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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM165-KIF5B (FusionGDB2 ID:91758)

Fusion Gene Summary for TMEM165-KIF5B

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM165-KIF5B
Fusion gene ID: 91758
HgeneTgene
Gene symbol

TMEM165

KIF5B

Gene ID

55858

3799

Gene nametransmembrane protein 165kinesin family member 5B
SynonymsCDG2K|FT27|GDT1|TMPT27|TPARLHEL-S-61|KINH|KNS|KNS1|UKHC
Cytomap

4q12

10p11.22

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 165TPA regulated locustransmembrane protein PT27transmembrane protein TPARLkinesin-1 heavy chainconventional kinesin heavy chainepididymis secretory protein Li 61kinesin 1 (110-120kD)kinesin heavy chainubiquitous kinesin heavy chain
Modification date2020031320200313
UniProtAcc.

P33176

Ensembl transtripts involved in fusion geneENST00000381334, ENST00000506198, 
ENST00000542052, ENST00000514904, 
ENST00000493889, ENST00000302418, 
Fusion gene scores* DoF score7 X 4 X 6=16811 X 12 X 5=660
# samples 912
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM165 [Title/Abstract] AND KIF5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM165(56262563)-KIF5B(32311964), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEM165

GO:0032472

Golgi calcium ion transport

23569283

TgeneKIF5B

GO:0042391

regulation of membrane potential

19675065

TgeneKIF5B

GO:0043268

positive regulation of potassium ion transport

19675065

TgeneKIF5B

GO:0047496

vesicle transport along microtubule

28426968

TgeneKIF5B

GO:1903078

positive regulation of protein localization to plasma membrane

19675065


check buttonFusion gene breakpoints across TMEM165 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIF5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IN-8462-11ATMEM165chr4

56262563

+KIF5Bchr10

32311964

-


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Fusion Gene ORF analysis for TMEM165-KIF5B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000381334ENST00000493889TMEM165chr4

56262563

+KIF5Bchr10

32311964

-
5CDS-intronENST00000506198ENST00000493889TMEM165chr4

56262563

+KIF5Bchr10

32311964

-
5UTR-3CDSENST00000542052ENST00000302418TMEM165chr4

56262563

+KIF5Bchr10

32311964

-
5UTR-intronENST00000542052ENST00000493889TMEM165chr4

56262563

+KIF5Bchr10

32311964

-
In-frameENST00000381334ENST00000302418TMEM165chr4

56262563

+KIF5Bchr10

32311964

-
In-frameENST00000506198ENST00000302418TMEM165chr4

56262563

+KIF5Bchr10

32311964

-
intron-3CDSENST00000514904ENST00000302418TMEM165chr4

56262563

+KIF5Bchr10

32311964

-
intron-intronENST00000514904ENST00000493889TMEM165chr4

56262563

+KIF5Bchr10

32311964

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000506198TMEM165chr456262563+ENST00000302418KIF5Bchr1032311964-41344401581606482
ENST00000381334TMEM165chr456262563+ENST00000302418KIF5Bchr1032311964-41344401581606482

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000506198ENST00000302418TMEM165chr456262563+KIF5Bchr1032311964-0.0002130420.9997869
ENST00000381334ENST00000302418TMEM165chr456262563+KIF5Bchr1032311964-0.0002130420.9997869

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Fusion Genomic Features for TMEM165-KIF5B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM165-KIF5B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:56262563/chr10:32311964)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KIF5B

P33176

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIF5Bchr4:56262563chr10:32311964ENST000003024181426915_9635751626.0RegionNote=Globular

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16184_21169325.0Coiled coilOntology_term=ECO:0000255
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16111_12669325.0Topological domainCytoplasmic
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16148_15169325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16173_22869325.0Topological domainCytoplasmic
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16250_26769325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16289_29969325.0Topological domainCytoplasmic
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16321_32469325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+1634_8969325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16127_14769325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16152_17269325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16229_24969325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16268_28869325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+16300_32069325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr10:32311964ENST00000381334+1690_11069325.0TransmembraneHelical
TgeneKIF5Bchr4:56262563chr10:32311964ENST000003024181426329_9145751626.0Coiled coil.
TgeneKIF5Bchr4:56262563chr10:32311964ENST0000030241814268_3255751626.0DomainKinesin motor
TgeneKIF5Bchr4:56262563chr10:32311964ENST00000302418142685_925751626.0Nucleotide bindingNote=ATP


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Fusion Gene Sequence for TMEM165-KIF5B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91758_91758_1_TMEM165-KIF5B_TMEM165_chr4_56262563_ENST00000381334_KIF5B_chr10_32311964_ENST00000302418_length(transcript)=4134nt_BP=440nt
GACTCCAGTTTAGCCGCCGCCGGAGAGGACGGGCGCCGAGCCGGGGCTGCGGACTTCGGCCTGCCCCTCACCTCACTCCCGCTGCTTGCA
CCTCCCGGATGGTGCTGACTGCTCCCTAAGCGGCGGCGGCGGCGAGTCGTGAGGACGCGCCGCGGAGGCTGTTCGGGGTCGAGGCTTCCC
GTCGCCGGCACTTCCTCTTGCGGCGCCCGTGCGCGGCCGGCCCGGCAGGCGGGATGGCGGCCGCGGCTCCAGGGAACGGCCGCGCATCGG
CGCCCCGGCTGCTTCTGCTCTTTCTGGTTCCGCTGCTGTGGGCCCCGGCTGCGGTCCGGGCCGGCCCAGATGAAGACCTTAGCCACCGGA
ACAAAGAACCGCCGGCGCCGGCCCAGCAGCTGCAGCCGCAGCCTGTGGCTGTGCAGGGCCCCGAGCCGGCCCGGGTCGAGCAGCCTGAGG
GAACTGGCATGATAGATGAAGAGTTCACTGTTGCAAGACTCTACATTAGCAAAATGAAGTCAGAAGTAAAAACCATGGTGAAACGTTGCA
AGCAGTTAGAAAGCACACAAACTGAGAGCAACAAAAAAATGGAAGAAAATGAAAAGGAGTTAGCAGCATGTCAGCTTCGTATCTCTCAAC
ATGAAGCCAAAATCAAGTCATTGACTGAATACCTTCAAAATGTGGAACAAAAGAAAAGACAGTTGGAGGAATCTGTCGATGCCCTCAGTG
AAGAACTAGTCCAGCTTCGAGCACAAGAGAAAGTCCATGAAATGGAAAAGGAGCACTTAAATAAGGTTCAGACTGCAAATGAAGTTAAGC
AAGCTGTTGAACAGCAGATCCAGAGCCATAGAGAAACTCATCAAAAACAGATCAGTAGTTTGAGAGATGAAGTAGAAGCAAAAGCAAAAC
TTATTACTGATCTTCAAGACCAAAACCAGAAAATGATGTTAGAGCAGGAACGTCTAAGAGTAGAACATGAGAAGTTGAAAGCCACAGATC
AGGAAAAGAGCAGAAAACTACATGAACTTACGGTTATGCAAGATAGACGAGAACAAGCAAGACAAGACTTGAAGGGTTTGGAAGAGACAG
TGGCAAAAGAACTTCAGACTTTACACAACCTGCGCAAACTCTTTGTTCAGGACCTGGCTACAAGAGTTAAAAAGAGTGCTGAGATTGATT
CTGATGACACCGGAGGCAGCGCTGCTCAGAAGCAAAAAATCTCCTTTCTTGAAAATAATCTTGAACAGCTCACTAAAGTGCACAAACAGT
TGGTACGTGATAATGCAGATCTCCGCTGTGAACTTCCTAAGTTGGAAAAGCGACTTCGAGCTACAGCTGAGAGAGTGAAAGCTTTGGAAT
CAGCACTGAAAGAAGCTAAAGAAAATGCATCTCGTGATCGCAAACGCTATCAGCAAGAAGTAGATCGCATAAAGGAAGCAGTCAGGTCAA
AGAATATGGCCAGAAGAGGGCATTCTGCACAGATTGCTAAACCTATTCGTCCCGGGCAACATCCAGCAGCTTCTCCAACTCACCCAAGTG
CAATTCGTGGAGGAGGTGCATTTGTTCAGAACAGCCAGCCAGTGGCAGTGCGAGGTGGAGGAGGCAAACAAGTGTAATCGTTTATACATA
CCCACAGGTGTTAAAAAGTAATCGAAGTACGAAGAGGACATGGTATCAAGCAGTCATTCAATGACTATAACCTCTACTCCCTTGGGATTG
TAGAATTATAACTTTTAAAAAAAATGTATAAATTATACCTGGCCTGTACAGCTGTTTCCTACCTACTCTTCTTGTAAACTCTGCTGCTTC
CCAACACAACTAGAGTGCAATTTTGGCATCTTAGGAGGGAAAAAGGACAGTTTACAACTGTGGCCCTATTTATTACACAGTTTGTCTATC
GTGTCTTAAATTTAGTCTTTACTGTGCCAAGCTAACTGTACCTTATAGGACTGTACTTTTTGTATTTTTTGTGTATGTTTATTTTTTAAT
CTCAGTTTAAATTACCTAGCTGCTACTGCTTCTTGTTTTTCTTTTCCTATTAAAACGTCTTCCTTTTTTTTTCTTAAGAGAAAATGGAAC
ATTTAGGTTAAATGTCTTTAAATTTTACCACTTAACAACACTACATGCCCATAAAATATATCCAGTCAGTACTGTATTTTAAAATCCCTT
GAAATGATGATATCAGGGTTAAAATTACTTGTATTGTTTCTGAAGTTTGCTCCTGAAAACTACTGTTTGAGCACTGAAACGTTACAAATG
CCTAATAGGCATTTGAGACTGAGCAAGGCTACTTGTTATCTCATGAAATGCCTGTTGCCGAGTTATTTTGAATAGAAATATTTTAAAGTA
TCAAAAGCAGATCTTAGTTTAAGGGAGTTTGGAAAAGGAATTATATTTCTCTTTTTCCTGATTCTGTACTCAACAAGTCTTGATGGAATT
AAAATACTCTGCTTTATTCTGGTGAGCCTGCTAGCTAATATAAGTATTGGACAGGTAATAATTTGTCATCTTTAATATTAGTAAAATGAA
TTAAGATATTATAGGATTAAACATAATTTTATACGGTTAGTACTTTATTGGCCGACCTAAATTTATAGCGTGTGGAAATTGAGAAAAATG
AAGAAACAGGACAGATATATGATGAATTAAAAATATATATAGGTCAATTTTGGTCTGAAATCCCTGAGGTGTTTTTAACCTGCTACACTA
ATTTGTACACTAATTTATTTCTTTAGTCTAGAAATAGTAAATTGTTTGCAAGTCACTAATAATCATTAGATAAATTATTTTCTTGGCCAT
AGCCGATAATTTTGTAATCAGTACTAAGTGTATACGTATTTTTGCCACTTTTTCCTCAGATGATTAAAGTAAGTCAACAGCTTATTTTAG
GAAACTGTAAAAGTAATAGGGAAAGAGATTTCACTATTTGCTTCATCAGTGGTAGGGGGGCGGTGACTGCAACTGTGTTAGCAGAAATTC
ACAGAGAATGGGGATTTAAGGTTAGCAGAGAAACTTGGAAAGTTCTGTGTTAGGATCTTGCTGGCAGAATTAACTTTTTGCAAAAGTTTT
ATACACAGATATTTGTATTAAATTTGGAGCCATAGTCAGAAGACTCAGATCATAATTGGCTTATTTTTCTATTTCCGTAACTATTGTAAT
TTCCACTTTTGTAATAATTTTGATTTAAAATATAAATTTATTTATTTATTTTTTTAATAGTCAAAAATCTTTGCTGTTGTAGTCTGCAAC
CTCTAAAATGATTGTGTTGCTTTTAGGATTGATCAGAAGAAACACTCCAAAAATTGAGATGAAATGTTGGTGCAGCCAGTTATAAGTAAT
ATAGTTAACAAGCAAAAAAAGTGCTGCCACCTTTTATGATGATTTTCTAAATGGAGAAACATTTGGCTGCATCCACATAGACCTTTATGT
TTTGTTTTCAGTTGAAAACTTGCCTCCTTTGGCAACATTCGTAAATGAAGCAGAATTTTTTTTTCTCTTTTTTCCAAATATGTTAGTTTT
GTTCTTGTAAGATGTATCATGGGTATTGGTGCTGTGTAATGAACAACGAATTTTAATTAGCATGTGGTTCAGAATATACAATGTTAGGTT
TTTAAAAAGTATCTTGATGGTTCTTTTCTATTTATAATTTCAGACTTTCATAAAGTGTACCAAGAATTTCATAAATTTGTTTTCAGTGAA
CTGCTTTTTGCTATGGTAGGTCATTAAACACAGCACTTACTCTTAAAAATGAAAATTTCTGATCATCTAGGATATTGACACATTTCAATT
TGCAGTGTCTTTTTGACTGGATATATTAACGTTCCTCTGAATGGCATTGATAGATGGTTCAGAAGAGAAACTCAATGAAATAAAGAGAAT
ATTTATTCATGGCGATTAATTAAATTATTTGCCTAACTTAAGAAAACTACTGTGCGTAACTCTCAGTTTGTGCTTAACTCCATTTGACAT
GAGGTGACAGAAGAGAGTCTGAGTCTACCTGTGGAATATGTTGGTTTATTTTCAGTGCTTGAAGATACATTCACAAATACTTGGTTTGGG

>91758_91758_1_TMEM165-KIF5B_TMEM165_chr4_56262563_ENST00000381334_KIF5B_chr10_32311964_ENST00000302418_length(amino acids)=482AA_BP=94
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLE
ESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEH
EKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQ
LTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPA

--------------------------------------------------------------
>91758_91758_2_TMEM165-KIF5B_TMEM165_chr4_56262563_ENST00000506198_KIF5B_chr10_32311964_ENST00000302418_length(transcript)=4134nt_BP=440nt
GACTCCAGTTTAGCCGCCGCCGGAGAGGACGGGCGCCGAGCCGGGGCTGCGGACTTCGGCCTGCCCCTCACCTCACTCCCGCTGCTTGCA
CCTCCCGGATGGTGCTGACTGCTCCCTAAGCGGCGGCGGCGGCGAGTCGTGAGGACGCGCCGCGGAGGCTGTTCGGGGTCGAGGCTTCCC
GTCGCCGGCACTTCCTCTTGCGGCGCCCGTGCGCGGCCGGCCCGGCAGGCGGGATGGCGGCCGCGGCTCCAGGGAACGGCCGCGCATCGG
CGCCCCGGCTGCTTCTGCTCTTTCTGGTTCCGCTGCTGTGGGCCCCGGCTGCGGTCCGGGCCGGCCCAGATGAAGACCTTAGCCACCGGA
ACAAAGAACCGCCGGCGCCGGCCCAGCAGCTGCAGCCGCAGCCTGTGGCTGTGCAGGGCCCCGAGCCGGCCCGGGTCGAGCAGCCTGAGG
GAACTGGCATGATAGATGAAGAGTTCACTGTTGCAAGACTCTACATTAGCAAAATGAAGTCAGAAGTAAAAACCATGGTGAAACGTTGCA
AGCAGTTAGAAAGCACACAAACTGAGAGCAACAAAAAAATGGAAGAAAATGAAAAGGAGTTAGCAGCATGTCAGCTTCGTATCTCTCAAC
ATGAAGCCAAAATCAAGTCATTGACTGAATACCTTCAAAATGTGGAACAAAAGAAAAGACAGTTGGAGGAATCTGTCGATGCCCTCAGTG
AAGAACTAGTCCAGCTTCGAGCACAAGAGAAAGTCCATGAAATGGAAAAGGAGCACTTAAATAAGGTTCAGACTGCAAATGAAGTTAAGC
AAGCTGTTGAACAGCAGATCCAGAGCCATAGAGAAACTCATCAAAAACAGATCAGTAGTTTGAGAGATGAAGTAGAAGCAAAAGCAAAAC
TTATTACTGATCTTCAAGACCAAAACCAGAAAATGATGTTAGAGCAGGAACGTCTAAGAGTAGAACATGAGAAGTTGAAAGCCACAGATC
AGGAAAAGAGCAGAAAACTACATGAACTTACGGTTATGCAAGATAGACGAGAACAAGCAAGACAAGACTTGAAGGGTTTGGAAGAGACAG
TGGCAAAAGAACTTCAGACTTTACACAACCTGCGCAAACTCTTTGTTCAGGACCTGGCTACAAGAGTTAAAAAGAGTGCTGAGATTGATT
CTGATGACACCGGAGGCAGCGCTGCTCAGAAGCAAAAAATCTCCTTTCTTGAAAATAATCTTGAACAGCTCACTAAAGTGCACAAACAGT
TGGTACGTGATAATGCAGATCTCCGCTGTGAACTTCCTAAGTTGGAAAAGCGACTTCGAGCTACAGCTGAGAGAGTGAAAGCTTTGGAAT
CAGCACTGAAAGAAGCTAAAGAAAATGCATCTCGTGATCGCAAACGCTATCAGCAAGAAGTAGATCGCATAAAGGAAGCAGTCAGGTCAA
AGAATATGGCCAGAAGAGGGCATTCTGCACAGATTGCTAAACCTATTCGTCCCGGGCAACATCCAGCAGCTTCTCCAACTCACCCAAGTG
CAATTCGTGGAGGAGGTGCATTTGTTCAGAACAGCCAGCCAGTGGCAGTGCGAGGTGGAGGAGGCAAACAAGTGTAATCGTTTATACATA
CCCACAGGTGTTAAAAAGTAATCGAAGTACGAAGAGGACATGGTATCAAGCAGTCATTCAATGACTATAACCTCTACTCCCTTGGGATTG
TAGAATTATAACTTTTAAAAAAAATGTATAAATTATACCTGGCCTGTACAGCTGTTTCCTACCTACTCTTCTTGTAAACTCTGCTGCTTC
CCAACACAACTAGAGTGCAATTTTGGCATCTTAGGAGGGAAAAAGGACAGTTTACAACTGTGGCCCTATTTATTACACAGTTTGTCTATC
GTGTCTTAAATTTAGTCTTTACTGTGCCAAGCTAACTGTACCTTATAGGACTGTACTTTTTGTATTTTTTGTGTATGTTTATTTTTTAAT
CTCAGTTTAAATTACCTAGCTGCTACTGCTTCTTGTTTTTCTTTTCCTATTAAAACGTCTTCCTTTTTTTTTCTTAAGAGAAAATGGAAC
ATTTAGGTTAAATGTCTTTAAATTTTACCACTTAACAACACTACATGCCCATAAAATATATCCAGTCAGTACTGTATTTTAAAATCCCTT
GAAATGATGATATCAGGGTTAAAATTACTTGTATTGTTTCTGAAGTTTGCTCCTGAAAACTACTGTTTGAGCACTGAAACGTTACAAATG
CCTAATAGGCATTTGAGACTGAGCAAGGCTACTTGTTATCTCATGAAATGCCTGTTGCCGAGTTATTTTGAATAGAAATATTTTAAAGTA
TCAAAAGCAGATCTTAGTTTAAGGGAGTTTGGAAAAGGAATTATATTTCTCTTTTTCCTGATTCTGTACTCAACAAGTCTTGATGGAATT
AAAATACTCTGCTTTATTCTGGTGAGCCTGCTAGCTAATATAAGTATTGGACAGGTAATAATTTGTCATCTTTAATATTAGTAAAATGAA
TTAAGATATTATAGGATTAAACATAATTTTATACGGTTAGTACTTTATTGGCCGACCTAAATTTATAGCGTGTGGAAATTGAGAAAAATG
AAGAAACAGGACAGATATATGATGAATTAAAAATATATATAGGTCAATTTTGGTCTGAAATCCCTGAGGTGTTTTTAACCTGCTACACTA
ATTTGTACACTAATTTATTTCTTTAGTCTAGAAATAGTAAATTGTTTGCAAGTCACTAATAATCATTAGATAAATTATTTTCTTGGCCAT
AGCCGATAATTTTGTAATCAGTACTAAGTGTATACGTATTTTTGCCACTTTTTCCTCAGATGATTAAAGTAAGTCAACAGCTTATTTTAG
GAAACTGTAAAAGTAATAGGGAAAGAGATTTCACTATTTGCTTCATCAGTGGTAGGGGGGCGGTGACTGCAACTGTGTTAGCAGAAATTC
ACAGAGAATGGGGATTTAAGGTTAGCAGAGAAACTTGGAAAGTTCTGTGTTAGGATCTTGCTGGCAGAATTAACTTTTTGCAAAAGTTTT
ATACACAGATATTTGTATTAAATTTGGAGCCATAGTCAGAAGACTCAGATCATAATTGGCTTATTTTTCTATTTCCGTAACTATTGTAAT
TTCCACTTTTGTAATAATTTTGATTTAAAATATAAATTTATTTATTTATTTTTTTAATAGTCAAAAATCTTTGCTGTTGTAGTCTGCAAC
CTCTAAAATGATTGTGTTGCTTTTAGGATTGATCAGAAGAAACACTCCAAAAATTGAGATGAAATGTTGGTGCAGCCAGTTATAAGTAAT
ATAGTTAACAAGCAAAAAAAGTGCTGCCACCTTTTATGATGATTTTCTAAATGGAGAAACATTTGGCTGCATCCACATAGACCTTTATGT
TTTGTTTTCAGTTGAAAACTTGCCTCCTTTGGCAACATTCGTAAATGAAGCAGAATTTTTTTTTCTCTTTTTTCCAAATATGTTAGTTTT
GTTCTTGTAAGATGTATCATGGGTATTGGTGCTGTGTAATGAACAACGAATTTTAATTAGCATGTGGTTCAGAATATACAATGTTAGGTT
TTTAAAAAGTATCTTGATGGTTCTTTTCTATTTATAATTTCAGACTTTCATAAAGTGTACCAAGAATTTCATAAATTTGTTTTCAGTGAA
CTGCTTTTTGCTATGGTAGGTCATTAAACACAGCACTTACTCTTAAAAATGAAAATTTCTGATCATCTAGGATATTGACACATTTCAATT
TGCAGTGTCTTTTTGACTGGATATATTAACGTTCCTCTGAATGGCATTGATAGATGGTTCAGAAGAGAAACTCAATGAAATAAAGAGAAT
ATTTATTCATGGCGATTAATTAAATTATTTGCCTAACTTAAGAAAACTACTGTGCGTAACTCTCAGTTTGTGCTTAACTCCATTTGACAT
GAGGTGACAGAAGAGAGTCTGAGTCTACCTGTGGAATATGTTGGTTTATTTTCAGTGCTTGAAGATACATTCACAAATACTTGGTTTGGG

>91758_91758_2_TMEM165-KIF5B_TMEM165_chr4_56262563_ENST00000506198_KIF5B_chr10_32311964_ENST00000302418_length(amino acids)=482AA_BP=94
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLE
ESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEH
EKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQ
LTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPA

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Fusion Gene PPI Analysis for TMEM165-KIF5B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM165-KIF5B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM165-KIF5B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource