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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM161B-FAM81B (FusionGDB2 ID:91742)

Fusion Gene Summary for TMEM161B-FAM81B

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM161B-FAM81B
Fusion gene ID: 91742
HgeneTgene
Gene symbol

TMEM161B

FAM81B

Gene ID

153396

153643

Gene nametransmembrane protein 161Bfamily with sequence similarity 81 member B
SynonymsFLB3342|PRO1313-
Cytomap

5q14.3

5q15

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 161Bprotein FAM81B
Modification date2020031320200313
UniProtAcc.

Q96LP2

Ensembl transtripts involved in fusion geneENST00000296595, ENST00000512429, 
ENST00000514135, ENST00000506536, 
ENST00000509387, ENST00000511218, 
ENST00000515293, 		ENST00000506418, 
ENST00000283357, 
Fusion gene scores* DoF score4 X 5 X 4=803 X 4 X 3=36
# samples 44
** MAII scorelog2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TMEM161B [Title/Abstract] AND FAM81B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM161B(87524262)-FAM81B(94749651), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM161B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM81B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-97-8547-01ATMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
ChimerDB4LUADTCGA-97-8547-01ATMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+


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Fusion Gene ORF analysis for TMEM161B-FAM81B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296595ENST00000506418TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
5CDS-intronENST00000296595ENST00000506418TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
5CDS-intronENST00000512429ENST00000506418TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
5CDS-intronENST00000512429ENST00000506418TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
5CDS-intronENST00000514135ENST00000506418TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
5CDS-intronENST00000514135ENST00000506418TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
5UTR-3CDSENST00000506536ENST00000283357TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
5UTR-3CDSENST00000506536ENST00000283357TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
5UTR-3CDSENST00000509387ENST00000283357TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
5UTR-3CDSENST00000509387ENST00000283357TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
5UTR-intronENST00000506536ENST00000506418TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
5UTR-intronENST00000506536ENST00000506418TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
5UTR-intronENST00000509387ENST00000506418TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
5UTR-intronENST00000509387ENST00000506418TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
Frame-shiftENST00000296595ENST00000283357TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
Frame-shiftENST00000512429ENST00000283357TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
Frame-shiftENST00000514135ENST00000283357TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
In-frameENST00000296595ENST00000283357TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
In-frameENST00000512429ENST00000283357TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
In-frameENST00000514135ENST00000283357TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
intron-3CDSENST00000511218ENST00000283357TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
intron-3CDSENST00000511218ENST00000283357TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
intron-3CDSENST00000515293ENST00000283357TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
intron-3CDSENST00000515293ENST00000283357TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
intron-intronENST00000511218ENST00000506418TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
intron-intronENST00000511218ENST00000506418TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+
intron-intronENST00000515293ENST00000506418TMEM161Bchr5

87521586

-FAM81Bchr5

94749651

+
intron-intronENST00000515293ENST00000506418TMEM161Bchr5

87524262

-FAM81Bchr5

94749651

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000514135TMEM161Bchr587524262-ENST00000283357FAM81Bchr594749651+15192981071363418
ENST00000296595TMEM161Bchr587524262-ENST00000283357FAM81Bchr594749651+15373161251381418
ENST00000512429TMEM161Bchr587524262-ENST00000283357FAM81Bchr594749651+16504291931494433

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000514135ENST00000283357TMEM161Bchr587524262-FAM81Bchr594749651+0.0030406840.9969593
ENST00000296595ENST00000283357TMEM161Bchr587524262-FAM81Bchr594749651+0.0031877960.99681216
ENST00000512429ENST00000283357TMEM161Bchr587524262-FAM81Bchr594749651+0.0019164670.9980836

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Fusion Genomic Features for TMEM161B-FAM81B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMEM161Bchr587524261-FAM81Bchr594749650+2.48E-070.99999976
TMEM161Bchr587521585-FAM81Bchr594749650+1.01E-070.9999999
TMEM161Bchr587524261-FAM81Bchr594749650+2.48E-070.99999976
TMEM161Bchr587521585-FAM81Bchr594749650+1.01E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMEM161B-FAM81B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:87524262/chr5:94749651)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM81B

Q96LP2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM81Bchr5:87524262chr5:94749651ENST00000283357210164_19297453.0Coiled coilOntology_term=ECO:0000255
TgeneFAM81Bchr5:87524262chr5:94749651ENST00000283357210329_45297453.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM161Bchr5:87524262chr5:94749651ENST00000296595-312107_12763488.0TransmembraneHelical
HgeneTMEM161Bchr5:87524262chr5:94749651ENST00000296595-312136_15663488.0TransmembraneHelical
HgeneTMEM161Bchr5:87524262chr5:94749651ENST00000296595-312169_18963488.0TransmembraneHelical
HgeneTMEM161Bchr5:87524262chr5:94749651ENST00000296595-312228_24863488.0TransmembraneHelical
HgeneTMEM161Bchr5:87524262chr5:94749651ENST00000296595-312265_28563488.0TransmembraneHelical
HgeneTMEM161Bchr5:87524262chr5:94749651ENST00000296595-312305_32563488.0TransmembraneHelical
HgeneTMEM161Bchr5:87524262chr5:94749651ENST00000296595-312367_38763488.0TransmembraneHelical
HgeneTMEM161Bchr5:87524262chr5:94749651ENST00000296595-312459_47963488.0TransmembraneHelical


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Fusion Gene Sequence for TMEM161B-FAM81B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91742_91742_1_TMEM161B-FAM81B_TMEM161B_chr5_87524262_ENST00000296595_FAM81B_chr5_94749651_ENST00000283357_length(transcript)=1537nt_BP=316nt
GGCAGAGCCGGAAGACCCTCTCTTTCGCTGTTTGAGAGTCTCTCGGCTCAAGGACCGGGAGGTAAGAGGTTTGGGACTGCCCCGGCAACT
CCAGGGTGTCTGGTCCACGACCTATCCTAGGCGCCATGGGTGTGATAGGTATACAGCTGGTTGTTACCATGGTGATGGCCAGTGTCATGC
AGAAGATTATACCTCACTATTCTCTTGCTCGATGGCTACTCTGTAATGGCAGTTTGAGGTGGTATCAACATCCTACAGAAGAAGAATTAA
GAATTCTTGCAGGGAAACAACAAAAAGGGAAAACCAAAAAAGATAGGAGTCATGCTTTTCTCCCCATCATTCCAAACACCCAGAGAGGTC
AGCTAGAAGACAGACTGAACAACCAGGCGCGTACCATAGCTTTCCTTCTTGAACAAGCCTTCCGCATCAAGGAGGACATCTCTGCTTGCC
TGCAGGGGACCCATGGCTTTCGAAAAGAGGAATCGCTCGCCAGGAAGTTACTGGAAAGCCACATCCAGACCATCACCAGCATCGTCAAAA
AACTCAGCCAAAATATTGAGATTTTAGAAGACCAAATAAGAGCTCGAGATCAGGCGGCCACAGGAACTAACTTTGCAGTACACGAGATAA
ACATCAAACACCTACAAGGAGTTGGAGATCTTCGAGGAAGAGTAGCCAGATGTGATTCAAGCATTGTGAAGCTTTCTGGAGACATTCACT
TATTCAGGCAAGAGCACCGGCAAATTGAGAAAGCCATTCAAGAATTCGTGCCCGCCCTGGAAACTCTTTCCAAGAACTTGGACATGAAGG
TGATGCAGCTCTTAGGAAAGATAGAAACTGCCAGTCCTGAGCAAACCTCGAATTTAAAGATGGTCCAGGGGGATTATCGCCACGAAATGA
ACCTTTTGGAATTCAAATTTCATTCACTTTCAAGTAATCTGTACGAAGAAGTTGAGAATAATAAAAAATGGACAGAAAACCAATTTCTCA
AATATAGAAAAGACCACCTGGGCCATATAAATGAATGTCTGAAGGTCCTACAGGAGAAACTGGAAAAGTCTGAAAATAAAATGGAAGAAA
AACTGCTGCAGCTTTCAAGCAAAGTAGAGAATTTCATTAACACACAGAAACAGGAAACACAACTAAGTAAAGTAAAGCATATGGAAAATA
AATTGTCCAAAAAGATGGAACAAATGGAAAAGCAGATCTGGGGTGAATTAGAGACAATGCAGAATGAATATCAATCAGGATTTAAATCAA
TTCATGACTCTCTCAGCTCCCTCCAACAAATACAGAAAACAAAGATGGATTTAGAGAAATATAAAGTACAGAAAGACCTAAAGAAATTAC
AGCGCAAGATAGTGGAACTCCAGGAAGTATAAACCTTTTCAGTCATCTTCTTTTTCATCAGCCAATGGAGTGATTTGTTGGAAAAAGTTC
TGAAGAAGAAAGTTACTATCTCTGGGATGTTTACTGCTTCTAATGTCTCCTTTTAAGGAGACGAATGTACCAGAAAAATAATAAAGCAAA

>91742_91742_1_TMEM161B-FAM81B_TMEM161B_chr5_87524262_ENST00000296595_FAM81B_chr5_94749651_ENST00000283357_length(amino acids)=418AA_BP=63
MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKTKKDRSHAFLPIIPNTQRGQLEDRLNNQART
IAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLR
GRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASPEQTSNLKMVQGDYRHEMNLLEFKFHSLSS
NLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQ

--------------------------------------------------------------
>91742_91742_2_TMEM161B-FAM81B_TMEM161B_chr5_87524262_ENST00000512429_FAM81B_chr5_94749651_ENST00000283357_length(transcript)=1650nt_BP=429nt
CTCTTTCGCTGTTTGAGAGTCTCTCGGCTCAAGGACCGGGAGGTAAGAGGTTTGGGACTGCCCCGGCAACTCCAGGGTGTCTGGTCCACG
ACCTATCCTAGGCGCCATGGTTGCAAAGAAGAATGTAATCTTGTAGAGTACCTTGCCTTCCCTTCCATACATTCAGCAGACATAGTTCCT
TTAAGGGATTTTACTGCTAGGAGAATTTCATAGGTCATATTCCCATGTTACTGCTTCACAGGGTGTGATAGGTATACAGCTGGTTGTTAC
CATGGTGATGGCCAGTGTCATGCAGAAGATTATACCTCACTATTCTCTTGCTCGATGGCTACTCTGTAATGGCAGTTTGAGGTGGTATCA
ACATCCTACAGAAGAAGAATTAAGAATTCTTGCAGGGAAACAACAAAAAGGGAAAACCAAAAAAGATAGGAGTCATGCTTTTCTCCCCAT
CATTCCAAACACCCAGAGAGGTCAGCTAGAAGACAGACTGAACAACCAGGCGCGTACCATAGCTTTCCTTCTTGAACAAGCCTTCCGCAT
CAAGGAGGACATCTCTGCTTGCCTGCAGGGGACCCATGGCTTTCGAAAAGAGGAATCGCTCGCCAGGAAGTTACTGGAAAGCCACATCCA
GACCATCACCAGCATCGTCAAAAAACTCAGCCAAAATATTGAGATTTTAGAAGACCAAATAAGAGCTCGAGATCAGGCGGCCACAGGAAC
TAACTTTGCAGTACACGAGATAAACATCAAACACCTACAAGGAGTTGGAGATCTTCGAGGAAGAGTAGCCAGATGTGATTCAAGCATTGT
GAAGCTTTCTGGAGACATTCACTTATTCAGGCAAGAGCACCGGCAAATTGAGAAAGCCATTCAAGAATTCGTGCCCGCCCTGGAAACTCT
TTCCAAGAACTTGGACATGAAGGTGATGCAGCTCTTAGGAAAGATAGAAACTGCCAGTCCTGAGCAAACCTCGAATTTAAAGATGGTCCA
GGGGGATTATCGCCACGAAATGAACCTTTTGGAATTCAAATTTCATTCACTTTCAAGTAATCTGTACGAAGAAGTTGAGAATAATAAAAA
ATGGACAGAAAACCAATTTCTCAAATATAGAAAAGACCACCTGGGCCATATAAATGAATGTCTGAAGGTCCTACAGGAGAAACTGGAAAA
GTCTGAAAATAAAATGGAAGAAAAACTGCTGCAGCTTTCAAGCAAAGTAGAGAATTTCATTAACACACAGAAACAGGAAACACAACTAAG
TAAAGTAAAGCATATGGAAAATAAATTGTCCAAAAAGATGGAACAAATGGAAAAGCAGATCTGGGGTGAATTAGAGACAATGCAGAATGA
ATATCAATCAGGATTTAAATCAATTCATGACTCTCTCAGCTCCCTCCAACAAATACAGAAAACAAAGATGGATTTAGAGAAATATAAAGT
ACAGAAAGACCTAAAGAAATTACAGCGCAAGATAGTGGAACTCCAGGAAGTATAAACCTTTTCAGTCATCTTCTTTTTCATCAGCCAATG
GAGTGATTTGTTGGAAAAAGTTCTGAAGAAGAAAGTTACTATCTCTGGGATGTTTACTGCTTCTAATGTCTCCTTTTAAGGAGACGAATG

>91742_91742_2_TMEM161B-FAM81B_TMEM161B_chr5_87524262_ENST00000512429_FAM81B_chr5_94749651_ENST00000283357_length(amino acids)=433AA_BP=78
MLGEFHRSYSHVTASQGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKTKKDRSHAFLPIIPNT
QRGQLEDRLNNQARTIAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAV
HEINIKHLQGVGDLRGRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASPEQTSNLKMVQGDYR
HEMNLLEFKFHSLSSNLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKH

--------------------------------------------------------------
>91742_91742_3_TMEM161B-FAM81B_TMEM161B_chr5_87524262_ENST00000514135_FAM81B_chr5_94749651_ENST00000283357_length(transcript)=1519nt_BP=298nt
TCTCTTTCGCTGTTTGAGAGTCTCTCGGCTCAAGGACCGGGAGGTAAGAGGTTTGGGACTGCCCCGGCAACTCCAGGGTGTCTGGTCCAC
GACCTATCCTAGGCGCCATGGGTGTGATAGGTATACAGCTGGTTGTTACCATGGTGATGGCCAGTGTCATGCAGAAGATTATACCTCACT
ATTCTCTTGCTCGATGGCTACTCTGTAATGGCAGTTTGAGGTGGTATCAACATCCTACAGAAGAAGAATTAAGAATTCTTGCAGGGAAAC
AACAAAAAGGGAAAACCAAAAAAGATAGGAGTCATGCTTTTCTCCCCATCATTCCAAACACCCAGAGAGGTCAGCTAGAAGACAGACTGA
ACAACCAGGCGCGTACCATAGCTTTCCTTCTTGAACAAGCCTTCCGCATCAAGGAGGACATCTCTGCTTGCCTGCAGGGGACCCATGGCT
TTCGAAAAGAGGAATCGCTCGCCAGGAAGTTACTGGAAAGCCACATCCAGACCATCACCAGCATCGTCAAAAAACTCAGCCAAAATATTG
AGATTTTAGAAGACCAAATAAGAGCTCGAGATCAGGCGGCCACAGGAACTAACTTTGCAGTACACGAGATAAACATCAAACACCTACAAG
GAGTTGGAGATCTTCGAGGAAGAGTAGCCAGATGTGATTCAAGCATTGTGAAGCTTTCTGGAGACATTCACTTATTCAGGCAAGAGCACC
GGCAAATTGAGAAAGCCATTCAAGAATTCGTGCCCGCCCTGGAAACTCTTTCCAAGAACTTGGACATGAAGGTGATGCAGCTCTTAGGAA
AGATAGAAACTGCCAGTCCTGAGCAAACCTCGAATTTAAAGATGGTCCAGGGGGATTATCGCCACGAAATGAACCTTTTGGAATTCAAAT
TTCATTCACTTTCAAGTAATCTGTACGAAGAAGTTGAGAATAATAAAAAATGGACAGAAAACCAATTTCTCAAATATAGAAAAGACCACC
TGGGCCATATAAATGAATGTCTGAAGGTCCTACAGGAGAAACTGGAAAAGTCTGAAAATAAAATGGAAGAAAAACTGCTGCAGCTTTCAA
GCAAAGTAGAGAATTTCATTAACACACAGAAACAGGAAACACAACTAAGTAAAGTAAAGCATATGGAAAATAAATTGTCCAAAAAGATGG
AACAAATGGAAAAGCAGATCTGGGGTGAATTAGAGACAATGCAGAATGAATATCAATCAGGATTTAAATCAATTCATGACTCTCTCAGCT
CCCTCCAACAAATACAGAAAACAAAGATGGATTTAGAGAAATATAAAGTACAGAAAGACCTAAAGAAATTACAGCGCAAGATAGTGGAAC
TCCAGGAAGTATAAACCTTTTCAGTCATCTTCTTTTTCATCAGCCAATGGAGTGATTTGTTGGAAAAAGTTCTGAAGAAGAAAGTTACTA

>91742_91742_3_TMEM161B-FAM81B_TMEM161B_chr5_87524262_ENST00000514135_FAM81B_chr5_94749651_ENST00000283357_length(amino acids)=418AA_BP=63
MGVIGIQLVVTMVMASVMQKIIPHYSLARWLLCNGSLRWYQHPTEEELRILAGKQQKGKTKKDRSHAFLPIIPNTQRGQLEDRLNNQART
IAFLLEQAFRIKEDISACLQGTHGFRKEESLARKLLESHIQTITSIVKKLSQNIEILEDQIRARDQAATGTNFAVHEINIKHLQGVGDLR
GRVARCDSSIVKLSGDIHLFRQEHRQIEKAIQEFVPALETLSKNLDMKVMQLLGKIETASPEQTSNLKMVQGDYRHEMNLLEFKFHSLSS
NLYEEVENNKKWTENQFLKYRKDHLGHINECLKVLQEKLEKSENKMEEKLLQLSSKVENFINTQKQETQLSKVKHMENKLSKKMEQMEKQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMEM161B-FAM81B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM161B-FAM81B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM161B-FAM81B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource