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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM165-PDGFRA (FusionGDB2 ID:91759)

Fusion Gene Summary for TMEM165-PDGFRA

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM165-PDGFRA
Fusion gene ID: 91759
HgeneTgene
Gene symbol

TMEM165

PDGFRA

Gene ID

55858

5156

Gene nametransmembrane protein 165platelet derived growth factor receptor alpha
SynonymsCDG2K|FT27|GDT1|TMPT27|TPARLCD140A|PDGFR-2|PDGFR2
Cytomap

4q12

4q12

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 165TPA regulated locustransmembrane protein PT27transmembrane protein TPARLplatelet-derived growth factor receptor alphaCD140 antigen-like family member ACD140a antigenPDGF-R-alphaalpha-type platelet-derived growth factor receptorplatelet-derived growth factor receptor 2platelet-derived growth factor receptor, alpha polype
Modification date2020031320200329
UniProtAcc.

P16234

Ensembl transtripts involved in fusion geneENST00000381334, ENST00000506198, 
ENST00000542052, ENST00000514904, 
ENST00000508170, ENST00000257290, 
Fusion gene scores* DoF score7 X 4 X 6=16818 X 27 X 8=3888
# samples 917
** MAII scorelog2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/3888*10)=-4.51542156746808
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TMEM165 [Title/Abstract] AND PDGFRA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM165(56262563)-PDGFRA(55133456), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTMEM165

GO:0032472

Golgi calcium ion transport

23569283

TgenePDGFRA

GO:0008284

positive regulation of cell proliferation

10806482

TgenePDGFRA

GO:0010544

negative regulation of platelet activation

8188664

TgenePDGFRA

GO:0018108

peptidyl-tyrosine phosphorylation

1646396|2536956|8188664

TgenePDGFRA

GO:0030335

positive regulation of cell migration

17470632

TgenePDGFRA

GO:0034614

cellular response to reactive oxygen species

24190966

TgenePDGFRA

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

17470632

TgenePDGFRA

GO:0046777

protein autophosphorylation

1646396|2536956|8188664

TgenePDGFRA

GO:0048008

platelet-derived growth factor receptor signaling pathway

2536956|10806482

TgenePDGFRA

GO:0048146

positive regulation of fibroblast proliferation

10806482


check buttonFusion gene breakpoints across TMEM165 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDGFRA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-2559-01ATMEM165chr4

56262563

+PDGFRAchr4

55133456

+
ChimerDB4GBMTCGA-06-2559TMEM165chr4

56262563

+PDGFRAchr4

55133455

+
ChimerDB4LGGTCGA-CS-6665-01ATMEM165chr4

56262563

+PDGFRAchr4

55133456

+
ChimerDB4LGGTCGA-CS-6665TMEM165chr4

56262563

+PDGFRAchr4

55133456

+


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Fusion Gene ORF analysis for TMEM165-PDGFRA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000381334ENST00000508170TMEM165chr4

56262563

+PDGFRAchr4

55133456

+
5CDS-intronENST00000381334ENST00000508170TMEM165chr4

56262563

+PDGFRAchr4

55133455

+
5CDS-intronENST00000506198ENST00000508170TMEM165chr4

56262563

+PDGFRAchr4

55133456

+
5CDS-intronENST00000506198ENST00000508170TMEM165chr4

56262563

+PDGFRAchr4

55133455

+
5UTR-3CDSENST00000542052ENST00000257290TMEM165chr4

56262563

+PDGFRAchr4

55133456

+
5UTR-3CDSENST00000542052ENST00000257290TMEM165chr4

56262563

+PDGFRAchr4

55133455

+
5UTR-intronENST00000542052ENST00000508170TMEM165chr4

56262563

+PDGFRAchr4

55133456

+
5UTR-intronENST00000542052ENST00000508170TMEM165chr4

56262563

+PDGFRAchr4

55133455

+
In-frameENST00000381334ENST00000257290TMEM165chr4

56262563

+PDGFRAchr4

55133456

+
In-frameENST00000381334ENST00000257290TMEM165chr4

56262563

+PDGFRAchr4

55133455

+
In-frameENST00000506198ENST00000257290TMEM165chr4

56262563

+PDGFRAchr4

55133456

+
In-frameENST00000506198ENST00000257290TMEM165chr4

56262563

+PDGFRAchr4

55133455

+
intron-3CDSENST00000514904ENST00000257290TMEM165chr4

56262563

+PDGFRAchr4

55133456

+
intron-3CDSENST00000514904ENST00000257290TMEM165chr4

56262563

+PDGFRAchr4

55133455

+
intron-intronENST00000514904ENST00000508170TMEM165chr4

56262563

+PDGFRAchr4

55133456

+
intron-intronENST00000514904ENST00000508170TMEM165chr4

56262563

+PDGFRAchr4

55133455

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000506198TMEM165chr456262563+ENST00000257290PDGFRAchr455133456+59264401582950930
ENST00000381334TMEM165chr456262563+ENST00000257290PDGFRAchr455133456+59264401582950930
ENST00000506198TMEM165chr456262563+ENST00000257290PDGFRAchr455133455+59264401582950930
ENST00000381334TMEM165chr456262563+ENST00000257290PDGFRAchr455133455+59264401582950930

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000506198ENST00000257290TMEM165chr456262563+PDGFRAchr455133456+0.0002937360.9997062
ENST00000381334ENST00000257290TMEM165chr456262563+PDGFRAchr455133456+0.0002937360.9997062
ENST00000506198ENST00000257290TMEM165chr456262563+PDGFRAchr455133455+0.0002937360.9997062
ENST00000381334ENST00000257290TMEM165chr456262563+PDGFRAchr455133455+0.0002937360.9997062

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Fusion Genomic Features for TMEM165-PDGFRA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMEM165chr456262563+PDGFRAchr455133455+1.97E-121
TMEM165chr456262563+PDGFRAchr455133455+1.97E-121
TMEM165chr456262563+PDGFRAchr455133455+1.97E-121
TMEM165chr456262563+PDGFRAchr455133455+1.97E-121
TMEM165chr456262563+PDGFRAchr455133455+1.97E-121
TMEM165chr456262563+PDGFRAchr455133455+1.97E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMEM165-PDGFRA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:56262563/chr4:55133456)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PDGFRA

P16234

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:10734113, ECO:0000269|PubMed:10947961, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:12522257, ECO:0000269|PubMed:1646396, ECO:0000269|PubMed:17087943, ECO:0000269|PubMed:1709159, ECO:0000269|PubMed:17141222, ECO:0000269|PubMed:20972453, ECO:0000269|PubMed:21224473, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:2554309, ECO:0000269|PubMed:8188664, ECO:0000269|PubMed:8760137, ECO:0000269|PubMed:8943348}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDGFRAchr4:56262563chr4:55133455ENST000002572904231041_10872531090.0Compositional biasNote=Ser-rich
TgenePDGFRAchr4:56262563chr4:55133455ENST00000508170041041_10870219.0Compositional biasNote=Ser-rich
TgenePDGFRAchr4:56262563chr4:55133456ENST000002572904231041_10872531090.0Compositional biasNote=Ser-rich
TgenePDGFRAchr4:56262563chr4:55133456ENST00000508170041041_10870219.0Compositional biasNote=Ser-rich
TgenePDGFRAchr4:56262563chr4:55133455ENST00000257290423319_4102531090.0DomainNote=Ig-like C2-type 4
TgenePDGFRAchr4:56262563chr4:55133455ENST00000257290423414_5172531090.0DomainNote=Ig-like C2-type 5
TgenePDGFRAchr4:56262563chr4:55133455ENST00000257290423593_9542531090.0DomainProtein kinase
TgenePDGFRAchr4:56262563chr4:55133455ENST0000050817004117_2010219.0DomainNote=Ig-like C2-type 2
TgenePDGFRAchr4:56262563chr4:55133455ENST0000050817004202_3060219.0DomainNote=Ig-like C2-type 3
TgenePDGFRAchr4:56262563chr4:55133455ENST000005081700424_1130219.0DomainNote=Ig-like C2-type 1
TgenePDGFRAchr4:56262563chr4:55133455ENST0000050817004319_4100219.0DomainNote=Ig-like C2-type 4
TgenePDGFRAchr4:56262563chr4:55133455ENST0000050817004414_5170219.0DomainNote=Ig-like C2-type 5
TgenePDGFRAchr4:56262563chr4:55133455ENST0000050817004593_9540219.0DomainProtein kinase
TgenePDGFRAchr4:56262563chr4:55133456ENST00000257290423319_4102531090.0DomainNote=Ig-like C2-type 4
TgenePDGFRAchr4:56262563chr4:55133456ENST00000257290423414_5172531090.0DomainNote=Ig-like C2-type 5
TgenePDGFRAchr4:56262563chr4:55133456ENST00000257290423593_9542531090.0DomainProtein kinase
TgenePDGFRAchr4:56262563chr4:55133456ENST0000050817004117_2010219.0DomainNote=Ig-like C2-type 2
TgenePDGFRAchr4:56262563chr4:55133456ENST0000050817004202_3060219.0DomainNote=Ig-like C2-type 3
TgenePDGFRAchr4:56262563chr4:55133456ENST000005081700424_1130219.0DomainNote=Ig-like C2-type 1
TgenePDGFRAchr4:56262563chr4:55133456ENST0000050817004319_4100219.0DomainNote=Ig-like C2-type 4
TgenePDGFRAchr4:56262563chr4:55133456ENST0000050817004414_5170219.0DomainNote=Ig-like C2-type 5
TgenePDGFRAchr4:56262563chr4:55133456ENST0000050817004593_9540219.0DomainProtein kinase
TgenePDGFRAchr4:56262563chr4:55133455ENST00000257290423599_6072531090.0Nucleotide bindingATP
TgenePDGFRAchr4:56262563chr4:55133455ENST0000050817004599_6070219.0Nucleotide bindingATP
TgenePDGFRAchr4:56262563chr4:55133456ENST00000257290423599_6072531090.0Nucleotide bindingATP
TgenePDGFRAchr4:56262563chr4:55133456ENST0000050817004599_6070219.0Nucleotide bindingATP
TgenePDGFRAchr4:56262563chr4:55133455ENST00000257290423550_10892531090.0Topological domainCytoplasmic
TgenePDGFRAchr4:56262563chr4:55133455ENST000005081700424_5280219.0Topological domainExtracellular
TgenePDGFRAchr4:56262563chr4:55133455ENST0000050817004550_10890219.0Topological domainCytoplasmic
TgenePDGFRAchr4:56262563chr4:55133456ENST00000257290423550_10892531090.0Topological domainCytoplasmic
TgenePDGFRAchr4:56262563chr4:55133456ENST000005081700424_5280219.0Topological domainExtracellular
TgenePDGFRAchr4:56262563chr4:55133456ENST0000050817004550_10890219.0Topological domainCytoplasmic
TgenePDGFRAchr4:56262563chr4:55133455ENST00000257290423529_5492531090.0TransmembraneHelical
TgenePDGFRAchr4:56262563chr4:55133455ENST0000050817004529_5490219.0TransmembraneHelical
TgenePDGFRAchr4:56262563chr4:55133456ENST00000257290423529_5492531090.0TransmembraneHelical
TgenePDGFRAchr4:56262563chr4:55133456ENST0000050817004529_5490219.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16184_21169325.0Coiled coilOntology_term=ECO:0000255
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16184_21169325.0Coiled coilOntology_term=ECO:0000255
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16111_12669325.0Topological domainCytoplasmic
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16148_15169325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16173_22869325.0Topological domainCytoplasmic
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16250_26769325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16289_29969325.0Topological domainCytoplasmic
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16321_32469325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+1634_8969325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16111_12669325.0Topological domainCytoplasmic
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16148_15169325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16173_22869325.0Topological domainCytoplasmic
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16250_26769325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16289_29969325.0Topological domainCytoplasmic
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16321_32469325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+1634_8969325.0Topological domainLumenal
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16127_14769325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16152_17269325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16229_24969325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16268_28869325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+16300_32069325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133455ENST00000381334+1690_11069325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16127_14769325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16152_17269325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16229_24969325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16268_28869325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+16300_32069325.0TransmembraneHelical
HgeneTMEM165chr4:56262563chr4:55133456ENST00000381334+1690_11069325.0TransmembraneHelical
TgenePDGFRAchr4:56262563chr4:55133455ENST00000257290423117_2012531090.0DomainNote=Ig-like C2-type 2
TgenePDGFRAchr4:56262563chr4:55133455ENST00000257290423202_3062531090.0DomainNote=Ig-like C2-type 3
TgenePDGFRAchr4:56262563chr4:55133455ENST0000025729042324_1132531090.0DomainNote=Ig-like C2-type 1
TgenePDGFRAchr4:56262563chr4:55133456ENST00000257290423117_2012531090.0DomainNote=Ig-like C2-type 2
TgenePDGFRAchr4:56262563chr4:55133456ENST00000257290423202_3062531090.0DomainNote=Ig-like C2-type 3
TgenePDGFRAchr4:56262563chr4:55133456ENST0000025729042324_1132531090.0DomainNote=Ig-like C2-type 1
TgenePDGFRAchr4:56262563chr4:55133455ENST0000025729042324_5282531090.0Topological domainExtracellular
TgenePDGFRAchr4:56262563chr4:55133456ENST0000025729042324_5282531090.0Topological domainExtracellular


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Fusion Gene Sequence for TMEM165-PDGFRA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91759_91759_1_TMEM165-PDGFRA_TMEM165_chr4_56262563_ENST00000381334_PDGFRA_chr4_55133455_ENST00000257290_length(transcript)=5926nt_BP=440nt
GACTCCAGTTTAGCCGCCGCCGGAGAGGACGGGCGCCGAGCCGGGGCTGCGGACTTCGGCCTGCCCCTCACCTCACTCCCGCTGCTTGCA
CCTCCCGGATGGTGCTGACTGCTCCCTAAGCGGCGGCGGCGGCGAGTCGTGAGGACGCGCCGCGGAGGCTGTTCGGGGTCGAGGCTTCCC
GTCGCCGGCACTTCCTCTTGCGGCGCCCGTGCGCGGCCGGCCCGGCAGGCGGGATGGCGGCCGCGGCTCCAGGGAACGGCCGCGCATCGG
CGCCCCGGCTGCTTCTGCTCTTTCTGGTTCCGCTGCTGTGGGCCCCGGCTGCGGTCCGGGCCGGCCCAGATGAAGACCTTAGCCACCGGA
ACAAAGAACCGCCGGCGCCGGCCCAGCAGCTGCAGCCGCAGCCTGTGGCTGTGCAGGGCCCCGAGCCGGCCCGGGTCGAGAAAGGCAAAG
GCATCACAATGCTGGAAGAAATCAAAGTCCCATCCATCAAATTGGTGTACACTTTGACGGTCCCCGAGGCCACGGTGAAAGACAGTGGAG
ATTACGAATGTGCTGCCCGCCAGGCTACCAGGGAGGTCAAAGAAATGAAGAAAGTCACTATTTCTGTCCATGAGAAAGGTTTCATTGAAA
TCAAACCCACCTTCAGCCAGTTGGAAGCTGTCAACCTGCATGAAGTCAAACATTTTGTTGTAGAGGTGCGGGCCTACCCACCTCCCAGGA
TATCCTGGCTGAAAAACAATCTGACTCTGATTGAAAATCTCACTGAGATCACCACTGATGTGGAAAAGATTCAGGAAATAAGGTATCGAA
GCAAATTAAAGCTGATCCGTGCTAAGGAAGAAGACAGTGGCCATTATACTATTGTAGCTCAAAATGAAGATGCTGTGAAGAGCTATACTT
TTGAACTGTTAACTCAAGTTCCTTCATCCATTCTGGACTTGGTCGATGATCACCATGGCTCAACTGGGGGACAGACGGTGAGGTGCACAG
CTGAAGGCACGCCGCTTCCTGATATTGAGTGGATGATATGCAAAGATATTAAGAAATGTAATAATGAAACTTCCTGGACTATTTTGGCCA
ACAATGTCTCAAACATCATCACGGAGATCCACTCCCGAGACAGGAGTACCGTGGAGGGCCGTGTGACTTTCGCCAAAGTGGAGGAGACCA
TCGCCGTGCGATGCCTGGCTAAGAATCTCCTTGGAGCTGAGAACCGAGAGCTGAAGCTGGTGGCTCCCACCCTGCGTTCTGAACTCACGG
TGGCTGCTGCAGTCCTGGTGCTGTTGGTGATTGTGATCATCTCACTTATTGTCCTGGTTGTCATTTGGAAACAGAAACCGAGGTATGAAA
TTCGCTGGAGGGTCATTGAATCAATCAGCCCAGATGGACATGAATATATTTATGTGGACCCGATGCAGCTGCCTTATGACTCAAGATGGG
AGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGGGAAGGTGGTTGAAGGAACAGCCTATGGATTAAGCC
GGTCCCAACCTGTCATGAAAGTTGCAGTGAAGATGCTAAAACCCACGGCCAGATCCAGTGAAAAACAAGCTCTCATGTCTGAACTGAAGA
TAATGACTCACCTGGGGCCACATTTGAACATTGTAAACTTGCTGGGAGCCTGCACCAAGTCAGGCCCCATTTACATCATCACAGAGTATT
GCTTCTATGGAGATTTGGTCAACTATTTGCATAAGAATAGGGATAGCTTCCTGAGCCACCACCCAGAGAAGCCAAAGAAAGAGCTGGATA
TCTTTGGATTGAACCCTGCTGATGAAAGCACACGGAGCTATGTTATTTTATCTTTTGAAAACAATGGTGACTACATGGACATGAAGCAGG
CTGATACTACACAGTATGTCCCCATGCTAGAAAGGAAAGAGGTTTCTAAATATTCCGACATCCAGAGATCACTCTATGATCGTCCAGCCT
CATATAAGAAGAAATCTATGTTAGACTCAGAAGTCAAAAACCTCCTTTCAGATGATAACTCAGAAGGCCTTACTTTATTGGATTTGTTGA
GCTTCACCTATCAAGTTGCCCGAGGAATGGAGTTTTTGGCTTCAAAAAATTGTGTCCACCGTGATCTGGCTGCTCGCAACGTCCTCCTGG
CACAAGGAAAAATTGTGAAGATCTGTGACTTTGGCCTGGCCAGAGACATCATGCATGATTCGAACTATGTGTCGAAAGGCAGTACCTTTC
TGCCCGTGAAGTGGATGGCTCCTGAGAGCATCTTTGACAACCTCTACACCACACTGAGTGATGTCTGGTCTTATGGCATTCTGCTCTGGG
AGATCTTTTCCCTTGGTGGCACCCCTTACCCCGGCATGATGGTGGATTCTACTTTCTACAATAAGATCAAGAGTGGGTACCGGATGGCCA
AGCCTGACCACGCTACCAGTGAAGTCTACGAGATCATGGTGAAATGCTGGAACAGTGAGCCGGAGAAGAGACCCTCCTTTTACCACCTGA
GTGAGATTGTGGAGAATCTGCTGCCTGGACAATATAAAAAGAGTTATGAAAAAATTCACCTGGACTTCCTGAAGAGTGACCATCCTGCTG
TGGCACGCATGCGTGTGGACTCAGACAATGCATACATTGGTGTCACCTACAAAAACGAGGAAGACAAGCTGAAGGACTGGGAGGGTGGTC
TGGATGAGCAGAGACTGAGCGCTGACAGTGGCTACATCATTCCTCTGCCTGACATTGACCCTGTCCCTGAGGAGGAGGACCTGGGCAAGA
GGAACAGACACAGCTCGCAGACCTCTGAAGAGAGTGCCATTGAGACGGGTTCCAGCAGTTCCACCTTCATCAAGAGAGAGGACGAGACCA
TTGAAGACATCGACATGATGGATGACATCGGCATAGACTCTTCAGACCTGGTGGAAGACAGCTTCCTGTAACTGGCGGATTCGAGGGGTT
CCTTCCACTTCTGGGGCCACCTCTGGATCCCGTTCAGAAAACCACTTTATTGCAATGCAGAGGTTGAGAGGAGGACTTGGTTGATGTTTA
AAGAGAAGTTCCCAGCCAAGGGCCTCGGGGAGCGTTCTAAATATGAATGAATGGGATATTTTGAAATGAACTTTGTCAGTGTTGCCTCTT
GCAATGCCTCAGTAGCATCTCAGTGGTGTGTGAAGTTTGGAGATAGATGGATAAGGGAATAATAGGCCACAGAAGGTGAACTTTGTGCTT
CAAGGACATTGGTGAGAGTCCAACAGACACAATTTATACTGCGACAGAACTTCAGCATTGTAATTATGTAAATAACTCTAACCAAGGCTG
TGTTTAGATTGTATTAACTATCTTCTTTGGACTTCTGAAGAGACCACTCAATCCATCCATGTACTTCCCTCTTGAAACCTGATGTCAGCT
GCTGTTGAACTTTTTAAAGAAGTGCATGAAAAACCATTTTTGAACCTTAAAAGGTACTGGTACTATAGCATTTTGCTATCTTTTTTAGTG
TTAAAGAGATAAAGAATAATAATTAACCAACCTTGTTTAATAGATTTGGGTCATTTAGAAGCCTGACAACTCATTTTCATATTGTAATCT
ATGTTTATAATACTACTACTGTTATCAGTAATGCTAAATGTGTAATAATGTAACATGATTTCCCTCCAGAGAAAGCACAATTTAAAACAA
TCCTTACTAAGTAGGTGATGAGTTTGACAGTTTTTGACATTTATATTAAATAACATGTTTCTCTATAAAGTATGGTAATAGCTTTAGTGA
ATTAAATTTAGTTGAGCATAGAGAACAAAGTAAAAGTAGTGTTGTCCAGGAAGTCAGAATTTTTAACTGTACTGAATAGGTTCCCCAATC
CATCGTATTAAAAAACAATTAACTGCCCTCTGAAATAATGGGATTAGAAACAAACAAAACTCTTAAGTCCTAAAAGTTCTCAATGTAGAG
GCATAAACCTGTGCTGAACATAACTTCTCATGTATATTACCCAATGGAAAATATAATGATCAGCAAAAAGACTGGATTTGCAGAAGTTTT
TTTTTTTTTTTTCTTCATGCCTGATGAAAGCTTTGGCGACCCCAATATATGTATTTTTTGAATCTATGAACCTGAAAAGGGTCAGAAGGA
TGCCCAGACATCAGCCTCCTTCTTTCACCCCTTACCCCAAAGAGAAAGAGTTTGAAACTCGAGACCATAAAGATATTCTTTAGTGGAGGC
TGGATGTGCATTAGCCTGGATCCTCAGTTCTCAAATGTGTGTGGCAGCCAGGATGACTAGATCCTGGGTTTCCATCCTTGAGATTCTGAA
GTATGAAGTCTGAGGGAAACCAGAGTCTGTATTTTTCTAAACTCCCTGGCTGTTCTGATCGGCCAGTTTTCGGAAACACTGACTTAGGTT
TCAGGAAGTTGCCATGGGAAACAAATAATTTGAACTTTGGAACAGGGTTGGCATTCAACCACGCAGGAAGCCTACTATTTAAATCCTTGG
CTTCAGGTTAGTGACATTTAATGCCATCTAGCTAGCAATTGCGACCTTAATTTAACTTTCCAGTCTTAGCTGAGGCTGAGAAAGCTAAAG
TTTGGTTTTGACAGGTTTTCCAAAAGTAAAGATGCTACTTCCCACTGTATGGGGGAGATTGAACTTTCCCCGTCTCCCGTCTTCTGCCTC
CCACTCCATACCCCGCCAAGGAAAGGCATGTACAAAAATTATGCAATTCAGTGTTCCAAGTCTCTGTGTAACCAGCTCAGTGTTTTGGTG
GAAAAAACATTTTAAGTTTTACTGATAATTTGAGGTTAGATGGGAGGATGAATTGTCACATCTATCCACACTGTCAAACAGGTTGGTGTG
GGTTCATTGGCATTCTTTGCAATACTGCTTAATTGCTGATACCATATGAATGAAACATGGGCTGTGATTACTGCAATCACTGTGCTATCG
GCAGATGATGCTTTGGAAGATGCAGAAGCAATAATAAAGTACTTGACTACCTACTGGTGTAATCTCAATGCAAGCCCCAACTTTCTTATC
CAACTTTTTCATAGTAAGTGCGAAGACTGAGCCAGATTGGCCAATTAAAAACGAAAACCTGACTAGGTTCTGTAGAGCCAATTAGACTTG
AAATACGTTTGTGTTTCTAGAATCACAGCTCAAGCATTCTGTTTATCGCTCACTCTCCCTTGTACAGCCTTATTTTGTTGGTGCTTTGCA
TTTTGATATTGCTGTGAGCCTTGCATGACATCATGAGGCCGGATGAAACTTCTCAGTCCAGCAGTTTCCAGTCCTAACAAATGCTCCCAC
CTGAATTTGTATATGACTGCATTTGTGTGTGTGTGTGTGTTTTCAGCAAATTCCAGATTTGTTTCCTTTTGGCCTCCTGCAAAGTCTCCA
GAAGAAAATTTGCCAATCTTTCCTACTTTCTATTTTTATGATGACAATCAAAGCCGGCCTGAGAAACACTATTTGTGACTTTTTAAACGA
TTAGTGATGTCCTTAAAATGTGGTCTGCCAATCTGTACAAAATGGTCCTATTTTTGTGAAGAGGGACATAAGATAAAATGATGTTATACA
TCAATATGTATATATGTATTTCTATATAGACTTGGAGAATACTGCCAAAACATTTATGACAAGCTGTATCACTGCCTTCGTTTATATTTT
TTTAACTGTGATAATCCCCACAGGCACATTAACTGTTGCACTTTTGAATGTCCAAAATTTATATTTTAGAAATAATAAAAAGAAAGATAC
TTACATGTTCCCAAAACAATGGTGTGGTGAATGTGTGAGAAAAACTAACTTGATAGGGTCTACCAATACAAAATGTATTACGAATGCCCC

>91759_91759_1_TMEM165-PDGFRA_TMEM165_chr4_56262563_ENST00000381334_PDGFRA_chr4_55133455_ENST00000257290_length(amino acids)=930AA_BP=94
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEV
RAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTG
GQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAP
TLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVE
GTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPE
KPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEG
LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVW
SYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDF
LKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTF

--------------------------------------------------------------
>91759_91759_2_TMEM165-PDGFRA_TMEM165_chr4_56262563_ENST00000381334_PDGFRA_chr4_55133456_ENST00000257290_length(transcript)=5926nt_BP=440nt
GACTCCAGTTTAGCCGCCGCCGGAGAGGACGGGCGCCGAGCCGGGGCTGCGGACTTCGGCCTGCCCCTCACCTCACTCCCGCTGCTTGCA
CCTCCCGGATGGTGCTGACTGCTCCCTAAGCGGCGGCGGCGGCGAGTCGTGAGGACGCGCCGCGGAGGCTGTTCGGGGTCGAGGCTTCCC
GTCGCCGGCACTTCCTCTTGCGGCGCCCGTGCGCGGCCGGCCCGGCAGGCGGGATGGCGGCCGCGGCTCCAGGGAACGGCCGCGCATCGG
CGCCCCGGCTGCTTCTGCTCTTTCTGGTTCCGCTGCTGTGGGCCCCGGCTGCGGTCCGGGCCGGCCCAGATGAAGACCTTAGCCACCGGA
ACAAAGAACCGCCGGCGCCGGCCCAGCAGCTGCAGCCGCAGCCTGTGGCTGTGCAGGGCCCCGAGCCGGCCCGGGTCGAGAAAGGCAAAG
GCATCACAATGCTGGAAGAAATCAAAGTCCCATCCATCAAATTGGTGTACACTTTGACGGTCCCCGAGGCCACGGTGAAAGACAGTGGAG
ATTACGAATGTGCTGCCCGCCAGGCTACCAGGGAGGTCAAAGAAATGAAGAAAGTCACTATTTCTGTCCATGAGAAAGGTTTCATTGAAA
TCAAACCCACCTTCAGCCAGTTGGAAGCTGTCAACCTGCATGAAGTCAAACATTTTGTTGTAGAGGTGCGGGCCTACCCACCTCCCAGGA
TATCCTGGCTGAAAAACAATCTGACTCTGATTGAAAATCTCACTGAGATCACCACTGATGTGGAAAAGATTCAGGAAATAAGGTATCGAA
GCAAATTAAAGCTGATCCGTGCTAAGGAAGAAGACAGTGGCCATTATACTATTGTAGCTCAAAATGAAGATGCTGTGAAGAGCTATACTT
TTGAACTGTTAACTCAAGTTCCTTCATCCATTCTGGACTTGGTCGATGATCACCATGGCTCAACTGGGGGACAGACGGTGAGGTGCACAG
CTGAAGGCACGCCGCTTCCTGATATTGAGTGGATGATATGCAAAGATATTAAGAAATGTAATAATGAAACTTCCTGGACTATTTTGGCCA
ACAATGTCTCAAACATCATCACGGAGATCCACTCCCGAGACAGGAGTACCGTGGAGGGCCGTGTGACTTTCGCCAAAGTGGAGGAGACCA
TCGCCGTGCGATGCCTGGCTAAGAATCTCCTTGGAGCTGAGAACCGAGAGCTGAAGCTGGTGGCTCCCACCCTGCGTTCTGAACTCACGG
TGGCTGCTGCAGTCCTGGTGCTGTTGGTGATTGTGATCATCTCACTTATTGTCCTGGTTGTCATTTGGAAACAGAAACCGAGGTATGAAA
TTCGCTGGAGGGTCATTGAATCAATCAGCCCAGATGGACATGAATATATTTATGTGGACCCGATGCAGCTGCCTTATGACTCAAGATGGG
AGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGGGAAGGTGGTTGAAGGAACAGCCTATGGATTAAGCC
GGTCCCAACCTGTCATGAAAGTTGCAGTGAAGATGCTAAAACCCACGGCCAGATCCAGTGAAAAACAAGCTCTCATGTCTGAACTGAAGA
TAATGACTCACCTGGGGCCACATTTGAACATTGTAAACTTGCTGGGAGCCTGCACCAAGTCAGGCCCCATTTACATCATCACAGAGTATT
GCTTCTATGGAGATTTGGTCAACTATTTGCATAAGAATAGGGATAGCTTCCTGAGCCACCACCCAGAGAAGCCAAAGAAAGAGCTGGATA
TCTTTGGATTGAACCCTGCTGATGAAAGCACACGGAGCTATGTTATTTTATCTTTTGAAAACAATGGTGACTACATGGACATGAAGCAGG
CTGATACTACACAGTATGTCCCCATGCTAGAAAGGAAAGAGGTTTCTAAATATTCCGACATCCAGAGATCACTCTATGATCGTCCAGCCT
CATATAAGAAGAAATCTATGTTAGACTCAGAAGTCAAAAACCTCCTTTCAGATGATAACTCAGAAGGCCTTACTTTATTGGATTTGTTGA
GCTTCACCTATCAAGTTGCCCGAGGAATGGAGTTTTTGGCTTCAAAAAATTGTGTCCACCGTGATCTGGCTGCTCGCAACGTCCTCCTGG
CACAAGGAAAAATTGTGAAGATCTGTGACTTTGGCCTGGCCAGAGACATCATGCATGATTCGAACTATGTGTCGAAAGGCAGTACCTTTC
TGCCCGTGAAGTGGATGGCTCCTGAGAGCATCTTTGACAACCTCTACACCACACTGAGTGATGTCTGGTCTTATGGCATTCTGCTCTGGG
AGATCTTTTCCCTTGGTGGCACCCCTTACCCCGGCATGATGGTGGATTCTACTTTCTACAATAAGATCAAGAGTGGGTACCGGATGGCCA
AGCCTGACCACGCTACCAGTGAAGTCTACGAGATCATGGTGAAATGCTGGAACAGTGAGCCGGAGAAGAGACCCTCCTTTTACCACCTGA
GTGAGATTGTGGAGAATCTGCTGCCTGGACAATATAAAAAGAGTTATGAAAAAATTCACCTGGACTTCCTGAAGAGTGACCATCCTGCTG
TGGCACGCATGCGTGTGGACTCAGACAATGCATACATTGGTGTCACCTACAAAAACGAGGAAGACAAGCTGAAGGACTGGGAGGGTGGTC
TGGATGAGCAGAGACTGAGCGCTGACAGTGGCTACATCATTCCTCTGCCTGACATTGACCCTGTCCCTGAGGAGGAGGACCTGGGCAAGA
GGAACAGACACAGCTCGCAGACCTCTGAAGAGAGTGCCATTGAGACGGGTTCCAGCAGTTCCACCTTCATCAAGAGAGAGGACGAGACCA
TTGAAGACATCGACATGATGGATGACATCGGCATAGACTCTTCAGACCTGGTGGAAGACAGCTTCCTGTAACTGGCGGATTCGAGGGGTT
CCTTCCACTTCTGGGGCCACCTCTGGATCCCGTTCAGAAAACCACTTTATTGCAATGCAGAGGTTGAGAGGAGGACTTGGTTGATGTTTA
AAGAGAAGTTCCCAGCCAAGGGCCTCGGGGAGCGTTCTAAATATGAATGAATGGGATATTTTGAAATGAACTTTGTCAGTGTTGCCTCTT
GCAATGCCTCAGTAGCATCTCAGTGGTGTGTGAAGTTTGGAGATAGATGGATAAGGGAATAATAGGCCACAGAAGGTGAACTTTGTGCTT
CAAGGACATTGGTGAGAGTCCAACAGACACAATTTATACTGCGACAGAACTTCAGCATTGTAATTATGTAAATAACTCTAACCAAGGCTG
TGTTTAGATTGTATTAACTATCTTCTTTGGACTTCTGAAGAGACCACTCAATCCATCCATGTACTTCCCTCTTGAAACCTGATGTCAGCT
GCTGTTGAACTTTTTAAAGAAGTGCATGAAAAACCATTTTTGAACCTTAAAAGGTACTGGTACTATAGCATTTTGCTATCTTTTTTAGTG
TTAAAGAGATAAAGAATAATAATTAACCAACCTTGTTTAATAGATTTGGGTCATTTAGAAGCCTGACAACTCATTTTCATATTGTAATCT
ATGTTTATAATACTACTACTGTTATCAGTAATGCTAAATGTGTAATAATGTAACATGATTTCCCTCCAGAGAAAGCACAATTTAAAACAA
TCCTTACTAAGTAGGTGATGAGTTTGACAGTTTTTGACATTTATATTAAATAACATGTTTCTCTATAAAGTATGGTAATAGCTTTAGTGA
ATTAAATTTAGTTGAGCATAGAGAACAAAGTAAAAGTAGTGTTGTCCAGGAAGTCAGAATTTTTAACTGTACTGAATAGGTTCCCCAATC
CATCGTATTAAAAAACAATTAACTGCCCTCTGAAATAATGGGATTAGAAACAAACAAAACTCTTAAGTCCTAAAAGTTCTCAATGTAGAG
GCATAAACCTGTGCTGAACATAACTTCTCATGTATATTACCCAATGGAAAATATAATGATCAGCAAAAAGACTGGATTTGCAGAAGTTTT
TTTTTTTTTTTTCTTCATGCCTGATGAAAGCTTTGGCGACCCCAATATATGTATTTTTTGAATCTATGAACCTGAAAAGGGTCAGAAGGA
TGCCCAGACATCAGCCTCCTTCTTTCACCCCTTACCCCAAAGAGAAAGAGTTTGAAACTCGAGACCATAAAGATATTCTTTAGTGGAGGC
TGGATGTGCATTAGCCTGGATCCTCAGTTCTCAAATGTGTGTGGCAGCCAGGATGACTAGATCCTGGGTTTCCATCCTTGAGATTCTGAA
GTATGAAGTCTGAGGGAAACCAGAGTCTGTATTTTTCTAAACTCCCTGGCTGTTCTGATCGGCCAGTTTTCGGAAACACTGACTTAGGTT
TCAGGAAGTTGCCATGGGAAACAAATAATTTGAACTTTGGAACAGGGTTGGCATTCAACCACGCAGGAAGCCTACTATTTAAATCCTTGG
CTTCAGGTTAGTGACATTTAATGCCATCTAGCTAGCAATTGCGACCTTAATTTAACTTTCCAGTCTTAGCTGAGGCTGAGAAAGCTAAAG
TTTGGTTTTGACAGGTTTTCCAAAAGTAAAGATGCTACTTCCCACTGTATGGGGGAGATTGAACTTTCCCCGTCTCCCGTCTTCTGCCTC
CCACTCCATACCCCGCCAAGGAAAGGCATGTACAAAAATTATGCAATTCAGTGTTCCAAGTCTCTGTGTAACCAGCTCAGTGTTTTGGTG
GAAAAAACATTTTAAGTTTTACTGATAATTTGAGGTTAGATGGGAGGATGAATTGTCACATCTATCCACACTGTCAAACAGGTTGGTGTG
GGTTCATTGGCATTCTTTGCAATACTGCTTAATTGCTGATACCATATGAATGAAACATGGGCTGTGATTACTGCAATCACTGTGCTATCG
GCAGATGATGCTTTGGAAGATGCAGAAGCAATAATAAAGTACTTGACTACCTACTGGTGTAATCTCAATGCAAGCCCCAACTTTCTTATC
CAACTTTTTCATAGTAAGTGCGAAGACTGAGCCAGATTGGCCAATTAAAAACGAAAACCTGACTAGGTTCTGTAGAGCCAATTAGACTTG
AAATACGTTTGTGTTTCTAGAATCACAGCTCAAGCATTCTGTTTATCGCTCACTCTCCCTTGTACAGCCTTATTTTGTTGGTGCTTTGCA
TTTTGATATTGCTGTGAGCCTTGCATGACATCATGAGGCCGGATGAAACTTCTCAGTCCAGCAGTTTCCAGTCCTAACAAATGCTCCCAC
CTGAATTTGTATATGACTGCATTTGTGTGTGTGTGTGTGTTTTCAGCAAATTCCAGATTTGTTTCCTTTTGGCCTCCTGCAAAGTCTCCA
GAAGAAAATTTGCCAATCTTTCCTACTTTCTATTTTTATGATGACAATCAAAGCCGGCCTGAGAAACACTATTTGTGACTTTTTAAACGA
TTAGTGATGTCCTTAAAATGTGGTCTGCCAATCTGTACAAAATGGTCCTATTTTTGTGAAGAGGGACATAAGATAAAATGATGTTATACA
TCAATATGTATATATGTATTTCTATATAGACTTGGAGAATACTGCCAAAACATTTATGACAAGCTGTATCACTGCCTTCGTTTATATTTT
TTTAACTGTGATAATCCCCACAGGCACATTAACTGTTGCACTTTTGAATGTCCAAAATTTATATTTTAGAAATAATAAAAAGAAAGATAC
TTACATGTTCCCAAAACAATGGTGTGGTGAATGTGTGAGAAAAACTAACTTGATAGGGTCTACCAATACAAAATGTATTACGAATGCCCC

>91759_91759_2_TMEM165-PDGFRA_TMEM165_chr4_56262563_ENST00000381334_PDGFRA_chr4_55133456_ENST00000257290_length(amino acids)=930AA_BP=94
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEV
RAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTG
GQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAP
TLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVE
GTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPE
KPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEG
LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVW
SYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDF
LKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTF

--------------------------------------------------------------
>91759_91759_3_TMEM165-PDGFRA_TMEM165_chr4_56262563_ENST00000506198_PDGFRA_chr4_55133455_ENST00000257290_length(transcript)=5926nt_BP=440nt
GACTCCAGTTTAGCCGCCGCCGGAGAGGACGGGCGCCGAGCCGGGGCTGCGGACTTCGGCCTGCCCCTCACCTCACTCCCGCTGCTTGCA
CCTCCCGGATGGTGCTGACTGCTCCCTAAGCGGCGGCGGCGGCGAGTCGTGAGGACGCGCCGCGGAGGCTGTTCGGGGTCGAGGCTTCCC
GTCGCCGGCACTTCCTCTTGCGGCGCCCGTGCGCGGCCGGCCCGGCAGGCGGGATGGCGGCCGCGGCTCCAGGGAACGGCCGCGCATCGG
CGCCCCGGCTGCTTCTGCTCTTTCTGGTTCCGCTGCTGTGGGCCCCGGCTGCGGTCCGGGCCGGCCCAGATGAAGACCTTAGCCACCGGA
ACAAAGAACCGCCGGCGCCGGCCCAGCAGCTGCAGCCGCAGCCTGTGGCTGTGCAGGGCCCCGAGCCGGCCCGGGTCGAGAAAGGCAAAG
GCATCACAATGCTGGAAGAAATCAAAGTCCCATCCATCAAATTGGTGTACACTTTGACGGTCCCCGAGGCCACGGTGAAAGACAGTGGAG
ATTACGAATGTGCTGCCCGCCAGGCTACCAGGGAGGTCAAAGAAATGAAGAAAGTCACTATTTCTGTCCATGAGAAAGGTTTCATTGAAA
TCAAACCCACCTTCAGCCAGTTGGAAGCTGTCAACCTGCATGAAGTCAAACATTTTGTTGTAGAGGTGCGGGCCTACCCACCTCCCAGGA
TATCCTGGCTGAAAAACAATCTGACTCTGATTGAAAATCTCACTGAGATCACCACTGATGTGGAAAAGATTCAGGAAATAAGGTATCGAA
GCAAATTAAAGCTGATCCGTGCTAAGGAAGAAGACAGTGGCCATTATACTATTGTAGCTCAAAATGAAGATGCTGTGAAGAGCTATACTT
TTGAACTGTTAACTCAAGTTCCTTCATCCATTCTGGACTTGGTCGATGATCACCATGGCTCAACTGGGGGACAGACGGTGAGGTGCACAG
CTGAAGGCACGCCGCTTCCTGATATTGAGTGGATGATATGCAAAGATATTAAGAAATGTAATAATGAAACTTCCTGGACTATTTTGGCCA
ACAATGTCTCAAACATCATCACGGAGATCCACTCCCGAGACAGGAGTACCGTGGAGGGCCGTGTGACTTTCGCCAAAGTGGAGGAGACCA
TCGCCGTGCGATGCCTGGCTAAGAATCTCCTTGGAGCTGAGAACCGAGAGCTGAAGCTGGTGGCTCCCACCCTGCGTTCTGAACTCACGG
TGGCTGCTGCAGTCCTGGTGCTGTTGGTGATTGTGATCATCTCACTTATTGTCCTGGTTGTCATTTGGAAACAGAAACCGAGGTATGAAA
TTCGCTGGAGGGTCATTGAATCAATCAGCCCAGATGGACATGAATATATTTATGTGGACCCGATGCAGCTGCCTTATGACTCAAGATGGG
AGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGGGAAGGTGGTTGAAGGAACAGCCTATGGATTAAGCC
GGTCCCAACCTGTCATGAAAGTTGCAGTGAAGATGCTAAAACCCACGGCCAGATCCAGTGAAAAACAAGCTCTCATGTCTGAACTGAAGA
TAATGACTCACCTGGGGCCACATTTGAACATTGTAAACTTGCTGGGAGCCTGCACCAAGTCAGGCCCCATTTACATCATCACAGAGTATT
GCTTCTATGGAGATTTGGTCAACTATTTGCATAAGAATAGGGATAGCTTCCTGAGCCACCACCCAGAGAAGCCAAAGAAAGAGCTGGATA
TCTTTGGATTGAACCCTGCTGATGAAAGCACACGGAGCTATGTTATTTTATCTTTTGAAAACAATGGTGACTACATGGACATGAAGCAGG
CTGATACTACACAGTATGTCCCCATGCTAGAAAGGAAAGAGGTTTCTAAATATTCCGACATCCAGAGATCACTCTATGATCGTCCAGCCT
CATATAAGAAGAAATCTATGTTAGACTCAGAAGTCAAAAACCTCCTTTCAGATGATAACTCAGAAGGCCTTACTTTATTGGATTTGTTGA
GCTTCACCTATCAAGTTGCCCGAGGAATGGAGTTTTTGGCTTCAAAAAATTGTGTCCACCGTGATCTGGCTGCTCGCAACGTCCTCCTGG
CACAAGGAAAAATTGTGAAGATCTGTGACTTTGGCCTGGCCAGAGACATCATGCATGATTCGAACTATGTGTCGAAAGGCAGTACCTTTC
TGCCCGTGAAGTGGATGGCTCCTGAGAGCATCTTTGACAACCTCTACACCACACTGAGTGATGTCTGGTCTTATGGCATTCTGCTCTGGG
AGATCTTTTCCCTTGGTGGCACCCCTTACCCCGGCATGATGGTGGATTCTACTTTCTACAATAAGATCAAGAGTGGGTACCGGATGGCCA
AGCCTGACCACGCTACCAGTGAAGTCTACGAGATCATGGTGAAATGCTGGAACAGTGAGCCGGAGAAGAGACCCTCCTTTTACCACCTGA
GTGAGATTGTGGAGAATCTGCTGCCTGGACAATATAAAAAGAGTTATGAAAAAATTCACCTGGACTTCCTGAAGAGTGACCATCCTGCTG
TGGCACGCATGCGTGTGGACTCAGACAATGCATACATTGGTGTCACCTACAAAAACGAGGAAGACAAGCTGAAGGACTGGGAGGGTGGTC
TGGATGAGCAGAGACTGAGCGCTGACAGTGGCTACATCATTCCTCTGCCTGACATTGACCCTGTCCCTGAGGAGGAGGACCTGGGCAAGA
GGAACAGACACAGCTCGCAGACCTCTGAAGAGAGTGCCATTGAGACGGGTTCCAGCAGTTCCACCTTCATCAAGAGAGAGGACGAGACCA
TTGAAGACATCGACATGATGGATGACATCGGCATAGACTCTTCAGACCTGGTGGAAGACAGCTTCCTGTAACTGGCGGATTCGAGGGGTT
CCTTCCACTTCTGGGGCCACCTCTGGATCCCGTTCAGAAAACCACTTTATTGCAATGCAGAGGTTGAGAGGAGGACTTGGTTGATGTTTA
AAGAGAAGTTCCCAGCCAAGGGCCTCGGGGAGCGTTCTAAATATGAATGAATGGGATATTTTGAAATGAACTTTGTCAGTGTTGCCTCTT
GCAATGCCTCAGTAGCATCTCAGTGGTGTGTGAAGTTTGGAGATAGATGGATAAGGGAATAATAGGCCACAGAAGGTGAACTTTGTGCTT
CAAGGACATTGGTGAGAGTCCAACAGACACAATTTATACTGCGACAGAACTTCAGCATTGTAATTATGTAAATAACTCTAACCAAGGCTG
TGTTTAGATTGTATTAACTATCTTCTTTGGACTTCTGAAGAGACCACTCAATCCATCCATGTACTTCCCTCTTGAAACCTGATGTCAGCT
GCTGTTGAACTTTTTAAAGAAGTGCATGAAAAACCATTTTTGAACCTTAAAAGGTACTGGTACTATAGCATTTTGCTATCTTTTTTAGTG
TTAAAGAGATAAAGAATAATAATTAACCAACCTTGTTTAATAGATTTGGGTCATTTAGAAGCCTGACAACTCATTTTCATATTGTAATCT
ATGTTTATAATACTACTACTGTTATCAGTAATGCTAAATGTGTAATAATGTAACATGATTTCCCTCCAGAGAAAGCACAATTTAAAACAA
TCCTTACTAAGTAGGTGATGAGTTTGACAGTTTTTGACATTTATATTAAATAACATGTTTCTCTATAAAGTATGGTAATAGCTTTAGTGA
ATTAAATTTAGTTGAGCATAGAGAACAAAGTAAAAGTAGTGTTGTCCAGGAAGTCAGAATTTTTAACTGTACTGAATAGGTTCCCCAATC
CATCGTATTAAAAAACAATTAACTGCCCTCTGAAATAATGGGATTAGAAACAAACAAAACTCTTAAGTCCTAAAAGTTCTCAATGTAGAG
GCATAAACCTGTGCTGAACATAACTTCTCATGTATATTACCCAATGGAAAATATAATGATCAGCAAAAAGACTGGATTTGCAGAAGTTTT
TTTTTTTTTTTTCTTCATGCCTGATGAAAGCTTTGGCGACCCCAATATATGTATTTTTTGAATCTATGAACCTGAAAAGGGTCAGAAGGA
TGCCCAGACATCAGCCTCCTTCTTTCACCCCTTACCCCAAAGAGAAAGAGTTTGAAACTCGAGACCATAAAGATATTCTTTAGTGGAGGC
TGGATGTGCATTAGCCTGGATCCTCAGTTCTCAAATGTGTGTGGCAGCCAGGATGACTAGATCCTGGGTTTCCATCCTTGAGATTCTGAA
GTATGAAGTCTGAGGGAAACCAGAGTCTGTATTTTTCTAAACTCCCTGGCTGTTCTGATCGGCCAGTTTTCGGAAACACTGACTTAGGTT
TCAGGAAGTTGCCATGGGAAACAAATAATTTGAACTTTGGAACAGGGTTGGCATTCAACCACGCAGGAAGCCTACTATTTAAATCCTTGG
CTTCAGGTTAGTGACATTTAATGCCATCTAGCTAGCAATTGCGACCTTAATTTAACTTTCCAGTCTTAGCTGAGGCTGAGAAAGCTAAAG
TTTGGTTTTGACAGGTTTTCCAAAAGTAAAGATGCTACTTCCCACTGTATGGGGGAGATTGAACTTTCCCCGTCTCCCGTCTTCTGCCTC
CCACTCCATACCCCGCCAAGGAAAGGCATGTACAAAAATTATGCAATTCAGTGTTCCAAGTCTCTGTGTAACCAGCTCAGTGTTTTGGTG
GAAAAAACATTTTAAGTTTTACTGATAATTTGAGGTTAGATGGGAGGATGAATTGTCACATCTATCCACACTGTCAAACAGGTTGGTGTG
GGTTCATTGGCATTCTTTGCAATACTGCTTAATTGCTGATACCATATGAATGAAACATGGGCTGTGATTACTGCAATCACTGTGCTATCG
GCAGATGATGCTTTGGAAGATGCAGAAGCAATAATAAAGTACTTGACTACCTACTGGTGTAATCTCAATGCAAGCCCCAACTTTCTTATC
CAACTTTTTCATAGTAAGTGCGAAGACTGAGCCAGATTGGCCAATTAAAAACGAAAACCTGACTAGGTTCTGTAGAGCCAATTAGACTTG
AAATACGTTTGTGTTTCTAGAATCACAGCTCAAGCATTCTGTTTATCGCTCACTCTCCCTTGTACAGCCTTATTTTGTTGGTGCTTTGCA
TTTTGATATTGCTGTGAGCCTTGCATGACATCATGAGGCCGGATGAAACTTCTCAGTCCAGCAGTTTCCAGTCCTAACAAATGCTCCCAC
CTGAATTTGTATATGACTGCATTTGTGTGTGTGTGTGTGTTTTCAGCAAATTCCAGATTTGTTTCCTTTTGGCCTCCTGCAAAGTCTCCA
GAAGAAAATTTGCCAATCTTTCCTACTTTCTATTTTTATGATGACAATCAAAGCCGGCCTGAGAAACACTATTTGTGACTTTTTAAACGA
TTAGTGATGTCCTTAAAATGTGGTCTGCCAATCTGTACAAAATGGTCCTATTTTTGTGAAGAGGGACATAAGATAAAATGATGTTATACA
TCAATATGTATATATGTATTTCTATATAGACTTGGAGAATACTGCCAAAACATTTATGACAAGCTGTATCACTGCCTTCGTTTATATTTT
TTTAACTGTGATAATCCCCACAGGCACATTAACTGTTGCACTTTTGAATGTCCAAAATTTATATTTTAGAAATAATAAAAAGAAAGATAC
TTACATGTTCCCAAAACAATGGTGTGGTGAATGTGTGAGAAAAACTAACTTGATAGGGTCTACCAATACAAAATGTATTACGAATGCCCC

>91759_91759_3_TMEM165-PDGFRA_TMEM165_chr4_56262563_ENST00000506198_PDGFRA_chr4_55133455_ENST00000257290_length(amino acids)=930AA_BP=94
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEV
RAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTG
GQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAP
TLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVE
GTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPE
KPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEG
LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVW
SYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDF
LKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTF

--------------------------------------------------------------
>91759_91759_4_TMEM165-PDGFRA_TMEM165_chr4_56262563_ENST00000506198_PDGFRA_chr4_55133456_ENST00000257290_length(transcript)=5926nt_BP=440nt
GACTCCAGTTTAGCCGCCGCCGGAGAGGACGGGCGCCGAGCCGGGGCTGCGGACTTCGGCCTGCCCCTCACCTCACTCCCGCTGCTTGCA
CCTCCCGGATGGTGCTGACTGCTCCCTAAGCGGCGGCGGCGGCGAGTCGTGAGGACGCGCCGCGGAGGCTGTTCGGGGTCGAGGCTTCCC
GTCGCCGGCACTTCCTCTTGCGGCGCCCGTGCGCGGCCGGCCCGGCAGGCGGGATGGCGGCCGCGGCTCCAGGGAACGGCCGCGCATCGG
CGCCCCGGCTGCTTCTGCTCTTTCTGGTTCCGCTGCTGTGGGCCCCGGCTGCGGTCCGGGCCGGCCCAGATGAAGACCTTAGCCACCGGA
ACAAAGAACCGCCGGCGCCGGCCCAGCAGCTGCAGCCGCAGCCTGTGGCTGTGCAGGGCCCCGAGCCGGCCCGGGTCGAGAAAGGCAAAG
GCATCACAATGCTGGAAGAAATCAAAGTCCCATCCATCAAATTGGTGTACACTTTGACGGTCCCCGAGGCCACGGTGAAAGACAGTGGAG
ATTACGAATGTGCTGCCCGCCAGGCTACCAGGGAGGTCAAAGAAATGAAGAAAGTCACTATTTCTGTCCATGAGAAAGGTTTCATTGAAA
TCAAACCCACCTTCAGCCAGTTGGAAGCTGTCAACCTGCATGAAGTCAAACATTTTGTTGTAGAGGTGCGGGCCTACCCACCTCCCAGGA
TATCCTGGCTGAAAAACAATCTGACTCTGATTGAAAATCTCACTGAGATCACCACTGATGTGGAAAAGATTCAGGAAATAAGGTATCGAA
GCAAATTAAAGCTGATCCGTGCTAAGGAAGAAGACAGTGGCCATTATACTATTGTAGCTCAAAATGAAGATGCTGTGAAGAGCTATACTT
TTGAACTGTTAACTCAAGTTCCTTCATCCATTCTGGACTTGGTCGATGATCACCATGGCTCAACTGGGGGACAGACGGTGAGGTGCACAG
CTGAAGGCACGCCGCTTCCTGATATTGAGTGGATGATATGCAAAGATATTAAGAAATGTAATAATGAAACTTCCTGGACTATTTTGGCCA
ACAATGTCTCAAACATCATCACGGAGATCCACTCCCGAGACAGGAGTACCGTGGAGGGCCGTGTGACTTTCGCCAAAGTGGAGGAGACCA
TCGCCGTGCGATGCCTGGCTAAGAATCTCCTTGGAGCTGAGAACCGAGAGCTGAAGCTGGTGGCTCCCACCCTGCGTTCTGAACTCACGG
TGGCTGCTGCAGTCCTGGTGCTGTTGGTGATTGTGATCATCTCACTTATTGTCCTGGTTGTCATTTGGAAACAGAAACCGAGGTATGAAA
TTCGCTGGAGGGTCATTGAATCAATCAGCCCAGATGGACATGAATATATTTATGTGGACCCGATGCAGCTGCCTTATGACTCAAGATGGG
AGTTTCCAAGAGATGGACTAGTGCTTGGTCGGGTCTTGGGGTCTGGAGCGTTTGGGAAGGTGGTTGAAGGAACAGCCTATGGATTAAGCC
GGTCCCAACCTGTCATGAAAGTTGCAGTGAAGATGCTAAAACCCACGGCCAGATCCAGTGAAAAACAAGCTCTCATGTCTGAACTGAAGA
TAATGACTCACCTGGGGCCACATTTGAACATTGTAAACTTGCTGGGAGCCTGCACCAAGTCAGGCCCCATTTACATCATCACAGAGTATT
GCTTCTATGGAGATTTGGTCAACTATTTGCATAAGAATAGGGATAGCTTCCTGAGCCACCACCCAGAGAAGCCAAAGAAAGAGCTGGATA
TCTTTGGATTGAACCCTGCTGATGAAAGCACACGGAGCTATGTTATTTTATCTTTTGAAAACAATGGTGACTACATGGACATGAAGCAGG
CTGATACTACACAGTATGTCCCCATGCTAGAAAGGAAAGAGGTTTCTAAATATTCCGACATCCAGAGATCACTCTATGATCGTCCAGCCT
CATATAAGAAGAAATCTATGTTAGACTCAGAAGTCAAAAACCTCCTTTCAGATGATAACTCAGAAGGCCTTACTTTATTGGATTTGTTGA
GCTTCACCTATCAAGTTGCCCGAGGAATGGAGTTTTTGGCTTCAAAAAATTGTGTCCACCGTGATCTGGCTGCTCGCAACGTCCTCCTGG
CACAAGGAAAAATTGTGAAGATCTGTGACTTTGGCCTGGCCAGAGACATCATGCATGATTCGAACTATGTGTCGAAAGGCAGTACCTTTC
TGCCCGTGAAGTGGATGGCTCCTGAGAGCATCTTTGACAACCTCTACACCACACTGAGTGATGTCTGGTCTTATGGCATTCTGCTCTGGG
AGATCTTTTCCCTTGGTGGCACCCCTTACCCCGGCATGATGGTGGATTCTACTTTCTACAATAAGATCAAGAGTGGGTACCGGATGGCCA
AGCCTGACCACGCTACCAGTGAAGTCTACGAGATCATGGTGAAATGCTGGAACAGTGAGCCGGAGAAGAGACCCTCCTTTTACCACCTGA
GTGAGATTGTGGAGAATCTGCTGCCTGGACAATATAAAAAGAGTTATGAAAAAATTCACCTGGACTTCCTGAAGAGTGACCATCCTGCTG
TGGCACGCATGCGTGTGGACTCAGACAATGCATACATTGGTGTCACCTACAAAAACGAGGAAGACAAGCTGAAGGACTGGGAGGGTGGTC
TGGATGAGCAGAGACTGAGCGCTGACAGTGGCTACATCATTCCTCTGCCTGACATTGACCCTGTCCCTGAGGAGGAGGACCTGGGCAAGA
GGAACAGACACAGCTCGCAGACCTCTGAAGAGAGTGCCATTGAGACGGGTTCCAGCAGTTCCACCTTCATCAAGAGAGAGGACGAGACCA
TTGAAGACATCGACATGATGGATGACATCGGCATAGACTCTTCAGACCTGGTGGAAGACAGCTTCCTGTAACTGGCGGATTCGAGGGGTT
CCTTCCACTTCTGGGGCCACCTCTGGATCCCGTTCAGAAAACCACTTTATTGCAATGCAGAGGTTGAGAGGAGGACTTGGTTGATGTTTA
AAGAGAAGTTCCCAGCCAAGGGCCTCGGGGAGCGTTCTAAATATGAATGAATGGGATATTTTGAAATGAACTTTGTCAGTGTTGCCTCTT
GCAATGCCTCAGTAGCATCTCAGTGGTGTGTGAAGTTTGGAGATAGATGGATAAGGGAATAATAGGCCACAGAAGGTGAACTTTGTGCTT
CAAGGACATTGGTGAGAGTCCAACAGACACAATTTATACTGCGACAGAACTTCAGCATTGTAATTATGTAAATAACTCTAACCAAGGCTG
TGTTTAGATTGTATTAACTATCTTCTTTGGACTTCTGAAGAGACCACTCAATCCATCCATGTACTTCCCTCTTGAAACCTGATGTCAGCT
GCTGTTGAACTTTTTAAAGAAGTGCATGAAAAACCATTTTTGAACCTTAAAAGGTACTGGTACTATAGCATTTTGCTATCTTTTTTAGTG
TTAAAGAGATAAAGAATAATAATTAACCAACCTTGTTTAATAGATTTGGGTCATTTAGAAGCCTGACAACTCATTTTCATATTGTAATCT
ATGTTTATAATACTACTACTGTTATCAGTAATGCTAAATGTGTAATAATGTAACATGATTTCCCTCCAGAGAAAGCACAATTTAAAACAA
TCCTTACTAAGTAGGTGATGAGTTTGACAGTTTTTGACATTTATATTAAATAACATGTTTCTCTATAAAGTATGGTAATAGCTTTAGTGA
ATTAAATTTAGTTGAGCATAGAGAACAAAGTAAAAGTAGTGTTGTCCAGGAAGTCAGAATTTTTAACTGTACTGAATAGGTTCCCCAATC
CATCGTATTAAAAAACAATTAACTGCCCTCTGAAATAATGGGATTAGAAACAAACAAAACTCTTAAGTCCTAAAAGTTCTCAATGTAGAG
GCATAAACCTGTGCTGAACATAACTTCTCATGTATATTACCCAATGGAAAATATAATGATCAGCAAAAAGACTGGATTTGCAGAAGTTTT
TTTTTTTTTTTTCTTCATGCCTGATGAAAGCTTTGGCGACCCCAATATATGTATTTTTTGAATCTATGAACCTGAAAAGGGTCAGAAGGA
TGCCCAGACATCAGCCTCCTTCTTTCACCCCTTACCCCAAAGAGAAAGAGTTTGAAACTCGAGACCATAAAGATATTCTTTAGTGGAGGC
TGGATGTGCATTAGCCTGGATCCTCAGTTCTCAAATGTGTGTGGCAGCCAGGATGACTAGATCCTGGGTTTCCATCCTTGAGATTCTGAA
GTATGAAGTCTGAGGGAAACCAGAGTCTGTATTTTTCTAAACTCCCTGGCTGTTCTGATCGGCCAGTTTTCGGAAACACTGACTTAGGTT
TCAGGAAGTTGCCATGGGAAACAAATAATTTGAACTTTGGAACAGGGTTGGCATTCAACCACGCAGGAAGCCTACTATTTAAATCCTTGG
CTTCAGGTTAGTGACATTTAATGCCATCTAGCTAGCAATTGCGACCTTAATTTAACTTTCCAGTCTTAGCTGAGGCTGAGAAAGCTAAAG
TTTGGTTTTGACAGGTTTTCCAAAAGTAAAGATGCTACTTCCCACTGTATGGGGGAGATTGAACTTTCCCCGTCTCCCGTCTTCTGCCTC
CCACTCCATACCCCGCCAAGGAAAGGCATGTACAAAAATTATGCAATTCAGTGTTCCAAGTCTCTGTGTAACCAGCTCAGTGTTTTGGTG
GAAAAAACATTTTAAGTTTTACTGATAATTTGAGGTTAGATGGGAGGATGAATTGTCACATCTATCCACACTGTCAAACAGGTTGGTGTG
GGTTCATTGGCATTCTTTGCAATACTGCTTAATTGCTGATACCATATGAATGAAACATGGGCTGTGATTACTGCAATCACTGTGCTATCG
GCAGATGATGCTTTGGAAGATGCAGAAGCAATAATAAAGTACTTGACTACCTACTGGTGTAATCTCAATGCAAGCCCCAACTTTCTTATC
CAACTTTTTCATAGTAAGTGCGAAGACTGAGCCAGATTGGCCAATTAAAAACGAAAACCTGACTAGGTTCTGTAGAGCCAATTAGACTTG
AAATACGTTTGTGTTTCTAGAATCACAGCTCAAGCATTCTGTTTATCGCTCACTCTCCCTTGTACAGCCTTATTTTGTTGGTGCTTTGCA
TTTTGATATTGCTGTGAGCCTTGCATGACATCATGAGGCCGGATGAAACTTCTCAGTCCAGCAGTTTCCAGTCCTAACAAATGCTCCCAC
CTGAATTTGTATATGACTGCATTTGTGTGTGTGTGTGTGTTTTCAGCAAATTCCAGATTTGTTTCCTTTTGGCCTCCTGCAAAGTCTCCA
GAAGAAAATTTGCCAATCTTTCCTACTTTCTATTTTTATGATGACAATCAAAGCCGGCCTGAGAAACACTATTTGTGACTTTTTAAACGA
TTAGTGATGTCCTTAAAATGTGGTCTGCCAATCTGTACAAAATGGTCCTATTTTTGTGAAGAGGGACATAAGATAAAATGATGTTATACA
TCAATATGTATATATGTATTTCTATATAGACTTGGAGAATACTGCCAAAACATTTATGACAAGCTGTATCACTGCCTTCGTTTATATTTT
TTTAACTGTGATAATCCCCACAGGCACATTAACTGTTGCACTTTTGAATGTCCAAAATTTATATTTTAGAAATAATAAAAAGAAAGATAC
TTACATGTTCCCAAAACAATGGTGTGGTGAATGTGTGAGAAAAACTAACTTGATAGGGTCTACCAATACAAAATGTATTACGAATGCCCC

>91759_91759_4_TMEM165-PDGFRA_TMEM165_chr4_56262563_ENST00000506198_PDGFRA_chr4_55133456_ENST00000257290_length(amino acids)=930AA_BP=94
MFGVEASRRRHFLLRRPCAAGPAGGMAAAAPGNGRASAPRLLLLFLVPLLWAPAAVRAGPDEDLSHRNKEPPAPAQQLQPQPVAVQGPEP
ARVEKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEV
RAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTG
GQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAP
TLRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVE
GTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPE
KPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEG
LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVW
SYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDF
LKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYIIPLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TMEM165-PDGFRA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM165-PDGFRA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM165-PDGFRA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource