_NDUFAB1_chr16_23598640_ENST00000007516_length(amino acids)=132AA_BP=32
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLD

--------------------------------------------------------------
>91734_91734_6_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000451578_NDUFAB1_chr16_23598640_ENST00000570319_length(transcript)=968nt_BP=252nt
CTGCCTCTCTTCGCTTCGCCTGCAAACGCGGTGGGGGCTGCTCGGCGGTCAGGAGCAGCAAGAGACAGAGCGACATGAGAGATTGGACCG
CGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAGATTGAAGTGAGCTTCAGAATGGCAAAAGAGGAGCCCCAGAGT
ATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATAGACTCCTTCCAGAATAACTCAAAGGTTCCTGGTAGAGTTACA
CAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGCATCCAGGACCGTGTTCTTTACGTATTGAAACTCTATGACAAG
ATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTGGGCTTAGACAGTTTGGACCAAGTGGAGATTATCATGGCCATG
GAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTAATGTGTCCACAAGAAATTGTAGATTACATTGCAGATAAGAAG
GATGTATATGAATAAAGTATCAGGTAAATAGACTTAAAAAATGATGTTCACCCATAGATTTGTCTGTGGTTCTTCAATAAAGGAAACTTA
AGAAGAAACAGAAAATGGAAATGCTTGACCAAGATTTTTCACTACTTATAAAATGCAAGCCCTTTCCTGTTGTCTGCCACTCAAAGGGGC
CCAGCCCTGGTGGTGATCTTTGAGAGGTTGAGAACTGTCATTCCTGGATAGAACTCCCTTGATTGTCAGCTGTCCTCACAAAAGCAGAAC
ATTGTACAAAGTACTGAACAGGGTAACCTGGAAACAGACCTCTGTCTCCCTCAATTACTCAGCCAAGGTAAGCCCAGCCTGCTGGGTAAG

>91734_91734_6_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000451578_NDUFAB1_chr16_23598640_ENST00000570319_length(amino acids)=132AA_BP=32
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLD

--------------------------------------------------------------
>91734_91734_7_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000572258_NDUFAB1_chr16_23598640_ENST00000007516_length(transcript)=763nt_BP=280nt
TCTTTCCTTCTTCCTCTTGTTCCTCCTCCTGCCTCTCTTCGCTTCGCCTGCAAACGCGGTGGGGGCTGCTCGGCGGTCAGGAGCAGCAAG
AGACAGAGCGACATGAGAGATTGGACCGCGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAGATTGAAGTGAGCTT
CAGAATGGCAAAAGAGGAGCCCCAGAGTATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATAGACTCCTTCCAGAA
TAACTCAAAGGTTCCTGGTAGAGTTACACAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGCATCCAGGACCGTGT
TCTTTACGTATTGAAACTCTATGACAAGATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTGGGCTTAGACAGTTT
GGACCAAGTGGAGATTATCATGGCCATGGAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTAATGTGTCCACAAGA
AATTGTAGATTACATTGCAGATAAGAAGGATGTATATGAATAAAGTATCAGACCCTTTGGCTTTGCTGAGAGAGGACTCAGATGATAGTG
ACGAATGTCTGGCAGTGAGGACACATTTTGGCATTCTTGCTGACTCTGACAGAGTGATTCTGATGGACTTGTATTTAAATTGTATGTGTT

>91734_91734_7_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000572258_NDUFAB1_chr16_23598640_ENST00000007516_length(amino acids)=132AA_BP=32
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLD

--------------------------------------------------------------
>91734_91734_8_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000572258_NDUFAB1_chr16_23598640_ENST00000570319_length(transcript)=996nt_BP=280nt
TCTTTCCTTCTTCCTCTTGTTCCTCCTCCTGCCTCTCTTCGCTTCGCCTGCAAACGCGGTGGGGGCTGCTCGGCGGTCAGGAGCAGCAAG
AGACAGAGCGACATGAGAGATTGGACCGCGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAGATTGAAGTGAGCTT
CAGAATGGCAAAAGAGGAGCCCCAGAGTATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATAGACTCCTTCCAGAA
TAACTCAAAGGTTCCTGGTAGAGTTACACAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGCATCCAGGACCGTGT
TCTTTACGTATTGAAACTCTATGACAAGATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTGGGCTTAGACAGTTT
GGACCAAGTGGAGATTATCATGGCCATGGAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTAATGTGTCCACAAGA
AATTGTAGATTACATTGCAGATAAGAAGGATGTATATGAATAAAGTATCAGGTAAATAGACTTAAAAAATGATGTTCACCCATAGATTTG
TCTGTGGTTCTTCAATAAAGGAAACTTAAGAAGAAACAGAAAATGGAAATGCTTGACCAAGATTTTTCACTACTTATAAAATGCAAGCCC
TTTCCTGTTGTCTGCCACTCAAAGGGGCCCAGCCCTGGTGGTGATCTTTGAGAGGTTGAGAACTGTCATTCCTGGATAGAACTCCCTTGA
TTGTCAGCTGTCCTCACAAAAGCAGAACATTGTACAAAGTACTGAACAGGGTAACCTGGAAACAGACCTCTGTCTCCCTCAATTACTCAG
CCAAGGTAAGCCCAGCCTGCTGGGTAAGACACTGAAGTGACCTGGCTCTTAAGTAGGCAAGAGAGGCCTCATGTATAAGAGGATGGACTT

>91734_91734_8_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000572258_NDUFAB1_chr16_23598640_ENST00000570319_length(amino acids)=132AA_BP=32
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLD

--------------------------------------------------------------
>91734_91734_9_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000572599_NDUFAB1_chr16_23598640_ENST00000007516_length(transcript)=750nt_BP=267nt
CGCCTGCAAACGCGGTGGGGGCTGCTCGGCGGTCAGGAGCAGGTTACCCTCCGTCTGCATGCCCACCATCAAGCAAGAGACAGAGCGACA
TGAGAGATTGGACCGCGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAGATTGAAGTGAGCTTCAGAATGGCAAAA
GAGGAGCCCCAGAGTATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATAGACTCCTTCCAGAATAACTCAAAGGTT
CCTGGTAGAGTTACACAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGCATCCAGGACCGTGTTCTTTACGTATTG
AAACTCTATGACAAGATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTGGGCTTAGACAGTTTGGACCAAGTGGAG
ATTATCATGGCCATGGAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTAATGTGTCCACAAGAAATTGTAGATTAC
ATTGCAGATAAGAAGGATGTATATGAATAAAGTATCAGACCCTTTGGCTTTGCTGAGAGAGGACTCAGATGATAGTGACGAATGTCTGGC
AGTGAGGACACATTTTGGCATTCTTGCTGACTCTGACAGAGTGATTCTGATGGACTTGTATTTAAATTGTATGTGTTTTACTCTTTGAAA

>91734_91734_9_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000572599_NDUFAB1_chr16_23598640_ENST00000007516_length(amino acids)=132AA_BP=32
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLD

--------------------------------------------------------------
>91734_91734_10_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000572599_NDUFAB1_chr16_23598640_ENST00000570319_length(transcript)=983nt_BP=267nt
CGCCTGCAAACGCGGTGGGGGCTGCTCGGCGGTCAGGAGCAGGTTACCCTCCGTCTGCATGCCCACCATCAAGCAAGAGACAGAGCGACA
TGAGAGATTGGACCGCGGGCTGCACTGGAGAATTTACTGGTAGGATAATTCATCCCTAAAGAGATTGAAGTGAGCTTCAGAATGGCAAAA
GAGGAGCCCCAGAGTATCTCAAGGGACTTGCAGGAACTGCAGAAGAAGCTGTCTCTGCTGATAGACTCCTTCCAGAATAACTCAAAGGTT
CCTGGTAGAGTTACACAGTTGTGCCGCCAGTATAGCGACATGCCTCCTTTGACGTTAGAGGGCATCCAGGACCGTGTTCTTTACGTATTG
AAACTCTATGACAAGATTGACCCAGAGAAGCTTTCAGTAAATTCTCATTTTATGAAAGACCTGGGCTTAGACAGTTTGGACCAAGTGGAG
ATTATCATGGCCATGGAAGACGAATTTGGGTTTGAAATTCCTGATATAGATGCTGAAAAGTTAATGTGTCCACAAGAAATTGTAGATTAC
ATTGCAGATAAGAAGGATGTATATGAATAAAGTATCAGGTAAATAGACTTAAAAAATGATGTTCACCCATAGATTTGTCTGTGGTTCTTC
AATAAAGGAAACTTAAGAAGAAACAGAAAATGGAAATGCTTGACCAAGATTTTTCACTACTTATAAAATGCAAGCCCTTTCCTGTTGTCT
GCCACTCAAAGGGGCCCAGCCCTGGTGGTGATCTTTGAGAGGTTGAGAACTGTCATTCCTGGATAGAACTCCCTTGATTGTCAGCTGTCC
TCACAAAAGCAGAACATTGTACAAAGTACTGAACAGGGTAACCTGGAAACAGACCTCTGTCTCCCTCAATTACTCAGCCAAGGTAAGCCC

>91734_91734_10_TMEM159-NDUFAB1_TMEM159_chr16_21172599_ENST00000572599_NDUFAB1_chr16_23598640_ENST00000570319_length(amino acids)=132AA_BP=32
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVPGRVTQLCRQYSDMPPLTLEGIQDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TMEM159-NDUFAB1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM159-NDUFAB1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TMEM159-NDUFAB1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source