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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:TMEM230-LMTK2 (FusionGDB2 ID:91934)

Fusion Gene Summary for TMEM230-LMTK2

Fusion gene summary

Fusion gene information	Fusion gene name: TMEM230-LMTK2
	Fusion gene ID: 91934
		Hgene	Tgene
	Gene symbol	TMEM230	LMTK2
	Gene ID	29058	22853
	Gene name	transmembrane protein 230	lemur tyrosine kinase 2
	Synonyms	C20orf30\|HSPC274\|dJ1116H23.2.1	AATYK2\|BREK\|KPI-2\|KPI2\|LMR2\|PPP1R100\|cprk\|hBREK
	Cytomap	20p13-p12.3	7q21.3
	Type of gene	protein-coding	protein-coding
	Description	transmembrane protein 230UPF0414 transmembrane protein C20orf30	serine/threonine-protein kinase LMTK2CDK5/p35-regulated kinaseapoptosis-associated tyrosine kinase 2brain-enriched kinasecyclin-dependent kinase 5/p35-regulated kinasekinase/phosphatase/inhibitor 2protein phosphatase 1, regulatory subunit 100serine
	Modification date	20200320	20200313
	UniProtAcc	.	Q8IWU2
	Ensembl transtripts involved in fusion gene	ENST00000202834, ENST00000342308, ENST00000379277, ENST00000379279, ENST00000379283, ENST00000379286, ENST00000492419,	ENST00000493372, ENST00000297293,
Fusion gene scores	* DoF score	7 X 6 X 3=126	6 X 6 X 3=108
	# samples	7	6
	** MAII score	log2(7/126*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TMEM230 [Title/Abstract] AND LMTK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	TMEM230(5086833)-LMTK2(97820039), # samples:1
Anticipated loss of major functional domain due to fusion event.	TMEM230-LMTK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. TMEM230-LMTK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TMEM230-LMTK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LMTK2	GO:0006468	protein phosphorylation	12393858
Tgene	LMTK2	GO:0018105	peptidyl-serine phosphorylation	16887929
Tgene	LMTK2	GO:0018107	peptidyl-threonine phosphorylation	16887929
Tgene	LMTK2	GO:0046777	protein autophosphorylation	12393858

Fusion gene breakpoints across TMEM230 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LMTK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-62-A46U	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+

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Fusion Gene ORF analysis for TMEM230-LMTK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000202834	ENST00000493372	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
5CDS-intron	ENST00000342308	ENST00000493372	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
5CDS-intron	ENST00000379277	ENST00000493372	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
5CDS-intron	ENST00000379279	ENST00000493372	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
5CDS-intron	ENST00000379283	ENST00000493372	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
5CDS-intron	ENST00000379286	ENST00000493372	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
5UTR-3CDS	ENST00000492419	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
5UTR-intron	ENST00000492419	ENST00000493372	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000202834	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000342308	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000379277	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000379279	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
Frame-shift	ENST00000379286	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+
In-frame	ENST00000379283	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000379283

TMEM230

chr20

5086833

ENST00000297293

LMTK2

chr7

97820039

8223

568

572

4081

1169

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000379283	ENST00000297293	TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+	0.000398448	0.99960154

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Fusion Genomic Features for TMEM230-LMTK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+	1.44E-10	1
TMEM230	chr20	5086833	-	LMTK2	chr7	97820039	+	1.44E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for TMEM230-LMTK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:5086833/chr7:97820039)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	LMTK2 Q8IWU2
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Phosphorylates PPP1C, phosphorylase b and CFTR.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000202834

46_66

121.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000342308

46_66

137

184.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000342308

79_99

137

184.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379277

46_66

121.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379279

46_66

121.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379283

46_66

121.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379286

46_66

121.0

Transmembrane

Helical

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

1451_1454

332

1504.0

Compositional bias

Note=Poly-Pro

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000202834

79_99

121.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379277

79_99

121.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379279

79_99

121.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379283

79_99

121.0

Transmembrane

Helical

Hgene

TMEM230

chr20:5086833

chr7:97820039

ENST00000379286

79_99

121.0

Transmembrane

Helical

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

137_407

332

1504.0

Domain

Protein kinase

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

143_151

332

1504.0

Nucleotide binding

ATP

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

1_10

332

1504.0

Topological domain

Cytoplasmic

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

32_42

332

1504.0

Topological domain

Lumenal

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

64_1503

332

1504.0

Topological domain

Cytoplasmic

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

11_31

332

1504.0

Transmembrane

Helical

Tgene

LMTK2

chr20:5086833

chr7:97820039

ENST00000297293

43_63

332

1504.0

Transmembrane

Helical

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Fusion Gene Sequence for TMEM230-LMTK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>91934_91934_1_TMEM230-LMTK2_TMEM230_chr20_5086833_ENST00000379283_LMTK2_chr7_97820039_ENST00000297293_length(transcript)=8223nt_BP=568nt
TGGCACTTAAGCGGGCCATGCCATGCAACCTTGGGCGCTGCCAACCGTGGGCGAGCTCTGGGTGTGCGGGCGGCCTGGCGCGGCGCTCCG
GTAAGGCGTGTGTGCGGCAGGGCGGGGACAGAACCGTCCTCTCGGGCTCTGGGCGTGTCCGAGACCGCGCTCCCCGCCGAAATCAAGCTC
CGAGTCATCCGTGTGGGGCATTCGTCCCCCCTGGCACAGTTGGCCTCTTTCCAGAAGCCCGTTTTGTTTGTTTTACGTCTAAATTCGCGT
CGGTTCTTATTTCTCTCCCTGGCAAGGTCTGAAGACGGGTAGGAGAATAACGTATGTAGAGCTGTGTCAGCGTGTTATGATGCCGTCCCG
TACCAACCTGGCTACTGGAATCCCCAGTAGTAAAGTGAAATATTCAAGGCTCTCCAGCACAGACGATGGCTACATTGACCTTCAGTTTAA
GAAAACCCCTCCTAAGATCCCTTATAAGGCCATCGCACTTGCCACTGTGCTGTTTTTGATTGGCGCCTTTCTCATTATTATAGGCTCCCT
CCTGCTGTCAGGCTACATCAGCAAAGGGGTCTCTGGGTGTGACACTTTGGGAGCTTTTTGACAATGCCGCACAGCCGTATTCAAACCTTT
CCAACTTAGATGTCCTCAACCAAGTCATTAGAGAGAGAGACACAAAACTCCCGAAGCCCCAGCTGGAGCAGCCCTACTCTGATAGATGGT
ATGAAGTCTTACAGTTCTGTTGGCTGTCACCAGAAAAGAGACCCGCGGCTGAAGATGTGCACAGGCTGCTGACTTACCTGCGGCTGCAGA
GCCAGCGGGACTCAGAGGTCGACTTTGAACAGCAGTGGAACGCTCTGAAGCCGAACACAAACAGCAGAGACTCCTCCAACAATGCTGCAT
TCCCAATTCTCGACCACTTTGCCAGGGACCGGCTGGGTCGTGAAATGGAGGAAGTCCTCACCGTGACCGAAACCAGCCAGGGCCTGAGCT
TCGAGTATGTCTGGGAGGCCGCTAAGCACGACCACTTTGACGAGCGCAGCCGGGGCCACCTGGACGAAGGCTTGTCCTACACGAGCATCT
TCTATCCGGTTGAAGTTTTTGAGAGTTCGCTTTCAGATCCTGGGCCCGGAAAGCAAGATGACAGCGGCCAGGATGTCCCCCTGAGGGTCC
CTGGAGTGGTTCCTGTTTTTGATGCCCACAACCTTTCTGTTGGAAGCGACTATTATATCCAGTTAGAAGAAAAAAGTGGTAGTAACTTGG
AGCTTGATTACCCACCAGCGCTGCTCACAACCGACATGGATAATCCAGAAAGGACTGGCCCTGAACTGTCCCAGCTCACGGCGCTCAGGA
GCGTTGAACTTGAGGAGTCCAGTACAGATGAGGACTTCTTCCAAAGCAGTACAGACCCCAAAGACTCTAGCTTACCAGGGGACTTACACG
TGACCAGTGGCCCCGAGAGCCCTTTCAACAATATATTTAATGATGTGGACAAATCGGAAGATTTGCCCAGTCACCAAAAAATATTCGACT
TAATGGAATTAAACGGAGTTCAAGCCGACTTTAAACCTGCCACTTTAAGTTCCAGTTTGGATAACCCCAAAGAGTCAGTCATAACAGGCC
ACTTTGAGAAAGAAAAGCCCCGTAAGATTTTTGACAGTGAGCCTCTCTGCCTATCAGATAATCTTATGCACCAAGATAATTTTGATCCAT
TGAATGTTCAAGAATTGTCAGAAAACTTTTTATTTCTTCAAGAGAAAAACTTACTAAAAGGCTCATTGTCCAGCAAAGAACACATAAATG
ATCTTCAGACAGAACTTAAGAATGCTGGTTTTACTGAAGCTATGTTAGAAACGTCATGTAGAAACTCTTTAGATACTGAGCTTCAGTTTG
CTGAAAATAAGCCAGGCTTGTCTTTGTTGCAGGAAAACGTAAGCACAAAGGGTGACGATACAGATGTCATGCTCACAGGTGACACTTTGA
GCACCTCATTGCAGTCTTCCCCGGAAGTGCAGGTACCTCCTACCTCCTTCGAAACAGAAGAAACGCCCCGTCGGGTACCCCCAGACTCAC
TCCCAACACAGGGAGAAACCCAGCCCACGTGTTTAGATGTTATTGTCCCGGAGGACTGTCTCCACCAGGACATCAGTCCAGACGCTGTGA
CTGTCCCGGTTGAAATTCTCTCAACTGATGCCAGAACCCACAGCCTGGATAACAGGTCCCAGGACTCTCCTGGCGAGAGTGAGGAGACCC
TGCGACTCACCGAAAGTGACTCTGTTCTTGCTGATGACATCCTTGCCAGCAGGGTGAGTGTAGGGAGTAGTCTCCCGGAACTGGGACAGG
AATTGCACAATAAACCATTTTCGGAAGACCATCACAGTCATCGCCGGCTAGAGAAAAACTTAGAGGCTGTGGAGACTTTAAATCAGCTCA
ATTCTAAAGACGCAGCAAAAGAAGCAGGCTTGGTGTCTGCCCTCTCCTCGGACTCAACCAGTCAGGACAGCCTCCTGGAGGACAGCTTGT
CAGCACCCTTCCCAGCCTCTGAGCCGTCCCTGGAAACCCCGGACTCTCTGGAGTCAGTGGATGTCCACGAAGCGCTACTGGACTCTTTAG
GATCTCACACTCCCCAGAAACTAGTGCCCCCCGATAAGCCGGCAGACAGTGGCTACGAAACAGAGAACTTGGAGTCTCCCGAGTGGACCT
TGCATCCCGCTCCCGAGGGCACCGCAGACTCAGAACCAGCCACCACGGGCGATGGCGGCCACAGCGGTCTGCCTCCCAACCCGGTCATTG
TCATCTCAGATGCCGGCGATGGTCACAGAGGCACAGAAGTGACCCCTGAGACGTTCACAGCTGGCTCCCAGGGTTCATACCGAGACTCTG
CGTACTTCTCAGACAATGACTCTGAGCCCGAGAAAAGGTCTGAGGAGGTCCCGGGAACCTCCCCATCCGCCTTGGTGTTGGTACAGGAGC
AGCCCCTACCCGAGCCAGTCCTCCCCGAGCAAAGTCCTGCTGCCCAGGATAGCTGCCTGGAAGCCAGAAAGAGCCAGCCAGATGAAAGTT
GTCTGTCTGCTTTGCACAACTCCAGTGACCTGGAATTAAGAGCCACGCCGGAGCCAGCACAGACTGGTGTTCCCCAGCAGGTGCATCCCA
CGGAAGACGAGGCCAGCAGTCCCTGGAGTGTGCTGAATGCAGAACTTAGCAGCGGCGATGACTTCGAGACACAGGACGATCGCCCCTGCA
CCCTCGCTTCCACGGGGACCAACACGAACGAACTCCTTGCCTACACCAATTCTGCGCTGGACAAGTCCCTGTCCAGCCACTCCGAGGGCC
CGAAGTTGAAGGAGCCGGACATCGAAGGGAAGTACCTGGGGAAACTCGGGGTGTCAGGGATGCTCGACCTCTCAGAGGACGGGATGGATG
CAGACGAGGAGGACGAAAACAGCGACGACTCGGACGAGGACCTGCGGGCCTTCAACCTGCATAGCCTCAGCTCCGAGTCGGAGGACGAGA
CCGAGCACCCCGTGCCCATCATCCTCAGCAACGAGGACGGAAGGCACCTGCGGAGTCTGTTGAAGCCCACAGCGGCCAATGCCCCCGACC
CACTGCCCGAGGACTGGAAGAAGGAAAAGAAGGCAGTCACGTTTTTCGATGATGTCACAGTCTACCTGTTTGACCAGGAGACCCCAACCA
AAGAGCTGGGGCCCTGTGGAGGAGAGGCGTGCGGCCCGGACCTGAGCGGCCCAGCCCCAGCCTCAGGCTCTCCCTACCTGAGCAGGTGCA
TCAACTCCGAAAGCTCCACCGACGAAGAAGGTGGTGGCTTTGAGTGGGATGATGACTTCTCCCCAGATCCTTTTATGTCAAAGACAACAA
GTAACCTGCTCAGCTCCAAGCCTTCTCTCCAAACATCCAAGTACTTTTCTCCGCCGCCACCGGCCCGGAGCACGGAGCAGAGCTGGCCGC
ACTCGGCGCCTTACTCCCGGTTCTCCATCTCTCCCGCCAACATTGCCAGCTTTTCCCTCACACACCTGACCGACTCGGACATCGAGCAGG
GCGGAAGCAGCGAAGACGGAGAAAAGGACTAGGTGGCTGCCAACGCGCACGCTCGGGTCCGAGGCTGCTCCCCTGGAGCGGCGCCCCTGC
GCCCTCAGCCCGAGCAGCGACATCCACTCGCCATTTGCTGACATGAGATTGGGAGGAAGAATCCAGAGGTGAAGAGGGAGACGGCTCTTA
GCTGCGTTCAAGGCGGGGCCCTCGGGAGCCCAGGTGCAGAGCGAGGCCGTGTCCAGGAGCCGGCGTCCCTCAGTGCCCCGTGCACCCGCG
GCCGCGGCCTCCCAGGCAGTGCTCATGCGCTGGCCGTCGGGGGAGGCAGGGGCACAGCCTCCATGTGCGCGCGCGTGTGGAGCTGTGTGC
ACCGCATGTGTGCTTTCCACAGGGGCGTCTCTGCGTCCACGCCTGCACATCCCGGCGCACGTGTGGGCACCACAGAGGACACGTGAGGGG
AATGGTCACCAGTGAGCCATATTTATTATTTCTAGAGAAATCACGAACTGCTTTCTGTAATTGCACTGTGGATAAATGTTCCGAGAGTCT
CCATTGTTGTACAGGATCTTCAGTTATTCGAGGGGAATGAGGCAGGTCAAGCCGATGCTAGCCACTAGTTTGATTTTTTTTCTGTTTTAT
AGTTTGCGCTGCATGGTACTTGTGAAGCTTAAATATTTTGAGTGTTCTACTGTGTCTAGGATTGTTGGGATTGTACATATGGTACTCTTT
CATAAATGATAAATGATTCTGAATGTTAGTGTTTTATGTTCATATAGGAAATATTTTCATTGAGTCCAAAATACCACTGTTTTGTTGATG
GACTTGAATGCATTTTTGTCTCTTCTTGATGAAGCGGCTTTGCCGCAGCAAATGAGGCTTCTCTCTGAGGAGCTGAGAGGTCTTGCAGCC
TCTCCTTGTCATTCTCCCACCCCACATCCCATTTTTTAAAGCCCTTTTGGTAAAAACCAACAGGTTGTGGCCGCAGACCTCAGATGGACC
CGGCCCATCCCTGGGGACGTGCTGGCGTGGCAGGTCCAGAGAGCTGCACCCTGCACGGGGCACCGCACCGCTTCCCTCCGCGCAGCTCTT
CTGCCTGGTTTTCGGAGGCCAGGCTGCTGGGAAGCTTCCGTGTTCCTGTCAGTCCTTCCTTCAAGAAGCCGGGGAACTCAGGCAGACTCA
TCTCCGCAGAGCATACCAGCCGTGGGGGACCGTTCGACTTGATGATGTGTGCACACTTCAGGTGGTGGGGACTTGAGCTTTAAAAAAACC
TCCACAGCCGAATCTTCTCCTCCGAGCCACTCCACGTCACGTCCAGCTGGGCCTGGCCAGTCTGTGGTTATCCATGTGGGATGAGATAAC
ACCACATCCTGCAGCTGTGAAGGGGGATGGACAAGGGACGACGGCCGACGGCAGAGCATCAGCAGCCGACACATAGTTCGGGTCGGGGCC
TTGGGTGGTCCTGCATGGCCCGGGACTCATCTCACGGACCCTCCGTTCTGCATTAAGCCCCAGGTTCTCTTCTGGCTTTGAAAGGGCCCG
AGTGCTCCCAGTGTAGCTTCGTCACATCGTCACGAGCCCCTGTGGTCATGGGCGACCTCACACCTCCCTCCCTGAGTTCTGCTCTGACAT
AAGGAAGTCCTCGGTGGCTGGTGCAGCGCGGCTGTGCTGTGCTGGGGAGGCAGCCGTTCCTTCGGGGGTCCTTGGGCCTGCAGTCCCCTC
ATACTCACCCTTCACCCAACATATTTTCCGGTGCTGATATGTTTCCAGACTCCAGCGCAACCTGGGGTGCTCTCCAGACCCGTGCAGGGG
CCGCCTGGGGTACACGGAAGGAAGTTGAGTCCTAGTGCAAAATGCAGGCGGACGTTGCCAGAGAGTGCGCAGCAAATGACCTTCATTGCC
AGTTCCACCCTACTCCTCTCATTTTTTATACTAAGCAATAACTTTCCAAAGCAAGAAGTTCAGGATGGAGAGAGTCCCCTCCTGTGTAGG
CATGGGGTGGATGCGGTGCCCACCTGGGCTATGTGGGGAGCACCACTGTCTCGGGATGCGCGAATTTTTTTTTTTTTTTTAATTAACAGG
GCATTAGAAGATGATTTTGCCAAAATTGTCATGACTCTGAATTCTTGCTGTGGGGACTTCCTGAGTTTTCTCAGTTTTTACATCTAAGAT
TAGTCTTGGCTGAAGAGAAATGAGACGTGATTATACTACTTTTTCAATTGCAGGTTTAAGGAGTTCAGATTTAATGACCAAAGTCATACA
GATCATGGAATCTGTCGTCGTCTTATACAGTGTCAGCCTCGAGTACATTTATTAACCTTTTGGGGCTGTCAGTTTTCCACTAGGATTAAG
ATTTTGGCCGGGCGCGGTGGCTCACGCCTGCAATCCCAACACATTGGGGGGTCGAGGCGGACGGATCACTTTGAGCCCAGGAGTTCAAGA
CCAGCCTGGGCAACATGGCGAAACCTCGTCTCTACTAAAAATACAAAATATATATATATATATATATACTAGCTGGGGCACATAGTGGTG
TGCACCTGTAGTCCCAGCTGCTTGGGAGGCTGAGGTGGGAGGATGGCTAGAGCCCAGGAGATGGGTGTTGCAGTGAGCTGAGACCATGCC
ACTGTACTCTAGCCTGGGTAACAGCCAGACCCTGTCTCAAAAAAAAAAACAATTTTTTTCATAACATAATTCCCATTTTTATTTATTTTG
AGTCACTCATAATTAATTGCCAAAAAAGCATTTTATACATTGAGTTGGGGGGTAGTGGATCTTAGTGTGGTGTTGCATGGAGGGGCGAGA
TTTTATATTTATAATCAACACGTGGGTTAACATGTTTTTTTGAAATCCAAGCAATACACAGGAAATTTAAGTAGAATAAAAATTGCAGCC
CATTTTTGAAATGTCAGCATGTGCTGTGTTCAGTTCAGGTTTTTGTTGTTTGTTTTGTTATTTTTTAACTAATAAGTTGGTTATCAGTGG
TGGGTTTTCAAAATGTACTTGTTCTAATAAGTTGTACAATGAACTAAATCAGTGGCATTCTCTAGATAATGTGGGGGAAGGTTAGAATAT
TTTCTGGCCTTCTATGGGGTAGCAACCCAGAATCAATCTGAATTAGTCCTGTTTTGGTGGAGTTTGTACATTTTAAATCCTATAACAAAA
ATAATCTAGTTTTCATTTCCTTACTAGCTAGATGCGAATTTGTCTTTTTGAATGACCCTGTCAATAAGCCAGAAAGGGCAACCCAGAAAA
AGTGCTCCCCACATCCTTCTGAGACTTGGCCTGTGTGTGTGGACGAGAAGCCATTCACCGTAAGGGTGCAGAAAGCTCGACCAAGCCGAA
TTGCAAACAACGTTCGTTCTATTTTTAAATGTACAGGTTCGATCGTTTCTATAGAAATGGGTTTATCTAAGAAAAGTCTTGGTTTGTCTT
GCTGCTGTAAAAGGCCTTTCCAAACCCCTCCTTTTATTCCTGTTTCCCGAAATAAGGTATTTGTAGAGTTAAGGACCTACTGCATGCCTG
TCCCCAGGGCCCCGGTGGAAGGAAGGCAGCGCCTGCTCTTCCTTAACTCAGCCCATCATCTGAAAATTCAGAAGTGAACCAAGGGTTAGA
CGCCAGAGGTTGGGCTTCTGTTAGAGTGGCTTCAAAACATGAGCCTTATGGGAAGTAGCCTTAAAAAAAGAATGGGTATACGCAGTGACT
TCCGATGGAAATCTCCAAAACAATATTCCTAAGTAGCAATGGGGTTGGCTCAAGTCTTTATTAACAAAGAACATTCTCTTTCATCTATAA
AGAAATTCTTAAAGATGCATTGACAGTGTTGAATTACCAACAGCCTGTGAAGATCAGTTTGACCGGTGTGGACACGTGCTGGTTAAGCAC
TCAGGCCTACGTGGGCCGAGCGGGATCTTGATCATGGGGCTGGTGTATGGATCCACCGTCGGATTCCGTCTGCAGAGGAGGACGTAGGGG
GCCGTCACACCCACCAGGCCTCCCTGCTGTGCTTTAACACAGGCAGAAGAGGTTCATGGCAATATAATAGTCAATGAACTTTCAGTTTAA
ATTGTGTACATTTTTAAATTGTAAGATTTTTACTGTATATTGATGCATAGTGTGATTCAATAAATTGCTTGTAATTTAAAAACTATTTAA

>91934_91934_1_TMEM230-LMTK2_TMEM230_chr20_5086833_ENST00000379283_LMTK2_chr7_97820039_ENST00000297293_length(amino acids)=1169AA_BP=1
MGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQ
QWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSL
SDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEESSTDE
DFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIF
DSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQ
ENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDA
RTHSLDNRSQDSPGESEETLRLTESDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAKEAGL
VSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTLHPAPEGTADS
EPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQ
SPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNTNE
LLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSN
EDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEG

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Fusion Gene PPI Analysis for TMEM230-LMTK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for TMEM230-LMTK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for TMEM230-LMTK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source