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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TMEM182-SLC9A2 (FusionGDB2 ID:91826)

Fusion Gene Summary for TMEM182-SLC9A2

check button Fusion gene summary
Fusion gene informationFusion gene name: TMEM182-SLC9A2
Fusion gene ID: 91826
HgeneTgene
Gene symbol

TMEM182

SLC9A2

Gene ID

130827

6549

Gene nametransmembrane protein 182solute carrier family 9 member A2
Synonyms-NHE2
Cytomap

2q12.1

2q12.1

Type of geneprotein-codingprotein-coding
Descriptiontransmembrane protein 182sodium/hydrogen exchanger 2Na(+)/H(+) exchanger 2solute carrier family 9 (sodium/hydrogen exchanger), member 2solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000486293, ENST00000409173, 
ENST00000409528, ENST00000412401, 
ENST00000233969, ENST00000469286, 
Fusion gene scores* DoF score6 X 4 X 6=1441 X 1 X 1=1
# samples 61
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: TMEM182 [Title/Abstract] AND SLC9A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTMEM182(103380886)-SLC9A2(103274023), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across TMEM182 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC9A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07C-01ATMEM182chr2

103380886

-SLC9A2chr2

103274023

+
ChimerDB4BRCATCGA-A8-A07C-01ATMEM182chr2

103380886

+SLC9A2chr2

103274023

+


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Fusion Gene ORF analysis for TMEM182-SLC9A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000486293ENST00000233969TMEM182chr2

103380886

+SLC9A2chr2

103274023

+
3UTR-intronENST00000486293ENST00000469286TMEM182chr2

103380886

+SLC9A2chr2

103274023

+
5CDS-intronENST00000409173ENST00000469286TMEM182chr2

103380886

+SLC9A2chr2

103274023

+
5CDS-intronENST00000409528ENST00000469286TMEM182chr2

103380886

+SLC9A2chr2

103274023

+
5CDS-intronENST00000412401ENST00000469286TMEM182chr2

103380886

+SLC9A2chr2

103274023

+
In-frameENST00000409173ENST00000233969TMEM182chr2

103380886

+SLC9A2chr2

103274023

+
In-frameENST00000409528ENST00000233969TMEM182chr2

103380886

+SLC9A2chr2

103274023

+
In-frameENST00000412401ENST00000233969TMEM182chr2

103380886

+SLC9A2chr2

103274023

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409528TMEM182chr2103380886+ENST00000233969SLC9A2chr2103274023+5284305222454810
ENST00000409173TMEM182chr2103380886+ENST00000233969SLC9A2chr2103274023+53663871852536783
ENST00000412401TMEM182chr2103380886+ENST00000233969SLC9A2chr2103274023+55155361992685828

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409528ENST00000233969TMEM182chr2103380886+SLC9A2chr2103274023+0.0008662780.99913377
ENST00000409173ENST00000233969TMEM182chr2103380886+SLC9A2chr2103274023+0.0004175350.99958247
ENST00000412401ENST00000233969TMEM182chr2103380886+SLC9A2chr2103274023+0.0003137190.99968636

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Fusion Genomic Features for TMEM182-SLC9A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TMEM182chr2103380886+SLC9A2chr2103274022+0.0011792950.9988207
TMEM182chr2103380886+SLC9A2chr2103274022+0.0011792950.9988207

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TMEM182-SLC9A2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:103380886/chr2:103274023)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012430_45096813.0IntramembraneName%3DL
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012101_10696813.0Topological domainCytoplasmic
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012128_13896813.0Topological domainExtracellular
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012160_16896813.0Topological domainCytoplasmic
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012190_20896813.0Topological domainExtracellular
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012230_23696813.0Topological domainCytoplasmic
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012258_27796813.0Topological domainExtracellular
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012299_30796813.0Topological domainCytoplasmic
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012329_36096813.0Topological domainExtracellular
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012382_39196813.0Topological domainCytoplasmic
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012413_42996813.0Topological domainExtracellular
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012451_45896813.0Topological domainExtracellular
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012480_81296813.0Topological domainCytoplasmic
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012107_12796813.0TransmembraneHelical%3B Name%3DC/M3
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012139_15996813.0TransmembraneHelical%3B Name%3DD/M4
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012169_18996813.0TransmembraneHelical%3B Name%3DE/M5
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012209_22996813.0TransmembraneHelical%3B Name%3DF/M5A
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012237_25796813.0TransmembraneHelical%3B Name%3DG/M5B
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012278_29896813.0TransmembraneHelical%3B Name%3DH/M6
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012308_32896813.0TransmembraneHelical%3B Name%3DI/M7
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012361_38196813.0TransmembraneHelical%3B Name%3DJ/M8
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012392_41296813.0TransmembraneHelical%3B Name%3DK/M9
TgeneSLC9A2chr2:103380886chr2:103274023ENST00000233969012459_47996813.0TransmembraneHelical%3B Name%3DM13

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTMEM182chr2:103380886chr2:103274023ENST00000409528+35136_15314134.0Topological domainCytoplasmic
HgeneTMEM182chr2:103380886chr2:103274023ENST00000409528+35175_20014134.0Topological domainExtracellular
HgeneTMEM182chr2:103380886chr2:103274023ENST00000409528+35222_22914134.0Topological domainCytoplasmic
HgeneTMEM182chr2:103380886chr2:103274023ENST00000409528+3527_11414134.0Topological domainExtracellular
HgeneTMEM182chr2:103380886chr2:103274023ENST00000412401+35136_153110230.0Topological domainCytoplasmic
HgeneTMEM182chr2:103380886chr2:103274023ENST00000412401+35175_200110230.0Topological domainExtracellular
HgeneTMEM182chr2:103380886chr2:103274023ENST00000412401+35222_229110230.0Topological domainCytoplasmic
HgeneTMEM182chr2:103380886chr2:103274023ENST00000412401+3527_114110230.0Topological domainExtracellular
HgeneTMEM182chr2:103380886chr2:103274023ENST00000409528+35115_13514134.0TransmembraneHelical
HgeneTMEM182chr2:103380886chr2:103274023ENST00000409528+35154_17414134.0TransmembraneHelical
HgeneTMEM182chr2:103380886chr2:103274023ENST00000409528+35201_22114134.0TransmembraneHelical
HgeneTMEM182chr2:103380886chr2:103274023ENST00000412401+35115_135110230.0TransmembraneHelical
HgeneTMEM182chr2:103380886chr2:103274023ENST00000412401+35154_174110230.0TransmembraneHelical
HgeneTMEM182chr2:103380886chr2:103274023ENST00000412401+35201_221110230.0TransmembraneHelical
TgeneSLC9A2chr2:103380886chr2:103274023ENST0000023396901214_3396813.0IntramembraneName%3DA/M1
TgeneSLC9A2chr2:103380886chr2:103274023ENST0000023396901280_10096813.0IntramembraneName%3DB/M2
TgeneSLC9A2chr2:103380886chr2:103274023ENST000002339690121_1396813.0Topological domainCytoplasmic
TgeneSLC9A2chr2:103380886chr2:103274023ENST0000023396901234_7996813.0Topological domainCytoplasmic


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Fusion Gene Sequence for TMEM182-SLC9A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>91826_91826_1_TMEM182-SLC9A2_TMEM182_chr2_103380886_ENST00000409173_SLC9A2_chr2_103274023_ENST00000233969_length(transcript)=5366nt_BP=387nt
GAGAGGGGGCGGGTGCTACCTGGCAGCTCCGCGGGTGCGTGGCCGGTGCTGGCTGGGAGTTCTGGTCTCAGGCAAGGTGGGGACTGGGCA
CATCATCAATACGGAATCATGGAAAACTAGAAGAGTTTCAAGTGACAGGCAAATGTCCAATTTTCTGAAGAAAAAAGACACCTTTTACCT
CCTCCATGATAGAGAACGTCACTTTTCACCATGAAGGGTTCTTCTGGAGGTGTTGGTTTAATGGGATTGTGGAAGAGAATGACTCCAATA
TTTGGAAGTTCTGGTACACCAATCAGCCACCGTCCAAGAACTGCACACATGCTTACCTGTCTCCGTACCCCTTCATGAGAGGCGAGCACA
ACTCGACCTCCTATGACTCTGCAGTTAGCTTCCATCTGTATCACAAGTTGCCCACAATAGTGCCTGAGAGCTGCCTTCTTATAATGGTTG
GACTTCTACTAGGTGGGATTATTTTTGGTGTTGATGAGAAGTCTCCCCCTGCAATGAAGACTGATGTATTTTTCTTGTACCTCCTCCCAC
CCATCGTGCTGGATGCCGGCTATTTCATGCCCACTCGCCCATTCTTTGAGAACATTGGCACGATTTTCTGGTATGCTGTGGTAGGGACAC
TTTGGAATTCCATTGGCATTGGGGTGTCTTTGTTTGGTATCTGCCAGATCGAAGCATTCGGCCTCAGCGACATCACTTTGCTCCAGAACC
TGCTCTTTGGCAGCTTAATCTCAGCTGTCGATCCTGTGGCTGTGCTTGCTGTCTTTGAGAACATTCACGTCAATGAGCAGCTCTACATCC
TGGTCTTTGGAGAGTCCCTGCTGAATGATGCAGTAACAGTGGTCCTGTACAACTTGTTCAAGTCGTTTTGCCAGATGAAAACCATTGAGA
CCATTGATGTGTTTGCAGGAATCGCCAACTTCTTTGTTGTGGGAATCGGTGGGGTGCTGATTGGCATCTTCTTGGGCTTTATAGCGGCAT
TTACTACTCGATTCACCCATAATATCCGAGTGATCGAGCCACTGTTTGTTTTCCTGTACAGTTATTTGTCCTACATCACAGCTGAAATGT
TTCACCTCTCAGGCATCATGGCAATCACTGCTTGTGCAATGACTATGAATAAGTACGTAGAAGAAAATGTATCTCAGAAATCCTACACGA
CCATCAAGTACTTCATGAAGATGCTGAGCAGTGTCAGCGAAACCTTGATCTTCATCTTCATGGGTGTGTCTACCGTGGGCAAGAACCACG
AGTGGAACTGGGCCTTCGTCTGCTTCACCCTGGCCTTCTGCCTCATGTGGCGAGCCCTGGGTGTTTTTGTCCTGACTCAGGTCATTAATA
GGTTCCGGACCATTCCCCTGACCTTTAAGGACCAGTTCATCATTGCCTATGGAGGACTTCGAGGTGCCATCTGTTTTGCGTTAGTGTTTC
TCCTTCCTGCTGCTGTGTTTCCTCGGAAAAAATTGTTTATTACGGCTGCCATTGTTGTCATATTCTTTACTGTCTTCATTCTGGGAATAA
CTATTCGACCACTGGTGGAGTTTCTTGATGTCAAGAGGTCCAATAAGAAACAACAAGCTGTCAGTGAAGAAATCTATTGTCGGTTGTTTG
ATCATGTGAAGACTGGAATTGAAGATGTTTGTGGACATTGGGGTCACAACTTTTGGAGAGACAAGTTTAAGAAGTTTGATGATAAATATC
TGCGGAAGCTTTTGATTCGGGAAAACCAACCAAAGTCAAGTATTGTATCTTTATATAAAAAGCTTGAAATAAAACATGCCATTGAGATGG
CAGAGACTGGGATGATAAGTACTGTCCCTACATTTGCATCTCTAAATGATTGTCGTGAAGAAAAAATAAGGAAGGTCACGTCCAGTGAAA
CTGATGAAATTCGAGAACTCTTATCAAGAAATCTCTATCAAATCCGTCAGCGAACTTTATCCTACAACAGACACAGTCTGACAGCCGACA
CAAGTGAGAGACAAGCCAAGGAGATTCTGATTCGCCGGCGACACAGTTTGCGAGAAAGCATTAGGAAGGACAGCAGCTTGAATCGAGAAC
ACAGGGCTTCCACTTCAACCTCCCGATATTTATCCTTACCTAAAAATACGAAGCTTCCAGAAAAGCTACAAAAGAGGAGGACTATTTCTA
TTGCAGATGGCAATAGCAGCGACTCAGACGCAGATGCCGGGACCACCGTGCTCAATTTGCAGCCCAGAGCCAGGCGCTTCTTGCCAGAAC
AGTTCTCCAAGAAATCCCCCCAGTCCTATAAAATGGAATGGAAGAATGAGGTAGATGTTGATTCTGGCCGAGATATGCCCAGCACCCCCC
CAACACCCCACAGCAGAGAAAAGGGCACCCAGACGTCAGGCTTACTACAGCAGCCCCTTCTCTCTAAAGACCAGTCTGGCTCAGAGAGGG
AAGACAGTTTGACTGAAGGCATCCCGCCCAAGCCGCCACCACGGCTGGTCTGGAGGGCATCGGAACCTGGAAGCCGGAAAGCCCGATTTG
GGAGTGAGAAGCCTTAAGAGAAGCAGCGAAAGCAGATCTGAGTGTCTGACCCAGGACAGCTGTGGTTTGTCACTCTGAAACCTGATGCAA
CAGTGGAATCCATGTAAAACTCTCTGTGCATCTAAATACTTCTGGAGGGCGACAGATTCATGCCACGGATAAATGAGGCAAATCCGAAGA
AAAGGAAAATCGAATAAAAAATAGTCCCACAAAATACCTTTTGTGACTAATGGGTAGCAATCGTATTATTTGCTGGCCTGAAGAGAAAAA
ATGGTAATGTGTGCCTTTATTGAACTTGAATGACAGAACTTGAAATTTTTAACACATCCTTCTTGGTGAAGATTTTAATATATTACTTAT
ATGCTTCAAATTTTATTTATGAAAAAATATGTATATCTGTAATCAGTTGTTAAGTGAATGGCACTAAAAGTATCGAGAACAGCTTTCTTT
CCCAGGGGTGAAGGATGGCGCTCGGGGGTGACTCCTAAGCTCAGCGTGGAAGCTTTTCCCTGTCCTGACCCGATGGAGCAGCCGGTAAGT
GAAGAGCACAGCTGGAAGCAGAGACACCTTATGACTCAAACTGGGCAAACAATCGGAACGTCATGCAGAAGGAATGGCCTGACTCCTGCA
GTGCAGATTGGAGGCCCCAGAACTCCTATGAACTACTGAGAGTCTACTGGTTTTTAACTTGTTCCTCTGTCTACTGTGTGTTTGGGGGTG
ACATCTAAATTCCATTTCTTCTTCTTGTTTAAATGGTGCAGAGAGAAAGGTTGCCCAGACATCCACCAGCTTACTGTGTTGACAGATTTG
GGAGCAGCTTTTGATGAAGTTCCACCCATGAGGGTCCATGTGGCAAGTAGGGCCACAGGGCAGCACCTGGTTACAACTTGCTGGTGGGTT
TTATGTTGTGCAATACTAGGAGGAGGAGGCAGGTGATCTATGCTGATCTATGATCACCTGCTTCAGTAGAATTTTTCTGTAGAGTGTTGT
TTGAATTTTGAGCCTCCAGGTTAGAGGCTCCAAGCAGACAAAGAAGAAAGTTTGTAGACACAATATTCTAACATTGCACAAGTTGATGAG
ATATCAAGTTTTGAATATTATTCAGGAAGCACTTTGGAGAATGTGGGAGTCCTACTGTTTTGCACTAGTCTGTAATTTGTTACCTCTCCC
CATTCGATAATATAGTAACTCAGAATTTTCATATAAAATTGAATTCTACTCATTAGAGTACTTTTTAAAAGTACAGCAGAAAGAAAAGAA
GTGGAACATAAGCATTCAAGATTAATATTTGATTCTCTATCTCTTAACTGTAGATTTTATTGGCCTGTTTTTTTTTTCTAAATAATTCTT
TAAAACTTGACTGGAACATGCCTCTGCATTTCTGAGTGTAGAAATTAAATGAAGCCACTCACAGTCCTTTGATTTCCCACTGAAGATACC
CCAAAGGATGCAAGTGCCTACAGTATTATCAGGAGGAGAACATGAAAATATTAAGACAAAAATCCTCAGCAGTTGTTCTCCACCCCTTCT
CCACCTCCACCAGCAAGGAGAAGTCAATCTACACTTTTTTCTCATGTTCTAAAGTCTTAGAATACTGCTGGATTGTTGAGCATGAGACAG
AGCAAAGGTTAGATACACAAGGTACAAGTTCATAGGAGCACAATTCCTTGATTCAGGGAAAGTAGCACAGAATGCAATTTGAAAACTACA
GGCTTAGGACTCTGTGCCAAAAATCTCTATTTTAAATGAAAATATTTATATAAAAATACATTTATTCTGCTTAACACAAATTAAAACTGA
CATAAAATTTTATGATAATAACATGATTCAAGAAATGTGATGTAGATTTTTGAGAATGCCAAAAATCAGGTTTCAGAAAAGCTACAGTAT
GAAATCTGAAAAGCAACAGAAATTGAAAGTGACCTTAAAGAATAAATTTCCTAATTTTTCCCAGTTTCCTATGTTTATAACTATTATAAA
GAGTTTAACTTTCTGGAACTGAAGGAGAAAACATGAAAATGTTTATATTGCTTCTTGTTAAGCAGGTAGACCAAATTCCGCTTTCAGTAA
TTCATCCATACAGAATTTGGATGACTATGTATAAAGGAAAACTTAAATCTTAATTATTATCAGTTTAAATTTTTTTTGTTTGTTGAATGA
CAAAGGCAATAAAAATAAATTTGACTTTAGCTTTTTTTCTATACTTTCCTCTTTTTGTAATTCTTAAATTCTAGTCACTAGTCATTATGA
GAGTATTGACTAAATATTTTCACAATCTAAATATTGTCACAATCTAAATTTCTGTAGTAGAGAGAGCCGTAGCCCTTTGTAAAGGCTTTC
GTTCGTCCAAACAACACTTGATCCAACCAAAGTTCCAATGTGACTGTGGATCTTTGATAGGTCTTTGGTGTTGGTTGTAACAAAATTTGA
TTTGAACTACCTATAAATGAAAAGTCGGGGTTTATTACTTTATATGTAATGCTGAGAGGAGACTGTTGGGAACAGTTATGTCAATGAGCA
AACTAGAAATTGGCTTCAAAGTCTAATACTTTTAAAAGCATGTGTTTTGTGTATATGCTCACAAAATGTCTGTGAAGAGATTTCTTTCAG
CTTTTGCTCAGCTTTATGGTGGGGTGTACTGTTTTATCTGGGCGGTGAGGGTATTGATTTACATAAAAACTGTAGACAAACACAGTACGA
GTCTCAGCACGTTTTGCATTTATTGTACTGCCCAAATTGTTTTTATGTTAAAAGTCACGTTTCATAATCTGCAATATTTTTGTCAAAGTG

>91826_91826_1_TMEM182-SLC9A2_TMEM182_chr2_103380886_ENST00000409173_SLC9A2_chr2_103274023_ENST00000233969_length(amino acids)=783AA_BP=68
MIENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSKNCTHAYLSPYPFMRGEHNSTSYDSAVSFHLYHKLPTIVPESCLLIMVGL
LLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLL
FGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFT
TRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEW
NWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITI
RPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAE
TGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHR
ASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPT

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>91826_91826_2_TMEM182-SLC9A2_TMEM182_chr2_103380886_ENST00000409528_SLC9A2_chr2_103274023_ENST00000233969_length(transcript)=5284nt_BP=305nt
AGAGAGAGGGGGCGGGTGCTACCTGGCAGCTCCGCGGGTGCGTGGCCGGTGCTGGCTGGGAGTTCTGGTCTCAGGCAAGGTGGGGACTGG
GCACATCATCAATACGATAGAGAACGTCACTTTTCACCATGAAGGGTTCTTCTGGAGGTGTTGGTTTAATGGGATTGTGGAAGAGAATGA
CTCCAATATTTGGAAGTTCTGGTACACCAATCAGCCACCGTCCAAGAACTGCACACATGCTTACCTGTCTCCGTACCCCTTCATGAGAGG
CGAGCACAACTCGACCTCCTATGACTCTGCAGTTAGCTTCCATCTGTATCACAAGTTGCCCACAATAGTGCCTGAGAGCTGCCTTCTTAT
AATGGTTGGACTTCTACTAGGTGGGATTATTTTTGGTGTTGATGAGAAGTCTCCCCCTGCAATGAAGACTGATGTATTTTTCTTGTACCT
CCTCCCACCCATCGTGCTGGATGCCGGCTATTTCATGCCCACTCGCCCATTCTTTGAGAACATTGGCACGATTTTCTGGTATGCTGTGGT
AGGGACACTTTGGAATTCCATTGGCATTGGGGTGTCTTTGTTTGGTATCTGCCAGATCGAAGCATTCGGCCTCAGCGACATCACTTTGCT
CCAGAACCTGCTCTTTGGCAGCTTAATCTCAGCTGTCGATCCTGTGGCTGTGCTTGCTGTCTTTGAGAACATTCACGTCAATGAGCAGCT
CTACATCCTGGTCTTTGGAGAGTCCCTGCTGAATGATGCAGTAACAGTGGTCCTGTACAACTTGTTCAAGTCGTTTTGCCAGATGAAAAC
CATTGAGACCATTGATGTGTTTGCAGGAATCGCCAACTTCTTTGTTGTGGGAATCGGTGGGGTGCTGATTGGCATCTTCTTGGGCTTTAT
AGCGGCATTTACTACTCGATTCACCCATAATATCCGAGTGATCGAGCCACTGTTTGTTTTCCTGTACAGTTATTTGTCCTACATCACAGC
TGAAATGTTTCACCTCTCAGGCATCATGGCAATCACTGCTTGTGCAATGACTATGAATAAGTACGTAGAAGAAAATGTATCTCAGAAATC
CTACACGACCATCAAGTACTTCATGAAGATGCTGAGCAGTGTCAGCGAAACCTTGATCTTCATCTTCATGGGTGTGTCTACCGTGGGCAA
GAACCACGAGTGGAACTGGGCCTTCGTCTGCTTCACCCTGGCCTTCTGCCTCATGTGGCGAGCCCTGGGTGTTTTTGTCCTGACTCAGGT
CATTAATAGGTTCCGGACCATTCCCCTGACCTTTAAGGACCAGTTCATCATTGCCTATGGAGGACTTCGAGGTGCCATCTGTTTTGCGTT
AGTGTTTCTCCTTCCTGCTGCTGTGTTTCCTCGGAAAAAATTGTTTATTACGGCTGCCATTGTTGTCATATTCTTTACTGTCTTCATTCT
GGGAATAACTATTCGACCACTGGTGGAGTTTCTTGATGTCAAGAGGTCCAATAAGAAACAACAAGCTGTCAGTGAAGAAATCTATTGTCG
GTTGTTTGATCATGTGAAGACTGGAATTGAAGATGTTTGTGGACATTGGGGTCACAACTTTTGGAGAGACAAGTTTAAGAAGTTTGATGA
TAAATATCTGCGGAAGCTTTTGATTCGGGAAAACCAACCAAAGTCAAGTATTGTATCTTTATATAAAAAGCTTGAAATAAAACATGCCAT
TGAGATGGCAGAGACTGGGATGATAAGTACTGTCCCTACATTTGCATCTCTAAATGATTGTCGTGAAGAAAAAATAAGGAAGGTCACGTC
CAGTGAAACTGATGAAATTCGAGAACTCTTATCAAGAAATCTCTATCAAATCCGTCAGCGAACTTTATCCTACAACAGACACAGTCTGAC
AGCCGACACAAGTGAGAGACAAGCCAAGGAGATTCTGATTCGCCGGCGACACAGTTTGCGAGAAAGCATTAGGAAGGACAGCAGCTTGAA
TCGAGAACACAGGGCTTCCACTTCAACCTCCCGATATTTATCCTTACCTAAAAATACGAAGCTTCCAGAAAAGCTACAAAAGAGGAGGAC
TATTTCTATTGCAGATGGCAATAGCAGCGACTCAGACGCAGATGCCGGGACCACCGTGCTCAATTTGCAGCCCAGAGCCAGGCGCTTCTT
GCCAGAACAGTTCTCCAAGAAATCCCCCCAGTCCTATAAAATGGAATGGAAGAATGAGGTAGATGTTGATTCTGGCCGAGATATGCCCAG
CACCCCCCCAACACCCCACAGCAGAGAAAAGGGCACCCAGACGTCAGGCTTACTACAGCAGCCCCTTCTCTCTAAAGACCAGTCTGGCTC
AGAGAGGGAAGACAGTTTGACTGAAGGCATCCCGCCCAAGCCGCCACCACGGCTGGTCTGGAGGGCATCGGAACCTGGAAGCCGGAAAGC
CCGATTTGGGAGTGAGAAGCCTTAAGAGAAGCAGCGAAAGCAGATCTGAGTGTCTGACCCAGGACAGCTGTGGTTTGTCACTCTGAAACC
TGATGCAACAGTGGAATCCATGTAAAACTCTCTGTGCATCTAAATACTTCTGGAGGGCGACAGATTCATGCCACGGATAAATGAGGCAAA
TCCGAAGAAAAGGAAAATCGAATAAAAAATAGTCCCACAAAATACCTTTTGTGACTAATGGGTAGCAATCGTATTATTTGCTGGCCTGAA
GAGAAAAAATGGTAATGTGTGCCTTTATTGAACTTGAATGACAGAACTTGAAATTTTTAACACATCCTTCTTGGTGAAGATTTTAATATA
TTACTTATATGCTTCAAATTTTATTTATGAAAAAATATGTATATCTGTAATCAGTTGTTAAGTGAATGGCACTAAAAGTATCGAGAACAG
CTTTCTTTCCCAGGGGTGAAGGATGGCGCTCGGGGGTGACTCCTAAGCTCAGCGTGGAAGCTTTTCCCTGTCCTGACCCGATGGAGCAGC
CGGTAAGTGAAGAGCACAGCTGGAAGCAGAGACACCTTATGACTCAAACTGGGCAAACAATCGGAACGTCATGCAGAAGGAATGGCCTGA
CTCCTGCAGTGCAGATTGGAGGCCCCAGAACTCCTATGAACTACTGAGAGTCTACTGGTTTTTAACTTGTTCCTCTGTCTACTGTGTGTT
TGGGGGTGACATCTAAATTCCATTTCTTCTTCTTGTTTAAATGGTGCAGAGAGAAAGGTTGCCCAGACATCCACCAGCTTACTGTGTTGA
CAGATTTGGGAGCAGCTTTTGATGAAGTTCCACCCATGAGGGTCCATGTGGCAAGTAGGGCCACAGGGCAGCACCTGGTTACAACTTGCT
GGTGGGTTTTATGTTGTGCAATACTAGGAGGAGGAGGCAGGTGATCTATGCTGATCTATGATCACCTGCTTCAGTAGAATTTTTCTGTAG
AGTGTTGTTTGAATTTTGAGCCTCCAGGTTAGAGGCTCCAAGCAGACAAAGAAGAAAGTTTGTAGACACAATATTCTAACATTGCACAAG
TTGATGAGATATCAAGTTTTGAATATTATTCAGGAAGCACTTTGGAGAATGTGGGAGTCCTACTGTTTTGCACTAGTCTGTAATTTGTTA
CCTCTCCCCATTCGATAATATAGTAACTCAGAATTTTCATATAAAATTGAATTCTACTCATTAGAGTACTTTTTAAAAGTACAGCAGAAA
GAAAAGAAGTGGAACATAAGCATTCAAGATTAATATTTGATTCTCTATCTCTTAACTGTAGATTTTATTGGCCTGTTTTTTTTTTCTAAA
TAATTCTTTAAAACTTGACTGGAACATGCCTCTGCATTTCTGAGTGTAGAAATTAAATGAAGCCACTCACAGTCCTTTGATTTCCCACTG
AAGATACCCCAAAGGATGCAAGTGCCTACAGTATTATCAGGAGGAGAACATGAAAATATTAAGACAAAAATCCTCAGCAGTTGTTCTCCA
CCCCTTCTCCACCTCCACCAGCAAGGAGAAGTCAATCTACACTTTTTTCTCATGTTCTAAAGTCTTAGAATACTGCTGGATTGTTGAGCA
TGAGACAGAGCAAAGGTTAGATACACAAGGTACAAGTTCATAGGAGCACAATTCCTTGATTCAGGGAAAGTAGCACAGAATGCAATTTGA
AAACTACAGGCTTAGGACTCTGTGCCAAAAATCTCTATTTTAAATGAAAATATTTATATAAAAATACATTTATTCTGCTTAACACAAATT
AAAACTGACATAAAATTTTATGATAATAACATGATTCAAGAAATGTGATGTAGATTTTTGAGAATGCCAAAAATCAGGTTTCAGAAAAGC
TACAGTATGAAATCTGAAAAGCAACAGAAATTGAAAGTGACCTTAAAGAATAAATTTCCTAATTTTTCCCAGTTTCCTATGTTTATAACT
ATTATAAAGAGTTTAACTTTCTGGAACTGAAGGAGAAAACATGAAAATGTTTATATTGCTTCTTGTTAAGCAGGTAGACCAAATTCCGCT
TTCAGTAATTCATCCATACAGAATTTGGATGACTATGTATAAAGGAAAACTTAAATCTTAATTATTATCAGTTTAAATTTTTTTTGTTTG
TTGAATGACAAAGGCAATAAAAATAAATTTGACTTTAGCTTTTTTTCTATACTTTCCTCTTTTTGTAATTCTTAAATTCTAGTCACTAGT
CATTATGAGAGTATTGACTAAATATTTTCACAATCTAAATATTGTCACAATCTAAATTTCTGTAGTAGAGAGAGCCGTAGCCCTTTGTAA
AGGCTTTCGTTCGTCCAAACAACACTTGATCCAACCAAAGTTCCAATGTGACTGTGGATCTTTGATAGGTCTTTGGTGTTGGTTGTAACA
AAATTTGATTTGAACTACCTATAAATGAAAAGTCGGGGTTTATTACTTTATATGTAATGCTGAGAGGAGACTGTTGGGAACAGTTATGTC
AATGAGCAAACTAGAAATTGGCTTCAAAGTCTAATACTTTTAAAAGCATGTGTTTTGTGTATATGCTCACAAAATGTCTGTGAAGAGATT
TCTTTCAGCTTTTGCTCAGCTTTATGGTGGGGTGTACTGTTTTATCTGGGCGGTGAGGGTATTGATTTACATAAAAACTGTAGACAAACA
CAGTACGAGTCTCAGCACGTTTTGCATTTATTGTACTGCCCAAATTGTTTTTATGTTAAAAGTCACGTTTCATAATCTGCAATATTTTTG

>91826_91826_2_TMEM182-SLC9A2_TMEM182_chr2_103380886_ENST00000409528_SLC9A2_chr2_103274023_ENST00000233969_length(amino acids)=810AA_BP=95
MAAPRVRGRCWLGVLVSGKVGTGHIINTIENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSKNCTHAYLSPYPFMRGEHNSTSY
DSAVSFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSI
GIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVF
AGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYF
MKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAA
VFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLL
IRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQ
AKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKK
SPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP

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>91826_91826_3_TMEM182-SLC9A2_TMEM182_chr2_103380886_ENST00000412401_SLC9A2_chr2_103274023_ENST00000233969_length(transcript)=5515nt_BP=536nt
GGCGAGCAAAGGGAATATGAATCTGCCGGTGGGGCGTGAGCGAGAAGCCACCAAAACATGAGCTAGGACAGCCTTCTCAAGAAGATTCTG
CCAACTCAAAAATATTATTCTTTTTTTTTTTTTTTTGCTGTTGTTTCTGAGAAACTAGGTGTCTTACCATTTTAAAATTTCATATTTTAT
TTAAAAGGAAACCAGTGAATTGAAAATGAGACTAAATATCGCTATCTTCTTTGGAGCTCTCTTTGGTGCTTTGGGGGTGTTACTCTTTTT
GGTGGCTTTTGGATCGGATTATTGGCTTCTTGCAACTGAAGTGGGGAGATGTTCAGGTGAAAAGAATATAGAGAACGTCACTTTTCACCA
TGAAGGGTTCTTCTGGAGGTGTTGGTTTAATGGGATTGTGGAAGAGAATGACTCCAATATTTGGAAGTTCTGGTACACCAATCAGCCACC
GTCCAAGAACTGCACACATGCTTACCTGTCTCCGTACCCCTTCATGAGAGGCGAGCACAACTCGACCTCCTATGACTCTGCAGTTAGCTT
CCATCTGTATCACAAGTTGCCCACAATAGTGCCTGAGAGCTGCCTTCTTATAATGGTTGGACTTCTACTAGGTGGGATTATTTTTGGTGT
TGATGAGAAGTCTCCCCCTGCAATGAAGACTGATGTATTTTTCTTGTACCTCCTCCCACCCATCGTGCTGGATGCCGGCTATTTCATGCC
CACTCGCCCATTCTTTGAGAACATTGGCACGATTTTCTGGTATGCTGTGGTAGGGACACTTTGGAATTCCATTGGCATTGGGGTGTCTTT
GTTTGGTATCTGCCAGATCGAAGCATTCGGCCTCAGCGACATCACTTTGCTCCAGAACCTGCTCTTTGGCAGCTTAATCTCAGCTGTCGA
TCCTGTGGCTGTGCTTGCTGTCTTTGAGAACATTCACGTCAATGAGCAGCTCTACATCCTGGTCTTTGGAGAGTCCCTGCTGAATGATGC
AGTAACAGTGGTCCTGTACAACTTGTTCAAGTCGTTTTGCCAGATGAAAACCATTGAGACCATTGATGTGTTTGCAGGAATCGCCAACTT
CTTTGTTGTGGGAATCGGTGGGGTGCTGATTGGCATCTTCTTGGGCTTTATAGCGGCATTTACTACTCGATTCACCCATAATATCCGAGT
GATCGAGCCACTGTTTGTTTTCCTGTACAGTTATTTGTCCTACATCACAGCTGAAATGTTTCACCTCTCAGGCATCATGGCAATCACTGC
TTGTGCAATGACTATGAATAAGTACGTAGAAGAAAATGTATCTCAGAAATCCTACACGACCATCAAGTACTTCATGAAGATGCTGAGCAG
TGTCAGCGAAACCTTGATCTTCATCTTCATGGGTGTGTCTACCGTGGGCAAGAACCACGAGTGGAACTGGGCCTTCGTCTGCTTCACCCT
GGCCTTCTGCCTCATGTGGCGAGCCCTGGGTGTTTTTGTCCTGACTCAGGTCATTAATAGGTTCCGGACCATTCCCCTGACCTTTAAGGA
CCAGTTCATCATTGCCTATGGAGGACTTCGAGGTGCCATCTGTTTTGCGTTAGTGTTTCTCCTTCCTGCTGCTGTGTTTCCTCGGAAAAA
ATTGTTTATTACGGCTGCCATTGTTGTCATATTCTTTACTGTCTTCATTCTGGGAATAACTATTCGACCACTGGTGGAGTTTCTTGATGT
CAAGAGGTCCAATAAGAAACAACAAGCTGTCAGTGAAGAAATCTATTGTCGGTTGTTTGATCATGTGAAGACTGGAATTGAAGATGTTTG
TGGACATTGGGGTCACAACTTTTGGAGAGACAAGTTTAAGAAGTTTGATGATAAATATCTGCGGAAGCTTTTGATTCGGGAAAACCAACC
AAAGTCAAGTATTGTATCTTTATATAAAAAGCTTGAAATAAAACATGCCATTGAGATGGCAGAGACTGGGATGATAAGTACTGTCCCTAC
ATTTGCATCTCTAAATGATTGTCGTGAAGAAAAAATAAGGAAGGTCACGTCCAGTGAAACTGATGAAATTCGAGAACTCTTATCAAGAAA
TCTCTATCAAATCCGTCAGCGAACTTTATCCTACAACAGACACAGTCTGACAGCCGACACAAGTGAGAGACAAGCCAAGGAGATTCTGAT
TCGCCGGCGACACAGTTTGCGAGAAAGCATTAGGAAGGACAGCAGCTTGAATCGAGAACACAGGGCTTCCACTTCAACCTCCCGATATTT
ATCCTTACCTAAAAATACGAAGCTTCCAGAAAAGCTACAAAAGAGGAGGACTATTTCTATTGCAGATGGCAATAGCAGCGACTCAGACGC
AGATGCCGGGACCACCGTGCTCAATTTGCAGCCCAGAGCCAGGCGCTTCTTGCCAGAACAGTTCTCCAAGAAATCCCCCCAGTCCTATAA
AATGGAATGGAAGAATGAGGTAGATGTTGATTCTGGCCGAGATATGCCCAGCACCCCCCCAACACCCCACAGCAGAGAAAAGGGCACCCA
GACGTCAGGCTTACTACAGCAGCCCCTTCTCTCTAAAGACCAGTCTGGCTCAGAGAGGGAAGACAGTTTGACTGAAGGCATCCCGCCCAA
GCCGCCACCACGGCTGGTCTGGAGGGCATCGGAACCTGGAAGCCGGAAAGCCCGATTTGGGAGTGAGAAGCCTTAAGAGAAGCAGCGAAA
GCAGATCTGAGTGTCTGACCCAGGACAGCTGTGGTTTGTCACTCTGAAACCTGATGCAACAGTGGAATCCATGTAAAACTCTCTGTGCAT
CTAAATACTTCTGGAGGGCGACAGATTCATGCCACGGATAAATGAGGCAAATCCGAAGAAAAGGAAAATCGAATAAAAAATAGTCCCACA
AAATACCTTTTGTGACTAATGGGTAGCAATCGTATTATTTGCTGGCCTGAAGAGAAAAAATGGTAATGTGTGCCTTTATTGAACTTGAAT
GACAGAACTTGAAATTTTTAACACATCCTTCTTGGTGAAGATTTTAATATATTACTTATATGCTTCAAATTTTATTTATGAAAAAATATG
TATATCTGTAATCAGTTGTTAAGTGAATGGCACTAAAAGTATCGAGAACAGCTTTCTTTCCCAGGGGTGAAGGATGGCGCTCGGGGGTGA
CTCCTAAGCTCAGCGTGGAAGCTTTTCCCTGTCCTGACCCGATGGAGCAGCCGGTAAGTGAAGAGCACAGCTGGAAGCAGAGACACCTTA
TGACTCAAACTGGGCAAACAATCGGAACGTCATGCAGAAGGAATGGCCTGACTCCTGCAGTGCAGATTGGAGGCCCCAGAACTCCTATGA
ACTACTGAGAGTCTACTGGTTTTTAACTTGTTCCTCTGTCTACTGTGTGTTTGGGGGTGACATCTAAATTCCATTTCTTCTTCTTGTTTA
AATGGTGCAGAGAGAAAGGTTGCCCAGACATCCACCAGCTTACTGTGTTGACAGATTTGGGAGCAGCTTTTGATGAAGTTCCACCCATGA
GGGTCCATGTGGCAAGTAGGGCCACAGGGCAGCACCTGGTTACAACTTGCTGGTGGGTTTTATGTTGTGCAATACTAGGAGGAGGAGGCA
GGTGATCTATGCTGATCTATGATCACCTGCTTCAGTAGAATTTTTCTGTAGAGTGTTGTTTGAATTTTGAGCCTCCAGGTTAGAGGCTCC
AAGCAGACAAAGAAGAAAGTTTGTAGACACAATATTCTAACATTGCACAAGTTGATGAGATATCAAGTTTTGAATATTATTCAGGAAGCA
CTTTGGAGAATGTGGGAGTCCTACTGTTTTGCACTAGTCTGTAATTTGTTACCTCTCCCCATTCGATAATATAGTAACTCAGAATTTTCA
TATAAAATTGAATTCTACTCATTAGAGTACTTTTTAAAAGTACAGCAGAAAGAAAAGAAGTGGAACATAAGCATTCAAGATTAATATTTG
ATTCTCTATCTCTTAACTGTAGATTTTATTGGCCTGTTTTTTTTTTCTAAATAATTCTTTAAAACTTGACTGGAACATGCCTCTGCATTT
CTGAGTGTAGAAATTAAATGAAGCCACTCACAGTCCTTTGATTTCCCACTGAAGATACCCCAAAGGATGCAAGTGCCTACAGTATTATCA
GGAGGAGAACATGAAAATATTAAGACAAAAATCCTCAGCAGTTGTTCTCCACCCCTTCTCCACCTCCACCAGCAAGGAGAAGTCAATCTA
CACTTTTTTCTCATGTTCTAAAGTCTTAGAATACTGCTGGATTGTTGAGCATGAGACAGAGCAAAGGTTAGATACACAAGGTACAAGTTC
ATAGGAGCACAATTCCTTGATTCAGGGAAAGTAGCACAGAATGCAATTTGAAAACTACAGGCTTAGGACTCTGTGCCAAAAATCTCTATT
TTAAATGAAAATATTTATATAAAAATACATTTATTCTGCTTAACACAAATTAAAACTGACATAAAATTTTATGATAATAACATGATTCAA
GAAATGTGATGTAGATTTTTGAGAATGCCAAAAATCAGGTTTCAGAAAAGCTACAGTATGAAATCTGAAAAGCAACAGAAATTGAAAGTG
ACCTTAAAGAATAAATTTCCTAATTTTTCCCAGTTTCCTATGTTTATAACTATTATAAAGAGTTTAACTTTCTGGAACTGAAGGAGAAAA
CATGAAAATGTTTATATTGCTTCTTGTTAAGCAGGTAGACCAAATTCCGCTTTCAGTAATTCATCCATACAGAATTTGGATGACTATGTA
TAAAGGAAAACTTAAATCTTAATTATTATCAGTTTAAATTTTTTTTGTTTGTTGAATGACAAAGGCAATAAAAATAAATTTGACTTTAGC
TTTTTTTCTATACTTTCCTCTTTTTGTAATTCTTAAATTCTAGTCACTAGTCATTATGAGAGTATTGACTAAATATTTTCACAATCTAAA
TATTGTCACAATCTAAATTTCTGTAGTAGAGAGAGCCGTAGCCCTTTGTAAAGGCTTTCGTTCGTCCAAACAACACTTGATCCAACCAAA
GTTCCAATGTGACTGTGGATCTTTGATAGGTCTTTGGTGTTGGTTGTAACAAAATTTGATTTGAACTACCTATAAATGAAAAGTCGGGGT
TTATTACTTTATATGTAATGCTGAGAGGAGACTGTTGGGAACAGTTATGTCAATGAGCAAACTAGAAATTGGCTTCAAAGTCTAATACTT
TTAAAAGCATGTGTTTTGTGTATATGCTCACAAAATGTCTGTGAAGAGATTTCTTTCAGCTTTTGCTCAGCTTTATGGTGGGGTGTACTG
TTTTATCTGGGCGGTGAGGGTATTGATTTACATAAAAACTGTAGACAAACACAGTACGAGTCTCAGCACGTTTTGCATTTATTGTACTGC
CCAAATTGTTTTTATGTTAAAAGTCACGTTTCATAATCTGCAATATTTTTGTCAAAGTGCACACTGTACTTTCTTCTTAAAAACGTGATT

>91826_91826_3_TMEM182-SLC9A2_TMEM182_chr2_103380886_ENST00000412401_SLC9A2_chr2_103274023_ENST00000233969_length(amino acids)=828AA_BP=113
MKMRLNIAIFFGALFGALGVLLFLVAFGSDYWLLATEVGRCSGEKNIENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSKNCTH
AYLSPYPFMRGEHNSTSYDSAVSFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFE
NIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLY
NLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMN
KYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAY
GGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHN
FWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQ
RTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTV
LNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLV

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Fusion Gene PPI Analysis for TMEM182-SLC9A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TMEM182-SLC9A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TMEM182-SLC9A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource