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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM170A-VAT1L (FusionGDB2 ID:91781)

Fusion Gene Summary for TMEM170A-VAT1L

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM170A-VAT1L
	Fusion gene ID: 91781
		Hgene	Tgene
	Gene symbol	TMEM170A	VAT1L
	Gene ID	124491	57687
	Gene name	transmembrane protein 170A	vesicle amine transport 1 like
	Synonyms	TMEM170	-
	Cytomap	16q23.1	16q23.1
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 170Atransmembrane protein 170	synaptic vesicle membrane protein VAT-1 homolog-likevesicle amine transport protein 1 homolog (T. californica)-likevesicle amine transport protein 1 homolog-like (T. californica)
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000357613, ENST00000561878, ENST00000569276, ENST00000566980, ENST00000567796, ENST00000569540,	ENST00000563850, ENST00000302536,
Fusion gene scores	* DoF score	7 X 6 X 7=294	7 X 7 X 5=245
	# samples	9	9
	** MAII score	log2(9/294*10)=-1.70781924850669 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/245*10)=-1.4447848426729 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM170A [Title/Abstract] AND VAT1L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM170A(75498366)-VAT1L(78005747), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across TMEM170A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VAT1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-8574-01A	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+

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Fusion Gene ORF analysis for TMEM170A-VAT1L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000357613	ENST00000563850	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
5CDS-intron	ENST00000561878	ENST00000563850	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
5CDS-intron	ENST00000569276	ENST00000563850	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
In-frame	ENST00000357613	ENST00000302536	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
In-frame	ENST00000561878	ENST00000302536	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
In-frame	ENST00000569276	ENST00000302536	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
intron-3CDS	ENST00000566980	ENST00000302536	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
intron-3CDS	ENST00000567796	ENST00000302536	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
intron-3CDS	ENST00000569540	ENST00000302536	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
intron-intron	ENST00000566980	ENST00000563850	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
intron-intron	ENST00000567796	ENST00000563850	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+
intron-intron	ENST00000569540	ENST00000563850	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000357613	TMEM170A	chr16	75498366	-	ENST00000302536	VAT1L	chr16	78005747	+	2817	222	746	270	158
ENST00000561878	TMEM170A	chr16	75498366	-	ENST00000302536	VAT1L	chr16	78005747	+	2826	231	755	279	158
ENST00000569276	TMEM170A	chr16	75498366	-	ENST00000302536	VAT1L	chr16	78005747	+	2800	205	729	253	158

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000357613	ENST00000302536	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+	0.6542599	0.34574008
ENST00000561878	ENST00000302536	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+	0.3765332	0.62346673
ENST00000569276	ENST00000302536	TMEM170A	chr16	75498366	-	VAT1L	chr16	78005747	+	0.54035604	0.45964396

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Fusion Genomic Features for TMEM170A-VAT1L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMEM170A	chr16	75498365	-	VAT1L	chr16	78005746	+	7.43E-13	1
TMEM170A	chr16	75498365	-	VAT1L	chr16	78005746	+	7.43E-13	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM170A-VAT1L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:75498366/chr16:78005747)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000357613

107_116

122.0

Topological domain

Lumenal

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000357613

138_144

122.0

Topological domain

Cytoplasmic

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000357613

1_50

122.0

Topological domain

Lumenal

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000357613

72_85

122.0

Topological domain

Cytoplasmic

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000561878

107_116

145.0

Topological domain

Lumenal

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000561878

138_144

145.0

Topological domain

Cytoplasmic

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000561878

1_50

145.0

Topological domain

Lumenal

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000561878

72_85

145.0

Topological domain

Cytoplasmic

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000357613

117_137

122.0

Transmembrane

Helical

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000357613

51_71

122.0

Transmembrane

Helical

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000357613

86_106

122.0

Transmembrane

Helical

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000561878

117_137

145.0

Transmembrane

Helical

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000561878

51_71

145.0

Transmembrane

Helical

Hgene

TMEM170A

chr16:75498366

chr16:78005747

ENST00000561878

86_106

145.0

Transmembrane

Helical

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Fusion Gene Sequence for TMEM170A-VAT1L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91781_91781_1_TMEM170A-VAT1L_TMEM170A_chr16_75498366_ENST00000357613_VAT1L_chr16_78005747_ENST00000302536_length(transcript)=2817nt_BP=222nt
GACGCTGAGGCGGCGAGGGTGAGTCGGCGCCGGCCGCTACCGCACTTCGGGCGCTCGTCCCTCATTTCTCTGTGGTGAATGGCGACGGGA
TGGAGCGCGAGGGGAGCGGCGGCAGCGGCGGGTCGGCCGGGCTCCTGCAGCAGATCCTGAGCCTGAAGGTTGTGCCGCGGGTGGGCAACG
GGACCCTGTGCCCCAACTCTACTTCCCTCTGCTCCTTCCCAGGTGAAGGAGGCCATGCAGCGGATTCACGACCGAGGGAACATTGGCAAG
TTAATTCTGGATGTAGAAAAGACCCCAACTCCACTGATGGCCAATGACAGCACAGAGACCAGTGAAGCAGGGGAAGAGGAGGAGGACCAC
GAGGGAGACAGCGAGAACAAGGAGCGGATGCCCTTTATCCAGTAACTGAGGACCCAGGTGGGAGAATGTGAAGGATGGTTTGGAAGATGA
GGACCCGGCTGAGAAAACTCTTCTGTGCCCCAGTGAACAAATGCTGTAGTCCAGTGCGTGTCGTGTTTGTCTGCAGTCAGCTGAGCTAAA
AAGCTGTTGATCACTGTTGTTTTTTGAAGTGCCAATCCCATGCCATGCAGTATTATGTCCCTCTCCTATCTGTGTATTACACATTCCCCT
CTCCCCTGTATCAAAACCATCCATCTGTGGGTTCTTCTTGACAGTTCTAGAACAGCCTTGCAAATTAATACAAGTCCCAGGCCCAATGCC
TAAGAGACCAGACGTGGGCAAAGACAAGTTTGGATGGAAAGGTGTTATCACAGAGCCCTGTCCAGCTCCTAGAATTCCTCAGGCCAGTGA
CACTTTTTTGCTGCTGGCCACCCATGCCTCTGATGAGAACACTTGCCAATTTGGCCAGCAGAAAGAGAGTAGGCCGGATGTTTTCATGAG
CCCACAAATTTAGAAACTCTCCTAGTAGTACTTTTTCTCTCTCCATTTAAGAGACAACTACGGTCAAAAGTTTGAGCCATTCTCTTCTAC
CCCTTCAGTGTCTGACCCTTTCACTGGCTCTTATCTGTAAACACAGGGAGGCAGGTATGGATTTTTCACAGTAGACAATGGGTCAACAGC
ATGAGTTTGAGGACCTGCTGTGAAGATTTCTCCTCCAAAATACATCTCATGGGCAGGATTCTTCCTGCTCCATATCTGTTTCAATTTTAA
GAAAGCACCACATACAAGACACATTCAGAAGTCATTCCTGAGCATTGCTGGTGTTTGCACACTTGCCACCTGCATTACCAATTCTGTAAA
TTTCAATTCCTGGTGGAAAGTGACCACTTTGACCATGGATTTCCCAAAGAAGAGTTCCTTTGCAGACCATAGGTGGAAAAGTCAATGAGC
ATCTCCTTCCTTGCCAAAGCATGTCCCAACATGTAACAAACTCTAGGGATACAAAAGGTTTATATTCAGCATCTGATGTCAGATGTACAG
TTCCTCCCCTCCCATATATAAACCCCGGTGTAGAATCTGCAGCGCCCTGCTCTTCGGAAACCAAGGAACAAGCCACCTGCTCACACACCT
TGTTCAACTTTTCAGCTCCTAAGGAACCCCACCCCCATGCAATTTGACTGTGCTTGAGAGGTGAATACAGTTACCTTCGAGAAACAGAGG
GAGCTCCTCACCCCGTCCTTCCAGTCCTTTTGGCTAAAATGCTTAACTATCACTCACAAACAAATGTGGAGATACCAGGAGCTCATTTGA
TTCATACCCCAACTTTGTGTTCTGAAAAACATCAGAGGGATTTTACATTGCCCAGTTTCTCCACCAACAAGCCTTAGGGTGGACCCAACC
CTTTCCGCAAGTGGTAGGAACGAATGCATCTTAGCAATTACCTGATTTCCAAAGTCCTTTTGTAGCAAATGTCACCTCATTCGTGGTCTT
TTTACCTATCCTAAGCTTATGATGATGAGTTATGTATGCCAAATACTTATCTGAAGAGTTTCTCCTCATTGTGAATGTGTATGTAAAATA
TGAAGACAAGAAAGGGTGCTTTCATCTGAGGAACCAAGGGGTGAGAGTATCCCAAAGGAGGACACCAGCATCATCTTTTCTTCGTACTCC
AGGACCCACCAATATTCCAGTTCTGGGTCATTTAGAGAGATAATGGGGCGTTTATTCCCCTATTACCTTTGCTAAGTGCTATATTATTGG
CTGTTTCTCCCGTAACCATGCTGAAAAGGGGGTCTTAGGGAGAACTGTCATCCAAGTGGCATTCCTAGTAAGTTGGGTAGAAATGACATT
TTCCAGAGCTGAAGGAGTGAAGAGCCCTTGGCCATACTAGGGCTCTCCTTCCCCCGGGGAGTGGGAACTCAGCCACATTCAGAATTCACA
TCGCCTTTGTTATGTCCAGAGGAGAGGCATAAAAAGGCACTCTCCCCCACCACCCCTACCAAATCTGGGTTTGGTTTGGTTTTATTTAAC
TAGCAAAGTTAATCCAGTAATCGCAAATTACTCCAGATGGTTAAAGAAAACCCTTTCAGAATACAGAACGAGAAAACTAGAGTTTGACCA
ATAAGACCAATTTCTGCCATGAAGAACCGGGGGACGCAAGTTAATTGTTTAACGTACTCTCATTTTAAGCACCTTCTTTCCTGTCTCTTG
ATTGTTTTTTCTGAAGGAAGTGTAAAGAATGTCTCAGTCTGCCTTAAAGGAACTGTGAAGGCTTCTCTGTAATTTAAGCTTGATAGAAGT
GAACTGAAACATTGTCTAATGTCTTTGTGGCTTTAGAGCTTTTGTTATATTGTGCCTATAAAGCAAATTATGTTTACATAAAAATATAAA

>91781_91781_1_TMEM170A-VAT1L_TMEM170A_chr16_75498366_ENST00000357613_VAT1L_chr16_78005747_ENST00000302536_length(amino acids)=158AA_BP=
MSLPTSGLLGIGPGTCINLQGCSRTVKKNPQMDGFDTGERGMCNTQIGEGHNTAWHGIGTSKNNSDQQLFSSADCRQTRHALDYSICSLG

--------------------------------------------------------------
>91781_91781_2_TMEM170A-VAT1L_TMEM170A_chr16_75498366_ENST00000561878_VAT1L_chr16_78005747_ENST00000302536_length(transcript)=2826nt_BP=231nt
GCTGGAGGTGACGCTGAGGCGGCGAGGGTGAGTCGGCGCCGGCCGCTACCGCACTTCGGGCGCTCGTCCCTCATTTCTCTGTGGTGAATG
GCGACGGGATGGAGCGCGAGGGGAGCGGCGGCAGCGGCGGGTCGGCCGGGCTCCTGCAGCAGATCCTGAGCCTGAAGGTTGTGCCGCGGG
TGGGCAACGGGACCCTGTGCCCCAACTCTACTTCCCTCTGCTCCTTCCCAGGTGAAGGAGGCCATGCAGCGGATTCACGACCGAGGGAAC
ATTGGCAAGTTAATTCTGGATGTAGAAAAGACCCCAACTCCACTGATGGCCAATGACAGCACAGAGACCAGTGAAGCAGGGGAAGAGGAG
GAGGACCACGAGGGAGACAGCGAGAACAAGGAGCGGATGCCCTTTATCCAGTAACTGAGGACCCAGGTGGGAGAATGTGAAGGATGGTTT
GGAAGATGAGGACCCGGCTGAGAAAACTCTTCTGTGCCCCAGTGAACAAATGCTGTAGTCCAGTGCGTGTCGTGTTTGTCTGCAGTCAGC
TGAGCTAAAAAGCTGTTGATCACTGTTGTTTTTTGAAGTGCCAATCCCATGCCATGCAGTATTATGTCCCTCTCCTATCTGTGTATTACA
CATTCCCCTCTCCCCTGTATCAAAACCATCCATCTGTGGGTTCTTCTTGACAGTTCTAGAACAGCCTTGCAAATTAATACAAGTCCCAGG
CCCAATGCCTAAGAGACCAGACGTGGGCAAAGACAAGTTTGGATGGAAAGGTGTTATCACAGAGCCCTGTCCAGCTCCTAGAATTCCTCA
GGCCAGTGACACTTTTTTGCTGCTGGCCACCCATGCCTCTGATGAGAACACTTGCCAATTTGGCCAGCAGAAAGAGAGTAGGCCGGATGT
TTTCATGAGCCCACAAATTTAGAAACTCTCCTAGTAGTACTTTTTCTCTCTCCATTTAAGAGACAACTACGGTCAAAAGTTTGAGCCATT
CTCTTCTACCCCTTCAGTGTCTGACCCTTTCACTGGCTCTTATCTGTAAACACAGGGAGGCAGGTATGGATTTTTCACAGTAGACAATGG
GTCAACAGCATGAGTTTGAGGACCTGCTGTGAAGATTTCTCCTCCAAAATACATCTCATGGGCAGGATTCTTCCTGCTCCATATCTGTTT
CAATTTTAAGAAAGCACCACATACAAGACACATTCAGAAGTCATTCCTGAGCATTGCTGGTGTTTGCACACTTGCCACCTGCATTACCAA
TTCTGTAAATTTCAATTCCTGGTGGAAAGTGACCACTTTGACCATGGATTTCCCAAAGAAGAGTTCCTTTGCAGACCATAGGTGGAAAAG
TCAATGAGCATCTCCTTCCTTGCCAAAGCATGTCCCAACATGTAACAAACTCTAGGGATACAAAAGGTTTATATTCAGCATCTGATGTCA
GATGTACAGTTCCTCCCCTCCCATATATAAACCCCGGTGTAGAATCTGCAGCGCCCTGCTCTTCGGAAACCAAGGAACAAGCCACCTGCT
CACACACCTTGTTCAACTTTTCAGCTCCTAAGGAACCCCACCCCCATGCAATTTGACTGTGCTTGAGAGGTGAATACAGTTACCTTCGAG
AAACAGAGGGAGCTCCTCACCCCGTCCTTCCAGTCCTTTTGGCTAAAATGCTTAACTATCACTCACAAACAAATGTGGAGATACCAGGAG
CTCATTTGATTCATACCCCAACTTTGTGTTCTGAAAAACATCAGAGGGATTTTACATTGCCCAGTTTCTCCACCAACAAGCCTTAGGGTG
GACCCAACCCTTTCCGCAAGTGGTAGGAACGAATGCATCTTAGCAATTACCTGATTTCCAAAGTCCTTTTGTAGCAAATGTCACCTCATT
CGTGGTCTTTTTACCTATCCTAAGCTTATGATGATGAGTTATGTATGCCAAATACTTATCTGAAGAGTTTCTCCTCATTGTGAATGTGTA
TGTAAAATATGAAGACAAGAAAGGGTGCTTTCATCTGAGGAACCAAGGGGTGAGAGTATCCCAAAGGAGGACACCAGCATCATCTTTTCT
TCGTACTCCAGGACCCACCAATATTCCAGTTCTGGGTCATTTAGAGAGATAATGGGGCGTTTATTCCCCTATTACCTTTGCTAAGTGCTA
TATTATTGGCTGTTTCTCCCGTAACCATGCTGAAAAGGGGGTCTTAGGGAGAACTGTCATCCAAGTGGCATTCCTAGTAAGTTGGGTAGA
AATGACATTTTCCAGAGCTGAAGGAGTGAAGAGCCCTTGGCCATACTAGGGCTCTCCTTCCCCCGGGGAGTGGGAACTCAGCCACATTCA
GAATTCACATCGCCTTTGTTATGTCCAGAGGAGAGGCATAAAAAGGCACTCTCCCCCACCACCCCTACCAAATCTGGGTTTGGTTTGGTT
TTATTTAACTAGCAAAGTTAATCCAGTAATCGCAAATTACTCCAGATGGTTAAAGAAAACCCTTTCAGAATACAGAACGAGAAAACTAGA
GTTTGACCAATAAGACCAATTTCTGCCATGAAGAACCGGGGGACGCAAGTTAATTGTTTAACGTACTCTCATTTTAAGCACCTTCTTTCC
TGTCTCTTGATTGTTTTTTCTGAAGGAAGTGTAAAGAATGTCTCAGTCTGCCTTAAAGGAACTGTGAAGGCTTCTCTGTAATTTAAGCTT
GATAGAAGTGAACTGAAACATTGTCTAATGTCTTTGTGGCTTTAGAGCTTTTGTTATATTGTGCCTATAAAGCAAATTATGTTTACATAA

>91781_91781_2_TMEM170A-VAT1L_TMEM170A_chr16_75498366_ENST00000561878_VAT1L_chr16_78005747_ENST00000302536_length(amino acids)=158AA_BP=
MSLPTSGLLGIGPGTCINLQGCSRTVKKNPQMDGFDTGERGMCNTQIGEGHNTAWHGIGTSKNNSDQQLFSSADCRQTRHALDYSICSLG

--------------------------------------------------------------
>91781_91781_3_TMEM170A-VAT1L_TMEM170A_chr16_75498366_ENST00000569276_VAT1L_chr16_78005747_ENST00000302536_length(transcript)=2800nt_BP=205nt
GGTGAGTCGGCGCCGGCCGCTACCGCACTTCGGGCGCTCGTCCCTCATTTCTCTGTGGTGAATGGCGACGGGATGGAGCGCGAGGGGAGC
GGCGGCAGCGGCGGGTCGGCCGGGCTCCTGCAGCAGATCCTGAGCCTGAAGGTTGTGCCGCGGGTGGGCAACGGGACCCTGTGCCCCAAC
TCTACTTCCCTCTGCTCCTTCCCAGGTGAAGGAGGCCATGCAGCGGATTCACGACCGAGGGAACATTGGCAAGTTAATTCTGGATGTAGA
AAAGACCCCAACTCCACTGATGGCCAATGACAGCACAGAGACCAGTGAAGCAGGGGAAGAGGAGGAGGACCACGAGGGAGACAGCGAGAA
CAAGGAGCGGATGCCCTTTATCCAGTAACTGAGGACCCAGGTGGGAGAATGTGAAGGATGGTTTGGAAGATGAGGACCCGGCTGAGAAAA
CTCTTCTGTGCCCCAGTGAACAAATGCTGTAGTCCAGTGCGTGTCGTGTTTGTCTGCAGTCAGCTGAGCTAAAAAGCTGTTGATCACTGT
TGTTTTTTGAAGTGCCAATCCCATGCCATGCAGTATTATGTCCCTCTCCTATCTGTGTATTACACATTCCCCTCTCCCCTGTATCAAAAC
CATCCATCTGTGGGTTCTTCTTGACAGTTCTAGAACAGCCTTGCAAATTAATACAAGTCCCAGGCCCAATGCCTAAGAGACCAGACGTGG
GCAAAGACAAGTTTGGATGGAAAGGTGTTATCACAGAGCCCTGTCCAGCTCCTAGAATTCCTCAGGCCAGTGACACTTTTTTGCTGCTGG
CCACCCATGCCTCTGATGAGAACACTTGCCAATTTGGCCAGCAGAAAGAGAGTAGGCCGGATGTTTTCATGAGCCCACAAATTTAGAAAC
TCTCCTAGTAGTACTTTTTCTCTCTCCATTTAAGAGACAACTACGGTCAAAAGTTTGAGCCATTCTCTTCTACCCCTTCAGTGTCTGACC
CTTTCACTGGCTCTTATCTGTAAACACAGGGAGGCAGGTATGGATTTTTCACAGTAGACAATGGGTCAACAGCATGAGTTTGAGGACCTG
CTGTGAAGATTTCTCCTCCAAAATACATCTCATGGGCAGGATTCTTCCTGCTCCATATCTGTTTCAATTTTAAGAAAGCACCACATACAA
GACACATTCAGAAGTCATTCCTGAGCATTGCTGGTGTTTGCACACTTGCCACCTGCATTACCAATTCTGTAAATTTCAATTCCTGGTGGA
AAGTGACCACTTTGACCATGGATTTCCCAAAGAAGAGTTCCTTTGCAGACCATAGGTGGAAAAGTCAATGAGCATCTCCTTCCTTGCCAA
AGCATGTCCCAACATGTAACAAACTCTAGGGATACAAAAGGTTTATATTCAGCATCTGATGTCAGATGTACAGTTCCTCCCCTCCCATAT
ATAAACCCCGGTGTAGAATCTGCAGCGCCCTGCTCTTCGGAAACCAAGGAACAAGCCACCTGCTCACACACCTTGTTCAACTTTTCAGCT
CCTAAGGAACCCCACCCCCATGCAATTTGACTGTGCTTGAGAGGTGAATACAGTTACCTTCGAGAAACAGAGGGAGCTCCTCACCCCGTC
CTTCCAGTCCTTTTGGCTAAAATGCTTAACTATCACTCACAAACAAATGTGGAGATACCAGGAGCTCATTTGATTCATACCCCAACTTTG
TGTTCTGAAAAACATCAGAGGGATTTTACATTGCCCAGTTTCTCCACCAACAAGCCTTAGGGTGGACCCAACCCTTTCCGCAAGTGGTAG
GAACGAATGCATCTTAGCAATTACCTGATTTCCAAAGTCCTTTTGTAGCAAATGTCACCTCATTCGTGGTCTTTTTACCTATCCTAAGCT
TATGATGATGAGTTATGTATGCCAAATACTTATCTGAAGAGTTTCTCCTCATTGTGAATGTGTATGTAAAATATGAAGACAAGAAAGGGT
GCTTTCATCTGAGGAACCAAGGGGTGAGAGTATCCCAAAGGAGGACACCAGCATCATCTTTTCTTCGTACTCCAGGACCCACCAATATTC
CAGTTCTGGGTCATTTAGAGAGATAATGGGGCGTTTATTCCCCTATTACCTTTGCTAAGTGCTATATTATTGGCTGTTTCTCCCGTAACC
ATGCTGAAAAGGGGGTCTTAGGGAGAACTGTCATCCAAGTGGCATTCCTAGTAAGTTGGGTAGAAATGACATTTTCCAGAGCTGAAGGAG
TGAAGAGCCCTTGGCCATACTAGGGCTCTCCTTCCCCCGGGGAGTGGGAACTCAGCCACATTCAGAATTCACATCGCCTTTGTTATGTCC
AGAGGAGAGGCATAAAAAGGCACTCTCCCCCACCACCCCTACCAAATCTGGGTTTGGTTTGGTTTTATTTAACTAGCAAAGTTAATCCAG
TAATCGCAAATTACTCCAGATGGTTAAAGAAAACCCTTTCAGAATACAGAACGAGAAAACTAGAGTTTGACCAATAAGACCAATTTCTGC
CATGAAGAACCGGGGGACGCAAGTTAATTGTTTAACGTACTCTCATTTTAAGCACCTTCTTTCCTGTCTCTTGATTGTTTTTTCTGAAGG
AAGTGTAAAGAATGTCTCAGTCTGCCTTAAAGGAACTGTGAAGGCTTCTCTGTAATTTAAGCTTGATAGAAGTGAACTGAAACATTGTCT
AATGTCTTTGTGGCTTTAGAGCTTTTGTTATATTGTGCCTATAAAGCAAATTATGTTTACATAAAAATATAAATAAAGTATTCAGCATAG

>91781_91781_3_TMEM170A-VAT1L_TMEM170A_chr16_75498366_ENST00000569276_VAT1L_chr16_78005747_ENST00000302536_length(amino acids)=158AA_BP=
MSLPTSGLLGIGPGTCINLQGCSRTVKKNPQMDGFDTGERGMCNTQIGEGHNTAWHGIGTSKNNSDQQLFSSADCRQTRHALDYSICSLG

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Fusion Gene PPI Analysis for TMEM170A-VAT1L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for TMEM170A-VAT1L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for TMEM170A-VAT1L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source