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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:TMEM161A-PCDH1 (FusionGDB2 ID:91739)

Fusion Gene Summary for TMEM161A-PCDH1

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM161A-PCDH1
	Fusion gene ID: 91739
		Hgene	Tgene
	Gene symbol	TMEM161A	PCDH1
	Gene ID	54929	5097
	Gene name	transmembrane protein 161A	protocadherin 1
	Synonyms	AROS-29	PC42\|PCDH42
	Cytomap	19p13.11	5q31.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 161Aadaptive response to oxidative stress protein 29	protocadherin-1cadherin-like 1cadherin-like protein 1protocadherin 42
	Modification date	20200320	20200320
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000162044, ENST00000450333, ENST00000587583, ENST00000592147,	ENST00000536585, ENST00000511044, ENST00000287008, ENST00000394536, ENST00000456271, ENST00000503492,
Fusion gene scores	* DoF score	4 X 3 X 4=48	3 X 3 X 2=18
	# samples	4	3
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TMEM161A [Title/Abstract] AND PCDH1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM161A(19249234)-PCDH1(141248996), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TMEM161A	GO:0032526	response to retinoic acid	16551573
Hgene	TMEM161A	GO:0034599	cellular response to oxidative stress	16551573
Hgene	TMEM161A	GO:0034644	cellular response to UV	16551573

Fusion gene breakpoints across TMEM161A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PCDH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-B6-A0WY	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-

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Fusion Gene ORF analysis for TMEM161A-PCDH1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000162044	ENST00000536585	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5CDS-5UTR	ENST00000450333	ENST00000536585	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5CDS-5UTR	ENST00000587583	ENST00000536585	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5CDS-intron	ENST00000162044	ENST00000511044	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5CDS-intron	ENST00000450333	ENST00000511044	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5CDS-intron	ENST00000587583	ENST00000511044	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5UTR-3CDS	ENST00000592147	ENST00000287008	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5UTR-3CDS	ENST00000592147	ENST00000394536	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5UTR-3CDS	ENST00000592147	ENST00000456271	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5UTR-3CDS	ENST00000592147	ENST00000503492	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5UTR-5UTR	ENST00000592147	ENST00000536585	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
5UTR-intron	ENST00000592147	ENST00000511044	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
Frame-shift	ENST00000162044	ENST00000287008	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
Frame-shift	ENST00000162044	ENST00000394536	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
Frame-shift	ENST00000162044	ENST00000456271	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
Frame-shift	ENST00000450333	ENST00000287008	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
Frame-shift	ENST00000450333	ENST00000394536	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
Frame-shift	ENST00000450333	ENST00000456271	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
Frame-shift	ENST00000587583	ENST00000287008	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
Frame-shift	ENST00000587583	ENST00000394536	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
Frame-shift	ENST00000587583	ENST00000456271	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
In-frame	ENST00000162044	ENST00000503492	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
In-frame	ENST00000450333	ENST00000503492	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-
In-frame	ENST00000587583	ENST00000503492	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000450333	TMEM161A	chr19	19249234	-	ENST00000503492	PCDH1	chr5	141248996	-	2227	41	46	1149	367
ENST00000162044	TMEM161A	chr19	19249234	-	ENST00000503492	PCDH1	chr5	141248996	-	2254	68	73	1176	367
ENST00000587583	TMEM161A	chr19	19249234	-	ENST00000503492	PCDH1	chr5	141248996	-	2208	22	27	1130	367

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000450333	ENST00000503492	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-	0.006183283	0.9938167
ENST00000162044	ENST00000503492	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-	0.006350105	0.9936499
ENST00000587583	ENST00000503492	TMEM161A	chr19	19249234	-	PCDH1	chr5	141248996	-	0.006073416	0.9939266

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Fusion Genomic Features for TMEM161A-PCDH1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM161A-PCDH1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:19249234/chr5:141248996)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

169_280

1238.0

Domain

Cadherin 2

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

281_387

1238.0

Domain

Cadherin 3

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

396_506

1238.0

Domain

Cadherin 4

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

507_612

1238.0

Domain

Cadherin 5

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

58_168

1238.0

Domain

Cadherin 1

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

613_715

1238.0

Domain

Cadherin 6

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

718_844

1238.0

Domain

Cadherin 7

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

169_280

1061.0

Domain

Cadherin 2

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

281_387

1061.0

Domain

Cadherin 3

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

396_506

1061.0

Domain

Cadherin 4

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

507_612

1061.0

Domain

Cadherin 5

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

58_168

1061.0

Domain

Cadherin 1

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

613_715

1061.0

Domain

Cadherin 6

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

718_844

1061.0

Domain

Cadherin 7

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

169_280

1049.0

Domain

Cadherin 2

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

281_387

1049.0

Domain

Cadherin 3

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

396_506

1049.0

Domain

Cadherin 4

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

507_612

1049.0

Domain

Cadherin 5

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

58_168

1049.0

Domain

Cadherin 1

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

613_715

1049.0

Domain

Cadherin 6

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

718_844

1049.0

Domain

Cadherin 7

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

58_852

1238.0

Topological domain

Extracellular

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

874_1060

1238.0

Topological domain

Cytoplasmic

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

58_852

1061.0

Topological domain

Extracellular

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

874_1060

1061.0

Topological domain

Cytoplasmic

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

58_852

1049.0

Topological domain

Extracellular

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

874_1060

1049.0

Topological domain

Cytoplasmic

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000287008

853_873

1238.0

Transmembrane

Helical

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000394536

853_873

1061.0

Transmembrane

Helical

Tgene

PCDH1

chr19:19249234

chr5:141248996

ENST00000456271

853_873

1049.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

120_134

480.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

156_166

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

188_224

480.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

246_263

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

285_304

480.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

29_98

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

326_370

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

392_449

480.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

471_479

480.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

120_134

377.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

156_166

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

188_224

377.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

246_263

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

285_304

377.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

29_98

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

326_370

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

392_449

377.0

Topological domain

Cytoplasmic

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

471_479

377.0

Topological domain

Extracellular

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

135_155

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

167_187

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

225_245

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

264_284

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

305_325

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

371_391

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

450_470

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000162044

99_119

480.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

135_155

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

167_187

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

225_245

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

264_284

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

305_325

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

371_391

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

450_470

377.0

Transmembrane

Helical

Hgene

TMEM161A

chr19:19249234

chr5:141248996

ENST00000450333

99_119

377.0

Transmembrane

Helical

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Fusion Gene Sequence for TMEM161A-PCDH1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91739_91739_1_TMEM161A-PCDH1_TMEM161A_chr19_19249234_ENST00000162044_PCDH1_chr5_141248996_ENST00000503492_length(transcript)=2254nt_BP=68nt
GAGTTTCCGCAGAGTGCCCGGAGCCCTAGGCCGGTGGGTGAGTGCACCGCGTTCTCGCACGCGTCATGCCCTCCTGATTCTGGGGCCTCC
CAGGATGGAGCACCTGAGGCACAGCCCAGGCCCTGGGGGGCAACGGCTACTGCTGCCCTCCATGCTGCTAGCACTGCTGCTCCTGCTGGC
TCCATCCCCAGGCCACGCCACTCGGGTAGTGTACAAGGTGCCGGAGGAACAGCCACCCAACACCCTCATTGGGAGCCTCGCAGCCGACTA
TGGTTTTCCAGATGTGGGGCACCTGTACAAGCTAGAGGTGGGTGCCCCGTACCTTCGCGTGGATGGCAAGACAGGTGACATTTTCACCAC
CGAGACCTCCATCGACCGTGAGGGGCTCCGTGAATGCCAGAACCAGCTCCCTGGTGATCCCTGCATCCTGGAGTTTGAGGTATCTATCAC
AGACCTCGTGCAGAATGGCAGCCCCCGGCTGCTAGAGGGCCAGATAGAAGTACAAGACATCAATGACAACACACCCAACTTCGCCTCACC
AGTCATCACTCTGGCCATCCCTGAGAACACCAACATCGGCTCACTCTTCCCCATCCCGCTGGCTTCAGACCGTGATGCTGGTCCCAACGG
TGTGGCATCCTATGAGCTGCAGGCTGGGCCTGAGGCCCAGGAGCTATTTGGGCTGCAGGTGGCAGAGGACCAGGAGGAGAAGCAACCACA
GCTCATTGTGATGGGCAACCTGGACCGTGAGCGCTGGGACTCCTATGACCTCACCATCAAGGTGCAGGATGGCGGCAGCCCCCCACGCGC
CAGCAGTGCCCTGCTGCGTGTCACCGTGCTTGACACCAATGACAACGCCCCCAAGTTTGAGCGGCCCTCCTATGAGGCCGAACTATCTGA
GAATAGCCCCATAGGCCACTCGGTCATCCAGTTACCTCACCGCCGCGTCACCTTCTCGGCCACCAGCCAGGCCCAGGAGCTGCAGGACCC
ATCCCAGCACAGTTACTATGACAGTGGCCTGGAGGAGTCTGAGACGCCGTCCAGCAAGTCATCCTCAGGGCCTCGACTCGGTCCCCTGGC
CCTGCCTGAGGATCACTATGAGCGCACCACCCCTGATGGCAGCATAGGAGAGATGGAGCACCCCGAGAATGAGCCGGCTGGCCGGAGCAG
GCCCTGAGGCAGAGTGCCAGACCTTCGCCCTTTGCCTGATGTCGCCATGACAGGCACATGTACCCGGGAGTGCAGTGAGTTTGGCCACTC
TGACACATGCTGGATGCCTGGCCAGTCATCTCCCAGCCGCCGGACCAAGAGCAGCGCCCTCAAACTCTCCACCTTCGTGCCTTACCAGGA
CCGAGGAGGGCAGGAGCCTGCGGGCGCCGGCAGCCCCAGCCCCCCGGAAGACCGGAACACCAAAACGGCCCCCGTGCGCCTCCTGCCCTC
CTACAGTGCCTTCTCCCACAGTAGCCATGATTCCTGCAAGGACTCGGCCACCTTGGAGGAAATCCCCCTGACCCAGACCTCGGACTTCCC
ACCCGCAGCCACACCGGCATCTGCCCAGACGGCCAAGCGCGAGATCTACCTGTGAGCCCCCTACTGGCCGGCCGGCCCCCCTCCCCCAGC
CGCCGGCCAGCTCCCAAATGGCCCATTCCAGGGCCTCACTCTCCACCCCTTCAGCGTGGACTTCCTGGCCAGGGCCCCAAGTGGGGGTAT
CACTGACCTCATGACCACGCTGGCCCTTCTCCCATGCAGGGTCCAGGTCCTCTCCCCTCATTTCCATCTCCCAGCCCCCAGGGGCCCCTT
CCCCTTTATGGGGCTTCCCCCATCTGATGCCCAAGAGGGCTCCTCTGCAATGACTGGGCTCCTTCCCTTGACTTCCAGGGAGCACCCCCT
CGATTTGGGCAGATGGTGGAGTCAAGGGTGGGCAGCGTACTTCTAACTCATTGTTTCCCTCATGGCCGACCAGGGCGGGGATAGCATGCC
CAATTTTAGCCCTGAAGCAGGGCTGAACTGGGGAGCCCCTTTCCCTGGGAGCTCCCAGAGGAAACTCTTGACCACCAGTGGCTCCCTGAA
GGGCTTTTGTTACCAAAGGTGGGGTAGGGACGGGGGTGGGAGTGGAGCGGAGGCCTTGTTTTCCCGTGCTGCTCCTGGACTGGCCCACCT
GCCTGCCACATGCCCACGCCTAGTCCCATCTGGGCCCCCATTCCCTGCTGGTCATGCAGTGTCTGTATATAAGGACCTTGGAATGACGTC

>91739_91739_1_TMEM161A-PCDH1_TMEM161A_chr19_19249234_ENST00000162044_PCDH1_chr5_141248996_ENST00000503492_length(amino acids)=367AA_BP=
MILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKT
GDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDR
DAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSY
EAELSENSPIGHSVIQLPHRRVTFSATSQAQELQDPSQHSYYDSGLEESETPSSKSSSGPRLGPLALPEDHYERTTPDGSIGEMEHPENE

--------------------------------------------------------------
>91739_91739_2_TMEM161A-PCDH1_TMEM161A_chr19_19249234_ENST00000450333_PCDH1_chr5_141248996_ENST00000503492_length(transcript)=2227nt_BP=41nt
AGGCCGGTGGGTGAGTGCACCGCGTTCTCGCACGCGTCATGCCCTCCTGATTCTGGGGCCTCCCAGGATGGAGCACCTGAGGCACAGCCC
AGGCCCTGGGGGGCAACGGCTACTGCTGCCCTCCATGCTGCTAGCACTGCTGCTCCTGCTGGCTCCATCCCCAGGCCACGCCACTCGGGT
AGTGTACAAGGTGCCGGAGGAACAGCCACCCAACACCCTCATTGGGAGCCTCGCAGCCGACTATGGTTTTCCAGATGTGGGGCACCTGTA
CAAGCTAGAGGTGGGTGCCCCGTACCTTCGCGTGGATGGCAAGACAGGTGACATTTTCACCACCGAGACCTCCATCGACCGTGAGGGGCT
CCGTGAATGCCAGAACCAGCTCCCTGGTGATCCCTGCATCCTGGAGTTTGAGGTATCTATCACAGACCTCGTGCAGAATGGCAGCCCCCG
GCTGCTAGAGGGCCAGATAGAAGTACAAGACATCAATGACAACACACCCAACTTCGCCTCACCAGTCATCACTCTGGCCATCCCTGAGAA
CACCAACATCGGCTCACTCTTCCCCATCCCGCTGGCTTCAGACCGTGATGCTGGTCCCAACGGTGTGGCATCCTATGAGCTGCAGGCTGG
GCCTGAGGCCCAGGAGCTATTTGGGCTGCAGGTGGCAGAGGACCAGGAGGAGAAGCAACCACAGCTCATTGTGATGGGCAACCTGGACCG
TGAGCGCTGGGACTCCTATGACCTCACCATCAAGGTGCAGGATGGCGGCAGCCCCCCACGCGCCAGCAGTGCCCTGCTGCGTGTCACCGT
GCTTGACACCAATGACAACGCCCCCAAGTTTGAGCGGCCCTCCTATGAGGCCGAACTATCTGAGAATAGCCCCATAGGCCACTCGGTCAT
CCAGTTACCTCACCGCCGCGTCACCTTCTCGGCCACCAGCCAGGCCCAGGAGCTGCAGGACCCATCCCAGCACAGTTACTATGACAGTGG
CCTGGAGGAGTCTGAGACGCCGTCCAGCAAGTCATCCTCAGGGCCTCGACTCGGTCCCCTGGCCCTGCCTGAGGATCACTATGAGCGCAC
CACCCCTGATGGCAGCATAGGAGAGATGGAGCACCCCGAGAATGAGCCGGCTGGCCGGAGCAGGCCCTGAGGCAGAGTGCCAGACCTTCG
CCCTTTGCCTGATGTCGCCATGACAGGCACATGTACCCGGGAGTGCAGTGAGTTTGGCCACTCTGACACATGCTGGATGCCTGGCCAGTC
ATCTCCCAGCCGCCGGACCAAGAGCAGCGCCCTCAAACTCTCCACCTTCGTGCCTTACCAGGACCGAGGAGGGCAGGAGCCTGCGGGCGC
CGGCAGCCCCAGCCCCCCGGAAGACCGGAACACCAAAACGGCCCCCGTGCGCCTCCTGCCCTCCTACAGTGCCTTCTCCCACAGTAGCCA
TGATTCCTGCAAGGACTCGGCCACCTTGGAGGAAATCCCCCTGACCCAGACCTCGGACTTCCCACCCGCAGCCACACCGGCATCTGCCCA
GACGGCCAAGCGCGAGATCTACCTGTGAGCCCCCTACTGGCCGGCCGGCCCCCCTCCCCCAGCCGCCGGCCAGCTCCCAAATGGCCCATT
CCAGGGCCTCACTCTCCACCCCTTCAGCGTGGACTTCCTGGCCAGGGCCCCAAGTGGGGGTATCACTGACCTCATGACCACGCTGGCCCT
TCTCCCATGCAGGGTCCAGGTCCTCTCCCCTCATTTCCATCTCCCAGCCCCCAGGGGCCCCTTCCCCTTTATGGGGCTTCCCCCATCTGA
TGCCCAAGAGGGCTCCTCTGCAATGACTGGGCTCCTTCCCTTGACTTCCAGGGAGCACCCCCTCGATTTGGGCAGATGGTGGAGTCAAGG
GTGGGCAGCGTACTTCTAACTCATTGTTTCCCTCATGGCCGACCAGGGCGGGGATAGCATGCCCAATTTTAGCCCTGAAGCAGGGCTGAA
CTGGGGAGCCCCTTTCCCTGGGAGCTCCCAGAGGAAACTCTTGACCACCAGTGGCTCCCTGAAGGGCTTTTGTTACCAAAGGTGGGGTAG
GGACGGGGGTGGGAGTGGAGCGGAGGCCTTGTTTTCCCGTGCTGCTCCTGGACTGGCCCACCTGCCTGCCACATGCCCACGCCTAGTCCC

>91739_91739_2_TMEM161A-PCDH1_TMEM161A_chr19_19249234_ENST00000450333_PCDH1_chr5_141248996_ENST00000503492_length(amino acids)=367AA_BP=
MILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKT
GDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDR
DAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSY
EAELSENSPIGHSVIQLPHRRVTFSATSQAQELQDPSQHSYYDSGLEESETPSSKSSSGPRLGPLALPEDHYERTTPDGSIGEMEHPENE

--------------------------------------------------------------
>91739_91739_3_TMEM161A-PCDH1_TMEM161A_chr19_19249234_ENST00000587583_PCDH1_chr5_141248996_ENST00000503492_length(transcript)=2208nt_BP=22nt
CCGCGTTCTCGCACGCGTCATGCCCTCCTGATTCTGGGGCCTCCCAGGATGGAGCACCTGAGGCACAGCCCAGGCCCTGGGGGGCAACGG
CTACTGCTGCCCTCCATGCTGCTAGCACTGCTGCTCCTGCTGGCTCCATCCCCAGGCCACGCCACTCGGGTAGTGTACAAGGTGCCGGAG
GAACAGCCACCCAACACCCTCATTGGGAGCCTCGCAGCCGACTATGGTTTTCCAGATGTGGGGCACCTGTACAAGCTAGAGGTGGGTGCC
CCGTACCTTCGCGTGGATGGCAAGACAGGTGACATTTTCACCACCGAGACCTCCATCGACCGTGAGGGGCTCCGTGAATGCCAGAACCAG
CTCCCTGGTGATCCCTGCATCCTGGAGTTTGAGGTATCTATCACAGACCTCGTGCAGAATGGCAGCCCCCGGCTGCTAGAGGGCCAGATA
GAAGTACAAGACATCAATGACAACACACCCAACTTCGCCTCACCAGTCATCACTCTGGCCATCCCTGAGAACACCAACATCGGCTCACTC
TTCCCCATCCCGCTGGCTTCAGACCGTGATGCTGGTCCCAACGGTGTGGCATCCTATGAGCTGCAGGCTGGGCCTGAGGCCCAGGAGCTA
TTTGGGCTGCAGGTGGCAGAGGACCAGGAGGAGAAGCAACCACAGCTCATTGTGATGGGCAACCTGGACCGTGAGCGCTGGGACTCCTAT
GACCTCACCATCAAGGTGCAGGATGGCGGCAGCCCCCCACGCGCCAGCAGTGCCCTGCTGCGTGTCACCGTGCTTGACACCAATGACAAC
GCCCCCAAGTTTGAGCGGCCCTCCTATGAGGCCGAACTATCTGAGAATAGCCCCATAGGCCACTCGGTCATCCAGTTACCTCACCGCCGC
GTCACCTTCTCGGCCACCAGCCAGGCCCAGGAGCTGCAGGACCCATCCCAGCACAGTTACTATGACAGTGGCCTGGAGGAGTCTGAGACG
CCGTCCAGCAAGTCATCCTCAGGGCCTCGACTCGGTCCCCTGGCCCTGCCTGAGGATCACTATGAGCGCACCACCCCTGATGGCAGCATA
GGAGAGATGGAGCACCCCGAGAATGAGCCGGCTGGCCGGAGCAGGCCCTGAGGCAGAGTGCCAGACCTTCGCCCTTTGCCTGATGTCGCC
ATGACAGGCACATGTACCCGGGAGTGCAGTGAGTTTGGCCACTCTGACACATGCTGGATGCCTGGCCAGTCATCTCCCAGCCGCCGGACC
AAGAGCAGCGCCCTCAAACTCTCCACCTTCGTGCCTTACCAGGACCGAGGAGGGCAGGAGCCTGCGGGCGCCGGCAGCCCCAGCCCCCCG
GAAGACCGGAACACCAAAACGGCCCCCGTGCGCCTCCTGCCCTCCTACAGTGCCTTCTCCCACAGTAGCCATGATTCCTGCAAGGACTCG
GCCACCTTGGAGGAAATCCCCCTGACCCAGACCTCGGACTTCCCACCCGCAGCCACACCGGCATCTGCCCAGACGGCCAAGCGCGAGATC
TACCTGTGAGCCCCCTACTGGCCGGCCGGCCCCCCTCCCCCAGCCGCCGGCCAGCTCCCAAATGGCCCATTCCAGGGCCTCACTCTCCAC
CCCTTCAGCGTGGACTTCCTGGCCAGGGCCCCAAGTGGGGGTATCACTGACCTCATGACCACGCTGGCCCTTCTCCCATGCAGGGTCCAG
GTCCTCTCCCCTCATTTCCATCTCCCAGCCCCCAGGGGCCCCTTCCCCTTTATGGGGCTTCCCCCATCTGATGCCCAAGAGGGCTCCTCT
GCAATGACTGGGCTCCTTCCCTTGACTTCCAGGGAGCACCCCCTCGATTTGGGCAGATGGTGGAGTCAAGGGTGGGCAGCGTACTTCTAA
CTCATTGTTTCCCTCATGGCCGACCAGGGCGGGGATAGCATGCCCAATTTTAGCCCTGAAGCAGGGCTGAACTGGGGAGCCCCTTTCCCT
GGGAGCTCCCAGAGGAAACTCTTGACCACCAGTGGCTCCCTGAAGGGCTTTTGTTACCAAAGGTGGGGTAGGGACGGGGGTGGGAGTGGA
GCGGAGGCCTTGTTTTCCCGTGCTGCTCCTGGACTGGCCCACCTGCCTGCCACATGCCCACGCCTAGTCCCATCTGGGCCCCCATTCCCT

>91739_91739_3_TMEM161A-PCDH1_TMEM161A_chr19_19249234_ENST00000587583_PCDH1_chr5_141248996_ENST00000503492_length(amino acids)=367AA_BP=
MILGPPRMEHLRHSPGPGGQRLLLPSMLLALLLLLAPSPGHATRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKT
GDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDR
DAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSY
EAELSENSPIGHSVIQLPHRRVTFSATSQAQELQDPSQHSYYDSGLEESETPSSKSSSGPRLGPLALPEDHYERTTPDGSIGEMEHPENE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for TMEM161A-PCDH1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM161A-PCDH1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TMEM161A-PCDH1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source