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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM161A-KLHL26 (FusionGDB2 ID:91738)

Fusion Gene Summary for TMEM161A-KLHL26

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM161A-KLHL26
	Fusion gene ID: 91738
		Hgene	Tgene
	Gene symbol	TMEM161A	KLHL26
	Gene ID	54929	55295
	Gene name	transmembrane protein 161A	kelch like family member 26
	Synonyms	AROS-29	-
	Cytomap	19p13.11	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 161Aadaptive response to oxidative stress protein 29	kelch-like protein 26kelch-like 26
	Modification date	20200320	20200313
	UniProtAcc	.	Q53HC5
	Ensembl transtripts involved in fusion gene	ENST00000162044, ENST00000450333, ENST00000587583, ENST00000592147,	ENST00000596843, ENST00000595182, ENST00000599006, ENST00000300976,
Fusion gene scores	* DoF score	4 X 3 X 4=48	3 X 3 X 3=27
	# samples	4	4
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TMEM161A [Title/Abstract] AND KLHL26 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM161A(19249234)-KLHL26(18778473), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMEM161A	GO:0032526	response to retinoic acid	16551573
Hgene	TMEM161A	GO:0034599	cellular response to oxidative stress	16551573
Hgene	TMEM161A	GO:0034644	cellular response to UV	16551573

Fusion gene breakpoints across TMEM161A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KLHL26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CR-5250	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+

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Fusion Gene ORF analysis for TMEM161A-KLHL26

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000162044	ENST00000596843	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5CDS-3UTR	ENST00000450333	ENST00000596843	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5CDS-3UTR	ENST00000587583	ENST00000596843	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5CDS-intron	ENST00000162044	ENST00000595182	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5CDS-intron	ENST00000162044	ENST00000599006	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5CDS-intron	ENST00000450333	ENST00000595182	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5CDS-intron	ENST00000450333	ENST00000599006	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5CDS-intron	ENST00000587583	ENST00000595182	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5CDS-intron	ENST00000587583	ENST00000599006	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5UTR-3CDS	ENST00000592147	ENST00000300976	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5UTR-3UTR	ENST00000592147	ENST00000596843	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5UTR-intron	ENST00000592147	ENST00000595182	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
5UTR-intron	ENST00000592147	ENST00000599006	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
In-frame	ENST00000162044	ENST00000300976	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
In-frame	ENST00000450333	ENST00000300976	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+
In-frame	ENST00000587583	ENST00000300976	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000450333	TMEM161A	chr19	19249234	-	ENST00000300976	KLHL26	chr19	18778473	+	2877	41	45	1622	525
ENST00000162044	TMEM161A	chr19	19249234	-	ENST00000300976	KLHL26	chr19	18778473	+	2904	68	72	1649	525
ENST00000587583	TMEM161A	chr19	19249234	-	ENST00000300976	KLHL26	chr19	18778473	+	2858	22	26	1603	525

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000450333	ENST00000300976	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+	0.010749148	0.9892509
ENST00000162044	ENST00000300976	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+	0.010959731	0.98904026
ENST00000587583	ENST00000300976	TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+	0.010963408	0.9890366

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Fusion Genomic Features for TMEM161A-KLHL26

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+	2.81E-08	1
TMEM161A	chr19	19249234	-	KLHL26	chr19	18778473	+	2.81E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM161A-KLHL26

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:19249234/chr19:18778473)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	KLHL26 Q53HC5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KLHL26

chr19:19249234

chr19:18778473

ENST00000300976

165_266

616.0

Domain

Note=BACK

Tgene

KLHL26

chr19:19249234

chr19:18778473

ENST00000300976

310_361

616.0

Repeat

Note=Kelch 1

Tgene

KLHL26

chr19:19249234

chr19:18778473

ENST00000300976

362_413

616.0

Repeat

Note=Kelch 2

Tgene

KLHL26

chr19:19249234

chr19:18778473

ENST00000300976

414_460

616.0

Repeat

Note=Kelch 3

Tgene

KLHL26

chr19:19249234

chr19:18778473

ENST00000300976

461_508

616.0

Repeat

Note=Kelch 4

Tgene

KLHL26

chr19:19249234

chr19:18778473

ENST00000300976

510_559

616.0

Repeat

Note=Kelch 5

Tgene

KLHL26

chr19:19249234

chr19:18778473

ENST00000300976

561_608

616.0

Repeat

Note=Kelch 6

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

120_134

480.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

156_166

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

188_224

480.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

246_263

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

285_304

480.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

29_98

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

326_370

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

392_449

480.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

471_479

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

120_134

377.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

156_166

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

188_224

377.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

246_263

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

285_304

377.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

29_98

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

326_370

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

392_449

377.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

471_479

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

135_155

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

167_187

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

225_245

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

264_284

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

305_325

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

371_391

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

450_470

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000162044

99_119

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

135_155

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

167_187

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

225_245

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

264_284

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

305_325

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

371_391

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

450_470

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr19:18778473

ENST00000450333

99_119

377.0

Transmembrane

Helical

Tgene

KLHL26

chr19:19249234

chr19:18778473

ENST00000300976

63_130

616.0

Domain

BTB

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Fusion Gene Sequence for TMEM161A-KLHL26

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91738_91738_1_TMEM161A-KLHL26_TMEM161A_chr19_19249234_ENST00000162044_KLHL26_chr19_18778473_ENST00000300976_length(transcript)=2904nt_BP=68nt
GAGTTTCCGCAGAGTGCCCGGAGCCCTAGGCCGGTGGGTGAGTGCACCGCGTTCTCGCACGCGTCATGGGCCATGTTCACCGGCGGCATG
CGGGAGGCAAGCCAGGACGTCATCGAGCTGAAGGGCGTGTCGGCCCGTGGCCTGCGGCACATCATCGACTTCGCCTACAGCGCCGAGGTG
ACACTGGACCTGGACTGCGTGCAGGACGTGCTGGGCGCGGCCGTGTTCTTGCAGATGCTGCCCGTGGTGGAGCTGTGCGAGGAGTTCCTG
AAGGCGGCCATGAGCGTGGAGACCTGCCTCAACATCGGCCAGATGGCCACCACCTTCAGCCTGGCCTCGCTGCGAGAGTCGGTGGATGCC
TTCACCTTCCGGCACTTCCTGCAGATCGCCGAGGAGGAGGATTTCCTGCGCCTGCCACTGGAGCGCCTGGTCTTCTTCCTGCAGAGCAAC
CGGCTGCAGAGCTGTGCCGAGATCGACCTGTTCCGCGCGGCCGTCCGCTGGCTGCAGCATGACCCGGCCCGGCGGCCGCGCGCCAGCCAC
GTGCTCTGCCACATTCGCTTCCCGCTCATGCAGTCGTCCGAGCTGGTGGACAGCGTGCAGACGCTGGACATCATGGTGGAGGACGTGCTG
TGCCGCCAGTATCTGCTGGAGGCCTTCAACTACCAGGTGCTGCCCTTCCGGCAGCACGAGATGCAGTCTCCGCGCACCGCCGTGCGCTCG
GATGTGCCCTCGCTCGTCACCTTCGGCGGCACGCCCTACACCGACAGCGACCGCTCGGTCAGCAGCAAGGTCTACCAGCTGCCTGAGCCG
GGAGCCCGCCACTTCCGCGAGCTCACGGAGATGGAGGTAGGCTGCAGCCACACGTGCGTGGCCGTGCTGGACAATTTTGTGTACGTGGCC
GGGGGGCAGCACCTGCAGTACCGCAGCGGCGAGGGCGCAGTGGACGCCTGCTACCGCTACGACCCCCACCTGAATCGCTGGCTGCGCCTG
CAGGCCATGCAGGAAAGCCGCATCCAGTTCCAGCTGAACGTGCTGTGCGGCATGGTGTACGCCACGGGCGGCCGCAACCGAGCCGGCAGC
CTGGCCTCCGTGGAGCGGTACTGCCCCCGGCGCAATGAGTGGGGCTACGCCTGCTCGCTGAAGCGCCGTACCTGGGGCCATGCTGGGGCC
GCCTCAGGGGGCCGCCTCTACATCTCGGGTGGCTACGGGATCTCAGTGGAGGACAAGAAGGCCCTGCACTGCTACGACCCCGTGGCCGAC
CAGTGGGAGTTCAAGGCGCCCATGAGCGAACCCCGCGTGCTACACGCCATGGTGGGTGCCGGCGGCCGCATCTATGCCCTCGGGGGCCGC
ATGGACCACGTGGACCGCTGCTTCGACGTGCTGGCTGTGGAGTACTATGTGCCGGAGACGGACCAGTGGACCAGCGTGAGCCCCATGCGG
GCCGGCCAGTCAGAGGCCGGCTGCTGCCTGCTGGAGAGGAAGATCTACATCGTCGGGGGCTACAACTGGCGTCTCAACAACGTCACGGGC
ATCGTACAGGTGTACAACACGGACACCGACGAGTGGGAGCGGGACCTGCACTTCCCGGAGTCCTTCGCAGGCATAGCCTGCGCCCCCGTC
CTGCTGCCCCGGGCCGGGACCAGGAGGTAGCCCCCAAGACCCCCGGGACCCTGGCCTGACCGCATGTTGTCTCCAAGTGGGGCTTGGCGA
ATGCACGTCTGCCTGAGAACCCCAGTGCCCCCCTTCGCCCGGGCTGCCCTTGAGGGGCCTGCTGCGTTGATAAGCCCCCCTCCCAGGGGT
CCCTCCCTCCCTCCTTCCCAAAGCAGATCCTGGCTGCGAGTCCATCCGAGGGAGCCTGCCGGCAAAGCGTCTGACATGTGGTGGCAGCAA
ATTCGTCCCCGGGGTGGTTTCCTCGCCTGGCCCCCGAGTCCCCACGGGCTGGCGGGTGGAATCCCAGGTCTCCAGGGGGTCCCTGTGCAG
CTCCATCTCACTTCTCTACTGCCTCCCAGCCCCACGGTTTCAGGCATTCAGATGTGAGCTCATCAACATTGAACCCAAAGTCGGTGGTAT
ATGACTCACCCTCCTTCCAAGTCTCCTGCGCGCGTGTTTTTAAAATAAACTCACCCGAAACGTCCGTAACACACGGACCTCCAGGAGCAG
TGAGAGGTGGCTTAGAAGCCCCTGGTTTGGGGTGGGTGGAGGAGGAGGGCACGTGTCTGCCTCCCCTGGGGTGCCCTCCTTCCCCCATCC
CAAGCTGCTGAGGGGAGGCCCTGGTCATGCCTCAGTTCCTGCCTTCATCTGCTTTCCGGAGGAAAAACCATATCAACTCCTAGAAACGCT
CCTTAGGGGCTTGGGACCTTCCATTTGGCACTGAGCATCTTGTGGGGCCTTAACTGGCTGAGACATCCCGGCCCTCTACATTTGCCCTGT
TGGCCAGGCAGTCCCCTTCCCGCAATTGGAGGGCGACGCTAACTTCAGAATCCCATAGTGGCGCTTGCCGCAGGTCTGGTGGGGTGTCTT
TTTTCTCCTCCCTCCTTTCCACCCCTCCGCGCCCTGCCACTCCCTGGCCTGCCCTGTTTTTGGGTCAACATTGCTACGGAGCCAGCAGTG
AGGCCTTTCCCTTCAAGGGCTCTGTGGTATCTCTGGCCACATTTGTTCTAATGTCTGAACCTCTAAATCTTTTCTTTTTGATTGGTTTTA
CTGTTTTTAAGAAGCCAGCACTGCTGTCTCATAGATGGGATTTGTACTCTTGGGGCAACTTAAAGTGTCTCTCTCGCTGCTAACAGACGA
TTGATGTCTTGTCTCTGTGACCCACTCACCATGTAAAGAATTAACCTCCTATCTTAGCAGACATCGTCTCCTAATATTTCCCTTTATTTA

>91738_91738_1_TMEM161A-KLHL26_TMEM161A_chr19_19249234_ENST00000162044_KLHL26_chr19_18778473_ENST00000300976_length(amino acids)=525AA_BP=0
MFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASL
RESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDI
MVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLD
NFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRT
WGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWT

--------------------------------------------------------------
>91738_91738_2_TMEM161A-KLHL26_TMEM161A_chr19_19249234_ENST00000450333_KLHL26_chr19_18778473_ENST00000300976_length(transcript)=2877nt_BP=41nt
AGGCCGGTGGGTGAGTGCACCGCGTTCTCGCACGCGTCATGGGCCATGTTCACCGGCGGCATGCGGGAGGCAAGCCAGGACGTCATCGAG
CTGAAGGGCGTGTCGGCCCGTGGCCTGCGGCACATCATCGACTTCGCCTACAGCGCCGAGGTGACACTGGACCTGGACTGCGTGCAGGAC
GTGCTGGGCGCGGCCGTGTTCTTGCAGATGCTGCCCGTGGTGGAGCTGTGCGAGGAGTTCCTGAAGGCGGCCATGAGCGTGGAGACCTGC
CTCAACATCGGCCAGATGGCCACCACCTTCAGCCTGGCCTCGCTGCGAGAGTCGGTGGATGCCTTCACCTTCCGGCACTTCCTGCAGATC
GCCGAGGAGGAGGATTTCCTGCGCCTGCCACTGGAGCGCCTGGTCTTCTTCCTGCAGAGCAACCGGCTGCAGAGCTGTGCCGAGATCGAC
CTGTTCCGCGCGGCCGTCCGCTGGCTGCAGCATGACCCGGCCCGGCGGCCGCGCGCCAGCCACGTGCTCTGCCACATTCGCTTCCCGCTC
ATGCAGTCGTCCGAGCTGGTGGACAGCGTGCAGACGCTGGACATCATGGTGGAGGACGTGCTGTGCCGCCAGTATCTGCTGGAGGCCTTC
AACTACCAGGTGCTGCCCTTCCGGCAGCACGAGATGCAGTCTCCGCGCACCGCCGTGCGCTCGGATGTGCCCTCGCTCGTCACCTTCGGC
GGCACGCCCTACACCGACAGCGACCGCTCGGTCAGCAGCAAGGTCTACCAGCTGCCTGAGCCGGGAGCCCGCCACTTCCGCGAGCTCACG
GAGATGGAGGTAGGCTGCAGCCACACGTGCGTGGCCGTGCTGGACAATTTTGTGTACGTGGCCGGGGGGCAGCACCTGCAGTACCGCAGC
GGCGAGGGCGCAGTGGACGCCTGCTACCGCTACGACCCCCACCTGAATCGCTGGCTGCGCCTGCAGGCCATGCAGGAAAGCCGCATCCAG
TTCCAGCTGAACGTGCTGTGCGGCATGGTGTACGCCACGGGCGGCCGCAACCGAGCCGGCAGCCTGGCCTCCGTGGAGCGGTACTGCCCC
CGGCGCAATGAGTGGGGCTACGCCTGCTCGCTGAAGCGCCGTACCTGGGGCCATGCTGGGGCCGCCTCAGGGGGCCGCCTCTACATCTCG
GGTGGCTACGGGATCTCAGTGGAGGACAAGAAGGCCCTGCACTGCTACGACCCCGTGGCCGACCAGTGGGAGTTCAAGGCGCCCATGAGC
GAACCCCGCGTGCTACACGCCATGGTGGGTGCCGGCGGCCGCATCTATGCCCTCGGGGGCCGCATGGACCACGTGGACCGCTGCTTCGAC
GTGCTGGCTGTGGAGTACTATGTGCCGGAGACGGACCAGTGGACCAGCGTGAGCCCCATGCGGGCCGGCCAGTCAGAGGCCGGCTGCTGC
CTGCTGGAGAGGAAGATCTACATCGTCGGGGGCTACAACTGGCGTCTCAACAACGTCACGGGCATCGTACAGGTGTACAACACGGACACC
GACGAGTGGGAGCGGGACCTGCACTTCCCGGAGTCCTTCGCAGGCATAGCCTGCGCCCCCGTCCTGCTGCCCCGGGCCGGGACCAGGAGG
TAGCCCCCAAGACCCCCGGGACCCTGGCCTGACCGCATGTTGTCTCCAAGTGGGGCTTGGCGAATGCACGTCTGCCTGAGAACCCCAGTG
CCCCCCTTCGCCCGGGCTGCCCTTGAGGGGCCTGCTGCGTTGATAAGCCCCCCTCCCAGGGGTCCCTCCCTCCCTCCTTCCCAAAGCAGA
TCCTGGCTGCGAGTCCATCCGAGGGAGCCTGCCGGCAAAGCGTCTGACATGTGGTGGCAGCAAATTCGTCCCCGGGGTGGTTTCCTCGCC
TGGCCCCCGAGTCCCCACGGGCTGGCGGGTGGAATCCCAGGTCTCCAGGGGGTCCCTGTGCAGCTCCATCTCACTTCTCTACTGCCTCCC
AGCCCCACGGTTTCAGGCATTCAGATGTGAGCTCATCAACATTGAACCCAAAGTCGGTGGTATATGACTCACCCTCCTTCCAAGTCTCCT
GCGCGCGTGTTTTTAAAATAAACTCACCCGAAACGTCCGTAACACACGGACCTCCAGGAGCAGTGAGAGGTGGCTTAGAAGCCCCTGGTT
TGGGGTGGGTGGAGGAGGAGGGCACGTGTCTGCCTCCCCTGGGGTGCCCTCCTTCCCCCATCCCAAGCTGCTGAGGGGAGGCCCTGGTCA
TGCCTCAGTTCCTGCCTTCATCTGCTTTCCGGAGGAAAAACCATATCAACTCCTAGAAACGCTCCTTAGGGGCTTGGGACCTTCCATTTG
GCACTGAGCATCTTGTGGGGCCTTAACTGGCTGAGACATCCCGGCCCTCTACATTTGCCCTGTTGGCCAGGCAGTCCCCTTCCCGCAATT
GGAGGGCGACGCTAACTTCAGAATCCCATAGTGGCGCTTGCCGCAGGTCTGGTGGGGTGTCTTTTTTCTCCTCCCTCCTTTCCACCCCTC
CGCGCCCTGCCACTCCCTGGCCTGCCCTGTTTTTGGGTCAACATTGCTACGGAGCCAGCAGTGAGGCCTTTCCCTTCAAGGGCTCTGTGG
TATCTCTGGCCACATTTGTTCTAATGTCTGAACCTCTAAATCTTTTCTTTTTGATTGGTTTTACTGTTTTTAAGAAGCCAGCACTGCTGT
CTCATAGATGGGATTTGTACTCTTGGGGCAACTTAAAGTGTCTCTCTCGCTGCTAACAGACGATTGATGTCTTGTCTCTGTGACCCACTC

>91738_91738_2_TMEM161A-KLHL26_TMEM161A_chr19_19249234_ENST00000450333_KLHL26_chr19_18778473_ENST00000300976_length(amino acids)=525AA_BP=0
MFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASL
RESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDI
MVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLD
NFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRT
WGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWT

--------------------------------------------------------------
>91738_91738_3_TMEM161A-KLHL26_TMEM161A_chr19_19249234_ENST00000587583_KLHL26_chr19_18778473_ENST00000300976_length(transcript)=2858nt_BP=22nt
CCGCGTTCTCGCACGCGTCATGGGCCATGTTCACCGGCGGCATGCGGGAGGCAAGCCAGGACGTCATCGAGCTGAAGGGCGTGTCGGCCC
GTGGCCTGCGGCACATCATCGACTTCGCCTACAGCGCCGAGGTGACACTGGACCTGGACTGCGTGCAGGACGTGCTGGGCGCGGCCGTGT
TCTTGCAGATGCTGCCCGTGGTGGAGCTGTGCGAGGAGTTCCTGAAGGCGGCCATGAGCGTGGAGACCTGCCTCAACATCGGCCAGATGG
CCACCACCTTCAGCCTGGCCTCGCTGCGAGAGTCGGTGGATGCCTTCACCTTCCGGCACTTCCTGCAGATCGCCGAGGAGGAGGATTTCC
TGCGCCTGCCACTGGAGCGCCTGGTCTTCTTCCTGCAGAGCAACCGGCTGCAGAGCTGTGCCGAGATCGACCTGTTCCGCGCGGCCGTCC
GCTGGCTGCAGCATGACCCGGCCCGGCGGCCGCGCGCCAGCCACGTGCTCTGCCACATTCGCTTCCCGCTCATGCAGTCGTCCGAGCTGG
TGGACAGCGTGCAGACGCTGGACATCATGGTGGAGGACGTGCTGTGCCGCCAGTATCTGCTGGAGGCCTTCAACTACCAGGTGCTGCCCT
TCCGGCAGCACGAGATGCAGTCTCCGCGCACCGCCGTGCGCTCGGATGTGCCCTCGCTCGTCACCTTCGGCGGCACGCCCTACACCGACA
GCGACCGCTCGGTCAGCAGCAAGGTCTACCAGCTGCCTGAGCCGGGAGCCCGCCACTTCCGCGAGCTCACGGAGATGGAGGTAGGCTGCA
GCCACACGTGCGTGGCCGTGCTGGACAATTTTGTGTACGTGGCCGGGGGGCAGCACCTGCAGTACCGCAGCGGCGAGGGCGCAGTGGACG
CCTGCTACCGCTACGACCCCCACCTGAATCGCTGGCTGCGCCTGCAGGCCATGCAGGAAAGCCGCATCCAGTTCCAGCTGAACGTGCTGT
GCGGCATGGTGTACGCCACGGGCGGCCGCAACCGAGCCGGCAGCCTGGCCTCCGTGGAGCGGTACTGCCCCCGGCGCAATGAGTGGGGCT
ACGCCTGCTCGCTGAAGCGCCGTACCTGGGGCCATGCTGGGGCCGCCTCAGGGGGCCGCCTCTACATCTCGGGTGGCTACGGGATCTCAG
TGGAGGACAAGAAGGCCCTGCACTGCTACGACCCCGTGGCCGACCAGTGGGAGTTCAAGGCGCCCATGAGCGAACCCCGCGTGCTACACG
CCATGGTGGGTGCCGGCGGCCGCATCTATGCCCTCGGGGGCCGCATGGACCACGTGGACCGCTGCTTCGACGTGCTGGCTGTGGAGTACT
ATGTGCCGGAGACGGACCAGTGGACCAGCGTGAGCCCCATGCGGGCCGGCCAGTCAGAGGCCGGCTGCTGCCTGCTGGAGAGGAAGATCT
ACATCGTCGGGGGCTACAACTGGCGTCTCAACAACGTCACGGGCATCGTACAGGTGTACAACACGGACACCGACGAGTGGGAGCGGGACC
TGCACTTCCCGGAGTCCTTCGCAGGCATAGCCTGCGCCCCCGTCCTGCTGCCCCGGGCCGGGACCAGGAGGTAGCCCCCAAGACCCCCGG
GACCCTGGCCTGACCGCATGTTGTCTCCAAGTGGGGCTTGGCGAATGCACGTCTGCCTGAGAACCCCAGTGCCCCCCTTCGCCCGGGCTG
CCCTTGAGGGGCCTGCTGCGTTGATAAGCCCCCCTCCCAGGGGTCCCTCCCTCCCTCCTTCCCAAAGCAGATCCTGGCTGCGAGTCCATC
CGAGGGAGCCTGCCGGCAAAGCGTCTGACATGTGGTGGCAGCAAATTCGTCCCCGGGGTGGTTTCCTCGCCTGGCCCCCGAGTCCCCACG
GGCTGGCGGGTGGAATCCCAGGTCTCCAGGGGGTCCCTGTGCAGCTCCATCTCACTTCTCTACTGCCTCCCAGCCCCACGGTTTCAGGCA
TTCAGATGTGAGCTCATCAACATTGAACCCAAAGTCGGTGGTATATGACTCACCCTCCTTCCAAGTCTCCTGCGCGCGTGTTTTTAAAAT
AAACTCACCCGAAACGTCCGTAACACACGGACCTCCAGGAGCAGTGAGAGGTGGCTTAGAAGCCCCTGGTTTGGGGTGGGTGGAGGAGGA
GGGCACGTGTCTGCCTCCCCTGGGGTGCCCTCCTTCCCCCATCCCAAGCTGCTGAGGGGAGGCCCTGGTCATGCCTCAGTTCCTGCCTTC
ATCTGCTTTCCGGAGGAAAAACCATATCAACTCCTAGAAACGCTCCTTAGGGGCTTGGGACCTTCCATTTGGCACTGAGCATCTTGTGGG
GCCTTAACTGGCTGAGACATCCCGGCCCTCTACATTTGCCCTGTTGGCCAGGCAGTCCCCTTCCCGCAATTGGAGGGCGACGCTAACTTC
AGAATCCCATAGTGGCGCTTGCCGCAGGTCTGGTGGGGTGTCTTTTTTCTCCTCCCTCCTTTCCACCCCTCCGCGCCCTGCCACTCCCTG
GCCTGCCCTGTTTTTGGGTCAACATTGCTACGGAGCCAGCAGTGAGGCCTTTCCCTTCAAGGGCTCTGTGGTATCTCTGGCCACATTTGT
TCTAATGTCTGAACCTCTAAATCTTTTCTTTTTGATTGGTTTTACTGTTTTTAAGAAGCCAGCACTGCTGTCTCATAGATGGGATTTGTA
CTCTTGGGGCAACTTAAAGTGTCTCTCTCGCTGCTAACAGACGATTGATGTCTTGTCTCTGTGACCCACTCACCATGTAAAGAATTAACC

>91738_91738_3_TMEM161A-KLHL26_TMEM161A_chr19_19249234_ENST00000587583_KLHL26_chr19_18778473_ENST00000300976_length(amino acids)=525AA_BP=0
MFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASL
RESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDI
MVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLD
NFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRT
WGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TMEM161A-KLHL26

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM161A-KLHL26

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TMEM161A-KLHL26

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source